MCID: RTR007
MIFTS: 27

Retroperitoneal Leiomyosarcoma

Categories: Cancer diseases

Aliases & Classifications for Retroperitoneal Leiomyosarcoma

MalaCards integrated aliases for Retroperitoneal Leiomyosarcoma:

Name: Retroperitoneal Leiomyosarcoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5284
NCIt 50 C27904
UMLS 70 C2187547

Summaries for Retroperitoneal Leiomyosarcoma

MalaCards based summary : Retroperitoneal Leiomyosarcoma is related to fibrous histiocytoma and spindle cell sarcoma, and has symptoms including pain An important gene associated with Retroperitoneal Leiomyosarcoma is RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B). The drugs Trabectedin and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, pancreas and smooth muscle, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Retroperitoneal Leiomyosarcoma

Diseases related to Retroperitoneal Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 fibrous histiocytoma 29.2 KIT CD34
2 spindle cell sarcoma 29.2 KIT CD34 CALD1
3 dedifferentiated liposarcoma 29.2 KIT CD34 CALD1
4 smooth muscle tumor 28.8 KIT CD34 CALD1 ANO1
5 lipomatosis, multiple 28.8 KIT CD34 CALD1 ANO1
6 retroperitoneal sarcoma 28.1 RPRD1B RPRD1A KIT CD34 CALD1 ANO1
7 leiomyosarcoma 10.9
8 soft tissue sarcoma 10.4
9 hydronephrosis 10.0
10 liposarcoma 10.0
11 hypokalemia 10.0
12 rare tumor 10.0
13 urethra leiomyoma 10.0 KIT CALD1
14 prostate embryonal rhabdomyosarcoma 10.0 KIT CALD1
15 gastric leiomyosarcoma 10.0 KIT ANO1
16 small intestinal sarcoma 10.0 KIT ANO1
17 esophageal adenoid cystic carcinoma 10.0 KIT ANO1
18 gastric hemangioma 10.0 KIT ANO1
19 mucinous stomach adenocarcinoma 10.0 KIT ANO1
20 active peptic ulcer disease 10.0 KIT ANO1
21 uterus leiomyosarcoma 10.0 KIT CALD1
22 chondroma 9.9 KIT ANO1
23 pleomorphic liposarcoma 9.9 KIT CALD1
24 perivascular epithelioid cell tumor 9.9 KIT CALD1
25 glomangioma 9.9 CD34 CALD1
26 intravascular angioleiomyoma 9.9 CD34 CALD1
27 breast myofibroblastoma 9.9 CD34 CALD1
28 pulmonary vein leiomyosarcoma 9.9 CD34 CALD1
29 glomangiomyoma 9.9 CD34 CALD1
30 vulvar leiomyosarcoma 9.9 CD34 CALD1
31 parasagittal meningioma 9.9 CD34 ANO1
32 peritoneal benign neoplasm 9.9 CD34 CALD1
33 cystic lymphangioma 9.9 ERCC6 CD34
34 glomangiosarcoma 9.9 CD34 CALD1
35 adult fibrosarcoma 9.9 CD34 CALD1
36 cervical polyp 9.9 CD34 CALD1
37 testicular fibroma 9.9 CD34 CALD1
38 intravenous leiomyomatosis 9.9 CD34 CALD1
39 clear cell sarcoma 9.9 KIT ERBB3
40 sarcomatoid squamous cell skin carcinoma 9.9 CD34 CALD1
41 congenital granular cell tumor 9.9 CD34 CALD1
42 pulmonary artery leiomyosarcoma 9.9 CD34 ANO1
43 cutaneous leiomyosarcoma 9.9 CD34 CALD1
44 subungual glomus tumor 9.9 CD34 CALD1
45 hernia, hiatus 9.9
46 hypercholesterolemia, familial, 1 9.9
47 varicose veins 9.9
48 pancreatic cancer 9.9
49 gastric cancer 9.9
50 intestinal pseudo-obstruction 9.9

Graphical network of the top 20 diseases related to Retroperitoneal Leiomyosarcoma:



Diseases related to Retroperitoneal Leiomyosarcoma

Symptoms & Phenotypes for Retroperitoneal Leiomyosarcoma

UMLS symptoms related to Retroperitoneal Leiomyosarcoma:


pain

GenomeRNAi Phenotypes related to Retroperitoneal Leiomyosarcoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-107 9.53 ERCC6
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.53 ERBB3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-12 9.53 CD34
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.53 ERCC6
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-136 9.53 ERCC6
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-151 9.53 ERCC6
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.53 ERBB3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-188 9.53 ERCC6
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.53 ERBB3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.53 ERCC6
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.53 ERCC6
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.53 ERBB3
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.53 ERCC6
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-44 9.53 ERCC6
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.53 ERBB3
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 ERCC6

