MCID: RTN020
MIFTS: 46

Retinal Vascular Disease

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Retinal Vascular Disease

MalaCards integrated aliases for Retinal Vascular Disease:

Name: Retinal Vascular Disease 12 15
Retinal Vascular 55 73
Retina Circulation Disorder 12
Retinal Vascular Disorder 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2462
NCIt 50 C35170
SNOMED-CT 68 57534004

Summaries for Retinal Vascular Disease

MalaCards based summary : Retinal Vascular Disease, also known as retinal vascular, is related to retinal vascular occlusion and exudative vitreoretinopathy, and has symptoms including chest pain An important gene associated with Retinal Vascular Disease is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Folate Metabolism. The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Retinal Vascular Disease

Diseases related to Retinal Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 retinal vascular occlusion 34.7 MTHFR PLG VEGFA
2 exudative vitreoretinopathy 30.9 FZD4 LRP5 NDP TSPAN12 ZNF408
3 vascular disease 30.6 ALB ICAM1 INS MTHFR PLG VEGFA
4 retinal vein occlusion 30.5 MTHFR SERPINF1 VEGFA
5 microvascular complications of diabetes 5 28.1 AKR1B1 ALB FLT1 ICAM1 INS KDR
6 retinal degeneration 11.0
7 diabetic cataract 10.8 AKR1B1 SERPINF1 VEGFA
8 central retinal vein occlusion 10.8 MTHFR SERPINF1 VEGFA
9 hemifacial spasm 10.8 MTHFR VEGFA
10 lymphangioma 10.8 KDR SERPINF1 VEGFA
11 vitreous disease 10.7 CTGF PLG VEGFA
12 degeneration of macula and posterior pole 10.7 KDR PLG VEGFA
13 macular retinal edema 10.7 ICAM1 SERPINF1 VEGFA
14 leukostasis 10.7 ICAM1 KDR VEGFA
15 rubeosis iridis 10.7 INS PLG VEGFA
16 endophthalmitis 10.7 ICAM1 PLG VEGFA
17 severe nonproliferative diabetic retinopathy 10.7 ALB INS VEGFA
18 background diabetic retinopathy 10.6 ALB INS VEGFA
19 hepatic vascular disease 10.6 ALB MTHFR PLG
20 persistent hyperplastic primary vitreous 10.6 FZD4 NDP TSPAN12
21 diabetic macular edema 10.6 ICAM1 SERPINF1 VEGFA
22 vein disease 10.6 ALB MTHFR PLG
23 carpal tunnel syndrome 10.6 CTGF PSMD9 VEGFA
24 hypoglycemic coma 10.6 INS VEGFA
25 ovarian hyperstimulation syndrome 10.6 ALB KDR VEGFA
26 diabetic neuropathy 10.6 AKR1B1 INS VEGFA
27 leukocoria 10.6 FZD4 LRP5 NDP
28 osteoporosis-pseudoglioma syndrome 10.5 FZD4 LRP5 NDP
29 retinal telangiectasia 10.5 FZD4 NDP TSPAN12 VEGFA
30 retinitis 10.5
31 vitreous detachment 10.5 PLG VEGFA
32 angiokeratoma circumscriptum 10.5 FLT1 KDR VEGFA
33 autonomic neuropathy 10.5 AKR1B1 ALB INS
34 epithelioid hemangioendothelioma 10.5 FLT1 KDR VEGFA
35 idiopathic interstitial pneumonia 10.5 CTGF ICAM1 VEGFA
36 sleep apnea 10.5 ICAM1 INS VEGFA
37 glucose metabolism disease 10.4 ALB INS PSMD9
38 vascular cancer 10.4 FLT1 KDR VEGFA
39 microvascular complications of diabetes 3 10.4 AKR1B1 ALB CTGF INS
40 placental insufficiency 10.4 FLT1 KDR VEGFA
41 angiosarcoma 10.3 FLT1 KDR VEGFA
42 hemangioendothelioma 10.3 KDR PLG
43 sialolithiasis 10.3 ALB CTGF LRP5
44 urinary system disease 10.3 ALB CTGF INS
45 acquired metabolic disease 10.3 ALB INS PSMD9
46 glomeruloid hemangioma 10.3 FLT1 VEGFA
47 norrie disease 10.3 FZD4 LRP5 NDP TSPAN12
48 eclampsia 10.2 ALB FLT1 MTHFR
49 acute hemorrhagic leukoencephalitis 10.1 FLT1 KDR OCLN VEGFA
50 breast carcinoma in situ 10.1 FLT1 KDR LIF VEGFA

