Retrograde Amnesia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Retrograde Amnesia, also known as amnesia, retrograde, is related to anterograde amnesia and amnestic disorder, and has symptoms including forgetful and memory loss. An important gene associated with Retrograde Amnesia is NPTN (Neuroplastin), and among its related pathways/superpathways are Signal Transduction and CREB Pathway. Affiliated tissues include temporal lobe, amygdala and brain, and related phenotypes are nervous system and homeostasis/metabolism

Wikipedia: ⁷⁵ In neurology, retrograde amnesia (RA) is a loss of memory-access to events that occurred or information... more...

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Related Diseases for Retrograde Amnesia

Diseases related to Retrograde Amnesia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)

#	Related Disease	Score	Top Affiliating Genes
1	anterograde amnesia	31.5	LGI1 HTR1A FOS EGR1 CA4 BDNF
2	amnestic disorder	31.4	LGI1 HTR1A GRIN2B GRIN2A GRIA1 FOS
3	transient global amnesia	30.9	LGI1 CA4
4	limbic encephalitis	30.3	LGI1 GRIN2B GRIA1
5	dissociative amnesia	30.3	LGI1 CRH CA4 BDNF
6	temporal lobe epilepsy	30.2	LGI1 HTR1A GRIN2B BDNF
7	premature ovarian failure 7	29.9	POMC CRH
8	status epilepticus	29.5	LGI1 GRIN2B GRIA2 GRIA1 FOS BDNF
9	endogenous depression	29.1	SLC6A4 POMC HTR1A CRH CREB1 BDNF
10	major depressive disorder	29.0	SLC6A4 POMC HTR1A GRIA1 FOS CRH
11	alcohol dependence	28.8	SLC6A4 POMC HTR1A GRIN2B GRIN2A CRH
12	alzheimer disease, familial, 1	28.0	SLC6A4 HTR1A GRIN2B GRIN2A GRIA2 GRIA1
13	visual epilepsy	10.4
14	encephalitis	10.4
15	developmental and epileptic encephalopathy 30	10.3	POMC FOS
16	wernicke-korsakoff syndrome	10.3
17	dementia	10.2
18	traumatic brain injury	10.2
19	von economo's disease	10.2	LGI1 FOS
20	carotid artery occlusion	10.2	GRIN2B FOS BDNF
21	occlusion precerebral artery	10.2	GRIN2B FOS BDNF
22	amelogenesis imperfecta, type ig	10.2	FOS CREB1 BDNF
23	high pressure neurological syndrome	10.2	GRIN2B GRIN2A
24	flying phobia	10.2	POMC HTR1A GRIA1
25	motion sickness	10.2	POMC HTR1A FOS
26	cascade stomach	10.2	SLC6A4 HTR1A
27	amphetamine abuse	10.2	SLC6A4 ARC
28	huntington disease	10.2
29	viral encephalitis	10.2
30	herpes simplex encephalitis	10.2
31	cranial nerve disease	10.2	POMC LGI1 BDNF
32	drug psychosis	10.1	LGI1 HTR1A
33	auditory agnosia	10.1	LGI1 GRIN2A
34	inhibited male orgasm	10.1	SLC6A4 HTR1A
35	cyclothymic disorder	10.1	SLC6A4 HTR1A BDNF
36	drug-induced mental disorder	10.1	LGI1 HTR1A
37	morphine dependence	10.1	GRIN2B GRIA1 FOS CREB1
38	premature ejaculation	10.1	SLC6A4 HTR1A BDNF
39	cannabis abuse	10.1	SLC6A4 HTR1A BDNF
40	bipolar i disorder	10.1	SLC6A4 HTR1A BDNF
41	paranoid schizophrenia	10.1	SLC6A4 HTR1A BDNF
42	intermittent explosive disorder	10.1	SLC6A4 HTR1A
43	lingual-facial-buccal dyskinesia	10.1	LGI1 GRIN2B
44	bruxism	10.1	SLC6A4 HTR1A BDNF
45	kleptomania	10.1	SLC6A4 HTR1A GRIN2B
46	psychosexual disorder	10.1	SLC6A4 HTR1A
47	ocular motor apraxia	10.1
48	mild cognitive impairment	10.1
49	familial adult myoclonic epilepsy	10.1
50	hypokalemia	10.1

