MCID: RHM001
MIFTS: 62

Rheumatic Fever

Categories: Cardiovascular diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Skin diseases

Aliases & Classifications for Rheumatic Fever

Summaries for Rheumatic Fever

NIH Rare Diseases : 53 Rheumatic fever is an inflammatory condition that may develop after infection with group A Streptococcus bacteria, such as strep throat or scarlet fever. It is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. Early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. Some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. It is not clear why some people who are infected with group A Streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. Treatment usually includes antibiotics and/or anti-inflammatory medications.

MalaCards based summary : Rheumatic Fever, also known as acute rheumatic fever, is related to endocarditis and arthritis, and has symptoms including chorea, fever and arthralgia. An important gene associated with Rheumatic Fever is MBL2 (Mannose Binding Lectin 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Adalimumab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and tonsil, and related phenotypes are gait disturbance and nausea and vomiting

Disease Ontology : 12 A connective tissue disease that develops from an antecedent Group A Streptococcal pharyngeal infection and has symptom carditis, has symptom polyarthritis, has symptom chorea, has symptom erythema marginatum, has symptom subcutaneous nodules, has symptom arthralgia, has symptom prolonged PR interval, and/or has symptom fever.

Wikipedia : 76 Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The... more...

Related Diseases for Rheumatic Fever

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 349)
# Related Disease Score Top Affiliating Genes
1 endocarditis 30.8 IL10 IL6 TNF
2 arthritis 30.7 HLA-DRB1 IL10 IL6 TNF
3 kawasaki disease 30.6 IL10 IL6 MBL2 TNF
4 tonsillitis 30.5 IL2 IL6 TNF
5 rheumatic heart disease 30.4 FCN2 HLA-DQA1 HLA-DRB1 IL10 IL6 MASP2
6 reactive arthritis 30.3 HP IL10 TNF
7 berylliosis 30.1 HLA-DRB1 IL2
8 scabies 30.0 IL10 MBL2
9 pneumonia 30.0 IL10 IL6 MBL2 TNF
10 psoriatic arthritis 29.9 HLA-DRB1 IL6 TNF
11 appendicitis 29.9 IL10 IL6 TNF
12 osteomyelitis 29.9 IL10 IL6 TNF
13 meningitis 29.8 IL10 IL6 MBL2 TNF
14 rubella 29.8 HLA-DRB1 IL10 TNF
15 acute disseminated encephalomyelitis 29.7 HLA-DQA1 HLA-DRB1 IL10
16 viral infectious disease 29.7 IL10 IL2 IL6 TNF
17 rheumatoid arthritis 29.7 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6 TNF
18 rheumatic disease 29.6 HLA-DRB1 IL10 TNF
19 takayasu arteritis 29.6 HLA-DQA1 HLA-DRB1 IL6 TNF
20 brucellosis 29.5 IL10 IL2 IL6 TNF
21 connective tissue disease 29.4 HLA-DQA1 HLA-DRB1 IL10 IL6 TNF
22 toxic shock syndrome 29.3 IL10 IL2 IL6 MYOM2 TNF
23 diabetes mellitus 29.3 HLA-DQA1 HLA-DRB1 IL2 IL6 TNF
24 systemic lupus erythematosus 29.2 FCN3 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6
25 autoimmune disease 29.2 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6 MBL2
26 inflammatory bowel disease 29.0 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6 TNF
27 rheumatic fever-related antigen 12.7
28 sydenham chorea 12.0
29 rheumatic myocarditis 11.7
30 acute articular rheumatism 11.5
31 aortic valve disease 2 11.4
32 rheumatic encephalitis 11.2
33 chorea, childhood-onset, with psychomotor retardation 11.1
34 heart disease 10.9
35 glomerulonephritis 10.6
36 pharyngitis 10.5
37 enthesopathy 10.4
38 atrial standstill 1 10.3
39 adult dermatomyositis 10.3 MBL2 TNF
40 actinic prurigo 10.3 HLA-DRB1 TNF
41 vulvar vestibulitis syndrome 10.3 MBL2 TNF
42 rheumatoid vasculitis 10.3 HLA-DRB1 TNF
43 chronic beryllium disease 10.3 HLA-DRB1 TNF
44 nontuberculous mycobacterial lung disease 10.3 HLA-DRB1 TNF
45 acute poststreptococcal glomerulonephritis 10.3
46 scarlet fever 10.3
47 crohn's colitis 10.3 IL2 TNF
48 farmer's lung 10.3 IL2 TNF
49 recurrent respiratory papillomatosis 10.3 HLA-DRB1 IL2
50 eosinophilia-myalgia syndrome 10.3 HLA-DQA1 HLA-DRB1