Graphical network of the top 20 diseases related to Retinal Vascular Disease:



Diseases related to Retinal Vascular Disease

Symptoms & Phenotypes for Retinal Vascular Disease

UMLS symptoms related to Retinal Vascular Disease:


chest pain

MGI Mouse Phenotypes related to Retinal Vascular Disease:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.39 NDP LRP5 PLG SERPINF1 TSPAN12 VEGFA
2 growth/size/body region MP:0005378 10.34 MTHFR OCLN LRP5 PLG VEGFA FLT1
3 homeostasis/metabolism MP:0005376 10.34 MTHFR OCLN LRP5 PLG VEGFA FLT1
4 cellular MP:0005384 10.31 PLG LIF LRP5 VEGFA FLT1 ALB
5 endocrine/exocrine gland MP:0005379 10.28 OCLN LRP5 PLG SERPINF1 VEGFA ALB
6 digestive/alimentary MP:0005381 10.26 OCLN PLG SERPINF1 VEGFA ALB FZD4
7 immune system MP:0005387 10.22 PLG LIF OCLN LRP5 VEGFA ZNF408
8 mortality/aging MP:0010768 10.22 PLG MTHFR LIF LRP5 VEGFA AKR1B1
9 hematopoietic system MP:0005397 10.21 PLG LIF LRP5 VEGFA ZNF408 SERPINF1
10 nervous system MP:0003631 10.17 MTHFR NDP OCLN LRP5 PLG SERPINF1
11 embryo MP:0005380 10.15 LIF LRP5 VEGFA FLT1 FZD4 CTGF
12 integument MP:0010771 10.11 PLG MTHFR LIF VEGFA FZD4 CTGF
13 liver/biliary system MP:0005370 10.03 PLG LRP5 VEGFA ALB CTGF INS
14 muscle MP:0005369 10.02 OCLN VEGFA FLT1 ALB FZD4 LIF
15 normal MP:0002873 9.86 LRP5 VEGFA CTGF FLT1 ALB FZD4
16 reproductive system MP:0005389 9.85 PLG MTHFR NDP OCLN SERPINF1 VEGFA
17 skeleton MP:0005390 9.7 MTHFR NDP OCLN LRP5 SERPINF1 VEGFA
18 vision/eye MP:0005391 9.53 NDP LRP5 PLG MTHFR SERPINF1 TSPAN12

Drugs & Therapeutics for Retinal Vascular Disease

Drugs for Retinal Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2
Ranibizumab Approved Phase 3 347396-82-1 459903
3 Angiogenesis Inhibitors Phase 3
4 Angiogenesis Modulating Agents Phase 3
5 Endothelial Growth Factors Phase 3
6 Mitogens Phase 3
7
Adenosine Approved, Investigational Phase 2 58-61-7 60961
8
Regadenoson Approved, Investigational Phase 2 313348-27-5 219024
9 Neurotransmitter Agents Phase 2
10
Dipivefrin Approved Not Applicable 52365-63-6 3105
11
Triamcinolone Approved, Vet_approved Not Applicable 124-94-7 31307
12 Anesthetics Not Applicable
13 Anti-Inflammatory Agents Not Applicable
14 glucocorticoids Not Applicable
15 Hormone Antagonists Not Applicable
16 Hormones Not Applicable
17 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
18 Immunosuppressive Agents Not Applicable
19 Proxymetacaine Not Applicable
20 triamcinolone acetonide Not Applicable
21 Triamcinolone diacetate Not Applicable
22 Triamcinolone hexacetonide Not Applicable
23 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion Not yet recruiting NCT03405376 Phase 4 Intravitreal aflibercept injection
2 Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion Completed NCT02033031 Phase 3 Lucentis intravitreal injection;Avastin intravitreal injection
3 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2 Regadenoson
4 Study to Assess the Safety and Tolerability of a Single Administration of FOV2302 (Ecallantide) in Patients With Macular Edema Associated With Central Retinal Vein Occlusion Terminated NCT00969293 Phase 1 FOV2302 (Ecallantide)
5 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619 Not Applicable
6 Sheathotomy vs. Intravitreal Triamcinolone for Branch Retinal Vein Occlusion Completed NCT00612261 Not Applicable
7 Morphologic Changes After Membrane Peeling With Air Tamponade and Balanced Salt Solution Completed NCT02319655 Not Applicable
8 Identifying Progression of Retinal Disease in Eyes With NPDR in Diabetes Type 2 Using Non-invasive Procedures Completed NCT01145599
9 Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics Recruiting NCT01994174
10 Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging Terminated NCT01834196 Not Applicable

