MCID: RTN004
MIFTS: 32

Retinal Microaneurysm

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Retinal Microaneurysm

MalaCards integrated aliases for Retinal Microaneurysm:

Name: Retinal Microaneurysm 12 15 70
Microaneurysm 44

Classifications:



External Ids:

Disease Ontology 12 DOID:11295
ICD9CM 34 362.14
MeSH 44 D000071071
SNOMED-CT 67 34037000
UMLS 70 C0154834

Summaries for Retinal Microaneurysm

MalaCards based summary : Retinal Microaneurysm, also known as microaneurysm, is related to microvascular complications of diabetes 5 and microvascular complications of diabetes 1. An important gene associated with Retinal Microaneurysm is MIR20A (MicroRNA 20a), and among its related pathways/superpathways are Differentiation Pathway and Signaling events mediated by TCPTP. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include retina, endothelial and eye, and related phenotype is renal/urinary system.

Wikipedia : 73 Charcot-Bouchard aneurysms are aneurysms of the brain vasculature which occur in small blood vessels... more...

Related Diseases for Retinal Microaneurysm

Diseases related to Retinal Microaneurysm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 30.3 VEGFA MIR20A INS AKR1B1
2 microvascular complications of diabetes 1 29.9 VEGFA INS AKR1B1
3 macular retinal edema 29.8 VEGFA INS AKR1B1
4 diabetic macular edema 29.7 VEGFA REN AKR1B1
5 background diabetic retinopathy 29.6 VEGFA INS GADD45G AKR1B1
6 type 1 diabetes mellitus 29.1 VEGFA REN INS AKR1B1
7 severe nonproliferative diabetic retinopathy 28.8 VEGFA REN LINC00343 INS GADD45G AKR1B1
8 retinal vascular disease 28.7 VEGFA REN MIR20A INS AKR1B1
9 diabetes mellitus 28.7 VEGFA REN MIR20A INS AKR1B1
10 yemenite deaf-blind hypopigmentation syndrome 10.2
11 retroperitoneal hemangiopericytoma 10.2 VEGFA INS
12 rubeosis iridis 10.2 VEGFA INS
13 hypoglycemic coma 10.2 VEGFA INS
14 decubitus ulcer 10.1 VEGFA INS
15 chronic ulcer of skin 10.1 VEGFA INS
16 transient refractive change 10.1 INS AKR1B1
17 microvascular complications of diabetes 2 10.1
18 vein disease 10.1 VEGFA INS
19 diabetic cataract 10.1 VEGFA AKR1B1
20 nephrosclerosis 10.0 VEGFA INS
21 sensory system disease 10.0 VEGFA MIR20A INS
22 retinal detachment 10.0
23 retinal vein occlusion 10.0
24 retinal disease 10.0
25 aging 10.0
26 eye disease 10.0
27 persistent fetal circulation syndrome 10.0 VEGFA INS
28 hypertensive encephalopathy 9.9 VEGFA REN
29 hypertensive retinopathy 9.9 VEGFA REN
30 generalized atherosclerosis 9.9 REN INS
31 potter's syndrome 9.9 REN INS
32 benign essential hypertension 9.9 REN INS
33 kidney hypertrophy 9.9 REN INS
34 diabetic polyneuropathy 9.9 VEGFA INS AKR1B1
35 polyneuropathy 9.9 VEGFA INS AKR1B1
36 lens disease 9.9 VEGFA INS AKR1B1
37 steroid inherited metabolic disorder 9.9 REN INS
38 adrenal cortical hypofunction 9.9 REN INS
39 pericardium disease 9.9 VEGFA REN
40 pyelitis 9.9 REN INS
41 carpal tunnel syndrome 9.9 VEGFA INS
42 intermediate coronary syndrome 9.9 REN INS
43 adult syndrome 9.8 REN INS
44 adrenal cortex disease 9.8 REN INS
45 pericardial effusion 9.8 VEGFA REN
46 type 2 diabetes mellitus 9.8
47 fibromuscular dysplasia 9.8
48 stroke, ischemic 9.8
49 allergic disease 9.8
50 retinal ischemia 9.8

Comorbidity relations with Retinal Microaneurysm via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Microaneurysm:



Diseases related to Retinal Microaneurysm

Symptoms & Phenotypes for Retinal Microaneurysm

MGI Mouse Phenotypes related to Retinal Microaneurysm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.02 AKR1B1 GADD45G INS REN VEGFA

