MCID: RHS001
MIFTS: 28

Rh Isoimmunization

Categories: Blood diseases

Aliases & Classifications for Rh Isoimmunization

MalaCards integrated aliases for Rh Isoimmunization:

Name: Rh Isoimmunization 12 54 44 15 17 70
Rh Incompatibility Affecting Management of Mother 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4175
MeSH 44 D012203
NCIt 50 C113150
SNOMED-CT 67 199580004
UMLS 70 C0035404

Summaries for Rh Isoimmunization

MalaCards based summary : Rh Isoimmunization, also known as rh incompatibility affecting management of mother, is related to fetal erythroblastosis and neonatal anemia. An important gene associated with Rh Isoimmunization is EPO (Erythropoietin), and among its related pathways/superpathways is JAK-STAT signaling pathway. Affiliated tissues include placenta, thyroid and fetal lung, and related phenotype is Increased shRNA abundance.

Related Diseases for Rh Isoimmunization

Diseases related to Rh Isoimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 fetal erythroblastosis 30.5 RHD RHCE
2 neonatal anemia 30.1 RHD RHCE EPO
3 bilirubin metabolic disorder 29.1 RHD RHCE G6PD EPO AFP
4 hemolytic disease due to fetomaternal alloimmunization 10.4
5 deficiency anemia 10.3
6 splenic sequestration 10.2 RHCE EPO
7 lumbosacral lipoma 10.2 G6PD EPO
8 hemosiderosis 10.2
9 glutamate-cysteine ligase deficiency 10.2 RHD RHCE
10 rh deficiency syndrome 10.1 RHD RHCE
11 primary thrombocytopenia 10.1 RHD RHCE
12 anemia, autoimmune hemolytic 10.1 RHCE G6PD
13 iron metabolism disease 10.1 G6PD EPO
14 congenital dyserythropoietic anemia 10.1 RHD EPO
15 microcytic anemia 10.0 G6PD EPO
16 hemoglobinuria 10.0 G6PD EPO
17 hydrops fetalis, nonimmune 10.0
18 lymphatic malformation 7 10.0
19 ectopic pregnancy 10.0
20 pyelonephritis 10.0
21 neutropenia 10.0
22 eclampsia 10.0
23 neonatal jaundice 10.0
24 syphilis 10.0
25 rare hereditary hemochromatosis 10.0
26 glucosephosphate dehydrogenase deficiency 10.0 G6PD FYB1
27 iron deficiency anemia 10.0 G6PD EPO
28 hemoglobinopathy 10.0 RHCE G6PD EPO
29 kernicterus 10.0 RHD RHCE G6PD
30 gestational choriocarcinoma 10.0 CSH2 CSH1
31 sickle cell disease 10.0 RHD G6PD EPO
32 testicular trophoblastic tumor 10.0 CSH2 CSH1
33 hereditary elliptocytosis 10.0 RHD RHCE G6PD
34 choriocarcinoma of ovary 10.0 CSH2 CSH1
35 otopalatodigital syndrome spectrum disorder 10.0 RHD RHCE FYB1
36 melnick-needles syndrome 9.9 RHD RHCE FYB1
37 supine hypotensive syndrome 9.9 CSH2 CSH1
38 placenta praevia 9.9 CSH2 CSH1
39 epithelioid trophoblastic tumor 9.9 CSH2 CSH1
40 rete ovarii adenoma 9.9 CSH2 CSH1
41 rete ovarii benign neoplasm 9.9 CSH2 CSH1
42 beta-thalassemia 9.9 RHD G6PD EPO
43 hemoglobin h disease 9.9 G6PD EPO
44 placental site trophoblastic tumor 9.9 CSH2 CSH1
45 cockayne syndrome b 9.9 CSH2 CSH1
46 orofaciodigital syndrome viii 9.9 RHCE AFP
47 persistent fetal circulation syndrome 9.9 CSH2 CSH1
48 congenital hemolytic anemia 9.8 G6PD EPO
49 hemolytic anemia 9.8 RHD RHCE G6PD EPO
50 patau syndrome 9.8 RHD RHCE AFP

Graphical network of the top 20 diseases related to Rh Isoimmunization:



Diseases related to Rh Isoimmunization

Symptoms & Phenotypes for Rh Isoimmunization

GenomeRNAi Phenotypes related to Rh Isoimmunization according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.8 AFP EPO G6PD

Drugs & Therapeutics for Rh Isoimmunization

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Minimally Invasive Management of Rh Alloimmunization: Can Amniotic Fluid DeltaOD450 Measurements Be Replaced by Doppler Studies? Completed NCT00295516 Phase 3

Search NIH Clinical Center for Rh Isoimmunization

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Rho(D) Immune Globulin, human

Cochrane evidence based reviews: rh isoimmunization

Genetic Tests for Rh Isoimmunization

Anatomical Context for Rh Isoimmunization

MalaCards organs/tissues related to Rh Isoimmunization:

40
Placenta, Thyroid, Fetal Lung, Bone Marrow, Fetal Thyroid, Pancreatic Islet

Publications for Rh Isoimmunization

Articles related to Rh Isoimmunization:

(show top 50) (show all 374)
# Title Authors PMID Year
1
Management of late anemia in Rhesus hemolytic disease: use of recombinant human erythropoietin (a pilot study). 54 61
8726237 1996
2
Erythropoietin in human fetuses with immune hemolytic anemia and hydrops fetalis. 61 54
8355933 1993
3
Prevalence of rhesus D-negative blood type and the challenges of rhesus D immunoprophylaxis among obstetric population in Ethiopia: a systematic review and meta-analysis. 61
33531050 2021
4
An Unusual Case of Hemolytic Disease of Newborn Due to ABO and Rh Isoimmunization. 61
33489535 2020
5
Severe neonatal hyperbilirubinemia in the southeast region of Turkey 61
31731336 2020
6
Evaluation of Rh-Hemolytic Disease in Neonates and Management with Early Intensive Phototherapy in the Neonatal Intensive Care Unit. 61
31199484 2020
7
Rhesus Isoimmunization: Late-onset Hemolytic Disease of the Newborn Without Jaundice. 61
32042531 2020
8
Hyperbilirubinemia in Preterm Infants Admitted to Neonatal Intensive Care Units in Ethiopia. 61
33457466 2020
9
Rh-incompatible hemolytic disease of the newborn in Hefei. 61
31667170 2019
10
A Multicenter, Randomized, Open-Label Trial Comparing the Efficacy and Safety of Monoclonal Anti-Rh (D) Immunoglobulin with Polyclonal Anti-Rh (D) Immunoglobulin for the Prevention of Maternal Rh-Isoimmunization. 61
31598044 2019
11
Hemolytic anemia caused by non-D minor blood incompatibilities in a newborn. 61
31692740 2019
12
An early, customized low-glycemic-index diet prevents adverse pregnancy outcomes in overweight/obese women. 61
29083138 2018
13
Maternal-fetal Rhesus (Rh) factor incompatibility in Arar, northern Saudi Arabia. 61
29560141 2017
14
Discordant intrauterine transfusion in dichorionic twin pregnancy with Rh isoimmunization. 61
29153312 2017
15
Rh isoimmunized pregnancy managed noninvasively: A report of two cases. 61
28251113 2017
16
[Neonatal Morbidity in Term Newborns Born by Elective Cesarean Section]. 61
26667863 2015
17
A Doppler velocimetry evaluation of intestinal blood flow characteristics in neonates receiving intravenous immunoglobulin therapy: a prospective observational study. 61
25598445 2015
18
Antenatal Maternal Serum IAT Titer and Fetal Outcome in Rh Isoimmunized Pregnancies. 61
25548460 2015
19
[THE FETAL MIDDLE CEREBRAL ARTERY PEAK SYSTOLIC VELOCITY AS A PEDICTOR OF FETAL ANEMIA IN RH-ALLOIMMUNIZED PREGNANCY]. 61
26410952 2015
20
Management of hypersensitivity reactions to anti-D immunoglobulin preparations. 61
25066207 2014
21
Hearing and neurological impairment in children with history of exchange transfusion for neonatal hyperbilirubinemia. 61
24678325 2014
22
Congenital portosystemic venous shunt in a preterm Rh-isoimmunized infant. 61
23389350 2013
23
Evolving trends: hyperbilirubinemia among newborns delivered to rh negative mothers in southern India. 61
24392385 2013
24
[Cavernous transformation of portal vein]. 61
23211206 2012
25
Comparison between two treatment protocols with recombinant human erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-isoimmunization. 61