Graphical network of the top 20 diseases related to Retrograde Amnesia:

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Symptoms & Phenotypes for Retrograde Amnesia

UMLS symptoms related to Retrograde Amnesia:

forgetful; memory loss

GenomeRNAi Phenotypes related to Retrograde Amnesia according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.14	ARC BDNF CA4 CREB1 CRH EGR1
2	no effect	GR00402-S-2	10.14	BDNF CA4 CCDC177 CREB1 CRH EGR1

MGI Mouse Phenotypes related to Retrograde Amnesia:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.2	ARC BDNF CREB1 CRH EGR1 FOS
2	homeostasis/metabolism	MP:0005376	10.1	BDNF CA4 CREB1 CRH EGR1 FOS
3	growth/size/body region	MP:0005378	10	ARC BDNF CA4 CREB1 CRH EGR1
4	no phenotypic analysis	MP:0003012	9.97	ARC BDNF CRH GRIA1 GRIA2 GRIN2B
5	behavior/neurological	MP:0005386	9.86	ARC BDNF CA4 CREB1 CRH EGR1
6	integument	MP:0010771	9.36	BDNF CRH EGR1 FOS GRIA1 GRIA2

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Drugs & Therapeutics for Retrograde Amnesia

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Validation of the German Short Version of the Autobiographical Memory Interview in Patients With Depression and Healthy Controls	Unknown status	NCT04516863

Search NIH Clinical Center for Retrograde Amnesia

Cochrane evidence based reviews: amnesia, retrograde

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Genetic Tests for Retrograde Amnesia

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Anatomical Context for Retrograde Amnesia

Organs/tissues related to Retrograde Amnesia:

MalaCards : Temporal Lobe, Amygdala, Brain, Cortex, Cingulate Cortex, Prefrontal Cortex, Caudate Nucleus

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Publications for Retrograde Amnesia

Articles related to Retrograde Amnesia:

(show top 50) (show all 1256)

