MCID: RHM035
MIFTS: 37

Rheumatic Fever-Related Antigen

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Rheumatic Fever-Related Antigen

MalaCards integrated aliases for Rheumatic Fever-Related Antigen:

Name: Rheumatic Fever-Related Antigen 57
Rheumatic Fever 58 70
Acute Rheumatic Fever 58

Characteristics:

Orphanet epidemiological data:

58
rheumatic fever
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Canada),1-5/10000 (Spain),>1/1000 (Australia),1-5/10000 (India),>1/1000 (Mexico),1-9/100000 (Latin America),1-9/100000 (New Zealand); Age of onset: Childhood; Age of death: adult;

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
? autosomal recessive


HPO:

31
rheumatic fever-related antigen:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


External Ids:

OMIM® 57 268240
MESH via Orphanet 45 D012213
ICD10 via Orphanet 33 I00 I01.0 I01.1 more
UMLS via Orphanet 71 C0035436
Orphanet 58 ORPHA3099
MedGen 41 C1849383
SNOMED-CT via HPO 68 258211005 386661006 50177009
UMLS 70 C0035436

Summaries for Rheumatic Fever-Related Antigen

MalaCards based summary : Rheumatic Fever-Related Antigen, also known as rheumatic fever, is related to rheumatic fever and sydenham chorea. The drugs Etanercept and Tofacitinib have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotypes are fever and nausea and vomiting

More information from OMIM: 268240

Related Diseases for Rheumatic Fever-Related Antigen

Diseases related to Rheumatic Fever-Related Antigen via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever 12.1
2 sydenham chorea 11.5
3 rheumatic myocarditis 11.3
4 choreatic disease 11.3
5 rheumatic heart disease 11.2
6 acute articular rheumatism 11.2
7 rheumatic encephalitis 11.2
8 aortic valve disease 2 11.1
9 jaccoud's syndrome 11.1
10 wissler-fanconi syndrome 11.0
11 chorea, childhood-onset, with psychomotor retardation 10.9
12 heart disease 10.9
13 pharyngitis 10.9
14 glomerulonephritis 10.8
15 endocarditis 10.7
16 mitral valve insufficiency 10.7
17 enthesopathy 10.6
18 infective endocarditis 10.6
19 mitral valve stenosis 10.5
20 kawasaki disease 10.5
21 tonsillitis 10.5
22 aortic valve insufficiency 10.5
23 reactive arthritis 10.5
24 streptococcal group a invasive disease 10.5
25 acute poststreptococcal glomerulonephritis 10.5
26 atrioventricular block 10.5
27 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.5
28 scarlet fever 10.5
29 heart valve disease 10.4
30 myocarditis 10.4
31 pericarditis 10.4
32 exanthem 10.4
33 pyoderma 10.4
34 septic arthritis 10.4
35 autoimmune disease 10.4
36 purpura 10.4
37 congestive heart failure 10.4
38 allergic disease 10.3
39 juvenile rheumatoid arthritis 10.3
40 obsessive-compulsive disorder 10.3
41 arthritis 10.3
42 collagen disease 10.3
43 orthostatic intolerance 10.3
44 hemopericardium 10.3
45 pericardial effusion 10.3
46 lupus erythematosus 10.3
47 systemic lupus erythematosus 10.3
48 syncope 10.3
49 inflammatory spondylopathy 10.3
50 spondylitis 10.3

Graphical network of the top 20 diseases related to Rheumatic Fever-Related Antigen:



Diseases related to Rheumatic Fever-Related Antigen

Symptoms & Phenotypes for Rheumatic Fever-Related Antigen

Human phenotypes related to Rheumatic Fever-Related Antigen:

