MCID: RHM036
MIFTS: 39

Rheumatoid Arthritis Interstitial Lung Disease

Categories: Bone diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Arthritis Interstitial Lung Disease

MalaCards integrated aliases for Rheumatoid Arthritis Interstitial Lung Disease:

Name: Rheumatoid Arthritis Interstitial Lung Disease 12 15
Rheumatoid Lung 12

Classifications:



External Ids:

Disease Ontology 12 DOID:849
ICD9CM 35 714.81
ICD10 33 J99.0 M05.1

Summaries for Rheumatoid Arthritis Interstitial Lung Disease

Disease Ontology : 12 An interstitial lung disease that is characterized by the development of pleuroparenchymal disease secondary to rheumatoid arthritis, including pleural effusions, pleural fibrosis, pulmonary vascular disease, and airway complications.

MalaCards based summary : Rheumatoid Arthritis Interstitial Lung Disease, also known as rheumatoid lung, is related to interstitial lung disease and arthritis. An important gene associated with Rheumatoid Arthritis Interstitial Lung Disease is CEL (Carboxyl Ester Lipase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and lymph node, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Rheumatoid Arthritis Interstitial Lung Disease

Diseases related to Rheumatoid Arthritis Interstitial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 interstitial lung disease 30.8 TNF SFTPD MUC1
2 arthritis 30.3 TNFRSF1B TNF MMP3 IL1RN
3 rheumatoid arthritis 30.1 TNFRSF1B TNF MMP3 IL1RN CD40LG
4 vasculitis 30.0 TNFRSF1B TNF CD40LG
5 exanthem 29.6 TNFRSF1B TNF IL1RN
6 pneumonia 29.5 TNF SFTPD CD40LG
7 connective tissue disease 29.5 TNF SFTPD MUC1 CD40LG
8 pulmonary fibrosis, idiopathic 29.0 TNF SFTPD MUC1 IL1RN CCL18
9 lung disease 10.6
10 chronic orbital inflammation 10.4 TNFRSF1B MUC1
11 chondromalacia 10.4 TNFRSF1B IL1RN
12 meningeal melanocytoma 10.4 MUC1 CD40LG
13 pleuroparenchymal fibroelastosis 10.4 SFTPD MUC1
14 chickenpox 10.4 TNFRSF1B MUC1
15 reticulum cell sarcoma 10.4 MUC1 CD4
16 acute interstitial pneumonia 10.3 SFTPD MUC1
17 hydrarthrosis 10.3 MMP3 IL1RN
18 vulvar vestibulitis syndrome 10.3 TNF IL1RN
19 idiopathic interstitial pneumonia 10.3
20 pulmonary fibrosis 10.3
21 skin sarcoidosis 10.3 TNFRSF1B TNF
22 ventilation pneumonitis 10.3 TNF CD4
23 osteosclerotic myeloma 10.3 TNF IL1RN
24 granulomatous dermatitis 10.3 TNFRSF1B TNF
25 chronic gonococcal salpingitis 10.3 TNFRSF1B TNF
26 peroneal neuropathy 10.3 TNFRSF1B TNF
27 anterior scleritis 10.2 TNFRSF1B IL1RN
28 chronic graft versus host disease 10.2 TNF CD4
29 periodic fever, familial, autosomal dominant 10.2 TNFRSF1B TNF
30 acute salpingitis 10.2 TNFRSF1B TNF
31 chronic salpingitis 10.2 TNFRSF1B TNF
32 post-transplant lymphoproliferative disease 10.2 TNFRSF1B TNF
33 pustulosis palmaris et plantaris 10.1 TNF CD40LG
34 aseptic meningitis 10.1 TNF IL1RN
35 synovitis 10.1 TNF MMP3 IL1RN
36 idiopathic neutropenia 10.1 TNF IL1RN CD40LG
37 brucellosis 10.1 TNF IL1RN CD40LG
38 juvenile ankylosing spondylitis 10.1 TNFRSF1B TNF IL1RN
39 spondylitis 10.1 TNFRSF1B TNF IL1RN
40 pustulosis of palm and sole 10.1 TNFRSF1B TNF IL1RN
41 scleral disease 10.1 TNFRSF1B TNF IL1RN
42 spondyloarthropathy 1 10.1 TNFRSF1B TNF MMP3
43 hypersensitivity reaction type iv disease 10.1 TNFRSF1B TNF IL1RN
44 exanthema subitum 10.1 TNFRSF1B CD40LG
45 juvenile rheumatoid arthritis 10.0 TNFRSF1B TNF IL1RN
46 fibrosis of extraocular muscles, congenital, 1 10.0
47 interstitial pneumonitis, desquamative, familial 10.0
48 acute sensory ataxic neuropathy 10.0
49 combined pulmonary fibrosis-emphysema syndrome 10.0
50 pneumothorax 10.0

