MCID: RTN021
MIFTS: 43

Retinal Vascular Occlusion

Categories: Blood diseases, Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Vascular Occlusion

MalaCards integrated aliases for Retinal Vascular Occlusion:

Name: Retinal Vascular Occlusion 12 55 15 73
Retinal Vasc. Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1729
ICD10 33 H34 H34.9
ICD9CM 35 362.3 362.30
NCIt 50 C34980
SNOMED-CT 68 73757007
UMLS 73 C0035326

Summaries for Retinal Vascular Occlusion

MalaCards based summary : Retinal Vascular Occlusion, also known as retinal vasc. occlusion, is related to central retinal vein occlusion and central retinal artery occlusion, and has symptoms including amaurosis fugax An important gene associated with Retinal Vascular Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Bevacizumab and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 76 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

Related Diseases for Retinal Vascular Occlusion

Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 central retinal vein occlusion 30.8 VEGFA SERPINC1 MTHFR F5 F2 APOH
2 central retinal artery occlusion 30.7 FANCG PLG
3 retinal vascular disease 30.2 CCL2 MTHFR PGF PLG VEGFA
4 papilledema 29.9 APOH F2
5 thrombophilia 29.9 APOH F2 F5 MTHFR SERPINC1
6 catastrophic antiphospholipid syndrome 29.9 APOH F5 MTHFR
7 atrial fibrillation 29.7 F2 SELP VKORC1
8 retinal vasculitis 29.7 APOH CCL2
9 purpura 29.7 APOH F2 SERPINC1
10 ischemic optic neuropathy 29.7 F2 F5 MTHFR SERPINC1 APOH
11 antiphospholipid syndrome 29.5 SERPINC1 SELP MTHFR F5 F2 APOH
12 nonarteritic anterior ischemic optic neuropathy 29.5 F2 F5 MTHFR SERPINC1
13 macular retinal edema 29.4 CCL2 FANCG VEGFA
14 arteritic anterior ischemic optic neuropathy 29.4 F2 F5 FANCG MTHFR
15 branch retinal artery occlusion 29.2 SERPINC1 MTHFR FANCG F2 APOH
16 retinal artery occlusion 29.1 VEGFA SERPINC1 MTHFR F5 F2 APOH
17 retinal vein occlusion 28.9 VKORC1 VEGFA SERPINC1 MTHFR F5 F2
18 retinal disease 10.5
19 transient retinal arterial occlusion 10.4
20 may-thurner syndrome 10.2 APOH F5
21 acanthamoeba keratitis 10.2 APOH F5
22 pregnancy loss, recurrent 1 10.2 APOH F5
23 inferior vena cava interruption 10.2 F5 MTHFR
24 vitreous detachment 10.2 PLG VEGFA
25 amaurosis fugax 10.2 F5 MTHFR
26 hemifacial spasm 10.2 MTHFR VEGFA
27 chronic myocardial ischemia 10.2 PLG VEGFA
28 platelet aggregation, spontaneous 10.2 SELP SERPINC1
29 sticky platelet syndrome 10.2 F5 SERPINC1
30 carotid artery occlusion 10.2 APOH F5
31 blood group, globoside system 10.2 PLG VEGFA
32 qualitative platelet defect 10.2 F2 SELP
33 paracetamol poisoning 10.2 F2 F5
34 vitamin k deficiency hemorrhagic disease 10.1 F2 VKORC1
35 endophthalmitis 10.1 PLG VEGFA
36 hemoglobin e disease 10.1 F2 F5
37 lateral medullary syndrome 10.1 APOH PLG
38 mitral valve stenosis 10.1 SELP SERPINC1
39 cerebral falx meningioma 10.1 F2 PLG
40 factor viii deficiency 10.1 F2 F5
41 hemorrhagic fever 10.1 F2 SERPINC1
42 neovascular glaucoma 10.1 PGF VEGFA
43 femoral neuropathy 10.1 F2 PLG
44 mesenteric vascular occlusion 10.1 F2 MTHFR
45 meningococcemia 10.1 F5 SERPINC1
46 kuhnt-junius degeneration 10.1 PGF VEGFA
47 epithelioid hemangioendothelioma 10.1 PGF VEGFA
48 ischemic neuropathy 10.1 F2 MTHFR
49 cancer-associated retinopathy 10.1 PGF VEGFA
50 fournier gangrene 10.1 F2 SERPINC1