58 31 (show all 37)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 Frequent (79-30%) HP:0001945
2 nausea and vomiting 58 Very frequent (99-80%)
3 neurological speech impairment 58 Occasional (29-5%)
4 gait disturbance 58 Occasional (29-5%)
5 constipation 58 Occasional (29-5%)
6 chorea 58 Frequent (79-30%)
7 respiratory insufficiency 58 Occasional (29-5%)
8 behavioral abnormality 58 Occasional (29-5%)
9 arthritis 58 Very frequent (99-80%)
10 fatigue 58 Frequent (79-30%)
11 sinusitis 58 Frequent (79-30%)
12 abnormal heart valve morphology 58 Occasional (29-5%)
13 aplasia/hypoplasia of the abdominal wall musculature 58 Occasional (29-5%)
14 abnormal aortic valve morphology 58 Frequent (79-30%)
15 abnormality of the pleura 58 Occasional (29-5%)
16 pallor 58 Frequent (79-30%)
17 nephrotic syndrome 58 Occasional (29-5%)
18 subcutaneous nodule 58 Very frequent (99-80%)
19 abdominal pain 58 Frequent (79-30%)
20 anorexia 58 Very frequent (99-80%)
21 arthralgia 58 Frequent (79-30%)
22 arrhythmia 58 Frequent (79-30%)
23 abnormality of the immune system 31 HP:0002715
24 dysgraphia 58 Occasional (29-5%)
25 epistaxis 58 Occasional (29-5%)
26 abnormal mitral valve morphology 58 Frequent (79-30%)
27 pericarditis 58 Occasional (29-5%)
28 migraine 58 Occasional (29-5%)
29 fasciculations 58 Occasional (29-5%)
30 dyslexia 58 Occasional (29-5%)
31 erythema 58 Occasional (29-5%)
32 macule 58 Very frequent (99-80%)
33 myocarditis 58 Frequent (79-30%)
34 hemiballismus 58 Occasional (29-5%)
35 endocarditis 58 Frequent (79-30%)
36 chest pain 58 Frequent (79-30%)
37 recurrent pharyngitis 58 Frequent (79-30%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Immunology:
predisposition to rheumatic fever

Lab:
increased frequency of b cells with 883 antigen

Clinical features from OMIM®:

268240 (Updated 05-Apr-2021)

Drugs & Therapeutics for Rheumatic Fever-Related Antigen

Drugs for Rheumatic Fever-Related Antigen (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etanercept Approved, Investigational Phase 4 185243-69-0
2
Tofacitinib Approved, Investigational Phase 4 477600-75-2
3 Immunologic Factors Phase 4
4 Immunosuppressive Agents Phase 4
5 Gastrointestinal Agents Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Analgesics, Non-Narcotic Phase 4
8 Analgesics Phase 4
9 Antirheumatic Agents Phase 4
10 Protein Kinase Inhibitors Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12
Abatacept Approved 332348-12-6 10237
13
rituximab Approved 174722-31-7 10201696
14
Prednisolone acetate Approved, Vet_approved 52-21-1
15
Methylprednisolone Approved, Vet_approved 83-43-2 6741
16
Prednisolone Approved, Vet_approved 50-24-8 5755
17
Prednisolone phosphate Approved, Vet_approved 302-25-0
18
Methylprednisolone hemisuccinate Approved 2921-57-5
19
Allopurinol Approved 315-30-0 2094
20
Febuxostat Approved 144060-53-7 134018
21
Prednisolone hemisuccinate Experimental 2920-86-7
22
Uric acid Investigational 69-93-2 1175
23 Bacteriocins
24 Immunoglobulins
25 Antibodies
26 Antistreptolysin
27 Neuroprotective Agents
28 Methylprednisolone Acetate
29 Hormone Antagonists
30 Antiemetics
31 Protective Agents
32 Hormones
33 Janus Kinase Inhibitors
34 penicillins
35 glucocorticoids

