MCID: RHM014
MIFTS: 41

Rheumatoid Vasculitis

Categories: Rare diseases, Bone diseases, Cardiovascular diseases

Aliases & Classifications for Rheumatoid Vasculitis

MalaCards integrated aliases for Rheumatoid Vasculitis:

Name: Rheumatoid Vasculitis 53 55 73

Classifications:



External Ids:

ICD10 33 M05.2
UMLS 73 C0240903

Summaries for Rheumatoid Vasculitis

MalaCards based summary : Rheumatoid Vasculitis is related to vasculitis and glomerulonephritis. An important gene associated with Rheumatoid Vasculitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Interferon gamma signaling. Affiliated tissues include skin, liver and endothelial, and related phenotypes are cellular and hematopoietic system

Wikipedia : 76 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

Related Diseases for Rheumatoid Vasculitis

Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.4 CX3CL1 ICAM1 SELE TNF VCAM1
2 glomerulonephritis 29.5 ICAM1 MIF VCAM1
3 rheumatoid arthritis 28.5 HLA-DRB1 ICAM1 MIF SELE TNF VCAM1
4 critical limb ischemia 10.8 SELE TNF
5 scleritis 10.8 SELE TNF
6 heterophyiasis 10.8 ICAM1 SELE
7 retinitis pigmentosa 60 10.7 SELE TNF
8 plummer's disease 10.7 ICAM1 SELE
9 microscopic polyangiitis 10.7 HLA-DRB1 TNF
10 hymenolepiasis 10.7 ICAM1 SELE
11 beryllium disease 10.7 HLA-DRB1 TNF
12 autoimmune pancreatitis 10.7 HLA-DRB1 TNF
13 chronic beryllium disease 10.7 HLA-DRB1 TNF
14 cortical thymoma 10.7 ICAM1 VCAM1
15 anca-associated vasculitis 10.7 HLA-DRB1 TNF
16 endophthalmitis 10.6 ICAM1 SELE
17 sympathetic ophthalmia 10.6 HLA-DRB1 TNF
18 poliomyelitis 10.6 ICAM1 TNF
19 nontuberculous mycobacterial lung disease 10.6 HLA-DRB1 TNF
20 hypersensitivity reaction type iii disease 10.6 ICAM1 SELE
21 immune-complex glomerulonephritis 10.6 ICAM1 VCAM1
22 microscopic colitis 10.6 HLA-DRB1 TNF
23 central nervous system vasculitis 10.6 HLA-DRB1 TNF
24 listeria meningitis 10.6 CX3CL1 TNF
25 pustulosis palmaris et plantaris 10.6 SELE TNF
26 limbal stem cell deficiency 10.6 ICAM1 VCAM1
27 erythema multiforme 10.6 ICAM1 TNF
28 alveolar echinococcosis 10.6 HLA-DRB1 TNF
29 endometritis 10.6 SELE TNF
30 hemorrhagic fever 10.5 HLA-DRB1 TNF
31 henoch-schoenlein purpura 10.5 ICAM1 VCAM1
32 pityriasis rosea 10.5 CX3CL1 HLA-DRB1
33 lichen disease 10.5 ICAM1 TNF
34 localized scleroderma 10.5 SELE TNF
35 panuveitis 10.5 HLA-DRB1 TNF
36 plasmodium vivax malaria 10.4 ICAM1 SELE TNF
37 cutaneous lupus erythematosus 10.4 ICAM1 SELE TNF
38 allergic contact dermatitis 10.4 ICAM1 SELE TNF
39 arteriosclerosis obliterans 10.4 ICAM1 VCAM1
40 contact dermatitis 10.4 ICAM1 SELE TNF
41 warthin tumor 10.4 CD44 VCAM1
42 colon carcinoma in situ 10.4 CD44 ICAM1
43 hydrocele 10.4 CD44 SELE
44 lymphocytic vasculitis 10.4 ICAM1 SELE VCAM1
45 mooren's ulcer 10.4 ICAM1 SELE VCAM1
46 primary progressive multiple sclerosis 10.4 ICAM1 TNF VCAM1
47 subendocardial myocardial infarction 10.4 ICAM1 SELE VCAM1
48 leukostasis 10.4 ICAM1 SELE VCAM1
49 shwartzman phenomenon 10.4 ICAM1 SELE VCAM1
50 trypanosomiasis 10.4 ICAM1 TNF VCAM1

