MCID: RHM032
MIFTS: 17

Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

Name: Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis 20
Rheumatoid Factor Negative Erosive Chronic Polyarthritis 20
Juvenile Rheumatoid Factor-Negative Polyarthritis 20
Rheumatoid Factor-Negative Polyarthritis 20
Polyarthritis Without Rheumatoid Factor 20
Rheumatoid Factor-Negative Jia 20
Rf-Ve Cp 20

Classifications:



Summaries for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 85408 Definition Rheumatoid factor-negative polyarthritis is a term used to describe a group of poorly defined heterogenous conditions that incorporates forms of rheumatoid factor-negative polyarthritis and forms of oligoarticular arthritis that become extensive in less than 6 months after onset. Epidemiology Rheumatoid factor-negative polyarthritis represents around 15-20% of cases of juvenile idiopathic arthritis (JIA). Prevalence has been estimated at between 1 and 13 in 22,200 children, with an annual incidence of 1-26 in 700,000 children. Females are affected more often than males. Clinical description The joint manifestations are bilateral, nearly symmetrical and affect both the large and small joints. Biological signs of inflammatory disease are frequent. Rheumatoid factor tests are always negative but antinuclear antibodies may be present. Etiology The aetiology is difficult to determine as a result of the heterogeneity. Diagnostic methods The diagnostic criteria for the disease were established in 2001 at the last international meeting in Edmonton. Rheumatoid factor-negative polyarthritis is defined as the presence of arthritis affecting five or more joints at disease onset. Exclusion criteria are the presence of systemic arthritis or psoriasis in the patient, or a family history of psoriasis in one of the parents or a first-degree relative, HLA B27-positivity in males with onset of arthritis after 6 years of age, and detection of rheumatoid factor IgM in two test samples taken three months apart. Other exclusion criteria include: the presence of ankylosing spondylarthritis, enthesitis and arthritis, sacroiliitis with an inflammatory enteropathy or acute anterior uveitis in the patient, or a family history of one of these conditions in a parent or first-degree relative. Differential diagnosis The differential diagnosis should include other forms of polyarthritis (associated with inflammatory or haemato-oncologic diseases). Management and treatment Patients should be managed in a multidisciplinary manner, incorporating expertise in paediatric rheumatology, physiotherapy, psychologyand infantile orthopaedic care. Treatment is based on the association nonsteroidal anti-inflammatory agents (NSAIDS), disease-modifying antirheumatic drugs (methotrexate as a first-line treatment and tumour necrosis factor (TNF)-alpha as a second-line treatment) and rehabilitation. Corticotherapy is used at low doses and as rarely as possible. Intraarticular injection of delayed-action corticoids (triamcinolone hexacetonide) may be recommended in case of persistent arthritis. Prognosis The prognosis is difficult to determine due to the heterogeneity of the condition but it appears the percentage of remission is low.

MalaCards based summary : Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis, also known as rheumatoid factor negative erosive chronic polyarthritis, is related to arthritis and juvenile rheumatoid arthritis. An important gene associated with Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis is SLC11A1 (Solute Carrier Family 11 Member 1). Affiliated tissues include lung.

Related Diseases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Graphical network of the top 20 diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:



Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Drugs & Therapeutics for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search Clinical Trials , NIH Clinical Center for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Genetic Tests for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Anatomical Context for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

40
Lung

Publications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Articles related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

(show all 33)
# Title Authors PMID Year
1
[Methotrexate in juvenile idiopathic arthritis. Adverse effects and associated factors]. 61
31699619 2020
2
Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC). 61
31575380 2019
3
Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study. 61
30819662 2019
4
Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries. 61
30587248 2018
5
Baseline ultrasound examination as possible predictor of relapse in patients affected by juvenile idiopathic arthritis (JIA). 61
29437586 2018
6
Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication. 61
29717035 2018
7
Flares of Disease in Children with Clinically Inactive Juvenile Idiopathic Arthritis Were Not Correlated with Ultrasound Findings. 61
29606669 2018
8
Autoimmune Thrombotic Thrombocytopenic Purpura: Two Rare Cases Associated with Juvenile Idiopathic Arthritis and Multiple Sclerosis. 61
28791286 2017
9
Influence of past breast feeding on pattern and severity of presentation of juvenile idiopathic arthritis. 61
26369575 2016
10
A better understanding of juvenile idiopathic arthritis with classification criteria. 61
28049960 2016
11
No association of IL-12p40 pro1.1 polymorphism with juvenile idiopathic arthritis. 61
26667304 2015
12
Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis. 61
26179062 2015
13
Erythrocyte sedimentation rate as baseline predictor for the development of uveitis in children with juvenile idiopathic arthritis. 61
25447121 2015
14
Female sex and oligoarthritis category are not risk factors for uveitis in Italian children with juvenile idiopathic arthritis. 61
24931957 2014
15
Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis. 61
24347572 2014
16
Growth of children with juvenile idiopathic arthritis. 61
24736907 2014
17
MEFV gene mutations in Turkish children with juvenile idiopathic arthritis. 61
23588594 2013
18
Summary of AHRQ's Comparative Effectiveness Review of Disease-Modifying Antirheumatic Drugs for Children with Juvenile Idiopathic Arthritis. 61
22376227 2012
19
Antinuclear antibody-positive patients should be grouped as a separate category in the classification of juvenile idiopathic arthritis. 61
20936630 2011
20
Chronic eosinophilic pneumonia (Carrington's disease) and rheumatoid arthritis. 61
20627791 2010
21
[Juvenile idiopathic arthritis with dry synovitis: clinical case and review of literature]. 61
19820678 2009
22
Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis. 61
19248117 2009
23
The TRAF1/C5 region is a risk factor for polyarthritis in juvenile idiopathic arthritis. 61
18593758 2008
24
Partial C4 deficiency in juvenile idiopathic arthritis patients. 61
17921792 2007
25
Tumour necrosis factor alpha promoter polymorphisms and etanercept therapy in juvenile idiopathic arthritis. 61
16951943 2007
26
Tumor necrosis factor alpha promoter polymorphisms in patients with juvenile idiopathic arthritis. 61
16539828 2006
27
Course of joint disease in patients with antinuclear antibody-positive juvenile idiopathic arthritis. 61
16142881 2005
28
Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. 61
15641099 2005
29
Arthritis and uveitis in children. A pediatric rheumatology perspective. 61
12788129 2003
30
Evaluation of the ILAR criteria for juvenile idiopathic arthritis. 61
11708431 2001
31
Comparison of criteria for the classification of childhood arthritis. 61
10813302 2000
32
Chronic arthritis in children. Juvenile rheumatoid arthritis. 61
6607149 1984
33
HLA B27 in rheumatoid factor-negative polyarthritis. 61
869349 1977

Variations for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Expression for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis.

Pathways for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

GO Terms for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Cellular components related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosome GO:0005764 9.16 SLC11A1 HLA-DRB1
2 endosome membrane GO:0010008 8.96 SLC11A1 HLA-DRB1
3 late endosome membrane GO:0031902 8.62 SLC11A1 HLA-DRB1

Biological processes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 8.62 SLC11A1 HLA-DRB1

Sources for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....