Aliases & Classifications for Retrograde Amnesia

MalaCards integrated aliases for Retrograde Amnesia:

Name: Retrograde Amnesia 12 74 15 71 32
Amnesia, Retrograde 74 43

Classifications:



External Ids:

Disease Ontology 12 DOID:4543
MeSH 43 D000648
NCIt 49 C34372
SNOMED-CT 67 51921000
ICD10 32 R41.2
UMLS 71 C0002624

Summaries for Retrograde Amnesia

Disease Ontology : 12 An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection.

MalaCards based summary : Retrograde Amnesia, also known as amnesia, retrograde, is related to transient global amnesia and amnestic disorder, and has symptoms including forgetful and memory loss. An important gene associated with Retrograde Amnesia is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Transmission across Chemical Synapses and Circadian entrainment. The drugs Methohexital and Succinylcholine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and temporal lobe, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 74 Retrograde amnesia (RA) is a loss of memory-access to events that occurred or information that was... more...

Related Diseases for Retrograde Amnesia

Diseases related to Retrograde Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 transient global amnesia 30.9 CA4 BDNF
2 amnestic disorder 30.8 PDYN IMPACT HTR1A GRIN2B GRIA1 FOS
3 cerebral hypoxia 30.7 FOS CREB1
4 anterograde amnesia 29.8 TNFRSF10C IMPACT HTR1A GRIN2B FOS EGR1
5 depression 29.8 SLC6A4 HTR1A GRIA1 BDNF
6 temporal lobe epilepsy 29.5 PDYN HTR1A GRIN2B BDNF
7 status epilepticus 29.4 GRIN2B GRIA1 FOS BDNF ACHE
8 mental depression 28.7 SLC6A4 POMC HTR1A GRIN2B GRIA1 CREB1
9 major depressive disorder 28.7 SLC6A4 POMC HTR1A GRIN2B GRIA1 CREB1
10 migraine with or without aura 1 27.9 SLC6A4 POMC PDYN IMPACT HTR1A GRIN2B
11 anxiety 27.9 SLC6A4 POMC PDYN HTR1A GRIN2B CREB1
12 alzheimer disease 27.8 SLC6A4 MAPK1 HTR1A GRIN2B GRIA1 EGR1
13 head injury 10.5
14 visual epilepsy 10.4
15 seizure disorder 10.4
16 dissociative amnesia 10.4
17 encephalitis 10.4
18 acute stress disorder 10.3 SLC6A4 POMC BDNF
19 myofascial pain syndrome 10.3 POMC BDNF
20 traumatic brain injury 10.3
21 dissociative disorder 10.3 SLC6A4 GRIN2B BDNF
22 bulimia nervosa 10.2 SLC6A4 POMC BDNF
23 ocular motor apraxia 10.2
24 heroin dependence 10.2 SLC6A4 PDYN BDNF
25 amphetamine abuse 10.2 SLC6A4 ARC
26 fetal alcohol spectrum disorder 10.2 GRIN2B CREB1 BDNF
27 cocaine dependence 10.2 SLC6A4 POMC PDYN
28 morphine dependence 10.2 PDYN FOS CREB1
29 eating disorder 10.2 SLC6A4 POMC BDNF
30 huntington disease 10.2
31 viral encephalitis 10.2
32 herpes simplex encephalitis 10.2
33 anoxia 10.2
34 brain injury 10.2
35 hypoxia 10.2
36 crouzon syndrome with acanthosis nigricans 10.1 GRIN2B GRIA1 CREB1
37 vestibular nystagmus 10.1 TNFRSF10C FOS
38 wernicke-korsakoff syndrome 10.1
39 cardiac arrest 10.1
40 herpes simplex 10.1
41 48,xyyy 10.1
42 limbic encephalitis 10.1
43 aneurysm 10.1
44 landau-kleffner syndrome 10.1 POMC GRIN2B
45 drug dependence 10.0 SLC6A4 POMC PDYN BDNF
46 kaufman oculocerebrofacial syndrome 10.0 GRIN2B GRIA1 FOS BDNF
47 substance dependence 10.0 SLC6A4 POMC PDYN BDNF
48 diabetic encephalopathy 10.0 CREB1 BDNF
49 occlusion precerebral artery 10.0 GRIN2B FOS CA4 BDNF
50 inhibited male orgasm 10.0 SLC6A4 HTR1A

