MCID: RTN021
MIFTS: 43

Retinal Vascular Occlusion

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Retinal Vascular Occlusion

MalaCards integrated aliases for Retinal Vascular Occlusion:

Name: Retinal Vascular Occlusion 12 55 15 73
Retinal Vasc. Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1729
ICD10 33 H34 H34.9
ICD9CM 35 362.3 362.30
NCIt 50 C34980
UMLS 73 C0035326

Summaries for Retinal Vascular Occlusion

MalaCards based summary : Retinal Vascular Occlusion, also known as retinal vasc. occlusion, is related to central retinal artery occlusion and papilledema, and has symptoms including amaurosis fugax An important gene associated with Retinal Vascular Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Bevacizumab and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Retinal Vascular Occlusion

Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 30.7 FANCG PLG
2 papilledema 30.2 APOH F2
3 retinal vasculitis 29.7 APOH CCL2
4 atrial fibrillation 29.6 F2 SELP VKORC1
5 purpura 29.5 APOH F2 SERPINC1
6 central retinal vein occlusion 29.4 APOH F2 F5 MTHFR SERPINC1 VEGFA
7 nonarteritic anterior ischemic optic neuropathy 28.8 F2 F5 MTHFR SERPINC1
8 ischemic optic neuropathy 28.6 APOH F2 F5 MTHFR SERPINC1
9 arteritic anterior ischemic optic neuropathy 28.5 F2 F5 FANCG MTHFR
10 retinal artery occlusion 28.4 APOH F2 F5 MTHFR SERPINC1
11 thrombophilia 28.1 APOH F2 F5 MTHFR PLG SERPINC1
12 antiphospholipid syndrome 28.1 APOH F2 F5 MTHFR SELP SERPINC1
13 branch retinal artery occlusion 27.8 APOH F2 FANCG MTHFR SERPINC1
14 retinal vein occlusion 26.2 APOH CCL2 F2 F5 MTHFR SERPINC1
15 may-thurner syndrome 10.8 APOH F5
16 acanthamoeba keratitis 10.8 APOH F5
17 pregnancy loss, recurrent 1 10.7 APOH F5
18 retinitis 10.6
19 inferior vena cava interruption 10.6 F5 MTHFR
20 amaurosis fugax 10.6 F5 MTHFR
21 vitreous detachment 10.6 PLG VEGFA
22 heparin-induced thrombocytopenia 10.6 SELP SERPINC1
23 hemifacial spasm 10.6 MTHFR VEGFA
24 chronic myocardial ischemia 10.6 PLG VEGFA
25 platelet aggregation, spontaneous 10.6 SELP SERPINC1
26 sticky platelet syndrome 10.5 F5 SERPINC1
27 blood group, globoside system 10.5 PLG VEGFA
28 carotid artery occlusion 10.5 APOH F5
29 endophthalmitis 10.5 PLG VEGFA
30 paracetamol poisoning 10.5 F2 F5
31 qualitative platelet defect 10.5 F2 SELP
32 vitamin k deficiency hemorrhagic disease 10.5 F2 VKORC1
33 splenic infarction 10.5 APOH F2
34 hemoglobin e disease 10.4 F2 F5
35 lateral medullary syndrome 10.4 APOH PLG
36 mitral valve stenosis 10.4 SELP SERPINC1
37 cerebral falx meningioma 10.4 F2 PLG
38 factor viii deficiency 10.4 F2 F5
39 retinal disease 10.4
40 neovascular glaucoma 10.4 PGF VEGFA
41 meningococcemia 10.4 F5 SERPINC1
42 mesenteric vascular occlusion 10.4 F2 MTHFR
43 femoral neuropathy 10.4 F2 PLG
44 quebec platelet disorder 10.4 F5 SELP
45 anterior cranial fossa meningioma 10.4 F2 PLG
46 epithelioid hemangioendothelioma 10.4 PGF VEGFA
47 lemierre's syndrome 10.3 MTHFR PLG
48 kuhnt-junius degeneration 10.3 PGF VEGFA
49 ischemic neuropathy 10.3 F2 MTHFR
50 acute hemorrhagic leukoencephalitis 10.3 SERPINC1 VEGFA

Comorbidity relations with Retinal Vascular Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to Retinal Vascular Occlusion

Symptoms & Phenotypes for Retinal Vascular Occlusion

UMLS symptoms related to Retinal Vascular Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.02 VEGFA MTHFR VKORC1 PGF PLG SELP
2 cardiovascular system MP:0005385 9.97 VEGFA VKORC1 PGF PLG SELP F2
3 mortality/aging MP:0010768 9.81 F5 VEGFA MTHFR VKORC1 PLG APOH
4 integument MP:0010771 9.8 VEGFA MTHFR PGF PLG SELP F2
5 nervous system MP:0003631 9.56 F5 VEGFA MTHFR VKORC1 PLG SELP
6 vision/eye MP:0005391 9.1 VEGFA MTHFR PGF PLG SELP SERPINC1

