RS
MCID: RYS001
MIFTS: 49

Reye Syndrome (RS)

Categories: Bone diseases, Infectious diseases, Liver diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Reye Syndrome

MalaCards integrated aliases for Reye Syndrome:

Name: Reye Syndrome 12 53 59 55 43 44 15 17 72 33
Reye's Syndrome 12 75 53 54
Fatty Liver with Encephalopathy 53
Rs 53

Classifications:



External Ids:

Disease Ontology 12 DOID:14525
ICD9CM 35 331.81
MeSH 44 D012202
NCIt 50 C34983
SNOMED-CT 68 74351001
ICD10 33 G93.7
MESH via Orphanet 45 D012202
ICD10 via Orphanet 34 G93.7
UMLS via Orphanet 73 C0035400
Orphanet 59 ORPHA3096
UMLS 72 C0035400

Summaries for Reye Syndrome

NINDS : 54 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards based summary : Reye Syndrome, also known as reye's syndrome, is related to acyl-coa dehydrogenase, medium-chain, deficiency of and long-chain 3-hydroxyacyl-coa dehydrogenase deficiency, and has symptoms including seizures, tremor and back pain. An important gene associated with Reye Syndrome is ACADM (Acyl-CoA Dehydrogenase Medium Chain), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and testes, and related phenotypes are homeostasis/metabolism and growth/size/body region

Disease Ontology : 12 A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use.

MedlinePlus : 43 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include Nausea and vomiting Listlessness Personality change - such as irritability, combativeness or confusion Delirium Convulsions Loss of consciousness If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure. The cause of Reye syndrome is unknown. Studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 75 Reye syndrome is a rapidly progressive encephalopathy. Symptoms may include vomiting, personality... more...

Related Diseases for Reye Syndrome

Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 483)
# Related Disease Score Top Affiliating Genes
1 acyl-coa dehydrogenase, medium-chain, deficiency of 33.0 HADHA ACADM
2 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 32.5 HADHA ACADM
3 3-hydroxyacyl-coa dehydrogenase deficiency 32.1 OTC HADHA ACADM
4 acyl-coa dehydrogenase, very long-chain, deficiency of 32.1 HMGCL HADHA
5 carbonic anhydrase va deficiency, hyperammonemia due to 30.9 OTC ASS1
6 carbamoyl phosphate synthetase i deficiency, hyperammonemia due to 30.3 OTC ASS1
7 ornithine transcarbamylase deficiency, hyperammonemia due to 30.1 OTC ASS1
8 argininosuccinic aciduria 30.0 OTC ASS1
9 propionic acidemia 29.9 OTC HMGCL ASS1
10 organic acidemia 29.8 HMGCL ACADM
11 severe combined immunodeficiency with sensitivity to ionizing radiation 12.0
12 lymphoma, hodgkin, classic 11.6
13 3-hydroxy-3-methylglutaryl-coa lyase deficiency 11.6
14 3-methylcrotonyl-coa carboxylase deficiency 11.6
15 retinoschisis 1, x-linked, juvenile 11.6
16 chickenpox 11.5
17 myelodysplastic syndrome 11.5
18 richter's syndrome 11.5
19 raynaud disease 11.5
20 robinow syndrome 11.5
21 bilirubin metabolic disorder 11.4
22 acyl-coa dehydrogenase, short-chain, deficiency of 11.3
23 carnitine deficiency, systemic primary 11.3
24 carnitine palmitoyltransferase i deficiency 11.3
25 mitochondrial trifunctional protein deficiency 11.3
26 roberts syndrome 11.1
27 lymphoma, hodgkin, x-linked pseudoautosomal 11.1
28 encephalopathy 10.6
29 ocular motor apraxia 10.5
30 hypoglycemia 10.4
31 postpartum psychosis 10.3 OTC ASS1
32 low compliance bladder 10.3
33 citrullinemia, classic 10.3 OTC ASS1
34 urea cycle disorder 10.3 OTC ASS1
35 influenza 10.2
36 medium-chain acyl-coenzyme a dehydrogenase deficiency 10.2
37 acyl-coa dehydrogenase deficiency 10.2
38 bronchiolitis 10.2
39 argininemia 10.2 OTC ASS1
40 brain edema 10.2
41 fatty liver disease 10.2
42 orotic aciduria 10.2 OTC ASS1
43 lactic acidosis 10.1
44 tetanus 10.1
45 hepatic coma 10.1
46 gastroenteritis 10.1
47 kidney disease 10.1
48 encephalitis 10.1
49 phenylketonuria 10.1 OTC HADHA ACADM
50 attention deficit-hyperactivity disorder 10.1

