RA
MCID: RHM011
MIFTS: 82

Rheumatoid Arthritis (RA)

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Arthritis

MalaCards integrated aliases for Rheumatoid Arthritis:

Name: Rheumatoid Arthritis 57 38 12 76 25 75 37 29 55 6 43 3 15 63 73
Ra 57 25 75 3
Arthritis, Rheumatoid 25 44 40
Rheumatoid Arthritis, Susceptibility to 57
Arthritis or Polyarthritis, Rheumatic 12
Atrophic Arthritis 12

Characteristics:

OMIM:

57
Inheritance:
unproved inheritance


Classifications:



External Ids:

OMIM 57 180300
Disease Ontology 12 DOID:7148
ICD9CM 35 714.0
MeSH 44 D001172
NCIt 50 C2884
SNOMED-CT 68 69896004
MedGen 42 C0003873
KEGG 37 H00630
UMLS 73 C0003873

Summaries for Rheumatoid Arthritis

MedlinePlus : 43 Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. It can affect any joint but is common in the wrist and fingers. More women than men get rheumatoid arthritis. It often starts in middle age and is most common in older people. You might have the disease for only a short time, or symptoms might come and go. The severe form can last a lifetime. Rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. RA can affect body parts besides joints, such as your eyes, mouth and lungs. RA is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. No one knows what causes rheumatoid arthritis. Genes, environment, and hormones might contribute. Treatments include medicine, lifestyle changes, and surgery. These can slow or stop joint damage and reduce pain and swelling. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Rheumatoid arthritis and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Adalimumab and Abatacept have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, bone and t cells, and related phenotypes are abnormality of the immune system and abnormality of the nervous system

Disease Ontology : 12 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

Genetics Home Reference : 25 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

OMIM : 57 Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. (180300)

UniProtKB/Swiss-Prot : 75 Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

PubMed Health : 63 About rheumatoid arthritis: There are many different rheumatic diseases, but rheumatoid arthritis is probably the most common. In rheumatoid arthritis, people usually have several permanently inflamed joints. This causes the joints to gradually become deformed and stiff. Over time the muscles also weaken.Someone with advanced rheumatoid arthritis may have difficulties with simple tasks such as washing themselves, eating with a knife and fork, or buttoning up a shirt. Other symptoms such as pain and fatigue can be very troublesome too. This disease can also affect other parts of the body, like the blood vessels or certain organs.Rheumatoid arthritis usually gradually worsens over the course of many years. Various treatments can relieve the pain and slow the progression of the disease. Early diagnosis and treatment can help to prevent damage to the joints.

Wikipedia : 76 Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It... more...

