MCID: RHM036
MIFTS: 36

Rheumatoid Arthritis Interstitial Lung Disease

Categories: Bone diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Arthritis Interstitial Lung Disease

MalaCards integrated aliases for Rheumatoid Arthritis Interstitial Lung Disease:

Name: Rheumatoid Arthritis Interstitial Lung Disease 12 15
Rheumatoid Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:849
ICD9CM 34 714.81
ICD10 32 J99.0 M05.1

Summaries for Rheumatoid Arthritis Interstitial Lung Disease

Disease Ontology : 12 An interstitial lung disease that is characterized by the development of pleuroparenchymal disease secondary to rheumatoid arthritis, including pleural effusions, pleural fibrosis, pulmonary vascular disease, and airway complications.

MalaCards based summary : Rheumatoid Arthritis Interstitial Lung Disease, also known as rheumatoid lung, is related to interstitial lung disease and bronchiolitis. An important gene associated with Rheumatoid Arthritis Interstitial Lung Disease is TNFRSF1B (TNF Receptor Superfamily Member 1B), and among its related pathways/superpathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and 14-3-3 and Regulation of BAD Activity. The drugs Methotrexate and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and colon, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Rheumatoid Arthritis Interstitial Lung Disease

Diseases related to Rheumatoid Arthritis Interstitial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 359)
# Related Disease Score Top Affiliating Genes
1 interstitial lung disease 31.0 TNF SFTPD CRP
2 bronchiolitis 30.2 TNF SFTPD CRP
3 vasculitis 30.1 TNFRSF1B TNF CRP
4 bronchiolitis obliterans 30.0 TNF SFTPD CRP
5 arthritis 29.9 TNFRSF1B TNF IL1RN CRP
6 rheumatoid arthritis 29.8 TNFRSF1B TNF IL1RN CRP CD4
7 pleural empyema 29.6 CRP CD4
8 cryptogenic organizing pneumonia 29.5 TNF SFTPD CRP CD4
9 pulmonary disease, chronic obstructive 29.4 TNF SFTPD CRP CD4
10 connective tissue disease 29.3 TNFRSF1B TNF SFTPD CRP CD4
11 pleural disease 29.3 TNF CRP CD4
12 systemic scleroderma 28.9 TNF SFTPD CRP CD4
13 pulmonary fibrosis, idiopathic 28.7 TNF SFTPD IL1RN CRP CD4
14 pneumonia 28.7 TNFRSF1B TNF SFTPD IL1RN CRP
15 exanthem 28.3 TNFRSF1B TNF IL1RN CRP CD4
16 lung disease 10.7
17 chromophil adenoma of the kidney 10.4 TNFRSF1B TNF
18 necrobiosis lipoidica 10.4 TNFRSF1B TNF
19 macrophage activation syndrome 10.4 TNFRSF1B TNF
20 post-transplant lymphoproliferative disease 10.4 TNFRSF1B TNF
21 palindromic rheumatism 10.4 TNFRSF1B TNF
22 pulmonary fibrosis 10.3
23 pityriasis rubra pilaris 10.3 TNFRSF1B TNF
24 orbital plasma cell granuloma 10.3 TNFRSF1B CRP
25 chronic orbital inflammation 10.3 TNFRSF1B CRP
26 drug reaction with eosinophilia and systemic symptoms 10.3 TNF CRP
27 ankylosing spondylitis 1 10.3 TNFRSF1B CRP
28 diabetes mellitus, insulin-dependent, 23 10.2 TNF CD4
29 posterior scleritis 10.2 TNF CRP
30 ankylosing spondylitis 3 10.2 TNFRSF1B CRP
31 louse-borne relapsing fever 10.2 TNF CRP
32 relapsing fever 10.2 TNF CRP
33 metal allergy 10.2 TNF CD4
34 tuberculous epididymitis 10.2 TNF CRP
35 central nervous system tuberculosis 10.2 TNF CD4
36 cardiac rupture 10.2 TNF CRP
37 inflammatory and toxic neuropathy 10.2 TNF CRP
38 lymph node tuberculosis 10.2 TNF CD4
39 bird fancier's lung 10.2 SFTPD CD4
40 tracheitis 10.2 TNF CRP
41 aspiration pneumonitis 10.2 TNF CRP
42 superficial basal cell carcinoma 10.2 TNF CD4
43 pneumonic tularemia 10.2 TNF CD4
44 toxic megacolon 10.2 TNF CRP
45 tularemia 10.2 TNF CD4
46 farmer's lung 10.2 TNF CD4
47 blastomycosis 10.2 TNF CD4
48 orbital disease 10.2 TNFRSF1B CRP
49 pneumonic plague 10.2 TNF CD4
50 scarlet fever 10.2 TNF CRP

