MCID: RHM001
MIFTS: 59

Rheumatic Fever

Categories: Cardiovascular diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Rheumatic Fever

Summaries for Rheumatic Fever

GARD : 20 Rheumatic fever is an inflammatory condition that may develop after infection with group A Streptococcus bacteria, such as strep throat or scarlet fever. It is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. Early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. Some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. It is not clear why some people who are infected with group A Streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. Treatment usually includes antibiotics and/or anti-inflammatory medications.

MalaCards based summary : Rheumatic Fever, also known as acute rheumatic fever, is related to pharyngitis and scarlet fever, and has symptoms including chorea, fever and arthralgia. An important gene associated with Rheumatic Fever is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Etanercept and Tofacitinib have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotypes are nausea and vomiting and arthritis

Disease Ontology : 12 A connective tissue disease that develops from an antecedent Group A Streptococcal pharyngeal infection and has symptom carditis, has symptom polyarthritis, has symptom chorea, has symptom erythema marginatum, has symptom subcutaneous nodules, has symptom arthralgia, has symptom prolonged PR interval, and/or has symptom fever.

Wikipedia : 73 Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The... more...

Related Diseases for Rheumatic Fever

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 832)
# Related Disease Score Top Affiliating Genes
1 pharyngitis 31.6 TNF MYOM2 IL6 HLA-DRB1
2 scarlet fever 31.1 TNF MYOM2 ALB
3 glomerulonephritis 31.1 MBL2 ICAM1 ALB ACE
4 infective endocarditis 31.0 TNF TLR2 IL6 FCGR2A
5 pericarditis 30.7 TNF IL6 ALB ACE
6 purpura 30.7 TNF IL6 IL10 ACE
7 spondylitis 30.6 TNF IL6 IL10
8 pericardial effusion 30.6 IL6 ALB ACE
9 temporal arteritis 30.6 TNF IL6 IL2 HLA-DRB1
10 congestive heart failure 30.5 TNF IL6 ALB ACE
11 rheumatic heart disease 30.5 TNF TLR2 MYOM2 MBL2 IL6 IL10
12 reactive arthritis 30.5 TNF TLR2 IL6 IL10 HP HLA-DRB1
13 kawasaki disease 30.5 TNF MBL2 IL6 IL10 FCGR2A ALB
14 allergic disease 30.4 TNF TLR2 IL6 IL2 IL10
15 scabies 30.4 MBL2 IL1A IL10
16 spondyloarthropathy 1 30.4 TNF IL6 HP
17 tonsillitis 30.3 TNF TLR2 IL6 IL2 IL1A IL10
18 endocarditis 30.3 TNF TLR2 IL6 IL1A IL10 FCGR2A
19 myelitis 30.3 TNF IL6 IL10
20 dermatitis herpetiformis 30.3 TNF IL10 HLA-DQB1 HLA-DQA1
21 heart valve disease 30.2 MYOM2 ALB ACE
22 vasculitis 30.2 TNF MBL2 IL6 ICAM1
23 exanthem 30.2 TNF IL6 IL2 IL10 ALB ACE
24 fasciitis 30.2 TNF MYOM2 IL6 IL2
25 lyme disease 30.2 TNF TLR2 IL6 HLA-DRB1 HLA-DQB1
26 lupus erythematosus 30.2 TNF IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 FCN3
27 cardiogenic shock 30.1 TNF IL6
28 berylliosis 30.1 IL2 HLA-DRB1 ACE
29 erysipelas 30.1 TNF MYOM2 IL6 IL2
30 iritis 30.1 TNF IL6 IL10 ACE
31 acute disseminated encephalomyelitis 30.1 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
32 appendicitis 30.0 TNF IL6 IL2 IL10 ALB
33 necrotizing fasciitis 30.0 MYOM2 IL6 IL2 ALB
34 henoch-schoenlein purpura 30.0 ICAM1 ALB ACE
35 brucellosis 30.0 TNF IL6 IL2 IL10
36 urticaria 30.0 TNF IL6 IL10 ACE
37 goodpasture syndrome 30.0 HLA-DRB1 FCGR2A ALB
38 toxic shock syndrome 30.0 TNF TLR2 MYOM2 IL6 IL2 IL10
39 relapsing polychondritis 30.0 IL6 IL2 IL10
40 carpal tunnel syndrome 29.9 IL6 IL2 ACE
41 retinal artery occlusion 29.9 IL6 IL10 ACE
42 osteomyelitis 29.9 TNF TLR2 IL6 IL1A IL10
43 myocarditis 29.9 TNF IL6 IL2 IL10 ICAM1 HLA-DQB1
44 iridocyclitis 29.9 TNF IL6 IL10 ACE
45 stomatitis 29.9 TNF IL6 IL2 IL10
46 thyroiditis 29.9 TNF IL6 IL2 IL10 HLA-DRB1
47 encephalitis 29.9 TNF TLR2 IL6 IL10
48 aseptic meningitis 29.9 TNF IL1A IL10
49 juvenile rheumatoid arthritis 29.9 TNF IL6 IL2 IL10 HLA-DRB1 HLA-DQB1
50 streptococcal toxic-shock syndrome 29.9 TNF MYOM2 IL6 IL2

