MCID: RTN001
MIFTS: 45

Retinal Vasculitis

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Retinal Vasculitis

MalaCards integrated aliases for Retinal Vasculitis:

Name: Retinal Vasculitis 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11563
ICD10 33 H35.06
ICD9CM 35 362.18
MeSH 44 D031300
SNOMED-CT 68 193367006 77628002
UMLS 73 C0152026

Summaries for Retinal Vasculitis

MalaCards based summary : Retinal Vasculitis is related to eales disease and retinal vein occlusion, and has symptoms including eye manifestations An important gene associated with Retinal Vasculitis is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Dendritic Cells Developmental Lineage Pathway. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Retinal vasculitis is inflammation of the vascular branches of the retinal artery, caused either by... more...

Related Diseases for Retinal Vasculitis

Diseases related to Retinal Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 eales disease 31.0 NOS2 SAG SOD1
2 retinal vein occlusion 30.3 APOH CCL2
3 retinal vascular occlusion 29.9 APOH CCL2
4 temporal arteritis 29.6 APOH CCL2
5 multiple sclerosis 27.9 CCL2 IFNB1 NOS2
6 irvan syndrome 11.8
7 retinitis 10.9
8 vasculitis 10.9
9 aneurysm 10.4
10 neuroretinitis 10.4
11 uveitis 10.2
12 degeneration of macula and posterior pole 10.2 CCL2 CX3CR1
13 systemic lupus erythematosus 10.1
14 cataract 10.1
15 lupus erythematosus 10.1
16 choroiditis 10.0
17 secondary progressive multiple sclerosis 10.0 CCL2 IFNB1
18 scleritis 9.9
19 endophthalmitis 9.9
20 ocular hyperemia 9.9 IFNB1 SOD1
21 pneumoconiosis 9.9 CCL2 SOD1
22 borderline leprosy 9.9 APOH NOS2
23 rheumatoid arthritis 9.9
24 arthritis 9.9
25 crohn's disease 9.9
26 lymphoma 9.9
27 mixed connective tissue disease 9.9
28 syphilis 9.9
29 connective tissue disease 9.9
30 chickenpox 9.9
31 anterior uveitis 9.9
32 transient cerebral ischemia 9.9 APOH CCL2
33 severe acute respiratory syndrome 9.9 CCL2 IFNB1
34 japanese encephalitis 9.9 IFNB1 TLR3
35 west nile virus 9.8
36 polyarteritis nodosa, childhood-onset 9.8
37 leukemia 9.8
38 panuveitis 9.8
39 optic neuritis 9.8
40 intermediate uveitis 9.8
41 neuritis 9.8
42 optic nerve disease 9.8
43 melanoma 9.8
44 central retinal vein occlusion 9.8
45 macular retinal edema 9.8
46 retinal artery occlusion 9.8
47 neuropathy 9.8
48 polyarteritis nodosa 9.8
49 acute posterior multifocal placoid pigment epitheliopathy 9.8
50 endotheliitis 9.8

Graphical network of the top 20 diseases related to Retinal Vasculitis:



Diseases related to Retinal Vasculitis

Symptoms & Phenotypes for Retinal Vasculitis

UMLS symptoms related to Retinal Vasculitis:


eye manifestations

GenomeRNAi Phenotypes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 CX3CR1 NOS2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 NOS2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.64 NOS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 NOS2 APOH CX3CR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 CX3CR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.64 CX3CR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.64 CX3CR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.64 NOS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.64 NOS2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.64 NOS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 APOH
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 APOH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.64 CX3CR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 NOS2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 APOH CX3CR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.64 NOS2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.64 NOS2

MGI Mouse Phenotypes related to Retinal Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 SAG SOD1 TLR3 APOH CX3CR1 IFNB1
2 immune system MP:0005387 9.63 NOS2 SOD1 TLR3 CCL2 CX3CR1 IFNB1
3 neoplasm MP:0002006 9.26 NOS2 SOD1 TLR3 IFNB1
4 nervous system MP:0003631 9.1 NOS2 SAG SOD1 TLR3 CX3CR1 IFNB1