Graphical network of the top 20 diseases related to Rheumatoid Arthritis Interstitial Lung Disease:



Diseases related to Rheumatoid Arthritis Interstitial Lung Disease

Symptoms & Phenotypes for Rheumatoid Arthritis Interstitial Lung Disease

MGI Mouse Phenotypes related to Rheumatoid Arthritis Interstitial Lung Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.56 CD4 CRP IL1RN PADI2 SFTPD TDRKH
2 immune system MP:0005387 9.17 CD4 CRP IL1RN PADI2 SFTPD TNF

Drugs & Therapeutics for Rheumatoid Arthritis Interstitial Lung Disease

Drugs for Rheumatoid Arthritis Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 4 59-05-2, 1959-05-2 126941
2
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
3
leucovorin Approved Phase 4 58-05-9 6006 143
4
Tofacitinib Approved, Investigational Phase 4 477600-75-2
5
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
6 Antirheumatic Agents Phase 4
7 Immunosuppressive Agents Phase 4
8 Immunologic Factors Phase 4
9 Protein Kinase Inhibitors Phase 4
10 Vitamin B Complex Phase 4
11 Folic Acid Antagonists Phase 4
12 Dermatologic Agents Phase 4
13 Folate Phase 4
14 Vitamin B9 Phase 4
15 Antimetabolites Phase 4
16
tannic acid Approved Phase 2 1401-55-4
17
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
18
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
19
Abatacept Approved Phase 2 332348-12-6 10237
20 Analgesics Phase 2
21 Analgesics, Non-Narcotic Phase 2
22 Anti-Inflammatory Agents Phase 2
23 Anti-Inflammatory Agents, Non-Steroidal Phase 2
24
Carbon monoxide Approved, Investigational 630-08-0 281
25 Immunoglobulins
26 Antibodies

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Effects of Tofacitinib vs Methotrexate on Clinical and Molecular Disease Activity Markers in Joints and Lungs in Early Rheumatoid Arthritis (PULMORA) - A Randomized, Controlled, Open-label, Assessor-blinded, Phase IV Trial Not yet recruiting NCT04311567 Phase 4 Tofacitinib;Methotrexate
2 AAFA™ Fish Oil Nutritional Supplementation to Maintain Body Weight in Patients With Disease-Related Weight Loss Completed NCT00094562 Phase 2 Fish oil supplement
3 Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients With Rheumatoid Arthritis Interstitial Lung Disease (TRAIL1) Recruiting NCT02808871 Phase 2 Pirfenidone;Placebo
4 Safety of Abatacept in Rheumatoid Arthritis Associated Interstitial Lung Disease: A Feasibility Trial Recruiting NCT03084419 Phase 2 Abatacept
5 Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis: Effect of Duration of Disease Unknown status NCT01641705
6 Fibrocytes in Rheumatoid Arthritis, Asthma and Interstitial Lung-disease. Completed NCT02711657
7 Deciphering Rheumatoid Arthritis-associated Interstitial Lung Disease Pathogenesis 2 Recruiting NCT04227535
8 Interstitial Lung Disease in Early Rheumatoid Arthritis Recruiting NCT03977415
9 Change in Serum and Sputum Biomarkers Over Time in the Development of Rheumatoid Arthritis-associated Lung Disease Recruiting NCT03616158
10 Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease Recruiting NCT03297775
11 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826
12 Early Rheumatoid Arthritis Lung Disease Study Recruiting NCT03192267
13 Treatment Outcome and Prognostic Factors for RA Patients With Interstitial Lung Disease Recruiting NCT03099525
14 Factors of ILD in Newly Diagnosed Rheumatoid Arthritis Recruiting NCT04002765
15 CXCL10 As a Biomarker Of Interstitial Lung Disease in Patients With Rheumatoid Arthritis Not yet recruiting NCT04356066
16 Role of Lysophosphatidic Acid and Autotaxin in Rheumatoid Arthritis-associated Interstitial Lung Disease Not yet recruiting NCT04284735
17 BERTHA Study: Rheumatoid Arthritis-Associated Interstitial Lung Disease: Characterization of Lung Disease Progression. A Multicenter, Observational Study Not yet recruiting NCT04136223
18 Assessment of Interstitial Lung Disease in Rheumatoid Arthritis by Lung Ultrasound Not yet recruiting NCT04195789
19 Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies Suspended NCT01776398

Search NIH Clinical Center for Rheumatoid Arthritis Interstitial Lung Disease

Genetic Tests for Rheumatoid Arthritis Interstitial Lung Disease

Anatomical Context for Rheumatoid Arthritis Interstitial Lung Disease

MalaCards organs/tissues related to Rheumatoid Arthritis Interstitial Lung Disease:

40
Lung, Lymph Node, Colon, Neutrophil

Publications for Rheumatoid Arthritis Interstitial Lung Disease

Articles related to Rheumatoid Arthritis Interstitial Lung Disease:

(show top 50) (show all 182)
# Title Authors PMID Year
1
Is incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts. 61
31061059 2019
2
Pulmonary Complications of Rheumatoid Arthritis. 61
31137060 2019
3
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. 61
30442831 2019
4
Rheumatoid pulmonary nodules: clinical and imaging features compared with malignancy. 61
30288558 2019
5
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. 61
30710005 2019
6
Methotrexate-Associated Pneumonitis and Rheumatoid Arthritis-Interstitial Lung Disease: Current Concepts for the Diagnosis and Treatment. 61
31709258 2019
7
Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy? 61
30874239 2018
8
Autoinflammatory disease in the lung. 61
29676014 2018
9
Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease. 61
29422289 2018
10
[Senile rheumatoid arthritis associated with rheumatoid lung: a caricatural observation]. 61
30627314 2018
11
Practical Approach to the Evaluation and Management of Rheumatoid Arthritis-Interstitial Lung Disease Based on its Proven and Hypothetical Mechanisms. 61
29077694 2017
12
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis. 61
28495692 2017
13
[The 456th case: polyarthritis, dry cough, dyspnea on exertion]. 61
28460514 2017
14
Rheumatoid lung nodulosis during anti-TNF therapy. 61
28038860 2017
15
The relationship of SSRI and SNRI usage with interstitial lung disease and bronchiectasis in an elderly population: a case-control study. 61
29200837 2017
16
NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung. 61
26743485 2016
17
An Autopsy Case of Fulminant Amebic Colitis in a Patient with a History of Rheumatoid Arthritis. 61
27382497 2016
18
An interesting finding of multiple calcified pulmonary nodules in a patient with rheumatoid arthritis. 61
30364404 2016
19
Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model. 61
26881215 2016
20
Rheumatoid lung nodule. 61
26516255 2015
21
Rheumatoid Arthritis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: Shared Mechanistic and Phenotypic Traits Suggest Overlapping Disease Mechanisms. 61
26696331 2015
22
Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. 61
25822095 2015
23
Rheumatoid lung. 61
25956496 2015
24
Idiopathic pleuroparenchymal fibroelastosis presenting in recurrent pneumothorax: a case report. 61
25368665 2014
25
Rheumatoid arthritis interstitial lung disease: time to take notice. 61
24703236 2014
26
[Pathogenesis of rheumatoid arthritis]. 61
25427390 2014
27
Smoking-related emphysema is associated with idiopathic pulmonary fibrosis and rheumatoid lung. 61
23819865 2013
28
Rituximab: rescue therapy in life-threatening complications or refractory autoimmune diseases: a single center experience. 61
23239037 2013
29
A rheumatoid nodule in an unusual location: mediastinal lymph node. 61
23645652 2013
30
Acute exacerbations of idiopathic pulmonary fibrosis. 61
24157720 2013
31