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to Rheumatic Fever

Symptoms & Phenotypes for Rheumatic Fever

Human phenotypes related to Rheumatic Fever:

31 (show all 34)
# Description HPO Frequency HPO Source Accession
1 nausea and vomiting 31 hallmark (90%) HP:0002017
2 arthritis 31 hallmark (90%) HP:0001369
3 subcutaneous nodule 31 hallmark (90%) HP:0001482
4 anorexia 31 hallmark (90%) HP:0002039
5 macule 31 hallmark (90%) HP:0012733
6 chorea 31 frequent (33%) HP:0002072
7 fatigue 31 frequent (33%) HP:0012378
8 fever 31 frequent (33%) HP:0001945
9 sinusitis 31 frequent (33%) HP:0000246
10 abnormal aortic valve morphology 31 frequent (33%) HP:0001646
11 pallor 31 frequent (33%) HP:0000980
12 abdominal pain 31 frequent (33%) HP:0002027
13 arthralgia 31 frequent (33%) HP:0002829
14 arrhythmia 31 frequent (33%) HP:0011675
15 abnormal mitral valve morphology 31 frequent (33%) HP:0001633
16 myocarditis 31 frequent (33%) HP:0012819
17 endocarditis 31 frequent (33%) HP:0100584
18 chest pain 31 frequent (33%) HP:0100749
19 recurrent pharyngitis 31 frequent (33%) HP:0100776
20 gait disturbance 31 occasional (7.5%) HP:0001288
21 constipation 31 occasional (7.5%) HP:0002019
22 respiratory insufficiency 31 occasional (7.5%) HP:0002093
23 behavioral abnormality 31 occasional (7.5%) HP:0000708
24 aplasia/hypoplasia of the abdominal wall musculature 31 occasional (7.5%) HP:0010318
25 nephrotic syndrome 31 occasional (7.5%) HP:0000100
26 dysgraphia 31 occasional (7.5%) HP:0010526
27 epistaxis 31 occasional (7.5%) HP:0000421
28 pericarditis 31 occasional (7.5%) HP:0001701
29 migraine 31 occasional (7.5%) HP:0002076
30 fasciculations 31 occasional (7.5%) HP:0002380
31 dyslexia 31 occasional (7.5%) HP:0010522
32 erythema 31 occasional (7.5%) HP:0010783
33 hemiballismus 31 occasional (7.5%) HP:0100248
34 abnormal pleura morphology 31 occasional (7.5%) HP:0002103

Symptoms:

12
  • chorea
  • fever
  • arthralgia
  • prolonged pr interval
  • carditis
  • polyarthritis
  • erythema marginatum
  • subcutaneous nodules

GenomeRNAi Phenotypes related to Rheumatic Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.32 IL10 IL1A TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.32 ACE HLA-DQB1 ICAM1 IL10 IL2 TNF
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-3 9.32 ICAM1

