Retroperitoneal Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: RTR010 MIFTS: 35	Retroperitoneal Sarcoma Categories: Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Retroperitoneal Sarcoma

MalaCards integrated aliases for Retroperitoneal Sarcoma:

Name: Retroperitoneal Sarcoma ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:12341

NCIt ⁵⁰ C4832

SNOMED-CT ⁶⁷ 307219002

UMLS ⁷⁰ C0585129

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Summaries for Retroperitoneal Sarcoma

Disease Ontology : ¹² A malignant retroperitoneal cancer and sarcoma that is located in the retroperitoneal space.

MalaCards based summary : Retroperitoneal Sarcoma is related to spindle cell sarcoma and sarcoma. An important gene associated with Retroperitoneal Sarcoma is RPRD1B (Regulation Of Nuclear Pre-MRNA Domain Containing 1B), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Bupivacaine and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include retroperitoneal space, kidney and bone, and related phenotypes are integument and muscle

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Related Diseases for Retroperitoneal Sarcoma

Diseases related to Retroperitoneal Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 287)

#	Related Disease	Score	Top Affiliating Genes
1	spindle cell sarcoma	30.5	SSX2 MYOG MDM2 KIT CD34 CALD1
2	sarcoma	30.4	SSX2 SMARCB1 MYOG MDM2 KIT CDK4
3	leiomyosarcoma	30.3	MYOG MLANA MDM2 KIT CDK4
4	malignant fibrous histiocytoma	30.2	MYOG MDM2 CDK4
5	liposarcoma	30.1	TSPAN31 MYOG MDM2 CDK4 CD34
6	embryonal rhabdomyosarcoma	29.8	MYOG MDM2 CDK4
7	neurilemmoma	29.6	SMARCB1 KIT CD34 ANO1
8	pleomorphic lipoma	29.4	TSPAN31 MDM2 CDK4 CD34
9	embryonal sarcoma	29.3	MYOG MDM2 KIT CDK4
10	retroperitoneal leiomyosarcoma	29.3	RPRD1B RPRD1A KIT CD34 CALD1 ANO1
11	ewing sarcoma	29.3	MYOG MDM2 KIT CDK4
12	rhabdomyosarcoma	28.8	SSX2 SMARCB1 MYOG MDM2 KIT CDK4
13	dedifferentiated liposarcoma	28.7	TSPAN31 SSX2 MYOG MDM2 KIT CDK4
14	sarcoma, synovial	28.4	SSX2 SMARCB1 MYOG MDM2 KIT CD34
15	well-differentiated liposarcoma	28.4	TSPAN31 SSX2 MYOG MLANA MDM2 KIT
16	lipomatosis, multiple	28.3	TSPAN31 MLANA MDM2 KIT CDK4 CD34
17	soft tissue sarcoma	10.6
18	ring chromosome 7	10.3	MDM2 CDK4
19	urethra leiomyoma	10.3	KIT CALD1
20	ring chromosome	10.3	MDM2 CDK4
21	mediastinum liposarcoma	10.3	MDM2 CDK4
22	glomangioma	10.3	CD34 CALD1
23	diffuse lipomatosis	10.3	MDM2 CDK4
24	lipoblastoma	10.3	MDM2 CDK4
25	malignant inflammatory fibrous histiocytoma	10.3	MDM2 CDK4
26	pancreas sarcoma	10.3	MDM2 CDK4
27	aortic malignant tumor	10.3	MDM2 CD34
28	adult liposarcoma	10.3	MDM2 CDK4
29	ovarian melanoma	10.3	MLANA CALD1
30	sclerosing liposarcoma	10.3	MDM2 CD34
31	intravascular angioleiomyoma	10.3	CD34 CALD1
32	juxtacortical osteosarcoma	10.3	MDM2 CDK4
33	breast myofibroblastoma	10.3	CD34 CALD1
34	pulmonary vein leiomyosarcoma	10.3	CD34 CALD1
35	spinal cord sarcoma	10.3	KIT CD34
36	glomangiomyoma	10.3	CD34 CALD1
37	gallbladder leiomyoma	10.3	KIT CD34
38	malignant anus melanoma	10.3	MLANA KIT
39	inflammatory liposarcoma	10.3	MDM2 CD34
40	peritoneal benign neoplasm	10.3	CD34 CALD1
41	neuronal intestinal dysplasia, type b	10.3	KIT CD34
42	malignant dermis tumor	10.3	MLANA KIT
43	mucocele of appendix	10.3	KIT CD34
44	malignant skin fibrous histiocytoma	10.3	MLANA KIT
45	benign fibrous mesothelioma	10.3	KIT CD34
46	retroperitoneal hemangiopericytoma	10.3	KIT CD34
47	vulvar melanoma	10.3	MLANA KIT
48	uterus perivascular epithelioid cell tumor	10.3	MLANA CALD1
49	penis sarcoma	10.3	MLANA CD34
50	testicular fibroma	10.3	CD34 CALD1

