MCID: RTN001
MIFTS: 45

Retinal Vasculitis

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Vasculitis

MalaCards integrated aliases for Retinal Vasculitis:

Name: Retinal Vasculitis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11563
ICD10 33 H35.06
ICD9CM 35 362.18
MeSH 44 D031300
SNOMED-CT 68 77628002
UMLS 73 C0152026

Summaries for Retinal Vasculitis

Disease Ontology : 12 A vasculitis that is characterized by inflammation of the vascular branches of the retinal artery and has symptom painless decrease of visual acuity, visual floaters, dark spot in vision, decreased ability to distinguish colors, and distortion of images such as linear images.

MalaCards based summary : Retinal Vasculitis is related to eales disease and retinal vein occlusion, and has symptoms including painless decrease of visual acuity and eye manifestations. An important gene associated with Retinal Vasculitis is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Dendritic Cells Developmental Lineage Pathway. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Retinal vasculitis is inflammation of the vascular branches of the retinal artery, caused either by... more...

Related Diseases for Retinal Vasculitis

Diseases related to Retinal Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 143)
# Related Disease Score Top Affiliating Genes
1 eales disease 32.2 NOS2 SAG
2 retinal vein occlusion 30.2 APOH CCL2
3 temporal arteritis 29.9 APOH CCL2
4 systemic lupus erythematosus 29.9 APOH CCL2 IFNB1 TLR3
5 multiple sclerosis 29.4 CCL2 IFNB1 NOS2
6 irvan syndrome 12.0
7 vasculitis 11.0
8 neuroretinitis 10.6
9 uveitis 10.4
10 lupus erythematosus 10.3
11 cataract 10.2
12 retinitis 10.2
13 retinal vascular occlusion 10.1 APOH CCL2
14 autoimmune uveitis 10.1 CCL2 SAG
15 degeneration of macula and posterior pole 10.1 CCL2 CX3CR1
16 lymphoma 10.1
17 scleritis 10.1
18 endophthalmitis 10.1
19 transient cerebral ischemia 10.1 APOH CCL2
20 extrinsic cardiomyopathy 10.0 CCL2 IFNB1
21 yellow fever 10.0 CCL2 IFNB1
22 rheumatoid arthritis 10.0
23 west nile virus 10.0
24 arthritis 10.0
25 crohn's disease 10.0
26 choroiditis 10.0
27 intermediate uveitis 10.0
28 mixed connective tissue disease 10.0
29 syphilis 10.0
30 connective tissue disease 10.0
31 retinal artery occlusion 10.0
32 chickenpox 10.0
33 anterior uveitis 10.0
34 severe acute respiratory syndrome 10.0 CCL2 IFNB1
35 immunodeficiency, x-linked, with magnesium defect, epstein-barr virus infection, and neoplasia 10.0 IFNB1 TLR3
36 japanese encephalitis 10.0 IFNB1 TLR3
37 autoimmune disease 10.0 APOH CCL2 SAG
38 borderline leprosy 10.0 APOH NOS2
39 secondary progressive multiple sclerosis 10.0 CCL2 IFNB1
40 autoimmune disease of central nervous system 10.0 CCL2 IFNB1
41 diabetic angiopathy 10.0 CCL2 NOS2
42 polyarteritis nodosa, childhood-onset 10.0
43 panuveitis 10.0
44 optic neuritis 10.0
45 branch retinal artery occlusion 10.0
46 neuritis 10.0
47 optic nerve disease 10.0
48 melanoma 10.0
49 central retinal vein occlusion 10.0
50 macular retinal edema 10.0

Graphical network of the top 20 diseases related to Retinal Vasculitis:



Diseases related to Retinal Vasculitis

Symptoms & Phenotypes for Retinal Vasculitis

Symptoms:

12
  • painless decrease of visual acuity

UMLS symptoms related to Retinal Vasculitis:


eye manifestations

GenomeRNAi Phenotypes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 CX3CR1 NOS2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 NOS2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.64 NOS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 APOH CX3CR1 NOS2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 CX3CR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.64 CX3CR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.64 CX3CR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.64 NOS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.64 NOS2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.64 NOS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 APOH
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 APOH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.64 CX3CR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 NOS2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 APOH CX3CR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.64 NOS2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.64 NOS2

Drugs & Therapeutics for Retinal Vasculitis

Drugs for Retinal Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
3
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Not Applicable 2921-57-5
5
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Not Applicable 2920-86-7
6 Gastrointestinal Agents Phase 4,Not Applicable
7 Antineoplastic Agents, Hormonal Phase 4,Not Applicable
8 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2,Not Applicable
9 Hormone Antagonists Phase 4,Phase 2,Not Applicable
10 Prednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
11 Neuroprotective Agents Phase 4,Not Applicable
12 glucocorticoids Phase 4,Not Applicable
13 Antiemetics Phase 4,Not Applicable
14 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1,Not Applicable
15 Hormones Phase 4,Phase 2,Not Applicable
16 Autonomic Agents Phase 4,Not Applicable
17 Protective Agents Phase 4,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
19 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
20 beta-endorphin Phase 4,Phase 2
21 Adrenocorticotropic Hormone Phase 4,Phase 2
22 Melanocyte-Stimulating Hormones Phase 4,Phase 2
23
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
24
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
25 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
26 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
27 Dermatologic Agents Phase 3,Phase 2,Not Applicable
28 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
29 Interferon-alpha Phase 3
30 Antiviral Agents Phase 3
31 Cyclosporins Phase 3
32 Calcineurin Inhibitors Phase 3
33 Antifungal Agents Phase 3
34 interferons Phase 3
35 Anti-Infective Agents Phase 3,Phase 1,Phase 2
36 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
37 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
38
Methotrexate Approved Phase 2,Not Applicable 59-05-2, 1959-05-2 126941
39
rituximab Approved Phase 2 174722-31-7 10201696
40
Azathioprine Approved Phase 2 446-86-6 2265
41
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
42
Abatacept Approved Phase 2 332348-12-6 10237
43 tannic acid Approved Phase 2
44
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
45
Ustekinumab Approved, Investigational Phase 2 815610-63-0
46
Apremilast Approved, Investigational Phase 1, Phase 2 608141-41-9 11561674
47 Analgesics Phase 2,Phase 1,Not Applicable
48 Analgesics, Non-Narcotic Phase 2,Phase 1,Not Applicable
49 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2,Not Applicable
50 Interleukin-2 Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
2 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Active, not recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
3 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Completed NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
4 Lucentis (Ranibizumab) for Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab
5 Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's Disease Completed NCT00664599 Phase 2 Rituximab;Cytotoxic Combination
6 Abatacept in the Treatment of Uveitis Completed NCT01279954 Phase 2 Abatacept
7 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
8 HAT in Eye Complications of Behcet's Disease Completed NCT00001865 Phase 2 Daclizumab
9 Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease Recruiting NCT02648581 Phase 2 Subcutaneous Ustekinumab
10 ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) Recruiting NCT02931175 Phase 2 ACTH gel
11 Apremilast in the Treatment of Uveitis Terminated NCT00889421 Phase 1, Phase 2 Apremilast
12 Stem Cell Transplantation in Ocular Lesions of Behcet's Disease Terminated NCT00550498 Phase 1
13 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Not Applicable Etanercept, Methotrexate, Prednisolone
14 Biological Markers in Retinal Vasculitis Completed NCT00050492
15 Optical Coherence Tomography (OCT) in Retinal Vasculitis Recruiting NCT01998464
16 Evaluation of Macular Vascular Changes in Behcet's Disease Using Optical Coherence Tomography Angiography Recruiting NCT03264391