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Capability of Tofacitinib or Etanercept to Accelerate Clinical Relevant Tapering of Non-steroidal Anti-inflammatory Drugs (NSAID) and Treat-to-target Guided De-escalation of Corticosteroids in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Previous csDMARD Therapy (AcceleRAte) Recruiting NCT04485325 Phase 4 Tofacitinib
2 DOES ETANERCEPT INFLUENCE TWEAK MODULATION OF INFLAMMATION DURING INFLAMMATORY RHEUMATISMS (PSORIATIC ARTHRITIS AND RHEUMATOID ARTHRITIS)? Completed NCT02164214 Phase 3 etanercept Treatment
3 Phase II Study of Physiotherapy in Rheumatoid Arthritis: Randomized Single Blind Wait-list Controlled Trial Unknown status NCT02020668 Phase 2
4 A Block-randomized, Double-blind, Placebo-controlled, Single-dose Escalating, Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
5 Phase I Clinical Trial for Assessment of Safety and Immunogenicity of a Synthetic Vaccine Against Streptococcus Pyogenes in Healthy Volunteers Withdrawn NCT03998592 Phase 1
6 Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Adherence to Penicillin Secondary Prophylaxis Unknown status NCT03183180
7 Efficacy of Streptococcus Salivarius BLIS (Bacteriocin-like Inhibitory Substance) K12 as Preventive Measure for Rheumatic Children. Unknown status NCT02407106
8 Fertility Study of Women With Chronic Inflammatory Rheumatism Unknown status NCT03452735
9 Transversal Study of Correlations Between Pain Catastrophizing Scale (PCS) and RAPID3 Score According to Ten Categories of Conditions Seen in an Outpatient Rheumatology Clinic Unknown status NCT03306784
10 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
11 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
12 Clinical Audit on the Managment of Rheumatic Fever in Assiut University Children Hospital Completed NCT03281863
13 East Arnhem Healthy Skin Project: A Regional Collaboration to Reduce Scabies, Skin Sores and Associated Chronic Diseases, Including Rheumatic Fever and Renal Disease, Among Australian Aboriginal Communities Completed NCT00884728
14 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
15 Digitally Assisted High-intensity Interval Training in Inflammatory Rheumatic Disease Patients: Treatment by Man or Machine? Completed NCT04649528
16 Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases Completed NCT03216616
17 Selection of Patients With Chronic Inflammatory Rheumatism Requiring Management During the COVID-19 Pandemia Through an Innovative Organizational Strategy Completed NCT04806867
18 The Genetic Basis of Acquired Heart Disease in Africa Completed NCT02124109
19 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases and Their Family: a Crossover Trial Completed NCT01511341
20 Morbimortality of Covid-19 in Patients With Chronic Inflammatory Rheumatism Treated With Immunosuppressants Recruiting NCT04426279
21 Cardiovascular Risk and Chronic Inflammatory Rheumatism Recruiting NCT03187444
22 Non-interventional Clinical Trial to Establish a Glucocorticoid-induced Osteoporosis Databank for Patients With Chronic Inflammatory Rheumatic Diseases or Psoriasis and Therapy With Glucocorticoids Recruiting NCT02719314 Glucocorticoid treatment
23 Impact of Association of Individual and Group Therapeutic Education Sessions on the Acquisition of Safety Skills by Patients With Chronic Inflammatory Rheumatism (CIR) Treated With Subcutaneous Biotherapy, Compared to Individual Therapeutic Education Sessions Alone Recruiting NCT03838939
24 Prospective, Non-Interventional, Multicenter, Post-Market Clinical Follow-up Study CoreHip® Recruiting NCT03685110
25 Covid-19 in Patients With Chronic Inflammatory Rheumatism, Auto-immune or Auto-inflammatory Rare and Non-rare Diseases : a Retrospective Multicenter Observational Study Recruiting NCT04353609
26 JAKINIB Study: " 'Observational', Multicentre Trial Collecting Prospective and On-going Clinical and Laboratory Data for Patients Treated With JAK Inhibitors for Inflammatory Rheumatism According to EMA." Recruiting NCT04602091
27 Regulatory B Cells in Inflammatory Rheumatisms, Systemic Auto-immune Diseases in Adults and Biomarkers of Response to Biologic Treatments Recruiting NCT01642706
28 Catastrophism in Chronic Inflammatory Rheumatism Active, not recruiting NCT04174092
29 Assessment of Long Acting Penicillin (LAP) Use in Patients Diagnosed With Rheumatic Fever in Assiut University Children Hospital (AUCH) Not yet recruiting NCT04316897
30 Treat-to-target by Email During Urate-lowering Therapy in Gout Not yet recruiting NCT04733079
31 Assessment of the Psychological Impact of the COVID19 (SARS-CoV-2) Pandemic on Patients With Chronic Inflammatory Rheumatism According to a Management Strategy in the Rheumatology Department of Limoges University Hospital Not yet recruiting NCT04723407
32 PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS Not yet recruiting NCT04664465
33 Study of Leukocyte Populations in Patients With Chronic Inflammatory Not yet recruiting NCT04749875
34 Prospective, Multi-centric, Comparative, Long-term Clinical Follow-Up Study for the Evidence of Safety and Performance Indicators of the Plasmafit® Revision Structan® Hip Endoprosthesis Cup Not yet recruiting NCT04255966
35 Longitudinal Follow-up of Patients With Chronic Inflammatory Rheumatisms (CIRs) Vaccinated Against COVID-19 Compared to Patients Refusing Vaccination Not yet recruiting NCT04832022
36 Mental Health Consequences of COVID19 Infection in the French Rheumatic Musculoskeletal Diseases (RMD) Cohort Not yet recruiting NCT04510467
37 Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected Patients Not yet recruiting NCT04798053