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to Rheumatic Fever

Symptoms & Phenotypes for Rheumatic Fever

Symptoms:

12
  • chorea
  • fever
  • arthralgia
  • erythema marginatum
  • subcutaneous nodules
  • polyarthritis
  • carditis
  • prolonged pr interval

Human phenotypes related to Rheumatic Fever:

32 (show all 34)
# Description HPO Frequency HPO Source Accession
1 gait disturbance 32 occasional (7.5%) HP:0001288
2 nausea and vomiting 32 hallmark (90%) HP:0002017
3 constipation 32 occasional (7.5%) HP:0002019
4 chorea 32 frequent (33%) HP:0002072
5 respiratory insufficiency 32 occasional (7.5%) HP:0002093
6 behavioral abnormality 32 occasional (7.5%) HP:0000708
7 arthritis 32 hallmark (90%) HP:0001369
8 fever 32 frequent (33%) HP:0001945
9 fatigue 32 frequent (33%) HP:0012378
10 subcutaneous nodule 32 hallmark (90%) HP:0001482
11 arthralgia 32 frequent (33%) HP:0002829
12 arrhythmia 32 frequent (33%) HP:0011675
13 pallor 32 frequent (33%) HP:0000980
14 abdominal pain 32 frequent (33%) HP:0002027
15 aplasia/hypoplasia of the abdominal wall musculature 32 occasional (7.5%) HP:0010318
16 sinusitis 32 frequent (33%) HP:0000246
17 abnormality of the pleura 32 occasional (7.5%) HP:0002103
18 nephrotic syndrome 32 occasional (7.5%) HP:0000100
19 anorexia 32 hallmark (90%) HP:0002039
20 migraine 32 occasional (7.5%) HP:0002076
21 chest pain 32 frequent (33%) HP:0100749
22 erythema 32 occasional (7.5%) HP:0010783
23 epistaxis 32 occasional (7.5%) HP:0000421
24 pericarditis 32 occasional (7.5%) HP:0001701
25 fasciculations 32 occasional (7.5%) HP:0002380
26 dyslexia 32 occasional (7.5%) HP:0010522
27 dysgraphia 32 occasional (7.5%) HP:0010526
28 macule 32 hallmark (90%) HP:0012733
29 myocarditis 32 frequent (33%) HP:0012819
30 hemiballismus 32 occasional (7.5%) HP:0100248
31 endocarditis 32 frequent (33%) HP:0100584
32 recurrent pharyngitis 32 frequent (33%) HP:0100776
33 abnormal mitral valve morphology 32 frequent (33%) HP:0001633
34 abnormal aortic valve morphology 32 frequent (33%) HP:0001646

MGI Mouse Phenotypes related to Rheumatic Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 FCN1 HLA-DQA1 HP IL10 IL2 IL6

Drugs & Therapeutics for Rheumatic Fever

Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 138)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4 331731-18-1 16219006
2 Antirheumatic Agents Phase 4,Phase 3
3 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
4
leucovorin Approved Phase 3 58-05-9 6006 143
5
Methotrexate Approved Phase 3 59-05-2, 1959-05-2 126941
6
Etanercept Approved, Investigational Phase 3 185243-69-0
7
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
8
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
9
rituximab Approved Phase 3,Not Applicable 174722-31-7 10201696
10
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
11
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
12
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
13
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
14
Azathioprine Approved Phase 3 446-86-6 2265
15
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
16
Leflunomide Approved, Investigational Phase 3 75706-12-6 3899
17
Hydroxychloroquine Approved Phase 3 118-42-3 3652
18
Sulfasalazine Approved Phase 3 599-79-1 5353980 5359476
19
Warfarin Approved Phase 3 81-81-2 6691 54678486
20
Rivaroxaban Approved Phase 3 366789-02-8
21
Phytonadione Approved, Investigational Phase 3 84-80-0 4812 5284607
22
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
23
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
24
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
25
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
26
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
27 Antimetabolites Phase 3,Not Applicable
28 Immunosuppressive Agents Phase 3
29 Vitamin B9 Phase 3
30 Folic Acid Antagonists Phase 3
31 Immunologic Factors Phase 3
32 Vitamin B Complex Phase 3
33 Antimetabolites, Antineoplastic Phase 3
34 Nucleic Acid Synthesis Inhibitors Phase 3
35 Dermatologic Agents Phase 3
36 Folate Phase 3
37 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
38 Gastrointestinal Agents Phase 3,Phase 2
39 Hormone Antagonists Phase 3,Phase 2
40 Hormones Phase 3,Phase 2
41 glucocorticoids Phase 3,Phase 2
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
43 Antineoplastic Agents, Hormonal Phase 3,Phase 2
44 Antiemetics Phase 3,Phase 2
45 Autonomic Agents Phase 3,Phase 2,Phase 1
46
protease inhibitors Phase 3,Phase 2
47 HIV Protease Inhibitors Phase 3,Phase 2
48 Analgesics Phase 3
49 Analgesics, Non-Narcotic Phase 3
50 Anti-Inflammatory Agents, Non-Steroidal Phase 3

