RHD
MCID: RHM028
MIFTS: 56

Rheumatic Heart Disease (RHD)

Categories: Cardiovascular diseases

Aliases & Classifications for Rheumatic Heart Disease

MalaCards integrated aliases for Rheumatic Heart Disease:

Name: Rheumatic Heart Disease 12 54 6 15 17 70
Rheumatic Congestive Heart Failure 12 15
Congestive Rheumatic Heart Failure 12 70
Rheumatic Heart Failure 12
Rheumatic Carditis 12
Rhd 48

Classifications:



External Ids:

Disease Ontology 12 DOID:0050827 DOID:14172
ICD9CM 34 398.91
SNOMED-CT 67 82523003
UMLS 70 C0035439 C0155582

Summaries for Rheumatic Heart Disease

Disease Ontology : 12 A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.

MalaCards based summary : Rheumatic Heart Disease, also known as rheumatic congestive heart failure, is related to typhoid fever and heart valve disease. An important gene associated with Rheumatic Heart Disease is MIR328 (MicroRNA 328), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ramipril and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and brain, and related phenotypes are hematopoietic system and immune system

Related Diseases for Rheumatic Heart Disease

Diseases related to Rheumatic Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 836)
# Related Disease Score Top Affiliating Genes
1 typhoid fever 31.6 TNF IL6 IL1B HLA-DRB1 HLA-DQB1
2 heart valve disease 31.5 TGFB1 MYOM2 IL1B CNMD ACE
3 mitral valve disease 31.4 IL4 IL10 ACE
4 rheumatic fever 31.1 TNF TLR2 MYOM2 MBL2 IL6 IL10
5 pharyngitis 31.1 TNF MYOM2 IL6 IL1B HLA-DRB1
6 congestive heart failure 31.1 TNF IL6 IL1B ACE
7 endocarditis 31.1 VCAM1 TNF TLR2 IL6 IL10
8 infective endocarditis 31.0 TNF TLR2 IL6 CNMD
9 heart disease 30.9 VCAM1 TNF TLR2 TGFB1 MYOM2 IL6
10 toxoplasmosis 30.9 TNF TLR2 TGFB1 IL6 IL4 IL1B
11 pulmonary edema 30.7 TNF IL1B IL10 ACE
12 endomyocardial fibrosis 30.7 TNF IL4 IL10
13 pericarditis 30.7 TNF IL6 IL1B ACE
14 cardiogenic shock 30.5 TNF IL6
15 pyoderma 30.5 TNF MYOM2 IL1B
16 purpura 30.5 TNF IL6 IL4 IL10 ACE
17 vasculitis 30.4 VCAM1 TNF MBL2 IL6
18 malaria 30.4 VCAM1 TNF TLR2 TGFB1 MBL2 IL6
19 disseminated intravascular coagulation 30.4 TNF IL6 IL10
20 tuberculous meningitis 30.4 TNF TLR2 TGFB1
21 glomerulonephritis 30.4 VCAM1 TGFB1 MBL2 IL1B ACE
22 syphilis 30.4 TNF IL6 HLA-DRB1 ACE
23 appendicitis 30.2 TNF IL6 IL1B IL10
24 brucellosis 30.2 TNF TGFB1 IL6 IL4 IL10
25 tonsillitis 30.2 TNF TLR2 IL6 IL4 IL1B IL10
26 aspiration pneumonia 30.2 TNF IL6 ACE
27 cerebrovascular disease 30.2 VCAM1 TNF IL6 ACE
28 calcinosis 30.2 TNF HLA-DRB1 HLA-DQB1 HLA-DQA1
29 arteries, anomalies of 30.2 VCAM1 TNF IL6 IL1B ACE
30 aortitis 30.2 TNF IL6 IL1B
31 covid-19 30.2 IL6 IL4 IL1B ACE
32 amyloidosis 30.1 TNF MYOM2 IL6 IL1B
33 iritis 30.1 TNF IL6 IL10 ACE
34 myocarditis 30.1 VCAM1 TNF IL6 IL4 IL1B IL10
35 limb ischemia 30.1 TNF IL6 ACE
36 polyarteritis nodosa 30.1 VCAM1 IL6 HLA-DRB1
37 familial mediterranean fever 30.1 TNF TLR2 IL6 IL1B IL10
38 spondylitis 30.0 TNF IL6 IL1B IL10
39 arteriosclerosis 30.0 VCAM1 IL6 IL4 IL10 ACE
40 portal hypertension 30.0 TNF TGFB1 ACE
41 hemorrhagic disease 30.0 TNF MYOM2 IL6 IL4 IL1B IL10
42 erysipelas 30.0 TNF MYOM2 IL6 IL1B
43 cysticercosis 30.0 IL6 IL4 IL1B IL10
44 acquired immunodeficiency syndrome 30.0 VCAM1 TNF IL6 IL1B IL10
45 peritonitis 30.0 TNF TLR2 IL6 IL4 IL1B IL10
46 speech and communication disorders 30.0 TNF IL6 IL1B ACE
47 lupus erythematosus 30.0 TNF IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1 FCN3
48 diamond-blackfan anemia 1 29.9 TNF IL6 IL4 IL1B IL10
49 sickle cell anemia 29.9 VCAM1 TNF IL6 IL1B IL10 HLA-DRB1
50 placenta disease 29.9 TNF IL6 IL1B

