MCID: RTR007
MIFTS: 30

Retroperitoneal Leiomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Retroperitoneal Leiomyosarcoma

MalaCards integrated aliases for Retroperitoneal Leiomyosarcoma:

Name: Retroperitoneal Leiomyosarcoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5284
NCIt 50 C27904
UMLS 73 C2187547

Summaries for Retroperitoneal Leiomyosarcoma

MalaCards based summary : Retroperitoneal Leiomyosarcoma is related to leiomyosarcoma and bartholin's gland benign neoplasm, and has symptoms including pain An important gene associated with Retroperitoneal Leiomyosarcoma is ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3), and among its related pathways/superpathways is Signaling by ERBB4. The drugs Doxorubicin and Trabectedin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and liver, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Retroperitoneal Leiomyosarcoma

Diseases related to Retroperitoneal Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.8
2 bartholin's gland benign neoplasm 10.1 ERBB3 PGR
3 bartholin's gland disease 10.1 ERBB3 PGR
4 luminal breast carcinoma 10.1 ERBB3 PGR
5 infratentorial cancer 10.0 PROM1 SMARCB1
6 connective tissue cancer 10.0 SMARCB1 SMUG1
7 central nervous system cancer 10.0 PROM1 SMARCB1
8 spinal cord injury 10.0
9 liposarcoma 10.0
10 nervous system cancer 10.0 PROM1 SMARCB1
11 in situ pulmonary adenocarcinoma 10.0 PROM1 SMUG1
12 fibromuscular dysplasia 10.0 PGR REN
13 premenstrual tension 10.0 PGR REN
14 uterine anomalies 9.9 PGR SMUG1
15 uterine carcinosarcoma 9.9 ERBB3 PGR
16 female reproductive system disease 9.9 PGR SMUG1
17 reproductive system disease 9.9 PGR SMUG1
18 breast malignant phyllodes tumor 9.9 PGR PTS
19 breast benign neoplasm 9.9 PGR PTS
20 large intestine cancer 9.9 ERBB3 PROM1 SMUG1
21 thoracic benign neoplasm 9.9 PGR PTS
22 medulloblastoma 9.9 ERBB3 PROM1 SMARCB1
23 gastrointestinal system cancer 9.9 PROM1 SMUG1
24 hernia, hiatus 9.9
25 sarcoma 9.9
26 gastroparesis 9.9
27 thyroid cancer 9.9
28 intestinal pseudo-obstruction 9.9
29 extragonadal germ cell cancer 9.9
30 interdigitating dendritic cell sarcoma 9.9
31 appendicitis 9.9
32 degos 'en cocarde' erythrokeratoderma 9.9
33 germ cells tumors 9.9
34 dedifferentiated liposarcoma 9.9
35 wilms tumor 1 9.9 PGR REN SMARCB1
36 meningioma, familial 9.8 PGR SMARCB1 SMUG1
37 aortic valve disease 1 9.7 PTS REN

Graphical network of the top 20 diseases related to Retroperitoneal Leiomyosarcoma:



Diseases related to Retroperitoneal Leiomyosarcoma

Symptoms & Phenotypes for Retroperitoneal Leiomyosarcoma

UMLS symptoms related to Retroperitoneal Leiomyosarcoma:


pain

MGI Mouse Phenotypes related to Retroperitoneal Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 ERBB3 PGR PROM1 PTS REN SMARCB1
2 cardiovascular system MP:0005385 9.8 ERBB3 PGR PROM1 PTS REN SMARCB1
3 mortality/aging MP:0010768 9.8 ERBB3 PGR PROM1 PTS REN SMARCB1
4 muscle MP:0005369 9.55 ERBB3 PGR PTS REN SMARCB1
5 neoplasm MP:0002006 9.35 ERBB3 PGR PROM1 SMARCB1 SMUG1
6 pigmentation MP:0001186 8.8 ERBB3 PROM1 PTS

