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MCID: RTN002
MIFTS: 38

Retinal Perforation

Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Retinal Perforation

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MalaCards integrated aliases for Retinal Perforation:

Name: Retinal Perforation 12 15
Retinal Perforations 43 71
Retinal Dialysis 12
Retinal Break 12
Retinal Tear 12

Classifications:

MalaCards categories:
Anatomical: Eye diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:12514
MeSH 43 D012167
NCIt 49 C50732
SNOMED-CT 67 40024006 95690009
ICD10 32 H33.3
UMLS 71 C0035321
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Summaries for Retinal Perforation

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MalaCards based summary : Retinal Perforation, also known as retinal perforations, is related to vitreoretinopathy, neovascular inflammatory and microvascular complications of diabetes 5. An important gene associated with Retinal Perforation is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Lutein and Fibrinolysin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are nervous system and vision/eye

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Related Diseases for Retinal Perforation

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Diseases related to Retinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 166)
# Related Disease Score Top Affiliating Genes
1 vitreoretinopathy, neovascular inflammatory 30.7 VEGFA RPE65 RLBP1 FN1
2 microvascular complications of diabetes 5 30.4 VEGFA PLG PGF CRYAA
3 preretinal fibrosis 30.2 VEGFA RLBP1 FN1
4 macular retinal edema 30.1 VEGFB VEGFA PLG PGF
5 vitreoretinal degeneration 30.0 COL2A1 COL11A1
6 retinal degeneration 29.9 RS1 RPE65 RLBP1 CRYAA COL2A1
7 stickler syndrome 29.9 OPTC CRYAA COL2A1 COL11A2 COL11A1
8 retinal detachment 29.8 VEGFA RS1 COL2A1 COL11A1
9 mature cataract 29.8 CRYGS CRYAA
10 peripheral retinal degeneration 29.8 RLBP1 COL2A1
11 exudative vitreoretinopathy 1 29.6 VEGFB VEGFA PGF FN1 CRYAA
12 strabismus 29.6 RS1 CRYAA COL2A1 COL11A1
13 fundus dystrophy 29.5 VEGFA RS1 RPE65 RLBP1 CRYAA
14 cataract 29.4 VEGFA FN1 CRYGS CRYAA COL2A1 COL11A1
15 vitreous syneresis 29.4 OPTC CRYAA COL2A1 COL11A2 COL11A1
16 endophthalmitis 29.4 VEGFB VEGFA PLG PGF CRYAA
17 vitreous detachment 29.4 VEGFB VEGFA PLG OPTC LHFPL5 FN1
18 macular holes 29.2 VEGFA RS1 RPE65 PLG OPTC LHFPL5
19 myopia 29.1 VEGFA OPTC CRYAA COL2A1 COL11A2 COL11A1
20 neovascular glaucoma 28.5 VEGFB VEGFA RS1 PLG PGF NARF
21 macular degeneration, age-related, 1 28.2 VEGFB VEGFA RS1 RPE65 RLBP1 PLG
22 spondylometaphyseal dysplasia, corner fracture type 10.5 FN1 COL2A1
23 bullous retinoschisis 10.4 VEGFA RS1
24 stickler syndrome, type i, nonsyndromic ocular 10.4
25 vitreoretinopathy 10.4
26 otospondylomegaepiphyseal dysplasia, autosomal recessive 10.4 COL2A1 COL11A2
27 cancer-associated retinopathy 10.4 VEGFA PGF
28 epithelioid hemangioendothelioma 10.3 VEGFA PGF
29 intraocular retinoblastoma 10.3 ESCO2 CRYAA
30 hypertensive encephalopathy 10.3 VEGFA PGF
31 hypochondrogenesis 10.3 COL2A1 COL11A2
32 severe nonproliferative diabetic retinopathy 10.3 VEGFA PGF
33 corneal disease 10.3 VEGFA FN1 CRYAA
34 glaucoma, primary open angle 10.3 OPTC FN1 CRYAA
35 erysipeloid 10.3 PLG FN1
36 severe pre-eclampsia 10.3 VEGFA PGF FN1
37 branch retinal artery occlusion 10.3 VEGFA PLG
38 marshall syndrome 10.3 COL2A1 COL11A1
39 diabetic macular edema 10.3 VEGFB VEGFA PGF
40 central retinal artery occlusion 10.3 VEGFA PLG CRYAA
41 malignant renovascular hypertension 10.3 VEGFB PGF
42 eye degenerative disease 10.3 VEGFA RS1 CRYAA COL2A1
43 leukocoria 10.3 ESCO2 CRYAA
44 vitreoretinal dystrophy 10.3 RS1 COL11A1
45 corneal neovascularization 10.2 VEGFA PLG CRYAA
46 fibrochondrogenesis 1 10.2 COL11A2 COL11A1
47 early-onset lamellar cataract 10.2 CRYGS CRYAA
48 rubeosis iridis 10.2 VEGFA PLG DHDH
49 malignant hypertensive renal disease 10.2 VEGFB PGF
50 osteonecrosis 10.2 VEGFA PLG COL2A1

