MCID: RTN002
MIFTS: 38

Retinal Perforation

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Perforation

MalaCards integrated aliases for Retinal Perforation:

Name: Retinal Perforation 12 15
Retinal Perforations 43 71
Retinal Break 12 17
Retinal Dialysis 12
Retinal Tear 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12514
MeSH 43 D012167
NCIt 49 C50732
SNOMED-CT 67 232003005
ICD10 32 H33.3
UMLS 71 C0035321

Summaries for Retinal Perforation

MalaCards based summary : Retinal Perforation, also known as retinal perforations, is related to vitreoretinopathy, neovascular inflammatory and microvascular complications of diabetes 5. An important gene associated with Retinal Perforation is CRYAA (Crystallin Alpha A), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Fentanyl and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Retinal Perforation

Diseases related to Retinal Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 vitreoretinopathy, neovascular inflammatory 30.5 VEGFA RPE65 RLBP1 FN1 CRYAA
2 microvascular complications of diabetes 5 30.3 VEGFA PLG PGF CRYAA
3 vitreoretinal degeneration 30.2 COL2A1 COL11A1
4 stickler syndrome 30.1 OPTC CRYAA COL2A1 COL11A2 COL11A1
5 preretinal fibrosis 30.1 VEGFA RLBP1 FN1
6 mature cataract 30.1 CRYGS CRYBB2 CRYAA
7 retinal detachment 30.0 VEGFA RS1 COL2A1 COL11A1
8 retinal degeneration 29.9 RS1 RPE65 RLBP1 CRYAA COL2A1
9 macular retinal edema 29.9 VEGFB VEGFA PGF CRYAA
10 vitreous detachment 29.8 VEGFB VEGFA PLG OPTC FN1 DHDH
11 background diabetic retinopathy 29.7 VEGFB VEGFA PGF
12 strabismus 29.7 RS1 CRYAA COL2A1 COL11A1
13 peripheral retinal degeneration 29.7 RLBP1 COL2A1
14 retinal lattice degeneration 29.5 CYLC2 COL2A1
15 exudative vitreoretinopathy 1 29.5 VEGFB VEGFA PGF CRYAA
16 macular holes 29.3 VEGFA RS1 RPE65 RLBP1 PLG OPTC
17 cataract 29.1 VEGFA FN1 CRYGS CRYBB2 CRYBA4 CRYAA
18 neovascular glaucoma 28.9 VEGFB VEGFA RS1 PLG PGF CRYAA
19 fundus dystrophy 28.9 VEGFA RS1 RPE65 RLBP1 FN1 CRYAA
20 endophthalmitis 28.8 VEGFB VEGFA RPE65 PLG PGF CRYAA
21 myopia 28.7 VEGFA OPTC CRYBA4 CRYAA COL2A1 COL11A2
22 vitreous syneresis 28.7 RS1 OPTC CYLC2 COL2A1 COL11A2 COL11A1
23 macular degeneration, age-related, 1 28.0 VEGFB VEGFA RS1 RPE65 RLBP1 PLG
24 stickler syndrome, type i, nonsyndromic ocular 10.4
25 bullous retinoschisis 10.4 VEGFA RS1
26 spondylometaphyseal dysplasia, corner fracture type 10.4 FN1 COL2A1
27 vitreoretinopathy 10.4
28 morgagni cataract 10.4 CRYGS CRYAA
29 early-onset sutural cataract 10.4 CRYGS CRYBB2
30 fibrochondrogenesis 1 10.3 COL11A2 COL11A1
31 cataract 9, multiple types 10.3 CRYBB2 CRYAA
32 diabetic cataract 10.3 VEGFA CRYGS CRYAA
33 disuse amblyopia 10.3 CRYGS CRYAA
34 choroid disease 10.3 VEGFA RS1 RPE65
35 leukocoria 10.3 RS1 CRYAA
36 hereditary retinal dystrophy 10.3 RS1 RPE65 CRYAA
37 branch retinal artery occlusion 10.3 VEGFA PLG CRYAA
38 central retinal artery occlusion 10.3 VEGFA PLG CRYAA
39 erysipeloid 10.3 PLG FN1
40 glaucoma, primary open angle 10.3 OPTC FN1 CRYAA
41 uveal disease 10.3 VEGFA RPE65 CRYAA
42 kohler's disease 10.3 COL2A1 COL11A2 COL11A1
43 cancer-associated retinopathy 10.3 VEGFA PGF
44 kniest dysplasia 10.3 COL2A1 COL11A2 COL11A1
45 macroglossia 10.3 COL2A1 COL11A1
46 otospondylomegaepiphyseal dysplasia, autosomal dominant 10.3 COL2A1 COL11A2 COL11A1
47 schneckenbecken dysplasia 10.2 COL2A1 COL11A2 COL11A1
48 marshall syndrome 10.2 COL2A1 COL11A2 COL11A1
49 otospondylomegaepiphyseal dysplasia, autosomal recessive 10.2 COL2A1 COL11A2 COL11A1
50 corneal neovascularization 10.2 VEGFA PLG CRYAA

