MCID: RTN021
MIFTS: 45

Retinal Vascular Occlusion

Categories: Blood diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Vascular Occlusion

MalaCards integrated aliases for Retinal Vascular Occlusion:

Name: Retinal Vascular Occlusion 12 54 15 70
Retinal Vasc. Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1729
ICD9CM 34 362.3
NCIt 50 C34980
SNOMED-CT 67 267717005
ICD10 32 H34 H34.9
UMLS 70 C0035326

Summaries for Retinal Vascular Occlusion

MalaCards based summary : Retinal Vascular Occlusion, also known as retinal vasc. occlusion, is related to thrombophilia and central retinal vein occlusion, and has symptoms including amaurosis fugax An important gene associated with Retinal Vascular Occlusion is F5 (Coagulation Factor V), and among its related pathways/superpathways are TGF-Beta Pathway and Response to elevated platelet cytosolic Ca2+. The drug Bevacizumab has been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 73 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

Related Diseases for Retinal Vascular Occlusion

Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 562)
# Related Disease Score Top Affiliating Genes
1 thrombophilia 30.6 SERPINC1 SELP MTHFR F5 F2 APOH
2 central retinal vein occlusion 30.6 VEGFA SERPINC1 MTHFR IL6 F5 F2
3 amaurosis fugax 30.5 MTHFR F5
4 protein s deficiency 30.4 SERPINC1 MTHFR F5 F2 APOH
5 branch retinal artery occlusion 30.4 VEGFA SERPINC1 PLG MTHFR F2 CRYAA
6 arteritic anterior ischemic optic neuropathy 30.4 MTHFR F5 F2
7 thrombotic thrombocytopenic purpura 30.4 SERPINC1 SELP APOH
8 thrombophilia due to thrombin defect 30.3 SERPINC1 MTHFR F5 F2 APOH
9 thrombophilia due to activated protein c resistance 30.1 SERPINC1 PLG MTHFR F5 F2 APOH
10 carotid artery disease 30.1 SELP PLG CRP CCL2
11 antiphospholipid syndrome 30.1 SERPINC1 SELP MTHFR F5 F2 CRP
12 atrial fibrillation 30.1 VKORC1 SELP F2 CRP
13 open-angle glaucoma 30.0 VEGFA MTHFR IL6 EDN1 CRYAA
14 papilledema 30.0 VEGFA SERPINC1 F2 CRP APOH
15 vasculitis 29.9 SELP IL6 ICAM1 CRP CCL2 APOH
16 optic nerve disease 29.9 VEGFA IL6 EDN1 CRYAA CRP
17 homocysteinemia 29.9 SERPINC1 MTHFR F5 F2 CRP CCL2
18 antithrombin iii deficiency 29.9 SERPINC1 PLG MTHFR F5 F2 APOH
19 central retinal artery occlusion 29.9 VEGFA SERPINC1 PLG MTHFR F2 EDN1
20 purpura 29.9 SERPINC1 IL6 F2 CRP APOH
21 retinal detachment 29.9 VEGFA IL6 EDN1 CXCL8 CCL2
22 retinal vascular disease 29.8 VEGFB VEGFA PLG PGF MTHFR KDR
23 macular holes 29.7 VEGFA PLG IL6 CXCL8 CRYAA CCL2
24 carotid stenosis 29.6 VEGFA SELP MTHFR ICAM1 CXCL8 CRP
25 neovascular glaucoma 29.6 VEGFB VEGFA PLG PGF KDR FLT1
26 microvascular complications of diabetes 5 29.5 VEGFA PLG PGF KDR ICAM1 FLT1
27 eclampsia 29.4 VEGFA SERPINC1 PGF MTHFR FLT1 F2
28 retinal vein occlusion 29.4 VKORC1 VEGFA SERPINC1 MTHFR KDR IL6
29 cerebrovascular disease 29.4 VKORC1 SELP MTHFR IL6 ICAM1 F5
30 ischemia 29.3 VEGFA SELP PLG KDR ICAM1 FLT1
31 nonarteritic anterior ischemic optic neuropathy 29.3 VEGFA SERPINC1 MTHFR F5 F2 EDN1
32 patent foramen ovale 29.3 SERPINC1 PLG MTHFR F5 F2 EDN1
33 systemic lupus erythematosus 29.1 VEGFA SELP IL6 ICAM1 F2 CXCL8
34 macular retinal edema 28.9 VEGFB VEGFA PGF KDR IL6 ICAM1
35 vascular disease 28.8 VEGFA SERPINC1 SELP PLG MTHFR IL6
36 atherosclerosis susceptibility 28.7 VEGFA SELP MTHFR IL6 ICAM1 EDN1
37 placenta disease 28.7 VEGFA SERPINC1 PGF MTHFR IL6 FLT1
38 retinal artery occlusion 28.7 VEGFB VEGFA SERPINC1 PLG PGF MTHFR
39 eye disease 28.6 VEGFA PGF KDR IL6 ICAM1 FLT1
40 behcet syndrome 28.6 VEGFA SERPINC1 MTHFR IL6 ICAM1 F5
41 type 2 diabetes mellitus 27.8 VEGFA SERPINC1 SELP MTHFR KDR IL6
42 diabetes mellitus 27.7 VEGFA SERPINC1 SELP PGF MTHFR KDR
43 pre-eclampsia 27.6 VEGFA SERPINC1 SELP PGF MTHFR KDR
44 may-thurner syndrome 10.5 F5 APOH
45 acanthamoeba keratitis 10.5 F5 APOH
46 paracetamol poisoning 10.4 F5 F2
47 hemifacial spasm 10.4 VEGFA MTHFR
48 aspirin resistance 10.4 F5 F2
49 sticky platelet syndrome 10.4 SERPINC1 F5
50 bullous retinoschisis 10.4 VEGFA F5

