RS
MCID: RYS001
MIFTS: 54

Reye Syndrome (RS)

Categories: Bone diseases, Gastrointestinal diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Reye Syndrome

MalaCards integrated aliases for Reye Syndrome:

Name: Reye Syndrome 12 53 59 55 43 44 15 73
Reye's Syndrome 12 76 53 54
Fatty Liver with Encephalopathy 53
Rs 53

Classifications:



External Ids:

Disease Ontology 12 DOID:14525
ICD10 33 G93.7 K76.0
ICD9CM 35 331.81
MeSH 44 D012202
NCIt 50 C34983
SNOMED-CT 68 74351001
Orphanet 59 ORPHA3096
MESH via Orphanet 45 D012202
UMLS via Orphanet 74 C0035400
ICD10 via Orphanet 34 G93.7
UMLS 73 C0035400

Summaries for Reye Syndrome

NINDS : 54 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards based summary : Reye Syndrome, also known as reye's syndrome, is related to citrullinemia, classic and severe combined immunodeficiency with sensitivity to ionizing radiation, and has symptoms including seizures, tremor and back pain. An important gene associated with Reye Syndrome is HMGCL (3-Hydroxy-3-Methylglutaryl-CoA Lyase), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Affiliated tissues include liver, brain and kidney, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use.

MedlinePlus : 43 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include Nausea and vomiting Listlessness Personality change - such as irritability, combativeness or confusion Delirium Convulsions Loss of consciousness If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure. The cause of Reye syndrome is unknown. Studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 Reye syndrome is a rapidly progressive encephalopathy. Symptoms may include vomiting, personality... more...

Related Diseases for Reye Syndrome

Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 citrullinemia, classic 29.8 ASS1 OTC
2 severe combined immunodeficiency with sensitivity to ionizing radiation 11.8
3 lymphoma, hodgkin, classic 11.5
4 retinoschisis 1, x-linked, juvenile 11.4
5 chickenpox 11.4
6 myelodysplastic syndrome 11.3
7 roberts syndrome 11.0
8 lymphoma, hodgkin, x-linked pseudoautosomal 11.0
9 richter's syndrome 11.0
10 influenza 10.2
11 encephalopathy 10.2
12 acyl-coa dehydrogenase, medium-chain, deficiency of 10.1 ACADM HADHA
13 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.1 ACADM HADHA
14 postpartum psychosis 10.1 ASS1 OTC
15 carbamoyl phosphate synthetase i deficiency, hyperammonemia due to 10.1 ASS1 OTC
16 carbonic anhydrase va deficiency, hyperammonemia due to 10.1 ASS1 OTC
17 urea cycle disorder 10.1 ASS1 OTC
18 argininemia 10.1 ASS1 OTC
19 ornithine transcarbamylase deficiency, hyperammonemia due to 10.1 ASS1 OTC
20 orotic aciduria 10.1 ASS1 OTC
21 fabry disease 10.1
22 neurotic disorder 10.1
23 argininosuccinic aciduria 10.1 ASS1 OTC
24 hyperlysinemia, type i 10.0 OTC PC
25 3-hydroxyacyl-coa dehydrogenase deficiency 10.0 ACADM HADHA OTC
26 phenylketonuria 10.0 ACADM HADHA OTC
27 acyl-coa dehydrogenase, very long-chain, deficiency of 10.0 HADHA HMGCL
28 maple syrup urine disease 10.0 HADHA HMGCL OTC
29 propionic acidemia 10.0 ASS1 HMGCL OTC
30 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 10.0 OAT OTC
31 coffin-lowry syndrome 10.0
32 keratosis follicularis spinulosa decalvans, autosomal dominant 10.0
33 japanese encephalitis 10.0
34 multiple carboxylase deficiency 10.0 ACADM OTC PC
35 organic acidemia 9.9 ACADM HMGCL
36 methylmalonic aciduria due to methylmalonyl-coa mutase deficiency 9.9 HMGCL OTC PC
37 kawasaki disease 9.9
38 connective tissue disease 9.9
39 viral infectious disease 9.9
40 alzheimer disease 9.9
41 colorectal cancer 9.9
42 attention deficit-hyperactivity disorder 9.9
43 ovarian cancer 9.9
44 schizophrenia 9.9
45 microvascular complications of diabetes 3 9.9
46 microvascular complications of diabetes 4 9.9
47 microvascular complications of diabetes 6 9.9
48 microvascular complications of diabetes 7 9.9
49 squamous cell carcinoma 9.9
50 hepatitis c 9.9

