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MCID: RTN022
MIFTS: 54

Retinal Vein Occlusion

Categories: Cardiovascular diseases, Eye diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Retinal Vein Occlusion

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MalaCards integrated aliases for Retinal Vein Occlusion:

Name: Retinal Vein Occlusion 38 12 55 44 15 73
Occlusion, of Retinal Vein 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Cardiovascular diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:1727
MeSH 44 D012170
NCIt 50 C34981
SNOMED-CT 68 46085004
UMLS 73 C0035328
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Summaries for Retinal Vein Occlusion

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MalaCards based summary : Retinal Vein Occlusion, also known as occlusion, of retinal vein, is related to central retinal vein occlusion and macular retinal edema. An important gene associated with Retinal Vein Occlusion is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Formation of Fibrin Clot (Clotting Cascade). The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

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Related Diseases for Retinal Vein Occlusion

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Diseases in the Retinal Vein Occlusion family:

Central Retinal Vein Occlusion

Diseases related to Retinal Vein Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 315)
# Related Disease Score Top Affiliating Genes
1 central retinal vein occlusion 33.1 APOH F2 F5 IL6 LOXL1 MTHFR
2 macular retinal edema 31.8 CCL2 IL6 VEGFA
3 macular dystrophy, dominant cystoid 31.1 SERPINF1 VEGFA
4 microvascular complications of diabetes 5 30.5 SERPINE1 SERPINF1 VEGFA
5 branch retinal artery occlusion 30.5 APOH F2 MTHFR SERPINC1
6 ischemic optic neuropathy 30.3 APOH F2 F5 MTHFR SERPINC1
7 nonarteritic anterior ischemic optic neuropathy 30.3 F2 F5 MTHFR SERPINC1
8 retinal vasculitis 30.3 APOH CCL2
9 diabetic macular edema 30.2 CCL2 IL6 SERPINF1 VEGFA
10 eclampsia 30.2 F2 MTHFR SERPINC1
11 purpura 30.2 APOH F2 IL6 SERPINC1
12 temporal arteritis 30.2 APOH CCL2 IL6
13 thrombophilia 30.2 APOH F2 F5 MTHFR SERPINC1 SERPINE1
14 protein s deficiency 30.2 APOH F2 F5 MTHFR SERPINC1
15 antiphospholipid syndrome 30.2 APOH F2 F5 MTHFR SERPINC1
16 factor xii deficiency 30.2 APOH F5 SERPINC1
17 thrombocytosis 30.2 F2 IL6 SERPINC1
18 arteritic anterior ischemic optic neuropathy 30.0 F2 F5 MTHFR
19 retinal vascular disease 30.0 CCL2 MTHFR SERPINF1 VEGFA
20 retinal artery occlusion 30.0 APOH F2 F5 IL6 MTHFR SERPINC1
21 thrombosis 29.9 APOH F2 F5 MTHFR SERPINC1 SERPINE1
22 sneddon syndrome 29.9 APOH F2 SERPINC1
23 macular holes 29.9 CCL2 SERPINF1 VEGFA
24 coronary artery anomaly 29.9 F2 F5 SERPINE1
25 protein c deficiency 29.8 F2 F5 MTHFR SERPINC1
26 homocysteinemia 29.8 F2 F5 MTHFR SERPINC1
27 antithrombin iii deficiency 29.7 APOH F2 F5 MTHFR SERPINC1
28 thrombophilia due to activated protein c resistance 29.6 APOH F2 F5 MTHFR SERPINC1 SERPINE1
29 thrombophilia due to thrombin defect 29.6 APOH F2 F5 MTHFR SERPINC1 SERPINE1
30 cerebrovascular disease 29.6 F2 F5 IL6 MTHFR SERPINE1
31 heart disease 29.4 F2 IL6 MTHFR SERPINC1 SERPINE1 VEGFA
32 arteries, anomalies of 29.4 CCL2 IL6 SERPINC1 SERPINE1 VEGFA
33 pre-eclampsia 29.3 APOH F2 F5 IL6 MTHFR SERPINC1
34 hellp syndrome 29.2 APOH F2 F5 IL6 MTHFR SERPINC1
35 retinal vascular occlusion 29.2 APOH CCL2 F2 F5 MTHFR SERPINC1
36 myocardial infarction 29.2 CCL2 F2 F5 IL6 ITGA2 MTHFR
37 vascular disease 29.2 APOH CCL2 F2 F5 IL6 MTHFR
38 partial of retinal vein occlusion 12.4
39 ischemia 10.5
40 neovascular glaucoma 10.4
41 retinal detachment 10.4
42 optic nerve disease 10.3
43 neuropathy 10.3
44 paracetamol poisoning 10.3 F2 F5
45 hemifacial spasm 10.3 MTHFR VEGFA
46 mesenteric vascular occlusion 10.2 F2 MTHFR
47 may-thurner syndrome 10.2 APOH F5
48 retinal ischemia 10.2
49 open-angle glaucoma 10.2
50 central retinal artery occlusion 10.2