Search NIH Clinical Center for Rheumatic Fever-Related Antigen

Inferred drug relations via UMLS 70 / NDF-RT 51 :


ACETYLSALICYLATE SODIUM
Aspirin
ASPIRIN PWDR
choline salicylate

Genetic Tests for Rheumatic Fever-Related Antigen

Anatomical Context for Rheumatic Fever-Related Antigen

MalaCards organs/tissues related to Rheumatic Fever-Related Antigen:

40
Heart, Skin, Brain, T Cells, B Cells, Cortex, Liver

Publications for Rheumatic Fever-Related Antigen

Articles related to Rheumatic Fever-Related Antigen:

(show top 50) (show all 7104)
# Title Authors PMID Year
1
Presence of the d8/17 B-cell marker in children with rheumatic fever in Israel. 57 61
12030895 2002
2
Rheumatic fever susceptibility in four ascertainments: regressive segregation on a geometric ascertainment pattern. 57 61
2250095 1990
3
Presence of a non-HLA B cell antigen in rheumatic fever patients and their families as defined by a monoclonal antibody. 57 61
2785121 1989
4
Rheumatic fever-associated B cell alloantigens as identified by monoclonal antibodies. 61 57
3876100 1985
5
Association of a B-cell alloantigen with susceptibility to rheumatic fever. 57 61
310969 1979
6
Possible genetic factors in the etiology of rheumatic fever. 61 57
13050610 1953
7
Heredity and rheumatic fever; a study of 462 families ascertained by an affected child and 51 families ascertained by an affected mother. 61 57
13031388 1953
8
RHEUMATIC FEVER AS A FAMILIAL DISEASE. ENVIRONMENT, COMMUNICABILITY AND HEREDITY IN THEIR RELATION TO THE OBSERVED FAMILIAL INCIDENCE OF THE DISEASE. 57 61
16694503 1937
9
Reducing antibiotic prescriptions in children is not associated with higher rate of complications. 61
33145703 2021
10
Myocarditis and intracardiac thrombus due to Henoch-Schönlein purpura: case report and literature review. 61
32789615 2021
11
Association of Maternal Autoimmune Disease With Attention-Deficit/Hyperactivity Disorder in Children. 61
33464287 2021
12
The 2020 Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease. 61
33190309 2021
13
An evidence-based scoring system to diagnose acute rheumatic fever with carditis in children. 61
33667575 2021
14
Adherence rates and risk factors for suboptimal adherence to secondary prophylaxis for rheumatic fever. 61
33340191 2021
15
Different antibiotic treatments for group A streptococcal pharyngitis. 61
33728634 2021
16
Rheumatic heart disease in Indigenous young peoples. 61
33705693 2021
17
Investigating inequities in cardiovascular care and outcomes for Queensland Aboriginal and Torres Strait Islander people: protocol for a hospital-based retrospective cohort data linkage project. 61
33741666 2021
18
Relevance of Rheumatic Valvular Heart Disease in the Aetiology of Heart Failure in Contemporary Times. 61
33765372 2021
19
Evolution of epidemiological characteristics of infective endocarditis in Greece. 61
33711517 2021
20
Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever. 61
33639619 2021
21
[NEW ONSET OF VALVULAR HEART DISEASE ALONG WITH ANCIENT PATHOLOGIC FINDING]. 61
33760410 2021
22
The number and activity of CD3+TCR Vα7.2+CD161+ cells are increased in children with acute rheumatic fever. 61
33631279 2021
23
Acute Congestive Heart Failure in a Young Woman. 61
33644737 2021
24
A case report of isolated rheumatic tricuspid regurgitation and pericarditis. 61
33603640 2021
25
Update on SARS-CoV-2 infection in children. 61
33616026 2021
26