Drugs & Therapeutics for Retroperitoneal Leiomyosarcoma

Drugs for Retroperitoneal Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
2
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
3
Doxil Approved June 1999 Phase 1, Phase 2 31703
4 Topoisomerase Inhibitors Phase 1, Phase 2
5 Anti-Bacterial Agents Phase 1, Phase 2
6 Antibiotics, Antitubercular Phase 1, Phase 2
7 Alkylating Agents Phase 2
8 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Nilotinib and Adriamycin as Treatment in Liposarcomas and Leiomyosarcomas of Retroperitoneum Unknown status NCT02587169 Phase 1, Phase 2 Nilotinib-adriamycin
2 Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma Recruiting NCT02247544 Phase 2 Trabectedin

Search NIH Clinical Center for Retroperitoneal Leiomyosarcoma

Genetic Tests for Retroperitoneal Leiomyosarcoma

Anatomical Context for Retroperitoneal Leiomyosarcoma

MalaCards organs/tissues related to Retroperitoneal Leiomyosarcoma:

41
Spinal Cord, Kidney, Liver, Testes, Thyroid, Pancreas

Publications for Retroperitoneal Leiomyosarcoma

Articles related to Retroperitoneal Leiomyosarcoma:

(show top 50) (show all 61)
# Title Authors Year
1
Retroperitoneal Leiomyosarcoma From the Radiologic Pathology Archives. ( 30207936 )
2018
2
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma. ( 30309356 )
2018
3
Retroperitoneal leiomyosarcoma: a case report. ( 29767887 )
2017
4
Retromammary fat, axillary and arm metastases from a retroperitoneal leiomyosarcoma: report of a case with an indolent behaviour. ( 29225685 )
2017
5
Right atrial extension of a giant retroperitoneal leiomyosarcoma. ( 28469124 )
2017
6
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery. ( 28557016 )
2017
7
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. ( 28628542 )
2017
8
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma. ( 28552535 )
2017
9
Pearly Facial Nodule as a Presentation of Late Metastasis of Retroperitoneal Leiomyosarcoma. ( 28858929 )
2017
10
Surgery for recurrence in retroperitoneal leiomyosarcoma: Is it all about selection? ( 28672078 )
2017
11
Metastatic Gastric Polyp Diagnosing Retroperitoneal Leiomyosarcoma. ( 27580773 )
2016
12
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. ( 27820732 )
2016
13
Robotic Resection of Pelvic Retroperitoneal Leiomyosarcoma. ( 27678615 )
2015
14
Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma. ( 26287187 )
2015
15
A Retroperitoneal Leiomyosarcoma Presenting as an Adrenal Incidentaloma in a Subject on Warfarin. ( 26064705 )
2015
16
Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma. ( 26075444 )
2015
17
Subcutaneous Axillary and Scalp Metastases from Non-Gynecological Retroperitoneal Leiomyosarcoma: An Unusual Presentation After Surgical Resection. ( 26788272 )
2015
18
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. ( 24396471 )
2014
19
Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report. ( 24628578 )
2014
20
Giant retroperitoneal leiomyosarcoma. Multiorgan block removal. ( 25460472 )
2014
21
CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma. ( 25400738 )
2014
22
Clitoris metastasis from a retroperitoneal leiomyosarcoma: A case report. ( 24527400 )
2014
23
Cutaneous scalp metastasis as the first indication of a clinically silent retroperitoneal leiomyosarcoma and of its further relapse as metastatic widespread disease. ( 24682588 )
2014
24
Unusual presentation of retroperitoneal leiomyosarcoma mimicking an adnexal tumor with highly elevated serum CA-19-9. ( 24596823 )
2014
25
Successful management of an intra-operative pulmonary tumor embolism during resection of a retroperitoneal leiomyosarcoma. ( 23489815 )
