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MCID: RHM008
MIFTS: 36

Rheumatic Myocarditis

Categories: Bone diseases, Cardiovascular diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Rheumatic Myocarditis

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MalaCards integrated aliases for Rheumatic Myocarditis:

Name: Rheumatic Myocarditis 12 15 32
Acute Rheumatic Myocarditis 12 71 32
Active Rheumatic Fever with Myocarditis 12
Rheumatic Degeneration of Myocardium 12
Rheumatic Fever with Myocarditis 12
Acute Rheumatic Heart Disease 71
Acute Rheumatic Carditis 12
Rheumatoid Myocarditis 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Cardiovascular diseases Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:8481
ICD9CM 34 391.9 398.0
NCIt 49 C34985
SNOMED-CT 67 4536006 8805001
UMLS 71 C0035440 C0155557 C0489959
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Summaries for Rheumatic Myocarditis

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MalaCards based summary : Rheumatic Myocarditis, also known as acute rheumatic myocarditis, is related to mitral valve insufficiency and cardiac tamponade. An important gene associated with Rheumatic Myocarditis is TNNI3 (Troponin I3, Cardiac Type), and among its related pathways/superpathways are Cytoskeletal Signaling and Striated Muscle Contraction. The drugs Abatacept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and bone.

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Related Diseases for Rheumatic Myocarditis

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Diseases related to Rheumatic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 mitral valve insufficiency 30.5 TNNT2 TNNI3 CRP
2 cardiac tamponade 30.4 TNNI3 CRP
3 pharyngitis 30.2 MYOM2 CRP
4 heart septal defect 30.2 TNNT2 TNNI3
5 acute myocarditis 30.1 TNNI3 CRP
6 pericardial effusion 30.0 TNNI3 CRP
7 pericarditis 30.0 TNNT2 TNNI3 CRP
8 aortic valve insufficiency 30.0 MIR374B CRP
9 congestive heart failure 29.5 TNNT2 TNNI3 CRP
10 heart valve disease 28.6 TNNT2 TNNI3 MYOM2 MIR374B CRP
11 rheumatic fever-related antigen 10.9
12 myocarditis 10.8
13 gastric dilatation 10.3 TNNI3 CRP
14 constrictive pericarditis 10.3 TNNI3 CRP
15 volvulus of midgut 10.3 TNNI3 CRP
16 coronary artery vasospasm 10.3 TNNI3 CRP
17 orthostatic intolerance 10.3
18 acute poststreptococcal glomerulonephritis 10.3
19 glomerulonephritis 10.3
20 tricuspid valve insufficiency 10.3 TNNI3 CRP
21 tricuspid valve disease 10.2 TNNI3 CRP
22 ecthyma 10.2 MYOM2 CRP
23 mononeuritis of upper limb and mononeuritis multiplex 10.2 MYOM2 CRP
24 mononeuritis multiplex 10.2 MYOM2 CRP
25 scarlet fever 10.2 MYOM2 CRP
26 polyclonal hypergammaglobulinemia 10.2 MYOM2 CRP
27 mononeuropathy 10.2 MYOM2 CRP
28 angina pectoris 10.2 TNNI3 CRP
29 papilledema 10.2 MYOM2 CRP
30 erysipelas 10.2 MYOM2 CRP
31 endocarditis 10.2
32 purpura 10.2
33 aortic valve prolapse 10.2
34 necrotizing fasciitis 10.2 MYOM2 CRP
35 atrioventricular block 10.2
36 rheumatic fever 10.2
37 plasma protein metabolism disease 10.2 MYOM2 CRP
38 asymmetric motor neuropathy 10.1 MYOM2 GSN
39 familial isolated restrictive cardiomyopathy 10.1 TNNT2 TNNI3
40 pyoderma 10.1 MYOM2 CRP
41 nerve compression syndrome 10.1 GSN CRP
42 mitral valve disease 10.1 TNNI3 CRP
43 rheumatic disease 10.1
44 enthesopathy 10.1
45 mineral metabolism disease 10.1 MYOM2 CRP
46 myocardial stunning 10.0 TNNT2 TNNI3
47 commensal bacterial infectious disease 10.0 MYOM2 CRP
48 coronary stenosis 10.0 TNNI3 CRP
49 cardiac conduction defect 10.0
50 cd4/cd8 t-cell ratio 10.0

Comorbidity relations with Rheumatic Myocarditis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Mitral Valve Disease Mitral Valve Stenosis
Rheumatic Heart Disease

Graphical network of the top 20 diseases related to Rheumatic Myocarditis:



Diseases related to Rheumatic Myocarditis
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Symptoms & Phenotypes for Rheumatic Myocarditis

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Drugs & Therapeutics for Rheumatic Myocarditis

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Drugs for Rheumatic Myocarditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4 332348-12-6 10237
2
Adalimumab Approved Phase 4 331731-18-1 16219006
3 Anti-Inflammatory Agents Phase 4
4 Antirheumatic Agents Phase 4
5 Immunosuppressive Agents Phase 4
6 Immunologic Factors Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Abatacept on Myocarditis in Rheumatoid Arthritis Recruiting NCT03619876 Phase 4 Abatacept;Adalimumab

Search NIH Clinical Center for Rheumatic Myocarditis

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Genetic Tests for Rheumatic Myocarditis

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Anatomical Context for Rheumatic Myocarditis

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MalaCards organs/tissues related to Rheumatic Myocarditis:

40
Heart, Testes, Bone, Kidney, T Cells
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Publications for Rheumatic Myocarditis

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Articles related to Rheumatic Myocarditis:

(show top 50) (show all 93)
# Title Authors PMID Year
1
Heart Transplant in Patients with Predominantly Rheumatic Valvular Heart Disease. 61
26897843 2015
2
Incidental histological diagnosis of acute rheumatic myocarditis: case report and review of the literature. 61
25478552 2014
3
[Radionuclide methods for diagnostics of non-rheumatic myocarditis and postmyocarditic cardiosclerosis]. 61
21574439 2011
4
[Non-rheumatic myocarditis in practice of outpatient therapist and cardiologist]. 61
21446195 2011
5
Induction of myocarditis lesions in Lewis rats by formalin-killed cells of group A Streptococcus. 61
19215688 2009
6
[The pathologists: Aschoff, Klinge and Gräff]. 61
18309501 2008
7
Rheumatic myocarditis masquerading as left ventricle tumor. 61
16966590 2006
8
[Asymptomatic myocarditis after infection of the upper respiratory tract]. 61
15902618 2005
9
Does rheumatic myocarditis really exists? Systematic study with echocardiography and cardiac troponin I blood levels. 61
12727153 2003
10
[Extreme cardiomegaly]. 61
12219700 2002
11
Usefulness of antimyosin antibody imaging for the detection of active rheumatic myocarditis. 61
10532521 1999
12
T wave alternans and acute rheumatic myocarditis: a case report. 61
10575535 1999
13
Biventricular assist for severe acute rheumatic pancarditis. 61
8678657 1996
14
[The diagnostic significance of creatine phosphokinase antibodies in the cardiac muscle in non-coronarogenic myocardial diseases]. 61
8067013 1994
15
Does endomyocardial biopsy aid in the diagnosis of active rheumatic carditis? 61
8222115 1993
16
Evidence against a myocardial factor as the cause of left ventricular dilation in active rheumatic carditis. 61
8354818 1993
17
Triple-valve operation in the young rheumatic patient. 61
8512400 1993
18
[Sick sinus syndrome in a patient with non-rheumatic myocarditis]. 61
1791724 1991
19
[Long-term outcomes of non-rheumatic myocarditis]. 61
2678398 1989
20
[Difficulties in the differential diagnosis of non-rheumatic myocarditis]. 61
3398450 1988
21
[Diagnosis and treatment of non-rheumatic myocarditis]. 61
3381518 1988
22
Detection of acute myocarditis using nuclear magnetic resonance imaging. 61
3503583 1987
23
Cerebral infarction due to systemic necrotizing vasculitis in a patient with rheumatic heart disease, subacute bacterial endocarditis and status epilepticus. 61
2903116 1987
24
[Treatment of patients with non-rheumatic myocarditis with carbon dioxide baths]. 61
3124350 1987
25
[Several debatable questions concerning the etiology, pathogenesis and diagnosis of non-rheumatic myocarditis]. 61
3573698 1987
26
[Use of the spectrophotometric method of determining antibody-dependent cell-mediated cytotoxicity in the differential diagnosis of rheumatic and non-rheumatic myocarditis]. 61
2441127 1987
27
[Clinical variants of non-rheumatic myocarditis]. 61
3560818 1987
28
Immunofluorescence studies of florid rheumatic Aschoff lesions. 61
3513770 1986
29
[Antibodies to polysaccharides of group A Streptococcus in patients with rheumatism after mitral commissurotomy]. 61
3906993 1985
30
[Thallium myocardial scintigraphy, hemodynamics and left ventricular wall kinetics in patients with suspected myocardial sarcoidosis]. 61
2936010 1985
31
[Diagnosis and differential diagnosis of non-rheumatic myocarditis]. 61
6397818 1984
32
[Complete atrioventricular block caused by rheumatic myocarditis and complicated by a Morgagni-Adams-Stokes attack in an adult hyperthyroid patient. Discussion of a clinical case and review of the literature]. 61
6472641 1984
33
[Characteristics of immunoregulatory lymphocyte subpopulations in patients with congestive cardiomyopathy and nonrheumatic myocarditis studied by monoclonal antibodies]. 61
6151750 1984
34
Left ventricular hypertrophy in non-rheumatic myocarditis in children. 61
6215502 1982
35
[Clinico-radiographic diagnosis of acquired non-rheumatic myocarditis in children]. 61
7301502 1981
36
[Familial right bundle branch block and left axis deviation without cardiac disorders (author's transl)]. 61
6114406 1981
37
[Manifestation of the inflammatory reaction and the development of circulatory insufficiency in rheumatic myocarditis]. 61
7324421 1981
38
A case of congestive cardiomyopathy with histological findings suggesting rheumatic myocarditis by endomyocardial biopsy. 61
6448932 1980
39
Histopathological study on the conduction system of complete right bundle branch block with references to configuration of QRS complex. 61
522245 1979
40
[Clinical aspects of myocarditis--symptomatology, diagnosis and pathogenesis]. 61
399108 1979
41
[Characteristics of non-rheumatic myocarditis and its classification in children]. 61
714613 1978
42
[Differential diagnosis between infections, allergic and rheumatic myocarditis]. 61
644932 1978
43
Active valvulitis associated with chronic rheumatic valvular disease and active myocarditis. 61
618387 1978
44
[Electrocardiogram in non-rheumatic myocarditis]. 61
917900 1977
45
Streptococcal-induced cell-mediated-immune destruction of cardiac myofibers in vitro. 61
327015 1977
46
[Case of cure of complete atrioventricular block in rheumatic myocarditis]. 61
1022008 1976
47
[Pathomorphology of the lymphatic system of the heart in rheumatism (new theories on the role of lymphogenic link in the morphogenesis of rheumatic myocarditis)]. 61
982935 1976
48
Changes in blood-serum enzymes in rheumatic myocarditis. 61
1022412 1976
49
[Syncopal convulsions with myocarditis in childhood. A case contribution to the transitory pacemaker treatment of myocarditis-induced heart block]. 61
1186566 1975
50
[Aneurysm of the left ventricle associated with inactive rheumatic heart disease. Report of a case]. 61
1156009 1975
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Variations for Rheumatic Myocarditis