Comorbidity relations with Rheumatic Heart Disease via Phenotypic Disease Network (PDN): (show all 19)


Active Peptic Ulcer Disease Acute Cystitis
Aortic Valve Disease 1 Aortic Valve Disease 2
Aortic Valve Insufficiency Bronchitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intracranial Embolism
Mitral Valve Disease Mitral Valve Stenosis
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Rheumatic Myocarditis Rheumatic Pulmonary Valve Disease
Sinoatrial Node Disease Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Rheumatic Heart Disease:



Diseases related to Rheumatic Heart Disease

Symptoms & Phenotypes for Rheumatic Heart Disease

MGI Mouse Phenotypes related to Rheumatic Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 ACE CNMD HLA-DQA1 HLA-DQB1 IL10 IL1B
2 immune system MP:0005387 9.97 ACE CNMD HLA-DQA1 HLA-DQB1 IL10 IL1B
3 liver/biliary system MP:0005370 9.56 ACE HLA-DQB1 IL10 IL4 IL6 TGFB1
4 neoplasm MP:0002006 9.17 ACE IL10 IL1B IL6 TGFB1 TLR2

Drugs & Therapeutics for Rheumatic Heart Disease

Drugs for Rheumatic Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 82)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ramipril Approved Phase 3 87333-19-5 5362129
2
Thrombin Approved, Investigational Phase 3
3
Protein C Approved Phase 3
4
Warfarin Approved Phase 3 81-81-2 54678486 6691
5
Rivaroxaban Approved Phase 3 366789-02-8
6
Vitamin K1 Approved, Investigational Phase 3 84-80-0 5284607
7
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
8
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
9 Menaquinone Investigational Phase 3 1182-68-9
10 Natriuretic Peptide, Brain Phase 2, Phase 3
11 Angiotensin-Converting Enzyme Inhibitors Phase 3
12 Antihypertensive Agents Phase 3
13 Antidotes Phase 3
14 Vitamin K 1 Phase 3
15 protein S Phase 3
16 Nutrients Phase 3
17 Micronutrients Phase 3
18 Trace Elements Phase 3
19 Antifibrinolytic Agents Phase 3
20 Coagulants Phase 3
21 Hemostatics Phase 3
22 Vitamin K Phase 3
23 Anticoagulants Phase 3
24 Serine Proteinase Inhibitors Phase 3
25 Vitamins Phase 3
26 Antithrombin III Phase 3
27 naphthoquinone Phase 3
28
protease inhibitors Phase 3
29 Factor Xa Inhibitors Phase 3
30 HIV Protease Inhibitors Phase 3
31 Antithrombins Phase 3
32 Analgesics, Non-Narcotic Phase 3
33 Fibrinolytic Agents Phase 3
34 Analgesics Phase 3
35 Antirheumatic Agents Phase 3
36 Cyclooxygenase Inhibitors Phase 3
37 Anti-Inflammatory Agents Phase 3
38 Antipyretics Phase 3
39 Anti-Inflammatory Agents, Non-Steroidal Phase 3
40 Platelet Aggregation Inhibitors Phase 3
41
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
42
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
43
Procaine Approved, Investigational, Vet_approved Phase 2 59-46-1 4914
44
Penicillin G Approved, Vet_approved Phase 2 61-33-6 5904
45 Pharmaceutical Solutions Phase 2
46 glutamine Phase 2
47 Respiratory System Agents Phase 2
48 Protective Agents Phase 2
49 Expectorants Phase 2
50 Antioxidants Phase 2

