MCID: RTR004
MIFTS: 39

Retroperitoneum Carcinoma

Categories: Cancer diseases

Aliases & Classifications for Retroperitoneum Carcinoma

MalaCards integrated aliases for Retroperitoneum Carcinoma:

Name: Retroperitoneum Carcinoma 12 15
Retroperitoneal Cancer 12 15 17
Malignant Neoplasm of Retroperitoneum and Peritoneum 12 32
Retroperitoneal Neoplasms 43 71
Malignant Tumor of Peritoneum and Retroperitoneum 12
Malignant Neoplasm of Retroperitoneum 12
Carcinoma of the Retroperitoneum 12
Malignant Retroperitoneal Cancer 12
Neoplasm of the Retroperitoneum 12
Carcinoma of Retroperitoneum 12
Neoplasm of Retroperitoneum 12
Retroperitoneal Neoplasm 12
Tumor of Retroperitoneum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12342 DOID:5875
ICD9CM 34 158 158.0
MeSH 43 D012186
ICD10 32 C48 C48.0
UMLS 71 C0035358 C0153464 C0153465 more

Summaries for Retroperitoneum Carcinoma

Disease Ontology : 12 An organ system cancer located in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum.

MalaCards based summary : Retroperitoneum Carcinoma, also known as retroperitoneal cancer, is related to peritoneum cancer and papillary carcinoma, and has symptoms including sister mary joseph's nodule An important gene associated with Retroperitoneum Carcinoma is SYP (Synaptophysin), and among its related pathways/superpathways are NF-kappaB Signaling and Pathways in cancer. The drugs Cisplatin and Ipilimumab have been mentioned in the context of this disorder. Affiliated tissues include retroperitoneal space, lymph node and kidney, and related phenotypes are hematopoietic system and integument

Related Diseases for Retroperitoneum Carcinoma

Diseases related to Retroperitoneum Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 475)
# Related Disease Score Top Affiliating Genes
1 peritoneum cancer 31.4 WT1 KRT7 CDKN2A
2 papillary carcinoma 30.2 SYP KRT7 KRT20
3 benign teratoma 30.2 SYP KRT7 KRT20
4 lipoblastoma 30.0 MDM2 CDK4
5 neuroendocrine carcinoma 29.8 SYP PTPRC KRT7 KRT20 KIT
6 intestinal obstruction 29.7 KRT7 KRT20 KIT CD34
7 cystic teratoma 29.7 SYP KRT7 KRT20 KIT CDKN2A
8 teratoma 29.7 SYP KRT7 KRT20 KIT CDKN2A
9 liposarcoma 29.6 MDM2 CDKN2A CDK4 CD34
10 merkel cell carcinoma 29.5 SYP PTPRC KRT7 KRT20 KIT CDKN2A
11 hemangioma 29.5 SYP KRT7 KIT F2 CD34
12 retroperitoneal sarcoma 29.4 RPRD1B MLANA MDM2 KIT CDK4 CD34
13 gastrointestinal stromal tumor 29.4 WT1 SYP KIT CDKN2A CD34
14 malignant fibrous histiocytoma 29.3 PTPRC MDM2 KIT CDK4
15 wilms tumor 1 29.3 WT1 SYP KRT7 KIT CD34
16 lymphoma 29.0 PTPRC MDM2 KIT CDKN2A CDK4
17 angiosarcoma 28.5 MLANA MDM2 KRT7 KIT CD34
18 rhabdomyosarcoma 28.5 WT1 SYP PTPRC MDM2 KIT CDKN2A
19 hemangiopericytoma, malignant 28.1 SYP MLANA MDM2 KIT CD34 CALD1
20 leiomyosarcoma 28.1 WT1 PTPRC MLANA MDM2 KIT CDKN2A
21 malignant peripheral nerve sheath tumor 27.5 WT1 MLANA MDM2 KRT7 KIT CDKN2A
22 retroperitoneal germ cell neoplasm 11.4
23 retroperitoneal neuroblastoma 11.3
24 primary peritoneal serous/papillary carcinoma 10.7
25 ovary neuroendocrine neoplasm 10.6 SYP KRT7
26 cervical basaloid squamous cell carcinoma 10.6 KRT7 CDKN2A
27 primary malignant peritoneal tumor 10.6
28 vulvar eccrine porocarcinoma 10.5 SYP CDKN2A
29 fallopian tube squamous cell carcinoma 10.5 WT1 CDKN2A
30 inverted transitional papilloma 10.5 KRT7 CDKN2A
31 mucinous adenofibroma 10.5 SYP KRT7
32 auditory system benign neoplasm 10.5 SYP KRT7
33 rectum neuroendocrine neoplasm 10.5 SYP KRT7
34 ureter small cell carcinoma 10.5 SYP KRT7
35 middle ear adenoma 10.5 SYP KRT7
36 cauda equina neoplasm 10.5 WT1 SYP
37 epithelial predominant wilms' tumor 10.5 WT1 KRT7
38 gallbladder small cell carcinoma 10.5 SYP KRT7
39 urethral villous adenoma 10.5 KRT7 KRT20
40 microinvasive cervical squamous cell carcinoma 10.5 WT1 KRT7
41 gastric signet ring cell adenocarcinoma 10.5 KRT7 KRT20
42 nephrogenic adenoma of urinary bladder 10.5 KRT7 KRT20
43 intrahepatic bile duct adenoma 10.5 KRT7 KRT20
44 seminal vesicle adenocarcinoma 10.5 KRT7 KRT20
45 urinary bladder villous adenoma 10.5 KRT7 KRT20
46 vulva adenocarcinoma 10.5 KRT7 KRT20
47 epididymal neoplasm 10.5 WT1 KRT7
48 gallbladder adenoma 10.5 KRT7 CDKN2A
49 cystitis cystica 10.5 KRT7 KRT20
50 ureteral benign neoplasm 10.5 SYP KRT7

