MCID: RHS001
MIFTS: 29

Rh Isoimmunization

Categories: Blood diseases
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Aliases & Classifications for Rh Isoimmunization

MalaCards integrated aliases for Rh Isoimmunization:

Name: Rh Isoimmunization 11 53 43 14 16 71
Rh Incompatibility Affecting Management of Mother 11

Classifications:



External Ids:

Disease Ontology 11 DOID:4175
MeSH 43 D012203
NCIt 49 C113150
SNOMED-CT 68 199580004
UMLS 71 C0035404

Summaries for Rh Isoimmunization

MalaCards based summary: Rh Isoimmunization, also known as rh incompatibility affecting management of mother, is related to fetal erythroblastosis and neonatal jaundice. An important gene associated with Rh Isoimmunization is EPO (Erythropoietin), and among its related pathways/superpathways is Blood group systems biosynthesis. Affiliated tissues include placenta, fetal lung and pancreatic islet, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Rh Isoimmunization

Diseases related to Rh Isoimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 fetal erythroblastosis 30.7 RHD RHCE
2 neonatal jaundice 30.1 RHD G6PD
3 neonatal anemia 30.0 RHD RHCE EPO
4 deficiency anemia 30.0 RHD RHCE G6PD EPO
5 ectopic pregnancy 29.9 CSH2 CSH1
6 hereditary spherocytosis 29.9 RHD G6PD EPO
7 bilirubin metabolic disorder 29.6 RHD RHCE G6PD EPO
8 blood group incompatibility 28.6 RHD RHCE G6PD FYB1 EPO DHCR24
9 hydrops fetalis, nonimmune 10.3
10 splenic sequestration 10.1 RHCE EPO
11 hemolytic disease of fetus and newborn, rh-induced 10.1 RHD RHCE
12 patau syndrome 10.1 RHD RHCE
13 beta-thalassemia major 10.1 RHCE EPO
14 sickle cell disease 10.1 G6PD EPO
15 iron metabolism disease 10.0 G6PD EPO
16 diabetes insipidus, nephrogenic, 2, autosomal 10.0
17 iron overload 10.0
18 pyelonephritis 10.0
19 hemosiderosis 10.0
20 eclampsia 10.0
21 syphilis 10.0
22 placental abruption 10.0
23 hemolytic disease due to fetomaternal alloimmunization 10.0
24 microcytic anemia 10.0 G6PD EPO
25 congenital hemolytic anemia 10.0 G6PD EPO
26 hemoglobinuria 10.0 G6PD EPO
27 iron deficiency anemia 10.0 G6PD EPO
28 testicular trophoblastic tumor 10.0 CSH2 CSH1
29 non-gestational ovarian choriocarcinoma 9.9 CSH2 CSH1
30 gestational ovarian choriocarcinoma 9.9 CSH2 CSH1
31 choriocarcinoma of ovary 9.9 CSH2 CSH1
32 corpus luteum cyst 9.9 CSH2 CSH1
33 non-gestational choriocarcinoma 9.9 CSH2 CSH1
34 gestational choriocarcinoma 9.9 CSH2 CSH1
35 epithelioid trophoblastic tumor 9.9 CSH2 CSH1
36 rete ovarii adenoma 9.9 CSH2 CSH1
37 rete ovarii benign neoplasm 9.9 CSH2 CSH1
38 mixed germ cell cancer 9.9 CSH2 CSH1
39 supine hypotensive syndrome 9.9 CSH2 CSH1
40 placental site trophoblastic tumor 9.9 CSH2 CSH1
41 placental choriocarcinoma 9.9 CSH2 CSH1
42 kernicterus 9.9 RHD RHCE G6PD
43 hereditary elliptocytosis 9.9 RHD RHCE G6PD
44 persistent fetal circulation syndrome 9.9 CSH2 CSH1
45 trophoblastic neoplasm 9.9 CSH2 CSH1
46 beta-thalassemia 9.9 RHD G6PD EPO
47 plasmodium vivax malaria 9.8 G6PD FYB1
48 toxoplasmosis 9.8 RHD G6PD
49 gestational trophoblastic neoplasm 9.8 CSH2 CSH1
50 anemia, autoimmune hemolytic 9.7 RHD RHCE G6PD EPO

Graphical network of the top 20 diseases related to Rh Isoimmunization:



Diseases related to Rh Isoimmunization

Symptoms & Phenotypes for Rh Isoimmunization

MGI Mouse Phenotypes related to Rh Isoimmunization:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.56 CSH1 CSH2 DHCR24 EPO FYB1 G6PD
2 hematopoietic system MP:0005397 9.17 CSH1 CSH2 EPO FYB1 G6PD RHCE

Drugs & Therapeutics for Rh Isoimmunization

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Minimally Invasive Management of Rh Alloimmunization: Can Amniotic Fluid DeltaOD450 Measurements Be Replaced by Doppler Studies? Completed NCT00295516 Phase 3

Search NIH Clinical Center for Rh Isoimmunization

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Rho(D) Immune Globulin, human

Cochrane evidence based reviews: rh isoimmunization

Genetic Tests for Rh Isoimmunization

Anatomical Context for Rh Isoimmunization

Organs/tissues related to Rh Isoimmunization:

MalaCards : Placenta, Fetal Lung, Pancreatic Islet, Heart, Fetal Thyroid, Bone Marrow, Fetal Brain

Publications for Rh Isoimmunization

Articles related to Rh Isoimmunization:

(show top 50) (show all 376)
# Title Authors PMID Year
1
Management of late anemia in Rhesus hemolytic disease: use of recombinant human erythropoietin (a pilot study). 53 62
8726237 1996
2
Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis. 53 62
8355933 1993
3
Fetal Brain Injury in Rhesus Isoimmunization Fetus. 62
35103225 2022
4
Fetal-maternal incompatibility in the Rh system. Rh isoimmunization associated with hereditary spherocytosis: case presentation and review of the literature. 62
36074689 2022
5
Prevalence of rhesus D-negative blood type and the challenges of rhesus D immunoprophylaxis among obstetric population in Ethiopia: a systematic review and meta-analysis. 62
33531050 2021
6
An Unusual Case of Hemolytic Disease of Newborn Due to ABO and Rh Isoimmunization. 62
33489535 2020
7
Severe neonatal hyperbilirubinemia in the southeast region of Turkey 62
31731336 2020
8
Evaluation of Rh-Hemolytic Disease in Neonates and Management with Early Intensive Phototherapy in the Neonatal Intensive Care Unit. 62
31199484 2020
9
Rhesus Isoimmunization: Late-onset Hemolytic Disease of the Newborn Without Jaundice. 62
32042531 2020
10
Hyperbilirubinemia in Preterm Infants Admitted to Neonatal Intensive Care Units in Ethiopia. 62
33457466 2020
11
Rh-incompatible hemolytic disease of the newborn in Hefei. 62
31667170 2019
12
A Multicenter, Randomized, Open-Label Trial Comparing the Efficacy and Safety of Monoclonal Anti-Rh (D) Immunoglobulin with Polyclonal Anti-Rh (D) Immunoglobulin for the Prevention of Maternal Rh-Isoimmunization. 62
31598044 2019
13
Hemolytic anemia caused by non-D minor blood incompatibilities in a newborn. 62
31692740 2019
14
An early, customized low-glycemic-index diet prevents adverse pregnancy outcomes in overweight/obese women. 62
29083138 2018
15
Discordant intrauterine transfusion in dichorionic twin pregnancy with Rh isoimmunization. 62
29153312 2017
16
Maternal-fetal Rhesus (Rh) factor incompatibility in Arar, northern Saudi Arabia. 62
29560141 2017
17
Rh isoimmunized pregnancy managed noninvasively: A report of two cases. 62
28251113 2017
18
[Neonatal Morbidity in Term Newborns Born by Elective Cesarean Section]. 62
26667863 2015
19
A Doppler velocimetry evaluation of intestinal blood flow characteristics in neonates receiving intravenous immunoglobulin therapy: a prospective observational study. 62
25598445 2015
20
Antenatal Maternal Serum IAT Titer and Fetal Outcome in Rh Isoimmunized Pregnancies. 62
25548460 2015
21
[THE FETAL MIDDLE CEREBRAL ARTERY PEAK SYSTOLIC VELOCITY AS A PEDICTOR OF FETAL ANEMIA IN RH-ALLOIMMUNIZED PREGNANCY]. 62
26410952 2015
22
Management of hypersensitivity reactions to anti-D immunoglobulin preparations. 62
25066207 2014
23
Hearing and neurological impairment in children with history of exchange transfusion for neonatal hyperbilirubinemia. 62
24678325 2014
24
Congenital portosystemic venous shunt in a preterm Rh-isoimmunized infant. 62
23389350 2013
25