Related Diseases for Rheumatoid Arthritis

Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1333)
# Related Disease Score Top Affiliating Genes
1 arthritis 33.9 PTPN22 IL6 IL10 CIITA
2 psoriatic arthritis 31.5 PTPN22 MIR146A IL6
3 autoimmune disease 31.4 PTPN22 PADI4 IL6 IL10 CIITA
4 bone inflammation disease 30.9 PTPN22 PADI4 IL6 IL10
5 polymyositis 30.7 MIR155 MIR132
6 toxic shock syndrome 30.7 IL6 IL10 CIITA
7 anterior uveitis 30.6 PTPN22 IL6
8 ulcerative colitis 30.5 IL6 IL10 H19
9 celiac disease 1 30.4 PTPN22 IL10 CIITA
10 pancreatic ductal adenocarcinoma 30.3 UCA1 MIR155 MIR150 MIR146A MALAT1 HOTAIR
11 diabetes mellitus 30.3 PTPN22 MIR155 MIR132 MALAT1 IL6
12 pancreatic cancer 30.1 UCA1 MIR155 MIR146A MALAT1 HOTAIR H19
13 diffuse large b-cell lymphoma 30.0 MIR155 MIR150 HOTAIR
14 myeloma, multiple 29.9 UCA1 MALAT1 IL6 HOTAIR H19
15 thyroid cancer, nonmedullary, 1 29.8 MIR155 MIR146A MALAT1 HOTAIR H19
16 colorectal cancer 29.8 ZFAS1 UCA1 MIR155 MIR132 MALAT1 IL6
17 cholangiocarcinoma 29.7 UCA1 MALAT1 IL6 H19
18 endometriosis 29.7 MIR150 IL6 H19
19 gallbladder cancer 29.7 UCA1 MALAT1 HOTAIR H19
20 kidney cancer 29.6 MIR150 MALAT1 HOTAIR H19
21 esophageal cancer 29.6 UCA1 MALAT1 IL6 HOTAIR H19
22 laryngeal squamous cell carcinoma 29.5 MALAT1 HOTAIR H19
23 glioma 29.5 ZFAS1 UCA1 MALAT1 HOTAIR H19
24 oral squamous cell carcinoma 29.4 UCA1 MIR155 MIR146A MALAT1 HOTAIR H19
25 renal cell carcinoma, nonpapillary 29.4 UCA1 MALAT1 HOTAIR H19
26 pituitary adenoma 29.2 MIR132 MALAT1 HOTAIR H19
27 ovarian epithelial cancer 29.2 MALAT1 HOTAIR H19
28 osteogenic sarcoma 29.1 UCA1 MALAT1 HOTAIR H19
29 leukemia, acute myeloid 29.1 UCA1 MIR155 MIR146A MALAT1 HOTAIR
30 adamantinoma of long bones 29.0 ZFAS1 UCA1 MALAT1 HOTAIR H19
31 bladder cancer 29.0 ZFAS1 UCA1 MALAT1 HOTAIR H19
32 gastric cancer 28.9 ZFAS1 UCA1 MIR150 MALAT1 HOTAIR H19
33 lung cancer 28.7 ZFAS1 UCA1 MIR155 MIR150 MIR146A MALAT1
34 hepatocellular carcinoma 28.6 ZFAS1 UCA1 MIR155 MIR150 MIR146A MIR132
35 ovarian cancer 28.5 ZFAS1 UCA1 MIR155 MIR150 MIR146A MALAT1
36 juvenile rheumatoid arthritis 12.9
37 rheumatoid arthritis, systemic juvenile 12.7
38 ras-associated autoimmune leukoproliferative disorder 12.6
39 felty syndrome 12.4
40 rheumatoid lung disease 11.8
41 polyarticular onset juvenile idiopathic arthritis 11.8
42 adult-onset still's disease 11.7
43 rheumatoid vasculitis 11.7
44 carpal tunnel syndrome 11.7
45 sjogren syndrome 11.6
46 systemic onset juvenile idiopathic arthritis 11.6
47 palindromic rheumatism 11.6
48 caplan's syndrome 11.6
49 spondyloarthropathy 1 11.6
50 interstitial lung disease 11.6

Comorbidity relations with Rheumatoid Arthritis via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Bronchiectasis Bronchitis
Chronic Rheumatic Pericarditis Conn's Syndrome
Decubitus Ulcer Deficiency Anemia
Esophagitis Felty Syndrome
Heart Disease Hypersensitivity Vasculitis
Hypertension, Essential Hypothyroidism
Idiopathic Interstitial Pneumonia Immune Deficiency Disease
Iron Deficiency Anemia Mononeuropathy of the Median Nerve, Mild
Neutropenia Olecranon Bursitis
Oral Candidiasis Osteoarthritis
Osteoporosis Perforated Corneal Ulcer
Postinflammatory Pulmonary Fibrosis Premature Ovarian Failure 7
Protein-Energy Malnutrition Rheumatoid Lung Disease
Scleritis Sjogren Syndrome
Spondyloarthropathy 1 Systemic Lupus Erythematosus
Temporal Arteritis

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to Rheumatoid Arthritis

Symptoms & Phenotypes for Rheumatoid Arthritis

Symptoms via clinical synopsis from OMIM:

57
Joints:
rheumatoid arthritis

Limbs:
rheumatoid nodules

Vascular:
rheumatoid vasculitis

Neuro:
rheumatoid vasculitic mononeuritis

Immunology:
hla-drb1 association

Pulm:
rheumatoid lung disease

Heme:
felty syndrome


Clinical features from OMIM:

180300

Human phenotypes related to Rheumatoid Arthritis:

32 (show all 6)
# Description HPO Frequency HPO Source Accession
1 abnormality of the immune system 32 HP:0002715
2 abnormality of the nervous system 32 HP:0000707
3 vasculitis 32 HP:0002633
4 abnormality of blood and blood-forming tissues 32 HP:0001871
5 abnormality of the respiratory system 32 HP:0002086
6 rheumatoid arthritis 32 HP:0001370