MGI Mouse Phenotypes related to Rheumatic Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ACE ALB HLA-DQB1 HP ICAM1 IL10
2 hematopoietic system MP:0005397 10.13 ACE FCGR2A HLA-DQA1 HLA-DQB1 HP ICAM1
3 homeostasis/metabolism MP:0005376 10.1 ACE ALB FCGR2A HLA-DQB1 HP ICAM1
4 endocrine/exocrine gland MP:0005379 10.07 ACE ALB HLA-DQA1 HLA-DQB1 ICAM1 IL10
5 immune system MP:0005387 10.06 ACE ALB FCGR2A FCN1 HLA-DQA1 HLA-DQB1
6 digestive/alimentary MP:0005381 10.01 ALB HLA-DQB1 ICAM1 IL10 IL2 IL6
7 liver/biliary system MP:0005370 9.61 ACE ALB HLA-DQB1 HP IL10 IL2
8 neoplasm MP:0002006 9.32 ACE ALB HP ICAM1 IL10 IL1A

Drugs & Therapeutics for Rheumatic Fever

Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4 185243-69-0
2
Tofacitinib Approved, Investigational Phase 4 477600-75-2
3 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
4 Gastrointestinal Agents Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Analgesics Phase 4
7 Antirheumatic Agents Phase 4
8 Immunologic Factors Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4
11 Protein Kinase Inhibitors Phase 4
12
Abatacept Approved 332348-12-6 10237
13
rituximab Approved 174722-31-7 10201696
14
Prednisolone acetate Approved, Vet_approved 52-21-1
15
Methylprednisolone Approved, Vet_approved 83-43-2 6741
16
Prednisolone Approved, Vet_approved 50-24-8 5755
17
Prednisolone phosphate Approved, Vet_approved 302-25-0
18
Methylprednisolone hemisuccinate Approved 2921-57-5
19
Methotrexate Approved 1959-05-2, 59-05-2 126941
20
Adalimumab Approved, Experimental 331731-18-1 16219006
21
Allopurinol Approved 315-30-0 2094
22
Febuxostat Approved 144060-53-7 134018
23
Glucosamine Approved, Investigational 3416-24-8 439213
24
Prednisolone hemisuccinate Experimental 2920-86-7
25
Imidacloprid Vet_approved 105827-78-9 86418
26
Uric acid Investigational 69-93-2 1175
27 Bacteriocins
28 Antistreptolysin
29 Janus Kinase Inhibitors
30 Neuroprotective Agents
31 Methylprednisolone Acetate
32 Hormone Antagonists
33 Antiemetics
34 Protective Agents
35 Hormones
36 Vaccines
37 Immunoglobulins
38 Antibodies
39 glucocorticoids
40 penicillins
41 Immunosuppressive Agents

Interventional clinical trials:

(show top 50) (show all 60)
# Name Status NCT ID Phase Drugs
1 Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease. Impact of Antirheumatic Treatment on Antibody Response. Completed NCT03762824 Phase 4
2 Capability of Tofacitinib or Etanercept to Accelerate Clinical Relevant Tapering of Non-steroidal Anti-inflammatory Drugs (NSAID) and Treat-to-target Guided De-escalation of Corticosteroids in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Previous csDMARD Therapy (AcceleRAte) Recruiting NCT04485325 Phase 4 Tofacitinib
3 DOES ETANERCEPT INFLUENCE TWEAK MODULATION OF INFLAMMATION DURING INFLAMMATORY RHEUMATISMS (PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS)? Completed NCT02164214 Phase 3 etanercept Treatment
4 Phase II Study of Physiotherapy in Rheumatoid Arthritis: Randomized Single Blind Wait-list Controlled Trial Unknown status NCT02020668 Phase 2
5 A Block-randomized, Double-blind, Placebo-controlled, Single-dose Escalating, Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
6 Phase I Clinical Trial for Assessment of Safety and Immunogenicity of a Synthetic Vaccine Against Streptococcus Pyogenes in Healthy Volunteers Withdrawn NCT03998592 Phase 1
7 Fertility Study of Women With Chronic Inflammatory Rheumatism Unknown status NCT03452735
8 Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Adherence to Penicillin Secondary Prophylaxis Unknown status NCT03183180
9 Efficacy of Streptococcus Salivarius BLIS (Bacteriocin-like Inhibitory Substance) K12 as Preventive Measure for Rheumatic Children. Unknown status NCT02407106
10 Transversal Study of Correlations Between Pain Catastrophizing Scale (PCS) and RAPID3 Score According to Ten Categories of Conditions Seen in an Outpatient Rheumatology Clinic Unknown status NCT03306784
11 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
12 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
13 Selection of Patients With Chronic Inflammatory Rheumatism Requiring Management During the COVID-19 Pandemia Through an Innovative Organizational Strategy Completed NCT04806867
14 Digitally Assisted High-intensity Interval Training in Inflammatory Rheumatic Disease Patients: Treatment by Man or Machine? Completed NCT04649528
15 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases and Their Family: a Crossover Trial Completed NCT01511341
16 Clinical Audit on the Managment of Rheumatic Fever in Assiut University Children Hospital Completed NCT03281863
17 Study Medication Adherence and Its Determinants in Chronic Disease Through the Example of Methotrexate in Chronic Inflammatory Rheumatism Completed NCT02926560
18 East Arnhem Healthy Skin Project: A Regional Collaboration to Reduce Scabies, Skin Sores and Associated Chronic Diseases, Including Rheumatic Fever and Renal Disease, Among Australian Aboriginal Communities Completed NCT00884728
19 Dynamic Changes in IFN-gamma Plasma Levels Following Anti-TNF Treatment in Patients With Inflammatory Rheumatic Diseases Undergoing Serial QuantiFERON-TB Gold In-Tube Testing: a Prospective Study in a Low Tuberculosis Burden Country Completed NCT01475409
20 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
21 Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases Completed NCT03216616
22 The Genetic Basis of Acquired Heart Disease in Africa Completed NCT02124109
23 Nursing Consultation in Out-patient Clinics for Patients With Inflammatory Rheumatic Disease Completed NCT00403676
24 Better Everyday-life With Heated Pool Exercise Groups for Patients With Inflammatory Rheumatic Diseases Completed NCT01755832
25 Vaccination in Inflammatory Rheumatic Disease (VACCIMIL). The Impact of Antirheumatic Treatment on Antibody Response Completed NCT02240888
26 Cryotherapy and Doppler in Inflammatory Rheumatic Diseases Completed NCT02573298
