MCID: RHM013
MIFTS: 29

Rheumatoid Nodulosis

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Rheumatoid Nodulosis

MalaCards integrated aliases for Rheumatoid Nodulosis:

Name: Rheumatoid Nodulosis 57 20

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
rheumatoid nodulosis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 180350
MedGen 41 C0035450
SNOMED-CT via HPO 68 263681008 95325000

Summaries for Rheumatoid Nodulosis

MalaCards based summary : Rheumatoid Nodulosis is related to synovitis and palindromic rheumatism. An important gene associated with Rheumatoid Nodulosis is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Endometrial cancer and Collagen chain trimerization. Affiliated tissues include skin, spleen and liver, and related phenotype is subcutaneous nodule.

Wikipedia : 73 Rheumatoid nodulosis is a cutaneous condition associated with rheumatoid arthritis, characterized by the... more...

More information from OMIM: 180350

Related Diseases for Rheumatoid Nodulosis

Diseases related to Rheumatoid Nodulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 synovitis 29.9 MMP9 MMP3
2 palindromic rheumatism 10.4
3 enthesopathy 10.4
4 gout 10.3
5 xanthomatosis 10.1
6 plica syndrome 10.1
7 kala-azar 1 10.0
8 hepatitis c virus 10.0
9 hepatitis c 10.0
10 peripheral nervous system disease 10.0
11 vasculitis 10.0
12 neuropathy 10.0
13 leishmaniasis 10.0
14 visceral leishmaniasis 10.0
15 prolapse of lacrimal gland 9.9 MMP9 MMP3
16 spastic entropion 9.9 MMP9 MMP3
17 coronary aneurysm 9.9 MMP9 MMP3
18 perforated corneal ulcer 9.9 MMP9 MMP3
19 corneal ulcer 9.9 MMP9 MMP3
20 heart aneurysm 9.9 MMP9 MMP3
21 conjunctivochalasis 9.9 MMP9 MMP3
22 status asthmaticus 9.8 MMP9 MMP3
23 gingival hypertrophy 9.8 MMP9 MMP3
24 rosacea 9.8 MMP9 MMP3
25 oral submucous fibrosis 9.8 MMP9 MMP3
26 pelvic organ prolapse 9.8 MMP9 MMP3
27 preterm premature rupture of the membranes 9.8 MMP9 MMP3
28 actinic keratosis 9.8 MMP9 MMP3
29 carotid artery disease 9.8 MMP9 MMP3
30 varicose veins 9.8 MMP9 MMP3
31 takayasu arteritis 9.8 MMP9 MMP3
32 arteriovenous malformation 9.8 MMP9 MMP3
33 kawasaki disease 9.8 MMP9 MMP3
34 hyper ige syndrome 9.8 MMP9 MMP3
35 periodontitis 9.8 MMP9 MMP3
36 refractive error 9.8 MMP9 MMP3
37 aortic aneurysm, familial abdominal, 1 9.8 MMP9 MMP3
38 bone inflammation disease 9.8 MMP9 MMP3
39 pseudoxanthoma elasticum 9.8 MMP9 MMP3
40 endometrial stromal sarcoma 9.8 MMP9 MMP3
41 keratoconus 9.8 MMP9 MMP3
42 osteoarthritis 9.8 MMP9 MMP3
43 pancreatic adenocarcinoma 9.8 MMP9 MMP3
44 fibrosarcoma 9.7 MMP9 MMP3
45 tetralogy of fallot 9.7 MMP9 MMP3
46 basal cell carcinoma 9.7 MMP9 MMP3
47 scoliosis 9.7 MMP9 MMP3
48 vascular disease 9.7 MMP9 MMP3
49 nasopharyngeal carcinoma 9.6 MMP9 MMP3
50 chronic kidney disease 9.6 MMP9 MMP3

Graphical network of the top 20 diseases related to Rheumatoid Nodulosis:



Diseases related to Rheumatoid Nodulosis

Symptoms & Phenotypes for Rheumatoid Nodulosis

Human phenotypes related to Rheumatoid Nodulosis:

31
# Description HPO Frequency HPO Source Accession
1 subcutaneous nodule 31 HP:0001482

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Limbs:
longstanding, multiple, subcutaneous nodules

Lab:
histopathology characteristic of rheumatoid nodules
no serologic evidence of rheumatic disease
no abnormality of leukocyte function

Joints:
no clinical evidence of rheumatoid arthritis

Clinical features from OMIM®:

180350 (Updated 05-Apr-2021)

Drugs & Therapeutics for Rheumatoid Nodulosis

Search Clinical Trials , NIH Clinical Center for Rheumatoid Nodulosis

Genetic Tests for Rheumatoid Nodulosis

Anatomical Context for Rheumatoid Nodulosis

MalaCards organs/tissues related to Rheumatoid Nodulosis:

40
Skin, Spleen, Liver, Pancreas, Monocytes

Publications for Rheumatoid Nodulosis

Articles related to Rheumatoid Nodulosis:

(show top 50) (show all 67)
# Title Authors PMID Year
1
Rheumatoid nodulosis. Sporadic and familial diseases. 57 61
490522 1979
2
Granulomatous Cutaneous Drug Eruptions: A Systematic Review. 61
33108647 2021
3
Methotrexate-Induced Acute Rheumatoid Nodulosis in Liver and Spleen Imitating Metastatic Malignancy. 61
32826660 2020
4
Rheumatoid Nodulosis in an Adult Patient Negative for Rheumatoid Factor. 61
31196557 2019
5
Bilateral epibulbar pseudorheumatoid nodulosis with a review of ocular adnexal palisading granulomas. 61
30772365 2019
6
Skin manifestations of rheumatoid arthritis. 61
29368864 2018
7
Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides. 61
28752373 2017
8
18F-FDG PET/CT of extensive rheumatoid nodulosis. 61
28890997 2017
9
Rheumatoid nodulosis with extra-articular cyst synovitis. 61
26284464 2015
10
Benign rheumatoid nodulosis. 61
25776448 2015
11
Occurrence of pulmonary rheumatoid nodules following biological therapies. 61
25267563 2015
12
Granulomatous Drug Eruptions. 61
26143430 2015
13
Azathioprine-induced accelerated cutaneous and pulmonary nodulosis in a patient with rheumatoid arthritis. 61
26312704 2015
14
Epstein-Barr virus-associated methotrexate-induced accelerated rheumatoid nodulosis. 61
24710629 2015
15
Spacing of toes reveals rheumatoid nodulosis. 61
24788465 2014
16
Soft tissue swellings in the foot: rheumatoid nodulosis. 61
24534374 2014
17
Seronegative rheumatoid nodulosis: a new case report. 61
22580325 2012
18
A Seropositive Nodular Rheumatoid Polyarthritis without Arthritis: Does It Exist? 61
22570663 2012
19
Unusual draining nodules in a patient with rheumatoid nodulosis and hepatitis C virus infection. 61
21807805 2011
20
Accelerated rheumatoid nodulosis mimicking cystic subcutaneous infection. 61
21961896 2011
21
[Leishmaniasis and rheumatoid nodulosis in a patient with HIV infection]. 61
20223159 2010
22
Non-infectious granulomatous diseases of the skin and their associated systemic diseases: an evidence-based update to important clinical questions. 61
20184390 2010
23
Rheumatoid nodulosis: successful response to topical tacrolimus. 61
19653057 2009
24
A 51-year-old man with nodular lesions. Rheumatoid nodulosis. 61
18788224 2008
25
2756GG genotype of methionine synthase reductase gene is more prevalent in rheumatoid arthritis patients treated with methotrexate and is associated with methotrexate-induced nodulosis. 61
17611986 2007
26
Rheumatoid nodule. 61
17544962 2007
27
Juvenile rheumatoid arthritis and bronchiolitis obliterans organized pneumonia. 61
16362444 2007
28
[Bilateral epibulbar rheumatoid nodulosis: case report]. 61
16936975 2006
29
Rheumatoid nodulosis. Two cases with destructive polyarthritis after 20 years. 61
16377229 2006
30
Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis. 61
17165004 2006
31
Rheumatoid arthritis: a review of the cutaneous manifestations. 61
16021111 2005
32
Tumefactive necrobiotic granulomas (nodulosis) of the pancreas in an adult with long-standing rheumatoid arthritis. 61
15864386 2005
33
A case of rheumatoid nodulosis successfully treated with surgery. 61
15729864 2004
34
Rheumatoid nodulosis: report of two cases. 61
14761141 2003
35
Rheumatoid nodulosis: is it a different subset of rheumatoid arthritis? 61
17041479 2003
36
Rheumatoid nodulosis: a diagnostic dilemma. 61
17041477 2003
37
Rheumatoid nodulosis: a new case report. 61
12537272 2002
38
Aspiration cytology of rheumatoid nodulosis: diagnostic method of choice. 61
12462107 2002
39
The HLA-DRB1*0401 allele and the development of methotrexate-induced accelerated rheumatoid nodulosis: a follow-up study of 79 Caucasian patients with rheumatoid arthritis. 61
11470988 2001
40
Accelerated cutaneous nodulosis during methotrexate therapy in a patient with rheumatoid arthritis. 61
9703153 1998
41
HLA DRB1* alleles in rheumatoid nodulosis: a comparative study with rheumatoid arthritis with and without nodules. 61
9592863 1998
42
Inhibition of methotrexate-induced rheumatoid nodulosis by colchicine: evidence from an in vitro model and regression in 7 of 14 patients. 61
19078220 1997
43
Adenosine A1 receptor promotion of multinucleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. 61
9214432 1997
44
Palmar rheumatoid nodulosis of the fingers. 61
8549106 1995
45
Rheumatoid nodulosis of the meninges. 61
7837168 1994
46
Development of persistent destructive arthritis in a patient with rheumatoid nodulosis in spite of an improvement in extra-articular symptoms. 61
8403597 1993
47
[Rheumatoid nodulosis]. 61
8495925 1993
48
[Familial form of rheumatoid nodulosis]. 61
8257029 1993
49
Rheumatoid nodulosis: a puzzling variant of rheumatoid arthritis. 61
1458790 1992
50
Palmar rheumatoid nodulosis associated with local pressure. 61
1417106 1992