Graphical network of the top 20 diseases related to Retroperitoneal Sarcoma:

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Symptoms & Phenotypes for Retroperitoneal Sarcoma

MGI Mouse Phenotypes related to Retroperitoneal Sarcoma:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.56	ANO1 CD34 CDK4 KIT MDM2 MLANA
2	muscle	MP:0005369	9.1	ANO1 CDK4 KIT MDM2 MYOG SMARCB1

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Drugs & Therapeutics for Retroperitoneal Sarcoma

Drugs for Retroperitoneal Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bupivacaine

Approved, Investigational

Phase 2

2180-92-9, 38396-39-3

2474

Synonyms:

( inverted exclamation markA)-bupivacaine

(+-)-Bupivacaine

(±)-bupivacaine

(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(RS)-bupivacaine

15233-43-9

1-Butyl-2',6'-pipecoloxylidide

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

2180-92-9

38396-39-3

AB00053674

Abbott brand OF bupivacaine hydrochloride

AC1L1DRE

AC1Q5LX4

AC-2096

AH 250

AKOS001637202

Anekain

Anhydrous, bupivacaine

AR-1A0242

Astra brand OF bupivacaine hydrochloride

AstraZeneca brand OF bupivacaine hydrochloride

Aventis brand OF bupivacaine hydrochloride

Bio-0886

Bloqueina

BPBio1_000298

Braun brand OF bupivacaine hydrochloride

Braun, bupivacaina

BRD-A01636364-003-05-2

BSPBio_000270

BSPBio_002607

Bucaine

Bucaine (TN)

Bupivacain janapharm

Bupivacain RPR

Bupivacaina

Bupivacaina [INN-Spanish]

Bupivacaina braun

bupivacaine

Bupivacaine

Bupivacaine (INN)

Bupivacaine [INN:BAN]

Bupivacaine anhydrous

Bupivacaine carbonate

Bupivacaine Carbonate

Bupivacaine HCL

Bupivacaine HCL kit

Bupivacaine HCL KIT

Bupivacaine hydrochloride

Bupivacaine monohydrochloride, monohydrate

Bupivacaine Monohydrochloride, Monohydrate

Bupivacain-RPR

Bupivacainum

Bupivacainum [INN-Latin]

Bupivan

Buvacaina

C07529

C18H28N2O

Carbonate, bupivacaine

Carbostesin

cBupivacaine

CBupivacaine

CHEBI:3215

CHEMBL1098

CID2474

D07552

DB00297

DepoBupivacaine

DivK1c_000758

dl-1-Butyl-2',6'-pipecoloxylidide

DL-Bupivacaine

Dolanaest

DUR-843

EINECS 218-553-3

EINECS 253-911-2

Exparel

HMS2090F12

Hydrochloride, bupivacaine

IDI1_000758

Inibsa brand OF bupivacaine hydrochloride

Janapharm, bupivacain

Jenapharm brand OF bupivacaine hydrochloride

KBio1_000758

KBio2_002004

KBio2_004572

KBio2_007140

KBio3_001827

KBioGR_001516

KBioSS_002004

KST-1A4609

L000695

LAC-43

LS-109841

LS-2222

Marcain

Marcaina

Marcaine

Marcaine HCL

Marcaine Spinal

MLS001361336

MolPort-004-955-820

NCGC00178579-01

NCGC00178579-02

NINDS_000758

NSC119660

Pisa brand OF bupivacaine hydrochloride

Prestwick0_000305

Prestwick1_000305

Prestwick2_000305

Prestwick3_000305

Racemic bupivacaine

Sensorcaine

Sensorcaine-MPF

Sensorcaine-MPF Spinal

SMR000058218

SPBio_001558

SPBio_002489

Spectrum_001524

Spectrum2_001589

Spectrum3_000974

Spectrum4_001098

Spectrum5_001483

Strathmann brand OF bupivacaine hydrochloride

Svedocain sin vasoconstr

Transdur-Bupivacaine

UNII-Y8335394RO

Win 11318

Win 11318 HCl

Everolimus

Approved

Phase 2

159351-69-6

6442177 70789204

Synonyms:

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone

(1R,9S,12S,15R,16E,23S,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.0(sup 4,9))hexatriacont

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34as)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethy

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

001, RAD

07741_FLUKA

159351-69-6

40-O-(2-hydroxyethyl)-rapamycin

40-O-(2-Hydroxyethyl)-rapamycin

42-O-(2-Hydroxyethyl)rapamycin

Afinitor

Certican

CERTICAN(R)

CHEMBL1201755

D02714

DB01590

everolimus

Everolimus

évérolimus

Everolimus (JAN/USAN/INN)

Everolimus [USAN]

LS-143292

MolPort-003-847-342

MolPort-003-925-588

NCGC00167512-01

NVP-RAD-001

RAD 001

RAD, SDZ

RAD001

RAD-001

RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus

RAD-001C

S1120_Selleck

SDZ RAD

SDZ-RAD

UNII-9HW64Q8G6G

Zortress

Analgesics, Non-Narcotic

Phase 2

Anesthetics

Phase 2

Analgesics, Opioid

Phase 2

Anesthetics, Local

Phase 2

Immunosuppressive Agents

Phase 2

Cobalt

Approved, Experimental

7440-48-4

104729

Synonyms:

Aquacat

Co(2+)

Co(II)

CO2+

Cobalt

COBALT (II) ion

Cobalt(2+)

Cobalt(2+) ion

Cobalt(II) cation

Cobalt, elemental

Cobalt-59

Cobalto

Cobaltous ion

Cobaltum

Cobatope-57

Kobalt

Super cobalt

Interventional clinical trials:

(show all 18)

#	Name	Status	NCT ID	Phase	Drugs
1	A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS)	Unknown status	NCT01344018	Phase 3
2	Phase III Prospective Randomized Trial of Pre-Operative Intensity Modulated Radiation Therapy (IMRT) Plus Surgery Versus Surgery Alone For Primary Retroperitoneal Sarcoma	Completed	NCT00131898	Phase 3
3	A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS)	Completed	NCT00091351	Phase 3
4	A Randomized Phase III Study of Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Patients With High Risk RetroPeritoneal Sarcoma (RPS)	Recruiting	NCT04031677	Phase 3	Preoperative chemotherapy
5	Phase I/II Trial of Pre-Operative Image Guided Intensity Modulated Proton Radiation Therapy (IMPT) or Photon (IMRT) With Simultaneously Integrated Boost to the High Risk Margin for Retroperitoneal Sarcomas	Recruiting	NCT01659203	Phase 1, Phase 2
6	Randomized Controlled Trial of Repeat vs. Single Quadratus Lumborum Block to Reduce Opioid Prescriptions After Open Resection of Retroperitoneal Sarcoma ("RESQU-SARC" Trial)	Recruiting	NCT04189783	Phase 2	Liposomal Bupivacaine;Quadratus Lumborum Block
7	Use of High Precision Radiotherapy in the Management of Soft-Tissue Sarcomas	Active, not recruiting	NCT01389050	Phase 2
8	A Single-arm, Open Label Phase II Study of RAD001 in Soft Tissue Extremity and/or Retroperitoneal Sarcomas	Terminated	NCT01048723	Phase 2	RAD001
9	Phase II Study of Neoadjuvant Doxorubicin and Ifosfamide, Radiotherapy, and Surgical Resection in Patients With Primary or Recurrent Retroperitoneal Sarcoma	Withdrawn	NCT00017160	Phase 2	doxorubicin;filgrastim;ifosfamide
10	A Phase I Study of Preoperative Chemoradiation and Intraoperative Radiation Therapy in the Treatment of Retroperitoneal Sarcoma	Completed	NCT00004123	Phase 1	Doxorubicin hydrochloride (DOX)
11	Radical Resection and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of High Risk Recurrent Retroperitoneal Sarcoma	Unknown status	NCT03792867		Doxorubicin
12	Perioperative Nutritional and Hemodinamic Support in Retroperitoneal Sarcoma Patients. A Phase II Prospective Feasibility Study.	Completed	NCT03877588
13	Preoperative Imaging in Retroperitoneal Sarcoma	Completed	NCT01902667
14	REtroperitoneal SArcoma Registry (RESAR): Prospective Collection of Primary Retroperitoneal Sarcoma Patient's Data, Radiological and Pathological Material for the TransAtlantic Retroperitoneal Sarcoma Working Group	Recruiting	NCT03838718
15	Long Term Morbidity and Quality of Life After Multivisceral Resection for Primary Retroperitoneal Soft Tissue Sarcomas: a Prospective Observational Study	Active, not recruiting	NCT03480399
16	The PET-RPS Study: Utility of PET for Assessment of Response to Preoperative Chemotherapy in Primary Retroperitoneal Sarcoma (RPS)	Not yet recruiting	NCT04224948
17	A Pilot Study Investigating Preoperative Proton Radiotherapy for Retroperitoneal Sarcoma	Terminated	NCT00901836
18	Proton Radiotherapy for Retroperitoneal Sarcoma	Withdrawn	NCT01034566