Graphical network of the top 20 diseases related to Retroperitoneum Carcinoma:



Diseases related to Retroperitoneum Carcinoma

Symptoms & Phenotypes for Retroperitoneum Carcinoma

UMLS symptoms related to Retroperitoneum Carcinoma:


sister mary joseph's nodule

MGI Mouse Phenotypes related to Retroperitoneum Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 CD34 CDK4 CDKN2A F2 KIT MDM2
2 integument MP:0010771 9.86 CD34 CDK4 CDKN2A F2 KIT MDM2
3 neoplasm MP:0002006 9.7 CD34 CDK4 CDKN2A KIT MDM2 PTPRC
4 no phenotypic analysis MP:0003012 9.43 CDKN2A KIT MDM2 MLANA PTPRC WT1
5 pigmentation MP:0001186 9.02 CDK4 CDKN2A KIT MDM2 MLANA

Drugs & Therapeutics for Retroperitoneum Carcinoma

Drugs for Retroperitoneum Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
2
Ipilimumab Approved Phase 1 477202-00-9
3
nivolumab Approved Phase 1 946414-94-4
4 Tubulin Modulators Phase 1
5 Halichondrin B Phase 1
6 Antimitotic Agents Phase 1
7 Immunoglobulins Phase 1
8 Antibodies Phase 1
9 Antibodies, Monoclonal Phase 1
10 Antineoplastic Agents, Immunological Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anti-1-amino-3-18F-flurocyclobutane-1-carboxylic Acid (Axumin) Positron Emission Tomography/Computed Tomography Prior to Retroperitoneal Lymph Node Dissection for Testicular Cancer Completed NCT03426865 Phase 2 Axumin PET scan
2 A Phase I Study of Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Escalating Doses of Cisplatin for Children With Peritoneal Carcinomatosis or Advanced Peritoneal and Retroperitoneal Disease Completed NCT00436657 Phase 1 CHPP of Cisplatin
3 A Phase 1B Trial of Preoperative Eribulin and Radiation for Retroperitoneal Liposarcoma Recruiting NCT03361436 Phase 1 Eribulin Mesylate
4 Phase Ib Clinical Investigation of Intraperitoneal Ipilimumab and Nivolumab in Patients With Peritoneal Carcinomatosis Due to Gynecologic Cancers Recruiting NCT03508570 Phase 1
5 Long Term Morbidity and Quality of Life After Multivisceral Resection for Primary Retroperitoneal Soft Tissue Sarcomas: a Prospective Observational Study Active, not recruiting NCT03480399

