MCID: RTR017
MIFTS: 6

Retrovirus-Associated Myelopathy

Categories: Immune diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Retrovirus-Associated Myelopathy

MalaCards integrated aliases for Retrovirus-Associated Myelopathy:

Name: Retrovirus-Associated Myelopathy 55

Classifications:



Summaries for Retrovirus-Associated Myelopathy

NINDS : 55 For several decades the term “tropical spastic paraparesis” (TSP) has been used to describe a chronic and progressive disease of the nervous system that affects adults living in equatorial areas of the world and causes progressive weakness, stiff muscles, muscle spasms, sensory disturbance, and sphincter dysfunction. The cause of TSP was obscure until the mid-1980s, when an important association was established between the human retrovirus — human T-cell lymphotrophic virus type 1 (also known as HTLV-1) — and TSP. TSP is now called HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP. The HTLV-1 retrovirus is thought to cause at least 80 percent of the cases of HAM/TSP by impairing the immune system. In addition to neurological symptoms of weakness and muscle stiffness or spasms, in rare cases individuals with HAM/TSP also exhibit uveitis (inflammation of the uveal tract of the eye), arthritis (inflammation of one or more joints), pulmonary lymphocytic alveolitis (inflammation of the lung), polymyositis (an inflammatory muscle disease), keratoconjunctivitis sicca (persistent dryness of the cornea and conjunctiva), and infectious dermatitis (inflammation of the skin). The other serious complication of HTLV-1 infection is the development of adult T-cell leukemia or lymphoma. Nervous system and blood-related complications occur only in a very small proportion of infected individuals, while most remain largely without symptoms throughout their lives. The HTLV-1 virus is transmitted person-to-person via infected cells: breast-feeding by mothers who are seropositive (in other words, have high levels of virus antibodies in their blood), sharing infected needles during intravenous drug use, or having sexual relations with a seropositive partner. Less than 2 percent of HTLV-1 seropositive carriers will become HAM/TSP patients.

MalaCards based summary : Retrovirus-Associated Myelopathy Affiliated tissues include skin, eye and t cells.

Wikipedia : 77 Tropical spastic paraparesis (TSP), also called HTLV-I-associated myelopathy (HAM) or HTLV-I-associated... more...

Related Diseases for Retrovirus-Associated Myelopathy

Symptoms & Phenotypes for Retrovirus-Associated Myelopathy

Drugs & Therapeutics for Retrovirus-Associated Myelopathy

Search Clinical Trials , NIH Clinical Center for Retrovirus-Associated Myelopathy

Genetic Tests for Retrovirus-Associated Myelopathy

Anatomical Context for Retrovirus-Associated Myelopathy

MalaCards organs/tissues related to Retrovirus-Associated Myelopathy:

42
Skin, Eye, T Cells

Publications for Retrovirus-Associated Myelopathy

Variations for Retrovirus-Associated Myelopathy

Expression for Retrovirus-Associated Myelopathy

Search GEO for disease gene expression data for Retrovirus-Associated Myelopathy.

Pathways for Retrovirus-Associated Myelopathy

GO Terms for Retrovirus-Associated Myelopathy

Sources for Retrovirus-Associated Myelopathy

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
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47 MGI
50 NCI
51 NCIt
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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