MCID: RTR001
MIFTS: 40

Retrograde Amnesia

Categories: Mental diseases
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Aliases & Classifications for Retrograde Amnesia

MalaCards integrated aliases for Retrograde Amnesia:

Name: Retrograde Amnesia 11 75 14 71 31
Amnesia, Retrograde 75 43

Classifications:



External Ids:

Disease Ontology 11 DOID:4543
MeSH 43 D000648
NCIt 49 C34372
SNOMED-CT 68 51921000
ICD10 31 R41.2
UMLS 71 C0002624

Summaries for Retrograde Amnesia

Disease Ontology: 11 An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection.

MalaCards based summary: Retrograde Amnesia, also known as amnesia, retrograde, is related to anterograde amnesia and amnestic disorder, and has symptoms including forgetful and memory loss. An important gene associated with Retrograde Amnesia is NPTN (Neuroplastin), and among its related pathways/superpathways are Signal Transduction and CREB Pathway. Affiliated tissues include temporal lobe, amygdala and brain, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: 75 In neurology, retrograde amnesia (RA) is a loss of memory-access to events that occurred or information... more...

Related Diseases for Retrograde Amnesia

Diseases related to Retrograde Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 anterograde amnesia 31.5 LGI1 HTR1A FOS EGR1 CA4 BDNF
2 amnestic disorder 31.4 LGI1 HTR1A GRIN2B GRIN2A GRIA1 FOS
3 transient global amnesia 30.9 LGI1 CA4
4 limbic encephalitis 30.3 LGI1 GRIN2B GRIA1
5 dissociative amnesia 30.3 LGI1 CRH CA4 BDNF
6 temporal lobe epilepsy 30.2 LGI1 HTR1A GRIN2B BDNF
7 premature ovarian failure 7 29.9 POMC CRH
8 status epilepticus 29.5 LGI1 GRIN2B GRIA2 GRIA1 FOS BDNF
9 endogenous depression 29.1 SLC6A4 POMC HTR1A CRH CREB1 BDNF
10 major depressive disorder 29.0 SLC6A4 POMC HTR1A GRIA1 FOS CRH
11 alcohol dependence 28.8 SLC6A4 POMC HTR1A GRIN2B GRIN2A CRH
12 alzheimer disease, familial, 1 28.0 SLC6A4 HTR1A GRIN2B GRIN2A GRIA2 GRIA1
13 visual epilepsy 10.4
14 encephalitis 10.4
15 developmental and epileptic encephalopathy 30 10.3 POMC FOS
16 wernicke-korsakoff syndrome 10.3
17 dementia 10.2
18 traumatic brain injury 10.2
19 von economo's disease 10.2 LGI1 FOS
20 carotid artery occlusion 10.2 GRIN2B FOS BDNF
21 occlusion precerebral artery 10.2 GRIN2B FOS BDNF
22 amelogenesis imperfecta, type ig 10.2 FOS CREB1 BDNF
23 high pressure neurological syndrome 10.2 GRIN2B GRIN2A
24 flying phobia 10.2 POMC HTR1A GRIA1
25 motion sickness 10.2 POMC HTR1A FOS
26 cascade stomach 10.2 SLC6A4 HTR1A
27 amphetamine abuse 10.2 SLC6A4 ARC
28 huntington disease 10.2
29 viral encephalitis 10.2
30 herpes simplex encephalitis 10.2
31 cranial nerve disease 10.2 POMC LGI1 BDNF
32 drug psychosis 10.1 LGI1 HTR1A
33 auditory agnosia 10.1 LGI1 GRIN2A
34 inhibited male orgasm 10.1 SLC6A4 HTR1A
35 cyclothymic disorder 10.1 SLC6A4 HTR1A BDNF
36 drug-induced mental disorder 10.1 LGI1 HTR1A
37 morphine dependence 10.1 GRIN2B GRIA1 FOS CREB1
38 premature ejaculation 10.1 SLC6A4 HTR1A BDNF
39 cannabis abuse 10.1 SLC6A4 HTR1A BDNF
40 bipolar i disorder 10.1 SLC6A4 HTR1A BDNF
41 paranoid schizophrenia 10.1 SLC6A4 HTR1A BDNF
42 intermittent explosive disorder 10.1 SLC6A4 HTR1A
43 lingual-facial-buccal dyskinesia 10.1 LGI1 GRIN2B
44 bruxism 10.1 SLC6A4 HTR1A BDNF
45 kleptomania 10.1 SLC6A4 HTR1A GRIN2B
46 psychosexual disorder 10.1 SLC6A4 HTR1A
47 ocular motor apraxia 10.1
48 mild cognitive impairment 10.1
49 familial adult myoclonic epilepsy 10.1
50 hypokalemia 10.1

