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MCID: RHM014
MIFTS: 37

Rheumatoid Vasculitis

Categories: Bone diseases, Cardiovascular diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Rheumatoid Vasculitis

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MalaCards integrated aliases for Rheumatoid Vasculitis:

Name: Rheumatoid Vasculitis 52 54 71 32

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

ICD10 32 M05.2
UMLS 71 C0240903
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Summaries for Rheumatoid Vasculitis

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MalaCards based summary : Rheumatoid Vasculitis is related to scleritis and central nervous system vasculitis. An important gene associated with Rheumatoid Vasculitis is SELE (Selectin E), and among its related pathways/superpathways are Measles and Interferon gamma signaling. Affiliated tissues include skin, endothelial and monocytes, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

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Related Diseases for Rheumatoid Vasculitis

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Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 scleritis 30.2 TNF SELE
2 central nervous system vasculitis 29.9 TNF HLA-DRB1
3 vasculitis 29.8 VCAM1 TNF SELE LTF ICAM1 CX3CL1
4 crescentic glomerulonephritis 29.8 VCAM1 SELE ICAM1
5 glomerulonephritis 29.8 VCAM1 MIF ICAM1
6 polyarteritis nodosa 29.8 VCAM1 SELE ICAM1 HLA-DRB1
7 peritonitis 29.8 VCAM1 TNF ICAM1
8 synovitis 29.8 VCAM1 TNF SELE ICAM1
9 interstitial lung disease 29.7 TNF ICAM1 CD44
10 autoimmune disease 29.6 VCAM1 TNF MIF HLA-DRB1
11 arthritis 29.4 VCAM1 TNF MIF ICAM1 HLA-DRB1
12 vascular disease 28.8 VCAM1 TNF SELE REN ICAM1
13 myocardial infarction 28.7 VCAM1 TNF SELE REN ICAM1
14 diabetes mellitus 28.3 VCAM1 TNF SELE REN ICAM1 HLA-DRB1
15 rheumatoid arthritis 27.8 VCAM1 TNF SRF SELE MIF ICAM1
16 diabetic peripheral angiopathy 10.4 SELE ICAM1
17 heterophyiasis 10.4 SELE ICAM1
18 pustulosis palmaris et plantaris 10.3 TNF SELE
19 plummer's disease 10.3 SELE ICAM1
20 background diabetic retinopathy 10.3 TNF ICAM1
21 limbal stem cell deficiency 10.3 VCAM1 ICAM1
22 african tick-bite fever 10.3 TNF SELE
23 mononeuritis multiplex 10.3
24 funisitis 10.3 TNF SELE
25 beryllium disease 10.3 TNF HLA-DRB1
26 chronic beryllium disease 10.3 TNF HLA-DRB1
27 warthin tumor 10.3 VCAM1 CD44
28 nontuberculous mycobacterial lung disease 10.3 TNF HLA-DRB1
29 metal allergy 10.3 TNF HLA-DRB1
30 palindromic rheumatism 10.2 TNF HLA-DRB1
31 chorioretinitis 10.2 TNF CX3CL1
32 idiopathic neutropenia 10.2 TNF HLA-DRB1
33 post-thrombotic syndrome 10.2 VCAM1 ICAM1
34 toxicodendron dermatitis 10.2 TNF SELE ICAM1
35 whipple disease 10.2 TNF HLA-DRB1
36 endophthalmitis 10.2 TNF SELE ICAM1
37 cutaneous lupus erythematosus 10.2 TNF SELE ICAM1
38 leptospirosis 10.2 TNF SELE ICAM1
39 miller fisher syndrome 10.2 TNF SRF
40 allergic contact dermatitis 10.2 TNF SELE ICAM1
41 contact dermatitis 10.2 TNF SELE ICAM1
42 macular retinal edema 10.2 TNF ICAM1
43 limb ischemia 10.2 TNF SELE ICAM1
44 localized scleroderma 10.2 VCAM1 TNF SELE
45 macular degeneration, age-related, 9 10.2 VCAM1 SELE ICAM1
46 oral lichen planus 10.2 VCAM1 ICAM1
47 alveolar echinococcosis 10.2 TNF HLA-DRB1
48 mooren's ulcer 10.2 VCAM1 SELE ICAM1
49 dengue disease 10.1 VCAM1 TNF ICAM1
50 pityriasis rosea 10.1 HLA-DRB1 CX3CL1