Drugs & Therapeutics for Retinal Microaneurysm

Drugs for Retinal Microaneurysm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4
3 Anesthetics Phase 4
4
Triamcinolone Approved, Vet_approved Phase 1 124-94-7 31307
5 triamcinolone acetonide Phase 1
6 Triamcinolone diacetate Phase 1
7 Triamcinolone hexacetonide Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Single-center, Six-month Study of Intravitreal Ranibizumab for Macular Edema With Nonproliferative Diabetic Retinopathy: Effects on Microaneurysm Turnover and Non-perfused Retinal Area Completed NCT02834663 Phase 4 Lucentis
2 Three-year Result of Triple Therapy of Vitrectomy, Intravitreal Triamcinolone and Macular Laser Photocoagulation for Intractable Diabetic Macular Edema Completed NCT01202461 Phase 1
3 Comparison Between Treatment With Yellow Micropulse Laser and Green Conventional Laser in Diabetic Macular Edema Unknown status NCT01928654
4 Evaluation of Heidelberg Engineering SPECTRALIS With OCT Angiography Module Completed NCT03279939
5 Treatment of Macular Edema Caused by Leber's Miliary Aneurysms Using Intravitreal Aflibercept and Peripheral Laser Photocoagulation Recruiting NCT03908723
6 Evaluation of Additional Heidelberg Engineering SPECTRALIS With OCT Angiography Module (OCTA Module) Scan Types Recruiting NCT04604002
7 Evaluation of the Repeatability and Reproducibility of OCTA Image Quality With the Heidelberg Engineering SPECTRALIS With OCT Angiography Module Terminated NCT03530449

Search NIH Clinical Center for Retinal Microaneurysm

Cochrane evidence based reviews: microaneurysm

Genetic Tests for Retinal Microaneurysm

Anatomical Context for Retinal Microaneurysm

MalaCards organs/tissues related to Retinal Microaneurysm:

40
Retina, Endothelial, Eye, Brain, Kidney, Liver, Bone

Publications for Retinal Microaneurysm

Articles related to Retinal Microaneurysm:

(show top 50) (show all 382)
# Title Authors PMID Year
1
Automated Microaneurysm Counts on Ultrawide Field Color and Fluorescein Angiography Images. 61
33779483 2021
2
Artificial intelligence velocimetry and microaneurysm-on-a-chip for three-dimensional analysis of blood flow in physiology and disease. 61
33762307 2021
3
Different retinopathy phenotypes in type 2 diabetes predict retinopathy progression. 61
33025221 2021
4
Clinical profile and incidence of microvascular complications of childhood and adolescent onset type 1 and type 2 diabetes seen at a tertiary diabetes center in India. 61
32333449 2021
5
Diabetic Macular Edema Treatment with Bevacizumab Does Not Depend on the Retinal Nonperfusion Presence. 61
33728349 2021
6
Late-Onset Kidney Biopsy-Associated Retroperitoneal Hemorrhage in Lupus Nephritis: A Case Report of Pseudoaneurysm and Microaneurysm Formations. 61
33708800 2021
7
Disparity of microaneurysm count between ultrawide field colour imaging and ultrawide field fluorescein angiography in eyes with diabetic retinopathy. 61
32111607 2020
8
Automatic Grading System for Diabetic Retinopathy Diagnosis Using Deep Learning Artificial Intelligence Software. 61
32410471 2020
9
Microaneurysm density in residual oedema after anti-vascular endothelial growth factor therapy for diabetic macular oedema. 61
33326191 2020
10
Successful Use of Tissue Plasminogen Activator for Saddle Pulmonary Embolism in Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage. 61
32971282 2020
11
Incorporating Optical Coherence Tomography Macula Scans Enhances Cost-effectiveness of Fundus Photography-Based Screening for Diabetic Macular Edema. 61
33004465 2020
12
Automatic microaneurysm detection in fundus image based on local cross-section transformation and multi-feature fusion. 61
32835957 2020
13
Microaneurysm detection in color eye fundus images for diabetic retinopathy screening. 61
33007620 2020
14
Quantitative Assessment of the Severity of Diabetic Retinopathy. 61
32446737 2020
15
A case of anti-VEGF therapy application in Takayasu arteries with retinopathy. 61
32923739 2020
16
Mathematical morphology for microaneurysm detection in fundus images. 61
31018679 2020
17
Longitudinal panretinal microaneurysm dynamics on ultra-widefield fluorescein angiography in eyes treated with intravitreal aflibercept for proliferative diabetic retinopathy in the recovery study. 61
32829304 2020
18
Analysis on diagnosing diabetic retinopathy by segmenting blood vessels, optic disc and retinal abnormalities. 61
32729345 2020
19
Retinal Artery Macroaneurysm Associated With Retinal Hemangioblastoma. 61
32579695 2020
20
Optical Coherence Tomography-Angiography of a large retinal microaneurysm. 61
32373757 2020
21
Observation of the far peripheral retina of normal eyes by ultra-wide field fluorescein angiography. 61
32452265 2020
22
Addressing class imbalance in deep learning for small lesion detection on medical images. 61
32250861 2020
23
Retinopathy Phenotypes in Type 2 Diabetes with Different Risks for Macular Edema and Proliferative Retinopathy. 61
32408522 2020
24
Repeatability of automated leakage quantification and microaneurysm identification utilising an analysis platform for ultra-widefield fluorescein angiography. 61
31320384 2020
25
Microaneurysms detection in color fundus images using machine learning based on directional local contrast. 61
32295576 2020
26
A multi-context CNN ensemble for small lesion detection. 61
32143786 2020
27
Long-term case study of a Wuzhishan miniature pig with diabetes. 61
32318656 2020
28
Microaneurysm Imaging Using Multiple En Face OCT Angiography Image Averaging: Morphology and Visualization. 61
31753811 2020
29
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY CHANGES AFTER SUBTHRESHOLD MICROPULSE YELLOW LASER IN DIABETIC MACULAR EDEMA. 61
31972802 2020
30
Diagnostic and therapeutic challenge in intracerebral hemorrhage due to aneurysm of distal lenticulostriate artery. 61
32538989 2020
31
The Effect of Anti-Vascular Endothelial Growth Factor on Retinal Microvascular Changes in Diabetic Macular Edema Using Swept-Source Optical Coherence Tomography Angiography. 61
33235428 2020
32
Quantitative Ultra-Widefield Angiographic Features and Associations with Diabetic Macular Edema. 61
31690541 2020
33
Retinopathy Analysis Based on Deep Convolution Neural Network. 61
32030666 2020
34
Prospective, Single-Center, Six-Month Study of Intravitreal Ranibizumab for Macular Edema with Nonproliferative Diabetic Retinopathy: Effects on Microaneurysm Turnover and Non-Perfused Retinal Area. 61
32606576 2020
35
Analysis of quantitative correlations between microaneurysm, ischaemic index and new vessels in ultrawide-field fluorescein angiography images using automated software. 61
30872285 2019
36
Lessons from the Trials for the Desirable Effects of Sodium Glucose Co-Transporter 2 Inhibitors on Diabetic Cardiovascular Events and Renal Dysfunction. 61
31726765 2019
37
Quantitative Ultra-Widefield Angiography and Diabetic Retinopathy Severity: An Assessment of Panretinal Leakage Index, Ischemic Index and Microaneurysm Count. 61
31383482 2019
38
In vivo rotational three-dimensional OCTA analysis of microaneurysms in the human diabetic retina. 61
31728070 2019
39
Vagus nerve stimulation protects against acute liver injury induced by renal ischemia reperfusion via antioxidant stress and anti-inflammation. 61
31177065 2019
40
[ZHENG' Guo-Yan-Re needling technique for diabetic fundus hemorrhage]. 61
31397130 2019
41
Detection of microaneurysms using ant colony algorithm in the early diagnosis of diabetic retinopathy. 61
31371092 2019
42
Onyx Embolization of Distal Middle Cerebral Artery Aneurysm in a Patient with Nontraumatic Subdural Hematoma. 61
31497128 2019
43
Diabetic retinopathy techniques in retinal images: A review. 61
30448367 2019
44
Microaneurysm detection in fundus images using a two-step convolutional neural network. 61
31142335 2019
45
Treatment of macular hemorrhage in retinal arterial microaneurysm: anatomic site-oriented therapy. 61
30783941 2019
46
ANALYSIS OF THE NORMAL PERIPHERAL RETINAL VASCULAR PATTERN AND ITS CORRELATION WITH MICROVASCULAR ABNORMALITIES USING ULTRA-WIDEFIELD FLUORESCEIN ANGIOGRAPHY. 61
29200099 2019
47
Microaneurysm turnover is a predictor of diabetic retinopathy progression. 61
29699981 2019
48
Image super-resolution using progressive generative adversarial networks for medical image analysis. 61
30472408 2019
49
Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation. 61
30359965 2019
50
Association of Microaneurysms on Adaptive Optics Scanning Laser Ophthalmoscopy With Surrounding Neuroretinal Pathology and Visual Function in Diabetes. 61
30481280 2018

Variations for Retinal Microaneurysm

Expression for Retinal Microaneurysm

Search GEO for disease gene expression data for Retinal Microaneurysm.

Pathways for Retinal Microaneurysm

Pathways related to Retinal Microaneurysm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.64 VEGFA INS
2
Show member pathways
10.25 VEGFA INS

GO Terms for Retinal Microaneurysm

Cellular components related to Retinal Microaneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 VEGFA REN MIR20A LOXL4 INS AKR1B1

Biological processes related to Retinal Microaneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 outflow tract morphogenesis GO:0003151 9.32 VEGFA MIR20A
2 cell maturation GO:0048469 9.26 VEGFA REN
3 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.16 VEGFA MIR20A
4 positive regulation of p38MAPK cascade GO:1900745 8.96 VEGFA GADD45G
5 positive regulation of protein autophosphorylation GO:0031954 8.62 VEGFA INS

Molecular functions related to Retinal Microaneurysm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor receptor binding GO:0005159 8.62 REN INS

Sources for Retinal Microaneurysm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....