Graphical network of the top 20 diseases related to Rheumatoid Arthritis Interstitial Lung Disease:



Diseases related to Rheumatoid Arthritis Interstitial Lung Disease

Symptoms & Phenotypes for Rheumatoid Arthritis Interstitial Lung Disease

MGI Mouse Phenotypes related to Rheumatoid Arthritis Interstitial Lung Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.86 CAV1 CD4 CD40LG IL1RN MMP3 SFTPD
2 homeostasis/metabolism MP:0005376 9.81 CAV1 CD4 CD40LG CEL IL1RN MMP3
3 immune system MP:0005387 9.56 CAV1 CD4 CD40LG IL1RN MMP3 SFTPD
4 integument MP:0010771 9.1 CAV1 CD4 CD40LG IL1RN TNF TNFRSF1B

Drugs & Therapeutics for Rheumatoid Arthritis Interstitial Lung Disease

Drugs for Rheumatoid Arthritis Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 2 1401-55-4
2
Benzocaine Approved, Investigational Phase 2 94-09-7, 1994-09-7 2337
3
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
4
Abatacept Approved Phase 2 332348-12-6 10237
5 Anesthetics, Local Phase 2
6 Central Nervous System Depressants Phase 2
7 Anesthetics Phase 2
8 Analgesics, Non-Narcotic Phase 2
9 Analgesics Phase 2
10 Anti-Inflammatory Agents, Non-Steroidal Phase 2
11 Anti-Inflammatory Agents Phase 2
12 Peripheral Nervous System Agents Phase 2
13 Antirheumatic Agents Phase 2
14 Immunologic Factors Phase 2
15 Immunosuppressive Agents Phase 2
16
Carbon monoxide Approved, Investigational 630-08-0 281
17 Alpha 1-Antitrypsin
18
protease inhibitors
19 HIV Protease Inhibitors
20 Antibodies
21 Immunoglobulins
22 Neurotransmitter Agents
23 Antimetabolites

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 AAFA™ Fish Oil Nutritional Supplementation to Maintain Body Weight in Patients With Disease-Related Weight Loss Completed NCT00094562 Phase 2 Fish oil supplement
2 Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients With Rheumatoid Arthritis Interstitial Lung Disease (TRAIL1) Recruiting NCT02808871 Phase 2 Pirfenidone;Placebo
3 Safety of Abatacept in Rheumatoid Arthritis Associated Interstitial Lung Disease: A Feasibility Trial Recruiting NCT03084419 Phase 2 Abatacept
4 A Randomized, Open Label, 4 Period Crossover Study in Healthy Subjects to Determine the Effect of Particle Size on the Pharmacokinetics of a Single mg Dose of GW856553 Completed NCT00517543 Phase 1 GW856553
5 Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis: Effect of Duration of Disease Unknown status NCT01641705
6 Fibrocytes in Rheumatoid Arthritis, Asthma and Interstitial Lung-disease. Completed NCT02711657
7 Pulmonary Fibrosis Associated With Rheumatoid Arthritis: Identification of Genetic Polymorphisms Completed NCT00001885
8 Pulmonary Fibrosis Associated With Rheumatoid Arthritis: Definition of the Natural History of Disease Completed NCT00001876
9 Investigating the Impact of Mode of Administration on Item Response Completed NCT00783991
10 Interstitial Lung Disease in Early Rheumatoid Arthritis Recruiting NCT03977415
11 Change in Serum and Sputum Biomarkers Over Time in the Development of Rheumatoid Arthritis-associated Lung Disease Recruiting NCT03616158
12 Rheumatoid Arthritis Patients at Risk for Interstitial Lung Disease Recruiting NCT03297775
13 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826
14 Treatment Outcome and Prognostic Factors for RA Patients With Interstitial Lung Disease Recruiting NCT03099525
15 Early Rheumatoid Arthritis Lung Disease Study Recruiting NCT03192267
16 Collection of Airway, Blood and/or Urine Specimens From Subjects for Research Studies Recruiting NCT01776398
17 EMPOWER-1: A Multi-site Clinical Cohort Study to Reduce Health Inequality: Identifying Ethnic Disparities in Treatment Failures for Medicines Prescribed to Treat Diseases That Cause Significant Mortality and Morbidity in the UK Population Not yet recruiting NCT03987633
18 Factors of ILD in Newly Diagnosed Rheumatoid Arthritis Not yet recruiting NCT04002765

