Rheumatic Myocarditis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MalaCards based summary: Rheumatic Myocarditis, also known as acute rheumatic myocarditis, is related to myocarditis and mitral valve insufficiency. An important gene associated with Rheumatic Myocarditis is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Cardiac progenitor differentiation. Affiliated tissues include heart, neutrophil and brain.

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Related Diseases for Rheumatic Myocarditis

Diseases related to Rheumatic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)

#	Related Disease	Score	Top Affiliating Genes
1	myocarditis	30.9	TNNT2 TNNI3 MB
2	mitral valve insufficiency	30.7	TNNT2 TNNI3 CRP
3	acute poststreptococcal glomerulonephritis	30.7	MYOM2 CRP
4	pharyngitis	30.4	MYOM2 CRP
5	cardiac tamponade	30.3	TNNI3 CRP
6	pericarditis	30.2	TNNT2 TNNI3 CRP
7	heart septal defect	30.2	TNNT2 CRP
8	atrioventricular block	30.1	TNNT2 TNNI3 CRP
9	third-degree atrioventricular block	30.1	TNNI3 CRP
10	endocarditis	30.0	TNNT2 TNNI3 CRP
11	acute myocarditis	29.7	TNNT2 TNNI3 CRP
12	aortic valve insufficiency	29.7	TNNI3 MIR374B CRP
13	hypertrophic cardiomyopathy	29.4	TNNT2 TNNI3 MYOM2 CRP
14	heart valve disease	29.3	TNNT2 TNNI3 MYOM2 MIR374B CRP
15	pericardial effusion	29.2	TNNT2 TNNI3 MB CRP
16	dilated cardiomyopathy	29.0	TNNT2 TNNI3 MYOM2 MB CRP
17	rheumatic fever	10.5
18	orthostatic intolerance	10.3
19	glomerulonephritis	10.3
20	rheumatic heart disease	10.2
21	henoch-schoenlein purpura	10.2
22	choreatic disease	10.2
23	purpura	10.2
24	aortic valve prolapse	10.2
25	streptococcal meningitis	10.2	MYOM2 CRP
26	gastric dilatation	10.2	TNNI3 CRP
27	mononeuritis of upper limb and mononeuritis multiplex	10.2	MYOM2 CRP
28	hemopericardium	10.2	TNNI3 CRP
29	lethal congenital contracture syndrome 4	10.2	TNNI3 MYOM2
30	acute cor pulmonale	10.2	TNNI3 CRP
31	scarlet fever	10.2	MYOM2 CRP
32	acute pulmonary heart disease	10.2	TNNI3 CRP
33	first-degree atrioventricular block	10.2	TNNI3 CRP
34	multicentric castleman disease	10.2	MYOM2 CRP
35	castleman disease	10.2	MYOM2 CRP
36	heart cancer	10.2	TNNI3 CRP
37	necrotizing fasciitis	10.2	MYOM2 CRP
38	non-severe covid-19	10.2	TNNI3 CRP
39	erysipelas	10.1	MYOM2 CRP
40	septic arthritis	10.1	MYOM2 CRP
41	papilledema	10.1	MYOM2 CRP
42	familial isolated restrictive cardiomyopathy	10.1	TNNT2 TNNI3
43	demyelinating polyneuropathy	10.1	MYOM2 CRP
44	coronary thrombosis	10.1	TNNI3 CRP
45	inferior myocardial infarction	10.1	TNNT2 TNNI3
46	cellulitis	10.1	MYOM2 CRP
47	plasma protein metabolism disease	10.1	MYOM2 CRP
48	nerve compression syndrome	10.1	GSN CRP
49	pyoderma	10.1	MYOM2 CRP
50	cardiomyopathy, dilated, 1b	10.1	TNNT2 TNNI3

Comorbidity relations with Rheumatic Myocarditis via Phenotypic Disease Network (PDN):

Familial Atrial Fibrillation	Heart Disease
Mitral Valve Disease	Mitral Valve Stenosis
Rheumatic Heart Disease

Graphical network of the top 20 diseases related to Rheumatic Myocarditis:

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Symptoms & Phenotypes for Rheumatic Myocarditis

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Drugs & Therapeutics for Rheumatic Myocarditis

Search Clinical Trials, NIH Clinical Center for Rheumatic Myocarditis

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Genetic Tests for Rheumatic Myocarditis

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Anatomical Context for Rheumatic Myocarditis

Organs/tissues related to Rheumatic Myocarditis:

MalaCards : Heart, Neutrophil, Brain, Pituitary

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Publications for Rheumatic Myocarditis

Articles related to Rheumatic Myocarditis:

(show top 50) (show all 218)

