MCID: RHB002
MIFTS: 39

Rhabdoid Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Rhabdoid Meningioma

MalaCards integrated aliases for Rhabdoid Meningioma:

Name: Rhabdoid Meningioma 12 15 73
Papillary Meningioma 12 55 73
Meningioma, Rhabdoid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5058
NCIt 50 C6909
SNOMED-CT 68 399469000

Summaries for Rhabdoid Meningioma

MalaCards based summary : Rhabdoid Meningioma, also known as papillary meningioma, is related to chordoma and rhabdoid cancer. An important gene associated with Rhabdoid Meningioma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Donepezil and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and salivary gland, and related phenotypes are Decreased cell migration and Increased proliferation

Related Diseases for Rhabdoid Meningioma

Diseases related to Rhabdoid Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 chordoma 29.2 GFAP SMARCB1 VIM
2 rhabdoid cancer 29.1 SMARCB1 SYP VIM
3 ganglioglioma 28.5 BRAF GFAP SMARCB1 SYP
4 papillary meningioma of the cerebellum 12.0
5 adult papillary meningioma 12.0
6 adenofibroma 10.4 BRAF VIM
7 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
8 extraventricular neurocytoma 10.4 GFAP SYP
9 lung combined type small cell carcinoma 10.4 GFAP SYP
10 primitive neuroectodermal tumor of the cervix uteri 10.4 GFAP VIM
11 juvenile xanthogranuloma 10.4 BRAF VIM
12 cellular ependymoma 10.4 GFAP SYP
13 metanephric adenoma 10.4 BRAF VIM
14 parachordoma 10.4 GFAP VIM
15 gangliocytoma 10.4 GFAP SYP
16 pilomyxoid astrocytoma 10.4 GFAP SYP
17 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP SYP
18 subependymal glioma 10.3 GFAP SYP
19 chiari malformation 10.3 GFAP SYP
20 dysembryoplastic neuroepithelial tumor 10.3 GFAP SYP
21 cerebral neuroblastoma 10.3 GFAP SYP
22 ependymoblastoma 10.3 GFAP VIM
23 myxopapillary ependymoma 10.3 GFAP VIM
24 pineal gland cancer 10.3 GFAP SYP
25 syringoma 10.3 GFAP VIM
26 obstructive hydrocephalus 10.3 GFAP SYP
27 pineocytoma 10.3 GFAP SYP
28 subependymoma 10.3 GFAP SYP
29 childhood oligodendroglioma 10.3 GFAP SYP
30 primary hepatic neuroendocrine carcinoma 10.3 SYP VIM
31 papillary ependymoma 10.3 GFAP SYP
32 perineurioma 10.3 GFAP VIM
33 pineoblastoma 10.3 GFAP SYP
34 subependymal giant cell astrocytoma 10.3 GFAP SYP
35 papilloma of choroid plexus 10.3 GFAP SYP
36 central neurocytoma 10.3 GFAP SYP
37 melanotic medulloblastoma 10.3 GFAP SMARCB1
38 granular cell tumor 10.2 GFAP VIM
39 binswanger's disease 10.2 GFAP SYP
40 cystic teratoma 10.2 GFAP SYP
41 nodular medulloblastoma 10.2 GFAP SMARCB1
42 desmoplastic small round cell tumor 10.2 SYP VIM
43 perivascular epithelioid cell tumor 10.2 SYP VIM
44 sertoli cell tumor 10.2 SYP VIM
45 extraskeletal ewing sarcoma 10.2 SYP VIM
46 glomus tumor 10.2 SYP VIM
47 adult medulloblastoma 10.2 GFAP SYP
48 ganglioneuroma 10.2 GFAP SYP
49 cerebral primitive neuroectodermal tumor 10.1 SYP VIM
50 extraosseous chondrosarcoma 10.1 SMARCB1 SYP

Graphical network of the top 20 diseases related to Rhabdoid Meningioma:



Diseases related to Rhabdoid Meningioma

Symptoms & Phenotypes for Rhabdoid Meningioma

GenomeRNAi Phenotypes related to Rhabdoid Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.13 BRAF NF2 VIM
2 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Rhabdoid Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 BRAF GFAP NF2 SMARCB1 SYP VIM
2 muscle MP:0005369 9.46 BRAF GFAP SMARCB1 VIM
3 nervous system MP:0003631 9.43 BRAF GFAP NF2 SMARCB1 SYP VIM
4 vision/eye MP:0005391 9.02 BRAF GFAP NF2 SMARCB1 VIM

Drugs & Therapeutics for Rhabdoid Meningioma

Drugs for Rhabdoid Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 70)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Donepezil Approved Phase 3 120014-06-4 3152
2
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
3 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
4 Analgesics Phase 3,Phase 2
5 Central Nervous System Depressants Phase 3,Phase 2
6 Adjuvants, Anesthesia Phase 3
7 Cholinergic Agents Phase 3
8 Cholinesterase Inhibitors Phase 3
9 Narcotics Phase 3
10 Neurotransmitter Agents Phase 3
11 Analgesics, Opioid Phase 3
12 Anesthetics Phase 3
13 Nootropic Agents Phase 3,Phase 2
14 Anesthetics, General Phase 3
15 Anesthetics, Intravenous Phase 3
16 Peripheral Nervous System Agents Phase 3,Phase 2
17 Liver Extracts Phase 3,Phase 1
18 Cola Nutraceutical Phase 3,Phase 1
19
Hydroxyurea Approved Phase 2 127-07-1 3657
20
Modafinil Approved, Investigational Phase 2 68693-11-8 4236
21 Piracetam Approved, Investigational Phase 2 7491-74-9
22
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
23
Bevacizumab Approved, Investigational Phase 2 216974-75-3
24
Armodafinil Approved, Investigational Phase 2 112111-43-0
25
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
26
Vatalanib Investigational Phase 2 212141-54-3 151194
27 Etiracetam Investigational Phase 2 33996-58-6
28 Imatinib Mesylate Phase 2 220127-57-1 123596
29 Nucleic Acid Synthesis Inhibitors Phase 2
30 Protein Kinase Inhibitors Phase 2
31 calcium channel blockers Phase 2
32 Alkylating Agents Phase 2,Phase 1
33 Central Nervous System Stimulants Phase 2
34 Neuroprotective Agents Phase 2
35 Cytochrome P-450 CYP3A Inducers Phase 2
36 Tranquilizing Agents Phase 2
37 Angiogenesis Inhibitors Phase 2
38 Angiogenesis Modulating Agents Phase 2
39 Anti-Anxiety Agents Phase 2
40 Antibodies Phase 2
41 Immunoglobulins Phase 2
42 Wakefulness-Promoting Agents Phase 2
43 Antibodies, Monoclonal Phase 2
44 Anticonvulsants Phase 2,Phase 1
45 Protective Agents Phase 2
46 Psychotropic Drugs Phase 2
47 Calcium, Dietary Phase 2
48 Antineoplastic Agents, Alkylating Phase 2,Phase 1
49
Verteporfin Approved, Investigational Phase 1 129497-78-5
50
Trioxsalen Approved Phase 1 3902-71-4 5585

