MCID: RHM001
MIFTS: 58

Rheumatic Fever

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Rheumatic Fever

Summaries for Rheumatic Fever

NIH Rare Diseases : 53 Rheumatic fever is an inflammatory condition that may develop after infection with group A Streptococcus bacteria, such as strep throat or scarlet fever. It is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. Early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. Some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. It is not clear why some people who are infected with group A Streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. Treatment usually includes antibiotics and/or anti-inflammatory medications.

MalaCards based summary : Rheumatic Fever, also known as acute rheumatic fever, is related to rheumatic disease and rheumatic heart disease. An important gene associated with Rheumatic Fever is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Innate Immune System and Influenza A. The drugs Adalimumab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotypes are nephrotic syndrome and sinusitis

Wikipedia : 76 Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The... more...

Related Diseases for Rheumatic Fever

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 rheumatic disease 31.0 CD40LG HLA-DRB1 TNF
2 rheumatic heart disease 30.7 HLA-DRB1 MASP2 MBL2 MYOM2 TNF
3 berylliosis 30.5 HLA-DRB1 IL2
4 takayasu arteritis 29.9 CD40LG HLA-DRB1 TNF
5 brucellosis 29.7 CD40LG IL2 TNF
6 toxic shock syndrome 29.3 IL2 MYOM2 TLR2 TNF
7 meningitis 29.1 CD40LG MBL2 TLR2 TNF
8 autoimmune disease 28.7 CD40LG HLA-DRB1 IL2 MBL2 TNF
9 rheumatoid arthritis 28.5 CD40LG HLA-DRB1 IL2 TLR2 TNF
10 systemic lupus erythematosus 27.6 CD40LG FCN3 HLA-DRB1 IL2 MBL2 TNF
11 rheumatic fever-related antigen 12.5
12 sydenham chorea 11.8
13 rheumatic myocarditis 11.6
14 acute articular rheumatism 11.6
15 aortic valve disease 2 11.3
16 rheumatic encephalitis 11.1
17 choreatic disease 11.0
18 microscopic polyangiitis 10.8 HLA-DRB1 TNF
19 vulvar vestibulitis syndrome 10.8 MBL2 TNF
20 adult dermatomyositis 10.8 MBL2 TNF
21 beryllium disease 10.8 HLA-DRB1 TNF
22 autoimmune pancreatitis 10.8 HLA-DRB1 TNF
23 chronic beryllium disease 10.8 HLA-DRB1 TNF
24 anca-associated vasculitis 10.8 HLA-DRB1 TNF
25 lichen sclerosus 10.8 HLA-DRB1 TNF
26 actinic prurigo 10.8 HLA-DRB1 TNF
27 sympathetic ophthalmia 10.8 HLA-DRB1 TNF
28 oral tuberculosis 10.7 IL2 TNF
29 poems syndrome 10.7 MYOM2 TNF
30 listeriosis 10.7 MBL2 TNF
31 rheumatoid vasculitis 10.7 HLA-DRB1 TNF
32 autoimmune myocarditis 10.7 IL2 TNF
33 farmer's lung 10.7 IL2 TNF
34 heart disease 10.7
35 recurrent respiratory papillomatosis 10.7 HLA-DRB1 IL2
36 prosthetic joint infection 10.6 MBL2 TLR2
37 clonorchiasis 10.6 IL2 TNF
38 extramedullary plasmacytoma 10.6 IL2 MYOM2
39 crohn's colitis 10.6 IL2 TNF
40 burning mouth syndrome 10.6 IL2 TNF
41 haemophilus influenzae 10.6 TLR2 TNF
42 oligoarticular juvenile idiopathic arthritis 10.6 HLA-DRB1 TNF
43 penicilliosis 10.6 TLR2 TNF
44 posterior uveitis 10.6 IL2 TNF
45 encephalitozoonosis 10.6 CD40LG TNF
46 immunoglobulin g deficiency 10.6 CD40LG MBL2
47 rheumatoid lung disease 10.6 CD40LG TNF
48 miller fisher syndrome 10.6 CD40LG TNF
49 mycobacterium abscessus 10.5 TLR2 TNF
50 melancholia 10.5 HP TNF

