MCID: RHM032
MIFTS: 36

Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Categories: Eye diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards integrated aliases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

Name: Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis 59
Juvenile Rheumatoid Factor-Negative Polyarthritis 59
Polyarthritis Without Rheumatoid Factor 59
Rheumatoid Factor-Negative Jia 59

Characteristics:

Orphanet epidemiological data:

59
rheumatoid factor-negative juvenile idiopathic arthritis
Inheritance: Multigenic/multifactorial; Age of death: normal life expectancy;

Classifications:



Summaries for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards based summary : Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis, also known as juvenile rheumatoid factor-negative polyarthritis, is related to arthritis and rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies. An important gene associated with Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis is PTPN2 (Protein Tyrosine Phosphatase, Non-Receptor Type 2), and among its related pathways/superpathways are Innate Immune System and Regulation of IFNA signaling. Affiliated tissues include bone and eye, and related phenotypes are joint dislocation and dental malocclusion

Related Diseases for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 arthritis 29.9 HLA-DRB1 PTPN22 STAT4
2 rheumatoid factor-negative juvenile idiopathic arthritis without anti-nuclear antibodies 12.5
3 rheumatoid factor-negative juvenile idiopathic arthritis with anti-nuclear antibodies 12.5
4 type 1 diabetes mellitus 12 10.6 HLA-DRB1 SLC11A1
5 nontuberculous mycobacterial lung disease 10.5 HLA-DRB1 SLC11A1
6 autoimmune addison disease 10.5 HLA-DRB1 PTPN22
7 diffuse cutaneous systemic sclerosis 10.3 HLA-DRB1 STAT4
8 palindromic rheumatism 10.3 HLA-DRB1 PTPN22
9 rheumatoid arthritis, systemic juvenile 10.3 HLA-DRB1 IL2RB
10 pure red-cell aplasia 10.2 HLA-DRB1 IL2RA
11 temporal arteritis 10.2 HLA-DRB1 PTPN22
12 anterior uveitis 10.1 IL2RA PTPN22
13 limited scleroderma 10.1 HLA-DRB1 IL2RA
14 bone inflammation disease 10.1 HLA-DRB1 PTPN22
15 idiopathic neutropenia 10.0 HLA-DRB1 IL2RA
16 brucellosis 9.9 IL2RA SLC11A1
17 juvenile rheumatoid arthritis 9.8 HLA-DRB1 IL2RA SLC11A1
18 sarcoidosis 1 9.8 HLA-DRB1 IL2RA SLC11A1
19 vogt-koyanagi-harada disease 9.8 HLA-DRB1 IL2RA PTPN22
20 b-cell expansion with nfkb and t-cell anergy 9.8 IL2RA IL2RB
21 graves' disease 9.7 HLA-DRB1 IL2RA PTPN22
22 diabetes mellitus, insulin-dependent 9.6 HLA-DRB1 IL2RA PTPN22
23 sezary's disease 9.5 IL2RA STAT4
24 inflammatory bowel disease 9.5 HLA-DRB1 PTPN22 SLC11A1 STAT4
25 alopecia areata 9.4 IL2RA PTPN22
26 autoimmune disease 9.2 HLA-DRB1 IL2RA PTPN22 STAT4
27 systemic lupus erythematosus 9.1 HLA-DRB1 IL2RA PTPN22 STAT4
28 rheumatoid arthritis 8.8 HLA-DRB1 IL2RA PTPN22 SLC11A1 STAT4
29 oligoarticular juvenile idiopathic arthritis 6.6 ANKRD55 CD247 HLA-DRB1 IL2RA IL2RB PTPN2

Graphical network of the top 20 diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:



Diseases related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Symptoms & Phenotypes for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Human phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

59 32 (show all 11)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 joint dislocation 59 32 hallmark (90%) Very frequent (99-80%) HP:0001373
2 dental malocclusion 59 32 hallmark (90%) Very frequent (99-80%) HP:0000689
3 joint swelling 59 32 hallmark (90%) Very frequent (99-80%) HP:0001386
4 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
5 limitation of joint mobility 59 32 hallmark (90%) Very frequent (99-80%) HP:0001376
6 apraxia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002186
7 elevated c-reactive protein level 59 32 hallmark (90%) Very frequent (99-80%) HP:0011227
8 elevated erythrocyte sedimentation rate 59 32 hallmark (90%) Very frequent (99-80%) HP:0003565
9 antinuclear antibody positivity 59 32 hallmark (90%) Very frequent (99-80%) HP:0003493
10 polyarticular arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0005764
11 juvenile rheumatoid arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0005681