Drugs & Therapeutics for Retinal Vasculitis

Drugs for Retinal Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-24-8 5755
3 Antiemetics Phase 4,Not Applicable
4 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2,Not Applicable
5 Antineoplastic Agents, Hormonal Phase 4,Not Applicable
6 Autonomic Agents Phase 4,Not Applicable
7 Gastrointestinal Agents Phase 4,Not Applicable
8 glucocorticoids Phase 4,Not Applicable
9 Hormone Antagonists Phase 4,Phase 2,Not Applicable
10 Hormones Phase 4,Phase 2,Not Applicable
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Not Applicable
12 Methylprednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
13 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2,Not Applicable
14 Neuroprotective Agents Phase 4,Not Applicable
15 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1,Not Applicable
16 Prednisolone acetate Phase 4,Phase 3,Phase 2,Not Applicable
17 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2,Not Applicable
18 Prednisolone phosphate Phase 4,Phase 3,Phase 2,Not Applicable
19 Protective Agents Phase 4,Not Applicable
20 Adrenocorticotropic Hormone Phase 4,Phase 2
21 beta-endorphin Phase 4,Phase 2
22 Melanocyte-Stimulating Hormones Phase 4,Phase 2
23
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
24
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
25 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
26 Dermatologic Agents Phase 3,Phase 2,Not Applicable
27 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
28 Antifungal Agents Phase 3
29 Anti-Infective Agents Phase 3,Phase 1,Phase 2
30 Antiviral Agents Phase 3
31 Calcineurin Inhibitors Phase 3
32 Cyclosporins Phase 3
33 Interferon-alpha Phase 3
34 interferons Phase 3
35 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
36 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
37
Abatacept Approved Phase 2 332348-12-6 10237
38
Methotrexate Approved Phase 2,Not Applicable 1959-05-2, 59-05-2 126941
39
Azathioprine Approved Phase 2 446-86-6 2265
40
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
41
rituximab Approved Phase 2 174722-31-7 10201696
42
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
43
Ustekinumab Approved, Investigational Phase 2 815610-63-0
44
Apremilast Approved, Investigational Phase 1, Phase 2 608141-41-9 11561674
45 tannic acid Approved, Nutraceutical Phase 2
46 Analgesics Phase 2,Phase 1,Not Applicable
47 Analgesics, Non-Narcotic Phase 2,Phase 1,Not Applicable
48 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2,Not Applicable
49 Antibodies Phase 2
50 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
2 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
3 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Completed NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
4 Lucentis (Ranibizumab) for Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab
5 Abatacept in the Treatment of Uveitis Unknown status NCT01279954 Phase 2 Abatacept
6 Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's Disease Completed NCT00664599 Phase 2 Rituximab;Cytotoxic Combination
7 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
8 HAT in Eye Complications of Behcet's Disease Completed NCT00001865 Phase 2 Daclizumab
9 Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease Recruiting NCT02648581 Phase 2 Subcutaneous Ustekinumab
10 ACTH as A Re-emerging theRapy for Uveitis (The ACTHAR Study) Not yet recruiting NCT02931175 Phase 2 ACTH gel
11 Apremilast in the Treatment of Uveitis Terminated NCT00889421 Phase 1, Phase 2 Apremilast
12 Stem Cell Transplantation in Ocular Lesions of Behcet's Disease Terminated NCT00550498 Phase 1
13 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Not Applicable Etanercept, Methotrexate, Prednisolone
14 Biological Markers in Retinal Vasculitis Completed NCT00050492
15 Optical Coherence Tomography (OCT) in Retinal Vasculitis Recruiting NCT01998464
16 Evaluation of Macular Vascular Changes in Behcet's Disease Using Optical Coherence Tomography Angiography Recruiting NCT03264391