UMLS symptoms related to Rheumatoid Arthritis:


back pain, sciatica, muscle cramp

Drugs & Therapeutics for Rheumatoid Arthritis

PubMedHealth treatment related to Rheumatoid Arthritis: 63

Rheumatoid arthritis is treated with both medication and non-drug approaches, such as physiotherapy. There are also various support aids available for making everyday tasks easier. Which of these treatments are suitable options will depend on, for example, how severe the inflammation and the symptoms are, how advanced the disease is, the expected progression of the disease – and how well previous treatments have worked.Medication canreduce inflammation and help keep the disease from getting worse,relieve symptoms like pain and swelling, andhelp people move their joints more easily again, or at least maintain joint flexibility for as long as possible.There is currently no cure for rheumatoid arthritis.Physiotherapy and sports can help improve or maintain flexibility, strength and joint function. Many types of sports are suitable for people who have rheumatoid arthritis, including cycling, brisk walking, dancing, aerobics, strength training, swimming and water aerobics. Occupational therapy can be used to maintain your flexibility and hand strength, and to learn how to cope with rheumatoid arthritis in everyday life.Psychological treatments are also sometimes used to help relieve pain and minimize the impact it has on everyday life. They are also intended to help relieve disease-related anxiety and depression that some people develop.Support aids are designed to help compensate for physical limitations and help with daily activities. These include orthopedic shoe inserts, grabbing aids and specially designed cutlery.

Drugs for Rheumatoid Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 607)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
2
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 332348-12-6 10237
3
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 174722-31-7 10201696
4
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
5
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 59-05-2, 1959-05-2 126941
7
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
8
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 599-79-1 5353980 5359476
9
Hydroxychloroquine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 118-42-3 3652
10
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 2 16590-41-3 5360515
11
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
12
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
13
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
14
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
15
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
16
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
17
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
18
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
19
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 104987-11-3 445643 439492
20
Entecavir Approved, Investigational Phase 4,Phase 3,Not Applicable 142217-69-4 153941
21
Zinc Approved, Investigational Phase 4,Not Applicable 7440-66-6
22
Dimethyl fumarate Approved, Investigational Phase 4,Phase 2 624-49-7 637568 5271565
23
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
24
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 4594 9579578
25
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
26
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
27
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
28
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
29
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
30
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 46835353 6436030 5284616
31
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22916-47-8 4189
32
chloroquine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 54-05-7 2719
33
Tofacitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 477600-75-2
34
Aspirin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-78-2 2244
35
Ethanol Approved Phase 4,Phase 2 64-17-5 702
36
Azathioprine Approved Phase 4,Phase 3 446-86-6 2265
37 tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable
38
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
39
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 124-94-7 31307
40
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
41
Minocycline Approved, Investigational Phase 4,Phase 3 10118-90-8 5281021
42
Norepinephrine Approved Phase 4 51-41-2 439260
43
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
44
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
45
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
46
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
47
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
48
Promethazine Approved, Investigational Phase 4 60-87-7 4927
49
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 51-45-6, 75614-87-8 774
50
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100

Interventional clinical trials:

(show top 50) (show all 2579)
# Name Status NCT ID Phase Drugs
1 Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis Unknown status NCT01000441 Phase 4 infliximab, etanercept, adalimumab;abatacept, rituximab or tocilizumab
2 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
3 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
4 Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT01548001 Phase 4 Iguratimod;Methotrexate
5 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
6 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
7 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
8 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
9 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
10 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
11 REstore Working Ability in RheumatoiD Arthritis Unknown status NCT01405326 Phase 4
12 Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Unknown status NCT01067430 Phase 4 Etoricoxib;Diclofenac
13 Rheumatoid Arthritis Patients in Training Unknown status NCT00434200 Phase 4
14 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
15 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
16 Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis Unknown status NCT00216177 Phase 4 Infliximab;Adalimumab
17 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
18 Inhibition of Co-Stimulation in Rheumatoid Arthritis Unknown status NCT02652273 Phase 4 Abatacept
19 Bucillamine Study of Holding Remission After Infliximab Dose-off Unknown status NCT00716248 Phase 4 bucillamine;methotrexate
20 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
21 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
22 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
23 The Clinical Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months Treatment Unknown status NCT02837978 Phase 4 Tacrolimus;MTX
24 Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate Unknown status NCT01270035 Phase 4 Adalimumab
25 Etanercept and Methotrexate in Patients to Induce Remission in Early Arthritis (EMPIRE) Unknown status NCT01303874 Phase 4 Etanercept (ETN);Placebo
26 Entecavir for Biological Agents Associated HBV Reactivation in Inflammatory Arthritis Patients Unknown status NCT01907230 Phase 4 Entecavir
27 Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis Unknown status NCT00291915 Phase 4 Adalimumab;Methotrexate
28 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
29 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4 Adalimumab treatment arm;Fumaric acid esters treatment group
30 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
31 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
32 The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis Unknown status NCT00808496 Phase 4
33 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
34 Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA) Completed NCT01382160 Phase 4
35 The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients Completed NCT01948388 Phase 4 corticotrophin 80 units
36 Study Comparing Enbrel (Etanercept) Plus Methotrexate Versus Enbrel Alone in Active Rheumatoid Arthritis Despite Current Methotrexate Therapy Completed NCT00244556 Phase 4 Methotrexate plus ENBREL or ENBREL alone
37 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4 Methotrexate
38 Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid Arthritis Completed NCT00695188 Phase 4 methotrexate;methotrexate
39 A Study of Iguratimod in Patients With Active Rheumatoid Arthritis Completed NCT01554917 Phase 4 Iguratimod
40 Treatment of Rheumatoid Arthritis With Roxithromycin Completed NCT00439062 Phase 4 Roxithromycin
41 Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis Completed NCT01225991 Phase 4 Milnacipran
42 Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel) Completed NCT01313208 Phase 4 etanercept;Placebo;DMARD Therapy
43 Relaxation Response Training for the Treatment of Rheumatoid Arthritis Completed NCT00056667 Phase 4
44 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
45 Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis Completed NCT01404429 Phase 4 Methotrexate
46 The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study. Completed NCT01270087 Phase 4 Adalimumab
47 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
48 Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects Completed NCT00252668 Phase 4 Etanercept;Methotrexate
49 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4 Repository corticotropin injection
50 A Comparison of Two Assessment Tools in Predicting Treatment Success of Cimzia in Rheumatoid Arthritis Subjects Completed NCT01255761 Phase 4