Graphical network of the top 20 diseases related to Retinal Vein Occlusion:



Diseases related to Retinal Vein Occlusion
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Symptoms & Phenotypes for Retinal Vein Occlusion

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MGI Mouse Phenotypes related to Retinal Vein Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.06 F2 F5 IL6 LOXL1 SERPINC1 SERPINE1
2 homeostasis/metabolism MP:0005376 10.06 APOH F2 F5 IL6 ITGA2 LOXL1
3 hematopoietic system MP:0005397 9.97 F2 IL6 ITGA2 SERPINC1 SERPINE1 SERPINF1
4 integument MP:0010771 9.86 F2 F5 IL6 ITGA2 LOXL1 MTHFR
5 liver/biliary system MP:0005370 9.63 F5 IL6 MTHFR SERPINC1 SERPINE1 VEGFA
6 nervous system MP:0003631 9.61 F2 F5 IL6 LOXL1 MTHFR SERPINC1
7 reproductive system MP:0005389 9.17 F2 IL6 LOXL1 MTHFR SERPINC1 SERPINF1
Sources

Drugs & Therapeutics for Retinal Vein Occlusion

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Drugs for Retinal Vein Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 154)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 216974-75-3
2
Ranibizumab Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 347396-82-1 459903
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 1177-87-3
5
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 124-94-7 31307
6
Verteporfin Approved, Investigational Phase 4 129497-78-5
7
Histidine Approved, Nutraceutical Phase 4 71-00-1 6274
8
Lactitol Investigational Phase 4 585-86-4 3871
9 Endothelial Growth Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Mitogens Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Angiogenesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
13 Angiogenesis Modulating Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 BB 1101 Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
15
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
17 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
19 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
20 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
21 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
22 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
27 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 triamcinolone acetonide Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Triamcinolone hexacetonide Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Triamcinolone diacetate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
31 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Dexamethasone 21-phosphate Phase 4
33 Mitomycins Phase 4
34 Dermatologic Agents Phase 4,Phase 1,Phase 2
35 Photosensitizing Agents Phase 4
36
Eplerenone Approved Phase 2, Phase 3 107724-20-9 443872 150310
37
Spironolactone Approved Phase 2, Phase 3 52-01-7, 1952-01-7 5833
38
Povidone-iodine Approved Phase 3,Not Applicable 25655-41-8
39
Betamethasone Approved, Vet_approved Phase 2, Phase 3 378-44-9 9782
40
Nicotinamide Approved, Investigational Phase 2, Phase 3,Phase 3 98-92-0 936
41
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
42
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
43
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
44
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
45
Dabrafenib Approved, Investigational Phase 3,Phase 2 1195765-45-7 44462760 44516822
46
Trametinib Approved Phase 3,Phase 2 871700-17-3 11707110
47
Povidone Approved Phase 3 9003-39-8
48
Iodine Approved, Investigational Phase 3 7553-56-2 807
49
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
50
Dalteparin Approved Phase 3 9005-49-6

Interventional clinical trials:

(show top 50) (show all 236)
# Name Status NCT ID Phase Drugs
1 Study of Intravitreal Aflibercept Injection for Persistent CRVO-associated Macular Edema Despite Prior Anti-VEGF Therapy Unknown status NCT01857544 Phase 4 Aflibercept
2 Evaluation of the "Treat-and-extend" Scheme in Patients With Retinal Vein Occlusion (RVO) With and Without LASER Treatment of Ischaemic Retinal Areas Unknown status NCT02522897 Phase 4 Ranibizumab
3 Retinal Sensitivity in BRVO After Anti-VEGF Therapy Unknown status NCT02527733 Phase 4 Ranibizumab;Ranibizumab and laser
4 Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion Unknown status NCT01827722 Phase 4 Ozurdex;Ranibizumab;Combination Ozurdex with Ranibizumab PRN
5 Treatment of Bevacizumab and Triamcinolone in Treatment or Macular Edema Secondary to CRVO Unknown status NCT00566761 Phase 4 bevacizumab and triamcinolone
6 Comparing Injection Frequency Between Aflibercept and Ranibizumab in Patients With CRVO With a Treat& Extend Regimen Unknown status NCT02274259 Phase 4 Aflibercept;Ranibizumab
7 Ranibizumab in Patients With Branch Retinal Vein Occlusion Completed NCT01027481 Phase 4 Lucentis
8 Hemodilution Versus Ranibizumab in Early-onset Central Retinal Vein Occlusion Completed NCT01448018 Phase 4 ranibizumab
9 Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion Completed NCT00406107 Phase 4 pegaptanib sodium (Macugen)
10 Single Site, Masked, Randomized, Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion Completed NCT01085734 Phase 4 Avastin;Osurdex;Avastin
11 Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion Completed NCT01710839 Phase 4 0.5mg Ranibizumab
12 NEWTON: Aflibercept Injection for Previously Treated Macular Edema Associated With Central Retinal Vein Occlusions Completed NCT01870427 Phase 4 Aflibercept (2.0 mg)
13 Safety and Efficacy Study of Ozurdex® Compared to Lucentis® in Patients With Branch Retinal Vein Occlusion Completed NCT01427751 Phase 4 dexamethasone intravitreal implant
14 A Study Evaluating Dosing Regimens for Treatment With Intravitreal Ranibizumab Injections in Subjects With Macular Edema Following Retinal Vein Occlusion Completed NCT01277302 Phase 4 Ranibizumab
15 A Safety and Efficacy Study of OZURDEX® in Macular Edema Associated With Branch Retinal Vein Occlusion Completed NCT01903720 Phase 4 dexamethasone implant
16 Extension Study to Compare Long-term Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With RVO Completed NCT01580020 Phase 4 Dexamethasone
17 Dexamethasone-implant for the Treatment of RVO Completed NCT01767545 Phase 4 Dexamethasone implant;Bevacizumab
18 Efficacy and Safety of Lucentis® (Ranibizumab Intravitreal Injections) in Chilean Patients With Diabetic Macular Edema. Completed NCT02140411 Phase 4 Ranibizumab Intravitreal injections
19 Peripheral and Macular Retinal Vascular Perfusion and Leakage in DME and RVO Completed NCT02503540 Phase 4 Aflibercept
20 Morphological and Functional Retinal Changes Following Retinal Photocoagulation Completed NCT00682240 Phase 4
21 Intraocular Bevacizumab (Avastin) for Rubeosis Iridis Completed NCT00557232 Phase 4 bevacizumab
22 Intravitreous Ranibizumab as Adjunctive Treatment for Trabeculectomy in Neovascular Glaucoma Completed NCT01922154 Phase 4 intravitreal ranibizumab
23 Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion Recruiting NCT03405376 Phase 4 Intravitreal aflibercept injection
24 Evaluation of the Usefulness of a PRN Regimen Using Ranibizumab for Macular Edema Due to Branch Retinal Vein Occlusion Recruiting NCT02478515 Phase 4 Ranibizumab
25 Cohort Study of the Clinical Course of Macular Diseases in Kagawa Recruiting NCT02321267 Phase 4 ranibizumab, aflibercept, pegaptanib, verteporphin
26 Ranibizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion in Patients With Fair Vision Active, not recruiting NCT01795209 Phase 4 Ranibizumab