#	Title	Authors	PMID	Year
1	Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study. ⁶²	Okello E...Beaton A	34419237	2021
2	An evidence-based scoring system to diagnose acute rheumatic fever with carditis in children. ⁶²	Narang R...Kothari SS	33667575	2021
3	Cardiac Immunology: A New Era for Immune Cells in the Heart. ⁶²	Koc A...Cagavi E	32910424	2021
4	Rheumatic Myocarditis: A Poorly Recognized Etiology of Left Ventricular Dysfunction in Valvular Heart Disease Patients. ⁶²	Rosa VEE...Tarasoutchi F	34179142	2021
5	Characteristics of Children with Acute Rheumatic Carditis from a High-Incidence Region: Importance of Unexplained Worsening of Functional Class. ⁶²	Narang R...Kothari SS	32526745	2020
6	Evaluation of ventricular arrhythmogenesis in children with acute rheumatic carditis. ⁶²	Kucuk M...Mese T	30160770	2018
7	The neutrophil-to-lymphocyte ratio and mean platelet volume can be associated with severity of valvular involvement in patients with acute rheumatic carditis. ⁶²	Celik SF...Celik E	30198547	2018
8	Systolic aortic regurgitation in rheumatic carditis: Mechanistic insight by Doppler echocardiography. ⁶²	Mohan JC...Sethi A	29716706	2018
9	Henoch-Schonlein purpura, post-streptococcal glomerulonephritis and acute rheumatic carditis after Group A β-haemolytic streptococcal infection. ⁶²	Arslansoyu Camlar S...Kavukcu S	28162051	2018
10	Acute rheumatic fever presenting as complete heart block: report of an adolescent case and review of literature. ⁶²	Umapathy S...Saxena A	29440244	2018
11	A rare situation in acute rheumatic carditis: Involvement of all four valves. ⁶²	Guvenc O...Cimen D	29624235	2017
12	Parameters indicative of persistence of valvular pathology at initial diagnosis in acute rheumatic carditis: the role of albumin and CD19 expression. ⁶²	Oner T...Genel F	27553592	2016
13	Red blood cell distribution width: can it be a predictive marker for long-term valvular involvement in children with acute rheumatic carditis? ⁶²	Kucuk M...Unal N	27435353	2016
14	Acute Rheumatic Carditis: A Rare Cause for Reversible Complete Heart Block. ⁶²	Abdul Ghani OA...Singh D	26535164	2015
15	Plasma gelsolin as a biomarker of acute rheumatic carditis. ⁶²	Argun M...Narin N	25403731	2015
16	Heart Transplant in Patients with Predominantly Rheumatic Valvular Heart Disease. ⁶²	Rosa VE...Tarasoutchi F	26897843	2015
17	Heart lesion after the first attack of the rheumatic Fever 22 years experience in single centre. ⁶²	Bejiqi RA...Retkoceri A	25870479	2015
18	The role of 18F fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in children with rheumatic carditis and chronic rheumatic heart disease. ⁶²	Nagesh CM...Malhotra A	25633513	2015
19	Importance of N-terminal pro-brain natriuretic peptide in monitoring acute rheumatic carditis. ⁶²	Esen F...Narin N	24161016	2015
20	Are mean platelet volume and platelet distribution width useful parameters in children with acute rheumatic carditis? ⁶²	Ozdemir R...Unal N	23780555	2014
21	Incidental histological diagnosis of acute rheumatic myocarditis: case report and review of the literature. ⁶²	Spina GS...Tarasoutchi F	25478552	2014
22	Association of heart block with uncommon disease States. ⁶²	Yahalom M...Turgeman Y	24436606	2013
23	[Acute rheumatic carditis in Ivory Coast: changes in prevalence during the decade 2000-2009]. ⁶²	Kramoh KE...Kakou-Guikahue M	22560250	2013
24	N-Terminal proBNP Levels and Tissue Doppler Echocardiography in Acute Rheumatic Carditis. ⁶²	Kotby AA...El Shafey RN	24109516	2013
25	Adams-Stokes attack as the first symptom of acute rheumatic fever: report of an adolescent case and review of the literature. ⁶²	Carano N...Agnetti A	23110777	2012
26	Diagnosis of acute rheumatic carditis: An echo in time…. ⁶²	Karthikeyan G	23129898	2012
27	Antistreptolysin O titer in health and disease: levels and significance. ⁶²	Kotby AA...Ezz El Elarab S	22690314	2012
28	Ongoing inflammation in children with rheumatic heart disease. ⁶²	Habeeb NM...Al Hadidi IS	21303581	2011
29	A dramatic decline in university hospital admissions of acute rheumatic fever in the eastern region of Saudi Arabia. ⁶²	Abdul-Mohsen MF...Lardhi AA	23960643	2011
30	Cardiac troponin T in children with acute rheumatic carditis. ⁶²	Ozdemir O...Olgunturk R	20957477	2011
31	[Radionuclide methods for diagnostics of non-rheumatic myocarditis and postmyocarditic cardiosclerosis]. ⁶²	Sazonova SI...Lishmanov IuB	21574439	2011
32	[Non-rheumatic myocarditis in practice of outpatient therapist and cardiologist]. ⁶²	Bart BIa...Brodskii MS	21446195	2011
33	The role of viral agents in aetiopathogenesis of acute rheumatic fever. ⁶²	Olgunturk R...Tunaoglu S	20401762	2011
34	Aortic valve repair by cusp extension for rheumatic aortic insufficiency in children: Long-term results and impact of extension material. ⁶²	Myers PO...Kalangos A	20659746	2010
35	QT Dispersion predicting acute rheumatic carditis. ⁶²	Remigio de Aguiar MI...Santos CL	20557664	2010
36	Acute rheumatic carditis associated with Schoenlein-Henoch vasculitis. ⁶²	Sen TA...Narci A	20929708	2010
37	Release of N-terminal pro-brain natriuretic peptide in children with acute rheumatic carditis. ⁶²	Cimen O...Buyukbas S	20416140	2010
38	Induction of myocarditis lesions in Lewis rats by formalin-killed cells of group A Streptococcus. ⁶²	Huang J...Gu JR	19215688	2009
39	[The pathologists: Aschoff, Klinge and Gräff]. ⁶²	Keitel W	18309501	2008
40	Assessment of myocardial involvement using cardiac troponin-I and echocardiography in rheumatic carditis in Izmir, Turkey. ⁶²	Tavli V...Atlihan F	18279207	2008
41	The prolongation of the QT interval in the acute rheumatic carditis: an enigma. ⁶²	Saraiva LR...de Aguiar IR	17262097	2006
42	Rheumatic myocarditis masquerading as left ventricle tumor. ⁶²	Kothari SS...Ray R	16966590	2006
43	QT dispersion in acute rheumatic fever. ⁶²	Polat TB...Celebi A	16553975	2006
44	[Asymptomatic myocarditis after infection of the upper respiratory tract]. ⁶²	Ramazzina C...Eriksson U	15902618	2005
45	Henoch schonlein purpura with rheumatic carditis. ⁶²	Gulati T...Anand VK	15107527	2004
46	Flail posterior leaflet of the mitral valve in acute rheumatic carditis. ⁶²	Haizlip JA...Tani LY	15039879	2004
47	Treatment of acute rheumatic carditis with choline magnesium trisalicylate in a patient needing surgery. ⁶²	Moffett BS...Bricker JT	23118684	2003
48	Does rheumatic myocarditis really exists? Systematic study with echocardiography and cardiac troponin I blood levels. ⁶²	Kamblock J...Papouin G	12727153	2003
49	Is pentoxifylline therapy effective for the treatment of acute rheumatic carditis? A pilot study. ⁶²	Narin N...Halici C	12654146	2003
50	Evidence for lack of myocardial injury in children with acute rheumatic carditis. ⁶²	Williams RV...Tani LY	12635999	2002