Progressive intraparenchymal lung nodules dissemination in a heavy smoker and seropositive rheumatoid arthritis suspected of tuberculosis relapse. 61
24068421 2013
32
Diagnostic performances of high resolution trans-thoracic lung ultrasonography in pulmonary alveoli-interstitial involvement of rheumatoid lung disease. 61
23936595 2013
33
Role of (18)F-FDG PET Scan in Rheumatoid Lung Nodule: Case Report and Review of the Literature. 61
23984160 2013
34
Chronic inflammation and lung fibrosis: pleotropic syndromes but limited distinct phenotypes. 61
22806097 2012
35
Rheumatoid lung disease: prognostic analysis of 54 biopsy-proven cases. 61
22560113 2012
36
[Intrathoracic lymphadenopathy: an unusual manifestation of rheumatoid arthritis]. 61
22305139 2012
37
Intracellular detection of interleukin 17 and other cytokines in human bronchoalveolar lavage fluid: a first assessment. 61
22020264 2012
38
[Interstitial pneumonia with anti-PL-7 antibody difficult to distinguish from rheumatoid lung]. 61
22117318 2011
39
Rheumatoid nodule and combined pulmonary carcinoma: topographic correlations; a case report and review of the literature. 61
21210348 2011
40
Rheumatoid arthritis-interstitial lung disease-associated mortality. 61
20851924 2011
41
Rheumatoid arthritis: spectrum of computed tomographic findings in pulmonary diseases. 61
20875611 2010
42
Adalimumab-induced acute pneumonitis in a patient with rheumatoid arthritis. 61
20511978 2010
43
[Rheumatoid arthritis diagnosis based on the detection of a pulmonary rheumatoid nodule in a patient with Hansen's disease]. 61
20163026 2010
44
[A case of rheumatoid arthritis with pneumothorax due to subpleural pulmonary rheumatoid nodules]. 61
19068769 2008
45
Rheumatoid arthritis interstitial lung disease: mycophenolate mofetil as an antifibrotic and disease-modifying antirheumatic drug. 61
18695091 2008
46
Rheumatoid lung disease as seen on PET/CT scan. 61
17710040 2007
47
Rheumatoid lung disease. 61
17684286 2007
48
Massive spontaneous hemopneumothorax complicating rheumatoid lung disease. 61
17383372 2007
49
Multiple calcified pulmonary nodules: an unusual presentation of rheumatoid lung. 61
17293222 2007
50
[A case of rheumatoid lung complicated by SELAPINA-induced pneumonia]. 61
17144587 2006

Variations for Rheumatoid Arthritis Interstitial Lung Disease

Expression for Rheumatoid Arthritis Interstitial Lung Disease

Search GEO for disease gene expression data for Rheumatoid Arthritis Interstitial Lung Disease.

Pathways for Rheumatoid Arthritis Interstitial Lung Disease

Pathways related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 TNFRSF1B TNF
2 10.76 TNFRSF1B TNF
3 10.62 TNF CD4
4 10.49 TNFRSF1B TNF IL1RN
5 10.23 TNF CRP

GO Terms for Rheumatoid Arthritis Interstitial Lung Disease

Cellular components related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.13 TNFRSF1B TNF CD4
2 extracellular region GO:0005576 9.1 TNFRSF1B TNF SFTPD PADI2 IL1RN CRP

Biological processes related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 TNFRSF1B TNF IL1RN CD4
2 inflammatory response GO:0006954 9.46 TNFRSF1B TNF IL1RN CRP
3 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.26 TNFRSF1B TNF
4 negative regulation of lipid storage GO:0010888 8.96 TNF CRP
5 cytokine-mediated signaling pathway GO:0019221 8.92 TNFRSF1B TNF IL1RN CD4

Sources for Rheumatoid Arthritis Interstitial Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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