Comorbidity relations with Retinal Vascular Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to Retinal Vascular Occlusion

Symptoms & Phenotypes for Retinal Vascular Occlusion

UMLS symptoms related to Retinal Vascular Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 APOH F2 F5 MTHFR PGF PLG
2 cardiovascular system MP:0005385 10.01 F2 F5 PGF PLG SELP SERPINC1
3 integument MP:0010771 9.87 F2 F5 MTHFR PGF PLG SELP
4 mortality/aging MP:0010768 9.81 APOH F2 F5 MTHFR PLG SELP
5 liver/biliary system MP:0005370 9.73 F5 MTHFR PLG SELP SERPINC1 VEGFA
6 nervous system MP:0003631 9.56 F2 F5 MTHFR PLG SELP SERPINC1
7 vision/eye MP:0005391 9.1 MTHFR PGF PLG SELP SERPINC1 VEGFA

Drugs & Therapeutics for Retinal Vascular Occlusion

Drugs for Retinal Vascular Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 2 216974-75-3
2 Mitogens Phase 2
3 Endothelial Growth Factors Phase 2
4 Angiogenesis Inhibitors Phase 2
5 Angiogenesis Modulating Agents Phase 2
6
Bazedoxifene Approved, Investigational 198481-32-2
7 Antibodies
8 Immunoglobulins
9 Estrogen Antagonists
10 Hormones, Hormone Substitutes, and Hormone Antagonists
11 Raloxifene Hydrochloride
12 Estrogen Receptor Modulators
13 Selective Estrogen Receptor Modulators
14 Hormones
15 Diphosphonates
16 Estrogens
17 Estrogen Receptor Antagonists
18 Hormone Antagonists
19 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bevacizumab and Retinal Vascular Occlusions Unknown status NCT00347711 Phase 3 Intravitreal injection
2 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
3 Body-fluid Balance and Drinking Habits in Patients With Retinal Vascular Occlusion Unknown status NCT01939119
4 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862 Not Applicable
5 Ocular Findings in Women With Primary Antiphospholipid Syndrome Completed NCT03459508
6 Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older Completed NCT02160340
7 Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU) Active, not recruiting NCT01416194 Bazedoxifene;Bisphosphonate;Raloxifene
8 Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging Terminated NCT01834196 Not Applicable

Search NIH Clinical Center for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

Anatomical Context for Retinal Vascular Occlusion

MalaCards organs/tissues related to Retinal Vascular Occlusion:

41
Eye, Liver, Heart, Spinal Cord, Placenta

Publications for Retinal Vascular Occlusion

Articles related to Retinal Vascular Occlusion:

(show top 50) (show all 73)
# Title Authors Year
1
Paracentral Acute Middle Maculopathy and the Ischemic Cascade Associated With Retinal Vascular Occlusion. ( 30081014 )
2018
2
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
3
Retinal Vascular Occlusion Secondary to Retrobulbar Injection: Case Report and Literature Review. ( 28546695 )
2017
4
[Retinal vascular occlusion and polymorphisms in genes coding for components of vitamin K cycle]. ( 28635929 )
2016
5
SEVERE BILATERAL RETINAL VASCULAR OCCLUSION AS FIRST PRESENTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME. ( 27548039 )
2016
6
Risk of Mortality and of Atherosclerotic Events Among Patients Who Underwent Hemodialysis and Subsequently Developed Retinal Vascular Occlusion: A Taiwanese Retrospective Cohort Study. ( 26720586 )
2016
7
Venous thromboembolism does not share familial susceptibility with retinal vascular occlusion or glaucoma: a nationwide family study. ( 27283943 )
2016
8
Retinal vascular occlusion: a window to diagnosis of familial and acquired thrombophilia and hypofibrinolysis, with important ramifications for pregnancy outcomes. ( 27563233 )
2016
9
Pipeline embolization device: a new source for embolic retinal vascular occlusion. ( 24051422 )
2013
10
Impact of cilostazol on the progression of carotid atherosclerosis in patients with retinal vascular occlusion. ( 24034133 )
2013
11
Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. ( 23869159 )
2013
12
Thrombophilia and retinal vascular occlusion. ( 22969282 )
2012
13
Central retinal vascular occlusion associated with acute retinal necrosis. ( 22491922 )
2012
14
Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia-observational case series and survey of literature. ( 21850439 )
2011
15
Retinal vascular occlusion during in vitro fertilization. ( 25390129 )
2010
16
Factor V Leiden mutation with retinal vascular occlusion. ( 21199226 )
2010
17
Retinal vascular occlusion syndromes. ( 19584622 )
2009
18
Low density lipoprotein triglycerides and lipoprotein(a) are risk factors for retinal vascular occlusion. ( 17481600 )
2007
19
Inappropriate investigation and management of a retinal vascular occlusion. ( 16082396 )
2006
20
Retinal vascular occlusion in patients infected with human immunodeficiency virus. ( 16141865 )
2005
21
[The characteristics of retinitis pigmentosa with retinal vascular occlusion]. ( 15938805 )
2005
22
Retinal vascular occlusion following ocular contusion. ( 15931542 )
2005
23
Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor. ( 15710833 )
2005
24
Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy. ( 16197292 )
2005
25
Retinal vascular occlusion following traumatic hyphema and glaucoma, as a presenting sign of sickle cell trait. ( 16011069 )
2005
26
Hyperhomocysteinaemia: risk of retinal vascular occlusion. ( 16335656 )
2004
27
Central retinal vascular occlusion by orbital pseudotumor. ( 15187672 )
2004
28
Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with BehAset's disease. ( 12881356 )
2003
29
Unilateral peripheral retinal vascular occlusion in a young Japanese woman with neurofibromatosis-1. ( 12972769 )
2003
30
[Thrombophilia factors as inducers of retinal vascular occlusion]. ( 11450475 )
2001
31
[Retinal vascular occlusion and primary antiphospholipid syndrome. Report of 2 cases]. ( 11912840 )
2001
32
The electroretinogram in patients with retinal vascular occlusion. ( 12567597 )
2001
33
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10653432 )
2000
34
Systemic disorders associated with retinal vascular occlusion. ( 11141642 )
2000
35
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10653431 )
2000
36
Genetic thrombophilia in patients with retinal vascular occlusion. ( 11456253 )
1999
37
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10482096 )
1999
38
Monitoring of the thromboxane A2/prostacyclin ratio in the urine of patients with retinal vascular occlusion through the low-dose-aspirin therapy using the gas chromatography/selected ion monitoring method. ( 10593167 )
1999
39
Abnormalities in haemorheological factors and lipoprotein (a) in retinal vascular occlusion: implications for increased vascular risk. ( 9683948 )
1998
40
Visual field loss caused by retinal vascular occlusion after vitrectomy surgery. ( 9152086 )
1997
41
Peripheral retinal neovascularization and retinal vascular occlusion associated with activated protein C resistance. ( 9372725 )
1997
42
Cocaine-associated retinal vascular occlusion: report of two cases. ( 8059789 )
1994
43
[Mitral valve prolapse. A possible cause of retinal vascular occlusion in young patients]. ( 8219635 )
1993
44
Lipoprotein (a): a risk factor for retinal vascular occlusion. ( 1477637 )
1992
45
The investigation of patients with retinal vascular occlusion. ( 2209910 )
1990
46
Massive bilateral retinal vascular occlusion. ( 2475899 )
1989
47
Retinal vascular occlusion without retrobulbar or optic nerve sheath hemorrhage after retrobulbar injection of lidocaine. ( 3231409 )
1988
48
Massive bilateral retinal vascular occlusion secondary to thrombotic thrombocytopenic purpura. ( 2976518 )
1988
49
Experimental retinal vascular occlusion. III. An ultrastructural study of simultaneous occlusion of central retinal vein and artery. ( 3721722 )
1986
50
Experimental retinal vascular occlusion. II. A clinico-pathologic correlative study of simultaneous occlusion of central retinal vein and artery. ( 3721721 )
1986