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to Reye Syndrome

Symptoms & Phenotypes for Reye Syndrome

UMLS symptoms related to Reye Syndrome:


seizures, tremor, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to Reye Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ACADM ASS1 CES1 HADHA HMGCL HMGCR
2 growth/size/body region MP:0005378 9.8 ASS1 HADHA HMGCL HMGCR OAT OTC
3 liver/biliary system MP:0005370 9.5 ACADM CES1 HADHA HMGCL HMGCR OTC
4 mortality/aging MP:0010768 9.23 ACADM ASS1 HADHA HMGCL HMGCR OAT

Drugs & Therapeutics for Reye Syndrome

Drugs for Reye Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines
2 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intracranial Hypertension Detection Using Optic Nerve Sheath Diameter Measurement in Children Completed NCT01796015
2 Randomized Evaluation of Live Attenuated vs.Trivalent Inactivated Influenza Vaccines in Schools (RELATIVES)Pilot Study Completed NCT01995851

Search NIH Clinical Center for Reye Syndrome

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Perphenazine

Cochrane evidence based reviews: reye syndrome

Genetic Tests for Reye Syndrome

Anatomical Context for Reye Syndrome

MalaCards organs/tissues related to Reye Syndrome:

41
Liver, Brain, Testes, Bone, Kidney, Heart, Skeletal Muscle

Publications for Reye Syndrome

Articles related to Reye Syndrome:

(show top 50) (show all 1670)
# Title Authors PMID Year
1
Co-ingestion of aspirin and acetaminophen promoting fulminant liver failure: A critical review of Reye syndrome in the current perspective at the dawn of the 21st century. 38 17
28945927 2018
2
Carnitine palmitoyltransferase 1A deficiency: abnormal muscle biopsy findings in a child presenting with Reye's syndrome. 38 17
28466427 2017
3
Inborn Errors of Metabolism That Cause Sudden Infant Death: A Systematic Review with Implications for Population Neonatal Screening Programmes. 38 17
26907928 2016
4
Evidence that antioxidants prevent the inhibition of Na+,K(+)-ATPase activity induced by octanoic acid in rat cerebral cortex in vitro. 9 38
12892042 2003
5
Successful use of alternate waste nitrogen agents and hemodialysis in a patient with hyperammonemic coma after heart-lung transplantation. 9 38
10199339 1999
6
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. 9 38
8840534 1996
7
[Hydroxy-methyl-glutaryl-coenzyme A lyase deficiency manifesting as Reye's syndrome in a 3-year-old girl]. 9 38
7777393 1993
8
Displacement of hepatic ornithine carbamoyltransferase from mitochondria to cytosol in Reye's syndrome. 9 38
1782015 1991
9
Prevalence of K329E mutation in medium-chain acyl-CoA dehydrogenase gene determined from Guthrie cards. 9 38
1678810 1991
10
[Hyperlysinemia and hyperammonemia]. 9 38
1904697 1991
11
Hepatic polyamine metabolism in children with Reye's syndrome. 9 38
1823865 1991
12
Medium-chain acyl CoA dehydrogenase deficiency: electron microscopic differentiation from Reye syndrome. 9 38
2279505 1990
13
[Medium-chain acyl-CoA dehydrogenase defect. Acute cerebral episodes and nonketotic hypoglycemia in children]. 9 38
2387217 1990
14
A case of ornithine transcarbamylase deficiency with acute and late onset simulating Reye's syndrome in an adult male. 9 38
2255172 1990
15
First Case Report of Primary Carnitine Deficiency Manifested as Intellectual Disability and Autism Spectrum Disorder. 38
31200524 2019
16
Presence of unreported carcinogens, Aflatoxins and their hydroxylated metabolites, in industrialized Oaxaca cheese from Mexico City. 38
30468840 2019
17
Detection and monitoring of in vitro formation of salicylic acid from aspirin using fluorescence spectroscopic technique and DFT calculations. 38
30445361 2018
18
[Reye syndrome and sudden death symptoms after oral administration of nimesulide due to upper respiratory tract infection in a boy]. 38
30477628 2018
19
Lipid Storage Myopathy with Ketonuria: A Case of Fatty Acid Oxidation-Related Myopathy and Encephalopathy due to Multiple Acyl-CoA Dehydrogenase Deficiency. 38
30271477 2018
20
Hemorrhagic Stroke and Cerebral Venous Thrombosis: Rare Neurological Sequelae of Chickenpox Infection. 38
30258269 2018
21
Acute Kidney Failure as a Single Complication of Varicella Virus Infection in an Adult Patient. 38
30197901 2018
22
A Case of Reye Syndrome Caused by Influenza A Virus. 38
30559633 2018
23
Presumed acute fatty liver of pregnancy following influenza A hepatitis. 38
29225680 2017
24
REYE (RAY'S) SYNDROME: A PROBLEM EVERYONE SHOULD REMEMBER. 38
29227269 2017
25
[ACTION OF L-CARNITINE, CORVITIN AND THEIR COMBINATION ON FUNCTIONAL STATE OF LIVER IN EXPERIMENTAL MODEL OF REYE SYNDROME IN RATS]. 38
28452736 2017
26
Aspirin increases mitochondrial fatty acid oxidation. 38
27856258 2017
27
Management and long-term evolution of a patient with 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency. 38
28257639 2017
28
The Measurement of Ammonia in Human Breath and its Potential in Clinical Diagnostics. 38
26907707 2016
29
[Side Effects of Acetaminophen and their Management]. 38
30358301 2016
30
Clinical aspects of urea cycle dysfunction and altered brain energy metabolism on modulation of glutamate receptors and transporters in acute and chronic hyperammonemia. 38
27261594 2016
31
Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules. 38
26826406 2016
32
The Use of p-Aminobenzoic Acid as a Probe Substance for the Targeted Profiling of Glycine Conjugation. 38
26484797 2016
33
Acetylsalicylic acid as a potential pediatric health hazard: legislative aspects concerning accidental intoxications in the European Union. 38
27418941 2016
34
Impact of fatty acid oxidation disorders in child neurology: from Reye syndrome to Pandora's box. 38
25761966 2015
35
Aspirin-Induced Acute Liver Injury. 38
26157904 2014
36
Resveratrol protects against experimental induced Reye's syndrome by prohibition of oxidative stress and restoration of complex I activity. 38
25162205 2014
37
Update on pediatric neurocritical care. 38
24698020 2014
38
Cerebellar mutism caused by primary varicella infection in an immunocompetent child. 38
23446802 2014
39
Pediatric parechovirus infections. 38
24690382 2014
40
The history of external ventricular drainage. 38
23889138 2014
41
Nonsteroidal anti-inflammatory drugs exposure and the central nervous system. 38
24365321 2014
42
[Aspirin and its danger: Reye syndrome in young adult]. 38
24161294 2013
43
Clinical and biological features at diagnosis in mitochondrial fatty acid beta-oxidation defects: a French pediatric study of 187 patients. 38
23053472 2013
44
Growth and development of a new subspecialty: pediatric hepatology. 38
23788321 2013
45
Bismuth salicylate for diarrhea in children. 38
23946025 2013
46
Hyponatremic seizures and Reye syndrome. 38
23829993 2013
47
Management of a child with vomiting. 38
23340985 2013
48
Use of common migraine treatments in breast-feeding women: a summary of recommendations. 38
23465038 2013
49
Case of Reye's syndrome accompanied by hemolytic anemia and cardiac injury after cytomegalovirus infection. 38
23172230 2013
50
Linking drugs to obscure illnesses: lessons from pure red cell aplasia, nephrogenic systemic fibrosis, and Reye's syndrome. a report from the Southern Network on Adverse Reactions (SONAR). 38
22692632 2012