Graphical network of the top 20 diseases related to Retrograde Amnesia:



Diseases related to Retrograde Amnesia

Symptoms & Phenotypes for Retrograde Amnesia

UMLS symptoms related to Retrograde Amnesia:


forgetful, memory loss

MGI Mouse Phenotypes related to Retrograde Amnesia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 ACHE ARC BDNF CNOT3 CREB1 EGR1
2 growth/size/body region MP:0005378 10.21 ACHE ARC BDNF CA4 CNOT3 CREB1
3 homeostasis/metabolism MP:0005376 10.17 ACHE BDNF CA4 CNOT3 CREB1 EGR1
4 mortality/aging MP:0010768 9.97 ACHE ARC BDNF CA4 CNOT3 CREB1
5 integument MP:0010771 9.91 BDNF CNOT3 EGR1 FOS GRIA1 MAPK1
6 nervous system MP:0003631 9.77 ACHE ARC BDNF CREB1 EGR1 FOS
7 no phenotypic analysis MP:0003012 9.23 ACHE ARC BDNF GRIA1 GRIN2B HTR1A

Drugs & Therapeutics for Retrograde Amnesia

Drugs for Retrograde Amnesia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methohexital Approved Phase 4 151-83-7 9034
2
Succinylcholine Approved Phase 4 306-40-1 5314
3
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
4 Anesthetics Phase 4
5 Anesthetics, Intravenous Phase 4
6 Anesthetics, General Phase 4
7 Neuromuscular Blocking Agents Phase 4
8 Excitatory Amino Acid Antagonists Phase 4
9 Anesthetics, Dissociative Phase 4
10 Analgesics Phase 4
11
Morphine Approved, Investigational Phase 3 57-27-2 5288826
12
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
13
Midazolam Approved, Illicit Early Phase 1 59467-70-8 4192
14
Donepezil Approved 120014-06-4 3152
15
Glutamic acid Approved, Nutraceutical Early Phase 1 56-86-0 33032
16 Hypnotics and Sedatives
17 Adrenergic beta-Antagonists Early Phase 1
18 Pharmaceutical Solutions Early Phase 1
19 Psychotropic Drugs Early Phase 1
20 Anti-Anxiety Agents Early Phase 1
21 GABA Modulators Early Phase 1
22 protein S
23 Cholinergic Agents
24 Cholinesterase Inhibitors

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 A Randomised Controlled Trial of Standard Bilateral Electroconvulsive Therapy Versus High-dose Unilateral Electroconvulsive Therapy for Severe Depression Completed NCT01907217 Phase 4 Methohexitone;Suxamethonium
2 Comparing Therapeutic Efficacy and Cognitive Side Effects of Electroconvulsive Therapy (ECT) Using Ketamine Versus Methohexital Anesthesia Completed NCT01881763 Phase 4 Ketamine;Methohexital
3 Magnetic Seizure Therapy (MST) for the Treatment of Severe Mood Disorder Completed NCT00488748 Phase 3
4 Focal Electrical Administered Seizure Therapy (FEAST) for Major Depression Completed NCT01589315 Phase 2, Phase 3
5 Focal Electrically-Administered Seizure Therapy (FEAST): Studies at Two Enrolling Sites to Further Test and Refine the Treatment Completed NCT02535572 Phase 2, Phase 3
6 Sodium Butyrate As A Treatment For Improving Cognitive Function In Schizophrenia Withdrawn NCT02654405 Phase 2, Phase 3
7 Improving Outcomes in Geriatric Depression: Magnetic Seizure Therapy Active, not recruiting NCT01869374 Phase 1, Phase 2
8 The Effect on Cognition of Terminating ECT Induced Seizures With Propofol Completed NCT00616759 propofol
9 Ketamine for Depression Relapse Prevention Following ECT: a Randomised Pilot Trial With Blood Biomarker Evaluation Completed NCT02414932 Early Phase 1 Ketamine;Midazolam
10 PROtein S100B for Mild Trauma of the HEad in Emergency Patients Recruiting NCT03313505
11 Can Donepezil Preserve Autobiographical Memory Post Electroconvulsive Therapy? A Randomized, Placebo-Controlled Trial Terminated NCT02331771 Donepezil;Placebo