Search NIH Clinical Center for Rheumatoid Arthritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Rheumatoid Arthritis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: arthritis, rheumatoid

Genetic Tests for Rheumatoid Arthritis

Genetic tests related to Rheumatoid Arthritis:

# Genetic test Affiliating Genes
1 Rheumatoid Arthritis 29 CD244 CIITA IL10 NFKBIL1 PADI4 PTPN22 SLC22A4

Anatomical Context for Rheumatoid Arthritis

MalaCards organs/tissues related to Rheumatoid Arthritis:

41
Bone, T Cells, Lung, Endothelial, B Cells, Testes, Monocytes

The Foundational Model of Anatomy Ontology organs/tissues related to Rheumatoid Arthritis:

19
Joint
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Temporomandibular Joint Affected by disease

Publications for Rheumatoid Arthritis

Articles related to Rheumatoid Arthritis:

(show top 50) (show all 15060)
# Title Authors Year
1
Helminth-based therapies for rheumatoid arthritis: A systematic review and meta-analysis. ( 30529501 )
2019
2
Do neuronal microvascular activation and resultant dysfunction in rheumatoid arthritis contribute to chronic pain? ( 30531079 )
2019
3
A successful treatment of rheumatoid arthritis-related interstitial pneumonia with nintedanib. ( 30533376 )
2019
4
Histone Protein Epitope Mapping for Autoantibody Recognition in Rheumatoid Arthritis. ( 30539581 )
2019
5
Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran. ( 30551438 )
2019
6
Centromere Protein-F-like Pattern in a Patient With Rheumatoid Arthritis. ( 30430789 )
2019
7
Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis-A pilot study. ( 30399509 )
2019
8
Rheumatoid arthritis - a mathematical model. ( 30347191 )
2019
9
The prevalence of depression and insomnia symptoms among patients with rheumatoid arthritis and osteoarthritis in Poland: a case control study. ( 30286609 )
2019
10
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis. ( 29070531 )
2018
11
miR-522 Modulated the Expression of Proinflammatory Cytokines and Matrix Metalloproteinases Partly via Targeting Suppressor of Cytokine Signaling 3 in Rheumatoid Arthritis Synovial Fibroblasts. ( 29394098 )
2018
12
Discitis caused by rat bite fever in a rheumatoid arthritis patient on tocilizumab-first ever case. ( 29522179 )
2018
13
The association between caspase-5 gene polymorphisms and rheumatoid arthritis in a Chinese population. ( 29158166 )
2018
14
Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis. ( 29442475 )
2018
15
Usefulness of tocilizumab for treating rheumatoid arthritis with myelodysplastic syndrome: A case report and literature review. ( 29924032 )
2018
16
Rituximab therapy in rheumatoid arthritis and primary biliary cholangitis. ( 29338925 )
2018
17
Simultaneous Quadruple Joint Replacement (QJR) in Disabling Juvenile Rheumatoid Arthritis - a Case Report with Review of Literature. ( 29911143 )
2018
18
Causal association between rheumatoid arthritis and aA decreased risk of Alzheimer's disease : AA Mendelian randomization study. ( 29974225 )
2018
19
Involvement of M1/M2 macrophages in the pathomechanisms of intralymphatic histiocytosis associated with rheumatoid arthritis. ( 29905385 )
2018
20
Clinical, Imaging, and Pathological Suppression of Synovitis in Rheumatoid Arthritis: Is the Disease Curable? ( 29868592 )
2018
21
Burden of Depression among Working-Age Adults with Rheumatoid Arthritis. ( 29971163 )
2018
22
Tetraspanin CD82 affects migration, attachment and invasion of rheumatoid arthritis synovial fibroblasts. ( 29980577 )
2018
23
