MCID: RTN020
MIFTS: 54

Retinal Vascular Disease

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Vascular Disease

MalaCards integrated aliases for Retinal Vascular Disease:

Name: Retinal Vascular Disease 12 15
Retinal Vascular 55 73
Retina Circulation Disorder 12
Retinal Vascular Disorder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2462
NCIt 50 C35170
SNOMED-CT 68 57534004

Summaries for Retinal Vascular Disease

MalaCards based summary : Retinal Vascular Disease, also known as retinal vascular, is related to retinal vascular occlusion and central retinal vein occlusion, and has symptoms including chest pain An important gene associated with Retinal Vascular Disease is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and mTOR signaling pathway (KEGG). The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and retina, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Retinal Vascular Disease

Diseases related to Retinal Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 retinal vascular occlusion 33.7 CCL2 MTHFR PGF PLG VEGFA
2 central retinal vein occlusion 31.5 MTHFR SERPINF1 VEGFA
3 exudative vitreoretinopathy 31.4 FZD4 LRP5 NDP TSPAN12 ZNF408
4 vascular disease 31.0 ALB CCL2 INS MTHFR PLG VEGFA
5 coats disease 30.8 FZD4 KDR LRP5 NDP TSPAN12 VEGFA
6 retinal disease 30.4 AIPL1 ALB NDP
7 macular retinal edema 30.2 CCL2 ICAM1 VEGFA
8 exudative vitreoretinopathy 1 30.1 FZD4 KDR LRP5 NDP TSPAN12 VEGFA
9 diabetic macular edema 30.1 CCL2 ICAM1 SERPINF1 VEGFA
10 leukostasis 30.0 ICAM1 KDR VEGFA
11 retinal vein occlusion 29.8 CCL2 MTHFR SERPINF1 VEGFA
12 heart disease 29.7 ALB ICAM1 INS MTHFR VEGFA
13 retinal detachment 29.7 FZD4 LRP5 NDP SERPINF1 TSPAN12 VEGFA
14 corneal neovascularization 29.7 KDR PLG SERPINF1 VEGFA
15 macular holes 29.7 CCL2 SERPINF1 VEGFA
16 chronic kidney failure 29.5 ALB ICAM1 INS MTHFR
17 norrie disease 29.5 FZD4 LRP5 NDP TSPAN12
18 microvascular complications of diabetes 5 29.4 AKR1B1 ALB ICAM1 INS KDR PGF
19 macular degeneration, age-related, 1 29.4 CCL2 KDR PGF PLG SERPINF1 VEGFA
20 microvascular complications of diabetes 1 29.3 AKR1B1 CCL2 CCN2 ICAM1 INS SERPINF1
21 kidney disease 29.3 AKR1B1 ALB CCL2 CCN2 INS
22 arteries, anomalies of 29.1 ALB CCL2 ICAM1 INS PGF PLG
23 retinal degeneration 11.1
24 leukoencephalopathy, brain calcifications, and cysts 10.9
25 hemangioendothelioma 10.3 KDR PLG
26 hemifacial spasm 10.3 MTHFR VEGFA
27 diabetic cataract 10.3 AKR1B1 SERPINF1 VEGFA
28 lymphangioma 10.2 KDR SERPINF1 VEGFA
29 angiokeratoma circumscriptum 10.2 KDR VEGFA
30 diabetes mellitus 10.2
31 severe nonproliferative diabetic retinopathy 10.2 ALB INS VEGFA
32 endophthalmitis 10.2 ICAM1 PLG VEGFA
33 background diabetic retinopathy 10.2 ALB INS VEGFA
34 heterophyiasis 10.2 ALB ICAM1
35 hepatic vascular disease 10.2 ALB MTHFR PLG
36 pulmonary artery disease 10.2 ALB MTHFR PLG
37 persistent hyperplastic primary vitreous 10.2 FZD4 NDP TSPAN12
38 diabetic neuropathy 10.2 AKR1B1 INS VEGFA
39 carpal tunnel syndrome 10.2 INS PSMD9 VEGFA
40 ovarian hyperstimulation syndrome 10.2 ALB KDR VEGFA
41 vitreous disease 10.2 CCL2 PLG VEGFA
42 hypoglycemic coma 10.2 INS VEGFA
43 leukocoria 10.2 FZD4 LRP5 NDP
44 vitreous detachment 10.2 PLG VEGFA
45 vein disease 10.2 ALB MTHFR PLG VEGFA
46 retinal telangiectasia 10.2 FZD4 NDP TSPAN12 VEGFA
47 degeneration of macula and posterior pole 10.2 CCL2 KDR VEGFA
48 epithelioid hemangioendothelioma 10.2 KDR PGF VEGFA
49 osteoporosis-pseudoglioma syndrome 10.2 FZD4 LRP5 NDP
50 autonomic neuropathy 10.2 AKR1B1 ALB INS

