MCID: RHM008
MIFTS: 34

Rheumatic Myocarditis

Categories: Bone diseases, Cardiovascular diseases, Infectious diseases
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Aliases & Classifications for Rheumatic Myocarditis

MalaCards integrated aliases for Rheumatic Myocarditis:

Name: Rheumatic Myocarditis 11 14 31 33
Acute Rheumatic Myocarditis 11 71 31 33
Active Rheumatic Fever with Myocarditis 11 33
Inactive or Quiescent Rheumatic Fever with Myocarditis 33
Acute or Subacute Rheumatic Myocardial Insufficiency 33
Myocardial Insufficiency with Rheumatic Fever 33
Dilated Cardiomyopathy Due to Rheumatic Fever 33
Myocardial Degeneration with Rheumatic Fever 33
Active Rheumatic Interstitial Myocarditis 33
Active Rheumatic Progressive Myocarditis 33
Acute Rheumatic Fever with Myocarditis 33
Active or Acute Rheumatic Myocarditis 33
Rheumatic Degeneration of Myocardium 11
Chronic Active Rheumatic Myocarditis 33
Active Rheumatic Fibroid Myocarditis 33
Rheumatic Interstitial Myocarditis 33
Myocarditis Due to Rheumatic Fever 33
Rheumatic Myocardial Insufficiency 33
Acute Rheumatic Toxic Myocarditis 33
Rheumatic Progressive Myocarditis 33
Rheumatic Fever with Myocarditis 11
Old Active Rheumatic Myocarditis 33
Inactive Rheumatic Myocarditis 33
Acute Rheumatic Heart Disease 71
Rheumatic Fibroid Myocarditis 33
Active Rheumatic Myocarditis 33
Acute Rheumatic Carditis 11
Rheumatic Cardiomyopathy 33
Rheumatoid Myocarditis 11

Classifications:



External Ids:

Disease Ontology 11 DOID:8481
ICD9CM 34 391.9 398.0
NCIt 49 C34985
SNOMED-CT 68 195136004 8805001
UMLS 71 C0035440 C0155557 C0489959

Summaries for Rheumatic Myocarditis

MalaCards based summary: Rheumatic Myocarditis, also known as acute rheumatic myocarditis, is related to myocarditis and mitral valve insufficiency. An important gene associated with Rheumatic Myocarditis is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Cytoskeletal Signaling and Cardiac progenitor differentiation. Affiliated tissues include heart, neutrophil and brain.

Related Diseases for Rheumatic Myocarditis

Diseases related to Rheumatic Myocarditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 myocarditis 30.9 TNNT2 TNNI3 MB
2 mitral valve insufficiency 30.7 TNNT2 TNNI3 CRP
3 acute poststreptococcal glomerulonephritis 30.7 MYOM2 CRP
4 pharyngitis 30.4 MYOM2 CRP
5 cardiac tamponade 30.3 TNNI3 CRP
6 pericarditis 30.2 TNNT2 TNNI3 CRP
7 heart septal defect 30.2 TNNT2 CRP
8 atrioventricular block 30.1 TNNT2 TNNI3 CRP
9 third-degree atrioventricular block 30.1 TNNI3 CRP
10 endocarditis 30.0 TNNT2 TNNI3 CRP
11 acute myocarditis 29.7 TNNT2 TNNI3 CRP
12 aortic valve insufficiency 29.7 TNNI3 MIR374B CRP
13 hypertrophic cardiomyopathy 29.4 TNNT2 TNNI3 MYOM2 CRP
14 heart valve disease 29.3 TNNT2 TNNI3 MYOM2 MIR374B CRP
15 pericardial effusion 29.2 TNNT2 TNNI3 MB CRP
16 dilated cardiomyopathy 29.0 TNNT2 TNNI3 MYOM2 MB CRP
17 rheumatic fever 10.5
18 orthostatic intolerance 10.3
19 glomerulonephritis 10.3
20 rheumatic heart disease 10.2
21 henoch-schoenlein purpura 10.2
22 choreatic disease 10.2
23 purpura 10.2
24 aortic valve prolapse 10.2
25 streptococcal meningitis 10.2 MYOM2 CRP
26 gastric dilatation 10.2 TNNI3 CRP
27 mononeuritis of upper limb and mononeuritis multiplex 10.2 MYOM2 CRP
28 hemopericardium 10.2 TNNI3 CRP
29 lethal congenital contracture syndrome 4 10.2 TNNI3 MYOM2
30 acute cor pulmonale 10.2 TNNI3 CRP
31 scarlet fever 10.2 MYOM2 CRP
32 acute pulmonary heart disease 10.2 TNNI3 CRP
33 first-degree atrioventricular block 10.2 TNNI3 CRP
34 multicentric castleman disease 10.2 MYOM2 CRP
35 castleman disease 10.2 MYOM2 CRP
36 heart cancer 10.2 TNNI3 CRP
37 necrotizing fasciitis 10.2 MYOM2 CRP
38 non-severe covid-19 10.2 TNNI3 CRP
39 erysipelas 10.1 MYOM2 CRP
40 septic arthritis 10.1 MYOM2 CRP
41 papilledema 10.1 MYOM2 CRP
42 familial isolated restrictive cardiomyopathy 10.1 TNNT2 TNNI3
43 demyelinating polyneuropathy 10.1 MYOM2 CRP
44 coronary thrombosis 10.1 TNNI3 CRP
45 inferior myocardial infarction 10.1 TNNT2 TNNI3
46 cellulitis 10.1 MYOM2 CRP
47 plasma protein metabolism disease 10.1 MYOM2 CRP
48 nerve compression syndrome 10.1 GSN CRP
49 pyoderma 10.1 MYOM2 CRP
50 cardiomyopathy, dilated, 1b 10.1 TNNT2 TNNI3