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to Rheumatic Fever

Symptoms & Phenotypes for Rheumatic Fever

Human phenotypes related to Rheumatic Fever:

32 (show all 34)
# Description HPO Frequency HPO Source Accession
1 nephrotic syndrome 32 occasional (7.5%) HP:0000100
2 sinusitis 32 frequent (33%) HP:0000246
3 epistaxis 32 occasional (7.5%) HP:0000421
4 behavioral abnormality 32 occasional (7.5%) HP:0000708
5 pallor 32 frequent (33%) HP:0000980
6 gait disturbance 32 occasional (7.5%) HP:0001288
7 arthritis 32 hallmark (90%) HP:0001369
8 subcutaneous nodule 32 hallmark (90%) HP:0001482
9 abnormal mitral valve morphology 32 frequent (33%) HP:0001633
10 abnormal aortic valve morphology 32 frequent (33%) HP:0001646
11 pericarditis 32 occasional (7.5%) HP:0001701
12 fever 32 frequent (33%) HP:0001945
13 nausea and vomiting 32 hallmark (90%) HP:0002017
14 constipation 32 occasional (7.5%) HP:0002019
15 abdominal pain 32 frequent (33%) HP:0002027
16 anorexia 32 hallmark (90%) HP:0002039
17 chorea 32 frequent (33%) HP:0002072
18 migraine 32 occasional (7.5%) HP:0002076
19 respiratory insufficiency 32 occasional (7.5%) HP:0002093
20 abnormality of the pleura 32 occasional (7.5%) HP:0002103
21 fasciculations 32 occasional (7.5%) HP:0002380
22 arthralgia 32 frequent (33%) HP:0002829
23 aplasia/hypoplasia of the abdominal wall musculature 32 occasional (7.5%) HP:0010318
24 dyslexia 32 occasional (7.5%) HP:0010522
25 dysgraphia 32 occasional (7.5%) HP:0010526
26 erythema 32 occasional (7.5%) HP:0010783
27 arrhythmia 32 frequent (33%) HP:0011675
28 fatigue 32 frequent (33%) HP:0012378
29 macule 32 hallmark (90%) HP:0012733
30 myocarditis 32 frequent (33%) HP:0012819
31 hemiballismus 32 occasional (7.5%) HP:0100248
32 endocarditis 32 frequent (33%) HP:0100584
33 chest pain 32 frequent (33%) HP:0100749
34 recurrent pharyngitis 32 frequent (33%) HP:0100776

MGI Mouse Phenotypes related to Rheumatic Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD40LG FCN1 HP IL2 MASP2 MBL2