Graphical network of the top 20 diseases related to Retinal Vascular Disease:



Diseases related to Retinal Vascular Disease

Symptoms & Phenotypes for Retinal Vascular Disease

UMLS symptoms related to Retinal Vascular Disease:


chest pain

MGI Mouse Phenotypes related to Retinal Vascular Disease:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 CCN2 FZD4 ICAM1 INS KDR LRP5
2 homeostasis/metabolism MP:0005376 10.22 AKR1B1 ALB CCN2 FZD4 ICAM1 INS
3 growth/size/body region MP:0005378 10.21 AKR1B1 CCN2 FZD4 ICAM1 INS KDR
4 endocrine/exocrine gland MP:0005379 10.16 ALB CCN2 FZD4 ICAM1 INS LRP5
5 digestive/alimentary MP:0005381 10.13 ALB CCN2 FZD4 ICAM1 INS OCLN
6 immune system MP:0005387 10.11 CCL2 ICAM1 INS KDR LRP5 OCLN
7 integument MP:0010771 9.97 CCN2 FZD4 ICAM1 INS KDR MTHFR
8 nervous system MP:0003631 9.93 AIPL1 FZD4 ICAM1 INS KDR LRP5
9 liver/biliary system MP:0005370 9.86 ALB CCN2 INS KDR LRP5 MTHFR
10 skeleton MP:0005390 9.65 AKR1B1 CCN2 INS KDR LRP5 MTHFR
11 vision/eye MP:0005391 9.5 AIPL1 AKR1B1 CCN2 FZD4 ICAM1 INS

Drugs & Therapeutics for Retinal Vascular Disease

Drugs for Retinal Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2
Ranibizumab Approved Phase 3 347396-82-1 459903
3 Angiogenesis Inhibitors Phase 3
4 Angiogenesis Modulating Agents Phase 3
5 Immunologic Factors Phase 3,Not Applicable
6 Endothelial Growth Factors Phase 3
7 Mitogens Phase 3
8
Regadenoson Approved, Investigational Phase 2 313348-27-5 219024
9
Adenosine Approved, Investigational Phase 2 58-61-7 60961
10 Neurotransmitter Agents Phase 2
11
Dipivefrin Approved Not Applicable 52365-63-6 3105
12
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
13 Hormones Not Applicable
14 Anesthetics Not Applicable
15 Immunosuppressive Agents Not Applicable
16 Proxymetacaine Not Applicable
17 Triamcinolone hexacetonide Not Applicable
18 Anti-Inflammatory Agents Not Applicable
19 Hormone Antagonists Not Applicable
20 Triamcinolone diacetate Not Applicable
21 triamcinolone acetonide Not Applicable
22 glucocorticoids Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
24 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion Completed NCT02033031 Phase 3 Lucentis intravitreal injection;Avastin intravitreal injection
2 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2 Regadenoson
3 Study to Assess the Safety and Tolerability of a Single Administration of FOV2302 (Ecallantide) in Patients With Macular Edema Associated With Central Retinal Vein Occlusion Terminated NCT00969293 Phase 1 FOV2302 (Ecallantide)
4 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619 Not Applicable
5 Sheathotomy vs. Intravitreal Triamcinolone for Branch Retinal Vein Occlusion Completed NCT00612261 Not Applicable
6 Morphologic Changes After Membrane Peeling With Air Tamponade and Balanced Salt Solution Completed NCT02319655 Not Applicable
7 Identifying Progression of Retinal Disease in Eyes With NPDR in Diabetes Type 2 Using Non-invasive Procedures Completed NCT01145599
8 Characterization of Retinal Vascular Disease in Eyes With Mild to Moderate NPDR in Diabetes Type 2 Recruiting NCT03696810 Not Applicable
9 Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics Recruiting NCT01994174
10 Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging Terminated NCT01834196 Not Applicable