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to Rheumatoid Vasculitis
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Symptoms & Phenotypes for Rheumatoid Vasculitis

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MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 CD44 CX3CL1 ICAM1 LTF MIF SELE
2 hematopoietic system MP:0005397 10.02 CD44 CX3CL1 ICAM1 LTF MIF REN
3 cardiovascular system MP:0005385 10.01 CD44 CX3CL1 ICAM1 REN SELE SRF
4 homeostasis/metabolism MP:0005376 9.96 CD44 CX3CL1 ICAM1 LTF MIF REN
5 immune system MP:0005387 9.85 CD44 CX3CL1 ICAM1 LTF MIF REN
6 neoplasm MP:0002006 9.35 CD44 ICAM1 LTF MIF TNF
7 normal MP:0002873 9.1 CD44 LTF MIF REN SELE SRF
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Drugs & Therapeutics for Rheumatoid Vasculitis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Multicenter, Post-Market Clinical Follow-Up Study to Evaluate the Safety and Effectiveness of the JOURNEY™ II XR Total Knee System Active, not recruiting NCT03136887

Search NIH Clinical Center for Rheumatoid Vasculitis

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Genetic Tests for Rheumatoid Vasculitis

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Anatomical Context for Rheumatoid Vasculitis

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MalaCards organs/tissues related to Rheumatoid Vasculitis:

40
Skin, Endothelial, Monocytes, Colon, Liver, Neutrophil, Retina
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Publications for Rheumatoid Vasculitis

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Articles related to Rheumatoid Vasculitis:

(show top 50) (show all 363)
# Title Authors PMID Year
1
ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis. 61 54
9059140 1997
2
Anti-lactoferrin autoantibodies: relation between epitopes and iron-binding domain. 61 54
8864834 1996
3
Gout masquerading as rheumatoid vasculitis. 54 61
8182655 1994
4
[Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. 54 61
8009014 1993
5
Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes, and Adverse Events. 61
31203225 2020
6
Rheumatoid vasculitis: study of 41 cases. 61
32147187 2020
7
Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades. 61
31735796 2020
8
Marked Effectiveness of Intravenous Immunoglobulin Therapy Against Intractable Lower Leg Ulcers in Two Patients With Rheumatoid Vasculitis. 61
32015258 2020
9
Cutaneous diffuse large B-cell lymphoma mimicking rheumatoid vasculitis. 61
31081032 2020
10
Glucocorticoid-sensitive Paroxysmal Atrial Fibrillation, Sick Sinus Syndrome, and Mitral Regurgitation in a Patient with Malignant Rheumatoid Vasculitis. 61
31292399 2019
11
Rheumatoid Vasculitis: Is It Always a Late Manifestation of Rheumatoid Arthritis? 61
31728237 2019
12
Intracerebral Hemorrhage in a Patient with Untreated Rheumatoid Arthritis: Case Report and Literature Review. 61
31534869 2019
13
Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre-Rheumatoid Arthritis Prevention. 61
31196641 2019
14
A case of rheumatoid vasculitis with acquired reactive perforating collagenosis. 61
27846744 2019
15
Small vessel multi-organ vasculitis and marantic endocarditis complicating rheumatoid arthritis. 61
31070579 2019
16
[Rare erosive arthritis and dermatitis syndrome in Whipple's disease]. 61
30719572 2019
17
Vasculitic neuropathy associated with Rheumatoid Arthritis, a case report. 61
31723390 2019
18
Acute Pulmonary Hypertension Crisis after Adalimumab Reduction in Rheumatoid Vasculitis. 61
30773522 2019
19
A Vanishing Entity: Rheumatoid Vasculitis. 61
30006132 2018
20
Detrimental Effects of Endovascular Intervention in Active Rheumatoid Vasculitis. 61
29984217 2018
21
Abatacept as a Therapeutic Option for Rheumatoid Vasculitis. 61
29930884 2018
22
Skin manifestations of rheumatoid arthritis. 61
29368864 2018
23
In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent. 61
29128969 2018
24
Pyoderma gangrenosum and pyogenic arthritis presenting as severe sepsis in a rheumatoid arthritis patient treated with golimumab. 61
29075910 2018
25
Rheumatoid Arthritis: A Brief Overview of the Treatment. 61
30173215 2018
26
Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides. 61
28752373 2017
27
Clinical utility of anti-C1q antibody in primary and secondary vasculitic conditions. 61
29114186 2017
28
Current clinical evidence of tocilizumab for the treatment of ANCA-associated vasculitis: a prospective case series for microscopic polyangiitis in a combination with corticosteroids and literature review. 61
28733791 2017
29
A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. 61
28581281 2017
30
Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace. 61
28631066 2017
31
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? 61
28293454 2017
32
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia. 61
28539558 2017
33
Incidence and classification of cutaneous manifestations in rheumatoid arthritis. 61
27886444 2016
34
Rheumatoid vasculitis: early presentation of rheumatoid arthritis. 61
27873751 2016
35
Refractory rheumatoid vasculitis-a therapeutic dilemma. 61
28031846 2016
36
Refractory rheumatoid vasculitis. 61
28031844 2016
37
Vasculitis and inflammatory arthritis. 61
27964796 2016
38
New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab. 61
27052429 2016
39
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. 61
27672862 2016
40
A case of rheumatoid vasculitis. 61
27037329 2016
41
Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. 61
26955985 2016
42
Skin Signs of Rheumatoid Arthritis and its Therapy-Induced Cutaneous Side Effects. 61
26649439 2016
43
Burning vasculitis. 61
27118745 2016
44
[Pathology of Vasculitic Neuropathies]. 61
27001771 2016
45
Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna. A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis. 61
26555550 2016
46
The use of muscle biopsy in the diagnosis of systemic vasculitis affecting small to medium-sized vessels: a prospective evaluation in Japan. 61
26448516 2016
47
Recurrent Stenosis of the Ileum Caused by Rheumatoid Vasculitis. 61
27041172 2016
48
Rheumatoid vasculitis - Case report. 61
25772654 2015
49
The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. 61
26106958 2015
50
Rheumatoid vasculitis: going, going, but not yet gone. 61
25952359 2015
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Variations for Rheumatoid Vasculitis

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Expression for Rheumatoid Vasculitis

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Search GEO for disease gene expression data for Rheumatoid Vasculitis.
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Pathways for Rheumatoid Vasculitis

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Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Measles 36
Show member pathways
 12.61 TNF ICAM1 HLA-DRB1 CD44
2
Interferon gamma signaling 65
Show member pathways
 12.3 VCAM1 ICAM1 HLA-DRB1 CD44
3
Development VEGF signaling via VEGFR2 - generic cascades 22
Show member pathways
 12.18 VCAM1 SELE ICAM1 CD44
4
Human T-cell leukemia virus 1 infection 36
12.12 TNF SRF ICAM1 HLA-DRB1
5
Cell surface interactions at the vascular wall 65
Show member pathways
 12.03 SELE MIF CD44
6
ECM-receptor interaction 36
Show member pathways
 11.95 VCAM1 ICAM1 CD44
7
Cell adhesion molecules (CAMs) 36
11.9 VCAM1 SELE ICAM1 HLA-DRB1
8
Fluid shear stress and atherosclerosis 36
11.85 VCAM1 TNF SELE ICAM1
9
Adhesion 4
11.84 VCAM1 ICAM1 CD44
10
Spinal Cord Injury 1
11.82 TNF MIF ICAM1
11
Interleukin-4 and 13 signaling 65
11.79 VCAM1 TNF ICAM1
12
NF-kappa B signaling pathway 36
11.74 VCAM1 TNF ICAM1
13
Hematopoietic cell lineage 36
11.71 TNF HLA-DRB1 CD44
14
Rheumatoid arthritis 36
11.67 TNF ICAM1 HLA-DRB1
15
AGE-RAGE signaling pathway in diabetic complications 36
11.67 VCAM1 TNF SELE ICAM1
16
TNF signaling pathway 36
11.4 VCAM1 TNF SELE ICAM1 CX3CL1
17
Thromboxane A2 receptor signaling 1
11.29 VCAM1 SELE ICAM1
18
Malaria 36
11.26 VCAM1 TNF SELE ICAM1
19
Cytokines and Inflammatory Response 1
11.07 TNF HLA-DRB1
20
African trypanosomiasis 36
11.02 VCAM1 TNF SELE ICAM1
21
Cellular roles of Anthrax toxin 1
10.93 VCAM1 TNF
22
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 10.82 VCAM1 TNF SELE MIF ICAM1
23
LDL Oxidation in Atherogenesis 63
10.7 VCAM1 TNF ICAM1
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GO Terms for Rheumatoid Vasculitis