27 The Use of Complementary and Alternative Medicine Among Outpatients With Inflammatory Rheumatic Diseases in Western Sweden. Completed NCT00665275
28 Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: A Randomised Clinical Trial Completed NCT03248518
29 Morbimortality of Covid-19 in Patients With Chronic Inflammatory Rheumatism Treated With Immunosuppressants Recruiting NCT04426279
30 Cardiovascular Risk and Chronic Inflammatory Rheumatism Recruiting NCT03187444
31 Impact of Association of Individual and Group Therapeutic Education Sessions on the Acquisition of Safety Skills by Patients With Chronic Inflammatory Rheumatism (CIR) Treated With Subcutaneous Biotherapy, Compared to Individual Therapeutic Education Sessions Alone Recruiting NCT03838939
32 Covid-19 in Patients With Chronic Inflammatory Rheumatism, Auto-immune or Auto-inflammatory Rare and Non-rare Diseases : a Retrospective Multicenter Observational Study Recruiting NCT04353609
33 JAKINIB Study: " 'Observational', Multicentre Trial Collecting Prospective and On-going Clinical and Laboratory Data for Patients Treated With JAK Inhibitors for Inflammatory Rheumatism According to EMA." Recruiting NCT04602091
34 Non-interventional Clinical Trial to Establish a Glucocorticoid-induced Osteoporosis Databank for Patients With Chronic Inflammatory Rheumatic Diseases or Psoriasis and Therapy With Glucocorticoids Recruiting NCT02719314 Glucocorticoid treatment
35 Regulatory B Cells in Inflammatory Rheumatisms, Systemic Auto-immune Diseases in Adults and Biomarkers of Response to Biologic Treatments Recruiting NCT01642706
36 Impact of a Nurse's Specific Information on the Acceptability of Biosimilars in Chronic Inflammatory Rheumatism Recruiting NCT04321291
37 Prospective, Non-Interventional, Multicenter, Post-Market Clinical Follow-up Study CoreHip® Recruiting NCT03685110
38 Seroprevalence Study of CoV-2-SARS (COVID-19) Infection in Patients With Chronic Inflammatory Rheumatic Diseases Recruiting NCT04655612
39 Seroprevalence and Clinical Expression of SARS-CoV-2 Infection in Patients With Chronic Inflammatory Rheumatisms and Impact of Immuno-suppressive Drugs on the Persistence of Anti-SARS-CoV2 Antibodies During Two Years of Follow-up Recruiting NCT04530682
40 Characterization of Adalimumab Concentrations in Pediatric Patients With Inflammatory Rheumatic Disease With and Without Methotrexate (ADA in PiRD) Recruiting NCT04042792
41 Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue Diseases Recruiting NCT01387035
42 COVID-19 Infection in Vulnerable Patients With Inflammatory Rheumatic Diseases Recruiting NCT04335747
43 Human Papilloma Virus Vaccination and Chronic Inflammatory Rheumatic Disease. A Cross-sectional Study of Vaccinal Coverage, Barriers and Motivations. Recruiting NCT04180228
44 Identification of New Biomarkers to Improve Diagnostics or Predict Treatment Responses, Adverse Events or Prognosis in Patients With Inflammatory Rheumatic Disease Followed in the Danish Nationwide Quality Registry, DANBIO Recruiting NCT03214263
45 Catastrophism in Chronic Inflammatory Rheumatism Active, not recruiting NCT04174092
46 Prevalence of Ocular Manifestations in Inflammatory Rheumatic Diseases Active, not recruiting NCT03753893
47 Setting up a Pediatric Cohort for Inflammatory Rheumatic Diseases Enrolling by invitation NCT02377245
48 PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS Not yet recruiting NCT04664465
49 Assessment of the Psychological Impact of the COVID19 (SARS-CoV-2) Pandemic on Patients With Chronic Inflammatory Rheumatism According to a Management Strategy in the Rheumatology Department of Limoges University Hospital Not yet recruiting NCT04723407
50 Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected Patients Not yet recruiting NCT04798053

