MCID: RHM013
MIFTS: 34

Rheumatoid Nodulosis

Categories: Rare diseases, Bone diseases

Aliases & Classifications for Rheumatoid Nodulosis

MalaCards integrated aliases for Rheumatoid Nodulosis:

Name: Rheumatoid Nodulosis 57 53

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
rheumatoid nodulosis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 180350
MedGen 42 C0035450
SNOMED-CT via HPO 69 263681008 95325000

Summaries for Rheumatoid Nodulosis

MalaCards based summary : Rheumatoid Nodulosis is related to arthritis and rheumatoid arthritis. An important gene associated with Rheumatoid Nodulosis is MMP3 (Matrix Metallopeptidase 3), and among its related pathways/superpathways are Endometrial cancer and Collagen chain trimerization. The drugs Leflunomide and rituximab have been mentioned in the context of this disorder. Related phenotype is subcutaneous nodule.

Wikipedia : 76 Rheumatoid nodulosis (also known as \"Accelerated rheumatoid nodulosis\") is a cutaneous condition... more...

Description from OMIM: 180350

Related Diseases for Rheumatoid Nodulosis

Graphical network of the top 20 diseases related to Rheumatoid Nodulosis:



Diseases related to Rheumatoid Nodulosis

Symptoms & Phenotypes for Rheumatoid Nodulosis

Symptoms via clinical synopsis from OMIM:

57
Limbs:
longstanding, multiple, subcutaneous nodules

Lab:
histopathology characteristic of rheumatoid nodules
no serologic evidence of rheumatic disease
no abnormality of leukocyte function

Joints:
no clinical evidence of rheumatoid arthritis


Clinical features from OMIM:

180350

Human phenotypes related to Rheumatoid Nodulosis:

32
# Description HPO Frequency HPO Source Accession
1 subcutaneous nodule 32 HP:0001482

Drugs & Therapeutics for Rheumatoid Nodulosis

Drugs for Rheumatoid Nodulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leflunomide Approved, Investigational Phase 3 75706-12-6 3899
2
rituximab Approved Phase 3 174722-31-7 10201696
3
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
4 Antirheumatic Agents Phase 3
5 Immunosuppressive Agents Phase 3
6 Citrate Nutraceutical Phase 3
7
Etanercept Approved, Investigational 185243-69-0
8
Methotrexate Approved 1959-05-2, 59-05-2 126941
9
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
10
leucovorin Approved, Nutraceutical 58-05-9 143 6006
11 Analgesics
12 Analgesics, Non-Narcotic
13 Anti-Inflammatory Agents
14 Anti-Inflammatory Agents, Non-Steroidal
15 Antimetabolites
16 Antimetabolites, Antineoplastic
17 Dermatologic Agents
18 Folic Acid Antagonists
19 Gastrointestinal Agents
20 Nucleic Acid Synthesis Inhibitors
21 Peripheral Nervous System Agents
22 Vitamin B Complex
23 Folate Nutraceutical
24 Vitamin B9 Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Addition of Rituximab to Leflunomide in Patients With Active Rheumatoid Arthritis Completed NCT01244958 Phase 3 Placebo
2 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Active Rheumatoid Arthritis Terminated NCT01261403 Phase 2 Vehicle Controlled Placebo
3 Characterize Patients With Moderately Active Rheumatoid Arthritis (RA) Completed NCT01557322 methotrexate (MTX)
4 A Non-Interventional Study of RoActemra/Actemra in Patients With Moderate to Severe Rheumatoid Arthritis Completed NCT01672970
5 Observational Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Completed NCT01579006 Tocilizumab
6 A Non-interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Completed NCT01562327 Tocilizumab
7 A Non-Interventional Study in Patients With Moderate to Severe Rheumatoid Arthritis Treated With RoActemra/Actemra (Tocilizumab) Completed NCT01663506
8 An Observational Study in Clinical Practice Management of Patients With Biological Drugs in Monotherapy Completed NCT01664117
9 Cellular & Biocellular Regenerative Therapy in Musculoskeletal Pain, Dysfunction,Degenerative or Inflammatory Disease Recruiting NCT03090672 Not Applicable Normal Saline

Search NIH Clinical Center for Rheumatoid Nodulosis

Genetic Tests for Rheumatoid Nodulosis

Anatomical Context for Rheumatoid Nodulosis

Publications for Rheumatoid Nodulosis

Articles related to Rheumatoid Nodulosis:

(show all 43)
# Title Authors Year
1
(18)F-FDG PET/CT of extensive rheumatoid nodulosis. ( 28890997 )
2017
2
Rheumatoid nodulosis with extra-articular cyst synovitis. ( 26284464 )
2015
3
Benign rheumatoid nodulosis. ( 25776448 )
2015
4
Epstein-Barr Virus-associated Methotrexate-induced Accelerated Rheumatoid Nodulosis. ( 24710629 )
2014
5
Soft tissue swellings in the foot: rheumatoid nodulosis. ( 24534374 )
2014
6
Spacing of toes reveals rheumatoid nodulosis. ( 24788465 )
2014
7
Seronegative rheumatoid nodulosis: a new case report. ( 22580325 )
2012
8
Accelerated rheumatoid nodulosis mimicking cystic subcutaneous infection. ( 21961896 )
2011
9
Unusual draining nodules in a patient with rheumatoid nodulosis and hepatitis C virus infection. ( 21807805 )
2011
10
[Leishmaniasis and rheumatoid nodulosis in a patient with HIV infection]. ( 20223159 )
2010
11
Rheumatoid nodulosis: successful response to topical tacrolimus. ( 19653057 )
2009
12
A 51-year-old man with nodular lesions. Rheumatoid nodulosis. ( 18788224 )
2008
13
Rheumatoid nodulosis. Two cases with destructive polyarthritis after 20 years. ( 16377229 )
2006
14
Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis. ( 17165004 )
2006
15
A case of rheumatoid nodulosis successfully treated with surgery. ( 15729864 )
2004
16
Rheumatoid nodulosis: is it a different subset of rheumatoid arthritis? ( 17041479 )
2003
17
Rheumatoid nodulosis: report of two cases. ( 14761141 )
2003
18
Rheumatoid nodulosis: a diagnostic dilemma. ( 17041477 )
2003
19
Aspiration cytology of rheumatoid nodulosis: diagnostic method of choice. ( 12462107 )
2002
20
Rheumatoid nodulosis: a new case report. ( 12537272 )
2002
21
The HLA-DRB1*0401 allele and the development of methotrexate-induced accelerated rheumatoid nodulosis: a follow-up study of 79 Caucasian patients with rheumatoid arthritis. ( 11470988 )
2001
22
HLA DRB1* alleles in rheumatoid nodulosis: a comparative study with rheumatoid arthritis with and without nodules. ( 9592863 )
1998
23
Inhibition of methotrexate-induced rheumatoid nodulosis by colchicine: evidence from an in vitro model and regression in 7 of 14 patients. ( 19078220 )
1997
24
Palmar rheumatoid nodulosis of the fingers. ( 8549106 )
1995
25
Rheumatoid nodulosis of the meninges. ( 7837168 )
1994
26
[Familial form of rheumatoid nodulosis]. ( 8257029 )
1993
27
Development of persistent destructive arthritis in a patient with rheumatoid nodulosis in spite of an improvement in extra-articular symptoms. ( 8403597 )
1993
28
Rheumatoid nodulosis: a puzzling variant of rheumatoid arthritis. ( 1458790 )
1992
29
Palmar rheumatoid nodulosis associated with local pressure. ( 1417106 )
1992
30
Complete reversal of rheumatoid nodulosis. ( 1865421 )
1991
31
Rheumatoid nodulosis: report of two new cases and discussion of diagnostic criteria. ( 3058975 )
1988
32
Bilateral epibulbar rheumatoid nodulosis. A new ocular entity. ( 3211504 )
1988
33
Rheumatoid nodulosis: report of a case with evidence of intraosseous rheumatoid granuloma. ( 3768059 )
1986
34
Coexistence of rheumatoid nodulosis and gout. ( 3772930 )
1986
35
Rheumatoid nodulosis: an immunohistochemical and ultrastructural study. ( 3532272 )
1986
36
Rheumatoid nodulosis in the foot: a variant of rheumatoid disease. ( 6501797 )
1984
37
Rheumatoid nodulosis of the hand. ( 6725901 )
1984
38
Aneurysm of the sinus of valsalva secondary to rheumatoid nodulosis. ( 7259812 )
1981
39
Rheumatoid nodulosis. A relatively benign rheumatoid variant. ( 7224742 )
1981
40
Rheumatoid nodulosis: a continuum of extra-articular rheumatoid disease. ( 515770 )
1979
41
Rheumatoid nodulosis. Sporadic and familial diseases. ( 490522 )
1979
42
Rheumatoid nodulosis: another cuase of juxtarticular nodules. ( 928691 )
1977
43
Rheumatoid nodulosis: an unusual variant of rheumatoid disease. ( 1078777 )
1975

Variations for Rheumatoid Nodulosis

Expression for Rheumatoid Nodulosis

Search GEO for disease gene expression data for Rheumatoid Nodulosis.

Pathways for Rheumatoid Nodulosis

Pathways related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.27 MMP3 MMP9
2
Show member pathways
12.23 MMP3 MMP9
3
Show member pathways
12.15 MMP3 MMP9
4
Show member pathways
11.81 MMP3 MMP9
5 11.73 MMP3 MMP9
6 11.52 MMP3 MMP9
7 11.46 MMP3 MMP9
8 11.4 MMP3 MMP9
9
Show member pathways
11.32 MMP3 MMP9
10 11.21 MMP3 MMP9
11
Show member pathways
10.96 MMP3 MMP9
12 10.74 MMP3 MMP9
13 10.21 MMP3 MMP9

GO Terms for Rheumatoid Nodulosis

Cellular components related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.62 MMP3 MMP9

Biological processes related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.16 MMP3 MMP9
2 extracellular matrix disassembly GO:0022617 8.96 MMP3 MMP9
3 collagen catabolic process GO:0030574 8.62 MMP3 MMP9

Molecular functions related to Rheumatoid Nodulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidase activity GO:0008233 9.32 MMP3 MMP9
2 serine-type endopeptidase activity GO:0004252 9.26 MMP3 MMP9
3 metallopeptidase activity GO:0008237 9.16 MMP3 MMP9
4 metalloendopeptidase activity GO:0004222 8.96 MMP3 MMP9
5 endopeptidase activity GO:0004175 8.62 MMP3 MMP9

Sources for Rheumatoid Nodulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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