27 Evaluation of a Treat and Extend Regimen of Intravitreal Aflibercept for Macular Edema Secondary to CRVO Active, not recruiting NCT02800642 Phase 4 Eylea (Aflibercept, VEGF Trap-Eye, BAY86-5321)
28 Study to Show a Superior Benefit in Terms of Reduction of Ranibizumab Injections in Patients Receiving Ranibizumab Plus Laser Photocoagulation Combination Therapy Without Loss of Efficacy and Safety Active, not recruiting NCT02953938 Phase 4
29 Continuation of Previous Study to Gather More Data on Effect of Macugen on the Corneal Endothelium Active, not recruiting NCT01573572 Phase 4 pegaptanib sodium injection
30 Eylea and Lucentis for Macular Edema in Branch Retinal Vein Occlusion Not yet recruiting NCT03709745 Phase 4 Aflibercept Injection [Eylea];Ranibizumab Injection [Lucentis]
31 Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept Not yet recruiting NCT03056079 Phase 4 Intravitreal aflibercept
32 Cytokine and Visual Outcome Variations in Eyes Receiving Ranibizumab Not yet recruiting NCT03056092 Phase 4 Intravitreal ranibizumab
33 Combination OZURDEX® & LUCENTIS® vs. OZURDEX® Monotherapy in Incomplete-Responders With Diabetic Macular Edema Terminated NCT02684084 Phase 4 Ozurdex;Lucentis
34 Comparing the Effectiveness and Costs of Bevacizumab to Ranibizumab in Patients With Retinal Vein Occlusions (BRVO) Unknown status NCT01635803 Phase 2, Phase 3 Bevacizumab;Ranibizumab
35 Comparison of Intravitreal Ranibizumab and Macular Laser Photocoagulation for ME Following Branch Retinal Vein Occlusion (BRVO) Unknown status NCT01189526 Phase 3 Ranibizumab
36 Atorvastatin for the Treatment of Retinal Vein Occlusion Unknown status NCT00517257 Phase 3 Atorvastatin;Placebo
37 A Study of the Beneficial Effects of Eplerenone on Central Serous Chorioretinopathy Unknown status NCT02215330 Phase 2, Phase 3 Eplerenone;Maltodextrin
38 Effect of Avastin in Juxtafoveal Telangiectasias Unknown status NCT00406380 Phase 3 Bevacizumab
39 Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy Unknown status NCT02769169 Phase 2, Phase 3 Lucentis® (Raibizumab) double-dose;Lucentis® (Raibizumab) regular-dose
40 Efficacy and Safety of Ranibizumab With or Without Laser in Comparison to Laser in Branch Retinal Vein Occlusion Completed NCT01599650 Phase 3 Ranibizumab
41 Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion Completed NCT02033031 Phase 3 Lucentis intravitreal injection;Avastin intravitreal injection
42 Ozurdex for Retinal Vein Occlusion Study (ORVO Study) Completed NCT01790685 Phase 2, Phase 3 dexamethasone implant
43 Efficacy and Safety of Ranibizumab in Japanese Patients With Retinal Vein Occlusion Completed NCT01377597 Phase 3 ranibizumab
44 Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Central Retinal Vein Occlusion (CRVO) Completed NCT01976312 Phase 3 Ranibizumab 0.5 mg
45 Vascular Endothelial Growth Factor (VEGF) Trap-Eye: Investigation of Efficacy and Safety in Central Retinal Vein Occlusion (CRVO) Completed NCT01012973 Phase 3
46 Safety and Effectiveness of Bevacizumab Intravitreal Injections in the Treatment of Macular Edema Secondary to Retinal Vein Occlusion Completed NCT00970957 Phase 3 Avastin Intravitreal Injection;Sham Avastin Intravitreal Injection
47 Combined Triple Procedure in Retinal Vein Occlusion (RVO) Completed NCT00805064 Phase 3 triamcinolone and bevacizumab
48 Bevacizumab for Central Retinal Vein Occlusion Study Completed NCT00906685 Phase 3 bevacizumab;Sham bevacizumab injection
49 Extended Follow-up of Patients With Macular Edema Due to Retinal Vein Occlusion Completed NCT01198327 Phase 3 ranibizumab
50 The Standard Care vs. COrticosteroid for REtinal Vein Occlusion (SCORE) Study Completed NCT00105027 Phase 3 intravitreal triamcinolone injection;intravitreal triamcinolone injection

