MCID: RHM011
MIFTS: 80

Rheumatoid Arthritis

Categories: Genetic diseases, Bone diseases, Respiratory diseases, Rare diseases

Aliases & Classifications for Rheumatoid Arthritis

MalaCards integrated aliases for Rheumatoid Arthritis:

Name: Rheumatoid Arthritis 57 38 12 76 25 75 37 29 55 6 43 3 15 63 73
Ra 57 25 75 3
Arthritis, Rheumatoid 25 44 40
Rheumatoid Arthritis, Susceptibility to 57
Arthritis or Polyarthritis, Rheumatic 12
Atrophic Arthritis 12

Characteristics:

OMIM:

57
Inheritance:
unproved inheritance


Classifications:



External Ids:

OMIM 57 180300
Disease Ontology 12 DOID:7148
ICD9CM 35 714.0
MeSH 44 D001172
NCIt 50 C27206 C2884
MedGen 42 C0003873
KEGG 37 H00630
UMLS 73 C0003873

Summaries for Rheumatoid Arthritis

MedlinePlus : 43 Rheumatoid arthritis (RA) is a form of arthritis that causes pain, swelling, stiffness and loss of function in your joints. It can affect any joint but is common in the wrist and fingers. More women than men get rheumatoid arthritis. It often starts in middle age and is most common in older people. You might have the disease for only a short time, or symptoms might come and go. The severe form can last a lifetime. Rheumatoid arthritis is different from osteoarthritis, the common arthritis that often comes with older age. RA can affect body parts besides joints, such as your eyes, mouth and lungs. RA is an autoimmune disease, which means the arthritis results from your immune system attacking your body's own tissues. No one knows what causes rheumatoid arthritis. Genes, environment, and hormones might contribute. Treatments include medicine, lifestyle changes, and surgery. These can slow or stop joint damage and reduce pain and swelling. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Rheumatoid Arthritis, also known as ra, is related to arthritis and palindromic rheumatism, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase, Non-Receptor Type 22), and among its related pathways/superpathways are Rheumatoid arthritis and LncRNA-mediated mechanisms of therapeutic resistance. The drugs Abatacept and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are abnormality of the nervous system and rheumatoid arthritis

OMIM : 57 Rheumatoid arthritis is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. (180300)

UniProtKB/Swiss-Prot : 75 Rheumatoid arthritis: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

CDC : 3 Rheumatoid arthritis, or RA, is an autoimmune and inflammatory disease, which means that your immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body.

Genetics Home Reference : 25 Rheumatoid arthritis is a disease that causes chronic abnormal inflammation, primarily affecting the joints. The most common signs and symptoms are pain, swelling, and stiffness of the joints. Small joints in the hands and feet are involved most often, although larger joints (such as the shoulders, hips, and knees) may become involved later in the disease. Joints are typically affected in a symmetrical pattern; for example, if joints in the hand are affected, both hands tend to be involved. People with rheumatoid arthritis often report that their joint pain and stiffness is worse when getting out of bed in the morning or after a long rest.

Disease Ontology : 12 An arthritis that is an autoimmune disease which attacks healthy cells and tissue located in joint.

PubMed Health : 63 About rheumatoid arthritis: There are many different rheumatic diseases, but rheumatoid arthritis is probably the most common. In rheumatoid arthritis, people usually have several permanently inflamed joints. This causes the joints to gradually become deformed and stiff. Over time the muscles also weaken.Someone with advanced rheumatoid arthritis may have difficulties with simple tasks such as washing themselves, eating with a knife and fork, or buttoning up a shirt. Other symptoms such as pain and fatigue can be very troublesome too. This disease can also affect other parts of the body, like the blood vessels or certain organs.Rheumatoid arthritis usually gradually worsens over the course of many years. Various treatments can relieve the pain and slow the progression of the disease. Early diagnosis and treatment can help to prevent damage to the joints.

Wikipedia : 76 Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. It typically... more...