Use of biological disease modifying antirheumatic drugs in rheumatoid arthritis in Austria from 2008 to 2011 : AA retrospective analysis of 72% of the population. ( 29445863 )
2018
24
A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients. ( 29973208 )
2018
25
Physical Activity Assessment Using an Activity Tracker in Patients with Rheumatoid Arthritis and Axial Spondyloarthritis: Prospective Observational Study. ( 29295810 )
2018
26
High Adherence Observed to System-Level Performance Measures for Rheumatoid Arthritis in a National Early Arthritis Cohort Over 8 Years. ( 29450976 )
2018
27
Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population. ( 29978502 )
2018
28
Association between anti-citrullinated alpha enolase antibodies and clinical features in a cohort of patients with rheumatoid arthritis: a pilot study. ( 29976039 )
2018
29
The subjective components of the Disease Activity Score 28-joints (DAS28) in rheumatoid arthritis patients and coexisting fibromyalgia. ( 29955927 )
2018
30
Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis. ( 29870527 )
2018
31
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression. ( 29489833 )
2018
32
Folate Supplementation for Methotrexate Therapy in Patients With Rheumatoid Arthritis: A Systematic Review. ( 29975207 )
2018
33
Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study. ( 29394286 )
2018
34
Predictors of Treatment Response in Rheumatoid Arthritis. ( 29981377 )
2018
35
Physiotherapists' Adoption of a Theory-Based Skills Training Program in Guiding People with Rheumatoid Arthritis to Health-Enhancing Physical Activity. ( 29971578 )
2018
36
Difficult diagnosis of heart failure in rheumatoid arthritis: six-year follow-up of constrictive pericarditis. ( 29558019 )
2018
37
Proteomics analysis reveals differential pattern of widespread protein expression and novel role of histidine-rich glycoprotein and lipopolysaccharide-binding protein in rheumatoid arthritis. ( 29246875 )
2018
38
Non-obese visceral adiposity is associated with the risk of atherosclerosis in Japanese patients with rheumatoid arthritis: a cross-sectional study. ( 29974186 )
2018
39
Autoreactive T cells to citrullinated HSP90 are associated with interstitial lung disease in rheumatoid arthritis. ( 29968330 )
2018
40
Influence of removable prostheses on mastication in elderly subjects with rheumatoid arthritis. ( 29205439 )
2018
41
Hand functions in systemic sclerosis and rheumatoid arthritis and influence on clinical variables. ( 28322506 )
2018
42
Geographic variation in incidence and prevalence rates for rheumatoid arthritis in Saskatchewan, Canada 2001-2014. ( 29981076 )
2018
43
Cutaneous Mycobacterium Chelonae infection in a patient with Rheumatoid Arthritis treated with glucocorticoids. ( 29966767 )
2018
44
The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial. ( 28963724 )
2018
45
Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study. ( 28365812 )
2018
46
Plasma MicroRNA Profiles in Patients with Early Rheumatoid Arthritis Responding to Adalimumab plus Methotrexate vs Methotrexate Alone: A Placebo-controlled Clinical Trial. ( 29142030 )
2018
47
The effect of rheumatoid arthritis on the risk of cerebrovascular disease and coronary artery disease in young adults. ( 29861211 )
2018
48
Predictors for orthopaedic surgery in patients with rheumatoid arthritis: results from a retrospective cohort study of 1010 patients diagnosed from 1972 to 2009 and followed up until 2015. ( 29447542 )
2018
49
Levels of Health Theory With the Example of a Case of Juvenile Rheumatoid Arthritis. ( 29896977 )
2018
50
Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report. ( 29692623 )
2018