Graphical network of the top 20 diseases related to Retrograde Amnesia:



Diseases related to Retrograde Amnesia

Symptoms & Phenotypes for Retrograde Amnesia

UMLS symptoms related to Retrograde Amnesia:


forgetful; memory loss

GenomeRNAi Phenotypes related to Retrograde Amnesia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.14 ARC BDNF CA4 CREB1 CRH EGR1
2 no effect GR00402-S-2 10.14 BDNF CA4 CCDC177 CREB1 CRH EGR1

MGI Mouse Phenotypes related to Retrograde Amnesia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.2 ARC BDNF CREB1 CRH EGR1 FOS
2 homeostasis/metabolism MP:0005376 10.1 BDNF CA4 CREB1 CRH EGR1 FOS
3 growth/size/body region MP:0005378 10 ARC BDNF CA4 CREB1 CRH EGR1
4 no phenotypic analysis MP:0003012 9.97 ARC BDNF CRH GRIA1 GRIA2 GRIN2B
5 behavior/neurological MP:0005386 9.86 ARC BDNF CA4 CREB1 CRH EGR1
6 integument MP:0010771 9.36 BDNF CRH EGR1 FOS GRIA1 GRIA2

Drugs & Therapeutics for Retrograde Amnesia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Validation of the German Short Version of the Autobiographical Memory Interview in Patients With Depression and Healthy Controls Unknown status NCT04516863

Search NIH Clinical Center for Retrograde Amnesia

Cochrane evidence based reviews: amnesia, retrograde

Genetic Tests for Retrograde Amnesia

Anatomical Context for Retrograde Amnesia

Organs/tissues related to Retrograde Amnesia:

MalaCards : Temporal Lobe, Amygdala, Brain, Cortex, Cingulate Cortex, Prefrontal Cortex, Caudate Nucleus

Publications for Retrograde Amnesia

Articles related to Retrograde Amnesia:

(show top 50) (show all 1256)
# Title Authors PMID Year
1
Long-Term Retrograde Global Amnesia Following Minor Trauma. 62
36449412 2022
2
Diencephalic versus Hippocampal Amnesia in Alzheimer's Disease: The Possible Confabulation-Misidentification Phenotype. 62
36442200 2022
3
A Case of Transient Global Amnesia Triggered by Sexual Intercourse. 62
36415426 2022
4
Cytotoxic lesions of the corpus callosum after COVID-19 vaccination. 62
35809100 2022
5
First Pediatric Case of Autoimmune Encephalitis Associated With COVID-19 in Costa Rica. 62
36426346 2022
6
The Retrograde Memory for News Events Test (RM-NET) and the relationship between news event memory and performance on standard neuropsychological tests. 62
36180130 2022
7
Cognitive trajectories during and after electroconvulsive therapy in patients with MDE: Taking different perspectives. 62
36252342 2022
8
Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report. 62
35878559 2022
9
Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws. 62
35927567 2022
10
Behavioral, neurological, and psychiatric frailty of autobiographical memory. 62
35970754 2022
11
Test-Retest Reliability of a Semi-Structured Interview to Aid in Pediatric Traumatic Brain Injury Diagnosis. 62
34376268 2022
12
Extrahippocampal seizure and memory circuits overlap. 62
35853724 2022
13
Acute-onset amnesia: transient global amnesia and other causes. 62
35504698 2022
14
Autobiographical memory loss in Alzheimer's disease: The role of the reminiscence bump. 62
35390739 2022
15
Transient global amnesia: Model, mechanism, hypothesis. 62
35228100 2022
16
Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). 62
35436940 2022
17
Unexplained falls in the elderly. 62
34515457 2022
18
[Memory Loss - a Case of Sudden Amnesia]. 62
35473321 2022
19
Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation. 62
35149680 2022
20
Self-reported developmental changes in the frequency and characteristics of somnambulistic and sleep terror episodes in chronic sleepwalkers. 62
34990921 2022
21
Revisiting systems consolidation and the concept of consolidation. 62
34875279 2022
22
Deriving testable hypotheses through an analogy between individual and collective memory. 62
36167453 2022
23
Transient Global Amnesia. 62
35029951 2022
24
Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood. 62
35164464 2022
25
Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia. 62
35053858 2022
26
A model of bi-directional interactions between complementary learning systems for memory consolidation of sequential experiences. 62
36313529 2022
27
The effect of remimazolam on postoperative memory retention and delayed regeneration in breast surgery patients: Rationale and design of an exploratory, randomized, open, propofol-controlled, single-center clinical trial: A study protocol. 62
35049181 2021
28
"I don't know why I am in hospital": amnesia in non-fatal hanging. 62
34816049 2021
29
Distributed learning episodes create a context fear memory outside the hippocampus that depends on perirhinal and anterior cingulate cortices. 62
34663693 2021
30
Using a Likelihood Heuristic to Summarize Conflicting Literature on Predictors of Clinical Outcome Following Sport-Related Concussion. 62
32941376 2021
31
Immediate retrograde amnesia induced by midazolam: A prospective, non-randomised cohort study. 62
34037290 2021
32
Comparison of Dexmedetomidine and Midazolam in Conscious Sedation During Dental Implant Surgery: A Randomized Clinical Trial. 62
34919613 2021
33
Retrograde Amnesia Associated With Intraoperative Neuromonitoring. 62
32028375 2021
34
A case study investigating the role of the anterior temporal lobes in general semantics and semantics specific to persons, emotions and social conceptual knowledge. 62
33253487 2021
35
Retrograde amnesia of contextual fear conditioning: Evidence for retrosplenial cortex involvement in configural processing. 62
34460274 2021
36
Immediate retrograde amnesia induced by midazolam: a prospective, nonrandomized cohort study. 62
34431173 2021
37
[Systematic revision of the neural bases of dissociative amnesia]. 62
34783789 2021
38
Mechanism of seizure-induced retrograde amnesia. 62
33388373 2021
39
Amnesia in your pupils: decreased pupil size during autobiographical retrieval in a case of retrograde amnesia. 62
33739239 2021
40
Transient global amnesia after radiofrequency catheter ablation of supraventricular tachycardia: a case report. 62
33968625 2021
41
Temporal Aneurysmorrhaphy Technique for the Management of Complex Middle Cerebral Artery Aneurysm: A Video Case. 62
33540089 2021
42
MICROSURGICAL MANAGEMENT OF A RARE INCIDENTAL INTRAVENTRICULAR MENINGIOMA: A CASE REPORT AND RELEVANT LITERATURE REVIEW. 62
34588738 2021
43
Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder. 62
33859899 2021
44
Nonalcoholic Wernicke-Korsakoff Syndrome Resulting From Psychosis. 62
33620916 2021
45
Loss of Consciousness is Associated with Elevated Cognitive Intra-Individual Variability Following Sports-Related Concussion. 62
32772944 2021
46
Active Forgetting: Adaptation of Memory by Prefrontal Control. 62
32928060 2021
47
Retrograde Amnesia - A Question of Disturbed Calcium Levels? 62
34975406 2021
48
Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats. 62
34867230 2021
49
A Case of Post-Traumatic Retrograde and Anterograde Loss of Autobiographical Memory in the Absence of Medial Temporal Lobe Lesion. 62
33415050 2020
50
Retrograde amnesia: A selective deficit of explicit autobiographical memory. 62
33246579 2020

Variations for Retrograde Amnesia

Expression for Retrograde Amnesia

Search GEO for disease gene expression data for Retrograde Amnesia.

Pathways for Retrograde Amnesia

Pathways related to Retrograde Amnesia according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1 13.71 ARC BDNF CREB1 CRH EGR1 FOS
2
Show member pathways
13.25 BDNF CREB1 GRIA1 GRIA2 GRIN2A GRIN2B
3
Show member pathways
13.07 SLC6A4 NPTN GRIN2B GRIN2A GRIA2 GRIA1
4 12.77 GRIN2B FOS EGR1 CREB1 BDNF ARC
5
Show member pathways
12.6 POMC FOS CRH CREB1 BDNF
6
Show member pathways
12.54 BDNF CREB1 FOS GRIA1 GRIA2 GRIN2A
7
Show member pathways
12.46 GRIN2B FOS EGR1 CREB1 BDNF ARC
8
Show member pathways
12.39 FOS EGR1 CREB1 BDNF
9 12.29 GRIN2B GRIN2A GRIA2 GRIA1 CREB1
10
Show member pathways
12.27 GRIN2B GRIN2A GRIA2 GRIA1 CREB1
11
Show member pathways
12.26 GRIN2B GRIN2A GRIA2 CRH CREB1 BDNF
12 12.14 POMC HTR1A GRIN2B GRIN2A GRIA2 GRIA1
13 12.09 BDNF CREB1 EGR1 HTR1A SLC6A4
14 11.95 HTR1A GRIN2A GRIA2
15 11.9 FOS EGR1 BDNF
16 11.89 FOS EGR1 CREB1
17
Show member pathways
11.87 FOS EGR1 CREB1 ARC
18 11.82 CREB1 CRH FOS POMC
19
Show member pathways
11.8 GRIN2B GRIN2A GRIA2 GRIA1
20
Show member pathways
11.8 ARC BDNF CREB1 GRIA1 GRIA2 GRIN2A
21
Show member pathways
11.72 GRIN2B GRIN2A GRIA2 GRIA1 CREB1
22 11.7 POMC FOS EGR1 CREB1
23 11.69 GRIA1 CREB1 BDNF
24 11.66 FOS EGR1 CREB1
25
Show member pathways
11.59 FOS EGR1 CREB1
26
Show member pathways
11.58 CREB1 BDNF ARC
27 11.43 GRIN2B GRIN2A CREB1
28
Show member pathways
11.39 GRIN2A GRIA2 GRIA1 CREB1
29 11.37 FOS EGR1 CREB1
30 11.37 GRIN2B GRIN2A GRIA2 GRIA1 FOS CREB1
31
Show member pathways
11.25 POMC FOS EGR1
32
Show member pathways
11.23 FOS EGR1 CREB1
33
Show member pathways
11.12 POMC HTR1A FOS CRH ARC
34 11.02 GRIN2B GRIN2A GRIA2 GRIA1
35 10.92 FOS CREB1
36 10.83 CREB1 BDNF
37 10.48 POMC CRH

