MCID: RHM009
MIFTS: 37

Rheumatoid Lung Disease

Categories: Bone diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Rheumatoid Lung Disease

Summaries for Rheumatoid Lung Disease

MalaCards based summary : Rheumatoid Lung Disease, also known as rheumatoid lung, is related to lung disease and pulmonary fibrosis, idiopathic. An important gene associated with Rheumatoid Lung Disease is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. Affiliated tissues include lung, bone and skin.

Wikipedia : 76 Rheumatoid Lung Disease, also called Rheumatoid Lung is a disease of the lung associated with RA,... more...

Related Diseases for Rheumatoid Lung Disease

Diseases related to Rheumatoid Lung Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 lung disease 30.6 IL17A IL1B TNF
2 pulmonary fibrosis, idiopathic 29.6 IL1B MUC1 TNF
3 interstitial lung disease 29.4 IL1B MUC1 TNF
4 arthritis 29.3 IL17A IL1B MMP3 TNF TNFRSF1B
5 rheumatoid arthritis 29.0 IL17A IL1B MMP3 TNF TNFRSF1B
6 cardiac sarcoidosis 10.2 SMUG1 TNF
7 tuberculous peritonitis 10.2 SMUG1 TNF
8 rectum squamous cell carcinoma 10.2 SMUG1 TNFRSF1B
9 chondromalacia 10.2 SMUG1 TNFRSF1B
10 granulomatous myositis 10.2 SMUG1 TNFRSF1B
11 skin sarcoidosis 10.2 TNF TNFRSF1B
12 juvenile ankylosing spondylitis 10.2 TNF TNFRSF1B
13 chronic gonococcal salpingitis 10.2 TNF TNFRSF1B
14 granulomatous dermatitis 10.2 TNF TNFRSF1B
15 scleral disease 10.2 TNF TNFRSF1B
16 pustulosis of palm and sole 10.2 TNF TNFRSF1B
17 peroneal neuropathy 10.2 TNF TNFRSF1B
18 pneumocystosis 10.2 MUC1 TNF
19 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
20 acute salpingitis 10.2 TNF TNFRSF1B
21 lymphangiosarcoma 10.2 SMUG1 TNF
22 chronic orbital inflammation 10.2 MUC1 TNFRSF1B
23 trichosporonosis 10.1 IL17A TNF
24 post-transplant lymphoproliferative disease 10.1 TNF TNFRSF1B
25 chronic salpingitis 10.1 TNF TNFRSF1B
26 pericardial mesothelioma 10.1 MUC1 SMUG1
27 chickenpox 10.1 MUC1 TNFRSF1B
28 ileitis 10.1 IL17A TNF
29 autoimmune disease of eyes, ear, nose and throat 10.1 IL17A TNF
30 transverse myelitis 10.1 IL17A TNF
31 myelitis 10.1 IL17A TNF
32 frozen shoulder 10.1 IL1B MMP3
33 mycoplasma pneumoniae pneumonia 10.1 IL17A TNF
34 filamentary keratitis 10.1 IL17A MUC1
35 fasciitis 10.1 MUC1 TNF
36 exudative glomerulonephritis 10.1 IL1B TNF
37 staphylococcal toxic shock syndrome 10.1 IL1B TNF
38 corneal ulcer 10.1 IL1B MMP3
39 melkersson-rosenthal syndrome 10.1 TNF TNFRSF1B
40 stromal keratitis 10.1 IL17A TNF
41 tracheal cancer 10.1 SMUG1 TNFRSF1B
42 kashin-beck disease 10.1 IL1B TNF
43 vulvar vestibulitis syndrome 10.1 IL1B TNF
44 burns 10.1 IL1B TNF
45 hidradenitis suppurativa 10.1 IL17A TNF
46 glossitis 10.1 IL1B TNF
47 hidradenitis 10.1 IL17A TNF
48 laryngitis 10.1 IL1B TNF
49 haemophilus influenzae 10.1 IL1B TNF
50 opisthorchiasis 10.1 IL1B TNF

Comorbidity relations with Rheumatoid Lung Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Bronchitis
Deficiency Anemia Heart Disease
Idiopathic Interstitial Pneumonia Osteoporosis
Postinflammatory Pulmonary Fibrosis Respiratory Failure
Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Rheumatoid Lung Disease:



Diseases related to Rheumatoid Lung Disease

Symptoms & Phenotypes for Rheumatoid Lung Disease

Drugs & Therapeutics for Rheumatoid Lung Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Active Rheumatoid Arthritis Terminated NCT01261403 Phase 2 Vehicle Controlled Placebo
2 Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis Unknown status NCT01641705
3 Creation of a Biospecimen Repository From Patients With Interstitial Lung Diseases (ILD) Recruiting NCT03478826

Search NIH Clinical Center for Rheumatoid Lung Disease

Genetic Tests for Rheumatoid Lung Disease

Anatomical Context for Rheumatoid Lung Disease

MalaCards organs/tissues related to Rheumatoid Lung Disease:

41
Lung, Bone, Skin, Lymph Node, Eye, Spinal Cord, Prostate

Publications for Rheumatoid Lung Disease

Articles related to Rheumatoid Lung Disease:

(show top 50) (show all 60)
# Title Authors Year
1
Rheumatoid lung nodulosis during anti-TNF therapy. ( 28038860 )
2017
2
NLRP3 inflammasome expression in idiopathic pulmonary fibrosis and rheumatoid lung. ( 26743485 )
2016
3
Rheumatoid lung. ( 25956496 )
2015
4
Rheumatoid lung nodule. ( 26516255 )
2015
5
Diagnostic performances of high resolution trans-thoracic lung ultrasonography in pulmonary alveoli-interstitial involvement of rheumatoid lung disease. ( 23936595 )
2013
6
Role of (18)F-FDG PET Scan in Rheumatoid Lung Nodule: Case Report and Review of the Literature. ( 23984160 )
2013
7
Rheumatoid lung disease: prognostic analysis of 54 biopsy-proven cases. ( 22560113 )
2012
8
Massive spontaneous hemopneumothorax complicating rheumatoid lung disease. ( 17383372 )
2007
9
Rheumatoid lung disease as seen on PET/CT scan. ( 17710040 )
2007
10
Rheumatoid lung disease. ( 17684286 )
2007
11
Multiple calcified pulmonary nodules: an unusual presentation of rheumatoid lung. ( 17293222 )
2007
12
Rheumatoid lung nodulosis and osteopathy associated with leflunomide therapy. ( 16211338 )
2006
13
Acute progression of interstitial lung disease: a complication of etanercept particularly in the presence of rheumatoid lung and methotrexate treatment. ( 16760195 )
2006
14
Role of KL-6 in evaluating the disease severity of rheumatoid lung disease: comparison with HRCT. ( 15526815 )
2004
15
Methotrexate and the rheumatoid lung: a riddle wrapped in an enigma. ( 14593492 )
2004
16
Rheumatoid lung nodules with hydropneumothorax. ( 14563474 )
2003
17
Gold-induced pulmonary disease: clinical features, outcome, and differentiation from rheumatoid lung disease. ( 9116980 )
1997
18
Rheumatoid arthritis: classical rheumatoid lung disease. ( 8519069 )
1993
19
Cellular basis for elevated gallium-67 uptake in rheumatoid lung patient. ( 8429361 )
1993
20
Rheumatoid arthritis: other rheumatoid lung problems. ( 8519073 )
1993
21
Bronchoalveolar lavage in patients with mild and severe rheumatoid lung disease. ( 2169654 )
1990
22
Spontaneous pneumothorax complicating rheumatoid lung disease. ( 2638671 )
1989
23
Unilateral recurrent pneumothorax complicating rheumatoid lung. ( 2600437 )
1989
24
Rheumatoid arthritis presenting as arthritis mutilans with rheumatoid lung. ( 3379317 )
1988
25
Rheumatoid lung cavitation and response to penicillamine. ( 3501905 )
1987
26
CT appearances of rheumatoid lung disease. ( 6470256 )
1984
27
Bilateral pneumothoraces and pleural effusions in rheumatoid lung disease. ( 6710432 )
1984
28
Bilateral pneumothoraces and pleural effusions complicating rheumatoid lung disease. ( 6857576 )
1983
29
Rheumatoid lung disease, pneumothorax, and eosinophilia. ( 7073341 )
1982
30
Broncho-pleural fistula complicating rheumatoid lung disease. ( 7100049 )
1982
31
Rheumatoid lung disease. (A clinical, physiological and histological study in 33 patients). ( 7209294 )
1980
32
The case of the rheumatoid lung. ( 7399469 )
1980
33
Carcinoma of the colon presenting as rheumatoid lung. ( 7426290 )
1980
34
Bronchiolitis obliterans. A new form of rheumatoid lung? ( 620595 )
1978
35
Roentgenogram of the month. Productive cough and hemoptysis in rheumatoid lung disease. ( 1269277 )
1976
36
Cavitary pulmonary lymphosarcoma masquerading as rheumatoid lung disease. ( 1083917 )
1976
37
Rheumatoid lung disease; granulomas, fibrosis, pulmonary effusion. ( 1055882 )
1975
38
Rheumatoid lung. ( 1205548 )
1975
39
Rheumatoid lung disease with pulmonary fibrosis necrobiotic nodules and pleural effusion. ( 4715613 )
1973
40
Scar cancer of lung complicating rheumatoid lung disease. ( 4357248 )
1973
41
Interstitial rheumatoid lung disease. A reassessment and review of the literature. ( 5066501 )
1972
42
Immunofluorescent and immunologic studies of rheumatoid lung. ( 4111725 )
1972
43
Empyema in rheumatoid lung disease. ( 5315083 )
1971
44
Cytoplasmic lamellar inclusions resembling tissue mast cel granules in suspected rheumatoid lung disease. ( 5347074 )
1969
45
Rheumatoid lung disease. ( 6037347 )
1967
46
Pyopneumothorax in rheumatoid lung disease. ( 5914995 )
1966
47
Rheumatoid lung disease with report of a case. ( 5924576 )
1966
48
Cholesterol pleural effusion in rheumatoid lung disease. ( 5972525 )
1966
49
Rheumatoid lung disease with cavitary nodules, pneumothorax and eosinophilia. ( 5918107 )
1966
50
The five manifestations of rheumatoid lung. ( 5907805 )
1966