Graphical network of the top 20 diseases related to Retinal Perforation:



Diseases related to Retinal Perforation

Symptoms & Phenotypes for Retinal Perforation

GenomeRNAi Phenotypes related to Retinal Perforation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.36 COL11A1 OPTC
2 Decreased viability GR00249-S 9.36 COL11A1 CRYAA TCERG1 VEGFA
3 Decreased viability GR00381-A-1 9.36 RLBP1 TCERG1
4 Decreased viability GR00386-A-1 9.36 COL11A1 CRYBB2
5 Decreased viability GR00402-S-2 9.36 CRYAA

MGI Mouse Phenotypes related to Retinal Perforation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.36 COL2A1 CRYBB2 CRYGS OPTC PGF PLG

Drugs & Therapeutics for Retinal Perforation

Drugs for Retinal Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Triazolam Approved, Investigational Phase 4 28911-01-5 5556
6
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
7 Proxymetacaine Phase 4
8 Anesthetics Phase 4
9 Hypnotics and Sedatives Phase 4
10
Lutein Approved, Investigational, Nutraceutical Phase 3 127-40-2 6433159
11
Ranibizumab Approved Phase 2 347396-82-1 459903
12 Angiogenesis Inhibitors Phase 2
13 Mitogens Phase 2
14 Pharmaceutical Solutions Phase 2
15 Ophthalmic Solutions Phase 2
16
Ursodeoxycholic acid Approved, Investigational Phase 1 128-13-2 31401
17 Gastrointestinal Agents Phase 1
18
Bevacizumab Approved, Investigational 216974-75-3
19
Prednisolone phosphate Approved, Vet_approved 302-25-0
20
Methylprednisolone Approved, Vet_approved 83-43-2 6741
21
Methylprednisolone hemisuccinate Approved 2921-57-5
22
Prednisolone Approved, Vet_approved 50-24-8 5755
23 Prednisolone acetate Approved, Vet_approved 52-21-1
24
Dipivefrin Approved 52365-63-6 3105
25
Dorzolamide Approved 120279-96-1 5284549 3154
26
Timolol Approved 26839-75-8 5478 33624
27
Triamcinolone Approved, Vet_approved 124-94-7 31307
28
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
29
tannic acid Approved 1401-55-4
30
Benzocaine Approved, Investigational 94-09-7, 1994-09-7 2337
31
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
32
Prednisolone hemisuccinate Experimental 2920-86-7
33 Antineoplastic Agents, Immunological
34 Hormones
35 Antineoplastic Agents, Hormonal
36 Methylprednisolone Acetate
37 Hormone Antagonists
38 glucocorticoids
39 Neuroprotective Agents
40 Antiemetics
41 Protective Agents
42 Anti-Inflammatory Agents
43 Diminazene aceturate
44 Adrenergic beta-Antagonists
45 Antihypertensive Agents
46 Adrenergic Agents
47 Adrenergic Antagonists
48 Anti-Arrhythmia Agents
49 Carbonic Anhydrase Inhibitors
50 Neurotransmitter Agents

Interventional clinical trials:

(show top 50) (show all 116)
# Name Status NCT ID Phase Drugs
1 A Randomized, Comparative, Prospective Study of Anatomical Outcomes With Different Internal Limiting Membrane Peeling Area in Surgery for Idiopathic Macular Hole Completed NCT02930369 Phase 4
2 Long-Term Efficacy and Safety of Intravitreal Aflibercept Injections for the Treatment of Diabetic Macular Edema in Subjects Who Completed the Three Year VISTA-DME Trial (The Endurance 1 Trial) Completed NCT02297204 Phase 4 aflibercept 2.0 mg
3 A Randomized, Double-masked, Multicenter, Controlled Study of Effects of Internal Membrane Peeling Surgery in Patients With Idiopathic Macular Hole Measured by Optical Coherence Tomography. Recruiting NCT02905409 Phase 4
4 Comparative Analysis of Oral Sedation Versus Standard Intravenous Sedation in Vitreoretinal Surgery With Topical Anesthesia and Sub-tenon's Block Not yet recruiting NCT04346095 Phase 4 Oral Sedatives with or Without Analgesia;Intravenous Sedatives with or Without Analgesia
5 A Randomized Study Comparing Brilliant Blue and Indocyanine Green as Intravitreal Dye in Macular Pucker and Macular Hole Unknown status NCT01083004 Phase 3
6 Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery Unknown status NCT01820520 Phase 3 brilliant blue G
7 A Randomized, Sham-controlled, Double-masked, Multicenter Study Evaluating Ocriplasmin Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole Completed NCT01429441 Phase 3 Ocriplasmin
8 A Descriptive Study to Evaluate the Effectiveness of the Dye Compound of the Combination of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy Completed NCT01627977 Phase 3
9 Comparison of Air and Expansile Gas in Pneumatic Retinopexy Completed NCT00120445 Phase 3
10 Analysis of Vitreous and Aqueous Humor for Ocular Growth Factors, Cytokines, Chemokines, and Ranibizumab Pharmacokinetics Associated With Various Retinal Disease Unknown status NCT02067013 Phase 2 Ranibizumab
11 Intravitreal Decorin Preventing Proliferative Vitreoretinopathy in Perforating Injuries: a Pilot Study. Completed NCT02865031 Phase 1, Phase 2 Decorin
12 Single-Arm Study Assessing the Effects of Pneumatic Vitreolysis on Macular Hole Active, not recruiting NCT03677869 Phase 2
13 A Randomized, Double-Masked, Placebo Controlled, Parallel Group, Multi-Center, Dose-Ranging Study of Denufosol Tetrasodium (INS37217) Intravitreal Injection in Subjects With Rhegmatogenous Retinal Detachment Terminated NCT00083967 Phase 2 denufosol tetrasodium (INS37217) Intravitreal Injection
14 Phase 2 Study of OT-551 Ophthalmic Solution to Prevent or Delay Progression of Nuclear Cataract Formation In Post-Vitrectomy Patients Terminated NCT00333060 Phase 2 OT-551 ophthalmic solution
15 Partial Posterior Hyaloidectomy in Macular Surgery : A Modified Procedure of Vitrectomy to Prevent Retinal Break Related to Induction of a Posterior Vitreous Detachment Completed NCT01454466 Phase 1
16 Ursodeoxycholic Acid (UDCA) as Adjuvant Treatment for Rhegmatogenous Retinal Detachment: a Phase I Pilot Study Completed NCT02841306 Phase 1 Ursodeoxycholic Acid
17 Early Vitrectomy for Impending Macular Hole. Multicenter Clinical Trial Unknown status NCT01121965
18 Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy Unknown status NCT01969929
19 Corneal Endothelial Cell Loss After Pneumatic Retinopexy for the Repair of Primary Rhegmatogenous Retinal Detachment Unknown status NCT02185469 sulfur hexafluoride (SF6)
20 Short Term Postoperative Tamponade Using Perfluorocarbon Liquid for Giant Retinal Tears Unknown status NCT01604616
21 The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes Unknown status NCT02081170
22 Macular Hole Surgery With and Without Internal Limiting Membrane Peeling:A Systematic Review and Meta-analysis Unknown status NCT01687829