Search NIH Clinical Center for Retinal Vascular Disease

Genetic Tests for Retinal Vascular Disease

Anatomical Context for Retinal Vascular Disease

MalaCards organs/tissues related to Retinal Vascular Disease:

41
Endothelial, Eye, Retina, Bone, Heart, Bone Marrow, Kidney

Publications for Retinal Vascular Disease

Articles related to Retinal Vascular Disease:

(show top 50) (show all 837)
# Title Authors Year
1
Retinal vascular density in multiple sclerosis: a 1-year follow-up. ( 30102834 )
2019
2
Retinal Vascular Geometry and the Prevalence of Atrial Fibrillation and Heart Failure in a Clinic-Based Sample. ( 30224171 )
2018
3
Non-Occlusive Retinal Vascular Inflammation and Role of Red Blood Cell Deformability in Birdshot Chorioretinopathy. ( 29985708 )
2018
4
Retinal Vascular Reactivity in Central Serous Chorioretinopathy. ( 30193313 )
2018
5
Associations of cytokine concentrations in aqueous humour with retinal vascular abnormalities and exudation in Coats' disease. ( 30414256 )
2018
6
Therapeutic Effects of a Novel Phenylphthalimide Analog for Corneal Neovascularization and Retinal Vascular Leakage. ( 30029250 )
2018
7
Relationship between aqueous humor cytokine level changes and retinal vascular changes after intravitreal aflibercept for diabetic macular edema. ( 30410092 )
2018
8
Retinal Vascular Caliber Changes After Topical Nepafenac Treatment for Diabetic Macular Edema. ( 29120250 )
2018
9
Attenuation of Retinal Vascular Development in Neonatal Mice Subjected to Hypoxic-Ischemic Encephalopathy. ( 29907863 )
2018
10
Paracentral Acute Middle Maculopathy and the Ischemic Cascade Associated With Retinal Vascular Occlusion. ( 30081014 )
2018
11
Retinal Vascular Degeneration in the Transgenic P23H Rat Model of Retinitis Pigmentosa. ( 30008665 )
2018
12
THE THICKNESSES OF CHOROID, MACULAR SEGMENTS, PERIPAPILLARY RETINAL NERVE FIBER LAYER, AND RETINAL VASCULAR CALIBER IN HIV-1-INFECTED PATIENTS WITHOUT INFECTIOUS RETINITIS. ( 29528981 )
2018
13
RETINAL VASCULAR ABNORMALITIES IN A LARGE COHORT OF PATIENTS AFFECTED BY NEUROFIBROMATOSIS TYPE 1: A Study Using Optical Coherence Tomography Angiography. ( 28248826 )
2018
14
Spectral-Domain OCT Findings of Retinal Vascular-Avascular Junction in Infants with Retinopathy of Prematurity. ( 30506013 )
2018
15
Retinal neuronal cell loss prevents abnormal retinal vascular growth in a rat model of retinopathy of prematurity. ( 29339088 )
2018
16
Retinal vascular speed <0.5 disc diameter per week as an early sign of retinopathy of prematurity requiring treatment. ( 29587487 )
2018
17
Retinal vascular flow and choroidal thickness in eyes with early age-related macular degeneration with reticular pseudodrusen. ( 30055588 )
2018
18
Reversal of Retinal Vascular Leakage and Arrest of Progressive Retinal Nonperfusion With Monthly Anti-Vascular Endothelial Growth Factor Therapy for Proliferative Diabetic Retinopathy. ( 30005003 )
2018
19
Temporal changes in retinal vascular parameters associated with successful panretinal photocoagulation in proliferative diabetic retinopathy: A prospective clinical interventional study. ( 29193789 )
2018
20
Inhibition of Diabetes-Induced Lysyl Oxidase Overexpression Prevents Retinal Vascular Lesions Associated With Diabetic Retinopathy. ( 30550614 )
2018
21
Effects of microRNA-133b on retinal vascular endothelial cell proliferation and apoptosis through angiotensinogen-mediated angiotensin II- extracellular signal-regulated kinase 1/2 signalling pathway in rats with diabetic retinopathy. ( 29488353 )
2018
22