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to Rheumatoid Vasculitis

Symptoms & Phenotypes for Rheumatoid Vasculitis

MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 MIF CD44 SELE CX3CL1 ICAM1 SRF
2 hematopoietic system MP:0005397 10.02 MIF VCAM1 CD44 REN SELE CX3CL1
3 cardiovascular system MP:0005385 10.01 CD44 REN SELE CX3CL1 ICAM1 SRF
4 homeostasis/metabolism MP:0005376 9.96 MIF VCAM1 CD44 REN SELE CX3CL1
5 immune system MP:0005387 9.85 MIF VCAM1 CD44 REN SELE CX3CL1
6 neoplasm MP:0002006 9.35 TNF MIF CD44 ICAM1 LTF
7 normal MP:0002873 9.1 LTF MIF REN CD44 SELE SRF

Drugs & Therapeutics for Rheumatoid Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Non-Interventional Study of RoActemra/Actemra in Patients With Moderate to Severe Rheumatoid Arthritis Completed NCT01672970
2 A Non-interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Completed NCT01562327 Tocilizumab
3 A Non-Interventional Study in Patients With Moderate to Severe Rheumatoid Arthritis Treated With RoActemra/Actemra (Tocilizumab) Completed NCT01663506
4 JOURNEY II XR Safety and Effectiveness PMCF Recruiting NCT03136887

Search NIH Clinical Center for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

Anatomical Context for Rheumatoid Vasculitis

MalaCards organs/tissues related to Rheumatoid Vasculitis:

41
Skin, Liver, Endothelial, Salivary Gland, Neutrophil, Retina, Bone

Publications for Rheumatoid Vasculitis

Articles related to Rheumatoid Vasculitis:

(show top 50) (show all 141)
# Title Authors Year
1
Abatacept as a Therapeutic Option for Rheumatoid Vasculitis. ( 29930884 )
2018
2
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? ( 28293454 )
2017
3
A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. ( 28581281 )
2017
4
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia. ( 28539558 )
2017
5
Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace. ( 28631066 )
2017
6
Recurrent Stenosis of the Ileum Caused by Rheumatoid Vasculitis. ( 27041172 )
2016
7
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. ( 27672862 )
2016
8
Rheumatoid vasculitis: early presentation of rheumatoid arthritis. ( 27873751 )
2016
9
New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab. ( 27052429 )
2016
10
Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. ( 26955985 )
2016
11
Refractory rheumatoid vasculitis-a therapeutic dilemma. ( 28031846 )
2016
12
A case of rheumatoid vasculitis with acquired reactive perforating collagenosis. ( 27846744 )
2016
13
A case of rheumatoid vasculitis. ( 27037329 )
2016
14
Refractory rheumatoid vasculitis. ( 28031844 )
2016
15
New insight into the rheumatoid vasculitis. ( 26402981 )
2015
16
Rheumatoid Vasculitis. ( 26278313 )
2015
17
The dramatic effect of dapsone on cutaneous bullous and pustular rheumatoid vasculitis on the sole. ( 25865233 )
2015
18
Rheumatoid vasculitis - Case report. ( 25772654 )
2015
19
Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna : A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis. ( 26555550 )
2015
20
The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. ( 26106958 )
2015
21
Rheumatoid vasculitis: going, going, but not yet gone. ( 25952359 )
2015
22
Severe gangrene accompanied by varicella zoster virus-related vasculitis mimicking rheumatoid vasculitis. ( 24761143 )
2014
23
Rheumatoid arthritis: Rheumatoid vasculitis--down but not out. ( 24595091 )
2014
24
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. ( 24533557 )
2014
25
Rheumatoid vasculitis: an update. ( 25405822 )
2014
26
Systemic rheumatoid vasculitis in the era of modern immunosuppressive therapy. ( 24108586 )
2014
27
Peripheral ulcerative keratitis as the presenting feature of systemic rheumatoid vasculitis without joint involvement. ( 24234515 )
2013
28
Successful treatment of rheumatoid vasculitis-associated skin ulcer with a TNF-I+ antagonist. ( 23557520 )
2013
29
Successful treatment of digital tip necrosis in rheumatoid vasculitis with anti-CD20 antibody rituximab. ( 23319024 )
2013
30
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. ( 23494445 )
2013
31
The rapid efficacy of abatacept in a patient with rheumatoid vasculitis. ( 22124545 )
2012
32
Foot ulcers caused by rheumatoid vasculitis in a patient with rheumatoid arthritis undergoing etanercept treatment. ( 23154729 )
2012
33
Association of HLA-DRB5*01 with protection against cutaneous manifestations of rheumatoid vasculitis in Brazilian patients. ( 22641591 )
2012
34
Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity. ( 21607712 )
2012
35
Cerebral rheumatoid vasculitis: a case report. ( 22974191 )
2012
36
Successful treatment with humanised anti-interleukin 6 receptor antibody for multidrug-refractory and anti-tumour necrosis factor-resistant systemic rheumatoid vasculitis. ( 21385558 )
2011
37
Case of severe liver damage after the induction of tocilizumab therapy for rheumatoid vasculitis. ( 21435128 )
2011
38
Rheumatoid vasculitis: vanishing menace or target for new treatments? ( 20842467 )
2010
39
Are anti-cyclic citrullinated peptide autoantibodies seromarkers for rheumatoid vasculitis in a cohort of patients with systemic vasculitis? ( 20107034 )
2010
40
Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy: histologic and MRI study. ( 19639318 )
2010
41
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. ( 19714622 )
2009
42
Disseminated herpes zoster mimicking rheumatoid vasculitis in a rheumatoid arthritis patient on etanercept. ( 19648728 )
2009
43
Successful treatment of rheumatoid vasculitis-associated cutaneous ulcers using rituximab in two patients with rheumatoid arthritis. ( 18411212 )
2008
44
Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody. ( 18711097 )
2008
45
Nasal tip necrosis--an unusual presentation of rheumatoid vasculitis. ( 17318275 )
2007
46
A case of rheumatoid vasculitis involving the gastrointestinal tract in early disease. ( 17908700 )
2007
47
Systemic rheumatoid vasculitis: a review. ( 17023257 )
2006
48
Successful treatment of rheumatoid vasculitis-associated foot drop with rituximab. ( 16936329 )
2006
49
Increased serum levels of soluble fractalkine (CX3CL1) correlate with disease activity in rheumatoid vasculitis. ( 17075825 )
2006
50
Should anti-tumor necrosis factor-alpha be the first therapy for rheumatoid vasculitis? ( 16465676 )
2006

Variations for Rheumatoid Vasculitis

Expression for Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for Rheumatoid Vasculitis

Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 CD44 HLA-DRB1 ICAM1 TNF VCAM1
2
Show member pathways
12.3 CD44 HLA-DRB1 ICAM1 VCAM1
3
Show member pathways
12.18 CD44 ICAM1 SELE VCAM1
4 12.17 HLA-DRB1 ICAM1 SRF TNF VCAM1
5 12.09 CD44 HLA-DRB1 ICAM1
6
Show member pathways
12.03 CD44 MIF SELE
7
Show member pathways
11.94 CD44 ICAM1 VCAM1
8 11.92 HLA-DRB1 ICAM1 SELE VCAM1
9 11.88 ICAM1 SELE TNF VCAM1
10 11.84 CD44 ICAM1 VCAM1
11 11.82 ICAM1 MIF TNF
12 11.79 ICAM1 TNF VCAM1
13 11.71 CD44 HLA-DRB1 TNF
14 11.7 ICAM1 SELE TNF VCAM1
15 11.69 ICAM1 TNF VCAM1
16 11.65 HLA-DRB1 ICAM1 TNF
17 11.39 CX3CL1 ICAM1 SELE TNF VCAM1
18 11.31 ICAM1 SELE VCAM1
19 11.25 ICAM1 SELE TNF VCAM1
20 11.08 HLA-DRB1 TNF
21 11 ICAM1 SELE TNF VCAM1
22 10.93 TNF VCAM1
23
Show member pathways
10.82 ICAM1 MIF SELE TNF VCAM1
24 10.7 ICAM1 TNF VCAM1

GO Terms for Rheumatoid Vasculitis

Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CX3CL1 ICAM1 LTF MIF REN SELE
2 external side of plasma membrane GO:0009897 9.46 HLA-DRB1 ICAM1 TNF VCAM1
3 membrane raft GO:0045121 9.43 ICAM1 SELE TNF
4 cell surface GO:0009986 9.23 CD44 CX3CL1 HLA-DRB1 ICAM1 LTF MIF

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.92 CD44 CX3CL1 ICAM1 SELE VCAM1
2 inflammatory response GO:0006954 9.91 CX3CL1 MIF SELE TNF
3 cytokine-mediated signaling pathway GO:0019221 9.87 CX3CL1 ICAM1 TNF VCAM1
4 response to hypoxia GO:0001666 9.8 ICAM1 SRF VCAM1
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 ICAM1 LTF TNF
6 cellular response to tumor necrosis factor GO:0071356 9.79 CX3CL1 ICAM1 VCAM1
7 cell-matrix adhesion GO:0007160 9.75 CD44 SRF VCAM1
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.73 CD44 ICAM1 MIF
9 extracellular matrix organization GO:0030198 9.73 CD44 ICAM1 TNF VCAM1
10 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.71 CD44 MIF TNF
11 response to lipopolysaccharide GO:0032496 9.71 ICAM1 REN SELE VCAM1
12 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.64 CX3CL1 TNF
13 cell aging GO:0007569 9.64 ICAM1 MIF
14 positive regulation of cytokine secretion GO:0050715 9.63 MIF TNF
15 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.63 ICAM1 SELE VCAM1
16 cell-cell adhesion GO:0098609 9.62 CD44 ICAM1 SRF VCAM1
17 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.61 CD44 MIF
18 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.6 CD44 MIF
19 angiogenesis involved in wound healing GO:0060055 9.59 CX3CL1 SRF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.58 CD44 TNF
21 leukocyte migration involved in inflammatory response GO:0002523 9.55 CX3CL1 SELE
22 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.55 CD44 CX3CL1 ICAM1 MIF TNF
23 leukocyte cell-cell adhesion GO:0007159 9.54 ICAM1 SELE VCAM1
24 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.51 ICAM1 TNF
25 membrane to membrane docking GO:0022614 9.49 ICAM1 VCAM1
26 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.48 MIF TNF
27 leukocyte tethering or rolling GO:0050901 9.43 SELE TNF VCAM1
28 interferon-gamma-mediated signaling pathway GO:0060333 9.26 CD44 HLA-DRB1 ICAM1 VCAM1
29 leukocyte migration GO:0050900 9.02 CD44 ICAM1 MIF SELE TNF

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.7 CD44 CX3CL1 HLA-DRB1 ICAM1 LTF MIF
2 cytokine activity GO:0005125 9.33 CX3CL1 MIF TNF
3 integrin binding GO:0005178 8.8 CX3CL1 ICAM1 VCAM1

Sources for Rheumatoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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