Search NIH Clinical Center for Retinal Vein Occlusion

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Vein Occlusion cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells for retinopathy
Embryonic/Adult Cultured Cells Related to Retinal Vein Occlusion:
Bone marrow-derived hematopoietic CD34+ progenitors PMIDs: 22247454
Bone marrow-derived hematopoietic stem cells (family) PMIDs: 22247454

Cochrane evidence based reviews: retinal vein occlusion

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Genetic Tests for Retinal Vein Occlusion

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Anatomical Context for Retinal Vein Occlusion

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MalaCards organs/tissues related to Retinal Vein Occlusion:

41
Eye, Endothelial, Bone, Retina, Bone Marrow, Heart, Myeloid
Sources

Publications for Retinal Vein Occlusion

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Articles related to Retinal Vein Occlusion:

(show top 50) (show all 1960)
# Title Authors Year
1
Malignant optic glioma masked by suspected optic neuritis and central retinal vein occlusion. ( 30450148 )
2019
2
Central retinal vein occlusion in temporal arteritis: red sign or red herring? ( 29361164 )
2018
3
Effects of Dexamethasone Implant on Multifocal Electroretinography in Central Retinal Vein Occlusion. ( 29403585 )
2018
4
YC-1 Inhibits VEGF and Inflammatory Mediators Expression on Experimental Central Retinal Vein Occlusion in Rhesus Monkey. ( 29364731 )
2018
5
Predicting the visual acuity for retinal vein occlusion after ranibizumab therapy with an original ranking for macular microstructure. ( 29399095 )
2018
6
Incidence of retinal vein occlusion in open-angle glaucoma: a nationwide, population-based study using the Korean Health Insurance Review and Assessment Database. ( 29360215 )
2018
7
A 5-Year Follow-Up Study of the Treatment of Macular Edema Due to Retinal Vein Occlusion Using Dexamethasone Intravitreal Implants. ( 29708803 )
2018
8
Retinal vein occlusion associated with combined hormonal contraceptive vaginal ring use. ( 29862193 )
2018
9
TOPICAL DORZOLAMIDE-TIMOLOL WITH INTRAVITREOUS ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR FOR RETINAL VEIN OCCLUSION: A PILOT STUDY. ( 29864044 )
2018
10
USE OF THE ISCHEMIC INDEX ON WIDEFIELD FLUORESCEIN ANGIOGRAPHY TO CHARACTERIZE A CENTRAL RETINAL VEIN OCCLUSION AS ISCHEMIC OR NONISCHEMIC. ( 29474305 )
2018
11
Comparing Cytokine Kinetics between Ranibizumab and Aflibercept in Central Retinal Vein Occlusion with Macular Edema. ( 29804112 )
2018
12
Bevacizumab versus Dexamethasone Implant Followed by Bevacizumab for the Treatment of Macula Edema Associated with Branch Retinal Vein Occlusion. ( 29376223 )
2018
13
Cardiovascular risk factors in patients with combined central retinal vein occlusion and cilioretinal artery occlusion: Case report. ( 29505511 )
2018
14
Comparison of ranibizumab versus dexamethasone for macular oedema following retinal vein occlusion: 1-year results of the COMRADE extension study. ( 29855153 )
2018
15
Real-Life Clinical Effectiveness of RazumabAr (the World's First Biosimilar of Ranibizumab) in Retinal Vein Occlusion: A Subgroup Analysis of the Pooled Retrospective RE-ENACT Study. ( 29945143 )
2018
16
Relationship between Optical Intensity on Optical Coherence Tomography and Retinal Ischemia in Branch Retinal Vein Occlusion. ( 29942024 )
2018
17
Sex-specific age threshold for increased risk of retinal vein occlusion in Koreans. ( 29787945 )
2018
18
Elevated lipocalin-2 level in aqueous humor of patients with central retinal vein occlusion. ( 29572586 )
2018
19
The efficacy of intravitreal dexamethasone implant as the first-line treatment for retinal vein occlusion-related macular edema in a real-life scenario. ( 29785994 )
2018
20
INJECTION FREQUENCY OF AFLIBERCEPT VERSUS RANIBIZUMAB IN A TREAT-AND-EXTEND REGIMEN FOR CENTRAL RETINAL VEIN OCCLUSION: A Randomized Clinical Trial. ( 29624543 )
2018
21
Effect of oral tranexamic acid on macular edema associated with retinal vein occlusion or diabetes. ( 29339919 )
2018
22