#	Title	Authors	PMID	Year
1	Long-Term Retrograde Global Amnesia Following Minor Trauma. ⁶²	Stilling C...Eiset AH	36449412	2022
2	Diencephalic versus Hippocampal Amnesia in Alzheimer's Disease: The Possible Confabulation-Misidentification Phenotype. ⁶²	Abbate C...Rossi PD	36442200	2022
3	A Case of Transient Global Amnesia Triggered by Sexual Intercourse. ⁶²	Askar E...Singh N	36415426	2022
4	Cytotoxic lesions of the corpus callosum after COVID-19 vaccination. ⁶²	Ohara H...Kinoshita M	35809100	2022
5	First Pediatric Case of Autoimmune Encephalitis Associated With COVID-19 in Costa Rica. ⁶²	Scheuermeier M...Ulate-Campos A	36426346	2022
6	The Retrograde Memory for News Events Test (RM-NET) and the relationship between news event memory and performance on standard neuropsychological tests. ⁶²	Cawley-Bennett ATJ...Smith CN	36180130	2022
7	Cognitive trajectories during and after electroconvulsive therapy in patients with MDE: Taking different perspectives. ⁶²	Hebbrecht K...Van Diermen L	36252342	2022
8	Hippocampal ischaemia from accidental 5-Hydroxytryptophan (5-HTP) overdose case report. ⁶²	Nash E...Jamshidi N	35878559	2022
9	Randomly fluctuating neural connections may implement a consolidation mechanism that explains classic memory laws. ⁶²	Murre JMJ	35927567	2022
10	Behavioral, neurological, and psychiatric frailty of autobiographical memory. ⁶²	Markowitsch HJ...Staniloiu A	35970754	2022
11	Test-Retest Reliability of a Semi-Structured Interview to Aid in Pediatric Traumatic Brain Injury Diagnosis. ⁶²	Hergert DC...Mayer AR	34376268	2022
12	Extrahippocampal seizure and memory circuits overlap. ⁶²	Naik AA...Kapur J	35853724	2022
13	Acute-onset amnesia: transient global amnesia and other causes. ⁶²	Miller TD...Butler CR	35504698	2022
14	Autobiographical memory loss in Alzheimer's disease: The role of the reminiscence bump. ⁶²	Berntsen D...Kopelman MD	35390739	2022
15	Transient global amnesia: Model, mechanism, hypothesis. ⁶²	Larner AJ	35228100	2022
16	Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE). ⁶²	Verdijk JPAJ...van Waarde JA	35436940	2022
17	Unexplained falls in the elderly. ⁶²	Rafanelli M...Ungar A	34515457	2022
18	[Memory Loss - a Case of Sudden Amnesia]. ⁶²	Taheri S...Peters N	35473321	2022
19	Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation. ⁶²	Tome DF...Clopath C	35149680	2022
20	Self-reported developmental changes in the frequency and characteristics of somnambulistic and sleep terror episodes in chronic sleepwalkers. ⁶²	Kalantari N...Zadra A	34990921	2022
21	Revisiting systems consolidation and the concept of consolidation. ⁶²	Gisquet-Verrier P...Riccio DC	34875279	2022
22	Deriving testable hypotheses through an analogy between individual and collective memory. ⁶²	Anastasio TJ	36167453	2022
23	Transient Global Amnesia. ⁶²	Sealy D...Johnson K	35029951	2022
24	Digital dementia in the internet generation: excessive screen time during brain development will increase the risk of Alzheimer's disease and related dementias in adulthood. ⁶²	Manwell LA...Eikelboom R	35164464	2022
25	Increased Pupil Size during Future Thinking in a Subject with Retrograde Amnesia. ⁶²	Boutoleau-Bretonniere C...El Haj M	35053858	2022
26	A model of bi-directional interactions between complementary learning systems for memory consolidation of sequential experiences. ⁶²	Howard MD...Pilly PK	36313529	2022
27	The effect of remimazolam on postoperative memory retention and delayed regeneration in breast surgery patients: Rationale and design of an exploratory, randomized, open, propofol-controlled, single-center clinical trial: A study protocol. ⁶²	Shirozu K...Yamaura K	35049181	2021
28	"I don't know why I am in hospital": amnesia in non-fatal hanging. ⁶²	Arafat SMY...Karim AKMB	34816049	2021
29	Distributed learning episodes create a context fear memory outside the hippocampus that depends on perirhinal and anterior cingulate cortices. ⁶²	Shepherd EH...Lehmann H	34663693	2021
30	Using a Likelihood Heuristic to Summarize Conflicting Literature on Predictors of Clinical Outcome Following Sport-Related Concussion. ⁶²	Buttner F...Iverson GL	32941376	2021
31	Immediate retrograde amnesia induced by midazolam: A prospective, non-randomised cohort study. ⁶²	Sohn HM...Hwang JW	34037290	2021
32	Comparison of Dexmedetomidine and Midazolam in Conscious Sedation During Dental Implant Surgery: A Randomized Clinical Trial. ⁶²	Guldiken IN...Delilbasi C	34919613	2021
33	Retrograde Amnesia Associated With Intraoperative Neuromonitoring. ⁶²	Lawrence R...Goonasekera C	32028375	2021
34	A case study investigating the role of the anterior temporal lobes in general semantics and semantics specific to persons, emotions and social conceptual knowledge. ⁶²	Foley JA...Caine D	33253487	2021
35	Retrograde amnesia of contextual fear conditioning: Evidence for retrosplenial cortex involvement in configural processing. ⁶²	Todd TP...Bucci DJ	34460274	2021
36	Immediate retrograde amnesia induced by midazolam: a prospective, nonrandomized cohort study. ⁶²	Sohn HM...Hwang JW	34431173	2021
37	[Systematic revision of the neural bases of dissociative amnesia]. ⁶²	Cuesta C...Politis DG	34783789	2021
38	Mechanism of seizure-induced retrograde amnesia. ⁶²	Naik AA...Kapur J	33388373	2021
39	Amnesia in your pupils: decreased pupil size during autobiographical retrieval in a case of retrograde amnesia. ⁶²	El Haj M...Boutoleau-Bretonniere C	33739239	2021
40	Transient global amnesia after radiofrequency catheter ablation of supraventricular tachycardia: a case report. ⁶²	Sun S...Wang C	33968625	2021
41	Temporal Aneurysmorrhaphy Technique for the Management of Complex Middle Cerebral Artery Aneurysm: A Video Case. ⁶²	Pilipenko Y...Abramyan A	33540089	2021
42	MICROSURGICAL MANAGEMENT OF A RARE INCIDENTAL INTRAVENTRICULAR MENINGIOMA: A CASE REPORT AND RELEVANT LITERATURE REVIEW. ⁶²	Raguz M...Rotim K	34588738	2021
43	Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder. ⁶²	Reddy V...Frunzi J	33859899	2021
44	Nonalcoholic Wernicke-Korsakoff Syndrome Resulting From Psychosis. ⁶²	Alves Pereira de Carvalho Saraiva R...Coentre R	33620916	2021
45	Loss of Consciousness is Associated with Elevated Cognitive Intra-Individual Variability Following Sports-Related Concussion. ⁶²	Merritt VC...Arnett PA	32772944	2021
46	Active Forgetting: Adaptation of Memory by Prefrontal Control. ⁶²	Anderson MC...Hulbert JC	32928060	2021
47	Retrograde Amnesia - A Question of Disturbed Calcium Levels? ⁶²	Montag D	34975406	2021
48	Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats. ⁶²	Lehmann H...Glenn MJ	34867230	2021
49	A Case of Post-Traumatic Retrograde and Anterograde Loss of Autobiographical Memory in the Absence of Medial Temporal Lobe Lesion. ⁶²	Gunasekara R...Jolayemi A	33415050	2020
50	Retrograde amnesia: A selective deficit of explicit autobiographical memory. ⁶²	Cubelli R...Della Sala S	33246579	2020