Related Diseases for Rheumatoid Arthritis

Diseases in the Rheumatoid Arthritis family:

Rheumatoid Arthritis, Systemic Juvenile Juvenile Rheumatoid Arthritis

Diseases related to Rheumatoid Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 841)
# Related Disease Score Top Affiliating Genes
1 arthritis 35.2 CIITA HLA-DRB1 IL10 PTPN22
2 palindromic rheumatism 34.5 HLA-DRB1 PADI4 PTPN22
3 autoimmune disease 32.8 CIITA HLA-DRB1 IL10 PADI4 PTPN22
4 psoriatic arthritis 32.3 HLA-DRB1 MIR146A PTPN22
5 celiac disease 1 31.8 CIITA IL10 PTPN22
6 multiple sclerosis 31.7 CIITA HLA-DRB1 IL10 PADI4
7 vogt-koyanagi-harada disease 31.6 HLA-DRB1 IL10 PTPN22
8 microscopic polyangiitis 31.4 HLA-DRB1 IL10
9 polymyositis 31.1 MIR132 MIR155
10 systemic lupus erythematosus 31.0 HLA-DRB1 IL10 MALAT1 MIR150 PTPN22
11 discoid lupus erythematosus 30.7 HLA-DRB1 IL10
12 diffuse large b-cell lymphoma 30.2 HOTAIR MIR150 MIR155
13 diabetes mellitus 29.6 HLA-DRB1 MALAT1 MIR132 MIR155 PTPN22
14 leukemia, chronic lymphocytic 29.1 MIR132 MIR146A MIR150 MIR155
15 myeloma, multiple 28.3 H19 HOTAIR MALAT1 UCA1
16 renal cell carcinoma, nonpapillary 27.8 H19 HOTAIR MALAT1 UCA1
17 cervical cancer 27.5 H19 HOTAIR MALAT1 UCA1
18 leukemia, acute myeloid 27.5 HOTAIR MALAT1 MIR146A MIR155 UCA1
19 squamous cell carcinoma 27.2 H19 HOTAIR MALAT1 UCA1
20 bladder cancer 26.9 H19 HOTAIR MALAT1 UCA1 ZFAS1
21 gastric cancer 26.6 H19 HOTAIR MALAT1 MIR150 UCA1 ZFAS1
22 ovarian cancer 26.2 H19 HOTAIR MALAT1 MIR146A MIR155 UCA1
23 lung cancer 25.2 H19 HOTAIR MALAT1 MIR146A MIR150 MIR155
24 juvenile rheumatoid arthritis 12.8
25 rheumatoid arthritis, systemic juvenile 12.6
26 ras-associated autoimmune leukoproliferative disorder 12.5
27 felty syndrome 12.2
28 rheumatoid lung disease 11.7
29 polyarticular onset juvenile idiopathic arthritis 11.6
30 bone inflammation disease 11.6 HLA-DRB1 IL10 PADI4 PTPN22
31 adult-onset still's disease 11.6
32 rheumatoid vasculitis 11.6
33 carpal tunnel syndrome 11.5
34 juvenile myasthenia gravis 11.5 HLA-DRB1 IL10
35 sjogren syndrome 11.5
36 caplan's syndrome 11.4
37 rheumatoid factor-negative juvenile idiopathic arthritis 11.4 HLA-DRB1 PTPN22
38 systemic onset juvenile idiopathic arthritis 11.4
39 spondyloarthropathy 1 11.4
40 autoimmune addison disease 11.4 HLA-DRB1 PTPN22
41 interstitial lung disease 11.4
42 fibromyalgia 11.3
43 scleritis 11.3
44 bronchiolitis obliterans 11.3
45 amyloidosis aa 11.3
46 mixed connective tissue disease 11.3
47 rheumatoid nodulosis 11.3
48 progressive multifocal leukoencephalopathy 11.3
49 necrobiosis lipoidica 11.3
50 systemic scleroderma 11.3

Comorbidity relations with Rheumatoid Arthritis via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Bronchiectasis Bronchitis
Chronic Rheumatic Pericarditis Conn's Syndrome
Decubitus Ulcer Deficiency Anemia
Esophagitis Felty Syndrome
Heart Disease Hypersensitivity Vasculitis
Hypertension, Essential Hypothyroidism
Idiopathic Interstitial Pneumonia Immune Deficiency Disease
Iron Deficiency Anemia Mononeuropathy of the Median Nerve, Mild
Neutropenia Olecranon Bursitis
Oral Candidiasis Osteoarthritis
Osteoporosis Perforated Corneal Ulcer
Postinflammatory Pulmonary Fibrosis Premature Ovarian Failure 7
Protein-Energy Malnutrition Rheumatoid Lung Disease
Scleritis Sjogren Syndrome
Spondyloarthropathy 1 Systemic Lupus Erythematosus
Temporal Arteritis