Comorbidity relations with Rheumatic Myocarditis via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Mitral Valve Disease Mitral Valve Stenosis
Rheumatic Heart Disease

Graphical network of the top 20 diseases related to Rheumatic Myocarditis:



Diseases related to Rheumatic Myocarditis

Symptoms & Phenotypes for Rheumatic Myocarditis

Drugs & Therapeutics for Rheumatic Myocarditis

Search Clinical Trials, NIH Clinical Center for Rheumatic Myocarditis

Genetic Tests for Rheumatic Myocarditis

Anatomical Context for Rheumatic Myocarditis

Organs/tissues related to Rheumatic Myocarditis:

MalaCards : Heart, Neutrophil, Brain, Pituitary

Publications for Rheumatic Myocarditis

Articles related to Rheumatic Myocarditis:

(show top 50) (show all 218)
# Title Authors PMID Year
1
Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study. 62
34419237 2021
2
An evidence-based scoring system to diagnose acute rheumatic fever with carditis in children. 62
33667575 2021
3
Cardiac Immunology: A New Era for Immune Cells in the Heart. 62
32910424 2021
4
Rheumatic Myocarditis: A Poorly Recognized Etiology of Left Ventricular Dysfunction in Valvular Heart Disease Patients. 62
34179142 2021
5
Characteristics of Children with Acute Rheumatic Carditis from a High-Incidence Region: Importance of Unexplained Worsening of Functional Class. 62
32526745 2020
6
Evaluation of ventricular arrhythmogenesis in children with acute rheumatic carditis. 62
30160770 2018
7
The neutrophil-to-lymphocyte ratio and mean platelet volume can be associated with severity of valvular involvement in patients with acute rheumatic carditis. 62
30198547 2018
8
Systolic aortic regurgitation in rheumatic carditis: Mechanistic insight by Doppler echocardiography. 62
29716706 2018
9
Henoch-Schonlein purpura, post-streptococcal glomerulonephritis and acute rheumatic carditis after Group A β-haemolytic streptococcal infection. 62
28162051 2018
10
Acute rheumatic fever presenting as complete heart block: report of an adolescent case and review of literature. 62
29440244 2018
11
A rare situation in acute rheumatic carditis: Involvement of all four valves. 62
29624235 2017
12
Parameters indicative of persistence of valvular pathology at initial diagnosis in acute rheumatic carditis: the role of albumin and CD19 expression. 62
27553592 2016
13
Red blood cell distribution width: can it be a predictive marker for long-term valvular involvement in children with acute rheumatic carditis? 62
27435353 2016
14
Acute Rheumatic Carditis: A Rare Cause for Reversible Complete Heart Block. 62
26535164 2015
15
Plasma gelsolin as a biomarker of acute rheumatic carditis. 62
25403731 2015
16
Heart Transplant in Patients with Predominantly Rheumatic Valvular Heart Disease. 62
26897843 2015
17
Heart lesion after the first attack of the rheumatic Fever 22 years experience in single centre. 62
25870479 2015
18
The role of 18F fluorodeoxyglucose positron emission tomography (18F-FDG-PET) in children with rheumatic carditis and chronic rheumatic heart disease. 62
25633513 2015
19
Importance of N-terminal pro-brain natriuretic peptide in monitoring acute rheumatic carditis. 62
24161016 2015
20
Are mean platelet volume and platelet distribution width useful parameters in children with acute rheumatic carditis? 62
23780555 2014
21
Incidental histological diagnosis of acute rheumatic myocarditis: case report and review of the literature. 62
25478552 2014
22
Association of heart block with uncommon disease States. 62
24436606 2013
23
[Acute rheumatic carditis in Ivory Coast: changes in prevalence during the decade 2000-2009]. 62
22560250 2013
24
N-Terminal proBNP Levels and Tissue Doppler Echocardiography in Acute Rheumatic Carditis. 62
24109516 2013
25
