MCID: RHM028
MIFTS: 51

Rheumatic Heart Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Rheumatic Heart Disease

MalaCards integrated aliases for Rheumatic Heart Disease:

Name: Rheumatic Heart Disease 12 55 15 73
Congestive Rheumatic Heart Failure 12 73
Rheumatic Congestive Heart Failure 12
Rheumatic Heart Failure 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050827 DOID:14172
ICD10 33 I09.81 I09.8
ICD9CM 35 398.91
SNOMED-CT 68 82523003

Summaries for Rheumatic Heart Disease

Disease Ontology : 12 A heart valve disease that is characterized by repeated inflammation with fibrinous repair. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.It is caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage.

MalaCards based summary : Rheumatic Heart Disease, also known as congestive rheumatic heart failure, is related to mitral valve disease and rheumatic fever. An important gene associated with Rheumatic Heart Disease is MIR328 (MicroRNA 328
It was first verified the upregulation of miR-328 in the atrial tissue from atrial fibrillation (AF) patients with rheumatic heart disease. miR-328 contributes to the adverse atrial electric remodeling in AF through targeting L-type Ca2+ channel genes. The study therefore uncovered a novel molecular mechanism for AF and indicated miR-328 as a potential therapeutic target for AF. ), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Warfarin and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Rheumatic Heart Disease

Diseases related to Rheumatic Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 mitral valve disease 31.7 ACE IL10 IL4
2 rheumatic fever 31.2 HLA-DRB1 MASP2 MBL2 MYOM2 TNF
3 rheumatic disease 30.8 HLA-DRB1 IL10 TNF VCAM1
4 endomyocardial fibrosis 30.7 IL10 IL4 TNF
5 endocarditis 30.2 IL10 IL6 TNF VCAM1
6 reactive arthritis 30.1 IL10 IL6 TNF
7 tonsillitis 29.9 IL4 IL6 TNF
8 arthritis 29.6 HLA-DRB1 IL10 IL6 TNF
9 pneumonia 29.6 IL10 IL6 MBL2 TNF
10 brucellosis 29.6 IL10 IL4 IL6 TNF
11 arteries, anomalies of 29.4 ACE IL6 TNF VCAM1
12 aphthous stomatitis 28.1 HLA-A IL10 IL4 IL6 TNF
13 autoimmune disease 28.0 HLA-DQA1 HLA-DRB1 IL10 IL4 IL6 MBL2
14 diabetes mellitus 27.7 ACE HLA-A HLA-DQA1 HLA-DRB1 IL6 TNF
15 systemic lupus erythematosus 27.3 HLA-DQA1 HLA-DRB1 IL10 IL4 IL6 MBL2
16 rheumatic myocarditis 11.4
17 rheumatic fever-related antigen 11.1
18 punctate inner choroidopathy 10.9 IL10 TNF
19 heart disease 10.9
20 focal epithelial hyperplasia 10.9 HLA-DQA1 HLA-DRB1
21 multifocal choroiditis 10.9 IL10 TNF
22 inflammatory bowel disease 25, autosomal recessive 10.8 IL10 TGFB1
23 subacute cutaneous lupus erythematosus 10.8 ACE TNF
24 transient hypogammaglobulinemia 10.8 IL10 TNF
25 skin sarcoidosis 10.8 ACE TNF
26 idiopathic inflammatory myopathy 10.8 HLA-DQA1 HLA-DRB1
27 granulomatous dermatitis 10.8 ACE TNF
28 autoimmune pancreatitis 10.8 HLA-DRB1 TNF
29 recurrent respiratory papillomatosis 10.8 HLA-DQA1 HLA-DRB1
30 chronic beryllium disease 10.8 HLA-DRB1 TNF
31 familial vesicoureteral reflux 10.8 ACE TGFB1
32 hyperlucent lung 10.7 IL10 IL4
33 microscopic polyangiitis 10.7 HLA-DRB1 IL10 TNF
34 choroiditis 10.7 IL10 TNF
35 immunoglobulin a deficiency 1 10.7 IL10 IL4
36 scabies 10.7 IL10 MBL2
37 panuveitis 10.7 HLA-DRB1 IL10 TNF
38 scorpion envenomation 10.7 IL6 TNF
39 severe hemophilia a 10.7 HLA-DRB1 IL10 TNF
40 vulvar vestibulitis syndrome 10.7 MBL2 TNF
41 juvenile myasthenia gravis 10.7 HLA-DRB1 IL10 TGFB1
42 adult dermatomyositis 10.7 MBL2 TNF
43 sympathetic ophthalmia 10.6 HLA-DQA1 HLA-DRB1 TNF
44 leukomalacia 10.6 IL6 TNF
45 mitral valve stenosis 10.6
46 beryllium disease 10.6 HLA-DRB1 TGFB1 TNF
47 angioimmunoblastic lymphadenopathy with dysproteinemia 10.6 IL6 TNF
48 helicobacter pylori infection 10.6 HLA-DRB1 IL10 TNF
49 idiopathic achalasia 10.6 IL10 TNF
50 lichen sclerosus 10.6 HLA-DRB1 TNF

Comorbidity relations with Rheumatic Heart Disease via Phenotypic Disease Network (PDN): (show all 21)


Active Peptic Ulcer Disease Acute Cystitis
Aortic Valve Disease 1 Aortic Valve Disease 2
Aortic Valve Insufficiency Bronchitis
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intracranial Embolism Ischemic Heart Disease
Mitral Valve Disease Mitral Valve Stenosis
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Rheumatic Myocarditis Rheumatic Pulmonary Valve Disease
Sinoatrial Node Disease Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Rheumatic Heart Disease:



Diseases related to Rheumatic Heart Disease

Symptoms & Phenotypes for Rheumatic Heart Disease

MGI Mouse Phenotypes related to Rheumatic Heart Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.81 HLA-DQA1 IL10 IL4 IL6 MBL2 TGFB1
2 immune system MP:0005387 9.65 HLA-DQA1 IL10 IL4 IL6 MASP2 MBL2
3 liver/biliary system MP:0005370 9.1 ACE IL10 IL4 IL6 TGFB1 TNF

Drugs & Therapeutics for Rheumatic Heart Disease

Drugs for Rheumatic Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 3 81-81-2 6691 54678486
2
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
3
Rivaroxaban Approved Phase 3 366789-02-8
4
Dalteparin Approved Phase 3 9005-49-6
5
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
6
Thrombin Approved, Investigational Phase 3
7
Tinzaparin Approved Phase 3 9005-49-6, 9041-08-1 25244225
8
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
9
Phytonadione Approved, Investigational, Nutraceutical Phase 3 84-80-0 4812 5284607
10
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
11 Natriuretic Peptide, Brain Phase 2, Phase 3
12 Anticoagulants Phase 3
13 Peripheral Nervous System Agents Phase 3,Phase 1
14 Analgesics Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Antifibrinolytic Agents Phase 3
17 Anti-Inflammatory Agents Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 3
19 Antipyretics Phase 3
20 Antirheumatic Agents Phase 3
21 Antithrombin III Phase 3
22 Antithrombins Phase 3
23 Coagulants Phase 3
24 Cyclooxygenase Inhibitors Phase 3
25 Factor Xa Inhibitors Phase 3
26 Fibrinolytic Agents Phase 3
27 Hemostatics Phase 3
28 HIV Protease Inhibitors Phase 3
29 Micronutrients Phase 3
30 Platelet Aggregation Inhibitors Phase 3
31
protease inhibitors Phase 3
32 Serine Proteinase Inhibitors Phase 3
33 Trace Elements Phase 3
34 Vitamins Phase 3
35 calcium heparin Phase 3
36 Heparin, Low-Molecular-Weight Phase 3
37 Menaquinone Nutraceutical Phase 3
38 naphthoquinone Nutraceutical Phase 3
39 Vitamin K Nutraceutical Phase 3
40
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
41
Penicillin G Approved, Vet_approved Phase 2 61-33-6 5904
42
Procaine Approved, Investigational, Vet_approved Phase 2 59-46-1 4914
43 Antidotes Phase 2
44 Anti-Infective Agents Phase 2
45 Antioxidants Phase 2
46 Antiviral Agents Phase 2
47 Expectorants Phase 2
48 N-monoacetylcystine Phase 2
49 Protective Agents Phase 2
50 Respiratory System Agents Phase 2,Phase 1

Interventional clinical trials:

(show all 39)
# Name Status NCT ID Phase Drugs
1 Mobile Health in Structural Heart Disease Completed NCT02881398 Phase 2, Phase 3
2 Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) Completed NCT00000517 Phase 3 warfarin
3 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority Not yet recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
4 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
5 Early Versus Late Resumption of Anticoagulation in Patients With Both High Thrombosis Risk and Major HEmoRrhage Terminated NCT02091479 Phase 3 UFH Early group;UFH Late group
6 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
7 Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
8 Determining the Impact of Penicillin in Latent RHD: The GOAL Trial Not yet recruiting NCT03346525 Phase 2 intramuscular benzathine penicillin G (BPG) prophylaxis
9 Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease Completed NCT00482573 Phase 1
10 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Recruiting NCT03361163 Phase 1
11 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
12 Rheumatic Heart Disease Prevalence in Leon, Nicaragua Unknown status NCT00307112
13 Bipolar Radiofrequency Ablation Plus Argon Beam Coagulator Ablation for Atrial Fibrillation Unknown status NCT02424110 Not Applicable
14 Ring Versus Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524 Not Applicable
15 Mitochondrial Apoptotic Pathway Induced by Myocardial Ischemia-Reperfusion Injury in Human Unknown status NCT02430116 Not Applicable
16 Clinical Research to Explore Manifestations of Heart Failure Using Infrared Thermal Imaging Technology Unknown status NCT02672618
17 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
18 Rheumatic Heart Disease Study in Lusaka Completed NCT02661763
19 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
20 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524 Not Applicable
21 Prevalence of RHD, Pyoderma and Scabies in Children in Fiji Completed NCT00284843
22 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration Completed NCT01426776 Not Applicable
23 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
24 Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes Completed NCT03029117
25 Effect of Simvastatin on Cardiac Function Completed NCT01178710 Not Applicable Simvastatin
26 Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement Completed NCT02474108 Not Applicable
27 Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery Completed NCT01175681 Not Applicable
28 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
29 Gulf Acute Heart Failure Registry Completed NCT01467973
30 RhEumatiC Heart diseAse Genetics Recruiting NCT02118818
31 Rheumatic Heart Disease School Project Recruiting NCT01550068
32 Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge Recruiting NCT03156972 Not Applicable
33 Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease (RHD) Patients Recruiting NCT03095937
34 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109
35 Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD Recruiting NCT02516800
36 Study of the Prognosis of Infectious Endocarditis (EPEI): Prospective and Retrospective Follow-up of a Cohort of Patients Hospitalized for Infectious Endocarditis Recruiting NCT03211975
37 Right Ventricular Echo Assessment in Mitral Valve Replacement Not yet recruiting NCT03549052
38 Prevalence of Rheumatic Heart Disease Among Pregnant Women in Kenya Not yet recruiting NCT03411993
39 Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis Not yet recruiting NCT03183180

Search NIH Clinical Center for Rheumatic Heart Disease

Genetic Tests for Rheumatic Heart Disease

Anatomical Context for Rheumatic Heart Disease

MalaCards organs/tissues related to Rheumatic Heart Disease:

41
Heart, Brain, T Cells, Endothelial, B Cells, Tonsil, Skin

Publications for Rheumatic Heart Disease

Articles related to Rheumatic Heart Disease:

(show top 50) (show all 321)
# Title Authors Year
1
The role of social determinants of health in the risk and prevention of group A streptococcal infection, acute rheumatic fever and rheumatic heart disease: A systematic review. ( 29897915 )
2018
2
Outcomes for patients with rheumatic heart disease after cardiac surgery followed at rural district hospitals in Rwanda. ( 29678896 )
2018
3
Global Burden of Rheumatic Heart Disease. ( 29303541 )
2018
4
MBL2 gene polymorphism rs1800450 and rheumatic fever with and without rheumatic heart disease: an Egyptian pilot study. ( 29653582 )
2018
5
The association of plasma high-sensitivity C-reactive protein level with rheumatic heart disease: The possible role of inflammation. ( 29961448 )
2018
6
Mitral stenosis due to rheumatic heart disease - A rare cause of massive hemoptysis. ( 29977754 )
2018
7
Global Burden of Rheumatic Heart Disease. ( 29303543 )
2018
8
Association Between the Interferon Gamma 874 T/A Polymorphism and the Severity of Valvular Damage in Patients with Rheumatic Heart Disease. ( 29332266 )
2018
9
Task sharing to improve the prevention, diagnosis and management of rheumatic heart disease: a systematic review protocol. ( 29444786 )
2018
10
Influence of cytokine gene polymorphism on the risk of rheumatic heart disease - A meta-analysis. ( 29317215 )
2018
11
Prevention and control of rheumatic heart disease: Overcoming core challenges in resource-poor environments. ( 29440834 )
2018
12
Trends in Deaths from Rheumatic Heart Disease in the Eastern Mediterranean Region: Burden and Challenges. ( 29848951 )
2018
13
Global Burden of Rheumatic Heart Disease. ( 29298147 )
2018
14
Quadruple valve replacement in a patient with severe rheumatic heart disease. ( 29674478 )
2018
15
Prevalence of rheumatic heart disease in Zambian school children. ( 29969998 )
2018
16
Global Burden of Rheumatic Heart Disease. ( 29303542 )
2018
17
Respirophasic desaturation in multivalvar rheumatic heart disease. ( 29909737 )
2018
18
Efficacy of Statin Therapy Related to Baseline Renal Function in Patients with Rheumatic Heart Disease Undergoing Cardiac Surgery. ( 29850539 )
2018
19
Global Burden of Rheumatic Heart Disease. ( 29303544 )
2018
20
Immune System Activation in Rheumatic Heart Disease. ( 29950255 )
2018
21
Lessons learned in the development of sustained release penicillin drug delivery systems for the prophylactic treatment of rheumatic heart disease (RHD). ( 29404981 )
2018
22
Comparison Between Different Strategies of Rheumatic Heart Disease Echocardiographic Screening in Brazil: Data From the PROVAR (Rheumatic Valve Disease Screening Program) Study. ( 29444774 )
2018
23
Rheumatic heart disease patient event: Cape Town hosts 4th Annual Listen to My Heart Rheumatic Heart Disease for patients at the South African Heart Association meeting in 2017. ( 29762706 )
2018
24
Standard echocardiography versus handheld echocardiography for the detection of subclinical rheumatic heart disease: protocol for a systematic review. ( 29440164 )
2018
25
Echocardiographic screening for rheumatic heart disease in 4 515 Sudanese school children: marked disparity between two communities. ( 29750231 )
2018
26
Global Burden of Rheumatic Heart Disease. ( 29298146 )
2018
27
Valvular Heart Disease in a Young Israeli Ethiopian Immigrant Population From the Gondar Region With Implications for Rheumatic Heart Disease. ( 29868538 )
2018
28
Global Burden of Rheumatic Heart Disease. ( 29320141 )
2018
29
How to design non-essential amino acid-based diet for rheumatic heart disease patients. ( 29671619 )
2018
30
Impact of regionalisation of a national rheumatic heart disease registry: the Ugandan experience. ( 29422951 )
2018
31
Modest leucine supplement for prevention of rheumatic heart disease. ( 29808755 )
2018
32
Rheumatic Heart Disease Prophylaxis in Older Patients: A Register-Based Audit of Adherence to Guidelines. ( 29942824 )
2018
33
Rheumatic Heart Disease of the Mitral Valve: Is There Such Thing as an Ideal Operation? ( 29857975 )
2018
34
A programme to increase appropriate usage of benzathine penicillin for management of streptococcal pharyngitis and rheumatic heart disease in Zambia. ( 28906539 )
2017
35
Thrombocytopenia as a Preoperative Risk Assessment Tool in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Surgery. ( 29203580 )
2017
36
A rapid echocardiographic screening protocol for rheumatic heart disease in Samoa: a high prevalence of advanced disease. ( 28857729 )
2017
37
An Ineffective Differential Diagnosis of Infective Endocarditis and Rheumatic Heart Disease after Streptococcal Skin and Soft Tissue Infection. ( 28794364 )
2017
38
Hypermethylation of brain natriuretic peptide gene is associated with the risk of rheumatic heart disease. ( 27920275 )
2017
39
Group G streptococcus induces an autoimmune IL-17A/IFN-I^ mediated carditis in the Lewis rat model of Rheumatic Heart Disease. ( 29236994 )
2017
40
Rheumatic heart disease in paediatric critical care retrieval. ( 28070958 )
2017
41
Serum glial cell line-derived neurotrophic factor levels and postoperative cognitive dysfunction after surgery for rheumatic heart disease. ( 28918204 )
2017
42
Rheumatic Heart Disease: The Unfinished Global Agenda. ( 27886787 )
2017
43
A focussed single-view hand-held echocardiography protocol for the detection of rheumatic heart disease. ( 28889812 )
2017
44
Cerebral Microbleeds Do Not Predict Hemorrhagic Transformation in Acute Ischemic Stroke Patients with Atrial Fibrillation and/or Rheumatic Heart Disease. ( 28294063 )
2017
45
Epidemiology of pharyngitis as reported by Zambian school children and their families: implications for demand-side interventions to prevent rheumatic heart disease. ( 28683722 )
2017
46
Rheumatic Heart Disease - An Iceberg in Tropical Waters. ( 28834468 )
2017
47
Serum uric acid as a simple risk factor in patients with rheumatic heart disease undergoing valve replacement surgery. ( 28735063 )
2017
48
Screening for rheumatic heart disease: is a paradigm shift required? ( 28864463 )
2017
49
Rheumatic heart disease in a developing country: Incidence and trend (Monastir; Tunisia: 2000-2013). ( 27883972 )
2017
50
Rheumatic heart disease in pregnancy: a report of 2 cases. ( 29721129 )
2017

Variations for Rheumatic Heart Disease

Expression for Rheumatic Heart Disease

Search GEO for disease gene expression data for Rheumatic Heart Disease.

Pathways for Rheumatic Heart Disease

Pathways related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 HLA-A HLA-DQA1 HLA-DRB1 IL10 IL4 IL6
2
Show member pathways
13.29 HLA-A HLA-DQA1 HLA-DRB1 IL10 IL4 IL6
3
Show member pathways
12.97 ACE IL4 IL6 TGFB1 VCAM1
4
Show member pathways
12.97 ACE IL10 IL6 MBL2 TGFB1 TNF
5
Show member pathways
12.78 HLA-A HLA-DQA1 HLA-DRB1 IL10 IL4 IL6
6
Show member pathways
12.73 HLA-A HLA-DQA1 HLA-DRB1 IL4 IL6 TNF
7
Show member pathways
12.6 HLA-A IL10 IL4 IL6 TNF
8
Show member pathways
12.5 HLA-A IL6 TGFB1 TNF
9 12.49 IL10 IL4 TNF VCAM1
10
Show member pathways
12.46 HLA-A HLA-DQA1 HLA-DRB1 VCAM1
11
Show member pathways
12.38 IL10 IL4 IL6 TGFB1 TNF
12 12.26 HLA-A HLA-DQA1 HLA-DRB1 IL10
13
Show member pathways
12.23 IL10 IL6 TGFB1 TNF
14
Show member pathways
12.22 HLA-DQA1 HLA-DRB1 IL10 IL4 IL6 TGFB1
15
Show member pathways
12.21 HLA-DQA1 HLA-DRB1 IL10 IL4 TGFB1 TNF
16
Show member pathways
12.19 ACE IL6 TGFB1 TNF
17 12.13 HLA-A HLA-DQA1 HLA-DRB1 MBL2
18 12.13 HLA-DQA1 HLA-DRB1 IL10 IL6 TGFB1 TNF
19 12.11 HLA-A HLA-DQA1 HLA-DRB1 IL6 TGFB1 TNF
20 12.09 HLA-A HLA-DQA1 HLA-DRB1 VCAM1
21
Show member pathways
12.02 IL10 IL6 TGFB1
22
Show member pathways
12.01 IL10 IL4 IL6 TGFB1
23 12 IL6 TGFB1 VCAM1
24 12 IL4 IL6 TGFB1 TNF
25 11.99 IL6 TGFB1 TNF
26 11.97 IL10 IL4 IL6 TNF
27
Show member pathways
11.91 HLA-A HLA-DRB1 IL4
28 11.89 IL6 TNF VCAM1
29 11.89 IL6 TGFB1 TNF VCAM1
30 11.88 HLA-DQA1 HLA-DRB1 IL4 IL6 TNF
31 11.87 IL10 IL6 TGFB1 TNF
32 11.83 HLA-DQA1 HLA-DRB1 IL6 TGFB1 TNF
33 11.74 IL10 IL4 TNF
34 11.73 IL10 IL6 TGFB1 TNF
35 11.72 IL10 IL6 TNF
36 11.65 IL4 IL6 TGFB1 TNF
37
Show member pathways
11.63 IL6 TNF VCAM1
38 11.53 IL10 IL4 IL6 TNF
39 11.51 HLA-DQA1 HLA-DRB1 IL10 MASP2 MBL2
40 11.49 IL10 IL4 IL6 TGFB1 TNF VCAM1
41 11.41 IL10 IL6 TGFB1 TNF VCAM1
42 11.36 IL10 IL6 TNF VCAM1
43 11.35 IL10 IL6 TNF
44 11.3 IL4 IL6 TNF
45 10.98 IL6 TNF
46 10.89 TNF VCAM1
47 10.83 TGFB1 TNF
48 10.58 HLA-DRB1 IL10 IL4 IL6 TGFB1 TNF

GO Terms for Rheumatic Heart Disease

Cellular components related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.92 ACE IL10 IL4 IL6 MASP2 MBL2
2 external side of plasma membrane GO:0009897 9.67 ACE HLA-DRB1 TNF VCAM1
3 cell surface GO:0009986 9.63 HLA-A HLA-DRB1 MBL2 TGFB1 TNF VCAM1
4 ER to Golgi transport vesicle membrane GO:0012507 9.43 HLA-A HLA-DQA1 HLA-DRB1
5 MHC class II protein complex GO:0042613 9.4 HLA-DQA1 HLA-DRB1
6 extracellular space GO:0005615 9.32 ACE IL10 IL4 IL6 MASP2 MBL2
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-A HLA-DQA1 HLA-DRB1

Biological processes related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.97 IL10 IL6 TGFB1 TNF
2 regulation of signaling receptor activity GO:0010469 9.92 IL10 IL4 IL6 TGFB1 TNF
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL6 TGFB1 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.84 IL10 IL6 TNF
5 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 IL10 IL6 TNF
6 response to organic substance GO:0010033 9.82 IL10 TGFB1 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.81 IL6 MBL2 TNF
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 IL6 TGFB1 TNF
9 B cell differentiation GO:0030183 9.76 IL10 IL4 VCAM1
10 response to glucocorticoid GO:0051384 9.74 IL10 IL6 TNF
11 positive regulation of T cell proliferation GO:0042102 9.73 IL4 IL6 VCAM1
12 negative regulation of fat cell differentiation GO:0045599 9.67 IL6 TGFB1 TNF
13 positive regulation of chemokine production GO:0032722 9.66 IL6 TNF
14 myeloid dendritic cell differentiation GO:0043011 9.66 IL4 TGFB1
15 leukocyte tethering or rolling GO:0050901 9.65 TNF VCAM1
16 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.65 HLA-DQA1 HLA-DRB1
17 antigen processing and presentation GO:0019882 9.65 HLA-A HLA-DQA1 HLA-DRB1
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 IL10 TNF
19 negative regulation of T cell proliferation GO:0042130 9.63 HLA-DRB1 IL10 TGFB1
20 complement activation, lectin pathway GO:0001867 9.62 MASP2 MBL2
21 neutrophil mediated immunity GO:0002446 9.62 ACE IL6
22 negative regulation of lipid storage GO:0010888 9.61 IL6 TNF
23 endothelial cell apoptotic process GO:0072577 9.59 IL10 TNF
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL10 IL4
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 IL10 TNF
26 type 2 immune response GO:0042092 9.54 IL10 IL4
27 negative regulation of mitotic cell cycle GO:0045930 9.54 IL10 TGFB1 TNF
28 regulation of isotype switching GO:0045191 9.51 IL10 IL4
29 interferon-gamma-mediated signaling pathway GO:0060333 9.46 HLA-A HLA-DQA1 HLA-DRB1 VCAM1
30 receptor biosynthetic process GO:0032800 9.43 IL10 TNF
31 negative regulation of growth of symbiont in host GO:0044130 9.43 IL10 MBL2 TNF
32 cytokine-mediated signaling pathway GO:0019221 9.43 IL10 IL4 IL6 TGFB1 TNF VCAM1
33 positive regulation of mononuclear cell migration GO:0071677 9.4 TGFB1 TNF
34 mononuclear cell proliferation GO:0032943 9.32 ACE TGFB1
35 immune response GO:0006955 9.17 HLA-A HLA-DQA1 HLA-DRB1 IL10 IL4 IL6
36 positive regulation of transcription, DNA-templated GO:0045893 10.03 IL10 IL4 IL6 TGFB1 TNF
37 immune system process GO:0002376 10 HLA-A HLA-DQA1 HLA-DRB1 MASP2 MBL2

Molecular functions related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 IL10 IL4 IL6 TGFB1
2 MHC class II receptor activity GO:0032395 9.26 HLA-DQA1 HLA-DRB1
3 peptide antigen binding GO:0042605 9.13 HLA-A HLA-DQA1 HLA-DRB1
4 cytokine activity GO:0005125 9.02 IL10 IL4 IL6 TGFB1 TNF

Sources for Rheumatic Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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