Graphical network of the top 20 diseases related to Rheumatoid Arthritis:



Diseases related to Rheumatoid Arthritis

Symptoms & Phenotypes for Rheumatoid Arthritis

Symptoms via clinical synopsis from OMIM:

57
Joints:
rheumatoid arthritis

Limbs:
rheumatoid nodules

Vascular:
rheumatoid vasculitis

Neuro:
rheumatoid vasculitic mononeuritis

Immunology:
hla-drb1 association

Pulm:
rheumatoid lung disease

Heme:
felty syndrome


Clinical features from OMIM:

180300

Human phenotypes related to Rheumatoid Arthritis:

32 (show all 6)
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 32 HP:0000707
2 rheumatoid arthritis 32 HP:0001370
3 abnormality of blood and blood-forming tissues 32 HP:0001871
4 abnormality of the respiratory system 32 HP:0002086
5 vasculitis 32 HP:0002633
6 abnormality of the immune system 32 HP:0002715

UMLS symptoms related to Rheumatoid Arthritis:


back pain, muscle cramp, sciatica

Drugs & Therapeutics for Rheumatoid Arthritis

PubMedHealth treatment related to Rheumatoid Arthritis: 63

Rheumatoid arthritis is treated with both medication and non-drug approaches, such as physiotherapy. There are also various support aids available for making everyday tasks easier. Which of these treatments are suitable options will depend on, for example, how severe the inflammation and the symptoms are, how advanced the disease is, the expected progression of the disease – and how well previous treatments have worked.Medication canreduce inflammation and help keep the disease from getting worse,relieve symptoms like pain and swelling, andhelp people move their joints more easily again, or at least maintain joint flexibility for as long as possible.There is currently no cure for rheumatoid arthritis.Physiotherapy and sports can help improve or maintain flexibility, strength and joint function. Many types of sports are suitable for people who have rheumatoid arthritis, including cycling, brisk walking, dancing, aerobics, strength training, swimming and water aerobics. Occupational therapy can be used to maintain your flexibility and hand strength, and to learn how to cope with rheumatoid arthritis in everyday life.Psychological treatments are also sometimes used to help relieve pain and minimize the impact it has on everyday life. They are also intended to help relieve disease-related anxiety and depression that some people develop.Support aids are designed to help compensate for physical limitations and help with daily activities. These include orthopedic shoe inserts, grabbing aids and specially designed cutlery.

Drugs for Rheumatoid Arthritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 581)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 332348-12-6 10237
2
Adalimumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 331731-18-1 16219006
3
Etanercept Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 185243-69-0
4
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
5
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 174722-31-7 10201696
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
7
Hydroxychloroquine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 118-42-3 3652
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
9
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 2 16590-41-3 5360515
10
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
11
Sulfasalazine Approved Phase 4,Phase 3,Phase 2,Not Applicable 599-79-1 5353980 5359476
12
Leflunomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 75706-12-6 3899
13
Diclofenac Approved, Vet_approved Phase 4,Phase 3,Phase 2 15307-86-5 3033
14
Etoricoxib Approved, Investigational Phase 4,Phase 3,Phase 2 202409-33-4 123619
15
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 428863-50-7
16
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
17
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 104987-11-3 445643 439492
18
Dimethyl fumarate Approved, Investigational Phase 4,Phase 2 624-49-7 5271565 637568
19
Zinc Approved, Investigational Phase 4 7440-66-6 23994
20
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 169590-42-5 2662
21
Esomeprazole Approved, Investigational Phase 4,Phase 3 161796-78-7, 119141-88-7 4594 9579578
22
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
23
Acetaminophen Approved Phase 4,Phase 2,Phase 1 103-90-2 1983
24
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 22916-47-8 4189
26
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 128794-94-5 5281078
27
Mycophenolic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 24280-93-1 446541
28
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53-03-2 5865
29
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 5284616 6436030 46835353
30
chloroquine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 54-05-7 2719
31
Tofacitinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 477600-75-2
32
Aspirin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-78-2 2244
33
Ethanol Approved Phase 4,Phase 2 64-17-5 702
34
Azathioprine Approved Phase 4,Phase 3 446-86-6 2265
35
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
36
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 124-94-7 31307
37
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
38
Minocycline Approved, Investigational Phase 4,Phase 3 10118-90-8 5281021
39
Norepinephrine Approved Phase 4 51-41-2 439260
40
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
41
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
42
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
43
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
44
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
45
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
46
Promethazine Approved, Investigational Phase 4 60-87-7 4927
47
Betamethasone Approved, Vet_approved Phase 4,Phase 1,Phase 2 378-44-9 9782
48
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
49
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
50
Alendronate Approved Phase 4,Phase 2,Phase 3 121268-17-5, 66376-36-1 2088

