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MCID: RHM008
MIFTS: 38

Rheumatic Myocarditis

Categories: Bone diseases, Cardiovascular diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Rheumatic Myocarditis

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MalaCards integrated aliases for Rheumatic Myocarditis:

Name: Rheumatic Myocarditis 12 15 33
Acute Rheumatic Myocarditis 12 72 33
Active Rheumatic Fever with Myocarditis 12
Rheumatic Degeneration of Myocardium 12
Rheumatic Fever with Myocarditis 12
Acute Rheumatic Heart Disease 72
Acute Rheumatic Carditis 12
Rheumatoid Myocarditis 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Cardiovascular diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:8481
ICD9CM 35 391.9 398.0
NCIt 50 C34985
SNOMED-CT 68 4536006 8805001
UMLS 72 C0035440 C0155557 C0489959
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Summaries for Rheumatic Myocarditis

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MalaCards based summary : Rheumatic Myocarditis, also known as acute rheumatic myocarditis, is related to rheumatic fever-related antigen and myocarditis. An important gene associated with Rheumatic Myocarditis is TNNI3 (Troponin I3, Cardiac Type), and among its related pathways/superpathways are Innate Immune System and Toxoplasmosis. The drugs Abatacept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart and testes, and related phenotype is integument.

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Related Diseases for Rheumatic Myocarditis

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Diseases related to Rheumatic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 rheumatic fever-related antigen 10.9
2 myocarditis 10.8
3 mitral valve insufficiency 10.5
4 pericardium disease 10.4 TNNI3 CRP
5 intermediate coronary syndrome 10.4 TNNI3 CRP
6 bronchus cancer 10.4 POMC CRP
7 lung oat cell carcinoma 10.4 POMC OAT
8 lobomycosis 10.3 CD2 CD19
9 extrinsic cardiomyopathy 10.3 TNNI3 CRP
10 orthostatic intolerance 10.3
11 acute poststreptococcal glomerulonephritis 10.3
12 glomerulonephritis 10.3
13 lymphoid interstitial pneumonia 10.2 CRP CD8A
14 infective endocarditis 10.2 TNNI3 CRP
15 cutaneous solitary mastocytoma 10.2 POMC CD2
16 endocarditis 10.2
17 pericarditis 10.2
18 purpura 10.2
19 aortic valve prolapse 10.2
20 atrioventricular block 10.2
21 rheumatic fever 10.2
22 aortic valve disease 1 10.2 TNNI3 POMC CRP
23 polyclonal hypergammaglobulinemia 10.1 CD8A CD2
24 specific bursitis often of occupational origin 10.1 CD8A CD2
25 olecranon bursitis 10.1 CD8A CD2
26 rheumatic disease 10.1
27 enthesopathy 10.1
28 lymphatic system cancer 10.1 CD2 CD19
29 pericoronitis 10.0 CRP CD2 CD19
30 cardiac conduction defect 10.0
31 cd4/cd8 t-cell ratio 10.0
32 chorea, childhood-onset, with psychomotor retardation 10.0
33 henoch-schoenlein purpura 10.0
34 heart disease 10.0
35 cardiac tamponade 10.0
36 nephrotic syndrome 10.0
37 choreatic disease 10.0
38 dilated cardiomyopathy 10.0
39 acute proliferative glomerulonephritis 10.0
40 ventricular septal defect 10.0
41 heart septal defect 10.0
42 pharyngitis 10.0
43 subacute bacterial endocarditis 10.0
44 proliferative glomerulonephritis 10.0
45 influenza 10.0
46 vasculitis 10.0
47 streptococcal group a invasive disease 10.0
48 cardiogenic shock 10.0
49 rheumatic heart disease 10.0
50 appendicitis 10.0 CRP CD19

Comorbidity relations with Rheumatic Myocarditis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Mitral Valve Disease Mitral Valve Stenosis
Rheumatic Heart Disease

Graphical network of the top 20 diseases related to Rheumatic Myocarditis:



Diseases related to Rheumatic Myocarditis
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Symptoms & Phenotypes for Rheumatic Myocarditis

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MGI Mouse Phenotypes related to Rheumatic Myocarditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 CD19 CD8A GSN IL1A OAT POMC
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Drugs & Therapeutics for Rheumatic Myocarditis