MGI Mouse Phenotypes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.63 CD247 IL2RA IL2RB PTPN2 PTPN22 STAT4
2 hematopoietic system MP:0005397 9.5 SLC11A1 STAT4 CD247 IL2RA IL2RB PTPN2
3 immune system MP:0005387 9.17 CD247 IL2RA IL2RB PTPN2 PTPN22 SLC11A1

Drugs & Therapeutics for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search Clinical Trials , NIH Clinical Center for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Genetic Tests for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Anatomical Context for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

MalaCards organs/tissues related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

41
Bone, Eye

Publications for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Articles related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis:

# Title Authors Year
1
Predictors of Flare Following Etanercept Withdrawal in Patients with Rheumatoid Factor-negative Juvenile Idiopathic Arthritis Who Reached Remission while Taking Medication. ( 29717035 )
2018
2
Association of SLC11A1 (NRAMP1) with persistent oligoarticular and polyarticular rheumatoid factor-negative juvenile idiopathic arthritis in Finnish patients: haplotype analysis in Finnish families. ( 15641099 )
2005

Variations for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Expression for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Search GEO for disease gene expression data for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis.

Pathways for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Pathways related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CD247 HLA-DRB1 IL2RA IL2RB PTPN2 PTPN22
2
Show member pathways
12.37 IL2RA IL2RB PTPN2 STAT4
3 12.28 IL2RA IL2RB PTPN2 PTPN22 STAT4
4 12.15 HLA-DRB1 IL2RA IL2RB
5
Show member pathways
12.14 CD247 HLA-DRB1 IL2RA IL2RB STAT4
6
Show member pathways
12.11 CD247 HLA-DRB1 IL2RA IL2RB
7
Show member pathways
12.06 CD247 HLA-DRB1 PTPN22
8
Show member pathways
11.79 CD247 HLA-DRB1 IL2RA IL2RB STAT4
9
Show member pathways
11.71 CD247 HLA-DRB1 PTPN22
10 11.63 IL2RA IL2RB STAT4
11 11.48 CD247 HLA-DRB1 PTPN22
12
Show member pathways
11.42 IL2RA IL2RB
13
Show member pathways
11.41 CD247 HLA-DRB1 IL2RA IL2RB STAT4
14
Show member pathways
11.34 CD247 IL2RA IL2RB STAT4
15 11.26 IL2RA STAT4
16 11.24 IL2RA IL2RB STAT4
17 11.18 PTPN2 STAT4
18 11.07 IL2RA IL2RB
19
Show member pathways
10.99 IL2RA STAT4
20 10.37 CD247 HLA-DRB1 IL2RA STAT4

GO Terms for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

Cellular components related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 HLA-DRB1 IL2RA IL2RB

Biological processes related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 CD247 HLA-DRB1 IL2RA PTPN22
2 cytokine-mediated signaling pathway GO:0019221 9.63 IL2RA IL2RB STAT4
3 T cell receptor signaling pathway GO:0050852 9.5 CD247 HLA-DRB1 PTPN22
4 negative regulation of T cell proliferation GO:0042130 9.43 HLA-DRB1 IL2RA
5 T cell differentiation GO:0030217 9.4 PTPN2 PTPN22
6 negative regulation of T cell receptor signaling pathway GO:0050860 9.26 PTPN2 PTPN22
7 inflammatory response to antigenic stimulus GO:0002437 9.16 HLA-DRB1 IL2RA
8 interleukin-2-mediated signaling pathway GO:0038110 8.96 IL2RA IL2RB
9 interleukin-2 production GO:0032623 8.62 CD247 SLC11A1

Molecular functions related to Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase binding GO:1990782 9.16 CD247 PTPN22
2 interleukin-2 binding GO:0019976 8.96 IL2RA IL2RB
3 interleukin-2 receptor activity GO:0004911 8.62 IL2RA IL2RB

Sources for Rheumatoid Factor-Negative Juvenile Idiopathic Arthritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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