Comorbidity relations with Retinal Vascular Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to Retinal Vascular Occlusion

Symptoms & Phenotypes for Retinal Vascular Occlusion

UMLS symptoms related to Retinal Vascular Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 APOH CRP EDN1 F2 F5 FLT1
2 cardiovascular system MP:0005385 10.35 CRP EDN1 F2 F5 FLT1 ICAM1
3 growth/size/body region MP:0005378 10.3 EDN1 F2 F5 FLT1 ICAM1 IL6
4 immune system MP:0005387 10.18 CCL2 CRP F2 FLT1 ICAM1 IL6
5 mortality/aging MP:0010768 10.13 APOH EDN1 F2 F5 FLT1 ICAM1
6 integument MP:0010771 10.11 F2 F5 ICAM1 IL6 KDR MTHFR
7 liver/biliary system MP:0005370 9.92 F5 IL6 KDR MTHFR PLG SELP
8 muscle MP:0005369 9.81 EDN1 F2 FLT1 ICAM1 IL6 KDR
9 nervous system MP:0003631 9.8 EDN1 F2 F5 FLT1 ICAM1 IL6
10 vision/eye MP:0005391 9.36 FLT1 ICAM1 IL6 KDR MTHFR PGF

Drugs & Therapeutics for Retinal Vascular Occlusion

Drugs for Retinal Vascular Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bevacizumab and Retinal Vascular Occlusions Unknown status NCT00347711 Phase 3 Intravitreal injection
2 Examination of the Body-fluid Balance in Patients With Retinal Vascular Occlusion Before and During Hemodilution and the Influence of Drinking Habits on the Degree of Body Hydration Unknown status NCT01939119
3 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862

Search NIH Clinical Center for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

Anatomical Context for Retinal Vascular Occlusion

MalaCards organs/tissues related to Retinal Vascular Occlusion:

40
Eye, Retina, Endothelial, Bone Marrow, Bone, Heart

Publications for Retinal Vascular Occlusion

Articles related to Retinal Vascular Occlusion:

(show top 50) (show all 285)
# Title Authors PMID Year
1
Behçet's disease: from Hippocrates to the third millennium. 54 61
12928293 2003
2
Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with Behçet's disease. 61 54
12881356 2003
3
Factor V Leiden and prothrombin gene G20210A mutations in ocular Behçet disease. 61 54
12780409 2003
4
[Thrombophilia factors as inducers of retinal vascular occlusion]. 54 61
11450475 2001
5
Peripheral retinal neovascularization and retinal vascular occlusion associated with activated protein C resistance. 61 54
9372725 1997
6
Antiphospholipid antibodies in retinal vascular occlusions. A prospective study of 75 patients. 61 54
8002838 1994
7
[Intraocular inflammation with brolucizumab use : Patient management-diagnosis-therapy]. 61
33555415 2021
8
Intravitreal anti-vascular endothelial growth factor medications during pregnancy: current perspective. 61
33044671 2021
9
The association of aldosterone with papillophlebitis and retinal artery occlusion: A case report. 61
33525896 2021
10
Association of Retinal Vascular Occlusion With Women Filling a Prescription for Female Hormone Therapy. 61
33180101 2021
11
Intravitreal anti-VEGF therapy is not associated with a higher risk of all-cause mortality in patients with macular oedema caused by posterior segment vascular diseases. 61
33389820 2021
12
Bilateral combined retinal vascular occlusion as a presenting feature in a case of systemic lupus erythematosus. 61
33521823 2021
13
Factors associated with ocular adverse event after immune checkpoint inhibitor treatment. 61
32556494 2020
14
Inherited and acquired thrombophilia in adults with retinal vascular occlusion: A systematic review and meta-analysis. 61
32805772 2020
15
Vancomycin-associated retinal hemorrhages in pediatric age group: A case report. 61
32913922 2020
16
Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER. 61
33207259 2020
17
Laquinimod exerts anti-inflammatory and antiapoptotic effects in retinal ischemia/reperfusion injury. 61
33182069 2020
18
Combined retinal vascular occlusion: Demography, clinical features, visual outcome, systemic co-morbidities, and literature review. 61
32971625 2020
19
[Combined retinal vascular occlusion after overexertion in sport at a young age : An unusual case as interdisciplinary challenge]. 61
32930866 2020
20
Cerebrospinal fluid leak from lateral orbit during exenteration for mucormycosis. 61
32928823 2020
21
Retinal ischemia triggers early microglia activation in the optic nerve followed by neurofilament degeneration. 61
32645332 2020
22
Isolated cilioretinal artery occlusion secondary to perinuclear antineutrophil cytoplasmic antibody vasculitis. 61
30947529 2020
23
OCT based interpretation of the optic nerve head anatomy in young adults with retinal vascular occlusions and ischemic optic neuropathy. 61
32907397 2020
24
Expert Opinion on Management of Intraocular Inflammation, Retinal Vasculitis, and Vascular Occlusion after Brolucizumab Treatment. 61
33007521 2020
25
[Vitreous body hemorrhage-How long can one wait?] 61
32385553 2020
26
Radiomics-based assessment of ultra-widefield leakage patterns and vessel network architecture in the PERMEATE study: insights into treatment durability. 61
32816791 2020
27
Acute Visual Loss Related to Retinal Vascular Occlusion Secondary to Visual Pathway Primary Glioblastoma. 61