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Genes for Rheumatic Myocarditis

Genes related to Rheumatic Myocarditis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYOM2	Myomesin 2	Protein Coding	5.58	DISEASES inferred ¹⁴
2	TNNI3	Troponin I3, Cardiac Type	Protein Coding	5.49	DISEASES inferred ¹⁴
3	CRP	C-Reactive Protein	Protein Coding	5.25	DISEASES inferred ¹⁴
4	MIR379	MicroRNA 379	RNA Gene	4.69	DISEASES inferred ¹⁴
5	GSN	Gelsolin	Protein Coding	4.54	DISEASES inferred ¹⁴
6	MIR374B	MicroRNA 374b	RNA Gene	4.47	DISEASES inferred ¹⁴
7	MB	Myoglobin	Protein Coding	4.33	DISEASES inferred ¹⁴
8	OAT	Ornithine Aminotransferase	Protein Coding	4.23	DISEASES inferred ¹⁴
9	TNNT2	Troponin T2, Cardiac Type	Protein Coding	4.2	DISEASES inferred ¹⁴

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Variations for Rheumatic Myocarditis

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Expression for Rheumatic Myocarditis

Search GEO for disease gene expression data for Rheumatic Myocarditis.

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Pathways for Rheumatic Myocarditis

Pathways related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Cytoskeletal Signaling ³	11.29	TNNT2 TNNI3 GSN
2	Cardiac progenitor differentiation ⁷⁴	10.68	TNNT2 TNNI3

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GO Terms for Rheumatic Myocarditis

Cellular components related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	troponin complex	GO:0005861	9.46	TNNT2 TNNI3
2	cardiac myofibril	GO:0097512	9.26	TNNT2 TNNI3
3	cardiac Troponin complex	GO:1990584	8.92	TNNT2 TNNI3

Biological processes related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ventricular cardiac muscle tissue morphogenesis	GO:0055010	9.56	TNNT2 TNNI3
2	negative regulation of ATP-dependent activity	GO:0032780	9.26	TNNT2 TNNI3
3	regulation of muscle contraction	GO:0006937	9.16	TNNT2 TNNI3
4	muscle contraction	GO:0006936	9.02	TNNT2 TNNI3 MYOM2

Molecular functions related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	troponin C binding	GO:0030172	8.92	TNNT2 TNNI3

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Sources for Rheumatic Myocarditis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: RHM008 MIFTS: 34	Rheumatic Myocarditis Categories: Bone diseases, Cardiovascular diseases, Infectious diseases	Data Licensing For inquiries, contact: [email protected]
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