Search NIH Clinical Center for Rheumatoid Arthritis Interstitial Lung Disease

Genetic Tests for Rheumatoid Arthritis Interstitial Lung Disease

Anatomical Context for Rheumatoid Arthritis Interstitial Lung Disease

MalaCards organs/tissues related to Rheumatoid Arthritis Interstitial Lung Disease:

41
Lung, Colon, Lymph Node, Neutrophil

Publications for Rheumatoid Arthritis Interstitial Lung Disease

Articles related to Rheumatoid Arthritis Interstitial Lung Disease:

(show top 50) (show all 181)
# Title Authors PMID Year
1
Is incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts. 38
31061059 2019
2
Pulmonary Complications of Rheumatoid Arthritis. 38
31137060 2019
3
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. 38
30442831 2019
4
Rheumatoid pulmonary nodules: clinical and imaging features compared with malignancy. 38
30288558 2019
5
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. 38
30710005 2019
6
Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy? 38
30874239 2018
7
Autoinflammatory disease in the lung. 38
29676014 2018
8
Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease. 38
29422289 2018
9
[Senile rheumatoid arthritis associated with rheumatoid lung: a caricatural observation]. 38
30627314 2018
10
Practical Approach to the Evaluation and Management of Rheumatoid Arthritis-Interstitial Lung Disease Based on its Proven and Hypothetical Mechanisms. 38
29077694 2017
11
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis. 38
28495692 2017
12
[The 456th case: polyarthritis, dry cough, dyspnea on exertion]. 38
28460514 2017
13
Rheumatoid lung nodulosis during anti-TNF therapy. 38
28038860 2017
14
The relationship of SSRI and SNRI usage with interstitial lung disease and bronchiectasis in an elderly population: a case-control study. 38
29200837 2017
15
NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung. 38
26743485 2016
16
An interesting finding of multiple calcified pulmonary nodules in a patient with rheumatoid arthritis. 38
30364404 2016
17
An Autopsy Case of Fulminant Amebic Colitis in a Patient with a History of Rheumatoid Arthritis. 38
27382497 2016
18
Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model. 38
26881215 2016
19
Rheumatoid lung nodule. 38
26516255 2015
20
Rheumatoid Arthritis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: Shared Mechanistic and Phenotypic Traits Suggest Overlapping Disease Mechanisms. 38
26696331 2015
21
Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. 38
25822095 2015
22
Rheumatoid lung. 38
25956496 2015
23
Idiopathic pleuroparenchymal fibroelastosis presenting in recurrent pneumothorax: a case report. 38
25368665 2014
24
Rheumatoid arthritis interstitial lung disease: time to take notice. 38
24703236 2014
25
[Pathogenesis of rheumatoid arthritis]. 38
25427390 2014
26
Smoking-related emphysema is associated with idiopathic pulmonary fibrosis and rheumatoid lung. 38
23819865 2013
27
Rituximab: rescue therapy in life-threatening complications or refractory autoimmune diseases: a single center experience. 38
23239037 2013
28
A rheumatoid nodule in an unusual location: mediastinal lymph node. 38
23645652 2013
29
Acute exacerbations of idiopathic pulmonary fibrosis. 38
24157720 2013
30
Progressive intraparenchymal lung nodules dissemination in a heavy smoker and seropositive rheumatoid arthritis suspected of tuberculosis relapse. 38
24068421 2013
31
Role of (18)F-FDG PET Scan in Rheumatoid Lung Nodule: Case Report and Review of the Literature. 38
23984160 2013
32
Diagnostic performances of high resolution trans-thoracic lung ultrasonography in pulmonary alveoli-interstitial involvement of rheumatoid lung disease. 38
23936595 2013
33
Chronic inflammation and lung fibrosis: pleotropic syndromes but limited distinct phenotypes. 38
22806097 2012
34
Rheumatoid lung disease: prognostic analysis of 54 biopsy-proven cases. 38
22560113 2012
35
[Intrathoracic lymphadenopathy: an unusual manifestation of rheumatoid arthritis]. 38
22305139 2012
36
Intracellular detection of interleukin 17 and other cytokines in human bronchoalveolar lavage fluid: a first assessment. 38
22020264 2012
37
[Interstitial pneumonia with anti-PL-7 antibody difficult to distinguish from rheumatoid lung]. 38
22117318 2011
38
Rheumatoid nodule and combined pulmonary carcinoma: topographic correlations; a case report and review of the literature. 38
21210348 2011
39
Rheumatoid arthritis-interstitial lung disease-associated mortality. 38
20851924 2011
40
Rheumatoid arthritis: spectrum of computed tomographic findings in pulmonary diseases. 38
20875611 2010
41
Adalimumab-induced acute pneumonitis in a patient with rheumatoid arthritis. 38
20511978 2010
42
[Rheumatoid arthritis diagnosis based on the detection of a pulmonary rheumatoid nodule in a patient with Hansen's disease]. 38
20163026 2010
43
[A case of rheumatoid arthritis with pneumothorax due to subpleural pulmonary rheumatoid nodules]. 38
19068769 2008
44
Rheumatoid arthritis interstitial lung disease: mycophenolate mofetil as an antifibrotic and disease-modifying antirheumatic drug. 38
18695091 2008
45
Rheumatoid lung disease as seen on PET/CT scan. 38
17710040 2007
46
Rheumatoid lung disease. 38
17684286 2007
47
Massive spontaneous hemopneumothorax complicating rheumatoid lung disease. 38
17383372 2007
48
Multiple calcified pulmonary nodules: an unusual presentation of rheumatoid lung. 38
17293222 2007
49
[A case of rheumatoid lung complicated by SELAPINA-induced pneumonia]. 38
17144587 2006
50
Acute progression of interstitial lung disease: a complication of etanercept particularly in the presence of rheumatoid lung and methotrexate treatment. 38
16760195 2006

