MCID: RHM036
MIFTS: 36

Rheumatoid Arthritis Interstitial Lung Disease

Categories: Bone diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Arthritis Interstitial Lung Disease

Summaries for Rheumatoid Arthritis Interstitial Lung Disease

Disease Ontology : 12 An interstitial lung disease that is characterized by the development of pleuroparenchymal disease secondary to rheumatoid arthritis, including pleural effusions, pleural fibrosis, pulmonary vascular disease, and airway complications.

MalaCards based summary : Rheumatoid Arthritis Interstitial Lung Disease, also known as rheumatoid lung, is related to interstitial lung disease and lung disease. An important gene associated with Rheumatoid Arthritis Interstitial Lung Disease is CEL (Carboxyl Ester Lipase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. The drugs Pirfenidone and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include lung and colon, and related phenotype is homeostasis/metabolism.

Related Diseases for Rheumatoid Arthritis Interstitial Lung Disease

Diseases related to Rheumatoid Arthritis Interstitial Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 interstitial lung disease 30.9 MUC1 SFTPD TNF
2 lung disease 30.7 IL17A SFTPD TNF
3 arthritis 30.3 IL17A IL1RN MMP3 TNF TNFRSF1B
4 rheumatoid arthritis 30.3 IL17A IL1RN MMP3 TNF TNFRSF1B
5 pulmonary fibrosis, idiopathic 29.0 CCL18 IL1RN MUC1 SFTPD TNF
6 rectum squamous cell carcinoma 10.3 SMUG1 TNFRSF1B
7 pleuroparenchymal fibroelastosis 10.3 MUC1 SFTPD
8 chronic orbital inflammation 10.3 MUC1 TNFRSF1B
9 cartilage disease 10.3 IL1RN SMUG1
10 acute interstitial pneumonia 10.3 MUC1 SFTPD
11 vulvar vestibulitis syndrome 10.3 IL1RN TNF
12 granulomatous myositis 10.3 SMUG1 TNFRSF1B
13 skin sarcoidosis 10.2 TNF TNFRSF1B
14 pericardium disease 10.2 IL1RN SMUG1
15 osteosclerotic myeloma 10.2 IL1RN TNF
16 chronic gonococcal salpingitis 10.2 TNF TNFRSF1B
17 cardiac sarcoidosis 10.2 SMUG1 TNF
18 granulomatous dermatitis 10.2 TNF TNFRSF1B
19 peroneal neuropathy 10.2 TNF TNFRSF1B
20 tuberculous peritonitis 10.2 SMUG1 TNF
21 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
22 filamentary keratitis 10.2 IL17A MUC1
23 acute salpingitis 10.2 TNF TNFRSF1B
24 pulmonary alveolar microlithiasis 10.2 SFTPD SMUG1
25 chickenpox 10.2 MUC1 TNFRSF1B
26 hydrarthrosis 10.2 IL1RN MMP3
27 post-transplant lymphoproliferative disease 10.2 TNF TNFRSF1B
28 trichosporonosis 10.1 IL17A TNF
29 anterior scleritis 10.1 IL1RN TNFRSF1B
30 nasopharyngitis 10.1 IL17A TNFRSF1B
31 chondromalacia 10.1 IL1RN SMUG1 TNFRSF1B
32 chronic salpingitis 10.1 TNF TNFRSF1B
33 synovitis 10.1 IL1RN MMP3 TNF
34 temporal arteritis 10.1 IL1RN SMUG1 TNF
35 juvenile ankylosing spondylitis 10.1 IL1RN TNF TNFRSF1B
36 scleral disease 10.1 IL1RN TNF TNFRSF1B
37 pustulosis of palm and sole 10.1 IL1RN TNF TNFRSF1B
38 autoimmune disease of eyes, ear, nose and throat 10.1 IL17A TNF
39 transverse myelitis 10.1 IL17A TNF
40 exanthem 10.1 IL1RN TNF TNFRSF1B
41 myelitis 10.1 IL17A TNF
42 juvenile rheumatoid arthritis 10.1 IL1RN TNF TNFRSF1B
43 cogan syndrome 10.1 SMUG1 TNF TNFRSF1B
44 primary systemic mycosis 10.1 IL17A TNF
45 pneumocystosis 10.1 MUC1 SFTPD TNF
46 mycoplasma pneumoniae pneumonia 10.0 IL17A TNF
47 aseptic meningitis 10.0 IL1RN TNF
48 silicosis 10.0 IL1RN SFTPD TNF
49 spondyloarthropathy 10.0 IL17A MMP3 TNF
50 pulmonary fibrosis 10.0

Graphical network of the top 20 diseases related to Rheumatoid Arthritis Interstitial Lung Disease:



Diseases related to Rheumatoid Arthritis Interstitial Lung Disease

Symptoms & Phenotypes for Rheumatoid Arthritis Interstitial Lung Disease

MGI Mouse Phenotypes related to Rheumatoid Arthritis Interstitial Lung Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.28 CAV1 CEL IL17A IL1RN MMP3 SFTPD

Drugs & Therapeutics for Rheumatoid Arthritis Interstitial Lung Disease

Drugs for Rheumatoid Arthritis Interstitial Lung Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
2 Anti-Inflammatory Agents Phase 2
3 Antirheumatic Agents Phase 2
4 Analgesics Phase 2
5 Anti-Inflammatory Agents, Non-Steroidal Phase 2
6 Peripheral Nervous System Agents Phase 2
7 Analgesics, Non-Narcotic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase ll Study of Pirfenidone in Patients With RAILD (TRAIL1) Recruiting NCT02808871 Phase 2 Pirfenidone;Placebo
2 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Active Rheumatoid Arthritis Terminated NCT01261403 Phase 2 Vehicle Controlled Placebo
3 Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis Unknown status NCT01641705
4 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826