The short-term efficacy of intravitreal ranibizumab, aflibercept and dexamethasone implant in the treatment of macular edema due to non-ischemic central retinal vein occlusion. ( 29550932 )
2018
23
Commentary on "Intravitreal dexamethasone implant for management of treatment-naA^ve retinal vein occlusion". ( 29941772 )
2018
24
Safety and efficacy of dexamethasone intravitreal implant for treatment of macular edema secondary to retinal vein occlusion in Chinese patients: randomized, sham-controlled, multicenter study. ( 29399708 )
2018
25
Morphological Implications of Vascular Structures Not Visualized on Optical Coherence Tomography Angiography in Retinal Vein Occlusion. ( 29927465 )
2018
26
Sequential Observations of Conversion from Nonischemic to Ischemic Central Retinal Vein Occlusion Using Optical Coherence Tomography Angiography. ( 29850324 )
2018
27
Real-life clinical data for dexamethasone and ranibizumab in the treatment of branch or central retinal vein occlusion over a period of six months. ( 29185099 )
2018
28
Risk of Retinal Vein Occlusion in Patients With End-Stage Renal Disease: A 12-Year, Retrospective, Nationwide Cohort Study in South Korea. ( 29302692 )
2018
29
Intravitreal dexamethasone implant versus triamcinolone acetonide for macular oedema of central retinal vein occlusion: quantifying efficacy and safety. ( 29632703 )
2018
30
Genetic Background of a Recurrent Unusual Combined Form of Retinal Vein Occlusion: A Case Report. ( 29805379 )
2018
31
Aflibercept Versus Bevacizumab and/or Ranibizumab for Recurrent Macular Edema Secondary to Central Retinal Vein Occlusion. ( 29447089 )
2018
32
Comment on "Evaluation of hyperreflective foci as a prognostic factor of visual outcome in retinal vein occlusion". ( 29862195 )
2018
33
Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion. ( 29788006 )
2018
34
Optical coherence tomography findings as a predictor of clinical course in patients with branch retinal vein occlusion treated with ranibizumab. ( 29924853 )
2018
35
Long-term visual outcome and its predictors in macular oedema secondary to retinal vein occlusion treated with dexamethasone implant. ( 29891733 )
2018
36
Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion. ( 29860457 )
2018
37
Correlation between ischemic index of retinal vein occlusion and oxygen saturation in retinal vessels. ( 29366614 )
2018
38
Swept-Source OCT Angiographic Imaging of a Central Retinal Vein Occlusion During Pregnancy. ( 29554389 )
2018
39
Anomalous coagulation factors in non-arteritic anterior ischemic optic neuropathy with central retinal vein occlusion: A case report. ( 29642215 )
2018
40
Safety and long-term efficacy of repeated dexamethasone intravitreal implants for the treatment of cystoid macular edema secondary to retinal vein occlusion with or without a switch to anti-VEGF agents: a 3-year experience. ( 29855706 )
2018
41
Correlation between macular ganglion cell-inner plexiform layer thickness and visual acuity after resolution of the macular edema secondary to central retinal vein occlusion. ( 29487816 )
2018
42
Impact of Early Anatomical and Functional Responses to Bevacizumab in Macular Edema Secondary to Branch Retinal Vein Occlusion. ( 29393235 )
2018
43
Pre-treatment clinical features in central retinal vein occlusion that predict visual outcome following intravitreal ranibizumab. ( 29426292 )
2018
44
Combined central retinal vein occlusion and branch retinal artery occlusion. ( 30451204 )
2018
45
CENTRAL RETINAL VEIN OCCLUSION IN YOUNG INDIVIDUALS: A Comparison of Risk Factors and Clinical Outcomes. ( 30085977 )
2018
46
Extended Injection Intervals after Switching from Ranibizumab to Aflibercept in Macular Edema due to Central Retinal Vein Occlusion. ( 30116635 )
2018
47
Central retinal vein occlusion revealing celiac disease: The first report of two cases from India. ( 30127151 )
2018
48
Ocriplasmin in the Treatment of Vitreomacular Traction in a Patient with Central Retinal Vein Occlusion: A Case Report. ( 30140222 )
2018
49
Chorioretinal Shunt Vessel in Eyes with Central Retinal Vein Occlusion after Radial Optic Neurotomy. ( 30143093 )
2018
50
Combined bilateral ophthalmic artery occlusion & central retinal vein occlusion from presumed giant cell arteritis. ( 30148234 )
2018
Sources

