MCID: RTN001
MIFTS: 46

Retinal Vasculitis

Categories: Cardiovascular diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Retinal Vasculitis

MalaCards integrated aliases for Retinal Vasculitis:

Name: Retinal Vasculitis 12 54 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11563
ICD9CM 34 362.18
MeSH 44 D031300
SNOMED-CT 67 77628002
ICD10 32 H35.06
UMLS 70 C0152026

Summaries for Retinal Vasculitis

Disease Ontology : 12 A vasculitis that is characterized by inflammation of the vascular branches of the retinal artery and has symptom painless decrease of visual acuity, visual floaters, dark spot in vision, decreased ability to distinguish colors, and distortion of images such as linear images.

MalaCards based summary : Retinal Vasculitis is related to eales disease and neuroretinitis, and has symptoms including painless decrease of visual acuity and eye manifestations. An important gene associated with Retinal Vasculitis is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Hormones and Adrenocorticotropic Hormone have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are immune system and nervous system

Wikipedia : 73 Retinal vasculitis is inflammation of the vascular branches of the retinal artery, caused either by... more...

Related Diseases for Retinal Vasculitis

Diseases related to Retinal Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 530)
# Related Disease Score Top Affiliating Genes
1 eales disease 31.2 TNF SOD1 SAG RBP3 NOS2
2 neuroretinitis 30.8 SAG CD4 ACE
3 retinal vascular disease 30.6 TNF CCL2 ACE
4 uveitis 30.6 TNF SAG RBP3 CCL4 CCL2
5 macular retinal edema 30.5 TNF IFNB1 CCL2 ACE
6 retinal artery occlusion 30.5 CCL2 APOH ACE
7 neuritis 30.3 TNF CX3CR1 CCL4 CCL2
8 scleritis 30.2 TNF CCR6 CCL2
9 ocular tuberculosis 30.2 CD4 ACE
10 retinal vein occlusion 30.1 TNF CCL2 APOH ACE
11 pulmonary tuberculosis 30.0 TNF CCL4 CCL2
12 posterior uveitis 29.9 TNF SAG RBP3 CCR6
13 rubella 29.9 TNF TLR3 IFNB1
14 optic papillitis 29.7 SAG RBP3 CD4 ACE
15 posterior scleritis 29.7 TNF ACE
16 dengue disease 29.7 TNF IFNB1 CCL4
17 iridocyclitis 29.6 TNF RBP3 CD4 ACE
18 papilledema 29.6 CD4 APOH ACE
19 chickenpox 29.6 TNF IFNB1 CD4 CCR6
20 cat-scratch disease 29.6 CD4 ACE
21 transverse myelitis 29.6 TNF CCR6 APOH
22 pyoderma 29.5 TNF CCR6 APOH
23 pyoderma gangrenosum 29.5 TNF CCR6 APOH
24 optic nerve disease 29.5 TNF IFNB1 CD4 CCR6
25 crohn's disease 29.5 TNF CD4 CCR6 CCL2
26 tonsillitis 29.5 TNF TLR3 SOD1 CX3CR1
27 crohn's colitis 29.4 TNF NOS2 CCR6
28 kawasaki disease 29.4 TNF CD4 CCL2
29 hypopyon 29.4 TNF RBP3 CD4
30 myelitis 29.4 TNF IFNB1 CCR6 APOH
31 granuloma annulare 29.4 TNF CD4
32 lung disease 29.4 TNF SOD1 CCL2 ACE
33 keratitis, hereditary 29.3 TNF CD4 CCR6
34 chorioretinitis 29.3 TNF SAG RBP3 CD4 ACE
35 syphilis 29.3 TNF CD4 CCR6 APOH ACE
36 granulomatosis with polyangiitis 29.3 TNF CD4 CCR6
37 meningoencephalitis 29.3 TNF CD4 CCR6
38 choroiditis 29.3 TNF SAG RBP3 CD4 ACE
39 sarcoidosis 1 29.2 TNF CD4 CCR6 CCL4 CCL2 ACE
40 mononeuritis multiplex 29.1 TNF CD4 ACE
41 abdominal tuberculosis 29.1 TNF CD4
42 panuveitis 29.0 TNF SAG RBP3 CD4 CCR6 ACE
43 myocarditis 29.0 TNF TLR3 NOS2 CCL2 ACE
44 mycobacterium tuberculosis 1 29.0 TNF IFNB1 CD4 CCR6 CCL4
45 encephalitis 29.0 TNF TLR3 NOS2 IFNB1 CCL4 CCL2
46 temporal arteritis 28.9 TNF CD4 CCR6 CCL2 APOH
47 macular degeneration, age-related, 1 28.9 TNF TLR3 SAG RBP3 CX3CR1 CCR6
48 exanthem 28.9 TNF CD4 CCR6 ACE
49 systemic scleroderma 28.9 TNF CD4 CCR6 ACE
50 vaginitis 28.9 TNF CD4 CCR6 CCL4