23 A Single Center, Randomized and Controlled Clinical Study of Inverted Internal Limiting Membrane Insertion Combined With Air Tamponade in the Treatment of Macular Hole Retinal Detachment in High Myopia Unknown status NCT03383731
24 Dissociated Optic Nerve Fiber Layer Appearance and Retinal Sensitivity After Macular Hole Surgery With Temporal Inverted Internal Limiting Membrane Flap Technique Unknown status NCT03287102
25 Surgical Inverted ILM Repositioning as Autologous Dressing for Idiopathic Full Thickness Macular Holes Treatment Unknown status NCT01228188
26 Effect of Intravitreal Bevacizumab on Early Post-Vitrectomy Hemorrhage in Diabetic Patients Unknown status NCT00524875 Bevacizumab
27 Evaluation Use Optical Coherence Tomography - Rescan During Dissection of Macular Membranes : Pre and Post Operative Aspects Unknown status NCT02748421
28 Topical Use of Corticosteroid to Prevent Epiretinal Membrane Formation in Eyes With Retinal Tear Undergoing Laser Retinopexy: a Pilot Prospective Clinical Study Completed NCT02412059 Prednisolone acetate
29 Comparison of Vitrectomy Without Internal Limiting Membrane Peeling Versus Inverted ILM Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes Completed NCT04011007
30 Impact of C3F8 or SF6 Use and Length of Face-down Positioning (7 vs 14 Days Respectively) in Macular Hole Surgery Completed NCT02073266
31 The Eye Hospital of Tianjin Medical University Completed NCT02584062
32 Outcome of Surgery for Idiopathic Macular Holes Completed NCT02895594
33 Long-term Anatomical and Functional Outcomes of Idiopathic Macular Hole Surgery. The Yield of Spectral-domain OCT Combined With Microperimetry. Completed NCT01757600
34 Membranepeeling With Brillant Blue Versus Membranepeeling With Indocyanine Green for Patients With Idiopathic Macular Holes. Completed NCT00757471
35 Asymmetrical Recovery of Cone Outer Segment Tips and Foveal Displacement After Macular Hole Surgery Completed NCT01959776
36 Comparison of Macular Function and Visual Fields After Membrane Blue or Infracyanine Green Staining in Vitreoretinal Surgery Completed NCT00555269
37 Observational Study On Retinal Structure And Function Before And After Epimacular Membrane Peeling Completed NCT01083056
38 Long-term Outcome of Idiopathic Macular Hole Surgery Completed NCT00941291
39 Comparison of a Spectral OCT/SLO With the Stratus OCT for Imaging Various Retinal Pathologies Completed NCT00408720
40 Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole Completed NCT01226160 Early Phase 1
41 Fundus Autofluorescence Images in Gas-filled Eyes Immediately After Macular Hole Surgery Completed NCT02628262
42 Preoperative Progression of Macular Holes Using Optical Coherence Tomography Completed NCT02203929
43 Macular Hole and Cataract Extraction: Combined Surgery Versus Two Times Surgery Completed NCT01069029
44 Efficacy of Surgical Treatment of Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy Completed NCT02528045
45 Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO Completed NCT01692938
46 Traumatic Macular Hole: Six-months Observation Versus Early Surgical Intervention, A Multicenter Clinical Trial Completed NCT01509092
47 To Peel or Not to Peel: Surgical Outcome of Macular Membrane Peeling Associated With Significant Macular Drusen Completed NCT03927430
48 The Application of M-charts and Microperimetry for the Assessment of Visual Function in Patients After Vitrectomy Due to the Full Thickness Macular Hole. Completed NCT03701542
49 Epiretinal Proliferation in Eyes With Full Thickness Macular Hole Completed NCT03376776
50 Ultrastructure Analysis of Excised Internal Limiting Membrane in Eyes of Highly Myopia With Myopic Traction Maculopathy Completed NCT02528058