2013
26
Incidental finding on a SPECT/CT of a retroperitoneal leiomyosarcoma imitating a hiatal hernia in 131I whole-body scan in thyroid cancer evaluation. ( 23850374 )
2013
27
Iliocaval and aortoiliac reconstruction following en bloc retroperitoneal leiomyosarcoma resection. ( 23446129 )
2013
28
Surgical management of retroperitoneal leiomyosarcoma arising from the inferior vena cava. ( 24146340 )
2013
29
Orbital metastasis of retroperitoneal leiomyosarcoma. ( 21264539 )
2012
30
Local recurrence and multi-organ metastasis of primary retroperitoneal leiomyosarcoma in unusual locations after surgical resection. ( 22470795 )
2011
31
Retroperitoneal leiomyosarcoma presenting as lower gastrointestinal bleeding: a case report and review of the literature. ( 22606416 )
2011
32
Cross-femoral venous by-pass (Palma's procedure) to relieve venous hypertension due to retroperitoneal leiomyosarcoma: a case report. ( 20690530 )
2010
33
Pancreatic and multiorgan resection with inferior vena cava reconstruction for retroperitoneal leiomyosarcoma. ( 19126222 )
2009
34
Endovascular treatment of an acutely ruptured abdominal aorta from tumor invasion by an unresectable retroperitoneal leiomyosarcoma. ( 18367373 )
2008
35
Retroperitoneal leiomyosarcoma of the inferior vena cava mimicking a liver tumor. ( 18481503 )
2008
36
Complete surgical resection of retroperitoneal leiomyosarcoma in pregnancy: a case report. ( 17851674 )
2008
37
An unusual case of aldosterone- and norepinephrine-secreting retroperitoneal leiomyosarcoma. ( 18504372 )
2008
38
FNA diagnosis of retroperitoneal leiomyosarcoma metastasizing to the breast. ( 17636496 )
2007
39
Surgical treatment of retroperitoneal leiomyosarcoma with adjuvant radiotherapy. ( 17987585 )
2007
40
Retroperitoneal leiomyosarcoma infiltrating the inferior vena cava (IVC)--a case report. ( 16512470 )
2005
41
Retroperitoneal leiomyosarcoma mimicking acute appendicitis: laparoscopic management. ( 12856853 )
2003
42
Surgical treatment of retroperitoneal leiomyosarcoma invading the inferior vena cava: report of three cases. ( 12376798 )
2002
43
Retroperitoneal leiomyosarcoma and enlarged epididymis associated with a positive pregnancy test. ( 12186103 )
2002
44
Retroperitoneal Leiomyosarcoma Associated with an Elevated beta-HCG Serum Level Mimicking Extragonadal Germ Cell Tumor. ( 18521299 )
2000
45
Retroperitoneal leiomyosarcoma of a male centenarian. ( 9952344 )
1998
46
Simultaneous occurrence of urothelial bladder carcinoma and primary retroperitoneal leiomyosarcoma. ( 9253130 )
1997
47
Gasless laparoscopic removal of retroperitoneal leiomyosarcoma. ( 7766929 )
1995
48
Retroperitoneal leiomyosarcoma and gastroparesis: a new association and review of tumor-associated intestinal pseudo-obstruction. ( 7639243 )
1995
49
Retroperitoneal leiomyosarcoma: eight cases and a literature review. ( 8522250 )
1995
50
Gastric metastases from retroperitoneal leiomyosarcoma. ( 8075548 )
1994

Variations for Retroperitoneal Leiomyosarcoma

Expression for Retroperitoneal Leiomyosarcoma

Search GEO for disease gene expression data for Retroperitoneal Leiomyosarcoma.

Pathways for Retroperitoneal Leiomyosarcoma

Pathways related to Retroperitoneal Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 ERBB3 PGR

GO Terms for Retroperitoneal Leiomyosarcoma

Molecular functions related to Retroperitoneal Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.56 ERBB3 PGR PROM1 PTS REN RPRD1B
2 identical protein binding GO:0042802 8.92 ERBB3 PGR PTS RPRD1B

Sources for Retroperitoneal Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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