Evolving trends: hyperbilirubinemia among newborns delivered to rh negative mothers in southern India. 62
24392385 2013
26
[Cavernous transformation of portal vein]. 62
23211206 2012
27
Comparison between two treatment protocols with recombinant human erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-isoimmunization. 62
23173411 2012
28
Refractory cholestasis presenting as cholangiolitis in an Rh (E)-incompatible neonate. 62
21040076 2012
29
Desferrioxamine treatment of iron overload secondary to RH isoimmunization and intrauterine transfusion in a newborn infant. 62
21735053 2011
30
The effectiveness of recombinant human erythropoietin (EPO) treatment in a neonate with hyporegenerative anemia following Rh isoimmunization in spite of normal serum Epo level. 62
21875319 2011
31
[Analysis and perinatal outcome after intravascular transfusion]. 62
21966826 2011
32
[An analysis of RHD zygosity of Rh(D)-positive Chinese Han population]. 62
21287505 2011
33
[Erythropoietin treatment for late anaemia after haemolytic disease of the newborn]. 62
20970396 2010
34
Rh isoimmunization in Sub-Saharan Africa indicates need for universal access to anti-RhD immunoglobulin and effective management of D-negative pregnancies. 62
21270966 2010
35
Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates. 62
20628321 2010
36
Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization. 62
20216236 2010
37
Massive myocardial infarction in a full-term newborn: a case report. 62
20634906 2010
38
Incidence, causes and pregnancy outcomes of hydrops fetalis at Srinagarind Hospital, 1996-2005: a 10-year review. 62
19459517 2009
39
Growth-promoting effect of Rh(D) antibody on human pancreatic islet cells. 62
18544617 2008
40
Successful pregnancy in a patient with severe combined immunodeficiency syndrome treated with bone marrow transplantation. 62
18669756 2008
41
Spontaneous ovarian hyperstimulation in a naturally conceived pregnancy with uncontrolled hypothyroidism. 62
18238999 2008
42
Intraperitoneal transfusion in severe, early-onset Rh isoimmunization. 62
17906023 2007
43
Severe hemolytic disease of the newborn due to anti-Cw. 62
16260563 2005
44
[Persistent neonatal hyperbilirubinemia resulting from Gilbert's syndrome in association with RhD hemolytic disease]. 62
16247547 2005
45
A randomized, triple-blind, placebo-controlled trial of prophylactic oral phenobarbital to reduce the need for phototherapy in G6PD-deficient neonates. 62
15716985 2005
46
Prevention and management of RhD isoimmunization. 62
15519425 2004
47
Intrauterine fetal transfusion. 62
15711685 2004
48
Bilateral mesial temporal sclerosis and kernicterus. 62
15091133 2004
49
Fetal Doppler velocimetry. 62
15062454 2004
50
Noninvasive management of Rh partial null (D--) to supplement traditional management of Rh isoimmunization. 62
14607036 2003

Variations for Rh Isoimmunization

Expression for Rh Isoimmunization

Search GEO for disease gene expression data for Rh Isoimmunization.

Pathways for Rh Isoimmunization

Pathways related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 RHD RHCE

GO Terms for Rh Isoimmunization

Biological processes related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol biosynthetic process GO:0006695 9.76 G6PD DHCR24
2 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.73 CSH2 CSH1
3 animal organ development GO:0048513 9.71 CSH2 CSH1
4 erythrocyte maturation GO:0043249 9.67 G6PD EPO
5 growth hormone receptor signaling pathway GO:0060396 9.62 CSH2 CSH1
6 positive regulation of growth GO:0045927 9.56 CSH2 CSH1
7 ammonium transmembrane transport GO:0072488 9.46 RHD RHCE
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 EPO CSH2 CSH1
9 ammonium homeostasis GO:0097272 8.92 RHD RHCE

Molecular functions related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.63 EPO CSH2 CSH1
2 ammonium transmembrane transporter activity GO:0008519 9.26 RHD RHCE
3 growth hormone receptor binding GO:0005131 8.92 CSH2 CSH1

Sources for Rh Isoimmunization

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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