Search NIH Clinical Center for Retinal Perforation

Cochrane evidence based reviews: retinal perforations

Genetic Tests for Retinal Perforation

Anatomical Context for Retinal Perforation

MalaCards organs/tissues related to Retinal Perforation:

40
Eye, Retina, Endothelial

Publications for Retinal Perforation

Articles related to Retinal Perforation:

(show all 33)
# Title Authors PMID Year
1
Prognostic biopsy of choroidal melanoma: an optimised surgical and laboratory approach. 61
28596284 2017
2
Experience With a Subretinal Cell-based Therapy in Patients With Geographic Atrophy Secondary to Age-related Macular Degeneration. 61
28435054 2017
3
Malignant choroidal melanoma with suspected vitreous seeding - A case report. 61
29034158 2017
4
Iatrogenic subretinal injection of Ozurdex® implant and its effect on macular edema. 61
28757695 2017
5
Epiretinal membrane in a subject after transvitreal delivery of palucorcel (CNTO 2476). 61
29070939 2017
6
[Retinal perforation by a hard silicone buckle 20 years after retinal detachment surgery with an encircling buckle]. 61
26549138 2015
7
Bimodal in vivo imaging provides early assessment of stem-cell-based photoreceptor engraftment. 61
25771816 2015
8
Staining internal limiting membrane with a mixture of BBG and sodium hyaluronate. 61
23203697 2013
9
Vitrectomy and internal limiting membrane peeling of a traumatic macular hole with retinal folds. 61
21475605 2011
10
A Perforating Eye Injury Caused by a Staple Gun, Treated Successfully Without Vitrectomy. 61
20337334 2010
11
Transscleral fine-needle aspiration biopsy of macular choroidal melanoma. 61
18062935 2008
12
[Forensic medical assessment in post-trauma retinal detachment]. 61
17896515 2007
13
An age-based method for planning sclerotomy placement during pediatric vitrectomy: a 12-year experience. 61
18427597 2007
14
Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. 61
16942444 2006
15
A new instrument for drainage or injection of fluid within subretinal space. 61
14574251 2003
16
Locally invasive tumors arising from hyperplasia of the retinal pigment epithelium. 61
11642378 2001
17
A study of the ability of tissue plasminogen activator to diffuse into the subretinal space after intravitreal injection in rabbits. 61
10612511 1999
18
Retinal complications of strabismus surgery. 61
10182101 1998
19
External argon laser choroidotomy for subretinal fluid drainage. 61
9524028 1998
20
Retinal perforation in strabismus surgery. 61
9083958 1997
21
Indirect argon laser drainage of subretinal fluid. 61
8944099 1996
22
Prospective, randomised, controlled trial comparing suture needle drainage and argon laser drainage of subretinal fluid. 61
7547781 1995
23
[Retinal detachment and laser drainage]. 61
7609379 1995
24
Drainage of subretinal fluid with the argon laser. 61
8506910 1993
25
[Postoperative posture of patients with retinal perforation treated with pneumatic retinopexy]. 61
8258183 1993
26
Use of the carbon dioxide laser in the drainage of subretinal fluid. 61
2497717 1989
27
Natural history of penetrating ocular injury with retinal laceration in the monkey. 61
3943726 1986
28
Argon laser choroidotomy for drainage of subretinal fluid. 61
3977722 1985
29
Choroidal melanoma with retinal perforation and vitreous hemorrhage: a scanning electron microscopic study. 61
6656013 1983
30
Pseudoretinitis pigmentosa secondary to preretinal malignant melanoma cells. 61
7178677 1982
31
Aspiration from the vitreous of a non-magnetic foreign body. 61
718819 1978
32
Retinal perforation and muscle surgery. 61
5481593 1970
33
[A spot suggesting retinal perforation]. 61
14957388 1952

Variations for Retinal Perforation

Expression for Retinal Perforation

Search GEO for disease gene expression data for Retinal Perforation.

Pathways for Retinal Perforation

Pathways related to Retinal Perforation according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 VEGFB PGF FN1 COL2A1 COL11A2 COL11A1
2
Show member pathways
12.29 PLG OPTC FN1 COL2A1 COL11A2 COL11A1
3
Show member pathways
12.17 VEGFB VEGFA PGF FN1
4
Show member pathways
11.94 VEGFB VEGFA PGF FN1 COL2A1 COL11A2
5 11.65 VEGFB VEGFA FN1
6
Show member pathways
11.6 VEGFB VEGFA PGF
7 11.33 PLG FN1 COL2A1
8 11.19 VEGFA PLG FN1
9 10.64 VEGFB PGF FN1 COL2A1 COL11A2 COL11A1
10 10.39 VEGFB VEGFA
11
Show member pathways
10.34 VEGFB VEGFA PGF