Drugs & Therapeutics for Rheumatic Fever

Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 135)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4 331731-18-1 16219006
2 Antirheumatic Agents Phase 4,Phase 3
3 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
4
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
5
rituximab Approved Phase 3,Not Applicable 174722-31-7 10201696
6
Hydroxychloroquine Approved Phase 3 118-42-3 3652
7
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
8
Sulfasalazine Approved Phase 3 599-79-1 5353980 5359476
9
Etanercept Approved, Investigational Phase 3 185243-69-0
10
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
11
Leflunomide Approved, Investigational Phase 3 75706-12-6 3899
12
Azathioprine Approved Phase 3 446-86-6 2265
13
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
14
Hyaluronic acid Approved, Vet_approved Phase 3 9004-61-9 53477741
15
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
16
Warfarin Approved Phase 3 81-81-2 6691 54678486
17
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
18
Rivaroxaban Approved Phase 3 366789-02-8
19
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
21
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
22
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
23
Phytonadione Approved, Investigational, Nutraceutical Phase 3 84-80-0 4812 5284607
24 Folic Acid Antagonists Phase 3
25 Dermatologic Agents Phase 3
26 Nucleic Acid Synthesis Inhibitors Phase 3
27 Vitamin B Complex Phase 3
28 Immunosuppressive Agents Phase 3
29 Antimetabolites Phase 3,Not Applicable
30 Antimetabolites, Antineoplastic Phase 3
31 Prednisolone acetate Phase 3
32 Chloroquine diphosphate Phase 3 50-63-5
33 Analgesics Phase 3
34 glucocorticoids Phase 3,Phase 2
35 Methylprednisolone acetate Phase 3
36 Methylprednisolone Hemisuccinate Phase 3
37 Micronutrients Phase 3
38 Gastrointestinal Agents Phase 3,Phase 2
39 Natriuretic Peptide, Brain Phase 2, Phase 3
40 Neuroprotective Agents Phase 3
41 Hematinics Phase 3
42 Analgesics, Non-Narcotic Phase 3
43 Hormone Antagonists Phase 3,Phase 2
44 Trace Elements Phase 3
45 Hormones Phase 3,Phase 2
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
47 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
48 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
49 Vitamins Phase 3
50 Antibodies Phase 3

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 A Study of Tocilizumab (RoActemra/Actemra) Versus Adalimumab in Patients With Rheumatoid Arthritis Completed NCT01119859 Phase 4 Tocilizumab;Adalimumab;Placebo to tocilizumab;Placebo to adalimumab
2 Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo Unknown status NCT01068405 Phase 3 Methotrexate;Placebo
3 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
4 A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid Arthritis Completed NCT01007435 Phase 3 Tocilizumab;Placebo to tocilizumab;Methotrexate;Placebo to methotrexate
5 Mobile Health in Structural Heart Disease Completed NCT02881398 Phase 2, Phase 3
6 A Study of Rituximab (MabThera®/Rituxan®) in Patients With Rheumatoid Arthritis and Inadequate Response to Methotrexate Completed NCT00578305 Phase 3 Placebo;Methylprednisolone;Methotrexate;Folic acid or folate
7 A Study of RoActemra/Actemra (Tocilizumab) Given Subcutaneously in Combination With Traditional DMARDs in Patients With Moderate to Severe Active Rheumatoid Arthritis Completed NCT01232569 Phase 3 Tocilizumab 162 mg;Placebo
8 A Study of the Efficacy and Safety of Re-treatments With Rituximab in Patients With Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-tnfa Therapies Completed NCT02097745 Phase 3 methotrexate;rituximab [MabThera/Rituxan]
9 A Long-term Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients With Rheumatoid Arthritis Completed NCT00721123 Phase 3 Tocilizumab