32701755 2020
28
Human Adenovirus: An Unusual Causative Agent for Acute Retinal Necrosis Presented with Central Retinal Vascular Occlusion. 61
31411554 2020
29
Hyperreflective foci in diabetic macular edema with serous retinal detachment: association with dyslipidemia. 61
32114640 2020
30
Suspected Gentamicin-Induced Retinal Vascular Occlusion after Vitrectomy. 61
32999678 2020
31
[Indications for fluorescein angiography and optical coherence tomography angiography (OCTA) in medical retina: Changes from 2015 and 2018]. 61
32115267 2020
32
Efficacy and safety of non-vitamin K-antagonist oral anticoagulants for retinal vascular diseases in patients with atrial fibrillation: Korean cohort study. 61
32165726 2020
33
Risks of ophthalmic disorders in patients with systemic lupus erythematosus - a secondary cohort analysis of population-based claims data. 61
32160869 2020
34
Spectrum of Eye Disease in Diabetes (SPEED) in India: A prospective facility-based study. Report # 3. Retinal vascular occlusion in patients with type 2 diabetes mellitus. 61
31937725 2020
35
Spectrum of eye disorders in diabetes (SPEED) in India: Eye care facility based study. Report # 1. Eye disorders in people with type 2 diabetes mellitus. 61
31937723 2020
36
Moyamoya Disease Associated With Morning Glory Disc Anomaly and Other Ophthalmic Findings: A Mini-Review. 61
32499749 2020
37
Immune-Related Oral, Otologic, and Ocular Adverse Events. 61
32301024 2020
38
Applications of microneedles in delivering drugs for various ocular diseases. 61
31606378 2019
39
Complement Factor H Mutation W1206R Causes Retinal Thrombosis and Ischemic Retinopathy in Mice. 61
30711487 2019
40
Ocular toxicity of intravitreal melphalan for retinoblastoma in Chinese patients. 61
30808420 2019
41
Aspirin use in central retinal arterial occlusion to prevent ischaemic stroke: a retrospective cohort study in Taiwan. 61
30819710 2019
42
Development of a Novel Model of Central Retinal Vascular Occlusion and the Therapeutic Potential of the Adrenomedullin-Receptor Activity-Modifying Protein 2 System. 61
30658846 2019
43
A rare case having hemi-retinal artery occlusion in one eye and hemi-retinal vein occlusion in the other: Diverse manifestations of retinal vascular occlusion. 61
30672489 2019
44
Acute retinal toxicity associated with a mixture of perfluorooctane and perfluorohexyloctane: failure of another indirect cytotoxicity analysis. 61
29599249 2019
45
Insights into the pathogenesis of cystoid macular edema: leukostasis and related cytokines. 61
31341814 2019
46
Non-Occlusive Retinal Vascular Inflammation and Role of Red Blood Cell Deformability in Birdshot Chorioretinopathy. 61
29985708 2019
47
Combined central retinal vein, central retinal artery and cilioretinal artery occlusion with ischemic macular hole secondary to severe orbital cellulitis after black fly bite. 61
31118832 2019
48
Sudden unilateral vision loss in an adult with Behcet disease: A case report. 61
30558031 2018
49
Paracentral Acute Middle Maculopathy and the Ischemic Cascade Associated With Retinal Vascular Occlusion. 61
30081014 2018
50
A case report of branch retinal artery occlusion in a teenager due to hyperhomocysteinaemia; the interplay of genetic and nutritional defects. 61
30255822 2018

