MCID: RTR017
MIFTS: 7

Retrovirus-Associated Myelopathy

Aliases & Classifications for Retrovirus-Associated Myelopathy

MalaCards integrated aliases for Retrovirus-Associated Myelopathy:

Name: Retrovirus-Associated Myelopathy 53

Summaries for Retrovirus-Associated Myelopathy

NINDS : 53 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Retrovirus-Associated Myelopathy is related to myelopathy, htlv-1-associated and adult t-cell leukemia. Affiliated tissues include t cells, eye and lung.

Wikipedia : 74 Tropical spastic paraparesis (TSP), is a medical condition that causes weakness, muscle spasms, and... more...

Related Diseases for Retrovirus-Associated Myelopathy

Diseases related to Retrovirus-Associated Myelopathy via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 myelopathy, htlv-1-associated 10.0
2 adult t-cell leukemia 10.0
3 tropical spastic paraparesis 10.0
4 t-cell adult acute lymphocytic leukemia 10.0
5 t-cell leukemia 10.0
6 htlv-1 associated myelopathy/tropical spastic paraparesis 10.0
7 spastic paraparesis 10.0

Graphical network of the top 20 diseases related to Retrovirus-Associated Myelopathy:



Diseases related to Retrovirus-Associated Myelopathy

Symptoms & Phenotypes for Retrovirus-Associated Myelopathy

Drugs & Therapeutics for Retrovirus-Associated Myelopathy

Search Clinical Trials , NIH Clinical Center for Retrovirus-Associated Myelopathy

Genetic Tests for Retrovirus-Associated Myelopathy

Anatomical Context for Retrovirus-Associated Myelopathy

MalaCards organs/tissues related to Retrovirus-Associated Myelopathy:

40
T Cells, Eye, Lung, Breast, Skin

Publications for Retrovirus-Associated Myelopathy

Articles related to Retrovirus-Associated Myelopathy:

# Title Authors PMID Year
1
The role of HTLV-I in tropical spastic paraparesis in Jamaica. 61
2894801 1988

Variations for Retrovirus-Associated Myelopathy

Expression for Retrovirus-Associated Myelopathy

Search GEO for disease gene expression data for Retrovirus-Associated Myelopathy.

Pathways for Retrovirus-Associated Myelopathy

GO Terms for Retrovirus-Associated Myelopathy

Sources for Retrovirus-Associated Myelopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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