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MCID: RHM014
MIFTS: 37

Rheumatoid Vasculitis

Categories: Bone diseases, Cardiovascular diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Rheumatoid Vasculitis

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MalaCards integrated aliases for Rheumatoid Vasculitis:

Name: Rheumatoid Vasculitis 52 54 71 32

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

ICD10 32 M05.2
UMLS 71 C0240903
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Summaries for Rheumatoid Vasculitis

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MalaCards based summary : Rheumatoid Vasculitis is related to scleritis and central nervous system vasculitis. An important gene associated with Rheumatoid Vasculitis is SELE (Selectin E), and among its related pathways/superpathways are Measles and Interferon gamma signaling. Affiliated tissues include skin, endothelial and lung, and related phenotypes are cardiovascular system and cellular

Wikipedia : 74 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

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Related Diseases for Rheumatoid Vasculitis

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Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 scleritis 30.3 TNF SELE
2 central nervous system vasculitis 29.9 TNF HLA-DRB1
3 crescentic glomerulonephritis 29.9 VCAM1 SELE ICAM1
4 vasculitis 29.9 VCAM1 TNF SELE LTF ICAM1 CX3CL1
5 rheumatic disease 29.8 VCAM1 TNF HLA-DRB1
6 glomerulonephritis 29.8 VCAM1 MIF ICAM1
7 polyarteritis nodosa 29.8 VCAM1 SELE ICAM1 HLA-DRB1
8 synovitis 29.8 VCAM1 TNF SELE ICAM1
9 interstitial lung disease 29.8 TNF ICAM1 CD44
10 autoimmune disease 29.6 VCAM1 TNF MIF HLA-DRB1
11 arthritis 29.4 VCAM1 TNF MIF ICAM1 HLA-DRB1
12 vascular disease 28.9 VCAM1 TNF SELE REN ICAM1
13 myocardial infarction 28.7 VCAM1 TNF SELE REN ICAM1
14 diabetes mellitus 28.3 VCAM1 TNF SELE REN ICAM1 HLA-DRB1
15 rheumatoid arthritis 27.8 VCAM1 TNF SRF SELE MIF ICAM1
16 systemic lupus erythematosus 26.6 VCAM1 TNF SELE MIF LTF ICAM1
17 diabetic peripheral angiopathy 10.4 SELE ICAM1
18 heterophyiasis 10.4 SELE ICAM1
19 pustulosis palmaris et plantaris 10.4 TNF SELE
20 plummer's disease 10.4 SELE ICAM1
21 limbal stem cell deficiency 10.3 VCAM1 ICAM1
22 grange syndrome 10.3 VCAM1 SELE
23 african tick-bite fever 10.3 TNF SELE
24 hypersensitivity reaction type iii disease 10.3 TNF SELE
25 beryllium disease 10.3 TNF HLA-DRB1
26 warthin tumor 10.3 VCAM1 CD44
27 chronic beryllium disease 10.3 TNF HLA-DRB1
28 nontuberculous mycobacterial lung disease 10.3 TNF HLA-DRB1
29 mononeuritis multiplex 10.3
30 background diabetic retinopathy 10.3 VCAM1 ICAM1
31 palindromic rheumatism 10.3 TNF HLA-DRB1
32 chorioretinitis 10.3 TNF CX3CL1
33 post-thrombotic syndrome 10.3 VCAM1 ICAM1
34 macular retinal edema 10.3 TNF ICAM1
35 idiopathic neutropenia 10.2 TNF HLA-DRB1
36 toxicodendron dermatitis 10.2 TNF SELE ICAM1
37 endophthalmitis 10.2 TNF SELE ICAM1
38 miller fisher syndrome 10.2 TNF SRF
39 cutaneous lupus erythematosus 10.2 TNF SELE ICAM1
40 henoch-schoenlein purpura 10.2 VCAM1 ICAM1
41 allergic contact dermatitis 10.2 TNF SELE ICAM1
42 contact dermatitis 10.2 TNF SELE ICAM1
43 limb ischemia 10.2 TNF SELE ICAM1
44 alveolar echinococcosis 10.2 TNF HLA-DRB1
45 localized scleroderma 10.2 VCAM1 TNF SELE
46 macular degeneration, age-related, 9 10.2 VCAM1 SELE ICAM1
47 pityriasis rosea 10.2 HLA-DRB1 CX3CL1
48 mooren's ulcer 10.2 VCAM1 SELE ICAM1
49 oral lichen planus 10.2 VCAM1 ICAM1
50 leukostasis 10.2 VCAM1 SELE ICAM1

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to Rheumatoid Vasculitis
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Symptoms & Phenotypes for Rheumatoid Vasculitis

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MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 CD44 CX3CL1 ICAM1 REN SELE SRF
2 cellular MP:0005384 9.97 CD44 CX3CL1 ICAM1 LTF MIF SELE
3 hematopoietic system MP:0005397 9.96 CD44 CX3CL1 ICAM1 LTF MIF REN
4 homeostasis/metabolism MP:0005376 9.85 CD44 CX3CL1 ICAM1 LTF MIF REN
5 immune system MP:0005387 9.65 CD44 CX3CL1 ICAM1 LTF MIF REN
6 neoplasm MP:0002006 9.02 CD44 ICAM1 LTF MIF TNF
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Drugs & Therapeutics for Rheumatoid Vasculitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Multicenter, Post-Market Clinical Follow-Up Study to Evaluate the Safety and Effectiveness of the JOURNEY™ II XR Total Knee System Recruiting NCT03136887

Search NIH Clinical Center for Rheumatoid Vasculitis

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Genetic Tests for Rheumatoid Vasculitis

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Anatomical Context for Rheumatoid Vasculitis

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MalaCards organs/tissues related to Rheumatoid Vasculitis:

40
Skin, Endothelial, Lung, Liver, Bone, B Cells, Eye
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Publications for Rheumatoid Vasculitis

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Articles related to Rheumatoid Vasculitis:

(show top 50) (show all 362)
# Title Authors PMID Year
1
ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis. 54 61
9059140 1997
2
Anti-lactoferrin autoantibodies: relation between epitopes and iron-binding domain. 54 61
8864834 1996
3
Gout masquerading as rheumatoid vasculitis. 54 61
8182655 1994
4
[Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. 54 61
8009014 1993
5
Marked Effectiveness of Intravenous Immunoglobulin Therapy Against Intractable Lower Leg Ulcers in Two Patients With Rheumatoid Vasculitis. 61
32015258 2020
6
Cutaneous diffuse large B-cell lymphoma mimicking rheumatoid vasculitis. 61
31081032 2020
7
Glucocorticoid-sensitive Paroxysmal Atrial Fibrillation, Sick Sinus Syndrome, and Mitral Regurgitation in a Patient with Malignant Rheumatoid Vasculitis. 61
31292399 2019
8
Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades: A Case Report. 61
31735796 2019
9
Rheumatoid Vasculitis: Is It Always a Late Manifestation of Rheumatoid Arthritis? 61
31728237 2019
10
Intracerebral Hemorrhage in a Patient with Untreated Rheumatoid Arthritis: Case Report and Literature Review. 61
31534869 2019
11
Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre-Rheumatoid Arthritis Prevention. 61
31196641 2019
12
Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes, and Adverse Events. 61
31203225 2019
13
A case of rheumatoid vasculitis with acquired reactive perforating collagenosis. 61
27846744 2019
14
Small vessel multi-organ vasculitis and marantic endocarditis complicating rheumatoid arthritis. 61
31070579 2019
15
[Rare erosive arthritis and dermatitis syndrome in Whipple's disease]. 61
30719572 2019
16
Acute Pulmonary Hypertension Crisis after Adalimumab Reduction in Rheumatoid Vasculitis. 61
30773522 2019
17
Vasculitic neuropathy associated with Rheumatoid Arthritis, a case report. 61
31723390 2019
18
A Vanishing Entity: Rheumatoid Vasculitis. 61
30006132 2018
19
Detrimental Effects of Endovascular Intervention in Active Rheumatoid Vasculitis. 61
29984217 2018
20
Abatacept as a Therapeutic Option for Rheumatoid Vasculitis. 61
29930884 2018
21
Skin manifestations of rheumatoid arthritis. 61
29368864 2018
22
In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent. 61
29128969 2018
23
Pyoderma gangrenosum and pyogenic arthritis presenting as severe sepsis in a rheumatoid arthritis patient treated with golimumab. 61
29075910 2018
24
Rheumatoid Arthritis: A Brief Overview of the Treatment. 61
30173215 2018
25
Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides. 61
28752373 2017
26
Clinical utility of anti-C1q antibody in primary and secondary vasculitic conditions. 61
29114186 2017
27
Current clinical evidence of tocilizumab for the treatment of ANCA-associated vasculitis: a prospective case series for microscopic polyangiitis in a combination with corticosteroids and literature review. 61
28733791 2017
28
A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. 61
28581281 2017
29
Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace. 61
28631066 2017
30
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? 61
28293454 2017
31
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia. 61
28539558 2017
32
Incidence and classification of cutaneous manifestations in rheumatoid arthritis. 61
27886444 2016
33
Rheumatoid vasculitis: early presentation of rheumatoid arthritis. 61
27873751 2016
34
Refractory rheumatoid vasculitis-a therapeutic dilemma. 61
28031846 2016
35
Refractory rheumatoid vasculitis. 61
28031844 2016
36
Vasculitis and inflammatory arthritis. 61
27964796 2016
37
New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab. 61
27052429 2016
38
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. 61
27672862 2016
39
A case of rheumatoid vasculitis. 61
27037329 2016
40
Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. 61
26955985 2016
41
Skin Signs of Rheumatoid Arthritis and its Therapy-Induced Cutaneous Side Effects. 61
26649439 2016
42
Burning vasculitis. 61
27118745 2016
43
[Pathology of Vasculitic Neuropathies]. 61
27001771 2016
44
Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna. A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis. 61
26555550 2016
45
The use of muscle biopsy in the diagnosis of systemic vasculitis affecting small to medium-sized vessels: a prospective evaluation in Japan. 61
26448516 2016
46
Recurrent Stenosis of the Ileum Caused by Rheumatoid Vasculitis. 61
27041172 2016
47
Rheumatoid vasculitis - Case report. 61
25772654 2015
48
The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. 61
26106958 2015
49
Rheumatoid vasculitis: going, going, but not yet gone. 61
25952359 2015
50
The dramatic effect of dapsone on cutaneous bullous and pustular rheumatoid vasculitis on the sole. 61
25865233 2015
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Variations for Rheumatoid Vasculitis

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Expression for Rheumatoid Vasculitis

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Search GEO for disease gene expression data for Rheumatoid Vasculitis.
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Pathways for Rheumatoid Vasculitis

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Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Measles 36
Show member pathways
 12.61 TNF ICAM1 HLA-DRB1 CD44
2
Interferon gamma signaling 65
Show member pathways
 12.3 VCAM1 ICAM1 HLA-DRB1 CD44
3
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.18 VCAM1 SELE ICAM1 CD44
4
Human T-cell leukemia virus 1 infection 36
12.12 TNF SRF ICAM1 HLA-DRB1
5
Cell surface interactions at the vascular wall 65
Show member pathways
 12.03 SELE MIF CD44
6
ECM-receptor interaction 36
Show member pathways
 11.95 VCAM1 ICAM1 CD44
7
Cell adhesion molecules (CAMs) 36
11.9 VCAM1 SELE ICAM1 HLA-DRB1
8
Fluid shear stress and atherosclerosis 36
11.85 VCAM1 TNF SELE ICAM1
9
Adhesion 4
11.84 VCAM1 ICAM1 CD44
10
Spinal Cord Injury 1
11.82 TNF MIF ICAM1
11
Interleukin-4 and 13 signaling 65
11.79 VCAM1 TNF ICAM1
12
NF-kappa B signaling pathway 36
11.73 VCAM1 TNF ICAM1
13
Hematopoietic cell lineage 36
11.71 TNF HLA-DRB1 CD44
14
Rheumatoid arthritis 36
11.67 TNF ICAM1 HLA-DRB1
15
AGE-RAGE signaling pathway in diabetic complications 36
11.67 VCAM1 TNF SELE ICAM1
16
TNF signaling pathway 36
11.4 VCAM1 TNF SELE ICAM1 CX3CL1
17
Thromboxane A2 receptor signaling 1
11.29 VCAM1 SELE ICAM1
18
Malaria 36
11.26 VCAM1 TNF SELE ICAM1
19
Cytokines and Inflammatory Response 1
11.07 TNF HLA-DRB1
20
African trypanosomiasis 36
11.02 VCAM1 TNF SELE ICAM1
21
Cellular roles of Anthrax toxin 1
10.93 VCAM1 TNF
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.82 VCAM1 TNF SELE MIF ICAM1
23
LDL Oxidation in Atherogenesis 63
10.7 VCAM1 TNF ICAM1
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GO Terms for Rheumatoid Vasculitis

