MCID: RHM032
MIFTS: 37

Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Categories: Bone diseases, Eye diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

Name: Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis 60
Juvenile Rheumatoid Factor-Negative Polyarthritis 60
Polyarthritis Without Rheumatoid Factor 60
Rheumatoid Factor-Negative Jia 60

Characteristics:

Orphanet epidemiological data:

60
rheumatoid factor-negative juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy;

Classifications:



Summaries for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards based summary : Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis, also known as juvenile rheumatoid factor-negative polyarthritis, is related to arthritis and rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies. An important gene associated with Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis is IL2RB (Interleukin 2 Receptor Subunit Beta), and among its related pathways/superpathways are Innate Immune System and Th17 cell differentiation. Affiliated tissues include bone and eye, and related phenotypes are joint dislocation and dental malocclusion

Related Diseases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.0 HLA-DRB1 PTPN22 STAT4
2 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 12.7
3 rheumatoid factor-negative juvenile idiopathic arthritis with anti-nuclear antibodies 12.7
4 type 1 diabetes mellitus 12 10.3 HLA-DRB1 SLC11A1
5 nontuberculous mycobacterial lung disease 10.2 HLA-DRB1 SLC11A1
6 rheumatoid arthritis, systemic juvenile 10.2 HLA-DRB1 IL2RB
7 palindromic rheumatism 10.1 HLA-DRB1 PTPN22
8 pure red-cell aplasia 10.1 HLA-DRB1 IL2RA
9 temporal arteritis 10.1 HLA-DRB1 PTPN22
10 limited scleroderma 10.1 HLA-DRB1 IL2RA
11 idiopathic neutropenia 10.0 HLA-DRB1 IL2RA
12 brucellosis 10.0 IL2RA SLC11A1
13 b-cell expansion with nfkb and t-cell anergy 10.0 IL2RA IL2RB
14 mumps 10.0 HLA-DRB1 IL2RA
15 diffuse cutaneous systemic sclerosis 10.0 HLA-DRB1 STAT4
16 juvenile rheumatoid arthritis 9.9 HLA-DRB1 IL2RA SLC11A1
17 bone inflammation disease 9.9 HLA-DRB1 PTPN22
18 rheumatic disease 9.9 HLA-DRB1 IL2RA IL2RB
19 immune deficiency disease 9.9 IL2RA IL2RB
20 alopecia areata 9.9 IL2RA PTPN22
21 chronic mucocutaneous candidiasis 9.8 IL2RA PTPN22
22 vogt-koyanagi-harada disease 9.8 HLA-DRB1 IL2RA PTPN22
23 graves' disease 9.8 HLA-DRB1 IL2RA PTPN22
24 diabetes mellitus, insulin-dependent 9.8 HLA-DRB1 IL2RA PTPN22
25 autoimmune disease of musculoskeletal system 9.7 PTPN22 STAT4
26 sarcoidosis 1 9.7 HLA-DRB1 IL2RA IL2RB SLC11A1
27 sezary's disease 9.4 IL2RA STAT4
28 autoimmune disease 9.3 HLA-DRB1 IL2RA PTPN22 STAT4
29 rheumatoid arthritis 9.1 HLA-DRB1 IL2RA PTPN22 SLC11A1 STAT4
30 systemic lupus erythematosus 9.0 CD247 HLA-DRB1 IL2RA PTPN22 STAT4
31 oligoarticular juvenile idiopathic arthritis 8.3 ANKRD55 CD247 HLA-DRB1 IL2RA IL2RB PTPN2

Graphical network of the top 20 diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:



Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Human phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

60 33 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint dislocation 60 33 hallmark (90%) Very frequent (99-80%) HP:0001373
2 dental malocclusion 60 33 hallmark (90%) Very frequent (99-80%) HP:0000689
3 joint swelling 60 33 hallmark (90%) Very frequent (99-80%) HP:0001386
4 arthralgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002829
5 limitation of joint mobility 60 33 hallmark (90%) Very frequent (99-80%) HP:0001376
6 apraxia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002186
7 elevated c-reactive protein level 60 33 hallmark (90%) Very frequent (99-80%) HP:0011227
8 elevated erythrocyte sedimentation rate 60 33 hallmark (90%) Very frequent (99-80%) HP:0003565
9 antinuclear antibody positivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0003493
10 polyarticular arthritis 60 33 hallmark (90%) Very frequent (99-80%) HP:0005764
11 juvenile rheumatoid arthritis 60 33 hallmark (90%) Very frequent (99-80%) HP:0005681

MGI Mouse Phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.73 CD247 IL2RA IL2RB PTPN2 PTPN22 STAT4
2 hematopoietic system MP:0005397 9.7 CD247 IL2RA IL2RB PTPN2 PTPN22 SLC11A1
3 immune system MP:0005387 9.5 CD247 IL2RA IL2RB PTPN2 PTPN22 SLC11A1
4 mortality/aging MP:0010768 9.17 CD247 IL2RA IL2RB PTPN2 PTPN22 SLC11A1

Drugs & Therapeutics for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search Clinical Trials , NIH Clinical Center for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Genetic Tests for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Anatomical Context for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

42
Bone, Eye

Publications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Articles related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

# Title Authors Year
1
Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication. ( 29717035 )
2018
2
Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. ( 15641099 )
2005

Variations for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Expression for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis.

Pathways for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Pathways related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 CD247 HLA-DRB1 IL2RA IL2RB PTPN2 PTPN22
2
Show member pathways
12.26 CD247 HLA-DRB1 IL2RA IL2RB STAT4
3 12.17 IL2RA IL2RB PTPN2 PTPN22 STAT4
4
Show member pathways
12.12 IL2RA IL2RB PTPN2 STAT4
5
Show member pathways
12.09 CD247 HLA-DRB1 IL2RA IL2RB
6 12.07 HLA-DRB1 IL2RA IL2RB
7
Show member pathways
12.06 CD247 HLA-DRB1 PTPN22
8
Show member pathways
11.69 CD247 HLA-DRB1 PTPN22
9 11.62 IL2RA IL2RB STAT4
10 11.46 CD247 HLA-DRB1 PTPN22
11
Show member pathways
11.41 IL2RA IL2RB
12
Show member pathways
11.41 CD247 HLA-DRB1 IL2RA IL2RB STAT4
13 11.25 IL2RA STAT4
14
Show member pathways
11.24 CD247 IL2RA IL2RB STAT4
15 11.21 IL2RA IL2RB STAT4
16 11.17 PTPN2 STAT4
17 11.07 IL2RA IL2RB
18
Show member pathways
10.97 IL2RA STAT4
19 10.37 CD247 HLA-DRB1 IL2RA STAT4

GO Terms for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Cellular components related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 HLA-DRB1 IL2RA IL2RB

Biological processes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 CD247 HLA-DRB1 IL2RA PTPN22
2 cytokine-mediated signaling pathway GO:0019221 9.63 IL2RA IL2RB STAT4
3 negative regulation of T cell proliferation GO:0042130 9.43 HLA-DRB1 IL2RA
4 T cell receptor signaling pathway GO:0050852 9.43 CD247 HLA-DRB1 PTPN22
5 T cell differentiation GO:0030217 9.4 PTPN2 PTPN22
6 negative regulation of T cell receptor signaling pathway GO:0050860 9.32 PTPN2 PTPN22
7 inflammatory response to antigenic stimulus GO:0002437 9.16 HLA-DRB1 IL2RA
8 interleukin-2-mediated signaling pathway GO:0038110 8.96 IL2RA IL2RB
9 interleukin-2 production GO:0032623 8.62 CD247 SLC11A1

Molecular functions related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.16 CD247 PTPN22
2 interleukin-2 binding GO:0019976 8.96 IL2RA IL2RB
3 interleukin-2 receptor activity GO:0004911 8.62 IL2RA IL2RB

Sources for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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