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MCID: RHM014
MIFTS: 38

Rheumatoid Vasculitis

Categories: Bone diseases, Cardiovascular diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Rheumatoid Vasculitis

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MalaCards integrated aliases for Rheumatoid Vasculitis:

Name: Rheumatoid Vasculitis 53 55 72 33

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

ICD10 33 M05.2
UMLS 72 C0240903
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Summaries for Rheumatoid Vasculitis

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MalaCards based summary : Rheumatoid Vasculitis is related to vasculitis and scleritis. An important gene associated with Rheumatoid Vasculitis is SELE (Selectin E), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Interferon gamma signaling. Affiliated tissues include skin, endothelial and monocytes, and related phenotypes are cellular and hematopoietic system

Wikipedia : 75 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

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Related Diseases for Rheumatoid Vasculitis

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Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.8 VCAM1 TNF SELE ICAM1 CX3CL1
2 scleritis 30.7 TNF SELE
3 lymphocytic vasculitis 30.3 VCAM1 SELE ICAM1
4 central nervous system vasculitis 30.2 TNF HLA-DRB1
5 rheumatic disease 30.1 VCAM1 TNF HLA-DRB1
6 glomerulonephritis 29.9 VCAM1 MIF ICAM1
7 synovitis 29.9 VCAM1 TNF SELE ICAM1
8 vascular disease 29.3 VCAM1 TNF SELE REN
9 rheumatoid arthritis 29.2 VCAM1 TNF SELE MIF ICAM1 HLA-DRB1
10 systemic lupus erythematosus 29.0 VCAM1 TNF SELE ICAM1 HLA-DRB1
11 heterophyiasis 10.6 SELE ICAM1
12 retinitis pigmentosa 60 10.6 TNF SELE
13 hymenolepiasis 10.6 SELE ICAM1
14 plummer's disease 10.5 SELE ICAM1
15 cortical thymoma 10.5 VCAM1 ICAM1
16 poliomyelitis 10.5 TNF ICAM1
17 endophthalmitis 10.5 SELE ICAM1
18 immune-complex glomerulonephritis 10.5 VCAM1 ICAM1
19 lichen disease 10.5 TNF ICAM1
20 brachydactyly, type e2 10.5 VCAM1 ICAM1
21 pustulosis palmaris et plantaris 10.5 TNF SELE
22 intestine carcinoma in situ 10.5 ICAM1 CD44
23 beryllium disease 10.5 TNF HLA-DRB1
24 listeria meningitis 10.5 TNF CX3CL1
25 streptococcal meningitis 10.5 TNF CD44
26 chronic beryllium disease 10.5 TNF HLA-DRB1
27 warthin tumor 10.4 VCAM1 CD44
28 leukocyte adhesion deficiency, type i 10.4 SELE ICAM1
29 limbal stem cell deficiency 10.4 VCAM1 ICAM1
30 erythema multiforme 10.4 TNF ICAM1
31 colon carcinoma in situ 10.4 ICAM1 CD44
32 grange syndrome 10.4 VCAM1 SELE
33 endometritis 10.4 TNF SELE
34 nontuberculous mycobacterial lung disease 10.4 TNF HLA-DRB1
35 systemic onset juvenile idiopathic arthritis 10.4 TNF MIF
36 sympathetic ophthalmia 10.4 TNF HLA-DRB1
37 microscopic colitis 10.4 TNF HLA-DRB1
38 aseptic meningitis 10.4 TNF CD44
39 lichen sclerosus 10.4 HLA-DRB1 CD44
40 alveolar echinococcosis 10.3 TNF HLA-DRB1
41 hypersensitivity reaction type iii disease 10.3 TNF SELE ICAM1
42 plasmodium vivax malaria 10.3 TNF SELE ICAM1
43 cutaneous lupus erythematosus 10.3 TNF SELE ICAM1
44 allergic contact dermatitis 10.3 TNF SELE ICAM1
45 arteriosclerosis obliterans 10.3 VCAM1 ICAM1
46 contact dermatitis 10.3 TNF SELE ICAM1
47 pityriasis rosea 10.3 HLA-DRB1 CX3CL1
48 localized scleroderma 10.3 VCAM1 TNF SELE
49 shwartzman phenomenon 10.3 VCAM1 TNF ICAM1
50 glaucomatocyclitic crisis 10.3 TNF HLA-DRB1