Graphical network of the top 20 diseases related to Retinal Perforation:



Diseases related to Retinal Perforation
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Symptoms & Phenotypes for Retinal Perforation

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MGI Mouse Phenotypes related to Retinal Perforation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.7 COL11A1 COL2A1 ESCO2 FN1 LHFPL5 PLG
2 vision/eye MP:0005391 9.32 COL2A1 CRYGS OPTC PGF PLG RLBP1
Sources

Drugs & Therapeutics for Retinal Perforation

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Drugs for Retinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lutein Approved, Investigational, Nutraceutical Phase 3 127-40-2 6433159
2
Fibrinolysin Investigational Phase 3 9004-09-5
3 Fibrinolytic Agents Phase 3
4
Ranibizumab Approved Phase 2 347396-82-1 459903
5 Angiogenesis Inhibitors Phase 2
6 Mitogens Phase 2
7 Pharmaceutical Solutions Phase 2
8 Ophthalmic Solutions Phase 2
9
Ursodeoxycholic acid Approved, Investigational Phase 1 128-13-2 31401
10 Gastrointestinal Agents Phase 1
11 Cholagogues and Choleretics Phase 1
12
Bevacizumab Approved, Investigational 216974-75-3
13
Methylprednisolone Approved, Vet_approved 83-43-2 6741
14
Prednisolone Approved, Vet_approved 50-24-8 5755
15
Methylprednisolone hemisuccinate Approved 2921-57-5
16 Prednisolone acetate Approved, Vet_approved 52-21-1
17
Prednisolone phosphate Approved, Vet_approved 302-25-0
18
Dipivefrin Approved 52365-63-6 3105
19
Timolol Approved 26839-75-8 33624 5478
20
Dorzolamide Approved 120279-96-1 3154 5284549
21
Triamcinolone Approved, Vet_approved 124-94-7 31307
22
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
23
tannic acid Approved 1401-55-4
24
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
25
Temazepam Approved, Investigational 846-50-4 5391
26
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
27
Prednisolone hemisuccinate Experimental 2920-86-7
28
Diminazene Experimental 536-71-0
29 Antineoplastic Agents, Immunological
30 Antiemetics
31 Methylprednisolone Acetate
32 Hormone Antagonists
33 Anti-Inflammatory Agents
34 Autonomic Agents
35 Neuroprotective Agents
36 Protective Agents
37 Antineoplastic Agents, Hormonal
38 glucocorticoids
39 Hormones
40 Diminazene aceturate
41 Antiparasitic Agents
42 Antiprotozoal Agents
43 Anti-Infective Agents
44 Anti-Arrhythmia Agents
45 Adrenergic Antagonists
46 Adrenergic beta-Antagonists
47 Antihypertensive Agents
48 Carbonic Anhydrase Inhibitors
49 Adrenergic Agents
50 Triamcinolone hexacetonide

Interventional clinical trials:

(show top 50) (show all 112)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-masked, Multicenter, Controlled Study of Effects of Internal Membrane Peeling Surgery in Patients With Idiopathic Macular Hole Measured by Optical Coherence Tomography. Unknown status NCT02905409 Phase 4
2 A Randomized, Comparative, Prospective Study of Anatomical Outcomes With Different Internal Limiting Membrane Peeling Area in Surgery for Idiopathic Macular Hole Completed NCT02930369 Phase 4
3 Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Macular Edema in Subjects Who Completed the Three Year VISTA-DME Trial (The Endurance 1 Trial) Completed NCT02297204 Phase 4 aflibercept 2.0 mg
4 A Randomized Study Comparing Brilliant Blue and Indocyanine Green as Intravitreal Dye in Macular Pucker and Macular Hole Unknown status NCT01083004 Phase 3
5 Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery Unknown status NCT01820520 Phase 3 brilliant blue G
6 A Randomized, Sham-controlled, Double-masked, Multicenter Study Evaluating Ocriplasmin Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole Completed NCT01429441 Phase 3 Ocriplasmin
7 A Descriptive Study to Evaluate the Effectiveness of the Dye Compound of the Combination of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy Completed NCT01627977 Phase 3
8 Comparison of Air and Expansile Gas in Pneumatic Retinopexy Completed NCT00120445 Phase 3
9 Analysis of Vitreous and Aqueous Humor for Ocular Growth Factors, Cytokines, Chemokines, and Ranibizumab Pharmacokinetics Associated With Various Retinal Disease Unknown status NCT02067013 Phase 2 Ranibizumab
10 Intravitreal Decorin Preventing Proliferative Vitreoretinopathy in Perforating Injuries: a Pilot Study. Completed NCT02865031 Phase 1, Phase 2 Decorin
11 Single-Arm Study Assessing the Effects of Pneumatic Vitreolysis on Macular Hole Recruiting NCT03677869 Phase 2
12 A Randomized, Double-Masked, Placebo Controlled, Parallel Group, Multi-Center, Dose-Ranging Study of Denufosol Tetrasodium (INS37217) Intravitreal Injection in Subjects With Rhegmatogenous Retinal Detachment Terminated NCT00083967 Phase 2 denufosol tetrasodium (INS37217) Intravitreal Injection
13 Phase 2 Study of OT-551 Ophthalmic Solution to Prevent or Delay Progression of Nuclear Cataract Formation In Post-Vitrectomy Patients Terminated NCT00333060 Phase 2 OT-551 ophthalmic solution
14 Partial Posterior Hyaloidectomy in Macular Surgery : A Modified Procedure of Vitrectomy to Prevent Retinal Break Related to Induction of a Posterior Vitreous Detachment Completed NCT01454466 Phase 1
15 Ursodeoxycholic Acid (UDCA) as Adjuvant Treatment for Rhegmatogenous Retinal Detachment: a Phase I Pilot Study Completed NCT02841306 Phase 1 Ursodeoxycholic Acid
16 Early Vitrectomy for Impending Macular Hole. Multicenter Clinical Trial Unknown status NCT01121965
17 Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy Unknown status NCT01969929
18 Corneal Endothelial Cell Loss After Pneumatic Retinopexy for the Repair of Primary Rhegmatogenous Retinal Detachment Unknown status NCT02185469 sulfur hexafluoride (SF6)
19 The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes Unknown status NCT02081170
20 Short Term Postoperative Tamponade Using Perfluorocarbon Liquid for Giant Retinal Tears Unknown status NCT01604616
21 Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis Unknown status NCT01687829
22 Surgical Inverted ILM Repositioning as Autologous Dressing for Idiopathic Full Thickness Macular Holes Treatment Unknown status NCT01228188