Graphical network of the top 20 diseases related to Retinal Vasculitis:



Diseases related to Retinal Vasculitis

Symptoms & Phenotypes for Retinal Vasculitis

Symptoms:

12
  • painless decrease of visual acuity

UMLS symptoms related to Retinal Vasculitis:


eye manifestations

MGI Mouse Phenotypes related to Retinal Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.96 ACE CCL2 CCR6 CD4 CX3CR1 IFNB1
2 nervous system MP:0003631 9.7 ACE CCR6 CD4 CX3CR1 IFNB1 NOS2
3 neoplasm MP:0002006 9.63 ACE IFNB1 NOS2 SOD1 TLR3 TNF
4 vision/eye MP:0005391 9.23 ACE ARR3 CX3CR1 NOS2 RBP3 SAG

Drugs & Therapeutics for Retinal Vasculitis

Drugs for Retinal Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 4
2 Adrenocorticotropic Hormone Phase 4
3 Melanocyte-Stimulating Hormones Phase 4
4 beta-Endorphin Phase 4
5
Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
8
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
9
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
10
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
11
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
12
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
13
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
14 Methylprednisolone Acetate Phase 3
15 Angiogenesis Inhibitors Phase 2, Phase 3
16 Cyclosporins Phase 3
17 Antirheumatic Agents Phase 3
18 Immunosuppressive Agents Phase 3
19 Antiviral Agents Phase 3
20 Immunologic Factors Phase 3
21 interferons Phase 3
22 Dermatologic Agents Phase 3
23 Interferon alpha-2 Phase 3
24 Interferon-alpha Phase 3
25 Anti-Infective Agents Phase 3
26 Antifungal Agents Phase 3
27 Calcineurin Inhibitors Phase 3
28 Autoantibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Efficacy of Intravenous Pulses of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease, a Double Blind Pilot Study Unknown status NCT01306955 Phase 4 methylorednisolone
2 Open-label, Single-center, Prospective Study on the Efficacy and Safety of Repository Corticotropin Injection (H.P. ACTHAR GEL) in the Treatment of Adults With Non-infectious Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
3 The Use of a VEGF Inhibitor (Lucentis) in Refractory Macular Edema Due to Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab
4 Phase III Study of Recombinant Human Interferon-alpha2a Versus Cyclosporin A for the Treatment of Ocular Behcet's Disease - a National,Randomised, Single-masked Controlled Trial (INCYTOB) Completed NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
5 Identification of Biological Markers in Retinal Vasculitis Completed NCT00050492
6 Evaluation of Macular Vascular Changes in Behcet's Disease Using Optical Coherence Tomography Angiography Completed NCT03264391
7 Evaluation of the Utility of OCT Angiography in Assessing Vascular Perfusion in Retinal Vasculitis Active, not recruiting NCT01998464

Search NIH Clinical Center for Retinal Vasculitis

Cochrane evidence based reviews: retinal vasculitis

Genetic Tests for Retinal Vasculitis

Anatomical Context for Retinal Vasculitis

MalaCards organs/tissues related to Retinal Vasculitis:

40
Eye, Endothelial, Retina, Skin, Brain, Monocytes, Bone Marrow

Publications for Retinal Vasculitis

Articles related to Retinal Vasculitis:

(show top 50) (show all 1284)
# Title Authors PMID Year
1
Primate model of uveoretinitis and vasculitis/experimental autoimmune uveoretinitis induced in cynomolgus monkeys by retinal s antigen. 54 61
18421236 2008
2
Anticardiolipin antibodies in isolated retinal vasculitis. 61 54
8250085 1993
3
Markers of vascular injury in Behçet's disease associated with retinal vasculitis. 61 54
1476395 1992
4
Antibody affinity to retinal S-antigen in patients with retinal vasculitis. 54 61
1598962 1992
5
Anticardiolipin antibodies in uveitis. 54 61
1424747 1992
6
A case of panuveitis and retinal vasculitis associated with pembrolizumab therapy for metastatic lung cancer. 61
33796799 2021
7
Drug-related adverse effects of antivascular endothelial growth factor agents. 61
33770015 2021
8
Multimodal imaging in infectious and noninfectious intermediate, posterior and panuveitis. 61
33710009 2021
9
Differing Risks of Occlusive Retinal Vasculitis with Concurrent Intraocular Inflammation Among Intravitreal Antivascular Endothelial Growth Factor Therapies. 61
33165295 2021
10
Posterior Uveitis Associated with Cemiplimab. 61
33793370 2021
11
Comparative study of adalimumab versus conventional therapy in sight-threatening refractory Behçet's uveitis with vasculitis. 61
33581500 2021
12
Complete response in a patient with lung cancer suffering from three pembrolizumab-induced immune-related adverse events including retinal vasculitis. 61
33732464 2021
13
Unilateral sub-macular hemorrhage- novel presentation of COVID-19 infection. 61
33792943 2021
14
[Intraocular inflammation with brolucizumab use : Patient management-diagnosis-therapy]. 61
33555415 2021
15
Three cases of brolucizumab-associated retinal vasculitis treated with systemic and local steroid therapy. 61
33543352 2021
16
Unilateral hypopyon associated acute syphilitic posterior placoid chorioretinitis: Unusual presentation leading to HIV diagnosis. 61
33779397 2021
17
Intravenous methylprednisolone induces rapid improvement in non-infectious uveitis: a multicentre study of 112 patients. 61
33666160 2021
18
A case of systemic lupus erythematosus with marked ascites due to idiopathic non-cirrhotic portal hypertension. 61
33783333 2021
19
Severe retinal vasculitis in systemic lupus erythematosus leading to vision threatening paracentral acute middle maculopathy. 61
33627049 2021
20
[Observational study of QuantiFERON® management for ocular tuberculosis diagnosis: Analysis of 244 consecutive tests]. 61
33143863 2021
21
RETINAL VASCULITIS, A COMMON MANIFESTATION OF IDIOPATHIC PEDIATRIC UVEITIS? 61
32658162 2021
22
Inflammatory Complications of Intravitreal Anti-VEGF Injections. 61
33801185 2021
23
Effectiveness of SB5, an Adalimumab Biosimilar, in Patients With Noninfectious Uveitis: A Real-Life Monocentric Experience. 61
33756492 2021
24
Drug-related adverse effects of antivascular endothelial growth factor agents. 61
33769327 2021
25
Behçet's disease presenting as bilateral occlusive retinal vasculitis in a young woman. 61
33664044 2021
26
Reperfusion of retinal ischemia in retinal occlusive vasculitis with nicotinic acid and infliximab in Adamantiades-Behçet's disease. 61
33615039 2021
27
Treatment Exit Options for Non-infectious Uveitis (TOFU): Study Protocol for a Prospective Clinical Registry. 61
33615986 2021
28
[Intraocular inflammation with occlusive retinal vasculitis following intravitreal injection of brolucizumab]. 61
33625559 2021
29
A Novel Method to Detect and Monitor Retinal Vasculitis Using Swept Source OCT Angiography. 61
33610835 2021
30
Immune-Mediated Retinal Vasculitis in Posterior Uveitis and Experimental Models: The Leukotriene (LT)B4-VEGF Axis. 61
33671954 2021
31
CLINICAL PREDICTORS OF TUBERCULAR RETINAL VASCULITIS IN A HIGH-ENDEMIC COUNTRY. 61
32383841 2021
32
Posterior pole retinal breaks causing posterior pole retinal detachment in a middle-aged man with retinal vasculitis and moderate myopia. 61
33637495 2021
33
[Ocular manifestations of Behçet's disease]. 61
33380351 2021
34
Early Experience With Brolucizumab Treatment of Neovascular Age-Related Macular Degeneration. 61
33630045 2021
35
Panuveitis in a patient with active Crohn's disease. 61
33541992 2021
36
Collaborative Ocular Tuberculosis Study Consensus Guidelines on the Management of Tubercular Uveitis-Report 2: Guidelines for Initiating Antitubercular Therapy in Anterior Uveitis, Intermediate Uveitis, Panuveitis, and Retinal Vasculitis. 61
32603726 2021
37
Prognosis of Ocular Tuberculosis Following Long-Term Antitubercular Therapy. 61
33524301 2021
38
HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AFTER INTRACAMERAL VANCOMYCIN USE IN CATARACT SURGERY AFTER INTRAVENOUS EXPOSURE. 61
29474222 2021
39
Multimodal Imaging of Parry Romberg Syndrome-associated Panuveitis: A Case Report and Review of Literature. 61
31577463 2021
40
Uveitis as an Open Window to Systemic Inflammatory Diseases. 61
33466638 2021
41
Clinical and Multimodal Imaging Clues in Differentiating Between Tuberculomas and Sarcoid Choroidal Granulomas. 61
33529591 2021
42
PR3-ANCA associated retinal vasculitis and atrial myxoma. 61
32778873 2021
43
Commonly used intracameral antibiotics for endophthalmitis prophylaxis: A literature review. 61
32343980 2021
44
Retinal vasculitis: A framework and proposal for a classification system. 61
32450158 2021
45
Confusional syndrome and retinal vasculitis. 61
31405588 2021
46
Vascular abnormalities in uveitis. 61
33412171 2021
47
Endophthalmitis after cataract surgery: an update on recent advances. 61
33196543 2021
48
Miliary Retinal Lesions in Ocular Syphilis: Imaging Characteristics and Outcomes. 61
31580177 2021
49
Is There a True Neuroretinitis in Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) Syndrome ? 61
33331800 2020
50
Concurrent chilblains and retinal vasculitis in a child with COVID-19. 61
32618041 2020

Variations for Retinal Vasculitis

Expression for Retinal Vasculitis

Search GEO for disease gene expression data for Retinal Vasculitis.