Interventional clinical trials:

(show top 50) (show all 2464)
# Name Status NCT ID Phase Drugs
1 Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis Unknown status NCT01000441 Phase 4 infliximab, etanercept, adalimumab;abatacept, rituximab or tocilizumab
2 Vaccination Against Pertussis, Tetanus and Diphtheria in Patients Suffering From Rheumatoid Arthritis Unknown status NCT01301703 Phase 4
3 Effectiveness of Iguratimod Versus Placebo to Treat Early Rheumatoid Arthritis on MRI Unknown status NCT01893151 Phase 4 Iguratimod;Iguratimod placebo
4 Long-term Efficacy of Iguratimod Alone or Iguratimod in Combination With Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT01548001 Phase 4 Iguratimod;Methotrexate
5 TNF-blocking Therapy in Combination With Disease-modifying Antirheumatic Drugs in Early Rheumatoid Arthritis Unknown status NCT00908089 Phase 4 Trexan+Salazopyrin+Oxiklorin+prednisolone + infliximab;Trexan+Salazopyrin+Oxiklorin+prednisolone + placebo
6 Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis Unknown status NCT02275299 Phase 4 Iguratimod;Leflunomide;Methotrexate
7 Cell Immunity Response to Vaccination Against Influenza in Patients With Rheumatoid Arthritis Unknown status NCT01002716 Phase 4
8 Targeting Synovitis in Early Rheumatoid Arthritis Unknown status NCT00920478 Phase 4
9 Remission Induction in Very Early Rheumatoid Arthritis Unknown status NCT00523692 Phase 4 Etanercept, methotrexate and depomedrone;depemedrone
10 Uncontrolled Study to Evaluate Efficacy of Tocilizumab in Patients With Moderate or Severe Rheumatoid Arthritis Unknown status NCT02087696 Phase 4 Tocilizumab
11 REstore Working Ability in RheumatoiD Arthritis Unknown status NCT01405326 Phase 4
12 Comparison of the Effect of Etoricoxib and Diclofenac on Early Morning Activity in Rheumatoid Arthritis (RA) Unknown status NCT01067430 Phase 4 Etoricoxib;Diclofenac
13 Rheumatoid Arthritis Patients in Training Unknown status NCT00434200 Phase 4
14 Evaluation Effects of Treatment With IL-6R Inhibitor on Clinical Response and Biomarkers in Patients With Rheumatoid Arthritis (RA) Not Responding to DMARDs and/or a First Biological Agent. Unknown status NCT01835613 Phase 4
15 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
16 Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis Unknown status NCT00216177 Phase 4 Infliximab;Adalimumab
17 Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine Unknown status NCT01980836 Phase 4
18 Bucillamine Study of Holding Remission After Infliximab Dose-off Unknown status NCT00716248 Phase 4 bucillamine;methotrexate
19 Ultrasonographic Monitoring of Response to Infliximab in Patients With Rheumatoid Arthritis Unknown status NCT01282528 Phase 4
20 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
21 Clinical Study to Evaluate the Efficacy of Anakinra in Patients With Rheumatoid Arthritis and Diabetes Unknown status NCT02236481 Phase 4 Anakinra;TNF alpha inhibitors
22 Very Early Versus Delayed Etanercept in Patients With RA Unknown status NCT02433184 Phase 4 Etanercept;Methotrexate;Sulfasalazine;Hydroxychloroquine;Etanercept;Methotrexate
23 The Clinical Efficacy and Safety of Tacrolimus in Refractory Rheumatoid Arthritis Patients for 6 Months Treatment Unknown status NCT02837978 Phase 4 Tacrolimus;MTX
24 Efficacy and Safety of Adalimumab 80 mg Every Other Week With Methotrexate Unknown status NCT01270035 Phase 4 Adalimumab
25 Etanercept and Methotrexate in Patients to Induce Remission in Early Arthritis (EMPIRE) Unknown status NCT01303874 Phase 4 Etanercept (ETN);Placebo