Drugs & Therapeutics for Retroperitoneal Leiomyosarcoma

Drugs for Retroperitoneal Leiomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
2 Alkylating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study on Trabectedin in Advanced Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma Completed NCT02247544 Phase 2 Trabectedin

Search NIH Clinical Center for Retroperitoneal Leiomyosarcoma

Genetic Tests for Retroperitoneal Leiomyosarcoma

Anatomical Context for Retroperitoneal Leiomyosarcoma

MalaCards organs/tissues related to Retroperitoneal Leiomyosarcoma:

40
Spinal Cord, Pancreas, Smooth Muscle, Thyroid

Publications for Retroperitoneal Leiomyosarcoma

Articles related to Retroperitoneal Leiomyosarcoma:

(show top 50) (show all 147)
# Title Authors PMID Year
1
Granulocyte colony-stimulating factor producing retroperitoneal leiomyosarcoma. 61
33718809 2021
2
Potential application value of PET/computed tomography in retroperitoneal leiomyosarcoma and a literature review. 61
33741860 2021
3
[Laparoscopic Tumor Resection for Retroperitoneal Leiomyosarcoma-A Case Report]. 61
33468880 2020
4
Low Rate of SARS-CoV-2 Infection in Adults With Active Cancer Diagnosis in a Nonendemic Region in the United States. 61
33428842 2020
5
Right Atrial Extension of a Giant Retroperitoneal Leiomyosarcoma. 61
33187045 2020
6
Images in Vascular Medicine. Multivessel obstruction and treatment in a patient with retroperitoneal leiomyosarcoma. 61
31830864 2020
7
CT imaging improves histopathological grading of retroperitoneal leiomyosarcomas. 61
31653457 2020
8
[Resection of retroperitoneal leiomyosarcoma followed by replacement of cavarenal segment of inferior vena cava]. 61
32869624 2020
9
125I brachytherapy seeds implantation for an inoperable large retroperitoneal leiomyosarcoma. 61
32474530 2020
10
Robotic resection of a giant retroperitoneal leiomyosarcoma: A case report. 61
31693012 2019
11
Tumour-bowel fistula as a possible complication of pazopanib therapy in retroperitoneal leiomyosarcoma. 61
31712231 2019
12
Outcome of iliocaval resection and reconstruction for retroperitoneal sarcoma. 61
30792153 2019
13
[An Effective Treatment of Relapsed Leiomyosarcoma with Fourth-Line Trabectedin]. 61
30914533 2019
14
[Retroperitoneal leiomyosarcoma in adult]. 61
30545691 2019
15
Retroperitoneal leiomyosarcoma mimicking gastric cancer recurrence: A case report. 61
31669956 2019
16
Surgical resection for recurrent retroperitoneal leiomyosarcoma and liposarcoma. 61
30309356 2018
17
Retroperitoneal Leiomyosarcoma From the Radiologic Pathology Archives. 61
30207936 2018
18
Pearly Facial Nodule as a Presentation of Late Metastasis of Retroperitoneal Leiomyosarcoma. 61
28858929 2018
19
[Prognostic factors analysis of Ki-67, α-SMA expression in retroperitoneal leiomyosarcoma]. 61
29730911 2018
20
[Recurrence of a Giant Retroperitoneal Leiomyosarcoma Six Years after the Initial Surgery]. 61
29394760 2017
21
Serotonin Syndrome Complicating Treatment of Ifosfamide Neurotoxicity With Methylene Blue. 61
28975823 2017
22
Surgery for recurrence in retroperitoneal leiomyosarcoma: Is it all about selection? 61
28672078 2017
23
Recurrence patterns of retroperitoneal leiomyosarcoma and impact of salvage surgery. 61
28557016 2017
24
A Rare Intramedullary Spinal Cord Metastasis from a Retroperitoneal Leiomyosarcoma Presenting as a Non-Traumatic Spinal Cord Injury. 61
28628542 2017
25
Comparison between retroperitoneal leiomyosarcoma and dedifferentiated liposarcoma. 61
28552535 2017
26
Right atrial extension of a giant retroperitoneal leiomyosarcoma. 61
28469124 2017
27
Retroperitoneal leiomyosarcoma: a case report. 61
29767887 2017
28
Retromammary fat, axillary and arm metastases from a retroperitoneal leiomyosarcoma: report of a case with an indolent behaviour. 61
29225685 2017
29
Metastatic Gastric Polyp Diagnosing Retroperitoneal Leiomyosarcoma. 61
27580773 2016
30
[A Case of Severe Hematological Toxicity in Response to Pazopanib]. 61
27306822 2016
31
[Recurrent retroperitoneal sarcoma]. 61
27879144 2016
32
Subcutaneous Axillary and Scalp Metastases from Non-Gynecological Retroperitoneal Leiomyosarcoma: An Unusual Presentation After Surgical Resection. 61
26788272 2015
33
Robotic Resection of Pelvic Retroperitoneal Leiomyosarcoma. 61
27678615 2015
34
Right Ventricle Mass Induced Coronary Artery Steal Phenomenon: A Rare Clinical Manifestation on One Leiomyosarcoma Patient. 61
27122909 2015
35
Pyrosequencing-Based Assays for Rapid Detection of HER2 and HER3 Mutations in Clinical Samples Uncover an E332E Mutation Affecting HER3 in Retroperitoneal Leiomyosarcoma. 61
26287187 2015
36
Clostridium to treat cancer: dream or reality? 61
26046067 2015
37
Prognostic factors in patients with recurrent or metastatic retroperitoneal leiomyosarcoma. 61
26075444 2015
38
A Retroperitoneal Leiomyosarcoma Presenting as an Adrenal Incidentaloma in a Subject on Warfarin. 61
26064705 2015
39
Imaging features and metastatic pattern of non-IVC retroperitoneal leiomyosarcomas: are they different from IVC leiomyosarcomas? 61
24834891 2014
40
Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report. 61
24628578 2014
41
[Expression of CD133 in primary retroperitoneal leiomyosarcoma and its relationship with Ki-67]. 61
24924889 2014
42
Cutaneous scalp metastasis as the first indication of a clinically silent retroperitoneal leiomyosarcoma and of its further relapse as metastatic widespread disease. 61
24682588 2014
43
Clitoris metastasis from a retroperitoneal leiomyosarcoma: A case report. 61
24527400 2014
44
[Predictors of local recurrence and survival in primary retroperitoneal leiomyosarcoma]. 61
24809517 2014
45
Interdigitating dendritic cell sarcoma presenting in the kidney combined with retroperitoneal leiomyosarcoma: A case report and literature review. 61
24396471 2014
46
CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma. 61
25400738 2014
47
Giant retroperitoneal leiomyosarcoma. Multiorgan block removal. 61
25460472 2014
48
Unusual presentation of retroperitoneal leiomyosarcoma mimicking an adnexal tumor with highly elevated serum CA-19-9. 61
24596823 2014
49
Surgical management of retroperitoneal leiomyosarcoma arising from the inferior vena cava. 61
24146340 2013
50
Incidental finding on a SPECT/CT of a retroperitoneal leiomyosarcoma imitating a hiatal hernia in 131I whole-body scan in thyroid cancer evaluation. 61
23850374 2013