Pathways for Retinal Vasculitis

Pathways related to Retinal Vasculitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 TNF NOS2 IFNB1 CX3CR1 CD4 CCR6
2
Show member pathways
13.2 TNF TLR3 CX3CR1 CD4 CCR6 CCL4
3
Show member pathways
13.11 TNF CX3CR1 CD4 CCR6 CCL4 CCL2
4
Show member pathways
12.8 TNF TLR3 NOS2 IFNB1 CCL4 CCL2
5
Show member pathways
12.71 CX3CR1 CD4 CCR6 CCL4 CCL2
6
Show member pathways
12.64 TNF TLR3 IFNB1 CD4 CCL4 CCL2
7
Show member pathways
12.44 TNF NOS2 CD4 CCL2
8
Show member pathways
11.89 TNF CX3CR1 CCR6 CCL4 CCL2
9 11.85 TNF CX3CR1 CD4
10 11.84 TNF IFNB1 CD4 CCL2
11 11.82 TNF NOS2 CCL2
12
Show member pathways
11.81 NOS2 CD4 CCL4
13 11.8 TNF IFNB1 CCL2
14 11.77 SAG RBP3 ARR3
15 11.62 TNF CD4 CCR6
16
Show member pathways
11.58 TNF TLR3 CD4
17 11.49 TNF NOS2 CCR6
18 11.45 TNF CCL4 CCL2
19 11.32 TNF CCL4 CCL2
20 11.29 TNF NOS2 CCL2
21 11.13 TNF IFNB1 CX3CR1 CD4
22 11 CX3CR1 CCL2 ACE
23 10.8 TNF CCL2
24 10.39 TNF IFNB1 IFN1@ CD4

GO Terms for Retinal Vasculitis

Cellular components related to Retinal Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TNF SOD1 RBP3 IFNB1 CCL4 CCL2
2 external side of plasma membrane GO:0009897 9.55 TNF CX3CR1 CD4 CCR6 ACE
3 cell surface GO:0009986 9.43 TNF TLR3 CX3CR1 CD4 CCR6 APOH
4 extracellular space GO:0005615 9.28 TNF TLR3 SOD1 RBP3 IFNB1 CCL4

Biological processes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.14 TLR3 SAG CX3CR1 CD4 CCR6 CCL4
2 cell surface receptor signaling pathway GO:0007166 9.87 SAG IFNB1 CD4 CCL2
3 inflammatory response GO:0006954 9.85 TNF TLR3 NOS2 CCL4 CCL2
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 TNF CD4 CCL4 CCL2
5 cellular response to lipopolysaccharide GO:0071222 9.73 TNF NOS2 CX3CR1 CCL2
6 cell chemotaxis GO:0060326 9.72 CX3CR1 CCR6 CCL2
7 chemotaxis GO:0006935 9.71 CX3CR1 CCR6 CCL4 CCL2
8 response to virus GO:0009615 9.67 TNF TLR3 IFNB1 CCL4
9 positive regulation of cytokine production GO:0001819 9.65 TNF TLR3 SOD1
10 cellular response to interferon-gamma GO:0071346 9.62 TLR3 NOS2 CCL4 CCL2
11 heart contraction GO:0060047 9.58 SOD1 ACE
12 positive regulation of calcium-mediated signaling GO:0050850 9.58 CD4 CCL4
13 G protein-coupled receptor internalization GO:0002031 9.56 SAG ARR3
14 chemokine-mediated signaling pathway GO:0070098 9.56 CX3CR1 CCR6 CCL4 CCL2
15 necroptotic signaling pathway GO:0097527 9.52 TNF TLR3
16 positive regulation of I-kappaB phosphorylation GO:1903721 9.49 TNF CX3CR1
17 humoral immune response GO:0006959 9.46 TNF IFNB1 CCR6 CCL2
18 cytokine-mediated signaling pathway GO:0019221 9.43 TNF NOS2 IFNB1 CD4 CCL4 CCL2
19 immune response GO:0006955 9.17 TNF TLR3 CX3CR1 CD4 CCR6 CCL4

Molecular functions related to Retinal Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IFNB1 CCL4 CCL2
2 opsin binding GO:0002046 8.62 SAG ARR3

Sources for Retinal Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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