Search NIH Clinical Center for Retrograde Amnesia

Cochrane evidence based reviews: amnesia, retrograde

Genetic Tests for Retrograde Amnesia

Anatomical Context for Retrograde Amnesia

MalaCards organs/tissues related to Retrograde Amnesia:

40
Brain, Cortex, Temporal Lobe, Testes, Amygdala, Thalamus, Eye

Publications for Retrograde Amnesia

Articles related to Retrograde Amnesia:

(show top 50) (show all 1198)
# Title Authors PMID Year
1
Transient global amnesia following carotid artery stenting: A case report. 61
32528605 2020
2
Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia. 61
32381542 2020
3
Forget the stress: retrograde amnesia for the stress-induced impairment of extinction retrieval. 61
32295837 2020
4
Does hippocampal atrophy explain anterograde and retrograde amnesia following autoimmune limbic encephalitis? 61
32320116 2020
5
Transient epileptic amnesia diagnosed using long-term electroencephalography. 61
32301725 2020
6
Neuropathology of a remarkable case of memory impairment informs human memory. 61
31972232 2020
7
The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats. 61
31954736 2020
8
Encoding of contextual fear memory in hippocampal-amygdala circuit. 61
32170133 2020
9
Retrograde Amnesia Associated With Intraoperative Neuromonitoring. 61
32028375 2020
10
Retrograde amnesia with transposition in the past: A neuropsychological and PET study of a case. 61
31789565 2020
11
Effects of magnetic seizure therapy on anterograde and retrograde amnesia in treatment-resistant depression. 61
31682325 2020
12
Emotional memory in bipolar disorder: Impact of multiple episodes and childhood trauma. 61
31505398 2020
13
Lost or unavailable? Exploring mechanisms that affect retrograde memory in mild cognitive impairment and Alzheimer's disease patients. 61
31571005 2020
14
Comparison of Three Anxiety Management Protocols for Extraction of Third Molars With the Use of Midazolam, Diazepam, and Nitrous Oxide: A Randomized Clinical Trial. 61
31319053 2019
15
Influence of midazolam-related genetic polymorphism on conscious sedation during upper gastrointestinal endoscopy in a Korean population. 61
31690757 2019
16
Anomalies of Autobiographical Memory. 61
31474234 2019
17
Sleep Terrors: An Updated Review. 61
31612833 2019
18
Has multiple trace theory been refuted? 61
31584226 2019
19
Transient Global Amnesia in a 60-year-old female with Post-traumatic Stress Disorder. 61
31728239 2019
20
Smell your memories: Positive effect of odor exposure on recent and remote autobiographical memories in Alzheimer's disease. 61
30890017 2019
21
Parallel pathways of seizure generalization. 61
31237945 2019
22
Hippocampal Damage Causes Retrograde Amnesia and Slower Acquisition of a Cue-Place Discrimination in a Concurrent Cue-Place Water Task in Rats. 61
31195054 2019
23
Amyloid β1-42-Induced Rapid Zn2+ Influx into Dentate Granule Cells Attenuates Maintained LTP Followed by Retrograde Amnesia. 61
30460616 2019
24