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Expression for Rheumatic Myocarditis

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Search GEO for disease gene expression data for Rheumatic Myocarditis.
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Pathways for Rheumatic Myocarditis

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Pathways related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytoskeletal Signaling 4
11.29 TNNT2 TNNI3 GSN
2
Striated Muscle Contraction 65 1
11.01 TNNT2 TNNI3
3
Cardiac Progenitor Differentiation 1
10.68 TNNT2 TNNI3
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GO Terms for Rheumatic Myocarditis

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Cellular components related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 9.37 TNNT2 TNNI3
2 striated muscle thin filament GO:0005865 9.32 TNNT2 MYOM2
3 troponin complex GO:0005861 9.26 TNNT2 TNNI3
4 cardiac myofibril GO:0097512 9.16 TNNT2 TNNI3
5 cardiac Troponin complex GO:1990584 8.96 TNNT2 TNNI3
6 sarcomere GO:0030017 8.92 TNNT2 TNNI3 MYOM2 ARF1

Biological processes related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cardiac muscle contraction GO:0060048 9.43 TNNT2 TNNI3
2 sarcomere organization GO:0045214 9.4 TNNT2 MYOM2
3 muscle filament sliding GO:0030049 9.37 TNNT2 TNNI3
4 skeletal muscle contraction GO:0003009 9.32 TNNT2 TNNI3
5 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.26 TNNT2 TNNI3
6 regulation of muscle contraction GO:0006937 9.16 TNNT2 TNNI3
7 negative regulation of ATPase activity GO:0032780 8.96 TNNT2 TNNI3
8 muscle contraction GO:0006936 8.8 TNNT2 TNNI3 MYOM2

Molecular functions related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.33 TNNT2 TNNI3 GSN
2 actin filament binding GO:0051015 9.13 TNNI3 MYOM2 GSN
3 troponin C binding GO:0030172 8.62 TNNT2 TNNI3
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Sources for Rheumatic Myocarditis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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