MCID: RTR007
MIFTS: 28

Retroperitoneal Leiomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Retroperitoneal Leiomyosarcoma

MalaCards integrated aliases for Retroperitoneal Leiomyosarcoma:

Name: Retroperitoneal Leiomyosarcoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5284
NCIt 50 C27904
UMLS 73 C2187547

Summaries for Retroperitoneal Leiomyosarcoma

MalaCards based summary : Retroperitoneal Leiomyosarcoma is related to leiomyosarcoma and connective tissue cancer, and has symptoms including pain An important gene associated with Retroperitoneal Leiomyosarcoma is ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3), and among its related pathways/superpathways is Signaling by ERBB4. The drugs Doxorubicin and Trabectedin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, testes and thyroid, and related phenotypes are cardiovascular system and mortality/aging

Related Diseases for Retroperitoneal Leiomyosarcoma

Graphical network of the top 20 diseases related to Retroperitoneal Leiomyosarcoma:



Diseases related to Retroperitoneal Leiomyosarcoma

Symptoms & Phenotypes for Retroperitoneal Leiomyosarcoma

UMLS symptoms related to Retroperitoneal Leiomyosarcoma:


pain

MGI Mouse Phenotypes related to Retroperitoneal Leiomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ERBB3 PGR PROM1 REN SMARCB1
2 mortality/aging MP:0010768 9.63 ERBB3 PGR PROM1 REN SMARCB1 SMUG1
3 muscle MP:0005369 9.26 ERBB3 PGR REN SMARCB1
4 neoplasm MP:0002006 9.02 PROM1 SMARCB1 SMUG1 ERBB3 PGR

Drugs & Therapeutics for Retroperitoneal Leiomyosarcoma

Drugs for Retroperitoneal Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1, Phase 2 23214-92-8 31703
2
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
3
Doxil Approved June 1999 Phase 1, Phase 2 31703
4 Topoisomerase Inhibitors Phase 1, Phase 2
5 Anti-Bacterial Agents Phase 1, Phase 2
6 Antibiotics, Antitubercular Phase 1, Phase 2
7 Alkylating Agents Phase 2
8 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial of Nilotinib and Adriamycin as Treatment in Liposarcomas and Leiomyosarcomas of Retroperitoneum Unknown status NCT02587169 Phase 1, Phase 2 Nilotinib-adriamycin
2 Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma Recruiting NCT02247544 Phase 2 Trabectedin

Search NIH Clinical Center for Retroperitoneal Leiomyosarcoma

Genetic Tests for Retroperitoneal Leiomyosarcoma

Anatomical Context for Retroperitoneal Leiomyosarcoma

MalaCards organs/tissues related to Retroperitoneal Leiomyosarcoma:

41
Spinal Cord, Testes, Thyroid, Kidney, Smooth Muscle, Liver

Publications for Retroperitoneal Leiomyosarcoma

Articles related to Retroperitoneal Leiomyosarcoma:

(show top 50) (show all 62)
# Title Authors Year
1
Retroperitoneal leiomyosarcoma: a case report. ( 29767887 )
2017
2
Retromammary fat, axillary and arm metastases from a retroperitoneal leiomyosarcoma: report of a case with an indolent behaviour. ( 29225685 )
2017
3
Right atrial extension of a giant retroperitoneal leiomyosarcoma. ( 28469124 )
2017
4
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery. ( 28557016 )
2017
5
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. ( 28628542 )
2017
6
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma. ( 28552535 )
2017
7
Pearly Facial Nodule as a Presentation of Late Metastasis of Retroperitoneal Leiomyosarcoma. ( 28858929 )
2017
8
Surgery for recurrence in retroperitoneal leiomyosarcoma: Is it all about selection? ( 28672078 )
2017
9
Metastatic Gastric Polyp Diagnosing Retroperitoneal Leiomyosarcoma. ( 27580773 )
2016
10
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. ( 27820732 )
2016
11
Robotic Resection of Pelvic Retroperitoneal Leiomyosarcoma. ( 27678615 )
2015
12
Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma. ( 26287187 )
2015
13
A Retroperitoneal Leiomyosarcoma Presenting as an Adrenal Incidentaloma in a Subject on Warfarin. ( 26064705 )
2015
14
Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma. ( 26075444 )
2015
15
Subcutaneous Axillary and Scalp Metastases from Non-Gynecological Retroperitoneal Leiomyosarcoma: An Unusual Presentation After Surgical Resection. ( 26788272 )
2015
16
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. ( 24396471 )
2014
17
Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report. ( 24628578 )
2014
18
Giant retroperitoneal leiomyosarcoma. Multiorgan block removal. ( 25460472 )
2014
19
CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma. ( 25400738 )
2014
20
Clitoris metastasis from a retroperitoneal leiomyosarcoma: A case report. ( 24527400 )
2014
21
Cutaneous scalp metastasis as the first indication of a clinically silent retroperitoneal leiomyosarcoma and of its further relapse as metastatic widespread disease. ( 24682588 )
2014
22
Unusual presentation of retroperitoneal leiomyosarcoma mimicking an adnexal tumor with highly elevated serum CA-19-9. ( 24596823 )
2014
23
Successful management of an intra-operative pulmonary tumor embolism during resection of a retroperitoneal leiomyosarcoma. ( 23489815 )
2013
24
Incidental finding on a SPECT/CT of a retroperitoneal leiomyosarcoma imitating a hiatal hernia in 131I whole-body scan in thyroid cancer evaluation. ( 23850374 )
2013
25
Iliocaval and aortoiliac reconstruction following en bloc retroperitoneal leiomyosarcoma resection. ( 23446129 )
2013
26
Surgical management of retroperitoneal leiomyosarcoma arising from the inferior vena cava. ( 24146340 )
2013
27
Orbital metastasis of retroperitoneal leiomyosarcoma. ( 21264539 )
2012
28
Local recurrence and multi-organ metastasis of primary retroperitoneal leiomyosarcoma in unusual locations after surgical resection. ( 22470795 )
2011
29
Retroperitoneal leiomyosarcoma presenting as lower gastrointestinal bleeding: a case report and review of the literature. ( 22606416 )
2011
30
Cross-femoral venous by-pass (Palma's procedure) to relieve venous hypertension due to retroperitoneal leiomyosarcoma: a case report. ( 20690530 )
2010
31
Strong smooth muscle differentiation is dependent on myocardin gene amplification in most human retroperitoneal leiomyosarcomas. ( 19276386 )
2009
32
Pancreatic and multiorgan resection with inferior vena cava reconstruction for retroperitoneal leiomyosarcoma. ( 19126222 )
2009
33
Endovascular treatment of an acutely ruptured abdominal aorta from tumor invasion by an unresectable retroperitoneal leiomyosarcoma. ( 18367373 )
2008
34
Retroperitoneal leiomyosarcoma of the inferior vena cava mimicking a liver tumor. ( 18481503 )
2008
35
Complete surgical resection of retroperitoneal leiomyosarcoma in pregnancy: a case report. ( 17851674 )
2008
36
An unusual case of aldosterone- and norepinephrine-secreting retroperitoneal leiomyosarcoma. ( 18504372 )
2008
37
FNA diagnosis of retroperitoneal leiomyosarcoma metastasizing to the breast. ( 17636496 )
2007
38
Surgical treatment of retroperitoneal leiomyosarcoma with adjuvant radiotherapy. ( 17987585 )
2007
39
Retroperitoneal leiomyosarcoma infiltrating the inferior vena cava (IVC)--a case report. ( 16512470 )
2005
40
Retroperitoneal leiomyosarcoma mimicking acute appendicitis: laparoscopic management. ( 12856853 )
2003
41
Surgical treatment of retroperitoneal leiomyosarcoma invading the inferior vena cava: report of three cases. ( 12376798 )
2002
42
Retroperitoneal leiomyosarcoma and enlarged epididymis associated with a positive pregnancy test. ( 12186103 )
2002
43
Evaluation of putative molecular biomarkers in abdominal and retroperitoneal leiomyosarcomas. ( 11289760 )
2001
44
Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. ( 11684951 )
2001
45
Retroperitoneal Leiomyosarcoma Associated with an Elevated beta-HCG Serum Level Mimicking Extragonadal Germ Cell Tumor. ( 18521299 )
2000
46
Retroperitoneal leiomyosarcoma of a male centenarian. ( 9952344 )
1998
47
Simultaneous occurrence of urothelial bladder carcinoma and primary retroperitoneal leiomyosarcoma. ( 9253130 )
1997
48
Gasless laparoscopic removal of retroperitoneal leiomyosarcoma. ( 7766929 )
1995
49
Retroperitoneal leiomyosarcoma and gastroparesis: a new association and review of tumor-associated intestinal pseudo-obstruction. ( 7639243 )
1995
50
Retroperitoneal leiomyosarcoma: eight cases and a literature review. ( 8522250 )
1995

Variations for Retroperitoneal Leiomyosarcoma

Expression for Retroperitoneal Leiomyosarcoma

Search GEO for disease gene expression data for Retroperitoneal Leiomyosarcoma.

Pathways for Retroperitoneal Leiomyosarcoma

Pathways related to Retroperitoneal Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.66 ERBB3 PGR

GO Terms for Retroperitoneal Leiomyosarcoma

Sources for Retroperitoneal Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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