Variations for Retinal Vascular Occlusion

Expression for Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for Retinal Vascular Occlusion

Pathways related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 APOH F2 F5 PLG SELP SERPINC1
2
Show member pathways
11.89 CCL2 F2 MTHFR PLG
3
Show member pathways
11.66 F2 F5 PLG SERPINC1
4 11.4 F2 F5 PLG SERPINC1
5 10.99 F2 PLG
6 10.89 SERPINC1 VEGFA
7 10.85 CCL2 F2
8 10.76 F2 PLG
9 10.68 CCL2 VEGFA
10
Show member pathways
10.57 PGF VEGFA
11 10.5 F2 VKORC1

GO Terms for Retinal Vascular Occlusion

Cellular components related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 APOH CCL2 F2 F5 PGF PLG
2 blood microparticle GO:0072562 9.43 F2 PLG SERPINC1
3 platelet alpha granule lumen GO:0031093 9.33 F5 PLG VEGFA
4 extracellular space GO:0005615 9.28 APOH CCL2 F2 F5 PGF PLG

Biological processes related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.84 CCL2 F2 PGF VEGFA
2 positive regulation of protein phosphorylation GO:0001934 9.74 F2 PGF VEGFA
3 response to hypoxia GO:0001666 9.73 MTHFR PGF VEGFA
4 blood coagulation GO:0007596 9.72 F2 F5 PLG SERPINC1 VKORC1
5 regulation of cell shape GO:0008360 9.7 CCL2 F2 VEGFA
6 cellular protein metabolic process GO:0044267 9.67 F2 F5 PLG SERPINC1
7 sprouting angiogenesis GO:0002040 9.58 PGF VEGFA
8 fibrinolysis GO:0042730 9.55 F2 PLG
9 blood coagulation, intrinsic pathway GO:0007597 9.51 APOH F2
10 vascular endothelial growth factor signaling pathway GO:0038084 9.49 PGF VEGFA
11 induction of positive chemotaxis GO:0050930 9.48 PGF VEGFA
12 positive regulation of blood coagulation GO:0030194 9.46 APOH F2
13 hemostasis GO:0007599 9.46 F2 F5 PLG SERPINC1
14 positive regulation of leukocyte migration GO:0002687 9.43 SELP VEGFA
15 negative regulation of fibrinolysis GO:0051918 9.43 APOH F2 PLG
16 positive regulation of mast cell chemotaxis GO:0060754 9.4 PGF VEGFA
17 platelet degranulation GO:0002576 9.35 APOH F5 PLG SELP VEGFA
18 regulation of blood coagulation GO:0030193 8.92 APOH F2 SERPINC1 VKORC1

Molecular functions related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 F2 PGF VEGFA
2 lipopolysaccharide binding GO:0001530 9.26 F2 SELP
3 heparin binding GO:0008201 9.1 APOH F2 PGF SELP SERPINC1 VEGFA
4 vascular endothelial growth factor receptor 3 binding GO:0043185 8.96 PGF VEGFA

Sources for Retinal Vascular Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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