Variations for Retinal Vascular Occlusion

Expression for Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for Retinal Vascular Occlusion

Pathways related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

(show all 47)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 VEGFB VEGFA PGF KDR IL6 ICAM1
2
Show member pathways
13.3 VEGFB VEGFA SERPINC1 SELP PLG F5
3
Show member pathways
13.29 VEGFB PGF KDR IL6 FLT1 CXCL8
4
Show member pathways
13.03 VEGFB PGF KDR IL6 FLT1 F2
5
Show member pathways
12.98 VEGFB VEGFA PGF KDR IL6 FLT1
6
Show member pathways
12.81 PLG IL6 ICAM1 CXCL8 CCL2
7 12.79 VEGFB VEGFA PGF IL6 F2 EDN1
8 12.75 VEGFB VEGFA PGF KDR FLT1
9
Show member pathways
12.73 VEGFB VEGFA PGF KDR FLT1
10
Show member pathways
12.69 VEGFB PGF KDR IL6 FLT1
11
Show member pathways
12.42 VEGFB VEGFA PGF KDR FLT1
12
Show member pathways
12.38 VEGFA KDR ICAM1 CCL2
13
Show member pathways
12.38 VEGFB PGF KDR IL6 FLT1
14 12.37 VEGFB VEGFA KDR FLT1
15
Show member pathways
12.25 VEGFB PGF KDR IL6 FLT1 CXCL8
16
Show member pathways
12.16 SERPINC1 PLG F5 F2
17
Show member pathways
12.13 PLG MTHFR IL6 ICAM1 F2 CRP
18 12.12 SERPINC1 PLG F5 F2
19 12.05 VEGFA KDR ICAM1 EDN1 CCL2
20 11.98 IL6 ICAM1 EDN1 CCL2
21 11.97 VEGFA IL6 FLT1 EDN1
22 11.91 SELP IL6 ICAM1 CXCL8 CCL2
23 11.86 VEGFA IL6 ICAM1 CXCL8 CCL2
24 11.84 VEGFB KDR FLT1 CCL2
25 11.79 IL6 ICAM1 CXCL8
26
Show member pathways
11.73 VEGFB VEGFA PGF KDR FLT1
27
Show member pathways
11.66 VEGFA IL6 ICAM1 CXCL8
28 11.65 IL6 EDN1 CXCL8 CCL2
29 11.6 VEGFA IL6 ICAM1 FLT1 CXCL8 CCL2
30 11.58 VEGFB VEGFA EDN1
31 11.55 VEGFA IL6 CXCL8
32 11.53 VEGFA PLG KDR
33 11.49 IL6 ICAM1 CXCL8 CCL2
34 11.46 SELP PLG IL6 ICAM1
35 11.42 SELP IL6 ICAM1 CXCL8 CCL2
36 11.39 VEGFB VEGFA KDR FLT1
37 11.35 IL6 CXCL8 CCL2
38 11.35 VEGFA KDR FLT1
39
Show member pathways
11.29 VEGFA EDN1 CRP
40 11.21 VEGFA SERPINC1 FLT1
41 11.19 ICAM1 F2 CCL2
42 11.17 VEGFB VEGFA IL6 ICAM1 EDN1 CXCL8
43 11.15 VEGFA KDR FLT1
44 11.04 IL6 CXCL8 CRP
45 10.98 VEGFB PGF KDR IL6 FLT1 CXCL8
46 10.64 VEGFB VEGFA
47
Show member pathways
10.56 VEGFB VEGFA PGF KDR FLT1

GO Terms for Retinal Vascular Occlusion

Cellular components related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 VEGFB VEGFA SERPINC1 PLG PGF KDR
2 collagen-containing extracellular matrix GO:0062023 9.65 SERPINC1 PLG ICAM1 F2 APOH
3 extracellular space GO:0005615 9.53 VEGFB VEGFA SERPINC1 SELP PLG PGF
4 platelet alpha granule lumen GO:0031093 9.46 VEGFB VEGFA PLG F5