Search NIH Clinical Center for Retroperitoneum Carcinoma

Cochrane evidence based reviews: retroperitoneal neoplasms

Genetic Tests for Retroperitoneum Carcinoma

Anatomical Context for Retroperitoneum Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Retroperitoneum Carcinoma:

19
Retroperitoneal Space

MalaCards organs/tissues related to Retroperitoneum Carcinoma:

40
Lymph Node, Kidney

Publications for Retroperitoneum Carcinoma

Articles related to Retroperitoneum Carcinoma:

(show all 15)
# Title Authors PMID Year
1
Feasibility and Safety of Laparoscopic Radical Distal Pancreatosplenectomy with Adrenalectomy in Advanced Pancreatic Cancer. 61
32474822 2020
2
Spinal Extradural Arteriovenous Fistula with Cowden Syndrome: A Case Report and Literature Review Regarding Pathogenesis and Therapeutic Strategy. 61
30327747 2018
3
Tubular Compressed Collagen Scaffolds for Ureteral Tissue Engineering in a Flow Bioreactor System. 61
26065873 2015
4
[Retroperitoneal fibrosis associated with malignancies: report of eight cases]. 61
25327326 2014
5
The hot foot syndrome: Evans' sign and the old way. 61
22518365 2012
6
Serous adenocarcinoma of the retroperitoneum, as a type of multifocal müllerian carcinoma. 61
19593619 2009
7
Preoperative chemotherapy with irinotecan and mitomycin for FIGO stage IIIb cervical squamous cell carcinoma: a pilot study. 61
16398218 2005
8
Mortality of Sardinian lead and zinc miners: 1960-88. 61
8000492 1994
9
[The role of ultrasonics in the detection of metastatic tumors of abdominal organs]. 61
1808408 1991
10
An experimental study of hot air thermocoagulation in cardiac surgery. 61
1756048 1991
11
Surgical approaches and techniques in intraoperative radiotherapy for intra-abdominal, retroperitoneal, and pelvic neoplasms. 61
3124281 1988
12
Radical retroperitoneal tumor surgery with resection of the psoas major muscle. 61
4016684 1985
13
Is age alone a contraindication to major cancer surgery? 61
2410090 1985
14
Second-look operation for retroperitoneal cancer in childhood. 61
5277491 1971
15
[Dislocation of the kid kidneys & ureters in retroperitoneal cancer]. 61
13490634 1957

Variations for Retroperitoneum Carcinoma

Expression for Retroperitoneum Carcinoma

Search GEO for disease gene expression data for Retroperitoneum Carcinoma.

Pathways for Retroperitoneum Carcinoma

GO Terms for Retroperitoneum Carcinoma

Biological processes related to Retroperitoneum Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.62 PTPRC MDM2 F2 CDK4
2 positive regulation of gene expression GO:0010628 9.35 WT1 MDM2 KIT CDKN2A CD34
3 amyloid fibril formation GO:1990000 9.26 MDM2 CDKN2A
4 somatic stem cell division GO:0048103 9.16 KIT CDKN2A
5 positive regulation of cell proliferation GO:0008284 9.1 RPRD1B PRAMEF14 MDM2 KIT F2 CDK4

Molecular functions related to Retroperitoneum Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SUMO transferase activity GO:0019789 8.62 MDM2 CDKN2A

Sources for Retroperitoneum Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....