MCID: RHS001
MIFTS: 30

Rh Isoimmunization

Categories: Blood diseases

Aliases & Classifications for Rh Isoimmunization

MalaCards integrated aliases for Rh Isoimmunization:

Name: Rh Isoimmunization 12 55 44 15 73
Rh Incompatibility Affecting Management of Mother 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4175
MeSH 44 D012203
NCIt 50 C113150
SNOMED-CT 68 44795003
UMLS 73 C0035404

Summaries for Rh Isoimmunization

MalaCards based summary : Rh Isoimmunization, also known as rh incompatibility affecting management of mother, is related to retinohepatoendocrinologic syndrome and pancreatic acinar cell adenocarcinoma. An important gene associated with Rh Isoimmunization is EPO (Erythropoietin). Affiliated tissues include placenta, heart and ovary.

Related Diseases for Rh Isoimmunization

Diseases related to Rh Isoimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 retinohepatoendocrinologic syndrome 10.3 RHCE RHD
2 pancreatic acinar cell adenocarcinoma 10.2 AFP BCL10
3 orofaciodigital syndrome viii 10.2 AFP BCL10
4 blood group incompatibility 10.2 CSH1 RHCE RHD
5 tuberculous epididymitis 10.2 AFP POMC
6 central nervous system germ cell tumor 10.2 AFP POMC
7 sheehan syndrome 10.2 EPO POMC
8 calciphylaxis 10.2 ALB EPO
9 male reproductive organ benign neoplasm 10.2 AFP POMC
10 testicular trophoblastic tumor 10.2 CSH1 CSH2
11 hepatoid adenocarcinoma 10.2 AFP ALB
12 choriocarcinoma of ovary 10.1 CSH1 CSH2
13 kernicterus 10.1 ALB RHCE
14 pyuria 10.1 ALB NUMA1
15 glossopharyngeal neuralgia 10.1 NUMA1 POMC
16 splenic disease 10.1 ALB EPO
17 noma 10.1 ALB POMC
18 anemia, autoimmune hemolytic 10.1 RHCE RHD
19 chorioangioma 10.1 AFP OXT
20 esophageal varix 10.1 AFP ALB
21 endodermal sinus tumor 10.1 AFP ALB
22 pure red-cell aplasia 10.1 ALB EPO
23 euthyroid sick syndrome 10.1 ALB POMC
24 postmenopausal atrophic vaginitis 10.1 OXT POMC
25 gastric lymphoma 10.1 ALB BCL10
26 thrombosis 10.1
27 pyelonephritis 10.1
28 hemosiderosis 10.1
29 eclampsia 10.1
30 choriocarcinoma of the testis 10.1 AFP CSH1 CSH2
31 hypersplenism 10.1 ALB EPO
32 germ cell and embryonal cancer 10.1 AFP CSH1 CSH2
33 thyroid crisis 10.1 ALB POMC
34 syndrome of inappropriate antidiuretic hormone 10.1 ALB POMC
35 dicrocoeliasis 10.0 ALB EPGN
36 trichostrongyloidiasis 10.0 ALB EPGN
37 urinary system disease 10.0 ALB EPO POMC
38 gastrointestinal system cancer 10.0 AFP ALB MSH6
39 non-gestational choriocarcinoma 10.0 CSH1 CSH2 MSH6
40 pancreas disease 10.0 ALB PNLIP POMC
41 gestational trophoblastic neoplasm 10.0 CSH1 CSH2 OXT
42 hemangioma of intra-abdominal structure 10.0 AFP OXT
43 chronic salpingitis 9.9 CSH1 CSH2
44 fetal erythroblastosis 9.9 ALB EPO POMC RHCE RHD
45 female reproductive system disease 9.8 CSH1 CSH2 MSH6 OXT
46 placenta disease 9.8 AFP CSH1 CSH2 OXT PNLIP
47 uterine anomalies 9.7 AFP CSH1 CSH2 MSH6 OXT