Search NIH Clinical Center for Retinal Vasculitis

Cochrane evidence based reviews: retinal vasculitis

Genetic Tests for Retinal Vasculitis

Anatomical Context for Retinal Vasculitis

MalaCards organs/tissues related to Retinal Vasculitis:

41
Eye, T Cells, Bone, Testes, Skin, Myeloid, Neutrophil

Publications for Retinal Vasculitis

Articles related to Retinal Vasculitis:

(show top 50) (show all 403)
# Title Authors Year
1
Retinal vasculitis and Eales disease. ( 29599058 )
2018
2
Efficacy of adalimumab and infliximab in recalcitrant retinal vasculitis inadequately responsive to other immunomodulatory therapies. ( 29766375 )
2018
3
Evaluation of efficacy of infliximab for retinal vasculitis and extraocular symptoms in BehAset disease. ( 29582190 )
2018
4
Retinal Vasculitis in Takayasu's Arteritis. ( 29791818 )
2018
5
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). ( 29406987 )
2018
6
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis. ( 29059086 )
2018
7
Hemorrhagic Ischemic Retinal Vasculitis and Alopecia Areata as a Manifestation of HLA-B27. ( 29304269 )
2018
8
THE COLLABORATIVE OCULAR TUBERCULOSIS STUDY (COTS)-1: A Multinational Review of 251 Patients With Tubercular Retinal Vasculitis. ( 29697588 )
2018
9
Vancomycin-associated hemorrhagic occlusive retinal vasculitis: a clinical-pathophysiological analysis. ( 29425799 )
2018
10
Mild Bilateral Hemorrhagic Occlusive Retinal Vasculitis Following Intracameral Vancomycin Administration in Cataract Surgery. ( 29772049 )
2018
11
HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AFTER INTRACAMERAL VANCOMYCIN USE IN CATARACT SURGERY AFTER INTRAVENOUS EXPOSURE. ( 29474222 )
2018
12
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis: Erratum. ( 29782408 )
2018
13
Retinal vasculitis associated with CREST syndrome. ( 29780934 )
2018
14
Macular changes in retinal vasculitis. ( 29480259 )
2018
15
Pathogenesis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) or 'idiopathic retinal arteriolar aneurysms (IRAA)' with macular star. ( 29447942 )
2018
16
A new perspective for analyzing clinical characteristics of idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. ( 29934930 )
2018
17
SjAPgren's Disease Associated with Severe Retinal Vasculitis and/or Necrotizing Scleritis: Two Cases. ( 29452446 )
2018
18
Varicella-zoster virus necrotising retinitis, retinal vasculitis and panuveitis following uncomplicated chickenpox in an immunocompetent child. ( 29622711 )
2018
19
Resolution of arterial aneurysms in idiopathic retinal vasculitis, aneurysms and neuroretinitis: a case report and review of literature. ( 29594790 )
2018
20
Comparison between optical coherence tomography angiography and fluorescein angiography findings in retinal vasculitis. ( 29692926 )
2018
21
Macrophage Activation Syndrome, Glomerulonephritis, Pericarditis, and Retinal Vasculitis as Initial Presentation of Systemic Lupus Erythematosus. ( 30356389 )
2018
22
Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography. ( 30538102 )
2018
23
Long-term outcomes in a series of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome. ( 30340706 )
2018
24
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis. ( 30038179 )
2018
25
Evolution of a severe case of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) during pregnancy. ( 30389182 )
2018
26
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) in a Patient Without IRVAN History. ( 30419083 )
2018
27
Tubercular retinal vasculitis mimicking frosted branch angiitis: a case report. ( 29356903 )
2018
28
Secondary Coats' response to retinal vasculitis managed with bevacizumab. ( 30127171 )
2018
29
Ultra-Wide Field Imaging Characteristics of Primary Retinal Vasculitis: Risk Factors for Retinal Neovascularization. ( 30207804 )
2018
30
Postoperative Hemorrhagic Occlusive Retinal Vasculitis with Intracameral Vancomycin. ( 30311469 )
2018
31
Retinal Vasculitis Is Principally a Single-Organ Vasculitis of the Eye. ( 29280823 )
2017
32
Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography. ( 28844053 )
2017
33
Retinal vasculitis associated with cutaneous leukocytoclastic vasculitis. ( 29256164 )
2017
34
Clinical Outcome of Retinal Vasculitis and Predictors for Prognosis of Ischemic Retinal Vasculitis. ( 28263735 )
2017
35
Intracameral Antibiotics in the Shadow of Hemorrhagic Occlusive Retinal Vasculitis. ( 28433122 )
2017
36
Hemorrhagic occlusive retinal vasculitis after inadvertent intraocular perforation with gentamycin injection. ( 28233891 )
2017
37
Ultra-wide imaging in a case of retinal vasculitis with macular star. ( 29054905 )
2017
38
RETINAL VASCULITIS ASSOCIATED WITH NEUROMYELITIS OPTICA. ( 27820753 )
2017
39
Clinical Features and Incidence Rates of Ocular Complications in Patients With Retinal Vasculitis. ( 28501390 )
2017
40
TREATMENT OF IDIOPATHIC RETINAL VASCULITIS, ANEURYSMS, AND NEURORETINITIS (IRVAN) WITH PHOTOCOAGULATION IN COMBINATION WITH SYSTEMIC IMMUNOSUPPRESSION. ( 29261555 )
2017
41
Multimodal Imaging in Retinal Vasculitis. ( 28696172 )
2017
42
Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. ( 28724375 )
2017
43
Acute necrotizing retinal vasculitis as onset of systemic lupus erythematosus: A case report. ( 28079801 )
2017
44
Bilateral Branch Occlusive Retinal Vasculitis Induced by Septic Embo-lism in Endogenous Klebsiella Endo-phthalmitis. ( 28367048 )
2017
45
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
46
A New Complication Associated with the Use of Prophylactic Intracameral Antibiotics: Hemorrhagic Occlusive Retinal Vasculitis. ( 28433121 )
2017
47
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: clinical perspectives. ( 29062224 )
2017
48
Intravitreal bevacizumab in treatment of retinal neovascularization from tuberculous retinal vasculitis. ( 29062788 )
2017
49
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
50
Case of combination therapy to treat lupus retinal vasculitis refractory to steroids. ( 28237161 )
2017