The relationship of dietary fish intake to diabetic retinopathy and retinal vascular caliber in patients with type 2 diabetes. ( 29335432 )
2018
23
An automated framework to quantify areas of regional ischemia in retinal vascular diseases with OCT angiography. ( 28700136 )
2018
24
Retinal Vascular Diseases in the Asia-Pacific: Shifting Paradigms for Management. ( 29473347 )
2018
25
Evaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseases. ( 29969324 )
2018
26
Targeting myeloid cells in ischemic retinal vascular diseases. ( 30132279 )
2018
27
The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases. ( 30385175 )
2018
28
Epidemiology and clinical features of inflammatory retinal vascular occlusions: pooled data from two tertiary-referral institutions. ( 28557287 )
2018
29
Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis. ( 28933233 )
2018
30
Retinal vascular resistance in arterial hypertension. ( 29057671 )
2018
31
Retinal vascular imaging in cardiovascular medicine: New tools for an old examination. ( 29145994 )
2018
32
The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability. ( 29158262 )
2018
33
Photoreceptor glucose metabolism determines normal retinal vascular growth. ( 29180355 )
2018
34
Associations with retinal vascular occlusions in a diverse, urban population. ( 29190171 )
2018
35
Retinal vascular complications associated with interferon-ribavirin therapy for chronic hepatitis C: A population-based study. ( 29210149 )
2018
36
Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis. ( 29303033 )
2018
37
ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability. ( 29362226 )
2018
38
Retinal vascular alterations in reticular pseudodrusen with and without outer retinal atrophy assessed by optical coherence tomography angiography. ( 29363531 )
2018
39
Comparison of retinal vascular geometry in obese and non-obese children. ( 29389952 )
2018
40
The Adolescent Cardio-Renal Intervention Trial (AdDIT): retinal vascular geometry and renal function in adolescents with type 1 diabetes. ( 29396691 )
2018
41
Precise Measurement of Retinal Vascular Bed Area and Density on Ultra-wide Fluorescein Angiography in Normal Subjects. ( 29428456 )
2018
42
Fluorescein Labeled Leukocytes for in vivo Imaging of Retinal Vascular Inflammation and Infiltrating Leukocytes in Laser-Induced Choroidal Neovascularization Model. ( 29470933 )
2018
43
Long-term changes in retinal vascular diameter and cognitive impairment in type 1 diabetes. ( 29488397 )
2018
44
Analysis of Retinal Vascular Plexuses and Interplexus Connections. ( 29564799 )
2018
45
Optical coherence tomography angiography detects retinal vascular alterations in different phases of multiple sclerosis. ( 29587576 )
2018
46
Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936. ( 29600120 )
2018
47
Association between the retinal vascular network with Singapore "I" Vessel Assessment (SIVA) software, cardiovascular history and risk factors in the elderly: The Montrachet study, population-based study. ( 29614075 )
2018
48
Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner. ( 29615467 )
2018
49
Correction: Diabetes-related changes in the protein composition and the biomechanical properties of human retinal vascular basement membranes. ( 29624597 )
2018
50
Retinal vascular diameters in relation to physical activity in Danish children - The CHAMPS Eye Study. ( 29701884 )
2018

Variations for Retinal Vascular Disease

Expression for Retinal Vascular Disease

Search GEO for disease gene expression data for Retinal Vascular Disease.

