MCID: RHM036
MIFTS: 37

Rheumatoid Arthritis Interstitial Lung Disease

Categories: Bone diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Arthritis Interstitial Lung Disease

Summaries for Rheumatoid Arthritis Interstitial Lung Disease

Disease Ontology : 12 An interstitial lung disease that is characterized by the development of pleuroparenchymal disease secondary to rheumatoid arthritis, including pleural effusions, pleural fibrosis, pulmonary vascular disease, and airway complications.

MalaCards based summary : Rheumatoid Arthritis Interstitial Lung Disease, also known as rheumatoid lung, is related to interstitial lung disease and lung disease. An important gene associated with Rheumatoid Arthritis Interstitial Lung Disease is CEL (Carboxyl Ester Lipase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. The drugs Pirfenidone and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and colon.

Related Diseases for Rheumatoid Arthritis Interstitial Lung Disease

Diseases related to Rheumatoid Arthritis Interstitial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 interstitial lung disease 31.1 MUC1 SFTPD TNF
2 lung disease 31.0 IL17A SFTPD TNF
3 arthritis 30.4 IL17A IL1RN MMP3 TNF TNFRSF1B
4 rheumatoid arthritis 30.4 IL17A IL1RN MMP3 TNF TNFRSF1B
5 pulmonary fibrosis, idiopathic 29.1 CCL18 IL1RN MUC1 SFTPD TNF
6 pleuroparenchymal fibroelastosis 10.3 MUC1 SFTPD
7 chronic orbital inflammation 10.3 MUC1 TNFRSF1B
8 acute interstitial pneumonia 10.3 MUC1 SFTPD
9 chondromalacia 10.3 IL1RN TNFRSF1B
10 skin sarcoidosis 10.3 TNF TNFRSF1B
11 vulvar vestibulitis syndrome 10.3 IL1RN TNF
12 chronic gonococcal salpingitis 10.3 TNF TNFRSF1B
13 granulomatous dermatitis 10.3 TNF TNFRSF1B
14 osteosclerotic myeloma 10.3 IL1RN TNF
15 peroneal neuropathy 10.3 TNF TNFRSF1B
16 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
17 filamentary keratitis 10.2 IL17A MUC1
18 acute salpingitis 10.2 TNF TNFRSF1B
19 chickenpox 10.2 MUC1 TNFRSF1B
20 post-transplant lymphoproliferative disease 10.2 TNF TNFRSF1B
21 hydrarthrosis 10.2 IL1RN MMP3
22 trichosporonosis 10.2 IL17A TNF
23 anterior scleritis 10.2 IL1RN TNFRSF1B
24 nasopharyngitis 10.2 IL17A TNFRSF1B
25 chronic salpingitis 10.2 TNF TNFRSF1B
26 central nervous system vasculitis 10.2 IL17A TNF
27 autoimmune disease of eyes, ear, nose and throat 10.2 IL17A TNF
28 transverse myelitis 10.2 IL17A TNF
29 myelitis 10.2 IL17A TNF
30 primary systemic mycosis 10.1 IL17A TNF
31 aseptic meningitis 10.1 IL1RN TNF
32 mycoplasma pneumoniae pneumonia 10.1 IL17A TNF
33 synovitis 10.1 IL1RN MMP3 TNF
34 juvenile ankylosing spondylitis 10.1 IL1RN TNF TNFRSF1B
35 scleral disease 10.1 IL1RN TNF TNFRSF1B
36 pustulosis of palm and sole 10.1 IL1RN TNF TNFRSF1B
37 hypersensitivity reaction type iv disease 10.1 IL1RN TNF TNFRSF1B
38 exanthem 10.1 IL1RN TNF TNFRSF1B
39 juvenile rheumatoid arthritis 10.1 IL1RN TNF TNFRSF1B
40 pneumocystosis 10.1 MUC1 SFTPD TNF
41 spondyloarthropathy 10.1 IL17A MMP3 TNF
42 stromal keratitis 10.1 IL17A TNF
43 silicosis 10.1 IL1RN SFTPD TNF
44 connective tissue disease 10.1 MUC1 SFTPD TNF
45 adult-onset still's disease 10.0 IL1RN TNF
46 immune system disease 10.0 IL17A MUC1 TNF
47 periodontitis 10.0 IL17A MMP3 TNF
48 panuveitis 10.0 IL17A TNF TNFRSF1B
49 proteasome-associated autoinflammatory syndrome 1 10.0 IL17A IL1RN TNF
50 hidradenitis suppurativa 10.0 IL17A TNF