Variations for Retroperitoneal Leiomyosarcoma

Expression for Retroperitoneal Leiomyosarcoma

Search GEO for disease gene expression data for Retroperitoneal Leiomyosarcoma.

Pathways for Retroperitoneal Leiomyosarcoma

GO Terms for Retroperitoneal Leiomyosarcoma

Cellular components related to Retroperitoneal Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apical plasma membrane GO:0016324 9.33 ERBB3 CD34 ANO1
2 basal plasma membrane GO:0009925 8.96 ERBB3 CD34
3 RNA polymerase II, holoenzyme GO:0016591 8.62 RPRD1B RPRD1A

Biological processes related to Retroperitoneal Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-end processing GO:0031124 9.26 RPRD1B RPRD1A
2 positive regulation of gene expression GO:0010628 9.26 KIT ERCC6 ERBB3 CD34
3 positive regulation of protein tyrosine kinase activity GO:0061098 9.16 ERCC6 ERBB3
4 dephosphorylation of RNA polymerase II C-terminal domain GO:0070940 8.62 RPRD1B RPRD1A

Molecular functions related to Retroperitoneal Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 KIT ERBB3
2 RNA polymerase II complex binding GO:0000993 8.96 RPRD1B RPRD1A
3 protein tyrosine kinase activator activity GO:0030296 8.62 ERCC6 ERBB3

Sources for Retroperitoneal Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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