Variations for Retinal Vein Occlusion

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Expression for Retinal Vein Occlusion

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Search GEO for disease gene expression data for Retinal Vein Occlusion.
Sources

Pathways for Retinal Vein Occlusion

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Pathways related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.88 APOH F2 F5 ITGA2 SERPINC1 SERPINE1
2
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.82 F2 F5 SERPINC1 SERPINE1
3
Interleukin-4 and 13 signaling 66
11.67 CCL2 IL6 VEGFA
4
Complement and coagulation cascades 1 37
11.6 F2 F5 SERPINC1 SERPINE1
5
HIF-1 signaling pathway 37
11.58 IL6 SERPINE1 VEGFA
6
Rheumatoid arthritis 37
11.5 CCL2 IL6 VEGFA
7
Selenium Micronutrient Network 1
Show member pathways
 11.36 CCL2 F2 IL6 MTHFR SERPINE1
8
AGE-RAGE signaling pathway in diabetic complications 37
11.25 CCL2 IL6 SERPINE1 VEGFA
9
Glypican 1 network 1
10.93 SERPINC1 VEGFA
10
IL1 and megakaryocytes in obesity 1
10.89 CCL2 F2
11
Immune response_Oncostatin M signaling via JAK-Stat in human cells 22
10.76 CCL2 VEGFA
12
Warfarin Pathway, Pharmacodynamics 61
10.63 F2 VKORC1
Sources

GO Terms for Retinal Vein Occlusion

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Cellular components related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 APOH CCL2 F2 F5 IL6 LOXL1
2 endoplasmic reticulum lumen GO:0005788 9.62 F2 F5 IL6 SERPINC1
3 collagen-containing extracellular matrix GO:0062023 9.55 APOH LOXL1 SERPINC1 SERPINE1 SERPINF1
4 platelet alpha granule lumen GO:0031093 9.43 F5 SERPINE1 VEGFA
5 extracellular space GO:0005615 9.32 APOH CCL2 F2 F5 IL6 LOXL1

Biological processes related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.77 ITGA2 MTHFR VEGFA
2 regulation of signaling receptor activity GO:0010469 9.77 CCL2 F2 IL6 SERPINE1 VEGFA
3 cellular response to lipopolysaccharide GO:0071222 9.75 CCL2 IL6 SERPINE1
4 cellular protein metabolic process GO:0044267 9.73 F2 F5 IL6 SERPINC1
5 regulation of cell shape GO:0008360 9.71 CCL2 F2 VEGFA
6 negative regulation of endopeptidase activity GO:0010951 9.7 SERPINC1 SERPINE1 SERPINF1
7 platelet degranulation GO:0002576 9.62 APOH F5 SERPINE1 VEGFA
8 positive regulation of JAK-STAT cascade GO:0046427 9.58 F2 IL6
9 hemostasis GO:0007599 9.58 F2 F5 SERPINC1
10 positive regulation of collagen biosynthetic process GO:0032967 9.57 F2 ITGA2
11 fibrinolysis GO:0042730 9.56 F2 SERPINE1
12 negative regulation of endothelial cell migration GO:0010596 9.55 APOH SERPINF1
13 blood coagulation GO:0007596 9.55 F2 F5 ITGA2 SERPINC1 VKORC1
14 blood coagulation, intrinsic pathway GO:0007597 9.51 APOH F2
15 negative regulation of blood coagulation GO:0030195 9.49 APOH SERPINE1
16 positive regulation of leukocyte migration GO:0002687 9.48 ITGA2 VEGFA
17 positive regulation of positive chemotaxis GO:0050927 9.46 ITGA2 VEGFA
18 positive regulation of blood coagulation GO:0030194 9.43 APOH F2 SERPINE1
19 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
20 regulation of blood coagulation GO:0030193 8.92 APOH F2 SERPINC1 VKORC1

Molecular functions related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 F2 IL6 VEGFA
2 serine-type endopeptidase inhibitor activity GO:0004867 9.13 SERPINC1 SERPINE1 SERPINF1
3 heparin binding GO:0008201 8.92 APOH F2 SERPINC1 VEGFA
Sources

Sources for Retinal Vein Occlusion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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