MCID: RYS001
MIFTS: 49

Reye Syndrome

Categories: Rare diseases, Neuronal diseases, Gastrointestinal diseases, Bone diseases, Liver diseases

Aliases & Classifications for Reye Syndrome

MalaCards integrated aliases for Reye Syndrome:

Name: Reye Syndrome 12 53 59 55 43 44 15 73
Reye's Syndrome 12 76 53 54
Fatty Liver with Encephalopathy 53
Rs 53

Classifications:



External Ids:

Disease Ontology 12 DOID:14525
ICD10 33 G93.7 K76.0
ICD9CM 35 331.81
MeSH 44 D012202
NCIt 50 C34983
Orphanet 59 ORPHA3096
MESH via Orphanet 45 D012202
UMLS via Orphanet 74 C0035400
ICD10 via Orphanet 34 G93.7
UMLS 73 C0035400

Summaries for Reye Syndrome

NINDS : 54 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards based summary : Reye Syndrome, also known as reye's syndrome, is related to citrullinemia, classic and severe combined immunodeficiency with sensitivity to ionizing radiation, and has symptoms including back pain, headache and pain. An important gene associated with Reye Syndrome is HMGCL (3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Affiliated tissues include liver, brain and skin, and related phenotypes are growth/size/body region and homeostasis/metabolism

MedlinePlus : 43 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include Nausea and vomiting Listlessness Personality change - such as irritability, combativeness or confusion Delirium Convulsions Loss of consciousness If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure. The cause of Reye syndrome is unknown. Studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients. NIH: National Institute of Neurological Disorders and Stroke

Disease Ontology : 12 A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use.

Wikipedia : 76 Reye syndrome is a rapidly progressive encephalopathy. Symptoms may include vomiting, personality... more...

Related Diseases for Reye Syndrome

Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 citrullinemia, classic 29.3 ASS1 OTC
2 severe combined immunodeficiency with sensitivity to ionizing radiation 11.6
3 lymphoma, hodgkin, classic 11.3
4 retinoschisis 1, x-linked, juvenile 11.2
5 chickenpox 11.2
6 myelodysplastic syndrome 11.2
7 roberts syndrome 10.9
8 lymphoma, hodgkin, x-linked pseudoautosomal 10.9
9 richter's syndrome 10.9
10 acyl-coa dehydrogenase, medium-chain, deficiency of 10.4 ACADM HADHA
11 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.4 ACADM HADHA
12 hyperlysinemia, type i 10.3 OTC PC
13 influenza 10.1
14 3-hydroxyacyl-coa dehydrogenase deficiency 10.1 ACADM HADHA OTC
15 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 10.1 OAT OTC
16 acyl-coa dehydrogenase, very long-chain, deficiency of 10.1 HADHA HMGCL
17 phenylketonuria 10.1 ACADM HADHA OTC
18 hepatitis 10.1
19 encephalopathy 10.1
20 organic acidemia 10.1 ACADM HMGCL
21 multiple carboxylase deficiency 10.0 ACADM OTC PC
22 postpartum psychosis 9.9 ASS1 OTC
23 methylmalonic aciduria, cblb type 9.9 HMGCL OTC PC
24 carbamoyl phosphate synthetase i deficiency, hyperammonemia due to 9.9 ASS1 OTC
25 cerebritis 9.9
26 carbonic anhydrase va deficiency, hyperammonemia due to 9.9 ASS1 OTC
27 lymphoma 9.9
28 argininemia 9.8 ASS1 OTC
29 kawasaki disease 9.8
30 connective tissue disease 9.8
31 type i 9.8
32 urea cycle disorder 9.8 ASS1 OTC
33 alzheimer disease 9.8
34 colorectal cancer 9.8
35 ovarian cancer 9.8
36 schizophrenia 9.8
37 fabry disease 9.8
38 ornithine transcarbamylase deficiency, hyperammonemia due to 9.8 ASS1 OTC
39 argininosuccinic aciduria 9.7 ASS1 OTC
40 orotic aciduria 9.7 ASS1 OTC
41 systemic lupus erythematosus 9.7
42 rheumatoid arthritis 9.7
43 sudden infant death syndrome 9.7
44 fatty liver disease, nonalcoholic 1 9.7
45 plasma fibronectin deficiency 9.7
46 infantile liver failure syndrome 1 9.7
47 alacrima, achalasia, and mental retardation syndrome 9.7
48 west syndrome 9.7
49 arthritis 9.7
50 liver disease 9.7