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Genes for Retrograde Amnesia

Genes related to Retrograde Amnesia (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NPTN	Neuroplastin	Protein Coding	6.39	DISEASES inferred ¹⁴
2	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5.72	DISEASES inferred ¹⁴
3	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	5.62	DISEASES inferred ¹⁴
4	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	5.48	DISEASES inferred ¹⁴
5	POMC	Proopiomelanocortin	Protein Coding	5.44	DISEASES inferred ¹⁴
6	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	5.34	DISEASES inferred ¹⁴
7	ARC	Activity Regulated Cytoskeleton Associated Protein	Protein Coding	5.29	DISEASES inferred ¹⁴
8	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	5.21	DISEASES inferred ¹⁴
9	CA4	Carbonic Anhydrase 4	Protein Coding	5.14	DISEASES inferred ¹⁴
10	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	5.14	DISEASES inferred ¹⁴
11	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	5.03	DISEASES inferred ¹⁴
12	PCDHA6	Protocadherin Alpha 6	Protein Coding	5.01	DISEASES inferred ¹⁴
13	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	4.93	DISEASES inferred ¹⁴
14	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	4.9	DISEASES inferred ¹⁴
15	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	4.9	DISEASES inferred ¹⁴
16	EGR1	Early Growth Response 1	Protein Coding	4.89	DISEASES inferred ¹⁴
17	CCDC177	Coiled-Coil Domain Containing 177	Protein Coding	4.88	DISEASES inferred ¹⁴
18	CRH	Corticotropin Releasing Hormone	Protein Coding	4.82	DISEASES inferred ¹⁴
19	LARP6	La Ribonucleoprotein 6, Translational Regulator	Protein Coding	4.82	DISEASES inferred ¹⁴

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Variations for Retrograde Amnesia

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Expression for Retrograde Amnesia

Search GEO for disease gene expression data for Retrograde Amnesia.