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Drugs for Rheumatic Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4 332348-12-6 10237
2
Adalimumab Approved Phase 4 331731-18-1 16219006
3 Immunologic Factors Phase 4
4 Immunosuppressive Agents Phase 4
5 Anti-Inflammatory Agents Phase 4
6 Antirheumatic Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Abatacept on Myocarditis in Rheumatoid Arthritis Not yet recruiting NCT03619876 Phase 4 Abatacept;Adalimumab

Search NIH Clinical Center for Rheumatic Myocarditis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Betamethasone
Bupivacaine
Cortisone acetate
Dexamethasone
Methylprednisolone
Prednisolone
Triamcinolone
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Genetic Tests for Rheumatic Myocarditis

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Anatomical Context for Rheumatic Myocarditis

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MalaCards organs/tissues related to Rheumatic Myocarditis:

41
Heart, Testes
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Publications for Rheumatic Myocarditis

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Articles related to Rheumatic Myocarditis:

(show top 50) (show all 93)
# Title Authors PMID Year
1
Heart Transplant in Patients with Predominantly Rheumatic Valvular Heart Disease. 38
26897843 2015
2
Incidental histological diagnosis of acute rheumatic myocarditis: case report and review of the literature. 38
25478552 2014
3
[Radionuclide methods for diagnostics of non-rheumatic myocarditis and postmyocarditic cardiosclerosis]. 38
21574439 2011
4
[Non-rheumatic myocarditis in practice of outpatient therapist and cardiologist]. 38
21446195 2011
5
Induction of myocarditis lesions in Lewis rats by formalin-killed cells of group A Streptococcus. 38
19215688 2009
6
[The pathologists: Aschoff, Klinge and Gräff]. 38
18309501 2008
7
Rheumatic myocarditis masquerading as left ventricle tumor. 38
16966590 2006
8
[Asymptomatic myocarditis after infection of the upper respiratory tract]. 38
15902618 2005
9
Does rheumatic myocarditis really exists? Systematic study with echocardiography and cardiac troponin I blood levels. 38
12727153 2003
10
[Extreme cardiomegaly]. 38
12219700 2002
11
Usefulness of antimyosin antibody imaging for the detection of active rheumatic myocarditis. 38
10532521 1999
12
T wave alternans and acute rheumatic myocarditis: a case report. 38
10575535 1999
13
Biventricular assist for severe acute rheumatic pancarditis. 38
8678657 1996
14
[The diagnostic significance of creatine phosphokinase antibodies in the cardiac muscle in non-coronarogenic myocardial diseases]. 38
8067013 1994
15
Does endomyocardial biopsy aid in the diagnosis of active rheumatic carditis? 38
8222115 1993
16
Evidence against a myocardial factor as the cause of left ventricular dilation in active rheumatic carditis. 38
8354818 1993
17
Triple-valve operation in the young rheumatic patient. 38
8512400 1993
18
[Sick sinus syndrome in a patient with non-rheumatic myocarditis]. 38
1791724 1991
19
[Long-term outcomes of non-rheumatic myocarditis]. 38
2678398 1989
20
[Difficulties in the differential diagnosis of non-rheumatic myocarditis]. 38
3398450 1988
21
[Diagnosis and treatment of non-rheumatic myocarditis]. 38
3381518 1988
22
Detection of acute myocarditis using nuclear magnetic resonance imaging. 38
3503583 1987
23
Cerebral infarction due to systemic necrotizing vasculitis in a patient with rheumatic heart disease, subacute bacterial endocarditis and status epilepticus. 38
2903116 1987
24
[Treatment of patients with non-rheumatic myocarditis with carbon dioxide baths]. 38
3124350 1987
25
[Several debatable questions concerning the etiology, pathogenesis and diagnosis of non-rheumatic myocarditis]. 38
3573698 1987
26
[Use of the spectrophotometric method of determining antibody-dependent cell-mediated cytotoxicity in the differential diagnosis of rheumatic and non-rheumatic myocarditis]. 38
2441127 1987
27
[Clinical variants of non-rheumatic myocarditis]. 38
3560818 1987
28
Immunofluorescence studies of florid rheumatic Aschoff lesions. 38
3513770 1986
29
[Antibodies to polysaccharides of group A Streptococcus in patients with rheumatism after mitral commissurotomy]. 38
3906993 1985
30
[Thallium myocardial scintigraphy, hemodynamics and left ventricular wall kinetics in patients with suspected myocardial sarcoidosis]. 38
2936010 1985
31
[Diagnosis and differential diagnosis of non-rheumatic myocarditis]. 38
6397818 1984
32
[Complete atrioventricular block caused by rheumatic myocarditis and complicated by a Morgagni-Adams-Stokes attack in an adult hyperthyroid patient. Discussion of a clinical case and review of the literature]. 38
6472641 1984
33
[Characteristics of immunoregulatory lymphocyte subpopulations in patients with congestive cardiomyopathy and nonrheumatic myocarditis studied by monoclonal antibodies]. 38
6151750 1984
34
Left ventricular hypertrophy in non-rheumatic myocarditis in children. 38
6215502 1982
35
[Clinico-radiographic diagnosis of acquired non-rheumatic myocarditis in children]. 38
7301502 1981
36
[Familial right bundle branch block and left axis deviation without cardiac disorders (author's transl)]. 38
6114406 1981
37
[Manifestation of the inflammatory reaction and the development of circulatory insufficiency in rheumatic myocarditis]. 38
7324421 1981
38
A case of congestive cardiomyopathy with histological findings suggesting rheumatic myocarditis by endomyocardial biopsy. 38
6448932 1980
39
Histopathological study on the conduction system of complete right bundle branch block with references to configuration of QRS complex. 38
522245 1979
40
[Clinical aspects of myocarditis--symptomatology, diagnosis and pathogenesis]. 38
399108 1979
41
[Characteristics of non-rheumatic myocarditis and its classification in children]. 38
714613 1978
42
[Differential diagnosis between infections, allergic and rheumatic myocarditis]. 38
644932 1978
43
Active valvulitis associated with chronic rheumatic valvular disease and active myocarditis. 38
618387 1978
44
[Electrocardiogram in non-rheumatic myocarditis]. 38
917900 1977
45
Streptococcal-induced cell-mediated-immune destruction of cardiac myofibers in vitro. 38
327015 1977
46
[Case of cure of complete atrioventricular block in rheumatic myocarditis]. 38
1022008 1976
47
Changes in blood-serum enzymes in rheumatic myocarditis. 38
1022412 1976
48
[Pathomorphology of the lymphatic system of the heart in rheumatism (new theories on the role of lymphogenic link in the morphogenesis of rheumatic myocarditis)]. 38
982935 1976
49
[Syncopal convulsions with myocarditis in childhood. A case contribution to the transitory pacemaker treatment of myocarditis-induced heart block]. 38
1186566 1975
50
[Aneurysm of the left ventricle associated with inactive rheumatic heart disease. Report of a case]. 38
1156009 1975
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Variations for Rheumatic Myocarditis