Variations for Reye Syndrome

Expression for Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for Reye Syndrome

Pathways related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 SCD PC OTC OAT HMGCR HMGCL
2
Show member pathways
12.49 SCD HMGCR HMGCL HADHA ACADM
3
Show member pathways
11.68 HMGCL HADHA ACADM
4
Show member pathways
11.68 PC OTC HADHA ASS1 ACADM
5 11.43 SCD HMGCR
6
Show member pathways
11.38 HADHA ACADM
7
Show member pathways
11.27 HADHA ACADM
8
Show member pathways
11.12 HMGCL HADHA
9
Show member pathways
11.08 HADHA ACADM
10 11.06 PC OTC OAT HMGCL ASS1 ACADM
11 11.04 HADHA ACADM
12
Show member pathways
10.91 OTC ASS1
13 10.82 SCD PC
14
Show member pathways
10.81 OTC OAT ASS1
15 10.74 SCD HMGCR
16
Show member pathways
10.52 PC ASS1
17
Show member pathways
10.37 HADHA ACADM

GO Terms for Reye Syndrome

Cellular components related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.5 PC OTC OAT HMGCL HADHA ASS1
2 mitochondrial matrix GO:0005759 9.02 PC OTC OAT HMGCL ACADM

Biological processes related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.86 SCD HMGCR HADHA ACADM
2 response to drug GO:0042493 9.75 OTC HADHA ASS1
3 fatty acid metabolic process GO:0006631 9.65 SCD HADHA ACADM
4 response to insulin GO:0032868 9.58 OTC HADHA
5 liver development GO:0001889 9.58 OTC HMGCL ASS1
6 fatty acid beta-oxidation GO:0006635 9.57 HADHA ACADM
7 cholesterol biosynthetic process GO:0006695 9.55 HMGCR CES1
8 response to starvation GO:0042594 9.54 HMGCL ACADM
9 response to nutrient GO:0007584 9.54 HMGCR HMGCL ASS1
10 protein tetramerization GO:0051262 9.52 HMGCR HMGCL
11 regulation of cholesterol biosynthetic process GO:0045540 9.51 SCD HMGCR
12 response to zinc ion GO:0010043 9.49 OTC ASS1
13 urea cycle GO:0000050 9.46 OTC ASS1
14 midgut development GO:0007494 9.43 OTC ASS1
15 cellular amino acid biosynthetic process GO:0008652 9.33 OTC OAT ASS1
16 arginine biosynthetic process GO:0006526 9.32 OTC ASS1
17 medium-chain fatty acid metabolic process GO:0051791 9.26 CES1 ACADM
18 response to fatty acid GO:0070542 9.13 SCD HMGCL ASS1
19 lipid metabolic process GO:0006629 9.1 SCD PC HMGCR HMGCL HADHA ACADM

Molecular functions related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.46 SCD HMGCR HADHA ACADM
2 catalytic activity GO:0003824 9.43 PC HMGCL HADHA
3 amino acid binding GO:0016597 8.96 OTC ASS1
4 fatty-acyl-CoA binding GO:0000062 8.62 HMGCL HADHA

Sources for Reye Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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