GO Terms for Retrograde Amnesia

Cellular components related to Retrograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 10.14 NPTN HTR1A GRIA2 GRIA1 BDNF ARC
2 dendritic spine GO:0043197 10.03 GRIN2A GRIA2 GRIA1 ARC
3 postsynaptic density GO:0014069 10.02 NPTN GRIN2B GRIN2A GRIA2 GRIA1 ARC
4 synaptic membrane GO:0097060 9.8 GRIA1 GRIN2A GRIN2B NPTN
5 synapse GO:0045202 9.77 SLC6A4 NPTN LGI1 HTR1A GRIN2B GRIN2A
6 NMDA selective glutamate receptor complex GO:0017146 9.76 GRIN2B GRIN2A
7 postsynaptic membrane GO:0045211 9.76 SLC6A4 GRIN2B GRIN2A GRIA2 GRIA1 ARC
8 obsolete integral component of postsynaptic density membrane GO:0099061 9.54 NPTN GRIN2A GRIA1
9 postsynaptic density membrane GO:0098839 9.36 NPTN GRIN2B GRIN2A GRIA2 GRIA1 ARC

Biological processes related to Retrograde Amnesia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 memory GO:0007613 9.97 SLC6A4 GRIN2A CREB1 BDNF
2 chemical synaptic transmission GO:0007268 9.93 HTR1A GRIN2B GRIN2A GRIA2 GRIA1 CRH
3 positive regulation of neuron death GO:1901216 9.91 GRIN2B FOS EGR1
4 regulation of neuronal synaptic plasticity GO:0048168 9.88 GRIN2B GRIN2A ARC
5 long-term synaptic potentiation GO:0060291 9.86 NPTN GRIN2B GRIN2A ARC
6 excitatory chemical synaptic transmission GO:0098976 9.81 GRIN2B GRIN2A
7 calcium ion transmembrane import into cytosol GO:0097553 9.8 GRIN2B GRIN2A
8 modulation of chemical synaptic transmission GO:0050804 9.8 ARC BDNF GRIN2A NPTN
9 serotonin metabolic process GO:0042428 9.78 HTR1A GRIN2A
10 regulation of monoatomic cation transmembrane transport GO:1904062 9.76 GRIN2B GRIN2A
11 ionotropic glutamate receptor signaling pathway GO:0035235 9.56 GRIN2B GRIN2A GRIA2 GRIA1
12 glutamate receptor signaling pathway GO:0007215 9.1 GRIN2B GRIN2A GRIA2 GRIA1

Molecular functions related to Retrograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid-beta binding GO:0001540 9.86 GRIA1 GRIA2 GRIN2A GRIN2B
2 NMDA glutamate receptor activity GO:0004972 9.73 GRIN2B GRIN2A
3 glutamate-gated calcium ion channel activity GO:0022849 9.71 GRIN2B GRIN2A
4 AMPA glutamate receptor activity GO:0004971 9.67 GRIA2 GRIA1
5 monoatomic ion channel activity GO:0005216 9.62 GRIN2B GRIN2A GRIA2 GRIA1
6 ligand-gated monoatomic ion channel activity GO:0015276 9.56 GRIN2B GRIN2A GRIA2 GRIA1
7 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential GO:0099507 9.46 GRIN2B GRIA1
8 ligand-gated monoatomic cation channel activity GO:0099094 9.16 GRIN2B GRIN2A
9 ionotropic glutamate receptor activity GO:0004970 9.02 GRIN2B GRIN2A GRIA2 GRIA1

Sources for Retrograde Amnesia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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