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 A Study of Tocilizumab (RoActemra/Actemra) Versus Adalimumab in Patients With Rheumatoid Arthritis Completed NCT01119859 Phase 4 Tocilizumab;Adalimumab;Placebo to tocilizumab;Placebo to adalimumab
2 Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo Unknown status NCT01068405 Phase 3 Methotrexate;Placebo
3 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
4 Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide at 39 Weeks Follow up Completed NCT03390036 Phase 3 Cingal;Triamcinolone Hexacetonide
5 A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis Completed NCT01007435 Phase 3 Tocilizumab;Placebo to tocilizumab;Methotrexate;Placebo to methotrexate
6 Mobile Health in Structural Heart Disease Completed NCT02881398 Phase 2, Phase 3
7 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00578305 Phase 3 Placebo;Methylprednisolone;Methotrexate;Folic acid or folate
8 A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01232569 Phase 3 Tocilizumab 162 mg;Placebo
9 A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa Therapies Completed NCT02097745 Phase 3 methotrexate;rituximab [MabThera/Rituxan]
10 A Long-term Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients With Rheumatoid Arthritis Completed NCT00721123 Phase 3 Tocilizumab
11 An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core Studies Completed NCT00720798 Phase 3 Tocilizumab;Disease-modifying anti-rheumatic drugs;Non-steroidal anti-inflammatory drugs;Oral corticosteroids
12 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority Recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
13 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
14 Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic Patient Unknown status NCT02020668 Phase 2
15 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Unknown status NCT03033199 Phase 2 Probiotic Agent;Dexamethasone
16 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2 Penicillin or Placebo
17 Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
18 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
19 Determining the Impact of Penicillin in Latent RHD: The GOAL Trial Recruiting NCT03346525 Phase 2 intramuscular benzathine penicillin G (BPG) prophylaxis
20 Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
21 Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease Completed NCT00482573 Phase 1
22 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
23 Efficacy of BLIS K12 as Preventive Measure for Rheumatic Children Unknown status NCT02407106 Not Applicable
24 Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments Unknown status NCT01642706
25 Development of Intervention Model for Osteoporosis and Fall Prevention in Taiwan Unknown status NCT01206491
26 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
27 Rheumatic Heart Disease Prevalence in Leon, Nicaragua Unknown status NCT00307112
28 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
29 Study Medication Adherence and Its Determinants in Chronic Disease Through the Example of Methotrexate in Chronic Inflammatory Rheumatism Completed NCT02926560
30 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
31 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
32 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
33 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases Completed NCT01511341 Not Applicable
34 Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases Completed NCT03216616 Not Applicable
35 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
36 Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey Completed NCT01400529
37 Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years Completed NCT02894047
38 C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France Completed NCT02886689 TNF-alpha antagonist and other biotherapy
39 Sarcopenia in Axial and Peripheral Spondyloarthropathies Completed NCT03319264 Not Applicable
40 Association Between Hidradenitis Suppurativa and Spondyloarthritis Completed NCT03668925 Not Applicable
41 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
42 Prevalence of Rheumatic Heart Disease Among Pregnant Women in Kenya Completed NCT03411993
43 Effect of Simvastatin on Cardiac Function Completed NCT01178710 Not Applicable Simvastatin
44 Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes Completed NCT03029117
45 Rheumatic Heart Disease Study in Lusaka Completed NCT02661763
46 Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement Completed NCT02474108 Not Applicable
47 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524 Not Applicable
48 Fertility Study of Women With Chronic Inflammatory Rheumatism Recruiting NCT03452735
49 Cardiovascular Risk and Chronic Inflammatory Rheumatism Recruiting NCT03187444 Not Applicable
50 Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism Recruiting NCT03076866