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Pathways for Retrograde Amnesia

Pathways related to Retrograde Amnesia according to GeneCards Suite gene sharing:

(show all 37)

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	13.71	ARC BDNF CREB1 CRH EGR1 FOS
2	CREB Pathway ⁶⁴ Show member pathways Activation of PKC through GPCR ⁶⁴ Intracellular Calcium Signaling ⁶⁴ IP3 Pathway ⁶⁴	13.25	BDNF CREB1 GRIA1 GRIA2 GRIN2A GRIN2B
3	Transmission across Chemical Synapses ⁶⁶ Show member pathways Neuronal System ⁶⁶ Neurotransmitter receptors and postsynaptic signal transmission ⁶⁶	13.07	SLC6A4 NPTN GRIN2B GRIN2A GRIA2 GRIA1
4	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.77	GRIN2B FOS EGR1 CREB1 BDNF ARC
5	G-Beta Gamma Signaling ⁶⁴ Show member pathways CRHR Pathway ⁶⁴ GHRH Signaling ⁶⁴	12.6	POMC FOS CRH CREB1 BDNF
6	Neuropathic Pain-Signaling in Dorsal Horn Neurons ⁶⁴ Show member pathways Aldosterone Signaling in Epithelial Cells ⁶⁴ Cholera Infection ⁶⁴	12.54	BDNF CREB1 FOS GRIA1 GRIA2 GRIN2A
7	Signaling by NTRKs ⁶⁶ Show member pathways Activated NTRK3 signals through PI3K ⁶⁶ Activated NTRK3 signals through PLCG1 ⁶⁶ Activated NTRK3 signals through RAS ⁶⁶ Activation of TRKA receptors ⁶⁶ NGF-independant TRKA activation ⁶⁶ NTF3 activates NTRK3 signaling ⁶⁶ NTRK3 as a dependence receptor ⁶⁶ PI3K/AKT activation ⁶⁶ Retrograde neurotrophin signalling ⁶⁶ Signaling by NTRK1 (TRKA) ⁶⁶ Signaling by NTRK3 (TRKC) ⁶⁶	12.46	GRIN2B FOS EGR1 CREB1 BDNF ARC
8	Hepatocyte growth factor receptor signaling ⁷⁴ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²² Apoptosis and survival NGF signaling pathway ²² Apoptosis and survival Role of CDK5 in neuronal death and survival ²² Development HGF signaling pathway ²² Development Neurotrophin family signaling ²² Drug-mediated inhibition of MET activation ⁶⁶ MET activates PTPN11 ⁶⁶ MET activates STAT3 ⁶⁶ PLC-gamma1 signalling ⁶⁶ Trk receptor signaling mediated by PI3K and PLC-gamma ⁶¹ TRKA activation by NGF ⁶⁶	12.39	FOS EGR1 CREB1 BDNF
9	Dopamine-DARPP32 Feedback onto cAMP Pathway ⁶⁴	12.29	GRIN2B GRIN2A GRIA2 GRIA1 CREB1
10	Activation of NMDA receptors and postsynaptic events ⁶⁶ Show member pathways Activation of RAC1 downstream of NMDARs ⁶⁶ Assembly and cell surface presentation of NMDA receptors ⁶⁶ Post NMDA receptor activation events ⁶⁶	12.27	GRIN2B GRIN2A GRIA2 GRIA1 CREB1
11	Transcriptional Regulation by MECP2 ⁶⁶ Show member pathways Competing endogenous RNAs (ceRNAs) regulate PTEN translation ⁶⁶ Disorders of Developmental Biology ⁶⁶ Disorders of Nervous System Development ⁶⁶ Loss of function of MECP2 in Rett syndrome ⁶⁶ Loss of MECP2 binding ability to 5hmC-DNA ⁶⁶ Loss of MECP2 binding ability to 5mC-DNA ⁶⁶ Loss of MECP2 binding ability to the NCoR/SMRT complex ⁶⁶ Loss of phosphorylation of MECP2 at T308 ⁶⁶ MECP2 regulates neuronal receptors and channels ⁶⁶ MECP2 regulates transcription factors ⁶⁶ MECP2 regulates transcription of genes involved in GABA signaling ⁶⁶ MECP2 regulates transcription of neuronal ligands ⁶⁶ Pervasive developmental disorders ⁶⁶ Post-transcriptional silencing by small RNAs ⁶⁶ PTEN Loss of Function in Cancer ⁶⁶ Regulation of MECP2 expression and activity ⁶⁶ Regulation of PTEN mRNA translation ⁶⁶	12.26	GRIN2B GRIN2A GRIA2 CRH CREB1 BDNF
12	Neuroscience ³	12.14	POMC HTR1A GRIN2B GRIN2A GRIA2 GRIA1
13	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.09	BDNF CREB1 EGR1 HTR1A SLC6A4
14	Ca, cAMP and Lipid Signaling ³	11.95	HTR1A GRIN2A GRIA2
15	Spinal cord injury ⁷⁴	11.9	FOS EGR1 BDNF
16	Gastrin signaling pathway ⁷⁴	11.89	FOS EGR1 CREB1
17	Nuclear Events (kinase and transcription factor activation) ⁶⁶ Show member pathways NGF-stimulated transcription ⁶⁶	11.87	FOS EGR1 CREB1 ARC
18	Corticotropin-releasing hormone signaling pathway ⁷⁴	11.82	CREB1 CRH FOS POMC
19	Unblocking of NMDA receptors, glutamate binding and activation ⁶⁶ Show member pathways Long-term potentiation ⁶⁶ Negative regulation of NMDA receptor-mediated neuronal transmission ⁶⁶ Synaptic adhesion-like molecules ⁶⁶	11.8	GRIN2B GRIN2A GRIA2 GRIA1
20	Fragile X syndrome ⁷⁴ Show member pathways Pilocytic astrocytoma ⁷⁴	11.8	ARC BDNF CREB1 GRIA1 GRIA2 GRIN2A
21	Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling ²² Show member pathways DARPP-32 events ⁶⁶	11.72	GRIN2B GRIN2A GRIA2 GRIA1 CREB1
22	Glucocorticoid receptor regulatory network ⁶¹	11.7	POMC FOS EGR1 CREB1
23	MECP2 and associated Rett syndrome ⁷⁴	11.69	GRIA1 CREB1 BDNF
24	AP-1 transcription factor network ⁶¹	11.66	FOS EGR1 CREB1
25	Serotonin HTR1 group and FOS pathway ⁷⁴ Show member pathways Serotonin receptor 2 and ELK-SRF/GATA4 signaling ⁷⁴ Serotonin receptor 4/6/7 and NR3C signaling ⁷⁴	11.59	FOS EGR1 CREB1
26	BDNF-TrkB signaling ⁷⁴ Show member pathways Synaptic signaling pathways associated with autism spectrum disorder ⁷⁴	11.58	CREB1 BDNF ARC
27	NO/cGMP/PKG mediated neuroprotection ⁷⁴	11.43	GRIN2B GRIN2A CREB1
28	Common pathways underlying drug addiction ⁷⁴ Show member pathways Hippocampal synaptogenesis and neurogenesis ⁷⁴	11.39	GRIN2A GRIA2 GRIA1 CREB1
29	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.37	FOS EGR1 CREB1
30	Neuroinflammation and glutamatergic signaling ⁷⁴	11.37	GRIN2B GRIN2A GRIA2 GRIA1 FOS CREB1
31	Development_Leptin signaling via JAK/STAT and MAPK cascades ²² Show member pathways phospho-PLA2 pathway ⁶⁶	11.25	POMC FOS EGR1
32	Trk receptor signaling mediated by the MAPK pathway ⁶¹ Show member pathways Signalling to ERK5 ⁶⁶	11.23	FOS EGR1 CREB1
33	Serotonin and anxiety ⁷⁴ Show member pathways Serotonin and anxiety-related events ⁷⁴	11.12	POMC HTR1A FOS CRH ARC
34	Pathogenesis of ALS ⁶⁴	11.02	GRIN2B GRIN2A GRIA2 GRIA1
35	Nongenotropic Androgen signaling ⁶¹	10.92	FOS CREB1
36	ERK pathway in Huntington's disease ⁷⁴	10.83	CREB1 BDNF
37	Glucocorticoid Pathway (HPA Axis), Pharmacodynamics ⁶⁰	10.48	POMC CRH