Variations for Rheumatoid Nodulosis

Expression for Rheumatoid Nodulosis

Search GEO for disease gene expression data for Rheumatoid Nodulosis.

Pathways for Rheumatoid Nodulosis

Pathways related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 MMP9 MMP3
2
Show member pathways
12.24 MMP9 MMP3
3
Show member pathways
12.15 MMP9 MMP3
4
Show member pathways
11.81 MMP9 MMP3
5 11.74 MMP9 MMP3
6 11.52 MMP9 MMP3
7 11.46 MMP9 MMP3
8 11.42 MMP9 MMP3
9
Show member pathways
11.32 MMP9 MMP3
10 11.21 MMP9 MMP3
11
Show member pathways
10.96 MMP9 MMP3
12 10.74 MMP9 MMP3
13 10.21 MMP9 MMP3

GO Terms for Rheumatoid Nodulosis

Cellular components related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.62 MMP9 MMP3

Biological processes related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.4 MMP9 MMP3
2 extracellular matrix organization GO:0030198 9.37 MMP9 MMP3
3 extracellular matrix disassembly GO:0022617 9.32 MMP9 MMP3
4 collagen catabolic process GO:0030574 9.26 MMP9 MMP3
5 response to amyloid-beta GO:1904645 9.16 MMP9 MMP3
6 regulation of neuroinflammatory response GO:0150077 8.96 MMP9 MMP3
7 cellular response to UV-A GO:0071492 8.62 MMP9 MMP3

Molecular functions related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.32 MMP9 MMP3
2 serine-type endopeptidase activity GO:0004252 9.26 MMP9 MMP3
3 metallopeptidase activity GO:0008237 9.16 MMP9 MMP3
4 metalloendopeptidase activity GO:0004222 8.96 MMP9 MMP3
5 endopeptidase activity GO:0004175 8.62 MMP9 MMP3

Sources for Rheumatoid Nodulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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