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to Rheumatoid Vasculitis
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Symptoms & Phenotypes for Rheumatoid Vasculitis

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MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 CD44 CX3CL1 ICAM1 LTF MIF SELE
2 hematopoietic system MP:0005397 10.02 CD44 CX3CL1 ICAM1 LTF MIF REN
3 cardiovascular system MP:0005385 10.01 CD44 CX3CL1 ICAM1 REN SELE SRF
4 homeostasis/metabolism MP:0005376 9.96 CD44 CX3CL1 ICAM1 LTF MIF REN
5 immune system MP:0005387 9.85 CD44 CX3CL1 ICAM1 LTF MIF REN
6 neoplasm MP:0002006 9.35 CD44 ICAM1 LTF MIF TNF
7 normal MP:0002873 9.1 CD44 LTF MIF REN SELE SRF
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Drugs & Therapeutics for Rheumatoid Vasculitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Multicenter, Post-Market Clinical Follow-Up Study to Evaluate the Safety and Effectiveness of the JOURNEY™ II XR Total Knee System Recruiting NCT03136887

Search NIH Clinical Center for Rheumatoid Vasculitis

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Genetic Tests for Rheumatoid Vasculitis

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Anatomical Context for Rheumatoid Vasculitis

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MalaCards organs/tissues related to Rheumatoid Vasculitis:

41
Skin, Endothelial, Monocytes, Colon, Liver, Neutrophil, Retina
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Publications for Rheumatoid Vasculitis

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Articles related to Rheumatoid Vasculitis:

(show top 50) (show all 357)
# Title Authors PMID Year
1
ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis. 9 38
9059140 1997
2
Anti-lactoferrin autoantibodies: relation between epitopes and iron-binding domain. 9 38
8864834 1996
3
Gout masquerading as rheumatoid vasculitis. 9 38
8182655 1994
4
[Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. 9 38
8009014 1993
5
Glucocorticoid-Sensitive Paroxysmal Atrial Fibrillation, Sick Sinus Syndrome, and Mitral Regurgitation in a Patient with Malignant Rheumatoid Vasculitis. 38
31292399 2019
6
Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre-Rheumatoid Arthritis Prevention. 38
31196641 2019
7
Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes and Adverse Events. 38
31203225 2019
8
A case of rheumatoid vasculitis with acquired reactive perforating collagenosis. 38
27846744 2019
9
Cutaneous diffuse large B-cell lymphoma mimicking rheumatoid vasculitis. 38
31081032 2019
10
Small vessel multi-organ vasculitis and marantic endocarditis complicating rheumatoid arthritis. 38
31070579 2019
11
[Rare erosive arthritis and dermatitis syndrome in Whipple's disease]. 38
30719572 2019
12
Acute Pulmonary Hypertension Crisis after Adalimumab Reduction in Rheumatoid Vasculitis. 38
30773522 2019
13
A Vanishing Entity: Rheumatoid Vasculitis. 38
30006132 2018
14
Detrimental Effects of Endovascular Intervention in Active Rheumatoid Vasculitis. 38
29984217 2018
15
Abatacept as a Therapeutic Option for Rheumatoid Vasculitis. 38
29930884 2018
16
Skin manifestations of rheumatoid arthritis. 38
29368864 2018
17
In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent. 38
29128969 2018
18
Pyoderma gangrenosum and pyogenic arthritis presenting as severe sepsis in a rheumatoid arthritis patient treated with golimumab. 38
29075910 2018
19
Rheumatoid Arthritis: A Brief Overview of the Treatment. 38
30173215 2018
20
Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides. 38
28752373 2017
21
Clinical utility of anti-C1q antibody in primary and secondary vasculitic conditions. 38
29114186 2017
22
Current clinical evidence of tocilizumab for the treatment of ANCA-associated vasculitis: a prospective case series for microscopic polyangiitis in a combination with corticosteroids and literature review. 38
28733791 2017
23
A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. 38
28581281 2017
24
Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace. 38
28631066 2017
25
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? 38
28293454 2017
26
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia. 38
28539558 2017
27
Incidence and classification of cutaneous manifestations in rheumatoid arthritis. 38
27886444 2016
28
Rheumatoid vasculitis: early presentation of rheumatoid arthritis. 38
27873751 2016
29
Refractory rheumatoid vasculitis-a therapeutic dilemma. 38
28031846 2016
30
Refractory rheumatoid vasculitis. 38
28031844 2016
31
Vasculitis and inflammatory arthritis. 38
27964796 2016
32
New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab. 38
27052429 2016
33
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. 38
27672862 2016
34
Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. 38
26955985 2016
35
A case of rheumatoid vasculitis. 38
27037329 2016
36
Burning vasculitis. 38
27118745 2016
37
Skin Signs of Rheumatoid Arthritis and its Therapy-Induced Cutaneous Side Effects. 38
26649439 2016
38
[Pathology of Vasculitic Neuropathies]. 38
27001771 2016
39
Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna. A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis. 38
26555550 2016
40
The use of muscle biopsy in the diagnosis of systemic vasculitis affecting small to medium-sized vessels: a prospective evaluation in Japan. 38
26448516 2016
41
Recurrent Stenosis of the Ileum Caused by Rheumatoid Vasculitis. 38
27041172 2016
42
Rheumatoid vasculitis - Case report. 38
25772654 2015
43
The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. 38
26106958 2015
44
Rheumatoid vasculitis: going, going, but not yet gone. 38
25952359 2015
45
The dramatic effect of dapsone on cutaneous bullous and pustular rheumatoid vasculitis on the sole. 38
25865233 2015
46
Vasculitis associated with connective tissue diseases. 38
25732106 2015
47
New insight into the rheumatoid vasculitis. 38
26402981 2015
48
[Rheumatoid vasculitis of the central nervous system]. 38
25637081 2015
49
Rheumatoid Vasculitis. 38
26278313 2015
50
Rheumatoid vasculitis: an update. 38
25405822 2015
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Variations for Rheumatoid Vasculitis

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Expression for Rheumatoid Vasculitis

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Search GEO for disease gene expression data for Rheumatoid Vasculitis.
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Pathways for Rheumatoid Vasculitis

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Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 13.12 VCAM1 TNF ICAM1 HLA-DRB1 CD44
2
Interferon gamma signaling 66
Show member pathways
 12.3 VCAM1 ICAM1 HLA-DRB1 CD44
3
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.18 VCAM1 SELE ICAM1 CD44
4
Human T-cell leukemia virus 1 infection 37
12.11 VCAM1 TNF SRF ICAM1 HLA-DRB1
5
Cell surface interactions at the vascular wall 66
Show member pathways
 12.02 SELE MIF CD44
6
ECM-receptor interaction 37
Show member pathways
 11.95 VCAM1 ICAM1 CD44
7
Cell adhesion molecules (CAMs) 37
11.92 VCAM1 SELE ICAM1 HLA-DRB1
8
Fluid shear stress and atherosclerosis 37
11.88 VCAM1 TNF SELE ICAM1
9
Adhesion 4
11.84 VCAM1 ICAM1 CD44
10
Spinal Cord Injury 1
11.82 TNF MIF ICAM1
11
Interleukin-4 and 13 signaling 66
11.79 VCAM1 TNF ICAM1
12
NF-kappa B signaling pathway 37
11.72 VCAM1 TNF ICAM1
13
Hematopoietic cell lineage 37
11.71 TNF HLA-DRB1 CD44
14
AGE-RAGE signaling pathway in diabetic complications 37
11.71 VCAM1 TNF SELE ICAM1
15
Rheumatoid arthritis 37
11.67 TNF ICAM1 HLA-DRB1
16
TNF signaling pathway 37
11.4 VCAM1 TNF SELE ICAM1 CX3CL1
17
Thromboxane A2 receptor signaling 1
11.31 VCAM1 SELE ICAM1
18
Malaria 37
11.25 VCAM1 TNF SELE ICAM1
19
Cytokines and Inflammatory Response 1
11.07 TNF HLA-DRB1
20
African trypanosomiasis 37
11.02 VCAM1 TNF SELE ICAM1
21
Cellular roles of Anthrax toxin 1
10.93 VCAM1 TNF
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.82 VCAM1 TNF SELE MIF ICAM1
23
LDL Oxidation in Atherogenesis 64
10.7 VCAM1 TNF ICAM1
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GO Terms for Rheumatoid Vasculitis