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to Reye Syndrome

Symptoms & Phenotypes for Reye Syndrome

UMLS symptoms related to Reye Syndrome:


back pain, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Reye Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 HMGCL HMGCR OAT OTC PC SCD
2 homeostasis/metabolism MP:0005376 9.81 HMGCL HMGCR OAT OTC ACADM SCD
3 liver/biliary system MP:0005370 9.5 HMGCR OTC ACADM SCD CES1 HADHA
4 mortality/aging MP:0010768 9.23 HMGCL HMGCR OAT OTC PC ACADM

Drugs & Therapeutics for Reye Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intracranial Hypertension and Optic Nerve Sheath Diameter Completed NCT01796015 Not Applicable

Search NIH Clinical Center for Reye Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: reye syndrome

Genetic Tests for Reye Syndrome

Anatomical Context for Reye Syndrome

MalaCards organs/tissues related to Reye Syndrome:

41
Liver, Brain, Skin, Bone, Pons, Thalamus, Kidney

Publications for Reye Syndrome

Articles related to Reye Syndrome:

(show top 50) (show all 224)
# Title Authors Year
1
Co-Ingestion of Aspirin and Acetaminophen Promoting Fulminant Liver Failure: A Critical Review of Reye Syndrome in the Current Perspective at the Dawn of the 21(st) Century. ( 28945927 )
2017
2
Impact of fatty acid oxidation disorders in child neurology: from Reye syndrome to Pandora's box. ( 25761966 )
2015
3
Hyponatremic seizures and Reye syndrome. ( 23829993 )
2013
4
Did the patient have Reye syndrome? ( 21980824 )
2011
5
Magnetic resonance imaging findings in Reye syndrome: case report and review of the literature. ( 21633106 )
2011
6
Acute encephalopathy of Bacillus cereus mimicking Reye syndrome. ( 19796886 )
2010
7
Reye syndrome and liver transplantation. ( 21428204 )
2010
8
Reye syndrome: a case report with review of literature. ( 18552890 )
2008
9
Reye syndrome and reye-like syndrome. ( 18725066 )
2008
10
Aspirin and Reye syndrome. ( 17523701 )
2007
11
Aspirin and Reye syndrome: a review of the evidence. ( 17523700 )
2007
12
The thalamus and midbrain in Reye syndrome. ( 16648004 )
2006
13
Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. ( 16254043 )
2006
14
A case of Reye syndrome with rotavirus infection accompanied with high cytokines. ( 16226809 )
2006
15
Aspirin, Reye syndrome, Kawasaki disease, and allergies; a reconsideration of the links. ( 15557065 )
2004
16
Reassessing Reye syndrome. ( 14662583 )
2003
17
Reye syndrome. ( 12865641 )
2003
18
[Reye syndrome and drug induced encephalopathy]. ( 15152490 )
2003
19
Rotavirus, hepatitis and Reye syndrome. ( 12354277 )
2002
20
A fatal case of Reye syndrome after varicella and ingestion of aspirin. ( 11436370 )
2001
21
Reye syndrome--insights on causation and prognosis. ( 11668090 )
2001
22
Rotavirus gastroenteritis possibly causing reye syndrome. ( 10852203 )
2000
23
Reye syndrome revisited: a descriptive term covering a group of heterogeneous disorders. ( 11014461 )
2000
24
A long-term follow-up of cognitive, emotional, and behavioural sequelae to Reye syndrome. ( 10479043 )
1999
25
Reye's syndrome and salicylate use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863. ( 9729163 )
1998
26
Single-photon emission CT and MR findings in KlA1ver-Bucy syndrome after Reye syndrome. ( 9090419 )
1997
27
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. ( 8840534 )
1996
28
Reye syndrome: an international perspective. ( 8882577 )
1995
29
Reye syndrome model in rats: protection against liver abnormalities by L-carnitine and acetyl-L-carnitine. ( 7473134 )
1995
30
Fructose-1,6-diphosphatase deficiency misdiagnosed as Reye syndrome. ( 8591687 )
1995
31
3-Methylglutaconic aciduria presenting as Reye syndrome in a Chinese boy. ( 8598651 )
1995
32
Medium-chain acyl-CoA dehydrogenase deficiency is not a cause of previously diagnosed Reye syndrome. ( 7474911 )
1995
33
[A case of clinical Reye syndrome with symmetrical abnormal signal areas in the pons and thalami by MRI]. ( 8280450 )
1994
34
Reye syndrome associated with subclinical varicella zoster virus and influenza A infection. ( 8388687 )
1993
35
Symmetrical thalamic lesions on CT in influenza A virus infection presenting with or without Reye syndrome. ( 7687829 )
1993
36
Medium-chain acylcoenzyme-A dehydrogenase deficiency. Not just another Reye syndrome. ( 8116590 )
1993
37
Reye syndrome. ( 1537363 )
1992
38
Kawasaki disease with Reye syndrome: report of one case. ( 1626454 )
1992
39
Liver histopathology in clinical Reye syndrome. ( 1892227 )
1991
40
From the Centers for Disease Control. Reye syndrome surveillance--United States, 1989. ( 1992203 )
1991
41
Neuropathologic findings in Reye syndrome. ( 2002200 )
1991
42
Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome. ( 1846348 )
1991
43
Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome. ( 1847937 )
1991
44
Reye syndrome surveillance, 1989--United States. ( 1889094 )
1991
45
Interrelationships of liver and brain with special reference to Reye syndrome. ( 1749212 )
1991
46
Reye syndrome surveillance--United States, 1989. ( 1899129 )
1991
47
Reye syndrome or side-effects of anti-emetics? ( 1655459 )
1991
48
A sibling-controlled study of intelligence and academic performance following Reye syndrome. ( 1936633 )
1991
49
Reye syndrome. ( 2386709 )
1990
50
Medium-chain acyl CoA dehydrogenase deficiency: electron microscopic differentiation from Reye syndrome. ( 2279505 )
1990