Graphical network of the top 20 diseases related to Rheumatoid Arthritis Interstitial Lung Disease:



Diseases related to Rheumatoid Arthritis Interstitial Lung Disease

Symptoms & Phenotypes for Rheumatoid Arthritis Interstitial Lung Disease

Drugs & Therapeutics for Rheumatoid Arthritis Interstitial Lung Disease

Drugs for Rheumatoid Arthritis Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
2 Analgesics, Non-Narcotic Phase 2
3 Peripheral Nervous System Agents Phase 2
4 Anti-Inflammatory Agents Phase 2
5 Antirheumatic Agents Phase 2
6 Analgesics Phase 2
7 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase ll Study of Pirfenidone in Patients With RAILD (TRAIL1) Recruiting NCT02808871 Phase 2 Pirfenidone;Placebo
2 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Active Rheumatoid Arthritis Terminated NCT01261403 Phase 2 Vehicle Controlled Placebo
3 Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis Unknown status NCT01641705
4 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826

Search NIH Clinical Center for Rheumatoid Arthritis Interstitial Lung Disease

Genetic Tests for Rheumatoid Arthritis Interstitial Lung Disease

Anatomical Context for Rheumatoid Arthritis Interstitial Lung Disease

MalaCards organs/tissues related to Rheumatoid Arthritis Interstitial Lung Disease:

42
Bone, Lung, Colon, Skin, Eye, Spinal Cord

Publications for Rheumatoid Arthritis Interstitial Lung Disease

Articles related to Rheumatoid Arthritis Interstitial Lung Disease:

(show top 50) (show all 74)
# Title Authors Year
1
Is incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts. ( 31061059 )
2019
2
Malondialdehyde-Acetaldehyde Adducts and Antibody Responses in Rheumatoid Arthritis-Interstitial Lung Disease. ( 30933423 )
2019
3
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. ( 30710005 )
2019
4
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. ( 30442831 )
2019
5
Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease. ( 29422289 )
2018
6
Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy? ( 30874239 )
2018
7
Practical Approach to the Evaluation and Management of Rheumatoid Arthritis-Interstitial Lung Disease Based on its Proven and Hypothetical Mechanisms. ( 29077694 )
2017
8
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis. ( 28495692 )
2017
9
Rheumatoid lung nodulosis during anti-TNF therapy. ( 28038860 )
2017
10
NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung. ( 26743485 )
2016
11
Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. ( 25822095 )
2015
12
Rheumatoid lung. ( 25956496 )
2015
13
Rheumatoid lung nodule. ( 26516255 )
2015
14
Rheumatoid arthritis interstitial lung disease: time to take notice. ( 24703236 )
2014
15
Diagnostic performances of high resolution trans-thoracic lung ultrasonography in pulmonary alveoli-interstitial involvement of rheumatoid lung disease. ( 23936595 )
2013
16
Smoking-related emphysema is associated with idiopathic pulmonary fibrosis and rheumatoid lung. ( 23819865 )
2013
17
Role of (18)F-FDG PET Scan in Rheumatoid Lung Nodule: Case Report and Review of the Literature. ( 23984160 )
2013
18
Rheumatoid lung disease: prognostic analysis of 54 biopsy-proven cases. ( 22560113 )
2012
19
Rheumatoid arthritis-interstitial lung disease-associated mortality. ( 20851924 )
2011
20
Rheumatoid arthritis interstitial lung disease: mycophenolate mofetil as an antifibrotic and disease-modifying antirheumatic drug. ( 18695091 )
2008
21
Massive spontaneous hemopneumothorax complicating rheumatoid lung disease. ( 17383372 )
2007
22
Multiple calcified pulmonary nodules: an unusual presentation of rheumatoid lung. ( 17293222 )
2007
23
Rheumatoid lung disease. ( 17684286 )
2007
24
Rheumatoid lung disease as seen on PET/CT scan. ( 17710040 )
2007
25
Acute progression of interstitial lung disease: a complication of etanercept particularly in the presence of rheumatoid lung and methotrexate treatment. ( 16760195 )
2006
26
Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. ( 16211338 )
2006
27
Methotrexate and the rheumatoid lung: a riddle wrapped in an enigma. ( 14593492 )
2004
28
Role of KL-6 in evaluating the disease severity of rheumatoid lung disease: comparison with HRCT. ( 15526815 )
2004
29
Rheumatoid lung nodules with hydropneumothorax. ( 14563474 )
2003
30
Gold-induced pulmonary disease: clinical features, outcome, and differentiation from rheumatoid lung disease. ( 9116980 )
1997
31
Cellular basis for elevated gallium-67 uptake in rheumatoid lung patient. ( 8429361 )
1993
32
Rheumatoid arthritis: classical rheumatoid lung disease. ( 8519069 )
1993
33
Rheumatoid arthritis: other rheumatoid lung problems. ( 8519073 )
1993
34
Cellular basis for the elevated gallium-67 computed lung index in a rheumatoid lung patient. ( 1744719 )
1991
35
Bronchoalveolar lavage in patients with mild and severe rheumatoid lung disease. ( 2169654 )
1990
36
Unilateral recurrent pneumothorax complicating rheumatoid lung. ( 2600437 )
1989
37
Spontaneous pneumothorax complicating rheumatoid lung disease. ( 2638671 )
1989
38
Rheumatoid arthritis presenting as arthritis mutilans with rheumatoid lung. ( 3379317 )
1988
39
Rheumatoid lung cavitation and response to penicillamine. ( 3501905 )
1987
40
CT appearances of rheumatoid lung disease. ( 6470256 )
1984
41
Bilateral pneumothoraces and pleural effusions in rheumatoid lung disease. ( 6710432 )
1984
42
Bilateral pneumothoraces and pleural effusions complicating rheumatoid lung disease. ( 6857576 )
1983
43
Rheumatoid lung disease, pneumothorax, and eosinophilia. ( 7073341 )
1982
44
Broncho-pleural fistula complicating rheumatoid lung disease. ( 7100049 )
1982
45
Rheumatoid lung disease. (A clinical, physiological and histological study in 33 patients). ( 7209294 )
1980
46
The case of the rheumatoid lung. ( 7399469 )
1980
47
Carcinoma of the colon presenting as rheumatoid lung. ( 7426290 )
1980
48
Bronchiolitis obliterans. A new form of rheumatoid lung? ( 620595 )
1978
49
Cavitary pulmonary lymphosarcoma masquerading as rheumatoid lung disease. ( 1083917 )
1976
50
Roentgenogram of the month. Productive cough and hemoptysis in rheumatoid lung disease. ( 1269277 )
1976

Variations for Rheumatoid Arthritis Interstitial Lung Disease

Expression for Rheumatoid Arthritis Interstitial Lung Disease

Search GEO for disease gene expression data for Rheumatoid Arthritis Interstitial Lung Disease.

Pathways for Rheumatoid Arthritis Interstitial Lung Disease

GO Terms for Rheumatoid Arthritis Interstitial Lung Disease

Cellular components related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CCL18 CEL IL17A IL1RN MMP3 MUC1
2 extracellular region GO:0005576 9.28 CCL18 CEL IL17A IL1RN MMP3 MUC1

Biological processes related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.71 CCL18 IL17A IL1RN TNF
2 immune response GO:0006955 9.65 CCL18 IL17A IL1RN TNF TNFRSF1B
3 cellular response to lipopolysaccharide GO:0071222 9.61 IL1RN TNF TNFRSF1B
4 positive regulation of osteoclast differentiation GO:0045672 9.37 IL17A TNF
5 inflammatory response GO:0006954 9.35 CCL18 IL17A IL1RN TNF TNFRSF1B
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.32 TNF TNFRSF1B
7 cytokine-mediated signaling pathway GO:0019221 9.1 IL17A IL1RN MMP3 MUC1 TNF TNFRSF1B
8 chronic inflammatory response to antigenic stimulus GO:0002439 8.85 TNF

Molecular functions related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL18 IL17A IL1RN TNF

Sources for Rheumatoid Arthritis Interstitial Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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