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
3 Hydroxyurea With or Without Imatinib Mesylate in Treating Patients With Recurrent or Progressive Meningioma Unknown status NCT00904735 Phase 2 hydroxyurea;imatinib mesylate
4 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
5 Imatinib Mesylate and Hydroxyurea in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00354913 Phase 2 hydroxyurea;imatinib mesylate
6 Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors Completed NCT01032200 Phase 2 Armodafinil
7 Levetiracetam or Pregabalin in Treating Seizures in Patients Undergoing Chemotherapy and/or Radiation Therapy For Primary Brain Tumors Completed NCT00629889 Phase 2 levetiracetam;pregabalin
8 Vatalanib in Treating Patients With Recurrent or Progressive Meningioma Completed NCT00348790 Phase 2 vatalanib
9 Trabectedin for Recurrent Grade II/III Meningioma Active, not recruiting NCT02234050 Phase 2 Trabectedin
10 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
11 Observation or Radiation Therapy in Treating Patients With Grade I, Grade II, or Grade III Meningioma Active, not recruiting NCT00895622 Phase 2
12 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
13 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
14 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
15 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
16 Study of Tissue Samples From Patients With Glioma or Other Brain Tumors Completed NCT00967200
17 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
18 Stress Reduction Program in Patients With Malignant Brain Tumors and Their Family Caregivers Completed NCT00376818 Not Applicable
19 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
20 Oncological Care for Patients With Meningioma Not yet recruiting NCT02973256
21 Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases Terminated NCT02967380 Not Applicable Gadobenate Dimeglumine;Gadobutrol
22 Yoga Therapy in Treating Patients With Malignant Brain Tumors Terminated NCT01234805 Not Applicable
23 Efficacy of 68Ga-DOTATOC Positron Emission Tomography (PET) CT in Children and Young Adults With Brain Tumors Withdrawn NCT02194452 Not Applicable

Search NIH Clinical Center for Rhabdoid Meningioma

Genetic Tests for Rhabdoid Meningioma

Anatomical Context for Rhabdoid Meningioma

MalaCards organs/tissues related to Rhabdoid Meningioma:

41
Brain, Liver, Salivary Gland, Bone, Lymph Node

Publications for Rhabdoid Meningioma

Articles related to Rhabdoid Meningioma:

(show top 50) (show all 52)
# Title Authors Year
1
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. ( 29682040 )
2018
2
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. ( 29492156 )
2018
3
Ectopic rhabdoid meningioma of the orbit in a child: case report and review of the literature. ( 29726794 )
2018
4
Bilateral rhabdoid meningioma mimicking glioma: an unusual occurrence. ( 28860959 )
2017
5
Rhabdoid Meningioma of Brain - A Rare Aggressive Tumor. ( 28900335 )
2017
6
Rhabdoid Meningioma: Grading and Prognostic Significance of This Uncommon Variant. ( 28521039 )
2017
7
Rhabdoid Meningioma Arising Concurrent in Pulmonary and Intracranial with a Rare Malignant Clinical Progression: Case Report and Literature Review. ( 28797981 )
2017
8
Germline and somatic BAP1 mutations in high-grade rhabdoid meningiomas. ( 28170043 )
2017
9
Recurrent rhabdoid meningioma with lymph node, pulmonary and bone metastases: a diagnostic and therapeutic challenge. ( 26875176 )
2016
10
Recurrent skull base rhabdoid meningioma in an adolescent patient. ( 27841231 )
2016
11
Leptomeningeal Dissemination of Intraventricular Rhabdoid Meningioma: Imaging Findings. ( 27161477 )
2016
12
Rhabdoid meningioma: report of two cases. ( 25859490 )
2015
13
Rhabdoid meningioma in the petroclival region: An atypical meningioma in an atypical site. ( 26425167 )
2015
14
Metastatic rhabdoid meningioma of the parotid - Mimicking primary salivary gland neoplasm. ( 25528037 )
2015
15
Rhabdoid meningioma lacking malignant features: Report of a rare case with review of literature. ( 25972960 )
2015
16
Papillary meningioma in the dog: A clinicopathological case series study. ( 25847284 )
2015
17
Aggressive rhabdoid meningioma with osseous, papillary and chordoma-like appearance. ( 24702318 )
2014
18
Rhabdoid meningioma: analysis of one case. ( 23974967 )
2014
19
Metastatic Rhabdoid Meningioma with BRAF V600E Mutation and Good Response to Personalized Therapy: Case Report and Review of the Literature. ( 25116269 )
2014
20
Papillary meningioma: clinical and histopathological observations. ( 23638219 )
2013
21
Intracranial papillary meningioma: a clinicopathologic study of 30 cases at a single institution. ( 23921710 )
2013
22
Crush cytology of a primary intraspinal rhabdoid papillary meningioma: a case report. ( 24021412 )
2013
23
Primary calcified rhabdoid meningioma of the cranio-cervical junction: A case report and review of literature. ( 23741128 )
2012
24
Identification of CD105 (endoglin)-positive stem-like cells in rhabdoid meningioma. ( 21894449 )
2012
25
Intraparenchymal papillary meningioma of brainstem: case report and literature review. ( 22236763 )
2012
26
Hemorrhagic onset of rhabdoid meningioma after initiating treatment for infertility. ( 22350616 )
2012
27
Pediatric rhabdoid meningioma: a morphological, immunohistochemical, ultrastructural and molecular case study. ( 20408963 )
2011
28
Intraspinal rhabdoid meningioma metastasis to the liver. ( 21349724 )
2011
29
Rhabdoid meningioma: rapid intraoperative diagnosis on squash smears. ( 19941363 )
2010
30
Clinicopathologic analysis of rhabdoid meningioma. ( 20537897 )
2010
31
Rhabdoid meningioma presenting with subependymal and diffuse meningeal involvement but no mass lesion. ( 20800496 )
2010
32
Rhabdoid meningioma in an eight-year-old child. ( 20514784 )
2010
33
Intracerebral cystic rhabdoid meningioma. ( 19427788 )
2009
34
Cystic papillary meningioma with subarachnoid dissemination: a case report and review of the literature. ( 19307065 )
2009
35
Diffuse craniospinal metastases of intraventricular rhabdoid papillary meningioma with glial fibrillary acidic protein expression: a case report. ( 19482417 )
2009
36
Volumetric analysis of a rhabdoid meningioma during preoperative follow-up. A case report. ( 19115677 )
2008
37
Cytologic findings of rhabdoid meningioma in cerebrospinal fluid. ( 18323288 )
2008
38
Rhabdoid meningioma with cranial nerve involvement: case report of a child. ( 18666441 )
2008
39
Intraventricular rhabdoid meningioma. ( 17433689 )
2007
40
Rhabdoid meningioma: clinical features and MR imaging findings in 15 patients. ( 17846191 )
2007
41
Rhabdoid meningioma: a new subtype of malignant meningioma also apt to occur in children. ( 15800791 )
2006
42
INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas. ( 15761491 )
2005
43
Rhabdoid meningioma occurring in an unrelated resection cavity with leptomeningeal carcinomatosis. Case report. ( 15739568 )
2005
44
Rhabdoid meningioma of the tentorium with expression of desmin in a 12-year-old Turner syndrome patient. ( 16025286 )
2005
45
Rhabdoid meningioma diagnosed by imprint cytology. ( 16124182 )
2005
46
Rhabdoid meningioma: intraoperative diagnosis using smear preparation. ( 14595799 )
2003
47
Recurrent Rhabdoid Meningioma: Case Report. ( 15912159 )
2003
48
Rhabdoid meningioma: cytopathologic findings in cerebrospinal fluid. ( 14595800 )
2003
49
Malignant rhabdoid meningioma arising in the setting of preexisting ganglioglioma: a diagnosis supported by fluorescence in situ hybridization. Case report. ( 12507148 )
2002
50
Ultrastructural examination is essential for diagnosis of papillary meningioma. ( 11318897 )
2001

Variations for Rhabdoid Meningioma

Expression for Rhabdoid Meningioma

Search GEO for disease gene expression data for Rhabdoid Meningioma.

Pathways for Rhabdoid Meningioma

Pathways related to Rhabdoid Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 GFAP NF2 SYP
2 10.7 GFAP SYP VIM

GO Terms for Rhabdoid Meningioma

Cellular components related to Rhabdoid Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.26 BRAF NF2 SYP VIM
2 cell body GO:0044297 8.8 BRAF GFAP NF2

Biological processes related to Rhabdoid Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.4 GFAP VIM
2 positive regulation of stress fiber assembly GO:0051496 9.37 BRAF NF2
3 long-term synaptic potentiation GO:0060291 9.32 BRAF GFAP
4 astrocyte development GO:0014002 9.26 GFAP VIM
5 intermediate filament organization GO:0045109 9.16 GFAP VIM
6 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
7 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Rhabdoid Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.92 BRAF GFAP SYP VIM

Sources for Rhabdoid Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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