23173411 2012
26
Refractory cholestasis presenting as cholangiolitis in an Rh (E)-incompatible neonate. 61
21040076 2012
27
Desferrioxamine treatment of iron overload secondary to RH isoimmunization and intrauterine transfusion in a newborn infant. 61
21735053 2011
28
The effectiveness of recombinant human erythropoietin (EPO) treatment in a neonate with hyporegenerative anemia following Rh isoimmunization in spite of normal serum Epo level. 61
21875319 2011
29
[Analysis and perinatal outcome after intravascular transfusion]. 61
21966826 2011
30
[An analysis of RHD zygosity of Rh(D)-positive Chinese Han population]. 61
21287505 2011
31
Rh isoimmunization in Sub-Saharan Africa indicates need for universal access to anti-RhD immunoglobulin and effective management of D-negative pregnancies. 61
21270966 2010
32
[Erythropoietin treatment for late anaemia after haemolytic disease of the newborn]. 61
20970396 2010
33
Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates. 61
20628321 2010
34
Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization. 61
20216236 2010
35
Massive myocardial infarction in a full-term newborn: a case report. 61
20634906 2010
36
Incidence, causes and pregnancy outcomes of hydrops fetalis at Srinagarind Hospital, 1996-2005: a 10-year review. 61
19459517 2009
37
Growth-promoting effect of Rh(D) antibody on human pancreatic islet cells. 61
18544617 2008
38
Successful pregnancy in a patient with severe combined immunodeficiency syndrome treated with bone marrow transplantation. 61
18669756 2008
39
Spontaneous ovarian hyperstimulation in a naturally conceived pregnancy with uncontrolled hypothyroidism. 61
18238999 2008
40
Intraperitoneal transfusion in severe, early-onset Rh isoimmunization. 61
17906023 2007
41
Severe hemolytic disease of the newborn due to anti-Cw. 61
16260563 2005
42
[Persistent neonatal hyperbilirubinemia resulting from Gilbert's syndrome in association with RhD hemolytic disease]. 61
16247547 2005
43
A randomized, triple-blind, placebo-controlled trial of prophylactic oral phenobarbital to reduce the need for phototherapy in G6PD-deficient neonates. 61
15716985 2005
44
Intrauterine fetal transfusion. 61
15711685 2004
45
Prevention and management of RhD isoimmunization. 61
15519425 2004
46
Fetal Doppler velocimetry. 61
15062454 2004
47
Bilateral mesial temporal sclerosis and kernicterus. 61
15091133 2004
48
Noninvasive management of Rh partial null (D--) to supplement traditional management of Rh isoimmunization. 61
14607036 2003
49
[Transvaginal bleeding in pregnancy, as risk factor of Rhesus-D antigen isoimmunization]. 61
14974293 2003
50
Rh negative status and isoimmunization update: a case-based approach to care. 61
12959478 2003

Variations for Rh Isoimmunization

Expression for Rh Isoimmunization

Search GEO for disease gene expression data for Rh Isoimmunization.

Pathways for Rh Isoimmunization

Pathways related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.2 EPO CSH2 CSH1

GO Terms for Rh Isoimmunization

Biological processes related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to nutrient levels GO:0031667 9.46 CSH2 CSH1
2 positive regulation of JAK-STAT cascade GO:0046427 9.43 CSH2 CSH1
3 animal organ development GO:0048513 9.4 CSH2 CSH1
4 erythrocyte maturation GO:0043249 9.37 G6PD EPO
5 growth hormone receptor signaling pathway GO:0060396 9.32 CSH2 CSH1
6 positive regulation of growth GO:0045927 9.26 CSH2 CSH1
7 ammonium transmembrane transport GO:0072488 9.16 RHD RHCE
8 ammonium transport GO:0015696 8.96 RHD RHCE
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 8.8 EPO CSH2 CSH1

Molecular functions related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 EPO CSH2 CSH1
2 ammonium transmembrane transporter activity GO:0008519 8.96 RHD RHCE
3 growth hormone receptor binding GO:0005131 8.62 CSH2 CSH1

Sources for Rh Isoimmunization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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