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

Anatomical Context for Rheumatic Fever

MalaCards organs/tissues related to Rheumatic Fever:

41
Heart, Skin, Tonsil, Brain, T Cells, B Cells, Testes

Publications for Rheumatic Fever

Articles related to Rheumatic Fever:

(show top 50) (show all 1457)
# Title Authors Year
1
The role of social determinants of health in the risk and prevention of group A streptococcal infection, acute rheumatic fever and rheumatic heart disease: A systematic review. ( 29897915 )
2018
2
MBL2 gene polymorphism rs1800450 and rheumatic fever with and without rheumatic heart disease: an Egyptian pilot study. ( 29653582 )
2018
3
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
4
Acute Rheumatic Fever, Kawasaki Disease or Alternative Diagnoses? A Call for the General Paediatrician. ( 29870101 )
2018
5
Acute rheumatic fever presenting as complete heart block: report of an adolescent case and review of literature. ( 29440244 )
2018
6
Predictive performance of six mortality risk scores and the development of a novel model in a prospective cohort of patients undergoing valve surgery secondary to rheumatic fever. ( 29979692 )
2018
7
Rheumatic fever - new diagnostic criteria. ( 29686441 )
2018
8
Acute Rheumatic Fever: Revised Diagnostic Criteria. ( 29851920 )
2018
9
Epidemiologic Impact of the New Guidelines for the Diagnosis of Acute Rheumatic Fever. ( 29605389 )
2018
10
Acute Rheumatic Fever: Revised Diagnostic Criteria. ( 29851921 )
2018
11
Aboriginal children and penicillin injections for rheumatic fever: how much of a problem is injection pain? ( 29168304 )
2018
12
The Jones Criteria for the Diagnosis of Acute Rheumatic Fever: Updated but Not Abandoned. ( 29709345 )
2018
13
Estimating the likely true changes in rheumatic fever incidence using two data sources. ( 29208066 )
2018
14
Delayed Diagnosis of Acute Rheumatic Fever in a Patient with Multiple Emergency Department Visits. ( 29974004 )
2018
15
Transition to adult care for Aboriginal children with rheumatic fever: a review informed by a focussed ethnography in northern Australia. ( 29310752 )
2018
16
Rheumatic fever: The rebound phenomenon returns. ( 29411467 )
2018
17
Syncope due to complete atrioventricular block and treatment with a transient pacemaker in acute rheumatic fever. ( 30459521 )
2018
18
Concurrent diagnosis of infective endocarditis and acute rheumatic fever: A case report. ( 30279878 )
2018
19
Acute rheumatic fever presenting with severe endocarditis involving four valves, and ventricular tachycardia - ERRATUM. ( 30334506 )
2018
20
Acute rheumatic fever presenting with severe endocarditis involving four valves, and ventricular tachycardia. ( 30160648 )
2018
21
A Clear-cut Case of Acute Rheumatic Fever After Group G Streptococcal Pharyngitis in New Zealand. ( 29533349 )
2018
22
Acute rheumatic fever. ( 30025809 )
2018
23
Primary prevention of rheumatic fever in the 21st century: evaluation of a national programme. ( 30060070 )
2018
24
"That Heart Sickness": Young Aboriginal People's Understanding of Rheumatic Fever. ( 30067382 )
2018
25
Wolff-Parkinson-White syndrome presenting with steroid-induced bradycardia in a patient with acute rheumatic fever. ( 30070198 )
2018
26
Paediatric acute rheumatic fever in developed countries: Neglected or negligible disease? Results from an observational study in Lombardy (Italy). ( 30094276 )
2018
27
Streptococcal Serology in Acute Rheumatic Fever Patients: Findings from Two High-income, High Burden Settings. ( 30256313 )
2018
28
An old disease re-emerging: acute rheumatic fever. ( 30287435 )
2018
29
Complete heart block in young adult with acute rheumatic fever. ( 30350813 )
2018
30
Poor long-term adherence to secondary penicillin prophylaxis in children with history of rheumatic fever. ( 30415945 )
2018
31
Rheumatic fever: update on the Jones criteria according to the American Heart Association review - 2015. ( 28743364 )
2017
32
Emm type distribution of group A streptococcus isolates from the throat swabs of children living in areas with a high (Northland and Gisborne) or low (Palmerston North) incidence of acute rheumatic fever. ( 28796768 )
2017
33
Using preceding hospital admissions to identify children at risk of developing acute rheumatic fever. ( 29168244 )
2017
34
Can We Eliminate Rheumatic Fever and Premature Deaths From RHD? ( 28552220 )
2017
35
Enablers and barriers to secondary prophylaxis for rheumatic fever among MA8ori aged 14-21 in New Zealand: a framework method study. ( 29149897 )
2017
36
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. ( 29269013 )
2017
37
Acute rheumatic fever: clinical profile in children in western Ukraine. ( 28616087 )
2017
38
Acute rheumatic fever and isolated myocarditis. ( 28560960 )
2017
39
Rheumatic fever as an indicator of child health. ( 28796766 )
2017
40
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
41
MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study. ( 28576308 )
2017
42
Prescribing for people with acute rheumatic fever. ( 28507400 )
2017
43
WhA8nau perceptions and experiences of acute rheumatic fever diagnosis for MA8ori in Northland, New Zealand. ( 29121626 )
2017
44
Clinical management and patient persistence with antibiotic course in suspected group A streptococcal pharyngitis for primary prevention of rheumatic fever: the perspective from a New Zealand emergency department. ( 28617790 )
2017
45
Atrial fibrillation 50 years after acute rheumatic fever as the first manifestation of rheumatic mitral stenosis. ( 28405095 )
2017
46
Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers. ( 29067978 )
2017
47
Rheumatic Fever Presenting as Recurrent Pericarditis and Cardiac Tamponade. ( 28720034 )
2017
48
Acute rheumatic fever and exposure to poor housing conditions in New Zealand: A descriptive study. ( 28052445 )
2017
49
Erratum in: Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 28584595 )
2017
50
Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa. ( 28430286 )
2017