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ACETYLSALICYLATE SODIUM
Aspirin
ASPIRIN PWDR
choline salicylate

Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

Anatomical Context for Rheumatic Fever

MalaCards organs/tissues related to Rheumatic Fever:

40
Heart, Skin, Brain, T Cells, Cortex, Adrenal Cortex, Pituitary

Publications for Rheumatic Fever

Articles related to Rheumatic Fever:

(show top 50) (show all 7104)
# Title Authors PMID Year
1
No association of the TLR2 gene Arg753Gln polymorphism with rheumatic heart disease and Behçet's disease. 61 54
19693643 2009
2
High-producing MBL2 genotypes increase the risk of acute and chronic carditis in patients with history of rheumatic fever. 61 54
18602696 2008
3
Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United States. 54 61
16421785 2006
4
TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. 61 54
15968536 2005
5
Epitopes of group A streptococcal M protein shared with antigens of articular cartilage and synovium. 61 54
2016540 1991
6
Reducing antibiotic prescriptions in children is not associated with higher rate of complications. 61
33145703 2021
7
Myocarditis and intracardiac thrombus due to Henoch-Schönlein purpura: case report and literature review. 61
32789615 2021
8
Association of Maternal Autoimmune Disease With Attention-Deficit/Hyperactivity Disorder in Children. 61
33464287 2021
9
The 2020 Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease. 61
33190309 2021
10
An evidence-based scoring system to diagnose acute rheumatic fever with carditis in children. 61
33667575 2021
11
Adherence rates and risk factors for suboptimal adherence to secondary prophylaxis for rheumatic fever. 61
33340191 2021
12
Different antibiotic treatments for group A streptococcal pharyngitis. 61
33728634 2021
13
Rheumatic heart disease in Indigenous young peoples. 61
33705693 2021
14
Investigating inequities in cardiovascular care and outcomes for Queensland Aboriginal and Torres Strait Islander people: protocol for a hospital-based retrospective cohort data linkage project. 61
33741666 2021
15
Relevance of Rheumatic Valvular Heart Disease in the Aetiology of Heart Failure in Contemporary Times. 61
33765372 2021
16
Evolution of epidemiological characteristics of infective endocarditis in Greece. 61
33711517 2021
17
Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever. 61
33639619 2021
18
[NEW ONSET OF VALVULAR HEART DISEASE ALONG WITH ANCIENT PATHOLOGIC FINDING]. 61
33760410 2021
19
The number and activity of CD3+TCR Vα7.2+CD161+ cells are increased in children with acute rheumatic fever. 61
33631279 2021
20
Acute Congestive Heart Failure in a Young Woman. 61
33644737 2021
21
A case report of isolated rheumatic tricuspid regurgitation and pericarditis. 61
33603640 2021
22
Update on SARS-CoV-2 infection in children. 61
33616026 2021
23
Progress in Research of Asymptomatic Primary Mitral Regurgitation Examination Methods: A Review of Literature. 61
33635239 2021
24
Rheumatic heart disease: A review of the current status of global research activity. 61
33333234 2021
25
Update on Post-Streptococcal Reactive Arthritis: Narrative Review of a Forgotten Disease. 61
33569668 2021
26
Study of the relation between serum levels of long-acting penicillin and the inflammatory markers: C-reactive protein and interleukin-6 in patients with chronic rheumatic heart disease. 61
33638745 2021
27
A comprehensive quality evaluation of Fuzi and its processed product through integration of UPLC-QTOF/MS combined MS/MS-based mass spectral molecular networking with multivariate statistical analysis and HPLC-MS/MS. 61
33039630 2021
28
Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. 61
33179113 2021
29
Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice. 61
32841699 2021
30
Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings. 61
33575142 2021
31
Neurologic complications of rheumatic fever. 61
33632442 2021
32
Acute Rheumatic Fever: Where Do We Stand? An Epidemiological Study in Northern Italy. 61
33718402 2021
33
Rising Ethnic Inequalities in Acute Rheumatic Fever and Rheumatic Heart Disease, New Zealand, 2000-2018. 61
33350929 2021
34
Ficolin-3 in rheumatic fever and rheumatic heart disease. 61
33232720 2021
35
The clinical value of ficolin-3 gene polymorphism in rheumatic heart disease. An Egyptian adolescents study. 61
33499929 2021
36
Genetics, Structure, and Function of Group A Streptococcal Pili. 61
33633705 2021
37
Optical Coherence Tomography Findings in Nodular Anterior Scleritis due to Post-Streptococcal Syndrome. 61
33520137 2021
38
Streptococcus-associated vasculitis: A role for antibiotic therapy? 61
33777696 2021
39
Comparison between 2D and 3D Echocardiography in Efficient Detection of Commissural Calcification in Rheumatic Mitral Stenosis. 61
33397845 2021
40
Echocardiographic Screening Detects Rheumatic Heart Disease and Missed Opportunities in the Treatment of Group A Streptococcal Infections in Australian Torres Strait Islander Children. 61
33432909 2021
41
Heart Disease and Pregnancy: The Need for a Twenty-First Century Approach to Care…. 61
32778509 2021
42
Pacific Fono: a community-based initiative to improve rheumatic fever service delivery for Pacific Peoples in South Auckland. 61
33349328 2020
43
Previous Traditional Medicine Use for Sore Throat among Children Evaluated for Rheumatic Fever in Northern Uganda. 61
33319727 2020
44
[Bertolt Brecht. Did he really have rheumatic fever?] 61
32761253 2020
45
Haploinsufficiency of A20 (HA20): updates on the genetics, phenotype, pathogenesis and treatment. 61
31587140 2020
46
The use of cardiac valve procedures for rheumatic heart disease in Australia; a cross-sectional study 2002-2017. 61
33299561 2020
47
A novel aspect may explain the mechanisms of pathogenicity of rheumatic fever, a multifactorial, autoimmune, infectious and inflammatory disorder which "licks the joints and bites the heart": A working hypothesis. 61
33254529 2020
48
Clonidine for pain-related distress in Aboriginal children on a penicillin regimen to prevent recurrence of rheumatic fever. 61
33147979 2020
49
Gender differences in the epidemiology of Rheumatic Fever/Rheumatic heart disease (RF/RHD) patient population of hill state of northern India; 9 years prospective hospital based, HP-RHD registry. 61
33357644 2020
50
School-based Streptococcal A Sore-throat Treatment Programs and Acute Rheumatic Fever Amongst Indigenous Māori: A Retrospective Cohort Study. 61
32502125 2020

Variations for Rheumatic Fever

Expression for Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for Rheumatic Fever

Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 TNF TLR2 MBL2 MASP2 IL6 IL2
2
Show member pathways
13.39 TNF IL6 IL2 IL1A IL10 ICAM1
3
Show member pathways
13.24 TNF TLR2 MBL2 IL6 IL2 IL10
4
Show member pathways
13.23 TNF TLR2 IL2 IL1A HLA-DRB1 HLA-DQB1
5
Show member pathways
12.85 TNF IL6 IL2 IL1A IL10 ICAM1
6 12.84 TNF TLR2 IL6 HLA-DRB1 HLA-DQB1 HLA-DQA1
7
Show member pathways
12.84 TNF TLR2 IL6 IL2 IL1A ICAM1
8
Show member pathways
12.72 TNF TLR2 IL6 IL2 IL1A
9
Show member pathways
12.69 TNF IL2 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
10
Show member pathways
12.65 TNF TLR2 IL6 IL2 IL1A IL10
11
Show member pathways
12.56 TNF TLR2 IL6 IL2 IL1A IL10
12
Show member pathways
12.39 IL2 HLA-DRB1 HLA-DQB1 HLA-DQA1
13
Show member pathways
12.39 TNF IL6 IL2 ICAM1 ALB
14 12.39 TNF IL6 IL2 ICAM1 HLA-DRB1 HLA-DQB1
15
Show member pathways
12.34 TNF IL6 IL2 IL10
16
Show member pathways
12.29 TNF IL6 IL2 IL1A IL10
17
Show member pathways
12.28 TNF TLR2 IL6 IL1A
18
Show member pathways
12.23 TNF IL6 IL2 IL10
19 12.23 TLR2 MBL2 HLA-DRB1 HLA-DQB1 HLA-DQA1 FCGR2A
20 12.2 TNF IL6 IL1A IL10
21
Show member pathways
12.2 TNF TLR2 IL1A IL10 HLA-DRB1 HLA-DQB1
22
Show member pathways
12.18 MBL2 MASP2 FCN3 FCN2
23
Show member pathways
12.18 MBL2 MASP2 FCN3 FCN2 FCN1
24 12.15 ICAM1 HLA-DRB1 HLA-DQB1 HLA-DQA1
25 12.15 TNF IL6 IL2 IL10 FCGR2A
26 12.08 TNF IL6 IL2 IL1A ICAM1 FCGR2A
27 12.07 TNF IL6 IL2 IL10 FCGR2A
28 12.06 TNF TLR2 IL6 IL1A IL10 HLA-DRB1
29 12.05 TNF IL6 IL1A IL10 ICAM1
30 11.97 TNF TLR2 IL6 IL10
31 11.97 TNF IL6 IL1A HLA-DRB1 HLA-DQB1 HLA-DQA1
32 11.96 TNF IL6 IL1A ICAM1
33
Show member pathways
11.85 TNF TLR2 IL6 IL2 IL10
34 11.83 TNF IL6 IL1A IL10
35 11.81 TNF IL6 IL2 IL10
36 11.8 IL6 IL2 ICAM1
37
Show member pathways
11.8 HLA-DRB1 HLA-DQB1 HLA-DQA1
38 11.79 TNF IL2 IL10
39
Show member pathways
11.76 TNF IL6 IL2 IL1A ICAM1
40 11.73 HLA-DRB1 HLA-DQB1 HLA-DQA1
41 11.73 TNF TLR2 IL6 IL10 ICAM1 FCGR2A
42 11.64 TNF TLR2 IL6 IL10 ICAM1
43 11.63 TNF TLR2 IL6
44 11.62 TNF IL6 IL1A IL10 ICAM1
45 11.59 TNF IL6 ICAM1 HP
46 11.57 TNF IL6 IL2
47 11.54 MBL2 MASP2 IL10 ICAM1 HLA-DRB1 HLA-DQB1
48 11.51 TNF IL6 IL1A
49 11.46 TNF IL6 IL10 ICAM1
50 11.43 TNF IL6 IL1A IL10

GO Terms for Rheumatic Fever

Cellular components related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.85 MBL2 ICAM1 FCN3 FCN2 FCN1
2 extracellular region GO:0005576 9.77 TNF MBL2 MASP2 IL6 IL2 IL1A
3 blood microparticle GO:0072562 9.71 HP FCN3 FCN2 ALB
4 endocytic vesicle membrane GO:0030666 9.67 HLA-DRB1 HLA-DQB1 HLA-DQA1
5 ER to Golgi transport vesicle membrane GO:0012507 9.65 HLA-DRB1 HLA-DQB1 HLA-DQA1
6 transport vesicle membrane GO:0030658 9.61 HLA-DRB1 HLA-DQB1 HLA-DQA1
7 collagen trimer GO:0005581 9.56 MBL2 FCN3 FCN2 FCN1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.54 HLA-DRB1 HLA-DQB1 HLA-DQA1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.5 HLA-DRB1 HLA-DQB1 HLA-DQA1
10 extracellular space GO:0005615 9.5 TNF MBL2 MASP2 IL6 IL2 IL1A
11 MHC class II protein complex GO:0042613 9.33 HLA-DRB1 HLA-DQB1 HLA-DQA1