Adams-Stokes attack as the first symptom of acute rheumatic fever: report of an adolescent case and review of the literature. 62
23110777 2012
26
Diagnosis of acute rheumatic carditis: An echo in time…. 62
23129898 2012
27
Antistreptolysin O titer in health and disease: levels and significance. 62
22690314 2012
28
Ongoing inflammation in children with rheumatic heart disease. 62
21303581 2011
29
A dramatic decline in university hospital admissions of acute rheumatic fever in the eastern region of Saudi Arabia. 62
23960643 2011
30
Cardiac troponin T in children with acute rheumatic carditis. 62
20957477 2011
31
[Radionuclide methods for diagnostics of non-rheumatic myocarditis and postmyocarditic cardiosclerosis]. 62
21574439 2011
32
[Non-rheumatic myocarditis in practice of outpatient therapist and cardiologist]. 62
21446195 2011
33
The role of viral agents in aetiopathogenesis of acute rheumatic fever. 62
20401762 2011
34
Aortic valve repair by cusp extension for rheumatic aortic insufficiency in children: Long-term results and impact of extension material. 62
20659746 2010
35
QT Dispersion predicting acute rheumatic carditis. 62
20557664 2010
36
Acute rheumatic carditis associated with Schoenlein-Henoch vasculitis. 62
20929708 2010
37
Release of N-terminal pro-brain natriuretic peptide in children with acute rheumatic carditis. 62
20416140 2010
38
Induction of myocarditis lesions in Lewis rats by formalin-killed cells of group A Streptococcus. 62
19215688 2009
39
[The pathologists: Aschoff, Klinge and Gräff]. 62
18309501 2008
40
Assessment of myocardial involvement using cardiac troponin-I and echocardiography in rheumatic carditis in Izmir, Turkey. 62
18279207 2008
41
The prolongation of the QT interval in the acute rheumatic carditis: an enigma. 62
17262097 2006
42
Rheumatic myocarditis masquerading as left ventricle tumor. 62
16966590 2006
43
QT dispersion in acute rheumatic fever. 62
16553975 2006
44
[Asymptomatic myocarditis after infection of the upper respiratory tract]. 62
15902618 2005
45
Henoch schonlein purpura with rheumatic carditis. 62
15107527 2004
46
Flail posterior leaflet of the mitral valve in acute rheumatic carditis. 62
15039879 2004
47
Treatment of acute rheumatic carditis with choline magnesium trisalicylate in a patient needing surgery. 62
23118684 2003
48
Does rheumatic myocarditis really exists? Systematic study with echocardiography and cardiac troponin I blood levels. 62
12727153 2003
49
Is pentoxifylline therapy effective for the treatment of acute rheumatic carditis? A pilot study. 62
12654146 2003
50
Evidence for lack of myocardial injury in children with acute rheumatic carditis. 62
12635999 2002

Variations for Rheumatic Myocarditis

Expression for Rheumatic Myocarditis

Search GEO for disease gene expression data for Rheumatic Myocarditis.

Pathways for Rheumatic Myocarditis

Pathways related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 TNNT2 TNNI3 GSN
2 10.68 TNNT2 TNNI3

GO Terms for Rheumatic Myocarditis

Cellular components related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin complex GO:0005861 9.46 TNNT2 TNNI3
2 cardiac myofibril GO:0097512 9.26 TNNT2 TNNI3
3 cardiac Troponin complex GO:1990584 8.92 TNNT2 TNNI3

Biological processes related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.56 TNNT2 TNNI3
2 negative regulation of ATP-dependent activity GO:0032780 9.26 TNNT2 TNNI3
3 regulation of muscle contraction GO:0006937 9.16 TNNT2 TNNI3
4 muscle contraction GO:0006936 9.02 TNNT2 TNNI3 MYOM2

Molecular functions related to Rheumatic Myocarditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin C binding GO:0030172 8.92 TNNT2 TNNI3

Sources for Rheumatic Myocarditis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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