Variations for Rheumatic Fever

Expression for Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for Rheumatic Fever

Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 FCN1 FCN2 FCN3 HLA-DQA1 HLA-DRB1 HP
2
Show member pathways
13.25 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6 TNF
3
Show member pathways
12.91 IL10 IL2 IL6 MBL2 TNF
4
Show member pathways
12.74 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6 TNF
5
Show member pathways
12.72 HLA-DQA1 HLA-DRB1 IL2 IL6 TNF
6
Show member pathways
12.53 HLA-DQA1 HLA-DRB1 IL10 IL2 TNF
7
Show member pathways
12.5 IL10 IL2 IL6 TNF
8
Show member pathways
12.35 IL10 IL2 IL6 TNF
9
Show member pathways
12.34 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6 TNF
10 12.28 HLA-DQA1 HLA-DRB1 IL2 IL6 TNF
11 12.23 HLA-DQA1 HLA-DRB1 IL6 TNF
12
Show member pathways
12.18 IL10 IL2 IL6 TNF
13
Show member pathways
12.18 HLA-DQA1 HLA-DRB1 IL10 TNF
14
Show member pathways
12.12 IL10 IL2 IL6 TNF
15 12.08 IL10 IL6 TNF
16 12.04 HLA-DQA1 HLA-DRB1 MBL2
17 12.02 HLA-DQA1 HLA-DRB1 IL10 IL6 TNF
18
Show member pathways
11.98 FCN2 FCN3 MASP2 MBL2
19
Show member pathways
11.95 IL10 IL2 IL6 TNF
20 11.93 IL2 IL6 TNF
21 11.91 IL10 IL6 TNF
22 11.88 IL10 IL2 IL6 TNF
23
Show member pathways
11.82 FCN1 FCN2 FCN3 MASP2 MBL2
24 11.81 IL10 IL6 TNF
25 11.8 IL10 IL2 IL6
26 11.78 HLA-DQA1 HLA-DRB1 IL6 TNF
27 11.73 IL10 IL2 TNF
28 11.71 HLA-DQA1 HLA-DRB1 IL6 TNF
29 11.7 IL10 IL6 TNF
30
Show member pathways
11.61 IL2 IL6 TNF
31 11.6 IL10 IL2 IL6 TNF
32 11.56 IL10 IL2 IL6 TNF
33 11.51 IL2 IL6 TNF
34 11.48 IL10 IL6 TNF
35 11.48 IL10 IL6 TNF
36 11.45 HP IL6 TNF
37 11.29 IL10 IL6 TNF
38 11.28 IL10 IL6 TNF
39 11.13 IL10 IL2 IL6 TNF
40 11.1 HLA-DQA1 HLA-DRB1 IL10 MASP2 MBL2
41 11.03 IL6 TNF
42 10.96 IL6 TNF
43 10.48 HLA-DRB1 IL10 IL2 IL6 TNF