23 Effect of Intravitreal Bevacizumab on Early Post-Vitrectomy Hemorrhage in Diabetic Patients Unknown status NCT00524875 Bevacizumab
24 Evaluation Use Optical Coherence Tomography - Rescan During Dissection of Macular Membranes : Pre and Post Operative Aspects Unknown status NCT02748421
25 Topical Use of Corticosteroid to Prevent Epiretinal Membrane Formation in Eyes With Retinal Tear Undergoing Laser Retinopexy: a Pilot Prospective Clinical Study Completed NCT02412059 Prednisolone acetate
26 Comparison of Vitrectomy Without Internal Limiting Membrane Peeling Versus Inverted ILM Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes Completed NCT04011007
27 Impact of C3F8 or SF6 Use and Length of Face-down Positioning (7 vs 14 Days Respectively) in Macular Hole Surgery Completed NCT02073266
28 Outcome of Surgery for Idiopathic Macular Holes Completed NCT02895594
29 The Eye Hospital of Tianjin Medical University Completed NCT02584062
30 Comparison of Macular Function and Visual Fields After Membrane Blue or Infracyanine Green Staining in Vitreoretinal Surgery Completed NCT00555269
31 Asymmetrical Recovery of Cone Outer Segment Tips and Foveal Displacement After Macular Hole Surgery Completed NCT01959776
32 Membranepeeling With Brillant Blue Versus Membranepeeling With Indocyanine Green for Patients With Idiopathic Macular Holes. Completed NCT00757471
33 Observational Study On Retinal Structure And Function Before And After Epimacular Membrane Peeling Completed NCT01083056
34 Long-term Outcome of Idiopathic Macular Hole Surgery Completed NCT00941291
35 Long-term Anatomical and Functional Outcomes of Idiopathic Macular Hole Surgery. The Yield of Spectral-domain OCT Combined With Microperimetry. Completed NCT01757600
36 Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies Completed NCT00408720
37 Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole Completed NCT01226160 Early Phase 1
38 Efficacy of Surgical Treatment of Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy Completed NCT02528045
39 The Application of M-charts and Microperimetry for the Assessment of Visual Function in Patients After Vitrectomy Due to the Full Thickness Macular Hole. Completed NCT03701542
40 Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO Completed NCT01692938
41 Traumatic Macular Hole: Six-months Observation Versus Early Surgical Intervention, A Multicenter Clinical Trial Completed NCT01509092
42 To Peel or Not to Peel: Surgical Outcome of Macular Membrane Peeling Associated With Significant Macular Drusen Completed NCT03927430
43 Preoperative Progression of Macular Holes Using Optical Coherence Tomography Completed NCT02203929
44 Macular Hole and Cataract Extraction: Combined Surgery Versus Two Times Surgery Completed NCT01069029
45 Epiretinal Proliferation in Eyes With Full Thickness Macular Hole Completed NCT03376776
46 Fundus Autofluorescence Images in Gas-filled Eyes Immediately After Macular Hole Surgery Completed NCT02628262
47 Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy Completed NCT02528058
48 Blue Light-Filter IOLs in Vitrectomy Combined With Cataract Surgery: Results of a Randomized Controlled Clinical Trial. Completed NCT00537992
49 Internal Limiting Membrane Flap in the Management of Retinal Detachment Due to Paracentral Retinal Breaks Completed NCT03707015
50 Efficacy of Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes Completed NCT02896972