Variations for Rheumatoid Arthritis Interstitial Lung Disease

Expression for Rheumatoid Arthritis Interstitial Lung Disease

Search GEO for disease gene expression data for Rheumatoid Arthritis Interstitial Lung Disease.

Pathways for Rheumatoid Arthritis Interstitial Lung Disease

Pathways related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 TNFRSF1B TNF MUC1 MMP3 IL1RN CD40LG
2
Show member pathways
12.54 TNFRSF1B TNF CD40LG CD4 CAV1
3
Show member pathways
12.41 TNFRSF1B TNF CD40LG CD4
4
Show member pathways
12.35 TNFRSF1B TNF CD40LG CD4
5 12.25 TNFRSF1B TNF IL1RN CD40LG
6 11.98 TNFRSF1B TNF CD40LG
7
Show member pathways
11.92 TNF SFTPD MUC1
8 11.74 MUC1 MMP3 CAV1
9 11.68 TNFRSF1B TNF MMP3
10
Show member pathways
11.41 TNFRSF1B TNF CD40LG
11 11.31 TNFRSF1B TNF MUC1 MMP3
12
Show member pathways
11.3 TNF MMP3 CD40LG
13 11.12 TNFRSF1B TNF IL1RN
14 11.09 TNFRSF1B CD40LG
15 11.07 TNFRSF1B TNF
16 11.01 TNF CD4
17 10.96 TNF CD40LG CCL18
18 10.78 TNF MMP3 IL1RN CCL18

GO Terms for Rheumatoid Arthritis Interstitial Lung Disease

Cellular components related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.73 TNF MUC1 CEL CD40LG CD4 CAV1
2 extracellular space GO:0005615 9.56 TNF SFTPD MUC1 MMP3 IL1RN CEL
3 membrane raft GO:0045121 9.46 TNFRSF1B TNF CD4 CAV1
4 extracellular region GO:0005576 9.28 TNFRSF1B TNF SFTPD MUC1 MMP3 IL1RN

Biological processes related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.67 TNF IL1RN CD4
2 cellular response to lipopolysaccharide GO:0071222 9.65 TNFRSF1B TNF IL1RN
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.58 TNFRSF1B TNF CD40LG
4 inflammatory response GO:0006954 9.55 TNFRSF1B TNF IL1RN CD40LG CCL18
5 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 TNFRSF1B TNF
6 positive regulation of calcium ion transport into cytosol GO:0010524 9.43 CD4 CAV1
7 immune response GO:0006955 9.43 TNFRSF1B TNF IL1RN CD40LG CD4 CCL18
8 regulation of immunoglobulin secretion GO:0051023 9.37 TNF CD40LG
9 maintenance of protein location in cell GO:0032507 9.32 CD4 CAV1
10 cytokine-mediated signaling pathway GO:0019221 9.1 TNFRSF1B TNF MUC1 MMP3 IL1RN CD4
11 chronic inflammatory response to antigenic stimulus GO:0002439 8.96 TNF

Molecular functions related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.96 TNF CD40LG
2 cytokine activity GO:0005125 8.92 TNF IL1RN CD40LG CCL18

Sources for Rheumatoid Arthritis Interstitial Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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