Search NIH Clinical Center for Retinal Vasculitis

Cochrane evidence based reviews: retinal vasculitis

Genetic Tests for Retinal Vasculitis

Anatomical Context for Retinal Vasculitis

MalaCards organs/tissues related to Retinal Vasculitis:

41
Eye, T Cells, Endothelial, Testes, Retina, Pituitary, Skin

Publications for Retinal Vasculitis

Articles related to Retinal Vasculitis:

(show top 50) (show all 382)
# Title Authors Year
1
Retinal vasculitis and Eales disease. ( 29599058 )
2018
2
Efficacy of adalimumab and infliximab in recalcitrant retinal vasculitis inadequately responsive to other immunomodulatory therapies. ( 29766375 )
2018
3
Evaluation of efficacy of infliximab for retinal vasculitis and extraocular symptoms in BehAset disease. ( 29582190 )
2018
4
Retinal Vasculitis in Takayasu's Arteritis. ( 29791818 )
2018
5
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). ( 29406987 )
2018
6
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis. ( 29059086 )
2018
7
Hemorrhagic Ischemic Retinal Vasculitis and Alopecia Areata as a Manifestation of HLA-B27. ( 29304269 )
2018
8
THE COLLABORATIVE OCULAR TUBERCULOSIS STUDY (COTS)-1: A Multinational Review of 251 Patients With Tubercular Retinal Vasculitis. ( 29697588 )
2018
9
Vancomycin-associated hemorrhagic occlusive retinal vasculitis: a clinical-pathophysiological analysis. ( 29425799 )
2018
10
Mild Bilateral Hemorrhagic Occlusive Retinal Vasculitis Following Intracameral Vancomycin Administration in Cataract Surgery. ( 29772049 )
2018
11
HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AFTER INTRACAMERAL VANCOMYCIN USE IN CATARACT SURGERY AFTER INTRAVENOUS EXPOSURE. ( 29474222 )
2018
12
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis: Erratum. ( 29782408 )
2018
13
Retinal vasculitis associated with CREST syndrome. ( 29780934 )
2018
14
Macular changes in retinal vasculitis. ( 29480259 )
2018
15
Pathogenesis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) or 'idiopathic retinal arteriolar aneurysms (IRAA)' with macular star. ( 29447942 )
2018
16
A new perspective for analyzing clinical characteristics of idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. ( 29934930 )
2018
17
SjAPgren's Disease Associated with Severe Retinal Vasculitis and/or Necrotizing Scleritis: Two Cases. ( 29452446 )
2018
18
Varicella-zoster virus necrotising retinitis, retinal vasculitis and panuveitis following uncomplicated chickenpox in an immunocompetent child. ( 29622711 )
2018
19
Resolution of arterial aneurysms in idiopathic retinal vasculitis, aneurysms and neuroretinitis: a case report and review of literature. ( 29594790 )
2018
20
Comparison between optical coherence tomography angiography and fluorescein angiography findings in retinal vasculitis. ( 29692926 )
2018
21
Tubercular retinal vasculitis mimicking frosted branch angiitis: a case report. ( 29356903 )
2018
22
Retinal Vasculitis Is Principally a Single-Organ Vasculitis of the Eye. ( 29280823 )
2017
23
Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography. ( 28844053 )
2017
24
Retinal vasculitis associated with cutaneous leukocytoclastic vasculitis. ( 29256164 )
2017
25
Clinical Outcome of Retinal Vasculitis and Predictors for Prognosis of Ischemic Retinal Vasculitis. ( 28263735 )
2017
26
Intracameral Antibiotics in the Shadow of Hemorrhagic Occlusive Retinal Vasculitis. ( 28433122 )
2017
27
Hemorrhagic occlusive retinal vasculitis after inadvertent intraocular perforation with gentamycin injection. ( 28233891 )
2017
28
Ultra-wide imaging in a case of retinal vasculitis with macular star. ( 29054905 )
2017
29
RETINAL VASCULITIS ASSOCIATED WITH NEUROMYELITIS OPTICA. ( 27820753 )
2017
30
Clinical Features and Incidence Rates of Ocular Complications in Patients With Retinal Vasculitis. ( 28501390 )
2017
31
TREATMENT OF IDIOPATHIC RETINAL VASCULITIS, ANEURYSMS, AND NEURORETINITIS (IRVAN) WITH PHOTOCOAGULATION IN COMBINATION WITH SYSTEMIC IMMUNOSUPPRESSION. ( 29261555 )
2017
32
Multimodal Imaging in Retinal Vasculitis. ( 28696172 )
2017
33
Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. ( 28724375 )
2017
34
Acute necrotizing retinal vasculitis as onset of systemic lupus erythematosus: A case report. ( 28079801 )
2017
35
Bilateral Branch Occlusive Retinal Vasculitis Induced by Septic Embo-lism in Endogenous Klebsiella Endo-phthalmitis. ( 28367048 )
2017
36
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
37
A New Complication Associated with the Use of Prophylactic Intracameral Antibiotics: Hemorrhagic Occlusive Retinal Vasculitis. ( 28433121 )
2017
38
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: clinical perspectives. ( 29062224 )
2017
39
Intravitreal bevacizumab in treatment of retinal neovascularization from tuberculous retinal vasculitis. ( 29062788 )
2017
40
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
41
Case of combination therapy to treat lupus retinal vasculitis refractory to steroids. ( 28237161 )
2017
42
Early anti-VEGF treatment for hemorrhagic occlusive retinal vasculitis as a complication of cataract surgery. ( 29212481 )
2017
43
Characteristics and visual outcome of refractory retinal vasculitis associated with antineutrophil cytoplasm antibody-associated vasculitides. ( 29258731 )
2017
44
Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease. ( 28937479 )
2017
45
Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis. ( 28810044 )
2017
46
Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: Clinical Characteristics of 36 Eyes. ( 28110950 )
2017
47
Characterization of isolated retinal vasculitis. Analysis of a cohort from a single center and literature review. ( 28137481 )
2017
48
Ultra-widefield fundus fluorescein angiography in the diagnosis and management of retinal vasculitis. ( 28574499 )
2017
49
UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS. ( 28816862 )
2017
50
New imaging techniques in retinal vasculitis. ( 28687121 )
2017