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Pocket-Echocardiography Integrated Mobile Health Device Assessments in Modern Structural Heart Disease Clinics Completed NCT02881398 Phase 2, Phase 3
2 The Effect of Ramipril in Suppressing Gene Expression of Fibrosis in Cardiac Mitral Stenosis in Patients With Rheumatic Heart Disease Recruiting NCT03991910 Phase 3 Placebos;Ramipril 5Mg Oral Capsule
3 RIvoraxaban Safety and Efficacy in Patients With Mitral Stenosis Recruiting NCT03926156 Phase 3 Rivaroxaban;Warfarin
4 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies Active, not recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
5 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
6 Intravenous Supplementation of Glutamine Preoperatively for Cardiac Function and Recovery Improvement in Adult Accepting Cardiosurgery: A Randomized, Double-Blinded, Placebo-Controlled Trial Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
7 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement. Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
8 The GOAL (GwokO Adunu pa Lutino) Trial: Determining the Impact of Penicillin on Latent Rheumatic Heart Disease: A Randomized Controlled Trial in Uganda Active, not recruiting NCT03346525 Phase 2 intramuscular benzathine penicillin G (BPG) prophylaxis
9 Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia Completed NCT00482573 Phase 1
10 Assessment of Rheumatic Heart Disease Patients With Chronic Severe Mitral Regurge by Speckle Tracking Echocardiography for Proper Timing of Surgical Operation. Unknown status NCT03156972
11 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
12 Right Ventricular Function After Mitral Valve Replacement in Rheumatic Heart Disease Patients With Pulmonary Hypertension: Short Term Follow up Unknown status NCT03549052
13 Bipolar Radiofrequency Ablation Plus Endocardial Ablation Using Argon Beam Coagulator for Atrial Fibrillation Treatment in Patients With Rheumatic Heart Disease Unknown status NCT02424110
14 Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery Completed NCT01175681
15 Outcome of MC3 Ring Annuloplasty for Moderate and Severe Functional Tricuspid Regurgitation Associated With Rheumatic Mitral Valve Disease Completed NCT04078867
16 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524
17 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
18 Prospective Cohort Study Compares Effect of Corrected and Uncorrected Rheumatic Heart Valve of Pregnant Women on Maternal and Fetal Outcomes Completed NCT03029117
19 The Cardiac Protective Effect of Simvastatin on Cardiac Surgery: a Double Blind, Randomised Clinical Trial Completed NCT01178710 Simvastatin
20 A Population-Based Study of Prevalence of Rheumatic Heart Disease and Cardiovascular Outcomes Among Schoolchildren in Nepal Completed NCT01550068
21 Genome-wide Association Study of Susceptibility to Rheumatic Heart Disease in Fiji and New Caledonia Completed NCT02188862
22 The Genetic Basis of Acquired Heart Disease in Africa Completed NCT02124109
23 Prevalence of Rheumatic Heart Disease in Zambian Schoolchildren: an Echocardiographic Screening Study Involving Task-shifting to General Radiographers Completed NCT02661763
24 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
25 Study of the Prevalence of Rheumatic Heart Disease in Leon, Nicaragua Completed NCT00307112
26 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 1: The Prevalence of Rheumatic Heart Disease, Pyoderma and Scabies in School Children in Fiji Completed NCT00284843
27 Different Modalities for Evaluation of Fetal Cardiac Function in Pregnant Women With Rheumatic Heart Disease (RHD) Patients Completed NCT03095937
28 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration in Patients With Rheumatic Heart Disease Completed NCT01426776
29 Prevalence of Rheumatic Heart Disease in Pregnancy Among a Population of Antenatal Patients at a Tertiary Care Institution in Western Kenya Completed NCT03411993
30 Pilot, Randomized,Single Blind Trial of Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion Completed NCT02474108
31 Multicenter Results of Mitral Valve Surgery in Patients With Rheumatic Heart Disease Recruiting NCT04780607
32 Next Generation Sequencing Approach to the Study of Rheumatic Heart Disease Recruiting NCT02118818
33 The Clinical Influence of Developing a Sustainable Cardiac Surgery Service to Reduce the Burden of Rheumatic Heart Disease in Sub-Saharan Africa Recruiting NCT04556188
34 Role of Statins In Slowing Rheumatic Heart Disease (RHD) Progression: A Feasibility Study For A Randomized Controlled Trial Not yet recruiting NCT04575857 Atorvastatin;Placebo

Search NIH Clinical Center for Rheumatic Heart Disease

Genetic Tests for Rheumatic Heart Disease

Anatomical Context for Rheumatic Heart Disease

MalaCards organs/tissues related to Rheumatic Heart Disease:

40
Heart, T Cells, Brain, Endothelial, Skin, Cortex, Thyroid

Publications for Rheumatic Heart Disease

Articles related to Rheumatic Heart Disease:

(show top 50) (show all 4560)
# Title Authors PMID Year
1
MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation. 61 47
21098446 2010
2
Synergistic effect of mitral expression of tissue inhibitor of metalloproteinase-2 with hypertension on the occurrence of mitral chordae tendinae rupture. 61 54
19727008 2009
3
High-producing MBL2 genotypes increase the risk of acute and chronic carditis in patients with history of rheumatic fever. 61 54
18602696 2008
4
The association between mannose-binding lectin gene polymorphism and rheumatic heart disease. 61 54
17174748 2006
5
Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. 54 61
16980969 2006
6
Significantly increased levels of mannose-binding lectin (MBL) in rheumatic heart disease: a beneficial role for MBL deficiency. 54 61
15544631 2004
7
The inter-rater reliability and individual reviewer performance of the 2012 world heart federation guidelines for the echocardiographic diagnosis of latent rheumatic heart disease. 61
33186665 2021
8
How reproducible is the diagnosis of borderline rheumatic heart disease? 61
33359287 2021
9
Contemporary trends in surgical rheumatic valve disease in a Caribbean nation. 61
33309762 2021
10
The 2020 Australian guideline for prevention, diagnosis and management of acute rheumatic fever and rheumatic heart disease. 61
33190309 2021
11
An evidence-based scoring system to diagnose acute rheumatic fever with carditis in children. 61
33667575 2021
12
Adherence rates and risk factors for suboptimal adherence to secondary prophylaxis for rheumatic fever. 61
33340191 2021
13
Impact of COVID-19 on pregnant women with Rheumatic heart disease or Peripartum cardiomyopathy. 61
33487485 2021
14
Cardiac point of care ultrasound in resource limited settings to manage children with congenital and acquired heart disease. 61
33682650 2021
15
Rheumatic heart disease in Indigenous young peoples. 61
33705693 2021
16
Investigating inequities in cardiovascular care and outcomes for Queensland Aboriginal and Torres Strait Islander people: protocol for a hospital-based retrospective cohort data linkage project. 61
33741666 2021
17
Closing the gap on rheumatic heart disease. 61
33160963 2021
18
Re-expansion Pulmonary Edema-A Rare Entity: A Thin Line between Pulmonary and Cardiac Decompensation. 61
33790520 2021
19
Mitral valve repair in children with rheumatic heart disease. 61
33642715 2021
20
Mitral valve surgery for rheumatic heart disease: replace, repair, retrain? 61
33394710 2021
21
Cardiac Surgery and Small Island States: A Bridge Too Far? 61
32721454 2021
22
Neglected cardiovascular diseases and their significance in the Global North. 61
33506326 2021
23
Managing asymptomatic severe rheumatic mitral stenosis in pregnancy: a case report. 61
33693306 2021
24
Atrial Fibrillation in Valvular Heart Disease. 61
33516389 2021
25
An unusual case of spontaneous obstructive thrombus complicating rheumatic mitral stenosis. 61
33767492 2021
26
A new over-the-wire percutaneous mitral balloon valvuloplasty technique. 61
33788393 2021
27
Multivalvular destruction as the primary presentation of aggressive infective endocarditis with subaortic valve membrane. 61
33679959 2021
28
The Commando procedure: Can it be a preventive option from reoperation in pediatric patients? 61
33428270 2021
29
Rheumatic heart disease: A review of the current status of global research activity. 61
33333234 2021
30
Study of the relation between serum levels of long-acting penicillin and the inflammatory markers: C-reactive protein and interleukin-6 in patients with chronic rheumatic heart disease. 61
33638745 2021
31
Submitral aneurysm of varied aetiologies: a case series. 61
33738423 2021
32
Clinical outcomes following surgical mitral valve repair or replacement in patients with rheumatic heart disease: a meta-analysis. 61
33708831 2021
33
Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study. 61
33607192 2021
34
The number and activity of CD3+TCR Vα7.2+CD161+ cells are increased in children with acute rheumatic fever. 61
33631279 2021
35
Pregnancy in women with cardiac disease: a one-year retrospective review of management and maternal and neonatal outcomes in a tertiary hospital in Johannesburg, South Africa. 61
33559676 2021
36
Recovery of atrial contractile function after cut-and-sew maze for long-standing persistent valvular atrial fibrillation. 61
32920067 2021
37
Cytokine gene functional polymorphisms and phenotypic expression as predictors of evolution from latent to clinical rheumatic heart disease. 61
33341346 2021
38
Novel handheld ultrasound technology to enhance non-expert screening for rheumatic heart disease in the Republic of Palau: A descriptive study. 61
33624369 2021
39
Cardiac Anesthesiologist and Global Capacity Building to Tackle Rheumatic Heart Disease. 61
33637422 2021
40
Prevalence of Rheumatic Heart Disease and Other Cardiac Conditions in Low-Risk Pregnancies in Kenya: A Prospective Echocardiography Screening Study. 61
33598390 2021
41
Cardiovascular imaging modalities in the diagnosis and management of rheumatic heart disease. 61
32980432 2021
42
Examining the Ugandan health system's readiness to deliver rheumatic heart disease-related services. 61
33591974 2021
43
Agreement between three-dimensional planimetry and mitral navigation method in the assessment of mitral valve area in rheumatic severe mitral stenosis. 61
32452754 2021
44
Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease. 61
33179113 2021
45
Non-coding RNAs: The key detectors and regulators in cardiovascular disease. 61
33164830 2021
46
Health Disparities among Australia's Remote-Dwelling Aboriginal People: A Report from 2020. 61
33241298 2021
47
Neurologic complications of rheumatic fever. 61
33632442 2021
48
Acute Rheumatic Fever: A Review of Essential Cutaneous and Histological Findings. 61
33575142 2021
49
Rising Ethnic Inequalities in Acute Rheumatic Fever and Rheumatic Heart Disease, New Zealand, 2000-2018. 61
33350929 2021
50
Ficolin-3 in rheumatic fever and rheumatic heart disease. 61
33232720 2021

Variations for Rheumatic Heart Disease

ClinVar genetic disease variations for Rheumatic Heart Disease:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 FCN3 NM_003665.4(FCN3):c.658+250C>A SNV risk factor 992481 GRCh37: 1:27696837-27696837
GRCh38: 1:27370346-27370346
2 FCN3 NM_003665.4(FCN3):c.393+178T>A SNV Uncertain significance 992482 GRCh37: 1:27699449-27699449
GRCh38: 1:27372958-27372958

Expression for Rheumatic Heart Disease

Search GEO for disease gene expression data for Rheumatic Heart Disease.

Pathways for Rheumatic Heart Disease

Pathways related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 VCAM1 TNF TLR2 TGFB1 MBL2 IL6
2
Show member pathways
13.4 VCAM1 TNF TGFB1 IL6 IL4 IL1B
3
Show member pathways
13.28 VCAM1 TNF TLR2 TGFB1 MBL2 IL6
4
Show member pathways
13.26 TNF TLR2 IL4 IL1B HLA-DRB1 HLA-DQB1
5
Show member pathways
12.9 TNF TLR2 IL6 IL1B HLA-DRB1 HLA-DQB1
6
Show member pathways
12.89 TNF TGFB1 IL6 IL4 IL1B IL10
7 12.88 TNF TLR2 IL6 IL1B HLA-DRB1 HLA-DQB1
8
Show member pathways
12.75 TNF TLR2 TGFB1 IL6 IL1B
9
Show member pathways
12.72 TNF IL4 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
10
Show member pathways
12.66 TNF TLR2 TGFB1 IL6 IL4 IL1B
11 12.65 VCAM1 TNF TLR2 IL4 IL1B IL10
12
Show member pathways
12.6 TNF TLR2 TGFB1 IL6 IL4 IL1B
13 12.43 TNF TGFB1 IL6 HLA-DRB1 HLA-DQB1 HLA-DQA1
14
Show member pathways
12.42 TNF TLR2 IL6 IL4 IL1B
15
Show member pathways
12.36 TNF IL6 IL4 IL1B
16
Show member pathways
12.36 TNF TGFB1 IL6 IL4 IL1B IL10
17
Show member pathways
12.29 TNF TGFB1 IL6 ACE
18
Show member pathways
12.28 TNF TLR2 IL6 IL4 IL1B
19
Show member pathways
12.26 TNF IL6 IL1B IL10
20
Show member pathways
12.25 TNF TLR2 TGFB1 IL4 IL1B IL10
21 12.24 TNF TLR2 TGFB1 IL6
22 12.23 TLR2 MBL2 HLA-DRB1 HLA-DQB1 HLA-DQA1
23 12.22 TNF IL6 IL1B IL10
24 12.18 VCAM1 HLA-DRB1 HLA-DQB1 HLA-DQA1
25 12.15 TNF IL6 IL1B IL10
26 12.11 TNF TGFB1 IL6 IL4 IL1B
27 12.06 TNF IL6 IL4 IL10
28 12.06 VCAM1 TNF TGFB1 IL6 IL4 IL1B
29 12.06 TNF TLR2 TGFB1 IL6 IL1B IL10
30 12.04 VCAM1 TNF IL6 IL1B
31 12.02 VCAM1 TNF TGFB1 IL6 IL1B
32 12.01 TNF TLR2 TGFB1 IL6 IL1B IL10
33 11.98 MBL2 IL10 HLA-DRB1 HLA-DQB1 HLA-DQA1
34 11.97 TNF IL6 IL4 IL1B HLA-DRB1 HLA-DQB1
35
Show member pathways
11.94 TLR2 TGFB1 IL6 IL4 IL1B
36 11.89 TNF IL4 IL1B IL10
37 11.86 TNF IL6 IL1B IL10
38
Show member pathways
11.84 HLA-DRB1 HLA-DQB1 HLA-DQA1
39
Show member pathways
11.84 TNF TLR2 TGFB1 IL6 IL1B IL10
40 11.83 TNF TGFB1 IL6 IL1B IL10
41
Show member pathways
11.77 VCAM1 TNF IL6 IL1B
42 11.77 VCAM1 TNF TLR2 TGFB1 IL6 IL4
43 11.76 HLA-DRB1 HLA-DQB1 HLA-DQA1
44 11.76 TNF TGFB1 IL6 IL4 IL1B
45 11.71 TNF TLR2 IL6 IL1B
46 11.64 TNF IL6 IL4 IL1B IL10
47 11.58 TNF TLR2 IL1B
48 11.57 TNF TGFB1 IL1B
49 11.54 TNF IL6 IL1B
50 11.53 TNF TLR2 TGFB1 IL6 IL1B HLA-DRB1

GO Terms for Rheumatic Heart Disease

Cellular components related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 TNF TGFB1 MBL2 IL6 IL4 IL1B
2 lysosome GO:0005764 9.85 IL1B HLA-DRB1 HLA-DQB1 HLA-DQA1 ACE
3 cell surface GO:0009986 9.85 VCAM1 TNF TLR2 TGFB1 MBL2 HLA-DRB1
4 endocytic vesicle membrane GO:0030666 9.65 HLA-DRB1 HLA-DQB1 HLA-DQA1
5 ER to Golgi transport vesicle membrane GO:0012507 9.61 HLA-DRB1 HLA-DQB1 HLA-DQA1
6 transport vesicle membrane GO:0030658 9.58 HLA-DRB1 HLA-DQB1 HLA-DQA1
7 clathrin-coated endocytic vesicle membrane GO:0030669 9.5 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 extracellular space GO:0005615 9.44 VCAM1 TNF TGFB1 MIR328 MBL2 IL6
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.43 HLA-DRB1 HLA-DQB1 HLA-DQA1
10 MHC class II protein complex GO:0042613 9.13 HLA-DRB1 HLA-DQB1 HLA-DQA1

Biological processes related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.14 TLR2 MBL2 HLA-DRB1 HLA-DQB1 HLA-DQA1 FCN3
2 negative regulation of cell proliferation GO:0008285 10.11 TLR2 TGFB1 IL6 IL1B IL10
3 positive regulation of transcription, DNA-templated GO:0045893 10.11 TNF TGFB1 IL6 IL4 IL1B IL10
4 inflammatory response GO:0006954 10.1 TNF TLR2 TGFB1 IL6 IL1B
5 positive regulation of gene expression GO:0010628 10.09 TNF TLR2 TGFB1 IL6 IL4 IL1B
6 positive regulation of protein phosphorylation GO:0001934 10.01 TNF TGFB1 IL1B HLA-DRB1
7 response to lipopolysaccharide GO:0032496 9.99 VCAM1 TLR2 IL1B IL10
8 cellular response to lipopolysaccharide GO:0071222 9.99 TNF IL6 IL1B IL10
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 TNF IL6 IL1B IL10
10 B cell differentiation GO:0030183 9.9 VCAM1 IL4 IL10
11 regulation of insulin secretion GO:0050796 9.9 TNF IL6 IL1B
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.9 TNF IL6 IL4
13 cellular response to organic cyclic compound GO:0071407 9.89 TNF TGFB1 IL1B
14 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TNF TLR2 IL1B
15 response to glucocorticoid GO:0051384 9.89 TNF IL6 IL10
16 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 TNF TLR2 TGFB1 IL6 IL1B
17 negative regulation of fat cell differentiation GO:0045599 9.87 TNF TGFB1 IL6
18 positive regulation of interleukin-6 production GO:0032755 9.86 TNF TLR2 IL6 IL1B
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.85 TGFB1 IL6 IL1B
20 antigen processing and presentation GO:0019882 9.85 HLA-DRB1 HLA-DQB1 HLA-DQA1
21 negative regulation of T cell proliferation GO:0042130 9.85 TGFB1 IL10 HLA-DRB1
22 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.84 TNF TGFB1 IL10
23 protein kinase B signaling GO:0043491 9.84 TNF TGFB1 IL1B
24 interferon-gamma-mediated signaling pathway GO:0060333 9.84 VCAM1 HLA-DRB1 HLA-DQB1 HLA-DQA1
25 positive regulation of chemokine production GO:0032722 9.83 TNF TLR2 IL6
26 positive regulation of interleukin-10 production GO:0032733 9.83 TLR2 IL6 IL4
27 negative regulation of mitotic cell cycle GO:0045930 9.83 TNF TGFB1 IL10
28 liver regeneration GO:0097421 9.81 TGFB1 IL6 IL10
29 positive regulation of T cell proliferation GO:0042102 9.81 VCAM1 IL6 IL4 IL1B
30 positive regulation of JAK-STAT cascade GO:0046427 9.8 TNF IL6 IL10
31 microglial cell activation GO:0001774 9.8 TNF TLR2 IL4
32 positive regulation of vascular endothelial growth factor production GO:0010575 9.78 TGFB1 IL6 IL1B
33 positive regulation of interleukin-8 production GO:0032757 9.76 TNF TLR2 IL6 IL1B
34 negative regulation of neurogenesis GO:0050768 9.75 TNF IL6 IL1B
35 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.73 TNF TGFB1
36 positive regulation of MHC class II biosynthetic process GO:0045348 9.73 IL4 IL10
37 response to molecule of bacterial origin GO:0002237 9.73 TLR2 IL10
38 regulation of establishment of endothelial barrier GO:1903140 9.73 TNF IL1B
39 neutrophil mediated immunity GO:0002446 9.73 IL6 ACE
40 negative regulation of lipid storage GO:0010888 9.72 TNF IL6
41 positive regulation of glial cell proliferation GO:0060252 9.72 TNF IL6 IL1B
42 defense response to Gram-positive bacterium GO:0050830 9.72 TNF TLR2 MBL2 IL6 FCN2
43 endothelial cell apoptotic process GO:0072577 9.71 TNF IL10
44 recognition of apoptotic cell GO:0043654 9.71 FCN3 FCN2
45 opsonization GO:0008228 9.7 MBL2 FCN2
46 negative regulation of cytokine production involved in immune response GO:0002719 9.7 TNF IL10
47 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.7 HLA-DRB1 HLA-DQB1
48 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.7 TNF IL1B IL10
49 type 2 immune response GO:0042092 9.68 IL4 IL10
50 positive regulation of fever generation GO:0031622 9.68 TNF IL1B

Molecular functions related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 TGFB1 IL6 IL4 IL10
2 peptide antigen binding GO:0042605 9.33 HLA-DRB1 HLA-DQB1 HLA-DQA1
3 MHC class II receptor activity GO:0032395 9.13 HLA-DRB1 HLA-DQB1 HLA-DQA1
4 cytokine activity GO:0005125 9.1 TNF TGFB1 IL6 IL4 IL1B IL10

Sources for Rheumatic Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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