Drugs & Therapeutics for Retinal Vascular Occlusion

Drugs for Retinal Vascular Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 2 216974-75-3
2 Mitogens Phase 2
3 Angiogenesis Inhibitors Phase 2
4 Angiogenesis Modulating Agents Phase 2
5 Endothelial Growth Factors Phase 2
6
Bazedoxifene Approved, Investigational 198481-32-2
7 Selective Estrogen Receptor Modulators
8 Hormone Antagonists
9 Diphosphonates
10 Hormones
11 Hormones, Hormone Substitutes, and Hormone Antagonists
12 Estrogen Antagonists
13 Estrogen Receptor Modulators
14 Estrogens
15 Raloxifene Hydrochloride
16 Bone Density Conservation Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bevacizumab and Retinal Vascular Occlusions Unknown status NCT00347711 Phase 3 Intravitreal injection
2 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
3 Body-fluid Balance and Drinking Habits in Patients With Retinal Vascular Occlusion Unknown status NCT01939119
4 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862 Not Applicable
5 Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older Completed NCT02160340
6 Ocular Findings in Women With Primary Antiphospholipid Syndrome Recruiting NCT03459508
7 Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU) Active, not recruiting NCT01416194 Bazedoxifene;Bisphosphonate;Raloxifene
8 Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging Terminated NCT01834196 Not Applicable

Search NIH Clinical Center for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

Anatomical Context for Retinal Vascular Occlusion

MalaCards organs/tissues related to Retinal Vascular Occlusion:

41
Eye, Endothelial, Bone

Publications for Retinal Vascular Occlusion

Articles related to Retinal Vascular Occlusion:

(show top 50) (show all 79)
# Title Authors Year
1
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
2
Retinal Vascular Occlusion Secondary to Retrobulbar Injection: Case Report and Literature Review. ( 28546695 )
2017
3
[Retinal vascular occlusion and polymorphisms in genes coding for components of vitamin K cycle]. ( 28635929 )
2016
4
SEVERE BILATERAL RETINAL VASCULAR OCCLUSION AS FIRST PRESENTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME. ( 27548039 )
2016
5
ADULT WITH CHICKENPOX COMPLICATED BY SYSTEMIC VASCULITIS AND BILATERAL RETINAL VASCULITIS WITH RETINAL VASCULAR OCCLUSIONS. ( 27533640 )
2016
6
Risk of Mortality and of Atherosclerotic Events Among Patients Who Underwent Hemodialysis and Subsequently Developed Retinal Vascular Occlusion: A Taiwanese Retrospective Cohort Study. ( 26720586 )
2016
7
Venous thromboembolism does not share familial susceptibility with retinal vascular occlusion or glaucoma: a nationwide family study. ( 27283943 )
2016
8
Retinal vascular occlusion: a window to diagnosis of familial and acquired thrombophilia and hypofibrinolysis, with important ramifications for pregnancy outcomes. ( 27563233 )
2016
9
Pipeline embolization device: a new source for embolic retinal vascular occlusion. ( 24051422 )
2013
10
Impact of cilostazol on the progression of carotid atherosclerosis in patients with retinal vascular occlusion. ( 24034133 )
2013
11
Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. ( 23869159 )
2013
12
Thrombophilia and retinal vascular occlusion. ( 22969282 )
2012
13
Central retinal vascular occlusion associated with acute retinal necrosis. ( 22491922 )
2012
14
Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia-observational case series and survey of literature. ( 21850439 )
2011
15
Retinal vascular occlusions occur more frequently in the more affected eye in exfoliation syndrome. ( 19557023 )
2010
16
Retinal vascular occlusion during in vitro fertilization. ( 25390129 )
2010
17
Factor V Leiden mutation with retinal vascular occlusion. ( 21199226 )
2010
18
Retinal vascular occlusion syndromes. ( 19584622 )
2009
19
Paroxysmal nocturnal hemoglobinuria may cause retinal vascular occlusions. ( 18437293 )
2009
20
Retinal vascular occlusions: an interdisciplinary challenge. ( 19626196 )
2008
21
Role of hyperhomocystinemia in retinal vascular occlusive disease. ( 17164500 )
2007
22
Low density lipoprotein triglycerides and lipoprotein(a) are risk factors for retinal vascular occlusion. ( 17481600 )
2007
23
Inappropriate investigation and management of a retinal vascular occlusion. ( 16082396 )
2006
24
Retinal vascular occlusion in patients infected with human immunodeficiency virus. ( 16141865 )
2005
25
[The characteristics of retinitis pigmentosa with retinal vascular occlusion]. ( 15938805 )
2005
26
Retinal vascular occlusion following ocular contusion. ( 15931542 )
2005
27
Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor. ( 15710833 )
2005
28
Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy. ( 16197292 )
2005
29
Retinal vascular occlusion following traumatic hyphema and glaucoma, as a presenting sign of sickle cell trait. ( 16011069 )
2005
30
Hyperhomocysteinaemia: risk of retinal vascular occlusion. ( 16335656 )
2004
31
Central retinal vascular occlusion by orbital pseudotumor. ( 15187672 )
2004
32
Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with BehAset's disease. ( 12881356 )
2003
33
Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. ( 14644226 )
2003
34
Unilateral peripheral retinal vascular occlusion in a young Japanese woman with neurofibromatosis-1. ( 12972769 )
2003
35
[Thrombophilia factors as inducers of retinal vascular occlusion]. ( 11450475 )
2001
36
Thermolabile MTHFR genotype and retinal vascular occlusive disease. ( 11133719 )
2001
37
[Retinal vascular occlusion and primary antiphospholipid syndrome. Report of 2 cases]. ( 11912840 )
2001
38
The electroretinogram in patients with retinal vascular occlusion. ( 12567597 )
2001
39
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10653432 )
2000
40
Systemic disorders associated with retinal vascular occlusion. ( 11141642 )
2000
41
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10653431 )
2000
42
Genetic thrombophilia in patients with retinal vascular occlusion. ( 11456253 )
1999
43
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10482096 )
1999
44
Abnormalities in haemorheological factors and lipoprotein (a) in retinal vascular occlusion: implications for increased vascular risk. ( 9683948 )
1998
45
Visual field loss caused by retinal vascular occlusion after vitrectomy surgery. ( 9152086 )
1997
46
Peripheral retinal neovascularization and retinal vascular occlusion associated with activated protein C resistance. ( 9372725 )
1997
47
Antiphospholipid antibodies in retinal vascular occlusions. A prospective study of 75 patients. ( 8002838 )
1994
48
Cocaine-associated retinal vascular occlusion: report of two cases. ( 8059789 )
1994
49
[Mitral valve prolapse. A possible cause of retinal vascular occlusion in young patients]. ( 8219635 )
1993
50
Lipoprotein (a): a risk factor for retinal vascular occlusion. ( 1477637 )
1992

