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MCID: RTR001
MIFTS: 41

Retrograde Amnesia

Categories: Mental diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Retrograde Amnesia

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MalaCards integrated aliases for Retrograde Amnesia:

Name: Retrograde Amnesia 12 76 15 73
Amnesia, Retrograde 76 44

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:4543
ICD10 33 R41.2
MeSH 44 D000648
NCIt 50 C34372
SNOMED-CT 68 51921000
UMLS 73 C0002624
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Summaries for Retrograde Amnesia

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Disease Ontology : 12 An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection.

MalaCards based summary : Retrograde Amnesia, also known as amnesia, retrograde, is related to amnestic disorder and anterograde amnesia, and has symptoms including memory loss and forgetful. An important gene associated with Retrograde Amnesia is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are ADP signalling through P2Y purinoceptor 12 and Corticotropin-releasing hormone signaling pathway. The drugs Succinylcholine and Methohexital have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation and integument

Wikipedia : 76 Retrograde amnesia (RA) is a loss of memory-access to events that occurred, or information that was... more...

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Related Diseases for Retrograde Amnesia

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Diseases related to Retrograde Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 amnestic disorder 11.8
2 anterograde amnesia 11.6
3 alzheimer disease 10.2
4 brain injury 10.2
5 encephalitis 10.2
6 head injury 10.2
7 traumatic brain injury 10.1
8 transient global amnesia 10.1
9 depression 10.1
10 hypoxia 10.1
11 aging 10.1
12 spinal cord injury 9.9 MAPK1 PDYN
13 multiple sclerosis 9.9
14 wernicke-korsakoff syndrome 9.9
15 anxiety 9.9
16 lymphoma 9.9
17 dissociative amnesia 9.9
18 cortical blindness 9.9
19 dementia 9.9
20 status epilepticus 9.9
21 craniopharyngioma 9.9
22 influenza 9.9
23 herpes simplex 9.9
24 herpes simplex encephalitis 9.9
25 headache 9.9
26 mental depression 9.9 POMC SLC6A4
27 eating disorder 9.9 POMC SLC6A4
28 cutaneous solitary mastocytoma 9.8 PDYN POMC
29 withdrawal disorder 9.8 PDYN POMC
30 pain agnosia 9.8 PDYN POMC
31 chronic fatigue syndrome 9.8 POMC SLC6A4
32 agnosia 9.8 PDYN POMC
33 substance dependence 9.7 POMC SLC6A4
34 opiate dependence 9.7 PDYN POMC SLC6A4
35 cocaine dependence 9.7 PDYN POMC SLC6A4
36 drug dependence 9.7 PDYN POMC SLC6A4
37 specific developmental disorder 9.7 PDYN POMC SLC6A4
38 disease of mental health 9.7 PDYN POMC SLC6A4
39 alcohol dependence 9.7 PDYN POMC SLC6A4

Graphical network of the top 20 diseases related to Retrograde Amnesia:



Diseases related to Retrograde Amnesia
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Symptoms & Phenotypes for Retrograde Amnesia

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UMLS symptoms related to Retrograde Amnesia:


memory loss, forgetful

GenomeRNAi Phenotypes related to Retrograde Amnesia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation GR00203-A 8.8 EIF2B1 RTN4RL1 SLC6A4

MGI Mouse Phenotypes related to Retrograde Amnesia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 CNOT3 MAPK1 PDYN POMC SLC6A4
2 liver/biliary system MP:0005370 8.92 CNOT3 MAPK1 POMC RTN4RL1
Sources