Sport-Related Structural Brain Injury in High School Soccer: Epidural Hemorrhage After a "Header". 61
30928598 2019
25
Muscarinic activity in hippocampus and entorhinal cortex is crucial for spatial and fear memory retrieval. 61
31003156 2019
26
The Long-Term Risk of Dementia after Transient Global Amnesia: A Population-Based Cohort Study in Taiwan. 61
31422402 2019
27
Retrograde Autobiographical Memory From PTA Emergence to Six-Month Follow-Up in Moderate to Severe Traumatic Brain Injury. 61
30404534 2019
28
Memory integration: An alternative to the consolidation/reconsolidation hypothesis. 61
30343034 2018
29
Postictal pure retrograde amnesia. 61
29779850 2018
30
Postictal pure retrograde amnesia: Response. 61
30442449 2018
31
Temporary Memory Steal: Transient Global Amnesia Secondary to Nephrolithiasis. 61
30443620 2018
32
Retrograde Personal Semantic Memory During Post-Traumatic Amnesia and Following Emergence. 61
30196802 2018
33
[Cognitive deficits associated with electroconvulsive therapy for depression: moderating factors and neuropsychological tests]. 61
30654401 2018
34
Isolated Fornix Infarction with Damage to the Limbic System as a Cause of Persistent Amnesia: A Case Report. 61
30459298 2018
35
Clinical validation of S100B in the management of a mild traumatic brain injury: issues from an interventional cohort of 1449 adult patients. 61
29924734 2018
36
Risk factors of transient global amnesia: Three case reports. 61
30313071 2018
37
Retrograde amnesia after intravenous sedation and general anaesthesia in a dental hospital. 61
30029983 2018
38
Gender dependent contribution of muscarinic receptors in memory retrieval under sub-chronic stress. 61
29775673 2018
39
Investigating the transition from recent to remote memory using advanced tools. 61
28939475 2018
40
[Medial Temporal Lobe Amnesia]. 61
29997274 2018
41
[Psychogenic Retrograde and Anterograde Amnesia]. 61
29997276 2018
42
Synapse-specific representation of the identity of overlapping memory engrams. 61
29903972 2018
43
Factors associated with post-concussion syndrome in high school student-athletes. 61
28939003 2018
44
Computed tomography of the head for adult patients with minor head injury: are clinical decision rules a necessary evil? 61
28540393 2018
45
Validation of the 10-Item Orientation Questionnaire: A New Tool for Monitoring Post-Electroconvulsive Therapy Disorientation. 61
28976441 2018
46
I'm shocked: informed consent in ECT and the phenomenological-self. 61
29442207 2018
47
Psychological causes of autobiographical amnesia: A study of 28 cases. 61
29050993 2018
48
Episodic future thinking and future-based decision-making in a case of retrograde amnesia. 61
28801245 2018
49
Utility of Retrograde Amnesia Assessment Alone, Compared with Anterograde Amnesia Assessment in Determining Recovery After Traumatic Brain Injury: Prospective Cohort Study. 61
29191531 2018
50
Memory Integration as a Challenge to the Consolidation/Reconsolidation Hypothesis: Similarities, Differences and Perspectives. 61
30687031 2018