Search NIH Clinical Center for Retroperitoneal Sarcoma

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Genetic Tests for Retroperitoneal Sarcoma

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Anatomical Context for Retroperitoneal Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Retroperitoneal Sarcoma:

¹⁹

Retroperitoneal Space

MalaCards organs/tissues related to Retroperitoneal Sarcoma:

⁴⁰

Kidney, Bone, Prostate, Smooth Muscle, Small Intestine, Pancreas

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Publications for Retroperitoneal Sarcoma

Articles related to Retroperitoneal Sarcoma:

(show top 50) (show all 545)

#	Title	Authors	PMID	Year
1	Defining the role of neoadjuvant systemic therapy in high-risk retroperitoneal sarcoma: A multi-institutional study from the Transatlantic Australasian Retroperitoneal Sarcoma Working Group. ⁶¹	Tseng WW...Gronchi A	33206381	2021
2	Renal Function After Retroperitoneal Sarcoma Resection with Nephrectomy: A Matched Analysis of the United States Sarcoma Collaborative Database. ⁶¹	Stahl CC...Abbott DE	33146839	2021
3	Morbidity and Outcomes After Distal Pancreatectomy for Primary Retroperitoneal Sarcoma: An Analysis by the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group. ⁶¹	Bagaria SP...Gronchi A	33740198	2021
4	ASO Author Reflections: Kidney Function After Retroperitoneal Sarcoma Resection with Nephrectomy. ⁶¹	Stahl CC...Abbott DE	33146840	2021
5	[Preoperative radiotherapy plus resection versus surgery alone in patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicenter randomized phase III study]. ⁶¹	Grabenbauer GG	33403443	2021
6	ASO Author Reflections: Every Step Counts: Improved Survival of Retroperitoneal Sarcoma Patients During the Past 15 Years. ⁶¹	Callegaro D...Swallow CJ	33057862	2021
7	The importance of the margin of resection and external radiation in non-lipomatous retroperitoneal sarcoma. ⁶¹	Littau MJ...Baker MS	33213828	2021
8	Primary mesenteric sarcomas: Collaborative experience from the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG). ⁶¹	Tattersall HL...Ford SJ	33368277	2021
9	Splenic artery dissection: an unusual clinical presentation mimicking a retroperitoneal sarcoma. ⁶¹	Coppola A...Coppola R	32621626	2021
10	Nephrectomy for Retroperitoneal Sarcoma: Stay Calm and (Cautiously) Carry On. ⁶¹	Fairweather M...Raut CP	33150550	2021
11	Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years. ⁶¹	Callegaro D...Swallow CJ	33073340	2021
12	International Collaboration for the Treatment of Recurrent Retroperitoneal Sarcoma: What Have We Learned from Trying to Fit a Square Peg in a Round Hole? ⁶¹	Feig BW	33660130	2021
13	The importance of the margin of resection and radiotherapy in retroperitoneal liposarcoma. ⁶¹	Littau MJ...Baker MS	33256943	2021
14	Risk Assessment of Visceral Sarcomas: A Comparative Study of 2698 Cases from the SEER Database. ⁶¹	Dashti NK...Cates JMM	33538930	2021
15	ASO Author Reflections: Preoperative Biopsy for Retroperitoneal Sarcoma. ⁶¹	Straker RJ...Karakousis GC	33638039	2021
16	Distal Pancreatectomy for Primary Retroperitoneal Sarcoma-Clinical Implications and Future Directions. ⁶¹	Bagaria SP...Gronchi A	33638045	2021
17	The impact of postoperative radiological surveillance intensity on disease free and overall survival from primary retroperitoneal, abdominal and pelvic soft-tissue sarcoma. ⁶¹	Glasbey JC...Ford SJ	33549374	2021
18	Preoperative Biopsy in Patients with Retroperitoneal Sarcoma: Usage and Outcomes in a National Cohort. ⁶¹	Straker RJ...Karakousis GC	33591480	2021
19	Postoperative Morbidity After Resection of Recurrent Retroperitoneal Sarcoma: A Report from the Transatlantic Australasian RPS Working Group (TARPSWG). ⁶¹	Nessim C...Lahat G	33389288	2021
20	Perioperative blood transfusion is not an independent predictor for worse outcomes in retroperitoneal sarcoma surgery. ⁶¹	Wong B...Nessim C	33483237	2021
21	Preoperative radiotherapy for retroperitoneal sarcoma. ⁶¹	Chowdhary M...Spraker MB	33387501	2021
22	Preoperative radiotherapy for retroperitoneal sarcoma. ⁶¹	DeLaney T...Kirsch DG	33387499	2021
23	Preoperative radiotherapy for retroperitoneal sarcoma - Authors' reply. ⁶¹	Bonvalot S...Haas RL	33387505	2021
24	Preoperative radiotherapy for retroperitoneal sarcoma. ⁶¹	Izzuddeen Y...Sharma DN	33387503	2021