26 Multicenter Randomized Prospective Trial Comparing Methotrexate Alone or in Combination With Adalimumab in Early Arthritis Unknown status NCT00291915 Phase 4 Adalimumab;Methotrexate
27 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
28 The Influence of Adalimumab on Cardiovascular and Metabolic Risk in Psoriasis Unknown status NCT01088165 Phase 4 Adalimumab treatment arm;Fumaric acid esters treatment group
29 Gastro-protective Effect and Pain Relief Effect of Naxozol Compared to Celecoxib in Patients With Osteoarthritis Unknown status NCT02355236 Phase 4 Naproxen/Esomeprazol 500/20mg;Celecoxib 200mg;Naxozol-Placebo;Comparator-Placebo
30 Close Kinect Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome Unknown status NCT02241148 Phase 4 Acetaminophen 500mg
31 The Effect of Biannual Monitoring With Magnetic Resonance Imaging (MRI), X-ray, or Usual Care on Treatment for Inflammatory Arthritis Unknown status NCT00808496 Phase 4
32 Everolimus + Very Low Tacrolimus vs Enteric-coated Mycophenolate Sodium + Low Tacrolimus in de Novo Renal Transplant Unknown status NCT02084446 Phase 4 Everolimus;Very Low Tacrolimus;Low Tacrolimus;Steroids;Thymoglobulin;Sodium Mycophenolate
33 Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA) Completed NCT01382160 Phase 4
34 The Effect of Corticotrophin (ACTH) in Combination With Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients Completed NCT01948388 Phase 4 corticotrophin 80 units
35 Study Comparing Enbrel (Etanercept) Plus Methotrexate Versus Enbrel Alone in Active Rheumatoid Arthritis Despite Current Methotrexate Therapy Completed NCT00244556 Phase 4 Methotrexate plus ENBREL or ENBREL alone
36 A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA) Completed NCT01185288 Phase 4 Methotrexate
37 Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid Arthritis Completed NCT00695188 Phase 4 methotrexate;methotrexate
38 A Study of Iguratimod in Patients With Active Rheumatoid Arthritis Completed NCT01554917 Phase 4 Iguratimod
39 Milnacipran for Treatment of Pain in Older Adults With Rheumatoid Arthritis Completed NCT01225991 Phase 4 Milnacipran
40 Treatment of Rheumatoid Arthritis With Roxithromycin Completed NCT00439062 Phase 4 Roxithromycin
41 Moderate Rheumatoid Arthritis (RA) With Etanercept (Enbrel) Completed NCT01313208 Phase 4 etanercept;Placebo;DMARD Therapy
42 Relaxation Response Training for the Treatment of Rheumatoid Arthritis Completed NCT00056667 Phase 4
43 A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs Completed NCT01034397 Phase 4 tocilizumab [RoActemra/Actemra];placebo;non-biological DMARDs
44 Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid Arthritis Completed NCT01404429 Phase 4 Methotrexate
45 The Effect of Adalimumab (Humira) on Vascular Abnormalities in Rheumatoid Arthritis. A Pilot Study. Completed NCT01270087 Phase 4 Adalimumab
46 Study of the Optimal Protocol for Methotrexate and Adalimumab Combination Therapy in Early Rheumatoid Arthritis Completed NCT00420927 Phase 4 methotrexate
47 Study Evaluating the Combination of Etanercept and Methotrexate in Rheumatoid Arthritis Subjects Completed NCT00252668 Phase 4 Etanercept;Methotrexate
48 Repository Corticotropin Injection To Treat Rheumatoid Arthritis Patients Who Have Failed Three Biologic Therapies. Completed NCT01966718 Phase 4 Repository corticotropin injection
49 A Comparison of Two Assessment Tools in Predicting Treatment Success of Cimzia in Rheumatoid Arthritis Subjects Completed NCT01255761 Phase 4
50 Evaluation of EULAR-RAID Score in Rheumatoid Arthritis Patients Completed NCT00768053 Phase 4 Etanercept