Graphical network of the top 20 diseases related to Rh Isoimmunization:



Diseases related to Rh Isoimmunization

Symptoms & Phenotypes for Rh Isoimmunization

Drugs & Therapeutics for Rh Isoimmunization

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
2 Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion Recruiting NCT03169907 Not Applicable

Search NIH Clinical Center for Rh Isoimmunization

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: rh isoimmunization

Genetic Tests for Rh Isoimmunization

Anatomical Context for Rh Isoimmunization

MalaCards organs/tissues related to Rh Isoimmunization:

41
Placenta, Heart, Ovary, Pancreas, Thyroid, Testis

Publications for Rh Isoimmunization

Articles related to Rh Isoimmunization:

(show top 50) (show all 94)
# Title Authors Year
1
Discordant intrauterine transfusion in dichorionic twin pregnancy with Rh isoimmunization. ( 29153312 )
2017
2
Comparison between two treatment protocols with recombinant human erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-isoimmunization. ( 23173411 )
2012
3
Desferrioxamine treatment of iron overload secondary to RH isoimmunization and intrauterine transfusion in a newborn infant. ( 21735053 )
2011
4
The effectiveness of recombinant human erythropoietin (EPO) treatment in a neonate with hyporegenerative anemia following Rh isoimmunization in spite of normal serum Epo level. ( 21875319 )
2011
5
Rh isoimmunization in Sub-Saharan Africa indicates need for universal access to anti-RhD immunoglobulin and effective management of D-negative pregnancies. ( 21270966 )
2010
6
Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates. ( 20628321 )
2010
7
Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization. ( 20216236 )
2010
8
Intraperitoneal transfusion in severe, early-onset Rh isoimmunization. ( 17906023 )
2007
9
Noninvasive management of Rh partial null (D--) to supplement traditional management of Rh isoimmunization. ( 14607036 )
2003
10
Ontogeny of the fetal immune system: study on pregnancies with Rh-isoimmunization and nonimmune fetal hydrops. ( 9884359 )
1999
11
Prevention of Rh isoimmunization after spontaneous, massive fetomaternal hemorrhage. ( 8790318 )
1996
12
Rho (D) immune globulin i.v. for prevention of Rh isoimmunization and for treatment of ITP. ( 8544794 )
1996
13
Rh isoimmunization complicating a triplet gestation. A case report. ( 1906542 )
1991
14
Fetal heart rate responses to anemia in Rh isoimmunization. ( 2117061 )
1990
15
A case of Rh isoimmunization: should threatened first-trimester abortion be an indication for Rh immune globulin prophylaxis? ( 2115737 )
1990
16
Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization. ( 2119561 )
1990
17
Acute Rh isoimmunization following abdominal trauma associated with late abruption placenta. ( 2517184 )
1989
18
Intrauterine transfusion via umbilical vein in severe Rh isoimmunization. ( 2499936 )
1989
19
Severe Rh isoimmunization--current methods of in utero diagnosis and treatment. ( 3132854 )
1988
20
Intravascular fetal blood transfusion under ultrasonic guidance in a case of severe Rh isoimmunization. ( 3150641 )
1988
21
Prevention of Rh isoimmunization and treatment of the compromised fetus. ( 3146812 )
1988
22
Umbilical cord hematoma secondary to in utero intravascular transfusion for Rh isoimmunization. ( 3142213 )
1987
23
Fetal blood velocities in Rh isoimmunization: relationship to gestational age and to fetal hematocrit. ( 2942811 )
1986
24
Compliance with postpartum Rh isoimmunization prophylaxis in Alberta. ( 2996738 )
1985
25
Circulating placental proteins in pregnancies complicated by RH isoimmunization. ( 6429588 )
1984
26
Rh isoimmunization following abdominal trauma: a case report. ( 6430091 )
1984
27
Clinical experience with the prevention of Rh-isoimmunization: a historical comparative analysis. ( 6202159 )
1984
28
Histopathological study of placenta in Rh isoimmunization. ( 6418646 )
1983
29
Rh isoimmunization related to amniocentesis. ( 6419606 )
1983
30
Pathophysiology of Rh isoimmunization. ( 6809383 )
1982
31
Rh isoimmunization following genetic amniocentesis. ( 6815628 )
1982
32
Plasmapheresis as an adjunct to management of Rh isoimmunization. ( 7192839 )
1981
33
Rh isoimmunization: a 24 year experience at Duke University Medical Center. ( 6791500 )
1981
34
RH isoimmunization prevention program in a community hospital. ( 106231 )
1979
35
Ultrasonographic diagnosis of intervillous thrombosis related to Rh isoimmunization. ( 119677 )
1979
36
RH isoimmunization. ( 106230 )
1979
37
The management of Rh-Isoimmunization. ( 98742 )
1978
38
Promethazine hydrochloride: use in patients with Rh isoimmunization. ( 637081 )
1978
39
Suppression of Rh isoimmunization. A review. ( 101918 )
1978
40
Rh isoimmunization during pregnancy: antenatal prophylaxis. ( 77714 )
1978
41
Antenatal prophylaxis of Rh isoimmunization: 28-weeks'-gestation service program. ( 77715 )
1978
42
Rh isoimmunization, Manitoba, 1963-75. ( 402178 )
1977
43
Clinical observation of the prevention of RH isoimmunization with immunoglobulin anti-D. ( 4219865 )
1974
44
The clinical value of amniotic fluid analysis in pregnancies complicated by Rh-isoimmunization or hepatosis. ( 4631936 )
1973
45
Oestriol conjugates in amniotic fluid. Qualitative and quantitative aspects, including preliminary studies in Rh isoimmunization. ( 4353745 )
1973
46
Sex ratio in Rh incompatibility and Rh isoimmunization. ( 4125603 )
1973
47
Plama estradiol, estriol, and progesterone in human pregnancy. II. Clinical applications in Rh-isoimmunization disease. ( 4628989 )
1972
48
Ten-year experience with high titer anti-D plasma for the prevention of Rh isoimmunization. ( 4628388 )
1972
49
The detection of anti-Rh O antibody as part of the programme in the prevention of Rh isoimmunization in Rh-negative mothers in Australia. ( 4112704 )
1972
50
Rh isoimmunization in ruptured pregnancy. ( 5083898 )
1972