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to Reye Syndrome

Symptoms & Phenotypes for Reye Syndrome

UMLS symptoms related to Reye Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Reye Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 ASS1 HADHA HMGCL HMGCR OAT OTC
2 homeostasis/metabolism MP:0005376 9.81 ACADM ASS1 CES1 HADHA HMGCL HMGCR
3 liver/biliary system MP:0005370 9.5 ACADM CES1 HADHA HMGCL HMGCR OTC
4 mortality/aging MP:0010768 9.23 ACADM ASS1 HADHA HMGCL HMGCR OAT

Drugs & Therapeutics for Reye Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intracranial Hypertension and Optic Nerve Sheath Diameter Completed NCT01796015 Not Applicable

Search NIH Clinical Center for Reye Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: reye syndrome

Genetic Tests for Reye Syndrome

Anatomical Context for Reye Syndrome

MalaCards organs/tissues related to Reye Syndrome:

41
Liver, Brain, Kidney, Bone, Skin, Lung, Thyroid

Publications for Reye Syndrome

Articles related to Reye Syndrome:

(show top 50) (show all 962)
# Title Authors Year
1
Co-ingestion of aspirin and acetaminophen promoting fulminant liver failure: A critical review of Reye syndrome in the current perspective at the dawn of the 21st century. ( 28945927 )
2018
2
Carnitine palmitoyltransferase 1A deficiency: abnormal muscle biopsy findings in a child presenting with Reye's syndrome. ( 28466427 )
2017
3
Impact of fatty acid oxidation disorders in child neurology: from Reye syndrome to Pandora's box. ( 25761966 )
2015
4
Resveratrol protects against experimental induced Reye's syndrome by prohibition of oxidative stress and restoration of complex I activity. ( 25162205 )
2014
5
Hyponatremic seizures and Reye syndrome. ( 23829993 )
2013
6
Did the patient have Reye syndrome? ( 21980824 )
2011
7
Magnetic resonance imaging findings in Reye syndrome: case report and review of the literature. ( 21633106 )
2011
8
Fatal case of Reye's syndrome associated with H3N2 influenza virus infection and salicylate intake in a 12-year-old patient. ( 20167009 )
2011
9
Have the efforts to prevent aspirin-related Reye's syndrome fuelled an increase in asthma? ( 21294782 )
2011
10
Acute encephalopathy of Bacillus cereus mimicking Reye syndrome. ( 19796886 )
2010
11
Reye syndrome and liver transplantation. ( 21428204 )
2010
12
Salicylate oral gel: Reye's syndrome. ( 20740719 )
2010
13
Kids versus trees: Reye's syndrome and spraying for spruce budworm in New Brunswick. ( 19345558 )
2009
14
Reye syndrome: a case report with review of literature. ( 18552890 )
2008
15
Reye syndrome and reye-like syndrome. ( 18725066 )
2008
16
Aspirin and Reye syndrome. ( 17523701 )
2007
17
Aspirin and Reye syndrome: a review of the evidence. ( 17523700 )
2007
18
The thalamus and midbrain in Reye syndrome. ( 16648004 )
2006
19
Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. ( 16254043 )
2006
20
A case of Reye syndrome with rotavirus infection accompanied with high cytokines. ( 16226809 )
2006
21
Reye's syndrome: the case for a causal link with aspirin. ( 17147458 )
2006
22
Reye's syndrome developing in an infant on treatment of Kawasaki syndrome. ( 15953335 )
2005
23
Aspirin, Reye syndrome, Kawasaki disease, and allergies; a reconsideration of the links. ( 15557065 )
2004
24
Is aspirin a cause of Reye's syndrome? ( 14720087 )
2004
25
"African medicine" and Reye's syndrome. ( 15031031 )
2004
26
Reassessing Reye syndrome. ( 14662583 )
2003
27
Reye syndrome. ( 12865641 )
2003
28
[Reye syndrome and drug induced encephalopathy]. ( 15152490 )
2003
29
Reye's syndrome: down but not out. ( 12602712 )
2003
30
Reye's syndrome. ( 12693474 )
2003
31
Labeling for oral and rectal over-the-counter drug products containing aspirin and nonaspirin salicylates; Reye's Syndrome warning. Final rule. ( 12701599 )
2003
32
The isoprenoid pathway and the pathogenesis of Reye's syndrome. ( 14692194 )
2003
33
Reye's syndrome. ( 16388216 )
2003
34
Rotavirus, hepatitis and Reye syndrome. ( 12354277 )
2002
35
Important role of prodromal viral infections responsible for inhibition of xenobiotic metabolizing enzymes in the pathomechanism of idiopathic Reye's syndrome, Stevens-Johnson syndrome, autoimmune hepatitis, and hepatotoxicity of the therapeutic doses of acetaminophen used in genetically predisposed persons. ( 11897929 )
2002
36
Reye's syndrome revisited. Outdated concept of Reye's syndrome was used. ( 11872565 )
2002
37
Is aspirin a cause of Reye's syndrome? A case against. ( 11994026 )
2002
38
Aspirin and Reye's syndrome: is the response appropriate? ( 12081628 )
2002
39
Aspirin and Reye's syndrome: discovery of aspirin and paracetamol. ( 12167070 )
2002
40
Reye's syndrome in a 17-year-old male: is this disease really disappearing? ( 12353836 )
2002
41
A fatal case of Reye syndrome after varicella and ingestion of aspirin. ( 11436370 )
2001
42
Reye syndrome--insights on causation and prognosis. ( 11668090 )
2001
43
Salicylates, nitric oxide, malaria, and Reye's syndrome. ( 11417574 )
2001
44
Lesson of the week: Reye's syndrome and aspirin: lest we forget. ( 11431304 )
2001
45
Incidence of Reye's syndrome in France: a hospital-based survey. ( 11470397 )
2001
46
Reye's syndrome. ( 11501538 )
2001
47
Rotavirus gastroenteritis possibly causing reye syndrome. ( 10852203 )
2000
48
Reye syndrome revisited: a descriptive term covering a group of heterogeneous disorders. ( 11014461 )
2000
49
Experimental models of Reye's syndrome. ( 10977933 )
2000
50
Epidemiology of Reye's syndrome, United States, 1991-1994: comparison of CDC surveillance and hospital admission data. ( 11060509 )
2000