Variations for Retinal Vasculitis

Expression for Retinal Vasculitis

Search GEO for disease gene expression data for Retinal Vasculitis.

Pathways for Retinal Vasculitis

GO Terms for Retinal Vasculitis

Biological processes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.71 CCL2 NOS2 TLR3
2 cell surface receptor signaling pathway GO:0007166 9.67 CCL2 IFNB1 SAG
3 chemokine-mediated signaling pathway GO:0070098 9.55 CCL2 CX3CR1
4 cellular response to drug GO:0035690 9.52 NOS2 TLR3
5 humoral immune response GO:0006959 9.51 CCL2 IFNB1
6 response to exogenous dsRNA GO:0043330 9.48 IFNB1 TLR3
7 response to bacterium GO:0009617 9.46 CCL2 NOS2
8 positive regulation of cytokine production GO:0001819 9.43 SOD1 TLR3
9 cellular response to lipopolysaccharide GO:0071222 9.43 CCL2 CX3CR1 NOS2
10 superoxide metabolic process GO:0006801 9.4 NOS2 SOD1
11 cellular response to exogenous dsRNA GO:0071360 9.37 IFNB1 TLR3
12 cellular response to interferon-beta GO:0035458 9.32 IFNB1 TLR3
13 macrophage chemotaxis GO:0048246 9.16 CCL2 CX3CR1
14 cellular response to interferon-gamma GO:0071346 9.13 CCL2 NOS2 TLR3
15 cytokine-mediated signaling pathway GO:0019221 8.92 CCL2 CX3CR1 IFNB1 NOS2

Sources for Retinal Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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