Biological processes related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.08 VEGFA PGF KDR IL6 FLT1 F2
2 inflammatory response GO:0006954 10.07 SELP IL6 CXCL8 CRP CCL2
3 negative regulation of gene expression GO:0010629 10.04 VEGFB VEGFA KDR EDN1 CXCL8
4 cytokine-mediated signaling pathway GO:0019221 10.03 VEGFA IL6 ICAM1 CXCL8 CCL2
5 cellular protein metabolic process GO:0044267 9.99 SERPINC1 PLG IL6 F5 F2
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 VEGFB VEGFA KDR ICAM1 CCL2
7 cellular response to lipopolysaccharide GO:0071222 9.97 IL6 ICAM1 CXCL8 CCL2
8 positive regulation of protein phosphorylation GO:0001934 9.97 VEGFB VEGFA PGF KDR F2
9 blood coagulation GO:0007596 9.96 VKORC1 SERPINC1 PLG F5 F2
10 cellular response to tumor necrosis factor GO:0071356 9.95 ICAM1 EDN1 CXCL8 CCL2
11 positive regulation of MAPK cascade GO:0043410 9.91 VEGFA KDR IL6 FLT1
12 regulation of cell shape GO:0008360 9.91 VEGFA KDR ICAM1 F2 CCL2
13 response to hypoxia GO:0001666 9.91 VEGFB VEGFA PGF MTHFR ICAM1 EDN1
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.9 VEGFB VEGFA IL6 ICAM1
15 cellular response to interleukin-1 GO:0071347 9.88 ICAM1 EDN1 CXCL8 CCL2
16 positive regulation of angiogenesis GO:0045766 9.88 VEGFB VEGFA PGF KDR FLT1 CXCL8
17 neutrophil chemotaxis GO:0030593 9.87 EDN1 CXCL8 CCL2
18 angiogenesis GO:0001525 9.87 VEGFB VEGFA PGF KDR FLT1 CXCL8
19 positive regulation of endothelial cell migration GO:0010595 9.86 VEGFA KDR EDN1
20 positive regulation of MAP kinase activity GO:0043406 9.85 VEGFA FLT1 EDN1
21 positive regulation of endothelial cell proliferation GO:0001938 9.85 VEGFB VEGFA PGF KDR
22 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 VEGFA SELP KDR FLT1 F2
23 positive regulation of cell division GO:0051781 9.83 VEGFB VEGFA PGF
24 positive chemotaxis GO:0050918 9.83 VEGFB VEGFA PGF
25 monocyte chemotaxis GO:0002548 9.83 IL6 FLT1 CCL2
26 hemostasis GO:0007599 9.83 SERPINC1 PLG F5 F2
27 acute-phase response GO:0006953 9.82 IL6 F2 CRP
28 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.81 VEGFA KDR FLT1
29 response to amino acid GO:0043200 9.8 MTHFR ICAM1 EDN1
30 sprouting angiogenesis GO:0002040 9.79 VEGFB VEGFA PGF
31 branching involved in blood vessel morphogenesis GO:0001569 9.78 VEGFA KDR EDN1
32 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.77 VEGFB VEGFA PGF KDR FLT1
33 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.69 VEGFA PLG
34 negative regulation of smooth muscle cell apoptotic process GO:0034392 9.69 EDN1 APOH
35 negative regulation of lipid storage GO:0010888 9.69 IL6 CRP
36 vascular wound healing GO:0061042 9.68 VEGFA KDR
37 acute inflammatory response to antigenic stimulus GO:0002438 9.68 SERPINC1 ICAM1
38 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.67 VEGFA KDR
39 negative regulation of fibrinolysis GO:0051918 9.67 PLG F2 APOH
40 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.66 VEGFA KDR
41 positive regulation of mast cell chemotaxis GO:0060754 9.65 VEGFB VEGFA PGF
42 platelet degranulation GO:0002576 9.63 VEGFB VEGFA SELP PLG F5 APOH
43 induction of positive chemotaxis GO:0050930 9.56 VEGFB VEGFA PGF CXCL8
44 regulation of blood coagulation GO:0030193 9.26 VKORC1 SERPINC1 F2 APOH
45 vascular endothelial growth factor signaling pathway GO:0038084 9.02 VEGFB VEGFA PGF KDR FLT1

Molecular functions related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.65 VEGFA IL6 EDN1 CXCL8 CCL2
2 growth factor activity GO:0008083 9.55 VEGFB VEGFA PGF IL6 F2
3 chemoattractant activity GO:0042056 9.54 VEGFB VEGFA PGF
4 vascular endothelial growth factor-activated receptor activity GO:0005021 9.4 KDR FLT1
5 vascular endothelial growth factor receptor 1 binding GO:0043183 9.32 VEGFB VEGFA
6 heparin binding GO:0008201 9.17 VEGFB VEGFA SERPINC1 SELP PGF F2
7 vascular endothelial growth factor receptor binding GO:0005172 9.13 VEGFB VEGFA PGF

Sources for Retinal Vascular Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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