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Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.97 VCAM1 TNF SELE REN MIF ICAM1
2 integral component of plasma membrane GO:0005887 9.63 VCAM1 TNF SELE ICAM1 HLA-DRB1 CD44
3 extracellular space GO:0005615 9.61 VCAM1 TNF SELE REN MIF LTF
4 external side of plasma membrane GO:0009897 9.56 VCAM1 TNF ICAM1 HLA-DRB1
5 cell surface GO:0009986 9.23 VCAM1 TNF MIF LTF ICAM1 HLA-DRB1

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.94 MIF LTF CX3CL1 CD44
2 cell adhesion GO:0007155 9.93 VCAM1 SELE ICAM1 CX3CL1 CD44
3 cytokine-mediated signaling pathway GO:0019221 9.85 VCAM1 TNF ICAM1 CX3CL1
4 extracellular matrix organization GO:0030198 9.83 VCAM1 TNF ICAM1 CD44
5 positive regulation of protein phosphorylation GO:0001934 9.82 TNF MIF HLA-DRB1
6 response to lipopolysaccharide GO:0032496 9.81 SELE REN ICAM1
7 negative regulation of cell migration GO:0030336 9.81 SRF MIF CX3CL1
8 inflammatory response GO:0006954 9.8 TNF SELE MIF CX3CL1 CD44
9 cell-matrix adhesion GO:0007160 9.76 VCAM1 SRF CD44
10 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.76 TNF LTF HLA-DRB1 CX3CL1
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.74 MIF ICAM1 CD44
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.73 TNF MIF CD44
13 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 TNF LTF ICAM1 CX3CL1
14 positive regulation of cytokine secretion GO:0050715 9.66 TNF MIF
15 microglial cell activation GO:0001774 9.65 TNF CX3CL1
16 cell aging GO:0007569 9.65 MIF ICAM1
17 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.65 VCAM1 SELE ICAM1
18 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.63 MIF CD44
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 TNF CD44
20 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.62 TNF ICAM1
21 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.61 MIF CD44
22 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.61 TNF MIF
23 angiogenesis involved in wound healing GO:0060055 9.6 SRF CX3CL1
24 leukocyte migration involved in inflammatory response GO:0002523 9.59 SELE CX3CL1
25 negative regulation of amyloid-beta clearance GO:1900222 9.58 TNF SRF
26 interferon-gamma-mediated signaling pathway GO:0060333 9.56 VCAM1 ICAM1 HLA-DRB1 CD44
27 leukocyte migration GO:0050900 9.55 TNF SELE MIF ICAM1 CD44
28 leukocyte cell-cell adhesion GO:0007159 9.54 VCAM1 SELE ICAM1
29 positive regulation of I-kappaB phosphorylation GO:1903721 9.51 TNF CX3CL1
30 leukocyte tethering or rolling GO:0050901 9.5 VCAM1 TNF SELE
31 membrane to membrane docking GO:0022614 9.49 VCAM1 ICAM1
32 cell-cell adhesion GO:0098609 9.35 VCAM1 SRF ICAM1 CX3CL1 CD44
33 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.1 TNF MIF ICAM1 HLA-DRB1 CX3CL1 CD44

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 VCAM1 ICAM1 CX3CL1
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Sources for Rheumatoid Vasculitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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