GO Terms for Retinal Perforation

Cellular components related to Retinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.02 VEGFB VEGFA RS1 PLG PGF OPTC
2 extracellular space GO:0005615 9.91 VEGFB VEGFA RS1 PLG PGF FN1
3 collagen-containing extracellular matrix GO:0062023 9.77 PLG FN1 COL2A1 COL11A2 COL11A1
4 endoplasmic reticulum lumen GO:0005788 9.73 FN1 COL2A1 COL11A2 COL11A1
5 collagen trimer GO:0005581 9.58 COL2A1 COL11A2 COL11A1
6 platelet alpha granule lumen GO:0031093 9.26 VEGFB VEGFA PLG FN1
7 collagen type XI trimer GO:0005592 9.16 COL11A2 COL11A1
8 extracellular matrix GO:0031012 9.1 VEGFA OPTC FN1 COL2A1 COL11A2 COL11A1

Biological processes related to Retinal Perforation according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 10.01 RS1 RPE65 RLBP1 CRYBB2 CRYAA
2 angiogenesis GO:0001525 9.91 VEGFB VEGFA PGF FN1
3 extracellular matrix organization GO:0030198 9.9 FN1 COL2A1 COL11A2 COL11A1
4 cartilage development GO:0051216 9.77 COL2A1 COL11A2 COL11A1
5 positive regulation of endothelial cell proliferation GO:0001938 9.75 VEGFB VEGFA PGF
6 camera-type eye development GO:0043010 9.73 RPE65 CRYBB2 CRYBA4
7 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 VEGFB VEGFA PGF
8 heart morphogenesis GO:0003007 9.7 VEGFA COL2A1 COL11A1
9 positive chemotaxis GO:0050918 9.69 VEGFB VEGFA PGF
10 platelet degranulation GO:0002576 9.67 VEGFB VEGFA PLG FN1
11 positive regulation of cell division GO:0051781 9.65 VEGFB VEGFA PGF
12 skeletal system morphogenesis GO:0048705 9.63 COL2A1 COL11A2 COL11A1
13 lens development in camera-type eye GO:0002088 9.61 CRYGS CRYBB2 CRYBA4
14 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.58 VEGFA PLG
15 sprouting angiogenesis GO:0002040 9.58 VEGFB VEGFA PGF
16 proteoglycan metabolic process GO:0006029 9.57 COL2A1 COL11A1
17 vitamin A metabolic process GO:0006776 9.54 RPE65 RLBP1
18 vascular endothelial growth factor signaling pathway GO:0038084 9.5 VEGFB VEGFA PGF
19 interaction with symbiont GO:0051702 9.49 PLG FN1
20 collagen fibril organization GO:0030199 9.46 OPTC COL2A1 COL11A2 COL11A1
21 induction of positive chemotaxis GO:0050930 9.43 VEGFB VEGFA PGF
22 visual perception GO:0007601 9.28 RS1 RPE65 RLBP1 CRYGS CRYBB2 CRYBA4
23 positive regulation of mast cell chemotaxis GO:0060754 9.13 VEGFB VEGFA PGF

Molecular functions related to Retinal Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.97 VEGFB VEGFA TCERG1 PGF FN1 CRYBB2
2 heparin binding GO:0008201 9.65 VEGFB VEGFA PGF FN1 COL11A1
3 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.61 COL2A1 COL11A2 COL11A1
4 chemoattractant activity GO:0042056 9.58 VEGFB VEGFA PGF
5 extracellular matrix structural constituent GO:0005201 9.55 OPTC FN1 COL2A1 COL11A2 COL11A1
6 proteoglycan binding GO:0043394 9.46 FN1 COL2A1
7 vascular endothelial growth factor receptor 1 binding GO:0043183 9.37 VEGFB VEGFA
8 vascular endothelial growth factor receptor binding GO:0005172 9.13 VEGFB VEGFA PGF
9 structural constituent of eye lens GO:0005212 8.92 CRYGS CRYBB2 CRYBA4 CRYAA

Sources for Retinal Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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