Search NIH Clinical Center for Rheumatoid Arthritis Interstitial Lung Disease

Genetic Tests for Rheumatoid Arthritis Interstitial Lung Disease

Anatomical Context for Rheumatoid Arthritis Interstitial Lung Disease

MalaCards organs/tissues related to Rheumatoid Arthritis Interstitial Lung Disease:

42
Lung, Colon

Publications for Rheumatoid Arthritis Interstitial Lung Disease

Articles related to Rheumatoid Arthritis Interstitial Lung Disease:

(show all 34)
# Title Authors Year
1
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. ( 30710005 )
2019
2
Prevalence and Effects of Emphysema in Never-Smokers with Rheumatoid Arthritis Interstitial Lung Disease. ( 29422289 )
2018
3
Rheumatoid Arthritis-Interstitial Lung Disease in the United States: Prevalence, Incidence, and Healthcare Costs and Mortality. ( 30442831 )
2018
4
Tumor-Associated Antigens in Rheumatoid Arthritis Interstitial Lung Disease or Malignancy? ( 30874239 )
2018
5
Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis. ( 28495692 )
2017
6
Practical Approach to the Evaluation and Management of Rheumatoid Arthritis-Interstitial Lung Disease Based on its Proven and Hypothetical Mechanisms. ( 29077694 )
2017
7
Rheumatoid lung nodulosis during anti-TNF therapy. ( 28038860 )
2017
8
Detection of Rheumatoid Arthritis-Interstitial Lung Disease is Enhanced by Serum Biomarkers. ( 25822095 )
2015
9
Rheumatoid lung. ( 25956496 )
2015
10
Rheumatoid lung nodule. ( 26516255 )
2015
11
Rheumatoid arthritis interstitial lung disease: time to take notice. ( 24703236 )
2014
12
Role of (18)F-FDG PET Scan in Rheumatoid Lung Nodule: Case Report and Review of the Literature. ( 23984160 )
2013
13
Rheumatoid arthritis-interstitial lung disease-associated mortality. ( 20851924 )
2011
14
Rheumatoid arthritis interstitial lung disease: mycophenolate mofetil as an antifibrotic and disease-modifying antirheumatic drug. ( 18695091 )
2008
15
Multiple calcified pulmonary nodules: an unusual presentation of rheumatoid lung. ( 17293222 )
2007
16
Acute progression of interstitial lung disease: a complication of etanercept particularly in the presence of rheumatoid lung and methotrexate treatment. ( 16760195 )
2006
17
Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. ( 16211338 )
2006
18
Methotrexate and the rheumatoid lung: a riddle wrapped in an enigma. ( 14593492 )
2004
19
Rheumatoid lung nodules with hydropneumothorax. ( 14563474 )
2003
20
Cellular basis for elevated gallium-67 uptake in rheumatoid lung patient. ( 8429361 )
1993
21
Rheumatoid arthritis: other rheumatoid lung problems. ( 8519073 )
1993
22
Unilateral recurrent pneumothorax complicating rheumatoid lung. ( 2600437 )
1989
23
Rheumatoid arthritis presenting as arthritis mutilans with rheumatoid lung. ( 3379317 )
1988
24
Rheumatoid lung cavitation and response to penicillamine. ( 3501905 )
1987
25
The case of the rheumatoid lung. ( 7399469 )
1980
26
Carcinoma of the colon presenting as rheumatoid lung. ( 7426290 )
1980
27
Bronchiolitis obliterans. A new form of rheumatoid lung? ( 620595 )
1978
28
Rheumatoid lung. ( 1205548 )
1975
29
Immunofluorescent and immunologic studies of rheumatoid lung. ( 4111725 )
1972
30
The five manifestations of rheumatoid lung. ( 5907805 )
1966
31
Rheumatoid lung. ( 13931185 )
1963
32
CAVITATION OF A RHEUMATOID LUNG NODULE. ( 14043582 )
1963
33
Case of Rheumatoid Lung with Cavity Formation. ( 20789642 )
1963
34
Rheumatoid lung changes associated with asbestosis. ( 13580972 )
1958

Variations for Rheumatoid Arthritis Interstitial Lung Disease

Expression for Rheumatoid Arthritis Interstitial Lung Disease

Search GEO for disease gene expression data for Rheumatoid Arthritis Interstitial Lung Disease.

Pathways for Rheumatoid Arthritis Interstitial Lung Disease

GO Terms for Rheumatoid Arthritis Interstitial Lung Disease

Cellular components related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CCL18 CEL IL17A IL1RN MMP3 MUC1
2 extracellular region GO:0005576 9.28 CCL18 CEL IL17A IL1RN MMP3 MUC1

Biological processes related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.71 CCL18 IL17A IL1RN TNF
2 immune response GO:0006955 9.65 CCL18 IL17A IL1RN TNF TNFRSF1B
3 cellular response to lipopolysaccharide GO:0071222 9.61 IL1RN TNF TNFRSF1B
4 positive regulation of osteoclast differentiation GO:0045672 9.37 IL17A TNF
5 inflammatory response GO:0006954 9.35 CCL18 IL17A IL1RN TNF TNFRSF1B
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.32 TNF TNFRSF1B
7 cytokine-mediated signaling pathway GO:0019221 9.1 IL17A IL1RN MMP3 MUC1 TNF TNFRSF1B
8 chronic inflammatory response to antigenic stimulus GO:0002439 8.85 TNF

Molecular functions related to Rheumatoid Arthritis Interstitial Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CCL18 IL17A IL1RN TNF

Sources for Rheumatoid Arthritis Interstitial Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....