Search NIH Clinical Center for Retinal Vascular Disease

Genetic Tests for Retinal Vascular Disease

Anatomical Context for Retinal Vascular Disease

MalaCards organs/tissues related to Retinal Vascular Disease:

41
Retina, Eye, Endothelial

Publications for Retinal Vascular Disease

Articles related to Retinal Vascular Disease:

(show top 50) (show all 65)
# Title Authors Year
1
Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease. ( 28384676 )
2017
2
Ischemic Retinal Vascular Disease in an Infant With Hemophagocytic Lymphohistiocytosis. ( 28983568 )
2017
3
Do photoreceptor cells cause the development of retinal vascular disease? ( 28438678 )
2017
4
TESTOSTERONE SUPPLEMENTATION AND RETINAL VASCULAR DISEASE. ( 29040227 )
2017
5
Cell Therapy Applications for Retinal Vascular Diseases: Diabetic Retinopathy and Retinal Vein Occlusion. ( 27116667 )
2016
6
Adult lead exposure increases blood-retinal permeability: A risk factor for retinal vascular disease. ( 27663850 )
2016
7
Nanoengineering of therapeutics for retinal vascular disease. ( 26022642 )
2015
8
Systemic atheromatosis influence on retinal vascular disease. ( 25729610 )
2014
9
Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease. ( 23355773 )
2013
10
[Cytokine determination from vitreous samples in retinal vascular diseases]. ( 23224211 )
2013
11
Regional morphology and pathophysiology of retinal vascular disease. ( 23892140 )
2013
12
Macular ischaemia: a contraindication for anti-VEGF treatment in retinal vascular disease? ( 22250209 )
2012
13
The role of glia in retinal vascular disease. ( 22519424 )
2012
14
Retinal vascular disease and the pathogenesis of facioscapulohumeral muscular dystrophy. A signalling message from Wnt? ( 21377364 )
2011
15
The multifactorial nature of retinal vascular disease. ( 20714177 )
2010
16
[Aging and retinal vascular diseases]. ( 17402563 )
2007
17
Molecular targets for retinal vascular diseases. ( 17133346 )
2007
18
Newly recognized serous macular detachment in retinal vascular disease. ( 16770254 )
2006
19
Retinal vascular disease in hypertension. Risk factor modification optimizes vision outcomes. ( 16001767 )
2005
20
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia and occlusive retinal vascular disease in type 2 diabetic and non-diabetic subjects. ( 12356186 )
2002
21
Plasma total homocysteine and retinal vascular disease. ( 11040905 )
2000
22
Association of antiphospholipid antibodies with retinal vascular disease in systemic lupus erythematosus. ( 10342390 )
1999
23
Ambulatory blood pressure monitoring in cerebrovascular and retinal vascular disease. ( 17895027 )
1997
24
Ambulatory blood pressure monitoring in cerebrovascular and retinal vascular disease. ( 17895021 )
1997
25
Antiphospholipid antibodies and retinal vascular disease. ( 8869905 )
1996
26
On the significance of retinal vascular disease and hearing loss in facioscapulohumeral muscular dystrophy. ( 7739630 )
1995
27
On the significance of retinal vascular disease and hearing loss in facioscapulohumeral muscular dystrophy. ( 23573590 )
1995
28
Retinal vascular disease in ulcerative colitis. ( 8085600 )
1994
29
Arnall Patz Medal for Excellence in Retinal Vascular Disease. Matthew D. Davis, MD. ( 1439249 )
1992
30
Cerebral ischemic events associated with endocarditis, retinal vascular disease, and lupus anticoagulant. ( 1900660 )
1991
31
The patency of the retinal vasculature to erythrocytes in retinal vascular disease. ( 2318585 )
1990
32
Semiconductor diode laser photocoagulation in retinal vascular disease. ( 2255529 )
1990
33
Crohn's disease and retinal vascular disease. ( 2220968 )
1990
34
Antiphospholipid antibodies associated with retinal vascular disease. ( 2133045 )
1990
35
Initial clinical experience using a diode laser in the treatment of retinal vascular disease. ( 2630328 )
1989
36
Occlusive retinal vascular disease in two patients. ( 2788911 )
1989
37
The tunable dye laser in the management of retinal vascular disease. ( 3229908 )
1988
38
Antiphospholipid antibodies associated with retinal vascular disease. ( 3124231 )
1987
39
The eyes of Woodrow Wilson. Retinal vascular disease and George de Schweinitz. ( 3887267 )
1985
40
Occlusive retinal vascular disease in systemic lupus erythematosus. ( 6084063 )
1984
41
Treatment of retinal vascular disease using photocoagulation and cryotherapy. ( 6676223 )
1983
42
Digital subtraction angiography in the diagnosis of retinal vascular disease. ( 6195923 )
1983
43
Selected molecular weight dextrans for in vivo permeability studies of rat retinal vascular disease. ( 872904 )
1977
44
Photocoagulation in retinal vascular disease. ( 281780 )
1977
45
Retinal vascular disease: introduction and phenomenology. ( 888253 )
1977
46
Clinical understanding in the management of retinal vascular disease. ( 1070871 )
1976
47
Symposium on retinal vascular disease. Conclusion. ( 1070875 )
1976
48
Occlusive retinal vascular disease and deafness. ( 949074 )
1976
49
Retinal vascular disease. ( 4415614 )
1974
50
Evolution of hypertensive retinal vascular disease: correlation between clinical and postmortem observations. ( 4748590 )
1973