Progress in Research of Asymptomatic Primary Mitral Regurgitation Examination Methods: A Review of Literature. 61
33635239 2021
27
Rheumatic heart disease: A review of the current status of global research activity. 61
33333234 2021
28
Update on Post-Streptococcal Reactive Arthritis: Narrative Review of a Forgotten Disease. 61
33569668 2021
29
Study of the relation between serum levels of long-acting penicillin and the inflammatory markers: C-reactive protein and interleukin-6 in patients with chronic rheumatic heart disease. 61
33638745 2021
30
A comprehensive quality evaluation of Fuzi and its processed product through integration of UPLC-QTOF/MS combined MS/MS-based mass spectral molecular networking with multivariate statistical analysis and HPLC-MS/MS. 61
33039630 2021
31
Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. 61
33179113 2021
32
Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice. 61
32841699 2021
33
Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings. 61
33575142 2021
34
Neurologic complications of rheumatic fever. 61
33632442 2021
35
Acute Rheumatic Fever: Where Do We Stand? An Epidemiological Study in Northern Italy. 61
33718402 2021
36
Rising Ethnic Inequalities in Acute Rheumatic Fever and Rheumatic Heart Disease, New Zealand, 2000-2018. 61
33350929 2021
37
Ficolin-3 in rheumatic fever and rheumatic heart disease. 61
33232720 2021
38
The clinical value of ficolin-3 gene polymorphism in rheumatic heart disease. An Egyptian adolescents study. 61
33499929 2021
39
Genetics, Structure, and Function of Group A Streptococcal Pili. 61
33633705 2021
40
Optical Coherence Tomography Findings in Nodular Anterior Scleritis due to Post-Streptococcal Syndrome. 61
33520137 2021
41
Streptococcus-associated vasculitis: A role for antibiotic therapy? 61
33777696 2021
42
Comparison between 2D and 3D Echocardiography in Efficient Detection of Commissural Calcification in Rheumatic Mitral Stenosis. 61
33397845 2021
43
Echocardiographic Screening Detects Rheumatic Heart Disease and Missed Opportunities in the Treatment of Group A Streptococcal Infections in Australian Torres Strait Islander Children. 61
33432909 2021
44
Heart Disease and Pregnancy: The Need for a Twenty-First Century Approach to Care…. 61
32778509 2021
45
Pacific Fono: a community-based initiative to improve rheumatic fever service delivery for Pacific Peoples in South Auckland. 61
33349328 2020
46
Previous Traditional Medicine Use for Sore Throat among Children Evaluated for Rheumatic Fever in Northern Uganda. 61
33319727 2020
47
[Bertolt Brecht. Did he really have rheumatic fever?] 61
32761253 2020
48
Haploinsufficiency of A20 (HA20): updates on the genetics, phenotype, pathogenesis and treatment. 61
31587140 2020
49
The use of cardiac valve procedures for rheumatic heart disease in Australia; a cross-sectional study 2002-2017. 61
33299561 2020
50
A novel aspect may explain the mechanisms of pathogenicity of rheumatic fever, a multifactorial, autoimmune, infectious and inflammatory disorder which "licks the joints and bites the heart": A working hypothesis. 61
33254529 2020

Variations for Rheumatic Fever-Related Antigen

Expression for Rheumatic Fever-Related Antigen

Search GEO for disease gene expression data for Rheumatic Fever-Related Antigen.

Pathways for Rheumatic Fever-Related Antigen

GO Terms for Rheumatic Fever-Related Antigen

Sources for Rheumatic Fever-Related Antigen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....