Search NIH Clinical Center for Rheumatoid Arthritis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Rheumatoid Arthritis cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: arthritis, rheumatoid

Genetic Tests for Rheumatoid Arthritis

Genetic tests related to Rheumatoid Arthritis:

# Genetic test Affiliating Genes
1 Rheumatoid Arthritis 29 CD244 CIITA HLA-DRB1 IL10 NFKBIL1 PADI4 PTPN22 SLC22A4

Anatomical Context for Rheumatoid Arthritis

The Foundational Model of Anatomy Ontology organs/tissues related to Rheumatoid Arthritis:

19
Joint

MalaCards organs/tissues related to Rheumatoid Arthritis:

41
Bone, T Cells, Lung, B Cells, Endothelial, Monocytes, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Rheumatoid Arthritis:
# Tissue Anatomical CompartmentCell Relevance
1 Cartilage Temporomandibular Joint Affected by disease

Publications for Rheumatoid Arthritis

Articles related to Rheumatoid Arthritis:

(show top 50) (show all 11961)
# Title Authors Year
1
Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis. ( 29070531 )
2018
2
miR-522 Modulated the Expression of Proinflammatory Cytokines and Matrix Metalloproteinases Partly via Targeting Suppressor of Cytokine Signaling 3 in Rheumatoid Arthritis Synovial Fibroblasts. ( 29394098 )
2018
3
Discitis caused by rat bite fever in a rheumatoid arthritis patient on tocilizumab-first ever case. ( 29522179 )
2018
4
The association between caspase-5 gene polymorphisms and rheumatoid arthritis in a Chinese population. ( 29158166 )
2018
5
Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis. ( 29442475 )
2018
6
Usefulness of tocilizumab for treating rheumatoid arthritis with myelodysplastic syndrome: A case report and literature review. ( 29924032 )
2018
7
Rituximab therapy in rheumatoid arthritis and primary biliary cholangitis. ( 29338925 )
2018
8
Simultaneous Quadruple Joint Replacement (QJR) in Disabling Juvenile Rheumatoid Arthritis - a Case Report with Review of Literature. ( 29911143 )
2018
9
Causal association between rheumatoid arthritis and aA decreased risk of Alzheimer's disease : AA Mendelian randomization study. ( 29974225 )
2018
10
Involvement of M1/M2 macrophages in the pathomechanisms of intralymphatic histiocytosis associated with rheumatoid arthritis. ( 29905385 )
2018
11
Clinical, Imaging, and Pathological Suppression of Synovitis in Rheumatoid Arthritis: Is the Disease Curable? ( 29868592 )
2018
12
Burden of Depression among Working-Age Adults with Rheumatoid Arthritis. ( 29971163 )
2018
13
Tetraspanin CD82 affects migration, attachment and invasion of rheumatoid arthritis synovial fibroblasts. ( 29980577 )
2018
14
Use of biological disease modifying antirheumatic drugs in rheumatoid arthritis in Austria from 2008 to 2011 : AA retrospective analysis of 72% of the population. ( 29445863 )
2018
15
A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients. ( 29973208 )
2018
16
Physical Activity Assessment Using an Activity Tracker in Patients with Rheumatoid Arthritis and Axial Spondyloarthritis: Prospective Observational Study. ( 29295810 )
2018
17
High Adherence Observed to System-Level Performance Measures for Rheumatoid Arthritis in a National Early Arthritis Cohort Over 8 Years. ( 29450976 )
2018
18
Association of single nucleotide polymorphisms in resistin gene with rheumatoid arthritis in a Chinese population. ( 29978502 )
2018
19
Association between anti-citrullinated alpha enolase antibodies and clinical features in a cohort of patients with rheumatoid arthritis: a pilot study. ( 29976039 )
2018
20
The subjective components of the Disease Activity Score 28-joints (DAS28) in rheumatoid arthritis patients and coexisting fibromyalgia. ( 29955927 )
2018
21
Toxoplasmosis seroprevalence in rheumatoid arthritis patients: A systematic review and meta-analysis. ( 29870527 )
2018
22
Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression. ( 29489833 )
2018
23
Folate Supplementation for Methotrexate Therapy in Patients With Rheumatoid Arthritis: A Systematic Review. ( 29975207 )