10 An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core Studies Completed NCT00720798 Phase 3 Tocilizumab;Disease-modifying anti-rheumatic drugs;Non-steroidal anti-inflammatory drugs;Oral corticosteroids
11 Study of Cingal™ for the Relief of Knee Osteoarthritis Compared to Triamcinolone Hexacetonide at 39 Weeks Follow up Enrolling by invitation NCT03390036 Phase 3 Cingal;Triamcinolone Hexacetonide
12 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority Not yet recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
13 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
14 Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic Patient Unknown status NCT02020668 Phase 2
15 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2 Penicillin or Placebo
16 Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
17 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
18 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Recruiting NCT03033199 Phase 2 Probiotic Agent;Dexamethasone
19 Determining the Impact of Penicillin in Latent RHD: The GOAL Trial Not yet recruiting NCT03346525 Phase 2 intramuscular benzathine penicillin G (BPG) prophylaxis
20 Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
21 Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease Completed NCT00482573 Phase 1
22 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
23 Efficacy of BLIS K12 as Preventive Measure for Rheumatic Children Unknown status NCT02407106 Not Applicable
24 Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments Unknown status NCT01642706
25 Development of Intervention Model for Osteoporosis and Fall Prevention in Taiwan Unknown status NCT01206491
26 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
27 Rheumatic Heart Disease Prevalence in Leon, Nicaragua Unknown status NCT00307112
28 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
29 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
30 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
31 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
32 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases Completed NCT01511341 Not Applicable
33 Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases Completed NCT03216616 Not Applicable
34 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
35 Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey Completed NCT01400529
36 Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years Completed NCT02894047
37 C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France Completed NCT02886689 TNF-alpha antagonist and other biotherapy
38 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
39 Effect of Simvastatin on Cardiac Function Completed NCT01178710 Not Applicable Simvastatin
40 Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes Completed NCT03029117
41 Rheumatic Heart Disease Study in Lusaka Completed NCT02661763
42 Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement Completed NCT02474108 Not Applicable
43 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524 Not Applicable
44 Cardiovascular Risk and Chronic Inflammatory Rheumatism Recruiting NCT03187444 Not Applicable
45 Study Medication Adherence and Its Determinants in Chronic Disease Through the Example of Methotrexate in Chronic Inflammatory Rheumatism Recruiting NCT02926560
46 Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism Recruiting NCT03076866
47 Rheumatic Heart Disease School Project Recruiting NCT01550068
48 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109
49 RhEumatiC Heart diseAse Genetics Recruiting NCT02118818
50 Pain Catastrophizing and Routine Assessment of Patient Index Data 3(RAPID3) in Ten Categories of Rheumatology Outpatients Recruiting NCT03306784

