MCID: RHM035
MIFTS: 41

Rheumatic Fever-Related Antigen

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Rheumatic Fever-Related Antigen

MalaCards integrated aliases for Rheumatic Fever-Related Antigen:

Name: Rheumatic Fever-Related Antigen 57
Rheumatic Fever 59 73
Acute Rheumatic Fever 59

Characteristics:

Orphanet epidemiological data:

59
rheumatic fever
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Canada),1-5/10000 (Spain),>1/1000 (Australia),1-5/10000 (India),>1/1000 (Mexico),1-9/100000 (Latin America),1-9/100000 (New Zealand); Age of onset: Childhood; Age of death: adult;

OMIM:

57
Inheritance:
? autosomal recessive


Classifications:



External Ids:

OMIM 57 268240
Orphanet 59 ORPHA3099
ICD10 via Orphanet 34 I00 I01.0 I01.1 more
MESH via Orphanet 45 D012213
UMLS via Orphanet 74 C0035436
MedGen 42 C1849383
SNOMED-CT via HPO 69 386661006 50177009
UMLS 73 C0035436

Summaries for Rheumatic Fever-Related Antigen

MalaCards based summary : Rheumatic Fever-Related Antigen, also known as rheumatic fever, is related to toxic shock syndrome and rheumatic fever. An important gene associated with Rheumatic Fever-Related Antigen is MYOM2 (Myomesin 2). Affiliated tissues include heart, skin and b cells, and related phenotypes are fever and gait disturbance

Description from OMIM: 268240

Related Diseases for Rheumatic Fever-Related Antigen

Diseases related to Rheumatic Fever-Related Antigen via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 toxic shock syndrome 29.2 MYOM2 TLR2
2 rheumatic fever 12.9
3 sydenham chorea 12.0
4 rheumatic myocarditis 11.7
5 acute articular rheumatism 11.5
6 aortic valve disease 2 11.4
7 rheumatic encephalitis 11.2
8 chorea, childhood-onset, with psychomotor retardation 11.1
9 heart disease 10.9
10 rheumatic heart disease 10.9
11 arthritis 10.6
12 glomerulonephritis 10.6
13 endocarditis 10.5
14 pharyngitis 10.5
15 kawasaki disease 10.5
16 atrial standstill 1 10.3
17 tonsillitis 10.3
18 reactive arthritis 10.3
19 acute poststreptococcal glomerulonephritis 10.3
20 scarlet fever 10.3
21 atrioventricular block 10.2
22 systemic lupus erythematosus 10.2
23 rheumatoid arthritis 10.2
24 mitral valve insufficiency 10.2
25 subacute bacterial endocarditis 10.2
26 lupus erythematosus 10.2
27 infective endocarditis 10.1
28 antiphospholipid syndrome 10.1
29 purpura 10.1
30 septic arthritis 10.1
31 pulmonary edema 10.1
32 pyoderma 10.1
33 pneumonia 10.1
34 myocarditis 10.1
35 collagen disease 10.1
36 streptococcal group a invasive disease 10.1
37 orthostatic intolerance 10.0
38 choreatic disease 10.0
39 pericarditis 10.0
40 syncope 10.0
41 autoimmune disease 9.9
42 wolff-parkinson-white syndrome 9.9
43 atrioventricular dissociation 9.9
44 australia antigen 9.9
45 hypoascorbemia 9.9
46 penicillin allergy 9.9
47 osteomyelitis 9.9
48 fiedler's myocarditis 9.9
49 gastric ulcer 9.9
50 cardiac tamponade 9.9

Graphical network of the top 20 diseases related to Rheumatic Fever-Related Antigen:



Diseases related to Rheumatic Fever-Related Antigen

Symptoms & Phenotypes for Rheumatic Fever-Related Antigen

Symptoms via clinical synopsis from OMIM:

57
Immunology:
predisposition to rheumatic fever

Lab:
increased frequency of b cells with 883 antigen


Clinical features from OMIM:

268240

Human phenotypes related to Rheumatic Fever-Related Antigen:

59 32 (show all 37)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 59 32 Frequent (79-30%) HP:0001945
2 gait disturbance 59 Occasional (29-5%)
3 nausea and vomiting 59 Very frequent (99-80%)
4 constipation 59 Occasional (29-5%)
5 chorea 59 Frequent (79-30%)
6 respiratory insufficiency 59 Occasional (29-5%)
7 neurological speech impairment 59 Occasional (29-5%)
8 behavioral abnormality 59 Occasional (29-5%)
9 arthritis 59 Very frequent (99-80%)
10 fatigue 59 Frequent (79-30%)
11 subcutaneous nodule 59 Very frequent (99-80%)
12 arthralgia 59 Frequent (79-30%)
13 arrhythmia 59 Frequent (79-30%)
14 pallor 59 Frequent (79-30%)
15 abdominal pain 59 Frequent (79-30%)
16 aplasia/hypoplasia of the abdominal wall musculature 59 Occasional (29-5%)
17 sinusitis 59 Frequent (79-30%)
18 abnormality of the heart valves 59 Occasional (29-5%)
19 abnormality of the aortic valve 59 Frequent (79-30%)
20 abnormality of the pleura 59 Occasional (29-5%)
21 nephrotic syndrome 59 Occasional (29-5%)
22 anorexia 59 Very frequent (99-80%)
23 migraine 59 Occasional (29-5%)
24 abnormality of the immune system 32 HP:0002715
25 chest pain 59 Frequent (79-30%)
26 erythema 59 Occasional (29-5%)
27 epistaxis 59 Occasional (29-5%)
28 abnormality of the mitral valve 59 Frequent (79-30%)
29 pericarditis 59 Occasional (29-5%)
30 fasciculations 59 Occasional (29-5%)
31 dyslexia 59 Occasional (29-5%)
32 dysgraphia 59 Occasional (29-5%)
33 macule 59 Very frequent (99-80%)
34 myocarditis 59 Frequent (79-30%)
35 hemiballismus 59 Occasional (29-5%)
36 endocarditis 59 Frequent (79-30%)
37 recurrent pharyngitis 59 Frequent (79-30%)

Drugs & Therapeutics for Rheumatic Fever-Related Antigen

Search Clinical Trials , NIH Clinical Center for Rheumatic Fever-Related Antigen

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Rheumatic Fever-Related Antigen

Anatomical Context for Rheumatic Fever-Related Antigen

MalaCards organs/tissues related to Rheumatic Fever-Related Antigen:

41
Heart, Skin, B Cells, Tonsil, Testes, T Cells, Bone

Publications for Rheumatic Fever-Related Antigen

Articles related to Rheumatic Fever-Related Antigen:

(show top 50) (show all 1457)
# Title Authors Year
1
The role of social determinants of health in the risk and prevention of group A streptococcal infection, acute rheumatic fever and rheumatic heart disease: A systematic review. ( 29897915 )
2018
2
MBL2 gene polymorphism rs1800450 and rheumatic fever with and without rheumatic heart disease: an Egyptian pilot study. ( 29653582 )
2018
3
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
4
Acute Rheumatic Fever, Kawasaki Disease or Alternative Diagnoses? A Call for the General Paediatrician. ( 29870101 )
2018
5
Acute rheumatic fever presenting as complete heart block: report of an adolescent case and review of literature. ( 29440244 )
2018
6
Predictive performance of six mortality risk scores and the development of a novel model in a prospective cohort of patients undergoing valve surgery secondary to rheumatic fever. ( 29979692 )
2018
7
Rheumatic fever - new diagnostic criteria. ( 29686441 )
2018
8
Acute Rheumatic Fever: Revised Diagnostic Criteria. ( 29851920 )
2018
9
Epidemiologic Impact of the New Guidelines for the Diagnosis of Acute Rheumatic Fever. ( 29605389 )
2018
10
Acute Rheumatic Fever: Revised Diagnostic Criteria. ( 29851921 )
2018
11
Aboriginal children and penicillin injections for rheumatic fever: how much of a problem is injection pain? ( 29168304 )
2018
12
The Jones Criteria for the Diagnosis of Acute Rheumatic Fever: Updated but Not Abandoned. ( 29709345 )
2018
13
Estimating the likely true changes in rheumatic fever incidence using two data sources. ( 29208066 )
2018
14
Delayed Diagnosis of Acute Rheumatic Fever in a Patient with Multiple Emergency Department Visits. ( 29974004 )
2018
15
Transition to adult care for Aboriginal children with rheumatic fever: a review informed by a focussed ethnography in northern Australia. ( 29310752 )
2018
16
Rheumatic fever: The rebound phenomenon returns. ( 29411467 )
2018
17
Syncope due to complete atrioventricular block and treatment with a transient pacemaker in acute rheumatic fever. ( 30459521 )
2018
18
Concurrent diagnosis of infective endocarditis and acute rheumatic fever: A case report. ( 30279878 )
2018
19
Acute rheumatic fever presenting with severe endocarditis involving four valves, and ventricular tachycardia - ERRATUM. ( 30334506 )
2018
20
Acute rheumatic fever presenting with severe endocarditis involving four valves, and ventricular tachycardia. ( 30160648 )
2018
21
A Clear-cut Case of Acute Rheumatic Fever After Group G Streptococcal Pharyngitis in New Zealand. ( 29533349 )
2018
22
Acute rheumatic fever. ( 30025809 )
2018
23
Primary prevention of rheumatic fever in the 21st century: evaluation of a national programme. ( 30060070 )
2018
24
"That Heart Sickness": Young Aboriginal People's Understanding of Rheumatic Fever. ( 30067382 )
2018
25
Wolff-Parkinson-White syndrome presenting with steroid-induced bradycardia in a patient with acute rheumatic fever. ( 30070198 )
2018
26
Paediatric acute rheumatic fever in developed countries: Neglected or negligible disease? Results from an observational study in Lombardy (Italy). ( 30094276 )
2018
27
Streptococcal Serology in Acute Rheumatic Fever Patients: Findings from Two High-income, High Burden Settings. ( 30256313 )
2018
28
An old disease re-emerging: acute rheumatic fever. ( 30287435 )
2018
29
Complete heart block in young adult with acute rheumatic fever. ( 30350813 )
2018
30
Poor long-term adherence to secondary penicillin prophylaxis in children with history of rheumatic fever. ( 30415945 )
2018
31
Rheumatic fever: update on the Jones criteria according to the American Heart Association review - 2015. ( 28743364 )
2017
32
Emm type distribution of group A streptococcus isolates from the throat swabs of children living in areas with a high (Northland and Gisborne) or low (Palmerston North) incidence of acute rheumatic fever. ( 28796768 )
2017
33
Using preceding hospital admissions to identify children at risk of developing acute rheumatic fever. ( 29168244 )
2017
34
Can We Eliminate Rheumatic Fever and Premature Deaths From RHD? ( 28552220 )
2017
35
Enablers and barriers to secondary prophylaxis for rheumatic fever among MA8ori aged 14-21 in New Zealand: a framework method study. ( 29149897 )
2017
36
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. ( 29269013 )
2017
37
Acute rheumatic fever: clinical profile in children in western Ukraine. ( 28616087 )
2017
38
Acute rheumatic fever and isolated myocarditis. ( 28560960 )
2017
39
Rheumatic fever as an indicator of child health. ( 28796766 )
2017
40
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
41
MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study. ( 28576308 )
2017
42
Prescribing for people with acute rheumatic fever. ( 28507400 )
2017
43
WhA8nau perceptions and experiences of acute rheumatic fever diagnosis for MA8ori in Northland, New Zealand. ( 29121626 )
2017
44
Clinical management and patient persistence with antibiotic course in suspected group A streptococcal pharyngitis for primary prevention of rheumatic fever: the perspective from a New Zealand emergency department. ( 28617790 )
2017
45
Atrial fibrillation 50 years after acute rheumatic fever as the first manifestation of rheumatic mitral stenosis. ( 28405095 )
2017
46
Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers. ( 29067978 )
2017
47
Rheumatic Fever Presenting as Recurrent Pericarditis and Cardiac Tamponade. ( 28720034 )
2017
48
Acute rheumatic fever and exposure to poor housing conditions in New Zealand: A descriptive study. ( 28052445 )
2017
49
Erratum in: Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 28584595 )
2017
50
Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa. ( 28430286 )
2017

Variations for Rheumatic Fever-Related Antigen

Expression for Rheumatic Fever-Related Antigen

Search GEO for disease gene expression data for Rheumatic Fever-Related Antigen.

Pathways for Rheumatic Fever-Related Antigen

GO Terms for Rheumatic Fever-Related Antigen

Sources for Rheumatic Fever-Related Antigen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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