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Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 VCAM1 MIF LTF ICAM1 HLA-DRB1 CD44
2 extracellular space GO:0005615 9.56 VCAM1 TNF SELE REN MIF LTF
3 external side of plasma membrane GO:0009897 9.46 VCAM1 TNF ICAM1 HLA-DRB1
4 membrane raft GO:0045121 9.43 TNF SELE ICAM1
5 cell surface GO:0009986 9.23 VCAM1 TNF MIF LTF ICAM1 HLA-DRB1

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.95 VCAM1 SELE ICAM1 CX3CL1 CD44
2 cytokine-mediated signaling pathway GO:0019221 9.86 VCAM1 TNF ICAM1 CX3CL1
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.81 TNF LTF CX3CL1
4 response to hypoxia GO:0001666 9.81 VCAM1 SRF ICAM1
5 extracellular matrix organization GO:0030198 9.8 VCAM1 TNF ICAM1 CD44
6 inflammatory response GO:0006954 9.8 TNF SELE MIF CX3CL1 CD44
7 cellular response to tumor necrosis factor GO:0071356 9.79 VCAM1 ICAM1 CX3CL1
8 cell-matrix adhesion GO:0007160 9.77 VCAM1 SRF CD44
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.76 MIF ICAM1 CD44
10 response to lipopolysaccharide GO:0032496 9.76 VCAM1 SELE REN ICAM1
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.74 TNF MIF CD44
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 TNF LTF ICAM1 CX3CL1
13 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.65 TNF CX3CL1
14 negative regulation of interleukin-6 production GO:0032715 9.65 TNF CX3CL1
15 cell aging GO:0007569 9.65 MIF ICAM1
16 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.65 VCAM1 SELE ICAM1
17 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.65 TNF MIF ICAM1 CX3CL1 CD44
18 positive regulation of cytokine secretion GO:0050715 9.64 TNF MIF
19 microglial cell activation GO:0001774 9.63 TNF CX3CL1
20 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.62 MIF CD44
21 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF CD44
22 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.61 MIF CD44
23 angiogenesis involved in wound healing GO:0060055 9.6 SRF CX3CL1
24 leukocyte migration involved in inflammatory response GO:0002523 9.58 SELE CX3CL1
25 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 TNF ICAM1
26 leukocyte cell-cell adhesion GO:0007159 9.54 VCAM1 SELE ICAM1
27 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.52 TNF MIF
28 membrane to membrane docking GO:0022614 9.51 VCAM1 ICAM1
29 leukocyte tethering or rolling GO:0050901 9.5 VCAM1 TNF SELE
30 interferon-gamma-mediated signaling pathway GO:0060333 9.46 VCAM1 ICAM1 HLA-DRB1 CD44
31 leukocyte migration GO:0050900 9.35 TNF SELE MIF ICAM1 CD44
32 cell-cell adhesion GO:0098609 9.02 VCAM1 SRF ICAM1 CX3CL1 CD44

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.33 SELE ICAM1 CD44
2 chemoattractant activity GO:0042056 9.26 MIF CX3CL1
3 cytokine activity GO:0005125 9.13 TNF MIF CX3CL1
4 integrin binding GO:0005178 8.8 VCAM1 ICAM1 CX3CL1
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Sources for Rheumatoid Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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