Search NIH Clinical Center for Retinal Perforation

Cochrane evidence based reviews: retinal perforations

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Genetic Tests for Retinal Perforation

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Anatomical Context for Retinal Perforation

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MalaCards organs/tissues related to Retinal Perforation:

40
Eye, Retina, Endothelial, Bone
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Publications for Retinal Perforation

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Articles related to Retinal Perforation:

(show all 33)
# Title Authors PMID Year
1
Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach. 61
28596284 2017
2
Experience With a Subretinal Cell-based Therapy in Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration. 61
28435054 2017
3
Malignant choroidal melanoma with suspected vitreous seeding - A case report. 61
29034158 2017
4
Iatrogenic subretinal injection of Ozurdex® implant and its effect on macular edema. 61
28757695 2017
5
Epiretinal membrane in a subject after transvitreal delivery of palucorcel (CNTO 2476). 61
29070939 2017
6
[Retinal perforation by a hard silicone buckle 20 years after retinal detachment surgery with an encircling buckle]. 61
26549138 2015
7
Bimodal in vivo imaging provides early assessment of stem-cell-based photoreceptor engraftment. 61
25771816 2015
8
Staining internal limiting membrane with a mixture of BBG and sodium hyaluronate. 61
23203697 2013
9
Vitrectomy and internal limiting membrane peeling of a traumatic macular hole with retinal folds. 61
21475605 2011
10
A Perforating Eye Injury Caused by a Staple Gun, Treated Successfully Without Vitrectomy. 61
20337334 2010
11
Transscleral fine-needle aspiration biopsy of macular choroidal melanoma. 61
18062935 2008
12
[Forensic medical assessment in post-trauma retinal detachment]. 61
17896515 2007
13
An age-based method for planning sclerotomy placement during pediatric vitrectomy: a 12-year experience. 61
18427597 2007
14
Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. 61
16942444 2006
15
A new instrument for drainage or injection of fluid within subretinal space. 61
14574251 2003
16
Locally invasive tumors arising from hyperplasia of the retinal pigment epithelium. 61
11642378 2001
17
A study of the ability of tissue plasminogen activator to diffuse into the subretinal space after intravitreal injection in rabbits. 61
10612511 1999
18
Retinal complications of strabismus surgery. 61
10182101 1998
19
External argon laser choroidotomy for subretinal fluid drainage. 61
9524028 1998
20
Retinal perforation in strabismus surgery. 61
9083958 1997
21
Indirect argon laser drainage of subretinal fluid. 61
8944099 1996
22
Prospective, randomised, controlled trial comparing suture needle drainage and argon laser drainage of subretinal fluid. 61
7547781 1995
23
[Retinal detachment and laser drainage]. 61
7609379 1995
24
Drainage of subretinal fluid with the argon laser. 61
8506910 1993
25
[Postoperative posture of patients with retinal perforation treated with pneumatic retinopexy]. 61
8258183 1993
26
Use of the carbon dioxide laser in the drainage of subretinal fluid. 61
2497717 1989
27
Natural history of penetrating ocular injury with retinal laceration in the monkey. 61
3943726 1986
28
Argon laser choroidotomy for drainage of subretinal fluid. 61
3977722 1985
29
Choroidal melanoma with retinal perforation and vitreous hemorrhage: a scanning electron microscopic study. 61
6656013 1983
30
Pseudoretinitis pigmentosa secondary to preretinal malignant melanoma cells. 61
7178677 1982
31
Aspiration from the vitreous of a non-magnetic foreign body. 61
718819 1978
32
Retinal perforation and muscle surgery. 61
5481593 1970
33
[A spot suggesting retinal perforation]. 61
14957388 1952
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Variations for Retinal Perforation

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Expression for Retinal Perforation

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Search GEO for disease gene expression data for Retinal Perforation.
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Pathways for Retinal Perforation

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Pathways related to Retinal Perforation according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Phospholipase-C Pathway 63
Show member pathways
 12.77 VEGFB PGF FN1 COL2A1 COL11A2 COL11A1
2
Degradation of the extracellular matrix 65
Show member pathways
 12.29 PLG OPTC FN1 COL2A1 COL11A2 COL11A1
3
VEGF Pathway (Qiagen) 63
Show member pathways
 12.17 VEGFB VEGFA PGF FN1
4
Focal Adhesion 1 36
Show member pathways
 11.93 VEGFB VEGFA PGF FN1 COL2A1 COL11A2
5
AGE-RAGE signaling pathway in diabetic complications 36
11.65 VEGFB VEGFA FN1
6
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.6 VEGFB VEGFA PGF
7
Cell adhesion_ECM remodeling 22
11.33 PLG FN1 COL2A1
8
Cell adhesion_Plasmin signaling 22
11.19 VEGFA PLG FN1
9
G-protein signaling_Rap2B regulation pathway 22
10.64 VEGFB PGF FN1 COL2A1 COL11A2 COL11A1
10
miR-148a/miR-31/FIH1/HIF1andalpha;-Notch signaling in glioblastoma 1
10.39 VEGFB VEGFA
11
VEGF binds to VEGFR leading to receptor dimerization 65
Show member pathways
 10.34 VEGFB VEGFA PGF
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GO Terms for Retinal Perforation