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 10.07 TLR2 MBL2 MASP2 FCN3 FCN2 FCN1
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.91 TNF TLR2 IL6 ICAM1
3 cytokine-mediated signaling pathway GO:0019221 9.88 TNF IL6 IL2 IL1A IL10 ICAM1
4 cellular response to lipopolysaccharide GO:0071222 9.85 TNF IL6 IL1A IL10 ICAM1
5 positive regulation of interleukin-6 production GO:0032755 9.84 TNF TLR2 IL6 IL1A
6 response to insulin GO:0032868 9.83 TLR2 IL10 ICAM1
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 TNF IL6 IL2
8 response to glucocorticoid GO:0051384 9.82 TNF IL6 IL10
9 interferon-gamma-mediated signaling pathway GO:0060333 9.81 ICAM1 HLA-DRB1 HLA-DQB1 HLA-DQA1
10 immune response GO:0006955 9.81 TNF TLR2 IL6 IL2 IL1A IL10
11 positive regulation of cytokine production GO:0001819 9.8 TNF IL1A IL10
12 antigen processing and presentation GO:0019882 9.77 HLA-DRB1 HLA-DQB1 HLA-DQA1
13 positive regulation of chemokine production GO:0032722 9.76 TNF TLR2 IL6
14 acute-phase response GO:0006953 9.75 MBL2 IL6 HP
15 positive regulation of interleukin-8 production GO:0032757 9.73 TNF TLR2 IL6 FCN1
16 positive regulation of JAK-STAT cascade GO:0046427 9.72 TNF IL6 IL10
17 defense response to Gram-positive bacterium GO:0050830 9.72 TNF TLR2 MBL2 IL6 FCN2
18 positive regulation of immunoglobulin production GO:0002639 9.7 IL6 IL2 IL10
19 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.67 TNF IL6 ICAM1
20 response to molecule of bacterial origin GO:0002237 9.66 TLR2 IL10
21 neutrophil mediated immunity GO:0002446 9.65 IL6 ACE
22 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
23 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.65 HLA-DRB1 HLA-DQB1 HLA-DQA1
24 complement activation GO:0006956 9.65 MBL2 MASP2 FCN3 FCN2 FCN1
25 endothelial cell apoptotic process GO:0072577 9.64 TNF IL10
26 vascular endothelial growth factor production GO:0010573 9.63 TNF IL6
27 opsonization GO:0008228 9.63 MBL2 FCN2
28 negative regulation of cytokine production involved in immune response GO:0002719 9.62 TNF IL10
29 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.61 HLA-DRB1 HLA-DQB1
30 positive regulation of plasma cell differentiation GO:1900100 9.57 IL2 IL10
31 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.56 HLA-DRB1 HLA-DQB1
32 recognition of apoptotic cell GO:0043654 9.54 FCN3 FCN2 FCN1
33 immune system process GO:0002376 9.4 TLR2 MBL2 MASP2 IL2 HP HLA-DRB1
34 complement activation, lectin pathway GO:0001867 9.35 MBL2 MASP2 FCN3 FCN2 FCN1

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.26 TNF TLR2 MYOM2 MBL2 MASP2 IL6
2 cytokine activity GO:0005125 9.55 TNF IL6 IL2 IL1A IL10
3 peptide antigen binding GO:0042605 9.5 HLA-DRB1 HLA-DQB1 HLA-DQA1
4 carbohydrate derivative binding GO:0097367 9.37 FCN2 FCN1
5 carbohydrate binding GO:0030246 9.35 MBL2 IL2 FCN3 FCN2 FCN1
6 MHC class II receptor activity GO:0032395 8.8 HLA-DRB1 HLA-DQB1 HLA-DQA1

Sources for Rheumatic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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