MCID: RVR002
MIFTS: 29

Reversible Cerebral Vasoconstriction Syndrome

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Reversible Cerebral Vasoconstriction Syndrome

MalaCards integrated aliases for Reversible Cerebral Vasoconstriction Syndrome:

Name: Reversible Cerebral Vasoconstriction Syndrome 54 60 74
Rcvs 54 60

Characteristics:

Orphanet epidemiological data:

60
reversible cerebral vasoconstriction syndrome
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

ICD10 via Orphanet 35 I67.8
UMLS via Orphanet 75 C3544214
Orphanet 60 ORPHA284388
UMLS 74 C3544214

Summaries for Reversible Cerebral Vasoconstriction Syndrome

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 284388Disease definitionReversible cerebral vasoconstriction syndrome (RCVS) is an infrequent cerebrovascular disorder characterized by severe headaches with or without focal neurological deficits or seizures, and a reversible segmental and multifocal vasoconstriction of cerebral arteries.EpidemiologyRCVS occurs predominantly in females before the age of 50.Clinical descriptionThe most common clinical feature of RCVS is severe acute headache. The major complication of RCVS is ischemic or hemorrhagic stroke.EtiologyThe exact pathophysiology of RCVS remains unknown and the prevailing hypothesis involves a transient disturbance in the control of cerebral vascular tone. RCVS may occur spontaneously or be provoked by various precipitating factors, the most common being postpartum and exposure to various vasoactive substances such as illicit drugs and selective serotonin-reuptake inhibitors.Visit the Orphanet disease page for more resources.

MalaCards based summary : Reversible Cerebral Vasoconstriction Syndrome, also known as rcvs, is related to headache and thunderclap headache. The drugs Verapamil and Nimodipine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and endothelial.

Wikipedia : 77 Reversible cerebral vasoconstriction syndrome (RCVS, sometimes called Call-Fleming syndrome) is a... more...

Related Diseases for Reversible Cerebral Vasoconstriction Syndrome

Diseases related to Reversible Cerebral Vasoconstriction Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 headache 10.7
2 thunderclap headache 10.5
3 encephalopathy 10.5
4 stroke, ischemic 10.4
5 systemic lupus erythematosus 10.3
6 lupus erythematosus 10.3
7 vasculitis 10.2
8 primary angiitis of the central nervous system 10.2
9 seizure disorder 10.2
10 multiple sclerosis 10.1
11 hemorrhage, intracerebral 10.1
12 acute lymphocytic leukemia 10.1
13 leukemia 10.1
14 lymphocytic leukemia 10.1
15 eclampsia 10.1
16 central nervous system vasculitis 10.1
17 carotid artery dissection 10.1
18 intracranial hypertension 10.1
19 disease of mental health 10.0
20 eosinophilia-myalgia syndrome 10.0
21 new daily-persistent headache 10.0
22 breast cancer 9.9
23 hypertension, essential 9.9
24 migraine with or without aura 1 9.9
25 thrombophilia due to thrombin defect 9.9
26 schimke immunoosseous dysplasia 9.9
27 thrombotic thrombocytopenic purpura, congenital 9.9
28 aplastic anemia 9.9
29 malaria 9.9
30 leukemia, acute lymphoblastic 9.9
31 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.9
32 deficiency anemia 9.9
33 arteriovenous fistula 9.9
34 hemangioma 9.9
35 loeys-dietz syndrome 9.9
36 paraganglioma 9.9
37 lymphoma 9.9
38 thrombosis 9.9
39 pre-eclampsia 9.9
40 thrombotic thrombocytopenic purpura 9.9
41 amnestic disorder 9.9
42 pituitary apoplexy 9.9
43 guillain-barre syndrome 9.9
44 transient global amnesia 9.9
45 relapsing-remitting multiple sclerosis 9.9
46 antiphospholipid syndrome 9.9
47 ischemia 9.9
48 purpura 9.9
49 intracranial hypotension 9.9
50 cavernous hemangioma 9.9

Graphical network of the top 20 diseases related to Reversible Cerebral Vasoconstriction Syndrome:



Diseases related to Reversible Cerebral Vasoconstriction Syndrome

Symptoms & Phenotypes for Reversible Cerebral Vasoconstriction Syndrome

Drugs & Therapeutics for Reversible Cerebral Vasoconstriction Syndrome

Drugs for Reversible Cerebral Vasoconstriction Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 4 52-53-9 2520
2
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
3
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
4 Calcium, Dietary Phase 4
5 Anti-Arrhythmia Agents Phase 4
6 Antihypertensive Agents Phase 4
7 Hormones Phase 4
8 Vasodilator Agents Phase 4
9 calcium channel blockers Phase 4
10 Immunoglobulins
11 Immunologic Factors
12 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 RCVS: The Rational Approach to Diagnosis and Treatment Recruiting NCT03150524 Phase 4 Nimodipine;Verapamil ER
2 Perfusion MRI in Reversible Cerebral Vasoconstriction Syndrome Unknown status NCT02756416 Not Applicable
3 Reversible Cerebral Vasoconstriction Syndrome With Concomitant Transient Global Amnesia Completed NCT03739008
4 Retinal Patterns in Reversible Cerebral Vasoconstriction Syndrome Completed NCT03204110
5 Reversible Cerebral Vasoconstriction Syndrome and Varicella Zoster Virus Recruiting NCT03509701
6 Intracranial Artery Stenosis Magnetic Resonance Imaging: Aetiology and Progression Recruiting NCT03417063

Search NIH Clinical Center for Reversible Cerebral Vasoconstriction Syndrome

Genetic Tests for Reversible Cerebral Vasoconstriction Syndrome

Anatomical Context for Reversible Cerebral Vasoconstriction Syndrome

MalaCards organs/tissues related to Reversible Cerebral Vasoconstriction Syndrome:

42
Brain, Testes, Endothelial, Kidney, Bone, Pituitary, Bone Marrow

Publications for Reversible Cerebral Vasoconstriction Syndrome

Articles related to Reversible Cerebral Vasoconstriction Syndrome:

(show top 50) (show all 577)
# Title Authors Year
1
A case of reversible cerebral vasoconstriction syndrome developing during treatment of adult aplastic anemia. ( 29987351 )
2019
2
Posterior reversible encephalopathy syndrome associated with reversible cerebral vasoconstriction syndrome in a patient presenting with postpartum eclampsia: a case report. ( 30905853 )
2019
3
Teaching Images in Headache: Concurrent Hypercalcemia-Induced Reversible Cerebral Vasoconstriction Syndrome and Posterior Reversible Encephalopathy Syndrome. ( 30985912 )
2019
4
Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome after Rapid Blood Transfusion. ( 30996159 )
2019
5
A systemic lupus erythematosus patient with thunderclap headache: reversible cerebral vasoconstriction syndrome. ( 31042127 )
2019
6
An RCVS Spectrum Disorder? New Daily Persistent Headache Starting as a Single Thunderclap Headache (3 New Cases). ( 30830966 )
2019
7
Decompression Hemicraniectomy for Refractory Intracranial Hypertension in Reversible Cerebral Vasoconstriction Syndrome. ( 31001036 )
2019
8
Reversible cerebral vasoconstriction syndrome in paediatric patients with systemic lupus erythematosus: implications for management. ( 30246466 )
2019
9
A Case of Reversible Cerebral Vasoconstriction Syndrome Triggered by High-Dose Methotrexate in a Boy With Lymphoma. ( 30985924 )
2019
10
Dangerous manifestations of reversible cerebral vasoconstriction syndrome. ( 29936008 )
2019
11
Reversible cerebral vasoconstriction syndrome: a rare arteriopathy of childhood. ( 30341766 )
2019
12
Reversible Cerebral Vasoconstriction Syndrome after Administering Etanercept during Puerperium. ( 30630756 )
2019
13
Reversible Cerebral Vasoconstriction Syndrome: A Novel Mechanism for Neurological Complications in Schimke Immuno-osseous Dysplasia. ( 30635151 )
2019
14
RCVS2 score and diagnostic approach for reversible cerebral vasoconstriction syndrome. ( 30635475 )
2019
15
The clinical spectrum of reversible cerebral vasoconstriction syndrome: The Italian Project on Stroke at Young Age (IPSYS). ( 31060368 )
2019
16
MRA and ASL perfusion findings in pediatric reversible cerebral vasoconstriction syndrome. ( 31061686 )
2019
17
Intracranial arteriopathies and RCVS: A discriminatory clinical tool. ( 30635492 )
2019
18
'Should we test new grads?' asks RCVS. ( 30635522 )
2019
19
2018 is record year for RCVS disciplinaries. ( 30655392 )
2019
20
RCVS delays vote on voting. ( 30683779 )
2019
21
RCVS President, Amanda Boag, responds. ( 30733363 )
2019
22
Will the RCVS accredit Indian vet schools? ( 30765572 )
2019
23
Transparent RCVS voting. ( 30792333 )
2019
24
Lizzie Lockett, Chief Executive of the RCVS, responds. ( 30792334 )
2019
25
Influence of Climate on the Incidence of RCVS - A Retrospective Study From Taiwan. ( 30866069 )
2019
26
Amanda Boag, RCVS president, responds. ( 30872446 )
2019
27
RCVS heads to India again for accreditation talks. ( 30902935 )
2019
28
RCVS in talks with paraprofessionals for regulation. ( 30926693 )
2019
29
RCVS announces its 2019 award winners. ( 30948657 )
2019
30
Chris Tufnell, RCVS Lead on Global Strategy, responds. ( 30975847 )
2019
31
RCVS mediation service working well. ( 31048515 )
2019
32
Reversible Cerebral Vasoconstriction Syndrome as an Unusual Complication of a Dural Arteriovenous Fistula treated with Onyx Embolization. ( 29751188 )
2018
33
A case of reversible cerebral vasoconstriction syndrome and cavernous hemangioma: just a coincidence? ( 30062645 )
2018
34
Cough Headache Presenting with Reversible Cerebral Vasoconstriction Syndrome. ( 29321411 )
2018
35
Reversible Cerebral Vasoconstriction Syndrome following Guillain-Barré Syndrome: A Rare Complication. ( 30203802 )
2018
36
A headache-free reversible cerebral vasoconstriction syndrome (RCVS) with symptomatic brain stem ischemia at late pregnancy as a rare manifestation of RCVS resolved with termination of pregnancy by semi-urgent cesarean section. ( 30487987 )
2018
37
Triptan-induced Reversible Cerebral Vasoconstriction Syndrome Presenting With Thunderclap Headache and Paraparesis. ( 30169369 )
2018
38
Case Report: Reversible Cerebral Vasoconstriction Syndrome in Cerebral Malaria. ( 29260652 )
2018
39
Reversible cerebral vasoconstriction syndrome. ( 27915588 )
2018
40
Reversible cerebral vasoconstriction syndrome secondary to caffeine withdrawal. ( 28480791 )
2018
41
Characteristics and demographics of reversible cerebral vasoconstriction syndrome: A large prospective series of Korean patients. ( 28592180 )
2018
42
Isoflavones and gastrointestinal infection: Two potential triggers for reversible cerebral vasoconstriction syndrome. ( 28610434 )
2018
43
Reversible cerebral vasoconstriction syndrome: an important non-aneurysmal cause of thunderclap headaches and subarachnoid hemorrhage. ( 28779450 )
2018
44
Isolated cortical vasogenic edema and hyperintense vessel signs may be early features of reversible cerebral vasoconstriction syndrome: Case reports. ( 28906126 )
2018
45
Serial testing of the ICHD-3 beta diagnostic criteria for probable reversible cerebral vasoconstriction syndrome: A prospective validation study. ( 29160084 )
2018
46
Reversible cerebral vasoconstriction syndrome: an important and common cause of thunderclap and recurrent headaches. ( 29274685 )
2018
47
Fulminant Reversible Cerebral Vasoconstriction Syndrome. ( 29276569 )
2018
48
Fatal reversible cerebral vasoconstriction syndrome. ( 29406896 )
2018
49
Reversible cerebral vasoconstriction syndrome accompanied by hypomagnesemia. ( 29455396 )
2018
50
Clinical significance of centripetal propagation of vasoconstriction in patients with reversible cerebral vasoconstriction syndrome: A retrospective case-control study. ( 29495882 )
2018

Variations for Reversible Cerebral Vasoconstriction Syndrome

Expression for Reversible Cerebral Vasoconstriction Syndrome

Search GEO for disease gene expression data for Reversible Cerebral Vasoconstriction Syndrome.

Pathways for Reversible Cerebral Vasoconstriction Syndrome

GO Terms for Reversible Cerebral Vasoconstriction Syndrome

Sources for Reversible Cerebral Vasoconstriction Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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