Variations for Retinal Vascular Occlusion

Expression for Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for Retinal Vascular Occlusion

Pathways related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.25 APOH F2 F5 PLG SELP SERPINC1
2
Show member pathways
11.89 CCL2 F2 MTHFR PLG
3
Show member pathways
11.66 F2 F5 PLG SERPINC1
4 11.4 F2 F5 PLG SERPINC1
5 10.99 F2 PLG
6 10.89 SERPINC1 VEGFA
7 10.85 CCL2 F2
8 10.76 F2 PLG
9 10.68 CCL2 VEGFA
10
Show member pathways
10.57 PGF VEGFA
11 10.5 F2 VKORC1

GO Terms for Retinal Vascular Occlusion

Cellular components related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 APOH CCL2 F2 F5 PGF PLG
2 blood microparticle GO:0072562 9.43 F2 PLG SERPINC1
3 platelet alpha granule lumen GO:0031093 9.33 F5 PLG VEGFA
4 extracellular space GO:0005615 9.28 APOH CCL2 F2 F5 PGF PLG

Biological processes related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.84 CCL2 F2 PGF VEGFA
2 response to hypoxia GO:0001666 9.73 MTHFR PGF VEGFA
3 regulation of cell shape GO:0008360 9.72 CCL2 F2 VEGFA
4 cellular protein metabolic process GO:0044267 9.67 F2 F5 PLG SERPINC1
5 blood coagulation GO:0007596 9.65 F2 F5 PLG SERPINC1 VKORC1
6 fibrinolysis GO:0042730 9.52 F2 PLG
7 blood coagulation, intrinsic pathway GO:0007597 9.51 APOH F2
8 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
9 positive regulation of leukocyte migration GO:0002687 9.49 SELP VEGFA
10 positive regulation of blood coagulation GO:0030194 9.48 APOH F2
11 induction of positive chemotaxis GO:0050930 9.46 PGF VEGFA
12 peptidyl-glutamic acid carboxylation GO:0017187 9.43 F2 VKORC1
13 positive regulation of mast cell chemotaxis GO:0060754 9.4 PGF VEGFA
14 negative regulation of fibrinolysis GO:0051918 9.33 APOH F2 PLG
15 hemostasis GO:0007599 9.26 F2 F5 PLG SERPINC1
16 platelet degranulation GO:0002576 9.02 APOH F5 PLG SELP VEGFA

Molecular functions related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 F2 PGF VEGFA
2 lipopolysaccharide binding GO:0001530 9.26 F2 SELP
3 heparin binding GO:0008201 9.1 APOH F2 PGF SELP SERPINC1 VEGFA
4 vascular endothelial growth factor receptor binding GO:0005172 8.96 PGF VEGFA

Sources for Retinal Vascular Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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