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

Anatomical Context for Rheumatic Fever

MalaCards organs/tissues related to Rheumatic Fever:

41
Heart, Skin, Brain, Tonsil, B Cells, Monocytes, Bone

Publications for Rheumatic Fever

Articles related to Rheumatic Fever:

(show top 50) (show all 693)
# Title Authors Year
1
The role of social determinants of health in the risk and prevention of group A streptococcal infection, acute rheumatic fever and rheumatic heart disease: A systematic review. ( 29897915 )
2018
2
MBL2 gene polymorphism rs1800450 and rheumatic fever with and without rheumatic heart disease: an Egyptian pilot study. ( 29653582 )
2018
3
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
4
Acute Rheumatic Fever, Kawasaki Disease or Alternative Diagnoses? A Call for the General Paediatrician. ( 29870101 )
2018
5
Acute rheumatic fever presenting as complete heart block: report of an adolescent case and review of literature. ( 29440244 )
2018
6
Predictive performance of six mortality risk scores and the development of a novel model in a prospective cohort of patients undergoing valve surgery secondary to rheumatic fever. ( 29979692 )
2018
7
Rheumatic fever - new diagnostic criteria. ( 29686441 )
2018
8
Acute Rheumatic Fever: Revised Diagnostic Criteria. ( 29851920 )
2018
9
Epidemiologic Impact of the New Guidelines for the Diagnosis of Acute Rheumatic Fever. ( 29605389 )
2018
10
Acute Rheumatic Fever: Revised Diagnostic Criteria. ( 29851921 )
2018
11
Aboriginal children and penicillin injections for rheumatic fever: how much of a problem is injection pain? ( 29168304 )
2018
12
The Jones Criteria for the Diagnosis of Acute Rheumatic Fever: Updated but Not Abandoned. ( 29709345 )
2018
13
Estimating the likely true changes in rheumatic fever incidence using two data sources. ( 29208066 )
2018
14
Delayed Diagnosis of Acute Rheumatic Fever in a Patient with Multiple Emergency Department Visits. ( 29974004 )
2018
15
Transition to adult care for Aboriginal children with rheumatic fever: a review informed by a focussed ethnography in northern Australia. ( 29310752 )
2018
16
Rheumatic fever: The rebound phenomenon returns. ( 29411467 )
2018
17
A Clear-cut Case of Acute Rheumatic Fever After Group G Streptococcal Pharyngitis in New Zealand. ( 29533349 )
2018
18
Rheumatic fever: update on the Jones criteria according to the American Heart Association review - 2015. ( 28743364 )
2017
19
Emm type distribution of group A streptococcus isolates from the throat swabs of children living in areas with a high (Northland and Gisborne) or low (Palmerston North) incidence of acute rheumatic fever. ( 28796768 )
2017
20
Using preceding hospital admissions to identify children at risk of developing acute rheumatic fever. ( 29168244 )
2017
21
Can We Eliminate Rheumatic Fever and Premature Deaths From RHD? ( 28552220 )
2017
22
Enablers and barriers to secondary prophylaxis for rheumatic fever among MA8ori aged 14-21 in New Zealand: a framework method study. ( 29149897 )
2017
23
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. ( 29269013 )
2017
24
Acute rheumatic fever: clinical profile in children in western Ukraine. ( 28616087 )
2017
25
Acute rheumatic fever and isolated myocarditis. ( 28560960 )
2017
26
Rheumatic fever as an indicator of child health. ( 28796766 )
2017
27
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
28
MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study. ( 28576308 )
2017
29
Prescribing for people with acute rheumatic fever. ( 28507400 )
2017
30
WhA8nau perceptions and experiences of acute rheumatic fever diagnosis for MA8ori in Northland, New Zealand. ( 29121626 )
2017
31
Clinical management and patient persistence with antibiotic course in suspected group A streptococcal pharyngitis for primary prevention of rheumatic fever: the perspective from a New Zealand emergency department. ( 28617790 )
2017
32
Atrial fibrillation 50 years after acute rheumatic fever as the first manifestation of rheumatic mitral stenosis. ( 28405095 )
2017
33
Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers. ( 29067978 )
2017
34
Rheumatic Fever Presenting as Recurrent Pericarditis and Cardiac Tamponade. ( 28720034 )
2017
35
Acute rheumatic fever and exposure to poor housing conditions in New Zealand: A descriptive study. ( 28052445 )
2017
36
Erratum in: Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 28584595 )
2017
37
Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa. ( 28430286 )
2017
38
Evaluation of vitamin D levels in patients with acute rheumatic fever. ( 28680013 )
2017
39
Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm Mimicking Acute Rheumatic Fever: Report of an Unusual Clinical Presentation and Review of Literature. ( 28859047 )
2017
40
Acute rheumatic fever outbreak in southern central European country. ( 27815733 )
2017
41
Eliminating acute rheumatic fever and rheumatic heart disease. ( 28721865 )
2017
42
Atypical Articular Presentations in Indian Children with Rheumatic Fever. ( 28528779 )
2017
43
Penicillin Dried Blood Spot Assay for Use in Patients Receiving Intramuscular Benzathine Penicillin G and Other Penicillin Preparations To Prevent Rheumatic Fever. ( 28559267 )
2017
44
Ventricular dyssynchrony as a marker of latent carditis in children with acute rheumatic fever: A tissue Doppler imaging. ( 29067722 )
2017
45
Is a rheumatic fever register the best surveillance tool to evaluate rheumatic fever control in the Auckland region? ( 28796771 )
2017
46
Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 27867464 )
2016
47
Association between rheumatic fever and Takayasu's arteritis - Case report. ( 27267532 )
2016
48
Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever. ( 27465618 )
2016
49
Tracking isolated myocarditis in a young adult with acute rheumatic fever on cardiac magnetic resonance imaging. ( 27526359 )
2016
50
2016 National Rheumatic Fever Week: The status of rheumatic heart disease in South Africa. ( 27499394 )
2016

Variations for Rheumatic Fever

Expression for Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for Rheumatic Fever

Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CD40LG FCN1 FCN2 FCN3 HLA-DRB1 HP
2
Show member pathways
12.54 HLA-DRB1 IL2 TLR2 TNF
3
Show member pathways
12.44 CD40LG IL2 TLR2 TNF
4 12.33 CD40LG IL2 TLR2 TNF
5
Show member pathways
12.27 CD40LG TLR2 TNF
6
Show member pathways
12.18 HLA-DRB1 IL2 TLR2 TNF
7
Show member pathways
12.03 IL2 TLR2 TNF
8 12 HLA-DRB1 TLR2 TNF
9 11.89 HLA-DRB1 MBL2 TLR2
10
Show member pathways
11.89 CD40LG HLA-DRB1 TLR2 TNF
11
Show member pathways
11.68 FCN2 FCN3 MASP2 MBL2
12 11.63 HLA-DRB1 TLR2 TNF
13
Show member pathways
11.53 CD40LG IL2 TNF
14
Show member pathways
11.41 CD40LG IL2 TNF
15 11.33 HLA-DRB1 MASP2 MBL2
16 11.23 CD40LG TLR2 TNF
17
Show member pathways
11.18 FCN1 FCN2 FCN3 MASP2 MBL2
18 11.11 CD40LG IL2
19 11.02 HLA-DRB1 IL2
20 10.81 HLA-DRB1 IL2 TNF

GO Terms for Rheumatic Fever

Cellular components related to Rheumatic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CD40LG HP IL2 MASP2 MBL2 TNF
2 extracellular region GO:0005576 9.61 CD40LG FCN1 FCN2 FCN3 HP IL2
3 cell surface GO:0009986 9.55 CD40LG HLA-DRB1 MBL2 TLR2 TNF
4 blood microparticle GO:0072562 9.5 FCN2 FCN3 HP
5 collagen trimer GO:0005581 8.92 FCN1 FCN2 FCN3 MBL2

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.88 FCN1 FCN2 FCN3 HP MASP2 MBL2
2 immune response GO:0006955 9.83 CD40LG HLA-DRB1 IL2 TLR2 TNF
3 innate immune response GO:0045087 9.8 FCN1 FCN2 FCN3 MASP2 MBL2 TLR2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 CD40LG TLR2 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.67 FCN2 MBL2 TLR2 TNF
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.58 TLR2 TNF
7 positive regulation of interleukin-8 production GO:0032757 9.58 TLR2 TNF
8 positive regulation of interleukin-12 production GO:0032735 9.57 CD40LG TLR2
9 positive regulation of interleukin-10 production GO:0032733 9.56 CD40LG TLR2
10 immune system process GO:0002376 9.56 FCN1 FCN2 FCN3 HLA-DRB1 IL2 MASP2
11 positive regulation of chemokine production GO:0032722 9.55 TLR2 TNF
12 complement activation GO:0006956 9.55 FCN1 FCN2 FCN3 MASP2 MBL2
13 negative regulation of viral entry into host cell GO:0046597 9.52 FCN1 FCN3
14 negative regulation of growth of symbiont in host GO:0044130 9.51 MBL2 TNF
15 positive regulation of interleukin-8 secretion GO:2000484 9.49 FCN1 TLR2
16 opsonization GO:0008228 9.48 FCN2 MBL2
17 regulation of immunoglobulin secretion GO:0051023 9.46 CD40LG TNF
18 recognition of apoptotic cell GO:0043654 9.43 FCN1 FCN2 FCN3
19 complement activation, lectin pathway GO:0001867 9.02 FCN1 FCN2 FCN3 MASP2 MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.37 CD40LG TNF
2 carbohydrate binding GO:0030246 9.35 FCN1 FCN2 FCN3 IL2 MBL2
3 calcium-dependent protein binding GO:0048306 9.33 FCN2 MASP2 MBL2
4 signaling pattern recognition receptor activity GO:0008329 9.26 FCN1 TLR2
5 serine-type endopeptidase activity GO:0004252 9.1 FCN1 FCN2 FCN3 HP MASP2 MBL2
6 protein binding GO:0005515 10.1 CD40LG FCN1 FCN2 FCN3 HLA-DRB1 HP

Sources for Rheumatic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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