2018
24
Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: A pilot case-control study. ( 29394286 )
2018
25
Predictors of Treatment Response in Rheumatoid Arthritis. ( 29981377 )
2018
26
Physiotherapists' Adoption of a Theory-Based Skills Training Program in Guiding People with Rheumatoid Arthritis to Health-Enhancing Physical Activity. ( 29971578 )
2018
27
Difficult diagnosis of heart failure in rheumatoid arthritis: six-year follow-up of constrictive pericarditis. ( 29558019 )
2018
28
Proteomics analysis reveals differential pattern of widespread protein expression and novel role of histidine-rich glycoprotein and lipopolysaccharide-binding protein in rheumatoid arthritis. ( 29246875 )
2018
29
Non-obese visceral adiposity is associated with the risk of atherosclerosis in Japanese patients with rheumatoid arthritis: a cross-sectional study. ( 29974186 )
2018
30
Autoreactive T cells to citrullinated HSP90 are associated with interstitial lung disease in rheumatoid arthritis. ( 29968330 )
2018
31
Influence of removable prostheses on mastication in elderly subjects with rheumatoid arthritis. ( 29205439 )
2018
32
Hand functions in systemic sclerosis and rheumatoid arthritis and influence on clinical variables. ( 28322506 )
2018
33
Geographic variation in incidence and prevalence rates for rheumatoid arthritis in Saskatchewan, Canada 2001-2014. ( 29981076 )
2018
34
Cutaneous Mycobacterium Chelonae infection in a patient with Rheumatoid Arthritis treated with glucocorticoids. ( 29966767 )
2018
35
The anti-CD6 antibody itolizumab provides clinical benefit without lymphopenia in rheumatoid arthritis patients: results from a 6-month, open-label Phase I clinical trial. ( 28963724 )
2018
36
Serum levels of matrix metalloproteinase-3 and autoantibodies related to rheumatoid arthritis in the general Japanese population and their association with osteoporosis and osteoarthritis: the ROAD study. ( 28365812 )
2018
37
Plasma MicroRNA Profiles in Patients with Early Rheumatoid Arthritis Responding to Adalimumab plus Methotrexate vs Methotrexate Alone: A Placebo-controlled Clinical Trial. ( 29142030 )
2018
38
The effect of rheumatoid arthritis on the risk of cerebrovascular disease and coronary artery disease in young adults. ( 29861211 )
2018
39
Predictors for orthopaedic surgery in patients with rheumatoid arthritis: results from a retrospective cohort study of 1010 patients diagnosed from 1972 to 2009 and followed up until 2015. ( 29447542 )
2018
40
Levels of Health Theory With the Example of a Case of Juvenile Rheumatoid Arthritis. ( 29896977 )
2018
41
Nephritis, cerebritis, and myositis after adalimumab therapy in a patient with rheumatoid arthritis: a case report. ( 29692623 )
2018
42
Radiological fibrosis score is strongly associated with worse survival in rheumatoid arthritis-related interstitial lung disease. ( 29446698 )
2018
43
Rheumatoid arthritis treatment in patients with a history of cancer. ( 29389831 )
2018
44
Are aortic coarctation and rheumatoid arthritis different models of aortic stiffness? Data from an echocardiographic study. ( 29940971 )
2018
45
Tofacitinib Therapy for Rheumatoid Arthritis: A Direct Comparison Study between Biologic-naA^ve and Experienced Patients. ( 29151519 )
2018
46
LncRNA ZFAS1 promotes cell migration and invasion of fibroblast-like synoviocytes by suppression of miR-27a in rheumatoid arthritis. ( 28721682 )
2018
47
Reconceptualizing motivation for smoking cessation among people with rheumatoid arthritis as incentives and facilitators. ( 29235264 )
2018
48
Elevated Levels of Soluble ST2 were Associated with Rheumatoid Arthritis Disease Activity and Ameliorated Inflammation in Synovial Fibroblasts. ( 29363647 )
2018
49
Multiple extra-articular synovial cysts accompanied by rheumatoid arthritis in the bilateral elbow joints: A case report. ( 29443754 )
2018
50
Physiotherapists' management of challenging situations in guiding people with rheumatoid arthritis to health-enhancing physical activity. ( 29447492 )
2018