Variations for Reye Syndrome

Expression for Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for Reye Syndrome

Pathways related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 ACADM ASS1 CES1 HADHA HMGCL HMGCR
2
Show member pathways
12.49 ACADM HADHA HMGCL HMGCR SCD
3
Show member pathways
11.7 ACADM HADHA HMGCL
4
Show member pathways
11.68 ACADM ASS1 HADHA OTC PC
5
Show member pathways
11.51 ACADM HADHA SCD
6
Show member pathways
11.4 ACADM HADHA
7
Show member pathways
11.29 HADHA SCD
8
Show member pathways
11.28 ACADM HADHA
9
Show member pathways
11.13 HADHA HMGCL
10
Show member pathways
11.07 ACADM HADHA
11 11.06 ACADM ASS1 HMGCL OAT OTC PC
12 11.03 ACADM HADHA
13
Show member pathways
10.93 ASS1 OTC
14 10.84 PC SCD
15
Show member pathways
10.81 ASS1 OAT OTC
16 10.76 HMGCR SCD
17
Show member pathways
10.55 ASS1 PC
18
Show member pathways
10.4 ACADM HADHA

GO Terms for Reye Syndrome

Cellular components related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.5 ACADM ASS1 HADHA HMGCL OAT OTC
2 mitochondrial matrix GO:0005759 9.02 ACADM HMGCL OAT OTC PC

Biological processes related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.86 ACADM HADHA HMGCR SCD
2 response to drug GO:0042493 9.75 ASS1 HADHA OTC
3 fatty acid metabolic process GO:0006631 9.65 ACADM HADHA SCD
4 fatty acid beta-oxidation GO:0006635 9.57 ACADM HADHA
5 cholesterol biosynthetic process GO:0006695 9.55 CES1 HMGCR
6 response to starvation GO:0042594 9.54 ACADM HMGCL
7 liver development GO:0001889 9.54 ASS1 HMGCL OTC
8 protein tetramerization GO:0051262 9.52 HMGCL HMGCR
9 regulation of cholesterol biosynthetic process GO:0045540 9.51 HMGCR SCD
10 response to nutrient GO:0007584 9.5 ASS1 HMGCL HMGCR
11 response to zinc ion GO:0010043 9.49 ASS1 OTC
12 response to fatty acid GO:0070542 9.46 ASS1 HMGCL
13 urea cycle GO:0000050 9.43 ASS1 OTC
14 midgut development GO:0007494 9.4 ASS1 OTC
15 arginine biosynthetic process GO:0006526 9.26 ASS1 OTC
16 medium-chain fatty acid metabolic process GO:0051791 9.16 ACADM CES1
17 cellular amino acid biosynthetic process GO:0008652 9.13 ASS1 OAT OTC
18 lipid metabolic process GO:0006629 9.1 ACADM HADHA HMGCL HMGCR PC SCD

Molecular functions related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.46 ACADM HADHA HMGCR SCD
2 catalytic activity GO:0003824 9.43 HADHA HMGCL PC
3 amino acid binding GO:0016597 8.96 ASS1 OTC
4 fatty-acyl-CoA binding GO:0000062 8.62 HADHA HMGCL

Sources for Reye Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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