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Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 VCAM1 TNF SELE REN MIF ICAM1
2 extracellular space GO:0005615 9.56 VCAM1 TNF SELE REN MIF LTF
3 external side of plasma membrane GO:0009897 9.46 VCAM1 TNF ICAM1 HLA-DRB1
4 cell surface GO:0009986 9.23 VCAM1 TNF MIF LTF ICAM1 HLA-DRB1

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 MIF LTF CX3CL1 CD44
2 cell adhesion GO:0007155 9.93 VCAM1 SELE ICAM1 CX3CL1 CD44
3 cytokine-mediated signaling pathway GO:0019221 9.85 VCAM1 TNF ICAM1 CX3CL1
4 extracellular matrix organization GO:0030198 9.83 VCAM1 TNF ICAM1 CD44
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.82 TNF LTF CX3CL1
6 response to hypoxia GO:0001666 9.81 VCAM1 SRF ICAM1
7 negative regulation of cell migration GO:0030336 9.81 SRF MIF CX3CL1
8 cellular response to tumor necrosis factor GO:0071356 9.8 VCAM1 ICAM1 CX3CL1
9 inflammatory response GO:0006954 9.8 TNF SELE MIF CX3CL1 CD44
10 cell-matrix adhesion GO:0007160 9.77 VCAM1 SRF CD44
11 response to lipopolysaccharide GO:0032496 9.76 VCAM1 SELE REN ICAM1
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 MIF ICAM1 CD44
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.73 TNF MIF CD44
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 TNF LTF ICAM1 CX3CL1
15 positive regulation of cytokine secretion GO:0050715 9.66 TNF MIF
16 cell aging GO:0007569 9.65 MIF ICAM1
17 microglial cell activation GO:0001774 9.65 TNF CX3CL1
18 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.65 VCAM1 SELE ICAM1
19 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.62 MIF CD44
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 TNF CD44
21 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.61 MIF CD44
22 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.61 TNF ICAM1
23 angiogenesis involved in wound healing GO:0060055 9.6 SRF CX3CL1
24 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF SRF
25 leukocyte migration involved in inflammatory response GO:0002523 9.57 SELE CX3CL1
26 interferon-gamma-mediated signaling pathway GO:0060333 9.56 VCAM1 ICAM1 HLA-DRB1 CD44
27 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.55 TNF MIF ICAM1 CX3CL1 CD44
28 leukocyte cell-cell adhesion GO:0007159 9.54 VCAM1 SELE ICAM1
29 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.51 TNF MIF
30 leukocyte tethering or rolling GO:0050901 9.5 VCAM1 TNF SELE
31 membrane to membrane docking GO:0022614 9.49 VCAM1 ICAM1
32 leukocyte migration GO:0050900 9.35 TNF SELE MIF ICAM1 CD44
33 cell-cell adhesion GO:0098609 9.02 VCAM1 SRF ICAM1 CX3CL1 CD44

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.13 SELE ICAM1 CD44
2 integrin binding GO:0005178 8.8 VCAM1 ICAM1 CX3CL1
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Sources for Rheumatoid Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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