Variations for Retinal Vasculitis

Expression for Retinal Vasculitis

Search GEO for disease gene expression data for Retinal Vasculitis.

Pathways for Retinal Vasculitis

GO Terms for Retinal Vasculitis

Cellular components related to Retinal Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 8.96 ARR3 SAG
2 photoreceptor inner segment GO:0001917 8.62 ARR3 SAG

Biological processes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.83 ARR3 CCL2 CX3CR1 SAG TLR3
2 cell surface receptor signaling pathway GO:0007166 9.58 CCL2 IFNB1 SAG
3 chemokine-mediated signaling pathway GO:0070098 9.49 CCL2 CX3CR1
4 cellular response to drug GO:0035690 9.48 NOS2 TLR3
5 humoral immune response GO:0006959 9.46 CCL2 IFNB1
6 cellular response to lipopolysaccharide GO:0071222 9.43 CCL2 CX3CR1 NOS2
7 response to exogenous dsRNA GO:0043330 9.37 IFNB1 TLR3
8 cellular response to interferon-beta GO:0035458 9.32 IFNB1 TLR3
9 cellular response to exogenous dsRNA GO:0071360 9.16 IFNB1 TLR3
10 cellular response to interferon-gamma GO:0071346 9.13 CCL2 NOS2 TLR3
11 cytokine-mediated signaling pathway GO:0019221 8.92 CCL2 CX3CR1 IFNB1 NOS2

Molecular functions related to Retinal Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphoprotein binding GO:0051219 8.96 ARR3 SAG
2 opsin binding GO:0002046 8.62 ARR3 SAG

Sources for Retinal Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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