GO Terms for Rheumatic Fever

Cellular components related to Rheumatic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 HP IL10 IL2 IL6 MASP2 MBL2
2 blood microparticle GO:0072562 9.5 FCN2 FCN3 HP
3 extracellular region GO:0005576 9.32 FCN1 FCN2 FCN3 HP IL10 IL2
4 MHC class II protein complex GO:0042613 9.26 HLA-DQA1 HLA-DRB1
5 collagen trimer GO:0005581 9.26 FCN1 FCN2 FCN3 MBL2

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.94 IL10 IL2 IL6 TNF
2 proteolysis GO:0006508 9.91 FCN1 FCN2 FCN3 HP MASP2 MBL2
3 innate immune response GO:0045087 9.89 FCN1 FCN2 FCN3 MASP2 MBL2
4 cytokine-mediated signaling pathway GO:0019221 9.88 IL10 IL2 IL6 TNF
5 defense response to bacterium GO:0042742 9.85 HP IL10 MBL2 TNF
6 immune response GO:0006955 9.85 HLA-DQA1 HLA-DRB1 IL10 IL2 IL6 TNF
7 cellular response to lipopolysaccharide GO:0071222 9.82 IL10 IL6 TNF
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 IL10 IL6 TNF
9 response to organic substance GO:0010033 9.77 HP IL10 TNF
10 response to glucocorticoid GO:0051384 9.71 IL10 IL6 TNF
11 defense response to Gram-positive bacterium GO:0050830 9.71 FCN2 IL6 MBL2 TNF
12 negative regulation of neurogenesis GO:0050768 9.64 IL6 TNF
13 positive regulation of chemokine production GO:0032722 9.63 IL6 TNF
14 negative regulation of viral entry into host cell GO:0046597 9.63 FCN1 FCN3
15 acute-phase response GO:0006953 9.63 HP IL6 MBL2
16 positive regulation of glial cell proliferation GO:0060252 9.62 IL6 TNF
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL10 TNF
18 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.61 HLA-DQA1 HLA-DRB1
19 positive regulation of immunoglobulin secretion GO:0051024 9.6 IL2 IL6
20 negative regulation of lipid storage GO:0010888 9.58 IL6 TNF
21 opsonization GO:0008228 9.57 FCN2 MBL2
22 endothelial cell apoptotic process GO:0072577 9.56 IL10 TNF
23 immune system process GO:0002376 9.56 FCN1 FCN2 FCN3 HLA-DQA1 HLA-DRB1 IL2
24 complement activation GO:0006956 9.55 FCN1 FCN2 FCN3 MASP2 MBL2
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.52 IL10 TNF
26 positive regulation of neuroinflammatory response GO:0150078 9.51 IL6 TNF
27 negative regulation of growth of symbiont in host GO:0044130 9.5 IL10 MBL2 TNF
28 receptor biosynthetic process GO:0032800 9.48 IL10 TNF
29 recognition of apoptotic cell GO:0043654 9.43 FCN1 FCN2 FCN3
30 complement activation, lectin pathway GO:0001867 9.02 FCN1 FCN2 FCN3 MASP2 MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.54 IL10 IL2 IL6
2 cytokine activity GO:0005125 9.46 IL10 IL2 IL6 TNF
3 calcium-dependent protein binding GO:0048306 9.43 FCN2 MASP2 MBL2
4 carbohydrate binding GO:0030246 9.35 FCN1 FCN2 FCN3 IL2 MBL2
5 MHC class II receptor activity GO:0032395 9.32 HLA-DQA1 HLA-DRB1
6 serine-type endopeptidase activity GO:0004252 9.1 FCN1 FCN2 FCN3 HP MASP2 MBL2

Sources for Rheumatic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
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37 KEGG
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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