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GO Terms for Retrograde Amnesia

Cellular components related to Retrograde Amnesia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	dendrite	GO:0030425	10.14	NPTN HTR1A GRIA2 GRIA1 BDNF ARC
2	dendritic spine	GO:0043197	10.03	GRIN2A GRIA2 GRIA1 ARC
3	postsynaptic density	GO:0014069	10.02	NPTN GRIN2B GRIN2A GRIA2 GRIA1 ARC
4	synaptic membrane	GO:0097060	9.8	GRIA1 GRIN2A GRIN2B NPTN
5	synapse	GO:0045202	9.77	SLC6A4 NPTN LGI1 HTR1A GRIN2B GRIN2A
6	NMDA selective glutamate receptor complex	GO:0017146	9.76	GRIN2B GRIN2A
7	postsynaptic membrane	GO:0045211	9.76	SLC6A4 GRIN2B GRIN2A GRIA2 GRIA1 ARC
8	obsolete integral component of postsynaptic density membrane	GO:0099061	9.54	NPTN GRIN2A GRIA1
9	postsynaptic density membrane	GO:0098839	9.36	NPTN GRIN2B GRIN2A GRIA2 GRIA1 ARC

Biological processes related to Retrograde Amnesia according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	memory	GO:0007613	9.97	SLC6A4 GRIN2A CREB1 BDNF
2	chemical synaptic transmission	GO:0007268	9.93	HTR1A GRIN2B GRIN2A GRIA2 GRIA1 CRH
3	positive regulation of neuron death	GO:1901216	9.91	GRIN2B FOS EGR1
4	regulation of neuronal synaptic plasticity	GO:0048168	9.88	GRIN2B GRIN2A ARC
5	long-term synaptic potentiation	GO:0060291	9.86	NPTN GRIN2B GRIN2A ARC
6	excitatory chemical synaptic transmission	GO:0098976	9.81	GRIN2B GRIN2A
7	calcium ion transmembrane import into cytosol	GO:0097553	9.8	GRIN2B GRIN2A
8	modulation of chemical synaptic transmission	GO:0050804	9.8	ARC BDNF GRIN2A NPTN
9	serotonin metabolic process	GO:0042428	9.78	HTR1A GRIN2A
10	regulation of monoatomic cation transmembrane transport	GO:1904062	9.76	GRIN2B GRIN2A
11	ionotropic glutamate receptor signaling pathway	GO:0035235	9.56	GRIN2B GRIN2A GRIA2 GRIA1
12	glutamate receptor signaling pathway	GO:0007215	9.1	GRIN2B GRIN2A GRIA2 GRIA1

Molecular functions related to Retrograde Amnesia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	amyloid-beta binding	GO:0001540	9.86	GRIA1 GRIA2 GRIN2A GRIN2B
2	NMDA glutamate receptor activity	GO:0004972	9.73	GRIN2B GRIN2A
3	glutamate-gated calcium ion channel activity	GO:0022849	9.71	GRIN2B GRIN2A
4	AMPA glutamate receptor activity	GO:0004971	9.67	GRIA2 GRIA1
5	monoatomic ion channel activity	GO:0005216	9.62	GRIN2B GRIN2A GRIA2 GRIA1
6	ligand-gated monoatomic ion channel activity	GO:0015276	9.56	GRIN2B GRIN2A GRIA2 GRIA1
7	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GO:0099507	9.46	GRIN2B GRIA1
8	ligand-gated monoatomic cation channel activity	GO:0099094	9.16	GRIN2B GRIN2A
9	ionotropic glutamate receptor activity	GO:0004970	9.02	GRIN2B GRIN2A GRIA2 GRIA1

Sources

Sources for Retrograde Amnesia

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: RTR001 MIFTS: 40	Retrograde Amnesia Categories: Mental diseases	Data Licensing For inquiries, contact: [email protected]
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