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Expression for Rheumatic Myocarditis

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Search GEO for disease gene expression data for Rheumatic Myocarditis.
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Pathways for Rheumatic Myocarditis

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Pathways related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 13.2 POMC IL1A GSN FCGR3B FCGR3A CRP
2
Toxoplasmosis 37
Show member pathways
 11.85 IL1A FCGR3B FCGR3A
3
Tuberculosis 37
11.8 IL1A FCGR3B FCGR3A
4
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 66
11.63 FCGR3A CD8A CD19
5
Osteoclast differentiation 37
11.54 IL1A FCGR3B FCGR3A
6
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.4 CD8A CD2 CD19
7
Primary immunodeficiency 37
11.02 CD8A CD19
8
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.91 POMC CRP
9
Hematopoietic cell lineage 37
10.91 IL1A CD8A CD2 CD19
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GO Terms for Rheumatic Myocarditis

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Cellular components related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 FCGR3A CD8A CD2 CD19

Biological processes related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.32 CD8A CD2
2 T cell activation GO:0042110 9.26 CD8A CD2
3 positive regulation of protein secretion GO:0050714 9.16 IL1A ARF1
4 regulation of immune response GO:0050776 9.13 FCGR3A CD8A CD19
5 immune response GO:0006955 8.92 IL1A FCGR3B FCGR3A CD8A

Molecular functions related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 IgG binding GO:0019864 8.62 FCGR3B FCGR3A
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Sources for Rheumatic Myocarditis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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