Variations for Retrograde Amnesia

Expression for Retrograde Amnesia

Search GEO for disease gene expression data for Retrograde Amnesia.

Pathways for Retrograde Amnesia

Pathways related to Retrograde Amnesia according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 SLC6A4 MAPK1 GRIN2B GRIA1 CREB1 ACHE
2
Show member pathways
12.74 MAPK1 GRIN2B GRIA1 FOS CREB1 ACHE
3
Show member pathways
12.69 MAPK1 FOS EGR1 CREB1 BDNF
4
Show member pathways
12.54 PDYN MAPK1 GRIN2B GRIA1 FOS CREB1
5
Show member pathways
12.49 POMC PDYN MAPK1 CREB1
6
Show member pathways
12.41 MAPK1 FOS EGR1 CREB1
7 12.33 POMC HTR1A GRIN2B GRIA1 EGR1 CREB1
8 12.31 MAPK1 FOS EGR1 CREB1
9
Show member pathways
12.27 MAPK1 FOS EGR1 CREB1
10
Show member pathways
12.21 MAPK1 GRIN2B GRIA1 CREB1
11
Show member pathways
12.17 MAPK1 FOS CREB1 BDNF
12 12.12 SLC6A4 HTR1A EGR1 CREB1 BDNF
13
Show member pathways
11.96 MAPK1 GRIN2B GRIA1 CREB1
14 11.95 PDYN MAPK1 FOS EGR1 BDNF
15 11.93 SLC6A4 MAPK1 HTR1A
16 11.93 MAPK1 FOS EGR1 CREB1
17 11.92 MAPK1 FOS CREB1
18 11.91 MAPK1 FOS EGR1 CREB1
19 11.86 MAPK1 GRIN2B GRIA1 FOS EGR1 CREB1
20
Show member pathways
11.85 MAPK1 FOS CREB1
21 11.85 POMC MAPK1 FOS CREB1
22 11.84 MAPK1 FOS CREB1
23
Show member pathways
11.83 MAPK1 FOS EGR1
24
Show member pathways
11.83 PDYN GRIN2B GRIA1 CREB1
25 11.75 MAPK1 FOS CREB1
26 11.67 MAPK1 FOS EGR1 CREB1
27 11.63 GRIA1 CREB1 BDNF
28 11.63 POMC MAPK1 FOS EGR1 CREB1
29
Show member pathways
11.62 MAPK1 FOS EGR1
30
Show member pathways
11.57 PDYN GRIN2B GRIA1 FOS CREB1 BDNF
31 11.56 POMC MAPK1 HTR1A GRIN2B GRIA1 FOS
32 11.54 MAPK1 FOS CREB1 ACHE
33 11.43 POMC MAPK1 CREB1
34 11.4 FOS EGR1 CREB1
35 11.32 MAPK1 FOS CREB1
36 11.28 MAPK1 CREB1 BDNF ARC
37
Show member pathways
11.23 MAPK1 FOS EGR1 CREB1
38 11.22 MAPK1 CREB1 BDNF
39
Show member pathways
11.17 MAPK1 FOS EGR1
40
Show member pathways
11.15 POMC MAPK1 FOS EGR1
41 11.12 MAPK1 FOS CREB1
42 11.01 MAPK1 EGR1 CREB1
43 10.98 MAPK1 FOS CREB1
44 10.85 MAPK1 CREB1 BDNF
45 10.76 MAPK1 FOS

GO Terms for Retrograde Amnesia

Cellular components related to Retrograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic density GO:0014069 9.56 MAPK1 GRIN2B GRIA1 ARC
2 dendrite GO:0030425 9.55 PDYN HTR1A GRIA1 BDNF ARC
3 synapse GO:0045202 9.43 SLC6A4 HTR1A GRIN2B GRIA1 ARC ACHE
4 postsynaptic density membrane GO:0098839 8.8 GRIN2B GRIA1 ARC

Biological processes related to Retrograde Amnesia according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.8 SLC6A4 FOS CREB1 BDNF
2 response to toxic substance GO:0009636 9.65 SLC6A4 MAPK1 FOS
3 circadian rhythm GO:0007623 9.61 SLC6A4 CREB1 BDNF
4 memory GO:0007613 9.58 SLC6A4 CREB1 BDNF
5 learning or memory GO:0007611 9.54 MAPK1 GRIN2B BDNF
6 vasoconstriction GO:0042310 9.51 SLC6A4 HTR1A
7 long-term synaptic potentiation GO:0060291 9.5 MAPK1 GRIN2B ARC
8 neurotransmitter biosynthetic process GO:0042136 9.46 SLC6A4 ACHE
9 positive regulation of neuron death GO:1901216 9.43 GRIN2B FOS EGR1
10 chemical synaptic transmission GO:0007268 9.35 PDYN MAPK1 HTR1A GRIN2B GRIA1
11 cellular response to organic substance GO:0071310 9.33 SLC6A4 MAPK1 EGR1
12 modulation of chemical synaptic transmission GO:0050804 8.92 GRIN2B GRIA1 BDNF ARC

Molecular functions related to Retrograde Amnesia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ionotropic glutamate receptor activity GO:0004970 9.16 GRIN2B GRIA1
2 serotonin binding GO:0051378 8.96 SLC6A4 HTR1A
3 amyloid-beta binding GO:0001540 8.8 GRIN2B GRIA1 ACHE

Sources for Retrograde Amnesia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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