Variations for Reye Syndrome

Expression for Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for Reye Syndrome

Pathways related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 ACADM ASS1 CES1 HADHA HMGCL HMGCR
2
Show member pathways
12.49 ACADM HADHA HMGCL HMGCR SCD
3
Show member pathways
11.71 ACADM HADHA HMGCL
4
Show member pathways
11.68 ACADM ASS1 HADHA OTC PC
5
Show member pathways
11.51 ACADM HADHA SCD
6 11.45 HMGCR SCD
7
Show member pathways
11.4 ACADM HADHA
8
Show member pathways
11.29 HADHA SCD
9
Show member pathways
11.28 ACADM HADHA
10
Show member pathways
11.13 HADHA HMGCL
11
Show member pathways
11.07 ACADM HADHA
12 11.06 ACADM ASS1 HMGCL OAT OTC PC
13 11.03 ACADM HADHA
14
Show member pathways
10.93 ASS1 OTC
15 10.84 PC SCD
16
Show member pathways
10.81 ASS1 OAT OTC
17 10.76 HMGCR SCD
18
Show member pathways
10.55 ASS1 PC
19
Show member pathways
10.4 ACADM HADHA

GO Terms for Reye Syndrome

Cellular components related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.5 ACADM ASS1 HADHA HMGCL OAT OTC
2 mitochondrial matrix GO:0005759 9.02 ACADM HMGCL OAT OTC PC

Biological processes related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.86 ACADM HADHA HMGCR SCD
2 response to drug GO:0042493 9.75 ASS1 HADHA OTC
3 fatty acid metabolic process GO:0006631 9.65 ACADM HADHA SCD
4 response to insulin GO:0032868 9.58 HADHA OTC
5 liver development GO:0001889 9.58 ASS1 HMGCL OTC
6 fatty acid beta-oxidation GO:0006635 9.57 ACADM HADHA
7 cholesterol biosynthetic process GO:0006695 9.55 CES1 HMGCR
8 response to starvation GO:0042594 9.54 ACADM HMGCL
9 response to nutrient GO:0007584 9.54 ASS1 HMGCL HMGCR
10 protein tetramerization GO:0051262 9.52 HMGCL HMGCR
11 regulation of cholesterol biosynthetic process GO:0045540 9.51 HMGCR SCD
12 response to zinc ion GO:0010043 9.49 ASS1 OTC
13 urea cycle GO:0000050 9.46 ASS1 OTC
14 midgut development GO:0007494 9.43 ASS1 OTC
15 cellular amino acid biosynthetic process GO:0008652 9.33 ASS1 OAT OTC
16 arginine biosynthetic process GO:0006526 9.32 ASS1 OTC
17 medium-chain fatty acid metabolic process GO:0051791 9.26 ACADM CES1
18 response to fatty acid GO:0070542 9.13 ASS1 HMGCL SCD
19 lipid metabolic process GO:0006629 9.1 ACADM HADHA HMGCL HMGCR PC SCD

Molecular functions related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.46 ACADM HADHA HMGCR SCD
2 catalytic activity GO:0003824 9.43 HADHA HMGCL PC
3 amino acid binding GO:0016597 8.96 ASS1 OTC
4 fatty-acyl-CoA binding GO:0000062 8.62 HADHA HMGCL

Sources for Reye Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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