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Cellular components related to Retinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 VEGFB VEGFA RS1 PLG PGF FN1
2 extracellular region GO:0005576 9.96 VEGFB VEGFA RS1 PLG PGF OPTC
3 collagen-containing extracellular matrix GO:0062023 9.77 PLG FN1 COL2A1 COL11A2 COL11A1
4 endoplasmic reticulum lumen GO:0005788 9.73 FN1 COL2A1 COL11A2 COL11A1
5 collagen trimer GO:0005581 9.58 COL2A1 COL11A2 COL11A1
6 platelet alpha granule lumen GO:0031093 9.26 VEGFB VEGFA PLG FN1
7 collagen type XI trimer GO:0005592 9.16 COL11A2 COL11A1
8 extracellular matrix GO:0031012 9.1 VEGFA OPTC FN1 COL2A1 COL11A2 COL11A1

Biological processes related to Retinal Perforation according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.89 VEGFB VEGFA PGF FN1
2 extracellular matrix organization GO:0030198 9.88 FN1 COL2A1 COL11A2 COL11A1
3 cartilage development GO:0051216 9.76 COL2A1 COL11A2 COL11A1
4 positive regulation of endothelial cell proliferation GO:0001938 9.74 VEGFB VEGFA PGF
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.71 VEGFB VEGFA PGF
6 heart morphogenesis GO:0003007 9.69 VEGFA COL2A1 COL11A1
7 positive chemotaxis GO:0050918 9.67 VEGFB VEGFA PGF
8 platelet degranulation GO:0002576 9.67 VEGFB VEGFA PLG FN1
9 collagen fibril organization GO:0030199 9.65 COL2A1 COL11A2 COL11A1
10 positive regulation of cell division GO:0051781 9.61 VEGFB VEGFA PGF
11 detection of mechanical stimulus involved in sensory perception of sound GO:0050910 9.6 LHFPL5 COL11A1
12 skeletal system morphogenesis GO:0048705 9.58 COL2A1 COL11A2 COL11A1
13 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.56 VEGFA PLG
14 proteoglycan metabolic process GO:0006029 9.55 COL2A1 COL11A1
15 vitamin A metabolic process GO:0006776 9.52 RPE65 RLBP1
16 sprouting angiogenesis GO:0002040 9.5 VEGFB VEGFA PGF
17 interaction with symbiont GO:0051702 9.46 PLG FN1
18 vascular endothelial growth factor signaling pathway GO:0038084 9.43 VEGFB VEGFA PGF
19 induction of positive chemotaxis GO:0050930 9.33 VEGFB VEGFA PGF
20 visual perception GO:0007601 9.17 RS1 RPE65 RLBP1 CRYGS CRYAA COL2A1
21 positive regulation of mast cell chemotaxis GO:0060754 9.13 VEGFB VEGFA PGF

Molecular functions related to Retinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 9.55 VEGFB VEGFA PGF FN1 COL11A1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.54 COL2A1 COL11A2 COL11A1
3 chemoattractant activity GO:0042056 9.5 VEGFB VEGFA PGF
4 proteoglycan binding GO:0043394 9.4 FN1 COL2A1
5 extracellular matrix structural constituent GO:0005201 9.35 OPTC FN1 COL2A1 COL11A2 COL11A1
6 vascular endothelial growth factor receptor 1 binding GO:0043183 9.26 VEGFB VEGFA
7 vascular endothelial growth factor receptor binding GO:0005172 8.8 VEGFB VEGFA PGF
Sources

Sources for Retinal Perforation

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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