Drugs & Therapeutics for Retrograde Amnesia

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Drugs for Retrograde Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Succinylcholine Approved Phase 4 306-40-1 5314
2
Methohexital Approved Phase 4 151-83-7 9034
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4 Anesthetics, Intravenous Phase 4,Early Phase 1
5 Neuromuscular Blocking Agents Phase 4
6 Anesthetics Phase 4,Early Phase 1
7 Neuromuscular Agents Phase 4,Early Phase 1
8 Neuromuscular Depolarizing Agents Phase 4
9 Peripheral Nervous System Agents Phase 4,Early Phase 1
10 Anesthetics, General Phase 4,Early Phase 1
11 Central Nervous System Depressants Phase 4,Early Phase 1
12 Anti-Arrhythmia Agents Phase 4
13 Anesthetics, Local Phase 4
14 Diuretics, Potassium Sparing Phase 4
15 Sodium Channel Blockers Phase 4
16 Pharmaceutical Solutions Phase 4
17
Morphine Approved, Investigational Phase 3,Phase 1,Phase 2 57-27-2 5288826
18
Nitrous oxide Approved, Vet_approved Early Phase 1 10024-97-2 948
19
Diazepam Approved, Illicit, Investigational, Vet_approved Early Phase 1 439-14-5 3016
20
Midazolam Approved, Illicit Early Phase 1 59467-70-8 4192
21 Anti-Anxiety Agents Early Phase 1
22 Autonomic Agents Early Phase 1
23 GABA Modulators Early Phase 1
24 Anesthetics, Inhalation Early Phase 1
25 Anticonvulsants Early Phase 1
26 Antiemetics Early Phase 1
27 Neurotransmitter Agents Early Phase 1
28 Adjuvants, Anesthesia Early Phase 1
29 Analgesics Early Phase 1
30 Tranquilizing Agents Early Phase 1
31 Gastrointestinal Agents Early Phase 1
32 GABA Agents Early Phase 1
33 Psychotropic Drugs Early Phase 1
34 Hypnotics and Sedatives Early Phase 1
35 Analgesics, Non-Narcotic Early Phase 1
36 protein S
37 Anticoagulants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Enhancing the Effectiveness of Electroconvulsive Therapy in Severe Depression Completed NCT01907217 Phase 4 Methohexitone;Suxamethonium
2 Evaluation of the Efficacy and Safety of Administering Lidocaine Spray in Oesophago-gastro-duodenoscopy Completed NCT02733471 Phase 4 Lidocaine;Placebo
3 Magnetic Seizure Therapy (MST) for Severe Mood Disorder Completed NCT00488748 Phase 3
4 Focal Electrically-Administered Seizure Therapy (FEAST) Studies at Two Enrolling Sites to Further Test and Refine the Treatment Recruiting NCT02535572 Phase 2, Phase 3
5 Study Comparing Magnetic Seizure Therapy (MST) to Electroconvulsive Therapy (ECT) for Depression in Older Adults Completed NCT01869374 Phase 1, Phase 2
6 Comparative Evaluation of Three Anxiety Control Protocols in Third Molar Extraction Completed NCT03165500 Early Phase 1 Diazepam;Midazolam;Nitrous Oxide + Oxygen Gas
7 Prediction of the Cognitive Effects of Electroconvulsive Therapy Via Machine Learning and Neuroimaging Recruiting NCT03490149 Medication - Treatment as usual
8 Managing Severe Traumatic Brain Injury (TBI) Without Intracranial Pressure Monitoring (ICP) Monitoring Guidelines Recruiting NCT02059941
9 PROtein S100B for Mild Trauma of the HEad in Emergency Patients Not yet recruiting NCT03313505

Search NIH Clinical Center for Retrograde Amnesia

Cochrane evidence based reviews: amnesia, retrograde

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Genetic Tests for Retrograde Amnesia

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Anatomical Context for Retrograde Amnesia

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MalaCards organs/tissues related to Retrograde Amnesia:

41
Brain, Cortex, Testes, Amygdala, Temporal Lobe, Eye, Spinal Cord
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Publications for Retrograde Amnesia

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Articles related to Retrograde Amnesia:

(show top 50) (show all 453)
# Title Authors Year
1
Postictal pure retrograde amnesia. ( 29779850 )
2018
2
Utility of Retrograde Amnesia Assessment Alone, Compared with Anterograde Amnesia Assessment in Determining Recovery After Traumatic Brain Injury: Prospective Cohort Study. ( 29191531 )
2018
3
Retrograde amnesia after intravenous sedation and general anaesthesia in a dental hospital. ( 30029983 )
2018
4
Postictal pure retrograde amnesia: Response. ( 30442449 )
2018
5
Amyloid β1-42-Induced Rapid Zn2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia. ( 30460616 )
2018
6
Anterograde amnesia and disorientation are associated with in-patients without traumatic brain injury taking opioids. Retrograde amnesia (RA) is absent. RA assessment should be integral to post-traumatic amnesia testing. ( 28676317 )
2017
7
Episodic future thinking and future-based decision-making in a case of retrograde amnesia. ( 28801245 )
2017
8
Psychogenic amnesia: syndromes, outcome, and patterns of retrograde amnesia. ( 29050391 )
2017
9
Characteristics of retrograde amnesia for CS preexposure. ( 28181182 )
2017
10
Functional (dissociative) retrograde amnesia. ( 27719861 )
2017
11
Silent memory engrams as the basis for retrograde amnesia. ( 29078397 )
2017
12
Retrograde Amnesia of Contextual Fear Conditioning: Evidence for Retrosplenial Cortex Involvement in Configural Processing. ( 28054807 )
2017
13
Postictal pure retrograde amnesia. ( 28389022 )
2017
14
Retrograde Amnesia for Episodic and Semantic Memories in Amnestic Mild Cognitive Impairment. ( 28598852 )
2017
15
Dissociative amnesia: Disproportionate retrograde amnesia, stressful experiences and neurological circumstances. ( 28860028 )
2017
16
Cholinergic deafferentation of the hippocampus causes non-temporally graded retrograde amnesia in an odor discrimination task. ( 26611564 )
2016
17
Disruption of Memory Consolidation May Explain Patterns of Memory Better Than Emotion-Induced Retrograde Amnesia in Study by Chen et al. ( 27782941 )
2016
18
Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation. ( 27215477 )
2016
19
Transient Retrograde Amnesia: a focal and selective (but temporary) loss of memory for autobiographical events. ( 25626772 )
2015
20
Clinical correlates of retrograde amnesia in mild traumatic brain injury. ( 25789824 )
2015
21
Integration of New Information with Active Memory Accounts for Retrograde Amnesia: A Challenge to the Consolidation/Reconsolidation Hypothesis? ( 26290239 )
2015
22
Memory. Engram cells retain memory under retrograde amnesia. ( 26023136 )
2015
23
Rare complication of anterior communicating artery aneurysm coiling: Transient retrograde amnesia. ( 26246104 )
2015
24
Profound loss of general knowledge in retrograde amnesia: evidence from an amnesic artist. ( 24834048 )
2014
25
Hippocampal lesions produce both nongraded and temporally graded retrograde amnesia in the same rat. ( 23401223 )
2013
26
Reexposure to the amnestic agent alleviates cycloheximide-induced retrograde amnesia for reactivated and extinction memories. ( 23596315 )
2013
27
Delusion of inanimate doubles: description of a case of focal retrograde amnesia. ( 22229550 )
2012
28
On remembering and forgetting our autobiographical pasts: retrograde amnesia and Andrew Mayes's contribution to neuropsychological method. ( 22884958 )
2012
29
Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia. ( 21922193 )
2012
30
Retrograde amnesia after electroconvulsive therapy: a temporary effect? ( 21450347 )
2011
31
Focal retrograde amnesia: voxel-based morphometry findings in a case without MRI lesions. ( 22028902 )
2011
32
Prolonged inactivation of the hippocampus reveals temporally graded retrograde amnesia for unreinforced spatial learning in rats. ( 21704177 )
2011
33
Seizures and retrograde amnesia with cerebrospinal fluid changes following H1N1 influenza vaccination. ( 21840464 )
2011
34
Electroconvulsive therapy-induced persistent retrograde amnesia: could it be minimised by ketamine or other pharmacological approaches? ( 20060172 )
2010
35
Hippocampus and retrograde amnesia in the rat model: a modest proposal for the situation of systems consolidation. ( 20430043 )
2010
36
Focal retrograde amnesia: Extending the clinical syndrome of transient epileptic amnesia. ( 20598890 )
2010
37
Anti-amnesic effect of Ficus religiosa in scopolamine-induced anterograde and retrograde amnesia. ( 20645848 )
2010
38
Bupropion-induced status epilepticus and retrograde amnesia. ( 20160237 )
2010
39
Retrograde amnesia for fear-potentiated startle in rats after complete, but not partial, hippocampal damage. ( 20226233 )
2010
40
Mild cognitive impairment does entail retrograde amnesia for public events. ( 18608681 )
2009
41
Supra-normal age-linked retrograde amnesia: lessons from an older amnesic (H.M.). ( 19115388 )
2009
42
Cortical Blindness and Retrograde Amnesia Following Cerebral Angiography Studied by Early Diffusion Weighted MR imaging. A Case Report. ( 24209406 )
2009
43
Patterns of retrograde amnesia for recent and remote incidental spatial learning in rats. ( 19294648 )
2009
44
Retrograde amnesia and malingering. ( 19745730 )
2009
45
Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT. ( 18523723 )
2008
46
A dissociation between anterograde and retrograde amnesia after treatment with electroconvulsive therapy: a naturalistic investigation. ( 18580560 )
2008
47
Anterograde and retrograde amnesia of place discrimination in retrosplenial cortex and hippocampal lesioned rats. ( 18626091 )
2008
48
Retrograde amnesia associated with fornix lymphoma. ( 18645247 )
2008
49
Psychological factors in retrograde amnesia: self-deception and a broken heart. ( 18825573 )
2008
50
When the past is lost: focal retrograde amnesia. Focus on the "functional" form. ( 19641249 )
2008
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Variations for Retrograde Amnesia

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Expression for Retrograde Amnesia

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Search GEO for disease gene expression data for Retrograde Amnesia.
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Pathways for Retrograde Amnesia

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Pathways related to Retrograde Amnesia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
ADP signalling through P2Y purinoceptor 12 66
Show member pathways
 11.83 MAPK1 PDYN POMC
2
Corticotropin-releasing hormone signaling pathway 1
11.29 MAPK1 POMC
3
Glucocorticoid receptor regulatory network 1
11.17 MAPK1 POMC
4
Melanocyte Development and Pigmentation 64
10.57 MAPK1 POMC
5
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.1 MAPK1 POMC
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GO Terms for Retrograde Amnesia

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Biological processes related to Retrograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to toxic substance GO:0009636 8.96 MAPK1 SLC6A4
2 cellular response to organic substance GO:0071310 8.62 MAPK1 SLC6A4
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Sources for Retrograde Amnesia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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