Variations for Rh Isoimmunization

Expression for Rh Isoimmunization

Search GEO for disease gene expression data for Rh Isoimmunization.

Pathways for Rh Isoimmunization

GO Terms for Rh Isoimmunization

Cellular components related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 AFP ALB CSH1 CSH2 EPGN EPO
2 extracellular space GO:0005615 9.32 AFP ALB CSH1 CSH2 EPGN EPO

Biological processes related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 9.48 CSH1 CSH2
2 response to electrical stimulus GO:0051602 9.46 EPO OXT
3 response to food GO:0032094 9.43 BCL10 OXT
4 animal organ development GO:0048513 9.4 CSH1 CSH2
5 growth hormone receptor signaling pathway GO:0060396 9.37 CSH1 CSH2
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 CSH1 CSH2 EPO
7 positive regulation of growth GO:0045927 9.32 CSH1 CSH2
8 ammonium transmembrane transport GO:0072488 9.26 RHCE RHD
9 regulation of signaling receptor activity GO:0010469 9.02 CSH1 CSH2 EPO OXT POMC
10 ammonium transport GO:0015696 8.96 RHCE RHD

Molecular functions related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.43 CSH1 CSH2 EPGN
2 growth hormone receptor binding GO:0005131 9.16 CSH1 CSH2
3 hormone activity GO:0005179 9.02 CSH1 CSH2 EPO OXT POMC
4 ammonium transmembrane transporter activity GO:0008519 8.96 RHCE RHD

Sources for Rh Isoimmunization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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