25	Strategies for care of patients with gastrointestinal stromal tumor or soft tissue sarcoma during COVID-19 pandemic: A guide for surgical oncologists. ⁶¹	Callegaro D...Gladdy R	33022754	2021
26	Aggressive and frequent resection of recurrences in retroperitoneal sarcoma contributes to long-term survival. ⁶¹	Komori K...Shimizu Y	33449172	2021
27	What is the role of preoperative radiation in primary retroperitoneal sarcoma? ⁶¹	Roland CL	33342550	2020
28	Post-Operative Superior Mesenteric Artery Syndrome Following Retroperitoneal Sarcoma Resection. ⁶¹	Wong LH...Mayo SC	33599214	2020
29	Innate inflammatory markers for predicting survival in retroperitoneal sarcoma. ⁶¹	Netanyahu Y...Nizri E	32808301	2020
30	Retroperitoneal tumors: Review of diagnosis and management. ⁶¹	Sassa N	32914475	2020
31	Multidisciplinary Oncovascular Surgery is Safe and Effective in the Treatment of Intra-abdominal and Retroperitoneal Sarcomas: A Retrospective Single Centre Cohort Study and a Comprehensive Literature Review. ⁶¹	Homsy P...Vikatmaa P	32741678	2020
32	Analysis of textbook outcomes among patients undergoing resection of retroperitoneal sarcoma: A multi-institutional analysis of the US Sarcoma Collaborative. ⁶¹	Wiseman JT...Grignol V	32696475	2020
33	Enhanced recovery after surgery pathway in patients with soft tissue sarcoma. ⁶¹	Lyu HG...Raut CP	32618371	2020
34	Patterns of recurrence and survival probability after second recurrence of retroperitoneal sarcoma: A study from TARPSWG. ⁶¹	van Houdt WJ...Gladdy RA	32797703	2020
35	A Prospective Observational Study of Multivisceral Resection for Retroperitoneal Sarcoma: Clinical and Patient-Reported Outcomes 1 Year After Surgery. ⁶¹	Fiore M...Gronchi A	33175262	2020
36	ASO Author Reflections: Understanding the Impact of Primary Retroperitoneal Sarcoma Resection on Patient Well-being: One Step Forward in Learning How Caring for Patients is as Important as Curing Their Cancers. ⁶¹	Fiore M...Gronchi A	33249522	2020
37	Applicability of the Sarculator and MSKCC nomograms to retroperitoneal sarcoma prognostication in an Asian tertiary center. ⁶¹	Wong RX...Teo M	31941593	2020
38	Response to Central Boost Radiation Therapy in an Unresectable Retroperitoneal Sarcoma: A Case Report. ⁶¹	Lee JW...Kirsch DG	33305102	2020
39	[French ccAFU guidelines - update 2020-2022: retroperitoneal sarcoma]. ⁶¹	Murez T...Mejean A	33349428	2020
40	Postoperative Outcome of Surgery with Pancreatic Resection for Retroperitoneal Soft Tissue Sarcoma: Results of a Retrospective Bicentric Analysis on 50 Consecutive Patients. ⁶¹	Flacs M...Honore C	33236323	2020
41	[A Case of Abdominal Fullness Caused by a Retroperitoneal Bulky Tumor Treated with Epidural Analgesia]. ⁶¹	Yokota S...Hayashi K	33268739	2020
42	Integrative assessment of clinicopathological parameters and the expression of PD-L1, PD-L2 and PD-1 in tumor cells of retroperitoneal sarcoma. ⁶¹	Miyake M...Fujimoto K	32952659	2020
43	Evaluation of Preoperative Chemotherapy or Radiation and Overall Survival in Patients With Nonmetastatic, Resectable Retroperitoneal Sarcoma. ⁶¹	Ma SJ...Singh AK	33175172	2020
44	Preoperative radiotherapy plus surgery versus surgery alone for patients with primary retroperitoneal sarcoma (EORTC-62092: STRASS): a multicentre, open-label, randomised, phase 3 trial. ⁶¹	Bonvalot S...Haas RL	32941794	2020
45	Improved Biopsy Accuracy in Retroperitoneal Dedifferentiated Liposarcoma. ⁶¹	Tirotta F...Fiore M	32367501	2020
46	Primary localized retroperitoneal sarcomas: report from Slovenian sarcoma referral center. ⁶¹	Novak M...Erzen D	33109203	2020
47	Clinical Impact of Tumor-Infiltrating Lymphocytes and PD-L1-Positive Cells as Prognostic and Predictive Biomarkers in Urological Malignancies and Retroperitoneal Sarcoma. ⁶¹	Miyake M...Fujimoto K	33121123	2020
48	Discovery of a duplicated inferior vena cava during surgical resection for retroperitoneal sarcoma. ⁶¹	de Mathelin P...Delhorme JB	32513629	2020
49	Severe Postoperative Complications are Associated with Impaired Survival in Primary but not in Recurrent Retroperitoneal Sarcoma. ⁶¹	Nizri E...Klausner JM	33025356	2020
50	Virtual Biobanking for Retroperitoneal Sarcoma: A Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) Initiative. ⁶¹	Al-Sukhni E...Gladdy RA	32591952	2020