Variations for Retinal Vascular Disease

Expression for Retinal Vascular Disease

Search GEO for disease gene expression data for Retinal Vascular Disease.

Pathways for Retinal Vascular Disease

GO Terms for Retinal Vascular Disease

Cellular components related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ALB CTGF FLT1 INS KDR LIF
2 extracellular space GO:0005615 9.36 AKR1B1 ALB CTGF FLT1 ICAM1 INS
3 platelet alpha granule lumen GO:0031093 9.33 ALB PLG VEGFA

Biological processes related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 CTGF INS LIF NDP VEGFA
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.9 CTGF FLT1 ICAM1 KDR
3 negative regulation of gene expression GO:0010629 9.88 CTGF KDR SERPINF1 VEGFA
4 negative regulation of apoptotic process GO:0043066 9.87 AIPL1 AKR1B1 ALB FLT1 INS KDR
5 positive regulation of cell migration GO:0030335 9.84 FLT1 INS KDR VEGFA
6 positive regulation of MAPK cascade GO:0043410 9.8 FLT1 INS KDR LIF
7 angiogenesis GO:0001525 9.8 CTGF FLT1 KDR TSPAN12 VEGFA
8 lung development GO:0030324 9.79 CTGF LIF VEGFA
9 canonical Wnt signaling pathway GO:0060070 9.79 FZD4 LRP5 NDP
10 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.74 FLT1 KDR VEGFA
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.73 FLT1 INS KDR
12 positive regulation of cell proliferation GO:0008284 9.7 CTGF FLT1 INS KDR LIF LRP5
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 ICAM1 INS LIF VEGFA
14 negative regulation of cell-substrate adhesion GO:0010812 9.63 FZD4 PLG
15 response to amino acid GO:0043200 9.63 CTGF ICAM1 MTHFR
16 cell migration involved in sprouting angiogenesis GO:0002042 9.62 KDR VEGFA
17 positive regulation of positive chemotaxis GO:0050927 9.61 KDR VEGFA
18 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.61 FLT1 KDR VEGFA
19 vascular endothelial growth factor signaling pathway GO:0038084 9.59 FLT1 KDR
20 vasculogenesis GO:0001570 9.56 FLT1 FZD4 KDR VEGFA
21 regulation of cGMP metabolic process GO:0030823 9.52 AIPL1 VEGFA
22 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.51 KDR VEGFA
23 retinal blood vessel morphogenesis GO:0061304 9.48 FZD4 LRP5
24 retina vasculature morphogenesis in camera-type eye GO:0061299 9.13 FZD4 LRP5 NDP
25 extracellular matrix-cell signaling GO:0035426 8.8 FZD4 LRP5 NDP
26 multicellular organism development GO:0007275 10.13 FLT1 FZD4 KDR LIF LRP5 SERPINF1

Molecular functions related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 AIPL1 ALB CTGF FLT1 FZD4 ICAM1
2 growth factor activity GO:0008083 9.46 CTGF LIF NDP VEGFA
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 FLT1 KDR
4 Wnt-activated receptor activity GO:0042813 8.8 FZD4 LRP5 TSPAN12

Sources for Retinal Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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