Pathways for Retinal Vascular Disease

Pathways related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 CCL2 ICAM1 KDR OCLN VEGFA
2
Show member pathways
12.3 FZD4 INS KDR LRP5
3
Show member pathways
12.17 CCL2 ICAM1 KDR VEGFA
4
Show member pathways
11.81 CCL2 CCN2 ICAM1 KDR PGF
5 11.7 CCL2 ICAM1 VEGFA
6 11.7 CCL2 ICAM1 KDR VEGFA
7
Show member pathways
11.65 KDR PGF VEGFA
8 11.63 CCL2 ICAM1 VEGFA
9 11.58 ALB INS KDR VEGFA
10
Show member pathways
11.43 ALB CCL2 ICAM1 INS MTHFR PLG
11 11.3 KDR PLG VEGFA
12 11.23 CCN2 ICAM1 PLG
13
Show member pathways
11.12 INS KDR VEGFA
14 10.75 CCL2 ICAM1
15
Show member pathways
10.34 KDR PGF VEGFA

GO Terms for Retinal Vascular Disease

Cellular components related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ALB CCL2 CCN2 INS KDR NDP
2 collagen-containing extracellular matrix GO:0062023 9.56 ICAM1 NDP PLG SERPINF1
3 extracellular space GO:0005615 9.36 AKR1B1 ALB CCL2 CCN2 ICAM1 INS
4 platelet alpha granule lumen GO:0031093 9.33 ALB PLG VEGFA

Biological processes related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.9 CCN2 KDR SERPINF1 VEGFA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 CCL2 CCN2 ICAM1 KDR
3 Wnt signaling pathway GO:0016055 9.86 FZD4 LRP5 NDP TSPAN12
4 positive regulation of cell proliferation GO:0008284 9.85 CCN2 INS KDR LRP5 PGF VEGFA
5 positive regulation of protein phosphorylation GO:0001934 9.83 CCN2 KDR PGF VEGFA
6 response to hypoxia GO:0001666 9.76 ICAM1 MTHFR PGF VEGFA
7 canonical Wnt signaling pathway GO:0060070 9.75 FZD4 LRP5 NDP
8 positive regulation of endothelial cell proliferation GO:0001938 9.74 KDR PGF VEGFA
9 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 KDR PGF VEGFA
10 vasculogenesis GO:0001570 9.71 FZD4 KDR VEGFA
11 regulation of cell shape GO:0008360 9.71 CCL2 ICAM1 KDR VEGFA
12 regulation of signaling receptor activity GO:0010469 9.63 CCL2 CCN2 INS NDP PGF VEGFA
13 negative regulation of cell-substrate adhesion GO:0010812 9.62 FZD4 PLG
14 induction of positive chemotaxis GO:0050930 9.61 PGF VEGFA
15 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.61 CCL2 KDR
16 positive regulation of positive chemotaxis GO:0050927 9.59 KDR VEGFA
17 positive regulation of mast cell chemotaxis GO:0060754 9.51 PGF VEGFA
18 response to amino acid GO:0043200 9.5 CCN2 ICAM1 MTHFR
19 retina vasculature morphogenesis in camera-type eye GO:0061299 9.49 FZD4 NDP
20 retinal blood vessel morphogenesis GO:0061304 9.48 FZD4 LRP5
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.43 KDR VEGFA
22 extracellular matrix-cell signaling GO:0035426 9.26 FZD4 NDP
23 vascular endothelial growth factor signaling pathway GO:0038084 9.13 KDR PGF VEGFA
24 angiogenesis GO:0001525 9.1 CCL2 CCN2 KDR PGF TSPAN12 VEGFA
25 negative regulation of apoptotic process GO:0043066 10.02 AIPL1 AKR1B1 ALB KDR VEGFA

Molecular functions related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 AIPL1 ALB CCL2 CCN2 FZD4 ICAM1
2 growth factor activity GO:0008083 9.56 CCN2 NDP PGF VEGFA
3 vascular endothelial growth factor receptor 3 binding GO:0043185 9.16 PGF VEGFA
4 Wnt-activated receptor activity GO:0042813 8.8 FZD4 LRP5 TSPAN12

Sources for Retinal Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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