Sources

Genes for Retroperitoneal Sarcoma

Genes related to Retroperitoneal Sarcoma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RPRD1B	Regulation Of Nuclear Pre-MRNA Domain Containing 1B	Protein Coding	6.42	DISEASES inferred ¹⁵
2	MDM2	MDM2 Proto-Oncogene	Protein Coding	6.37	DISEASES inferred ¹⁵
3	CALD1	Caldesmon 1	Protein Coding	6.23	DISEASES inferred ¹⁵
4	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	6.22	DISEASES inferred ¹⁵
5	CDK4	Cyclin Dependent Kinase 4	Protein Coding	6.09	DISEASES inferred ¹⁵
6	MLANA	Melan-A	Protein Coding	6.01	DISEASES inferred ¹⁵
7	CD34	CD34 Molecule	Protein Coding	6	DISEASES inferred ¹⁵
8	RPRD1A	Regulation Of Nuclear Pre-MRNA Domain Containing 1A	Protein Coding	5.62	DISEASES inferred ¹⁵
9	ANO1	Anoctamin 1	Protein Coding	5.32	DISEASES inferred ¹⁵
10	SSX2	SSX Family Member 2	Protein Coding	5.25	DISEASES inferred ¹⁵
11	TSPAN31	Tetraspanin 31	Protein Coding	5.21	DISEASES inferred ¹⁵
12	MYOG	Myogenin	Protein Coding	5.14	DISEASES inferred ¹⁵
13	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	5.11	DISEASES inferred ¹⁵

Sources

Variations for Retroperitoneal Sarcoma

Sources

Expression for Retroperitoneal Sarcoma

Search GEO for disease gene expression data for Retroperitoneal Sarcoma.

Sources

Pathways for Retroperitoneal Sarcoma

Pathways related to Retroperitoneal Sarcoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.78	MYOG KIT CD34

Sources

GO Terms for Retroperitoneal Sarcoma

Cellular components related to Retroperitoneal Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RNA polymerase II, holoenzyme	GO:0016591	8.62	RPRD1B RPRD1A

Biological processes related to Retroperitoneal Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of muscle cell differentiation	GO:0051149	9.26	MYOG MDM2
2	negative regulation of cell cycle arrest	GO:0071157	9.16	MDM2 CDK4
3	positive regulation of cell proliferation	GO:0008284	9.02	TSPAN31 RPRD1B MDM2 KIT CDK4
4	dephosphorylation of RNA polymerase II C-terminal domain	GO:0070940	8.96	RPRD1B RPRD1A

Sources

Sources for Retroperitoneal Sarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia