RHD
MCID: RHM028
MIFTS: 53

Rheumatic Heart Disease (RHD)

Categories: Cardiovascular diseases

Aliases & Classifications for Rheumatic Heart Disease

MalaCards integrated aliases for Rheumatic Heart Disease:

Name: Rheumatic Heart Disease 12 54 15 17 71
Rheumatic Congestive Heart Failure 12 15
Congestive Rheumatic Heart Failure 12 71
Rheumatic Heart Failure 12
Rheumatic Carditis 12
Rhd 47

Classifications:



External Ids:

Disease Ontology 12 DOID:0050827 DOID:14172
ICD9CM 34 398.91
SNOMED-CT 67 82523003
UMLS 71 C0035439 C0155582

Summaries for Rheumatic Heart Disease

Disease Ontology : 12 A heart valve disease that is characterized by repeated inflammation with fibrinous repair caused by an autoimmune reaction to Group A beta-hemolytic streptococci (GAS) that results in valvular damage. The cardinal anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords.

MalaCards based summary : Rheumatic Heart Disease, also known as rheumatic congestive heart failure, is related to rheumatic fever-related antigen and neonatal jaundice. An important gene associated with Rheumatic Heart Disease is MIR328 (MicroRNA 328), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Ramipril and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, t cells and lung, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Rheumatic Heart Disease

Diseases related to Rheumatic Heart Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 677)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever-related antigen 32.9 TLR2 MYOM2
2 neonatal jaundice 32.5 TNF IL6 IL10
3 typhoid fever 32.4 TNF IL6 HLA-DRB1
4 toxoplasmosis 32.2 TNF TLR2 TGFB1 IL6 IL4 IL10
5 heart valve disease 32.1 TGFB1 NPPB MYOM2 CNMD ACE
6 mitral valve disease 32.0 NPPB IL4 IL10 ACE
7 cardiovascular system disease 31.8 VCAM1 TNF NPPB IL6 ACE
8 muscular disease 31.7 TNF IL6 IL4 IL10 ACE
9 pharyngitis 31.5 TNF MYOM2 IL6 HLA-DRB1
10 rheumatic fever 31.4 TNF TLR2 NPPB MYOM2 MBL2 IL6
11 heart disease 31.3 VCAM1 TNF TGFB1 NPPB IL6 IL10
12 endocarditis 31.2 VCAM1 TNF TLR2 IL6 IL10
13 rheumatic disease 31.2 VCAM1 TNF MBL2 IL10 HLA-DRB1
14 malaria 31.1 VCAM1 TNF TLR2 TGFB1 MBL2 IL6
15 congestive heart failure 30.9 TNF NPPB IL6 ACE
16 disseminated intravascular coagulation 30.8 TNF IL6 IL10
17 infective endocarditis 30.8 TNF TLR2 IL6 CNMD
18 endomyocardial fibrosis 30.8 TNF IL4 IL10
19 glomerulonephritis 30.7 VCAM1 TGFB1 MBL2 ACE
20 purpura 30.7 TNF IL6 IL4 IL10 ACE
21 vasculitis 30.7 VCAM1 TNF MBL2 IL6
22 tuberculous meningitis 30.7 TNF TLR2 TGFB1
23 pericarditis 30.6 TNF NPPB IL6 ACE
24 pulmonary edema 30.6 TNF NPPB IL10 ACE
25 pericardial effusion 30.6 NPPB IL6 ACE
26 atrial fibrillation 30.5 NPPB IL6 GJA5 ACE
27 appendicitis 30.5 TNF IL6 IL10
28 erysipelas 30.5 TNF MYOM2 IL6
29 tonsillitis 30.5 TNF TLR2 IL6 IL4 IL10
30 sickle cell anemia 30.5 VCAM1 TNF IL6
31 atherosclerosis susceptibility 30.4 VCAM1 TNF IL6 ACE
32 familial mediterranean fever 30.4 TNF TLR2 IL6 IL10
33 peritonitis 30.4 TNF TLR2 IL6 IL4 IL10
34 iritis 30.4 TNF IL6 ACE
35 tetanus 30.4 TNF IL6 IL4 IL10
36 cardiogenic shock 30.4 NPPB IL6
37 angina pectoris 30.4 NPPB IL6 ACE
38 acquired immunodeficiency syndrome 30.3 VCAM1 TNF IL6 IL10
39 atrioventricular block 30.3 NPPB GJA5 ACE
40 polyarteritis nodosa 30.3 VCAM1 IL6 HLA-DRB1
41 spondylitis 30.3 TNF IL6 IL10
42 exanthem 30.2 TNF IL6 IL10 ACE
43 arteries, anomalies of 30.2 VCAM1 TNF NPPB IL6 ACE
44 encephalitis 30.2 VCAM1 TNF IL6 IL10
45 limb ischemia 30.2 TNF IL6 ACE
46 coronary stenosis 30.2 NPPB IL6 ACE
47 viral encephalitis 30.2 VCAM1 TNF IL6 IL10
48 reactive arthritis 30.2 TNF TLR2 IL6 IL10
49 myocarditis 30.2 VCAM1 TNF NPPB IL6 IL4 IL10
50 myositis 30.2 TNF IL6 HLA-DRB1 HLA-DQA1

Comorbidity relations with Rheumatic Heart Disease via Phenotypic Disease Network (PDN): (show all 19)


Active Peptic Ulcer Disease Acute Cystitis
Aortic Valve Disease 1 Aortic Valve Disease 2
Aortic Valve Insufficiency Bronchitis
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Intracranial Embolism
Mitral Valve Disease Mitral Valve Stenosis
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Rheumatic Myocarditis Rheumatic Pulmonary Valve Disease
Sinoatrial Node Disease Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Rheumatic Heart Disease:



Diseases related to Rheumatic Heart Disease

Symptoms & Phenotypes for Rheumatic Heart Disease

MGI Mouse Phenotypes related to Rheumatic Heart Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 ACE GJA5 HLA-DQA1 IL10 IL4 IL6
2 hematopoietic system MP:0005397 9.73 ACE CNMD GJA5 HLA-DQA1 IL10 IL4
3 immune system MP:0005387 9.4 ACE CNMD GJA5 HLA-DQA1 IL10 IL4

Drugs & Therapeutics for Rheumatic Heart Disease

Drugs for Rheumatic Heart Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 126)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ramipril Approved Phase 3 87333-19-5 5362129
2
Warfarin Approved Phase 3 81-81-2 6691 54678486
3
Thrombin Approved, Investigational Phase 3
4
Protein C Approved Phase 3
5
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
6
Phylloquinone Approved, Investigational Phase 3 84-80-0
7
Rivaroxaban Approved Phase 3 366789-02-8
8
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
9 Menaquinone Investigational Phase 3 1182-68-9
10 Natriuretic Peptide, Brain Phase 2, Phase 3
11 Antihypertensive Agents Phase 3
12 Angiotensin-Converting Enzyme Inhibitors Phase 3
13 Antidotes Phase 3
14 protein S Phase 3
15 Vitamin K 1 Phase 3
16
protease inhibitors Phase 3
17 HIV Protease Inhibitors Phase 3
18 Vitamins Phase 3
19 Micronutrients Phase 3
20 Trace Elements Phase 3
21 Antithrombins Phase 3
22 Fibrinolytic Agents Phase 3
23 Anti-Inflammatory Agents Phase 3
24 Platelet Aggregation Inhibitors Phase 3
25 Antipyretics Phase 3
26 Anti-Inflammatory Agents, Non-Steroidal Phase 3
27 Analgesics, Non-Narcotic Phase 3
28 Serine Proteinase Inhibitors Phase 3
29 Anticoagulants Phase 3
30 Cyclooxygenase Inhibitors Phase 3
31 Nutrients Phase 3
32 Hemostatics Phase 3
33 Coagulants Phase 3
34 Antirheumatic Agents Phase 3
35 Vitamin K Phase 3
36 naphthoquinone Phase 3
37 Antifibrinolytic Agents Phase 3
38 Antithrombin III Phase 3
39 Analgesics Phase 3
40 Factor Xa Inhibitors Phase 3
41
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
42
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
43
Procaine Approved, Investigational, Vet_approved Phase 2 59-46-1 4914
44
Penicillin G Approved, Vet_approved Phase 2 61-33-6 5904
45 Free Radical Scavengers Phase 2
46 Antioxidants Phase 2
47 Antiviral Agents Phase 2
48 N-monoacetylcystine Phase 2
49 Respiratory System Agents Phase 2
50 Protective Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Boston Area Anticoagulation Trial for Atrial Fibrillation (BAATAF) Completed NCT00000517 Phase 3 warfarin
2 A Randomized Trial of Pocket-Echocardiography Integrated Mobile Health Device Assessments in Modern Structural Heart Disease Clinics Completed NCT02881398 Phase 2, Phase 3
3 The Effect of Ramipril in Suppressing Gene Expression of Fibrosis in Cardiac Mitral Stenosis in Patients With Rheumatic Heart Disease Recruiting NCT03991910 Phase 3 Placebos;Ramipril 5Mg Oral Capsule
4 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies Recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
5 RIvoraxaban Safety and Efficacy in Patients With Mitral Stenosis Recruiting NCT03926156 Phase 3 Rivaroxaban;Warfarin
6 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
7 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement. Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
8 Intravenous Supplementation of Glutamine Preoperatively for Cardiac Function and Recovery Improvement in Adult Accepting Cardiosurgery: A Randomized, Double-Blinded, Placebo-Controlled Trial Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
9 The GOAL (GwokO Adunu pa Lutino) Trial: Determining the Impact of Penicillin on Latent Rheumatic Heart Disease: A Randomized Controlled Trial in Uganda Active, not recruiting NCT03346525 Phase 2 intramuscular benzathine penicillin G (BPG) prophylaxis
10 Maternal-Fetal Monitoring of Patients With Rheumatic Heart Disease During Dental Procedure Under Local Anesthesia Completed NCT00482573 Phase 1
11 Group A Streptococcal Human Challenge Study: Building a Pharyngitis Model to Accelerate Vaccine Development Active, not recruiting NCT03361163 Phase 1
12 Assessment of Rheumatic Heart Disease Patients With Chronic Severe Mitral Regurge by Speckle Tracking Echocardiography for Proper Timing of Surgical Operation. Unknown status NCT03156972
13 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
14 Clinical Audit on the Managment of Rheumatic Fever in Assiut University Children Hospital Unknown status NCT03281863
15 Bipolar Radiofrequency Ablation Plus Endocardial Ablation Using Argon Beam Coagulator for Atrial Fibrillation Treatment in Patients With Rheumatic Heart Disease Unknown status NCT02424110
16 Comparison Between Outcomes Of Ring And Suture Annuloplasty For Functional Tricuspid Regurgitation In Rheumatic Mitral Valve Diseases Unknown status NCT02721524
17 Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Adherence to Penicillin Secondary Prophylaxis Unknown status NCT03183180
18 Mitochondrial Apoptotic Pathway Induced by Myocardial Ischemia-Reperfusion Injury in Human Unknown status NCT02430116
19 Prevalence and Significance of Mutations in Genes Encoding NaPi-co-transporters in the Development of CAVD Unknown status NCT02516800
20 Integrating Pediatric Care Delivery in Rural Healthcare Systems Unknown status NCT02331082
21 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524
22 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
23 Genome-wide Association Study of Susceptibility to Rheumatic Heart Disease in Fiji and New Caledonia Completed NCT02188862
24 The Genetic Basis of Acquired Heart Disease in Africa Completed NCT02124109
25 Prospective Cohort Study Compares Effect of Corrected and Uncorrected Rheumatic Heart Valve of Pregnant Women on Maternal and Fetal Outcomes Completed NCT03029117
26 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) Part 1: The Prevalence of Rheumatic Heart Disease, Pyoderma and Scabies in School Children in Fiji Completed NCT00284843
27 The Cardiac Protective Effect of Simvastatin on Cardiac Surgery: a Double Blind, Randomised Clinical Trial Completed NCT01178710 Simvastatin
28 Effect of Remote Ischemia Preconditioning on Myocardial Injury in Patients Undergoing Heart Valve Surgery Completed NCT01175681
29 Study of the Prevalence of Rheumatic Heart Disease in Leon, Nicaragua Completed NCT00307112
30 Prevalence of Rheumatic Heart Disease in Pregnancy Among a Population of Antenatal Patients at a Tertiary Care Institution in Western Kenya Completed NCT03411993
31 Change of Serum Tenascin-C Concentration and the Relationship With Hs-CRP,cTnI and Prognosis in Patients With Acute Coronary Syndrome Completed NCT02767960
32 A Population-Based Study of Prevalence of Rheumatic Heart Disease and Cardiovascular Outcomes Among Schoolchildren in Nepal Completed NCT01550068
33 The Hospital Based Incidence of Acute Rheumatic Fever and Rheumatic Heart Disease, Acute Post Streptococcal Glomerulonephritis and Invasive Group A Streptococcal Disease in Fiji Completed NCT00264771
34 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration in Patients With Rheumatic Heart Disease Completed NCT01426776
35 Pilot, Randomized,Single Blind Trial of Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion Completed NCT02474108
36 Prevalence of Rheumatic Heart Disease in Zambian Schoolchildren: an Echocardiographic Screening Study Involving Task-shifting to General Radiographers Completed NCT02661763
37 Gulf aCute heArt failuRe rEgistry (Gulf CARE) Completed NCT01467973
38 Epidemiological Surveillance in India of Group A Streptococcal Infections Including Pharyngitis and Impetigo Supported by Indo-US Vaccine Action Program Completed NCT00342199
39 The Epidemiology of Group A Streptococcal Infections in Fiji (Fiji GrASP) - Part 5: Establishing Natural Age-Related Titers of Antibodies to the J8 Group A Streptococcal Epitope in Fiji Completed NCT00264784
40 Role of Phase Contrast Magnetic Resonance in Regurgitant Valvular Heart Diseases Completed NCT03669666
41 The First Affiliated Hospital of Nanjing Medical University Completed NCT02349997
42 Outcome of MC3 Ring Annuloplasty for Moderate and Severe Functional Tricuspid Regurgitation Associated With Rheumatic Mitral Valve Disease Completed NCT04078867
43 The Molecular Epidemiology of Streptococcus Pyogenes Among Children in Bamako, Mali (Bamako BGAS2000) Completed NCT00305123
44 The Pan African Pulmonary Hypertension Cohort Study Completed NCT02265887
45 Intravenous Immunoglobulins as Effective Treatment in Sydenham's Chorea Completed NCT00615797 standard interventions penicillin VK and haloperidol
46 Different Modalities for Evaluation of Fetal Cardiac Function in Pregnant Women With Rheumatic Heart Disease (RHD) Patients Recruiting NCT03095937
47 Next Generation Sequencing Approach to the Study of Rheumatic Heart Disease Recruiting NCT02118818
48 Study of the Prognosis of Infectious Endocarditis (EPEI): Prospective and Retrospective Follow-up of a Cohort of Patients Hospitalized for Infectious Endocarditis Recruiting NCT03211975
49 National Institute of Health Research (NIHR) Global Health Research Group on Warfarin Anticoagulation in Patients With Cardiovascular Disease in Sub-Saharan Africa Recruiting NCT03512080
50 The Impact Of Adipokines Levels In Patients With Atrial Fibrillation Recruiting NCT03592732

Search NIH Clinical Center for Rheumatic Heart Disease

Genetic Tests for Rheumatic Heart Disease

Anatomical Context for Rheumatic Heart Disease

MalaCards organs/tissues related to Rheumatic Heart Disease:

40
Heart, T Cells, Lung, Testes, Thyroid, Kidney, Liver

Publications for Rheumatic Heart Disease

Articles related to Rheumatic Heart Disease:

(show top 50) (show all 4308)
# Title Authors PMID Year
1
MicroRNA-328 contributes to adverse electrical remodeling in atrial fibrillation. 61 46
21098446 2010
2
Synergistic effect of mitral expression of tissue inhibitor of metalloproteinase-2 with hypertension on the occurrence of mitral chordae tendinae rupture. 54 61
19727008 2009
3
High-producing MBL2 genotypes increase the risk of acute and chronic carditis in patients with history of rheumatic fever. 54 61
18602696 2008
4
The association between mannose-binding lectin gene polymorphism and rheumatic heart disease. 54 61
17174748 2006
5
Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis. 54 61
16980969 2006
6
Significantly increased levels of mannose-binding lectin (MBL) in rheumatic heart disease: a beneficial role for MBL deficiency. 54 61
15544631 2004
7
To reply the letter by Zhong et al. entitled "Should the distribution of valve lesion be considered in the autoimmune response of rheumatic heart disease?" 61
31932117 2020
8
HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia. 61
31994854 2020
9
Anti-streptococcal antibody and T-cell interactions with vascular endothelial cells initiate the development of rheumatic carditis. 61
31617241 2020
10
Early and long-term outcomes of decompensated heart failure patients in a tertiary-care centre in India. 61
32012491 2020
11
Inhibition of miR‑155‑5p attenuates the valvular damage induced by rheumatic heart disease. 61
31894293 2020
12
Circulating follicular T helper cells and humoral reactivity in rheumatic heart disease. 61
32007574 2020
13
Paths to improved rheumatic heart disease: screening and prophylaxis. 61
31916530 2020
14
The high prevalence and impact of rheumatic heart disease in pregnancy in First Nations populations in a high-income setting: a prospective cohort study. 61
31512355 2020
15
Management of Ruptured Left Ventricular Outflow Tract. 61
31229479 2020
16
Short-term competency of aortic valve repair in Egyptian patients. 61
31981423 2020
17
Incidence, Risk Factors and Subsequent Prognostic Impact of New-Onset Atrial Fibrillation in Infective Endocarditis. 61
31839653 2020
18
Polyacrylate-Peptide Antigen Conjugate as a Single-Dose Oral Vaccine against Group A Streptococcus. 61
31941060 2020
19
Prevalence of Group A β-hemolytic Streptococcal Throat Carriage and Prospective Pilot Surveillance of Streptococcal Sore Throat in Ugandan School Children. 61
31972290 2020
20
Warfarin induced leukocytoclastic vasculitis: an extraordinary side effect. 61
31375992 2020
21
Systems immunology reveals a linked IgG3-C4 response in patients with acute rheumatic fever. 61
31742781 2020
22
Acute rheumatic fever prophylaxis in high-income countries: clinical observations from an Italian multicentre, retrospective study. 61
31969217 2020
23
Changes in valvular regurgitation in mid-term follow-up of children with first attack acute rheumatic fever: first evaluation after the updated Jones criteria. 61
31920190 2020
24
Rheumatic Fever and Rheumatic Heart Disease in Children. 61
31925717 2020
25
Screening and evaluation of newly diagnosed cardiovascular diseases in first-trimester asymptomatic pregnant women in a tertiary antenatal care center in Turkey. 61
32011322 2020
26
The polymorphism at the microRNA-155 binding site in AGTR1 gene is not significantly associated with rheumatic heart disease in Saudi Arabia population. 61
31912773 2020
27
Treatment outcome and its predictors among patients of acute heart failure at a tertiary care hospital in Ethiopia: a prospective observational study. 61
31959121 2020
28
Echocardiographic screening for rheumatic heart disease in Turkish school children. 61
31854284 2019
29
Standardizing clinical care measures of rheumatic heart disease in pregnancy: A qualitative synthesis. 61
31150150 2019
30
Genomic analysis of lncRNA and mRNA profiles in circulating exosomes of patients with rheumatic heart disease. 61
31784421 2019
31
The prognostic value of postoperative blood glucose in non-diabetic patients with rheumatic heart disease. 61
31847835 2019
32
Preclinical evaluation of a transcatheter aortic valve replacement system for patients with rheumatic heart disease. 61
31403458 2019
33
Evolving trends in infective endocarditis in a developing country: a consequence of medical progress? 61
31847847 2019
34
Does genetics matter for disease-related stigma? The impact of genetic attribution on stigma associated with rheumatic heart disease in the Western Cape, South Africa. 61
31715540 2019
35
The risk of intramuscular haematoma is low following injection of benzathine penicillin G in patients receiving concomitant anticoagulant therapy. 61
31820262 2019
36
A Validation Study: How Predictive Is a Diagnostic Coding Algorithm at Identifying Rheumatic Heart Disease in Western Australian Hospital Data? 61
31959553 2019
37
Comparison of the newer proposed diagnostic score with the World Heart Federation criteria for echocardiographic detection of rheumatic heart disease. 61
31769064 2019
38
Long-term outcomes of radiofrequency catheter ablation for atrial fibrillation in rheumatic heart disease patients with mild mitral stenosis. 61
31055689 2019
39
Percutaneous mitral balloon valvulotomy in pregnant women with mitral stenosis from rheumatic heart disease: a series of cases. 61
31854197 2019
40
A review of the epidemiology of atrial fibrillation in sub-Saharan Africa. 61
31596016 2019
41
Prevalence, Clinical Features and Antibiotic Susceptibility of Group A Streptococcal Skin Infections in School Children in Urban Western and Northern Uganda. 61
31568247 2019
42
ABO blood group influences risk of venous thromboembolism and myocardial infarction. 61
31820263 2019
43
[CURRENT TRENDS IN THE PREVENTION, DIAGNOSIS AND TREATMENT OF RHEUMATIC FEVER AND RHEUMATIC HEART DISEASE (REVIEW)]. 61
32011302 2019
44
Gut Microbial Metabolite Trimethylamine N-Oxide Is Related to Thrombus Formation in Atrial Fibrillation Patients. 61
31666184 2019
45
Spectrum of heart diseases in children presenting to a paediatric cardiac echocardiography clinic in the Lake Zone of Tanzania: a 7 years overview. 61
31835996 2019
46
Intracardiac Thrombus Following Rivaroxaban Treatment in a Patient with Atrial Fibrillation Associated with Rheumatic Heart Disease. 61
31427189 2019
47
Rheumatic heart disease in pregnancy: Profile of women admitted to a Western Australian tertiary obstetric hospital. 61
31782139 2019
48
[The role of ADRB1 genes polymorphism in examined patients with chronic rheumatic heart disease]. 61
31884750 2019
49
Rheumatic fever and rheumatic heart disease: Facts and research progress in Africa. 61
31405583 2019
50
Prevalence and progression of rheumatic heart disease: a global systematic review and meta-analysis of population-based echocardiographic studies. 61
31745178 2019

Variations for Rheumatic Heart Disease

Expression for Rheumatic Heart Disease

Search GEO for disease gene expression data for Rheumatic Heart Disease.

Pathways for Rheumatic Heart Disease

Pathways related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 VCAM1 TNF TGFB1 IL6 IL4 IL10
2
Show member pathways
13.1 TNF TLR2 TGFB1 MBL2 IL6 IL10
3
Show member pathways
13.04 VCAM1 TIMP4 TGFB1 IL6 IL4 ACE
4
Show member pathways
12.82 TNF TGFB1 IL6 IL4 IL10 HLA-DRB1
5
Show member pathways
12.8 TNF TLR2 IL6 HLA-DRB1 HLA-DQA1
6 12.78 TNF TLR2 IL6 HLA-DRB1 HLA-DQA1
7
Show member pathways
12.69 TNF TLR2 TIMP4 TGFB1 IL6
8
Show member pathways
12.62 TNF IL4 IL10 HLA-DRB1 HLA-DQA1
9
Show member pathways
12.59 TNF TLR2 TGFB1 IL6 IL4 IL10
10 12.56 VCAM1 TNF TLR2 IL4 IL10
11
Show member pathways
12.51 TNF TLR2 TGFB1 IL6 IL4 IL10
12
Show member pathways
12.32 TNF TLR2 IL6 IL4
13 12.32 TNF TGFB1 IL6 HLA-DRB1 HLA-DQA1
14
Show member pathways
12.24 TNF TGFB1 IL6 ACE
15
Show member pathways
12.24 TNF TIMP4 TGFB1 IL6 IL4 IL10
16 12.18 TNF TLR2 TGFB1 IL6
17
Show member pathways
12.17 TNF TLR2 IL6 IL4
18 12.13 TLR2 MBL2 HLA-DRB1 HLA-DQA1
19
Show member pathways
12.08 TNF TLR2 TGFB1 IL4 IL10 HLA-DRB1
20
Show member pathways
12.03 TNF TLR2 IL6 IL4
21
Show member pathways
12.02 TNF TLR2 TGFB1 IL6 IL10
22 12 TNF TGFB1 IL6 IL4
23 11.97 TNF IL6 IL4 IL10
24 11.96 TNF TLR2 TGFB1 IL6 IL10 HLA-DRB1
25 11.94 VCAM1 TNF TGFB1 IL6 IL4 IL10
26 11.9 VCAM1 TNF TGFB1 IL6
27 11.88 TNF TLR2 TGFB1 IL6 IL10
28 11.87 MBL2 IL10 HLA-DRB1 HLA-DQA1
29 11.85 TNF IL6 IL4 HLA-DRB1 HLA-DQA1
30 11.77 TNF IL4 IL10
31 11.77 TNF TLR2 TGFB1 IL6 HLA-DRB1 HLA-DQA1
32 11.75 TNF TGFB1 IL6 IL10
33 11.74 TNF IL6 IL10
34 11.68 TNF TGFB1 IL6 IL4 IL10
35
Show member pathways
11.65 VCAM1 TNF IL6
36 11.65 TNF TGFB1 IL6 IL4
37 11.6 TNF TLR2 IL6
38 11.52 TNF IL6 IL4 IL10
39 11.36 VCAM1 TNF IL6 IL10
40 11.35 TNF IL6 IL10
41 11.29 TNF IL6 IL4
42 11.13 VCAM1 TNF TLR2 TGFB1 IL6 IL10
43 11.02 TNF TIMP4 TGFB1 IL6 IL4 IL10
44 10.56 TNF TGFB1 IL6 IL4 IL10 HLA-DRB1

GO Terms for Rheumatic Heart Disease

Cellular components related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TNF TIMP4 TGFB1 NPPB MBL2 IL6
2 cell surface GO:0009986 9.63 VCAM1 TNF TLR2 TGFB1 MBL2 HLA-DRB1
3 extracellular space GO:0005615 9.36 VCAM1 TNF TIMP4 TGFB1 NPPB MIR328

Biological processes related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.03 TNF TLR2 TGFB1 IL6 IL4
2 inflammatory response GO:0006954 9.99 TNF TLR2 TGFB1 IL6 IL10
3 response to lipopolysaccharide GO:0032496 9.88 VCAM1 TLR2 TIMP4 IL10
4 B cell differentiation GO:0030183 9.84 VCAM1 IL4 IL10
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 TNF IL6 IL4
6 interferon-gamma-mediated signaling pathway GO:0060333 9.83 VCAM1 HLA-DRB1 HLA-DQA1
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 TNF TLR2 TGFB1 IL6
8 response to glucocorticoid GO:0051384 9.8 TNF IL6 IL10
9 positive regulation of T cell proliferation GO:0042102 9.78 VCAM1 IL6 IL4
10 positive regulation of interleukin-6 production GO:0032755 9.77 TNF TLR2 IL6
11 negative regulation of fat cell differentiation GO:0045599 9.74 TNF TGFB1 IL6
12 negative regulation of T cell proliferation GO:0042130 9.71 TGFB1 IL10 HLA-DRB1
13 negative regulation of mitotic cell cycle GO:0045930 9.67 TNF TGFB1 IL10
14 response to organic substance GO:0010033 9.67 TNF TIMP4 TGFB1 IL10
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.66 IL4 IL10
16 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.66 IL4 IL10
17 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
18 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TNF TLR2 TGFB1
19 opsonization GO:0008228 9.64 MBL2 FCN2
20 complement activation, lectin pathway GO:0001867 9.64 MBL2 FCN2
21 cytokine-mediated signaling pathway GO:0019221 9.63 VCAM1 TNF TGFB1 IL6 IL4 IL10
22 endothelial cell apoptotic process GO:0072577 9.62 TNF IL10
23 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.62 TIMP4 IL10
24 neutrophil mediated immunity GO:0002446 9.61 IL6 ACE
25 positive regulation of JAK-STAT cascade GO:0046427 9.61 TNF IL6 IL10
26 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 TNF IL10
27 positive regulation of mononuclear cell migration GO:0071677 9.56 TNF TGFB1
28 type 2 immune response GO:0042092 9.55 IL4 IL10
29 regulation of isotype switching GO:0045191 9.51 IL4 IL10
30 regulation of blood vessel diameter GO:0097746 9.5 NPPB GJA5 ACE
31 immune response GO:0006955 9.5 TNF TLR2 IL6 IL4 IL10 HLA-DRB1
32 receptor biosynthetic process GO:0032800 9.46 TNF IL10
33 positive regulation of chemokine production GO:0032722 9.43 TNF TLR2 IL6
34 mononuclear cell proliferation GO:0032943 9.4 TGFB1 ACE
35 defense response to Gram-positive bacterium GO:0050830 9.02 TNF TLR2 MBL2 IL6 FCN2

Molecular functions related to Rheumatic Heart Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 TGFB1 IL6 IL4 IL10
2 MHC class II receptor activity GO:0032395 9.16 HLA-DRB1 HLA-DQA1
3 cytokine activity GO:0005125 9.02 TNF TGFB1 IL6 IL4 IL10

Sources for Rheumatic Heart Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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