Variations for Rheumatoid Lung Disease

Expression for Rheumatoid Lung Disease

Search GEO for disease gene expression data for Rheumatoid Lung Disease.

Pathways for Rheumatoid Lung Disease

Pathways related to Rheumatoid Lung Disease according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 IL17A IL1B MMP3 MUC1 TNF TNFRSF1B
2
Show member pathways
12.62 IL17A IL1B TNF TNFRSF1B
3 12.31 IL17A IL1B TNF TNFRSF1B
4
Show member pathways
12.2 IL17A IL1B TNF
5
Show member pathways
12.04 IL17A IL1B MMP3 TNF
6
Show member pathways
11.94 IL1B MUC1 TNF
7
Show member pathways
11.81 IL17A IL1B TNF
8
Show member pathways
11.79 IL1B MMP3 TNF
9 11.6 IL1B MMP3 TNF TNFRSF1B
10 11.56 IL17A IL1B TNF
11
Show member pathways
11.43 IL1B MMP3 TNF
12 11.41 IL17A IL1B MMP3 TNF
13 11.29 IL1B TNF
14
Show member pathways
11.26 IL1B TNF
15 11.23 IL1B TNF TNFRSF1B
16 11.21 MMP3 MUC1
17 11.16 IL1B TNF
18 11.16 IL17A IL1B MMP3 MUC1 TNF TNFRSF1B
19 11.15 IL1B TNF
20 11.11 IL17A IL1B MMP3 TNF
21 11.1 TNF TNFRSF1B
22 11.08 IL1B TNF
23 11.05 IL1B TNF
24 11 IL17A IL1B TNF
25 10.97 IL17A IL1B TNF
26 10.9 IL1B TNF
27 10.74 IL1B TNF

GO Terms for Rheumatoid Lung Disease

Cellular components related to Rheumatoid Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 IL17A IL1B MMP3 MUC1 TNF TNFRSF1B

Biological processes related to Rheumatoid Lung Disease according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 IL17A IL1B TNF TNFRSF1B
2 inflammatory response GO:0006954 9.78 IL17A IL1B TNF TNFRSF1B
3 cellular response to lipopolysaccharide GO:0071222 9.73 IL1B TNF TNFRSF1B
4 extrinsic apoptotic signaling pathway GO:0097191 9.64 TNF TNFRSF1B
5 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 IL1B TNF
7 positive regulation of JUN kinase activity GO:0043507 9.62 IL1B TNF
8 positive regulation of phagocytosis GO:0050766 9.62 IL1B TNF
9 protein kinase B signaling GO:0043491 9.61 IL1B TNF
10 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.61 IL1B TNF
11 lipopolysaccharide-mediated signaling pathway GO:0031663 9.6 IL1B TNF
12 positive regulation of interleukin-8 production GO:0032757 9.59 IL1B TNF
13 negative regulation of neurogenesis GO:0050768 9.58 IL1B TNF
14 positive regulation of interleukin-6 secretion GO:2000778 9.58 IL17A IL1B
15 positive regulation of osteoclast differentiation GO:0045672 9.57 IL17A TNF
16 negative regulation of lipid catabolic process GO:0050995 9.54 IL1B TNF
17 positive regulation of glial cell proliferation GO:0060252 9.52 IL1B TNF
18 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.51 IL1B TNF
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.49 IL1B TNF
20 positive regulation of chemokine biosynthetic process GO:0045080 9.46 IL1B TNF
21 regulation of establishment of endothelial barrier GO:1903140 9.43 IL1B TNF
22 positive regulation of neuroinflammatory response GO:0150078 9.4 IL1B TNF
23 positive regulation of fever generation GO:0031622 9.37 IL1B TNF
24 chronic inflammatory response to antigenic stimulus GO:0002439 9.32 IL1B TNF
25 sequestering of triglyceride GO:0030730 9.26 IL1B TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B TNF
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.13 IL1B TNF TNFRSF1B
28 cytokine-mediated signaling pathway GO:0019221 9.1 IL17A IL1B MMP3 MUC1 TNF TNFRSF1B

Molecular functions related to Rheumatoid Lung Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IL17A IL1B TNF

Sources for Rheumatoid Lung Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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