MCID: RHM014
MIFTS: 42

Rheumatoid Vasculitis

Categories: Bone diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Rheumatoid Vasculitis

MalaCards integrated aliases for Rheumatoid Vasculitis:

Name: Rheumatoid Vasculitis 54 56 74

Classifications:



External Ids:

ICD10 34 M05.2
UMLS 74 C0240903

Summaries for Rheumatoid Vasculitis

MalaCards based summary : Rheumatoid Vasculitis is related to vasculitis and glomerulonephritis. An important gene associated with Rheumatoid Vasculitis is LTF (Lactotransferrin), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Interferon gamma signaling. Affiliated tissues include skin, endothelial and salivary gland, and related phenotypes are cellular and hematopoietic system

Wikipedia : 77 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

Related Diseases for Rheumatoid Vasculitis

Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.9 CX3CL1 ICAM1 SELE TNF VCAM1
2 glomerulonephritis 29.7 ICAM1 MIF VCAM1
3 rheumatoid arthritis 29.5 HLA-DRB1 ICAM1 MIF SELE TNF VCAM1
4 critical limb ischemia 10.4 SELE TNF
5 scleritis 10.4 SELE TNF
6 retinitis pigmentosa 60 10.4 SELE TNF
7 heterophyiasis 10.4 ICAM1 SELE
8 hymenolepiasis 10.3 ICAM1 SELE
9 plummer's disease 10.3 ICAM1 SELE
10 cortical thymoma 10.3 ICAM1 VCAM1
11 endophthalmitis 10.3 ICAM1 SELE
12 poliomyelitis 10.3 ICAM1 TNF
13 brachydactyly, type e2 10.3 ICAM1 VCAM1
14 immune-complex glomerulonephritis 10.3 ICAM1 VCAM1
15 listeria meningitis 10.3 CX3CL1 TNF
16 leukocyte adhesion deficiency, type i 10.3 ICAM1 SELE
17 beryllium disease 10.3 HLA-DRB1 TNF
18 intestine carcinoma in situ 10.3 CD44 ICAM1
19 lichen disease 10.3 ICAM1 TNF
20 pustulosis palmaris et plantaris 10.3 SELE TNF
21 chronic beryllium disease 10.3 HLA-DRB1 TNF
22 streptococcal meningitis 10.3 CD44 TNF
23 limbal stem cell deficiency 10.3 ICAM1 VCAM1
24 erythema multiforme 10.3 ICAM1 TNF
25 endometritis 10.3 SELE TNF
26 arthritis 10.3
27 warthin tumor 10.3 CD44 VCAM1
28 grange syndrome 10.3 SELE VCAM1
29 colon carcinoma in situ 10.3 CD44 ICAM1
30 microscopic colitis 10.3 HLA-DRB1 TNF
31 sympathetic ophthalmia 10.3 HLA-DRB1 TNF
32 nontuberculous mycobacterial lung disease 10.2 HLA-DRB1 TNF
33 central nervous system vasculitis 10.2 HLA-DRB1 TNF
34 aseptic meningitis 10.2 CD44 TNF
35 hemorrhagic fever 10.2 HLA-DRB1 TNF
36 lichen sclerosus 10.2 CD44 HLA-DRB1
37 alveolar echinococcosis 10.2 HLA-DRB1 TNF
38 hypersensitivity reaction type iii disease 10.2 ICAM1 SELE TNF
39 plasmodium vivax malaria 10.2 ICAM1 SELE TNF
40 cutaneous lupus erythematosus 10.2 ICAM1 SELE TNF
41 allergic contact dermatitis 10.2 ICAM1 SELE TNF
42 contact dermatitis 10.2 ICAM1 SELE TNF
43 henoch-schoenlein purpura 10.2 ICAM1 VCAM1
44 pityriasis rosea 10.2 CX3CL1 HLA-DRB1
45 systemic onset juvenile idiopathic arthritis 10.2 MIF TNF
46 localized scleroderma 10.2 SELE TNF VCAM1
47 shwartzman phenomenon 10.2 ICAM1 TNF VCAM1
48 dermatitis, atopic 10.2 ICAM1 SELE TNF
49 lymphocytic vasculitis 10.2 ICAM1 SELE VCAM1
50 mooren's ulcer 10.2 ICAM1 SELE VCAM1

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to Rheumatoid Vasculitis

Symptoms & Phenotypes for Rheumatoid Vasculitis

MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 CD44 CX3CL1 ICAM1 LTF MIF SELE
2 hematopoietic system MP:0005397 10.02 CD44 CX3CL1 ICAM1 LTF MIF REN
3 cardiovascular system MP:0005385 10.01 CD44 CX3CL1 ICAM1 REN SELE SRF
4 homeostasis/metabolism MP:0005376 9.96 CD44 CX3CL1 ICAM1 LTF MIF REN
5 immune system MP:0005387 9.85 CD44 CX3CL1 ICAM1 LTF MIF REN
6 neoplasm MP:0002006 9.35 CD44 ICAM1 LTF MIF TNF
7 normal MP:0002873 9.1 CD44 LTF MIF REN SELE SRF

Drugs & Therapeutics for Rheumatoid Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Non-Interventional Study of RoActemra/Actemra in Patients With Moderate to Severe Rheumatoid Arthritis Completed NCT01672970
2 A Non-Interventional Study of Rheumatoid Arthritis Patients Treated With RoActemra/Actemra (Tocilizumab) in Monotherapy Completed NCT01705730 tocilizumab
3 A Non-interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Rheumatoid Arthritis Completed NCT01562327 Tocilizumab
4 A Non-Interventional Study in Patients With Moderate to Severe Rheumatoid Arthritis Treated With RoActemra/Actemra (Tocilizumab) Completed NCT01663506
5 JOURNEY II XR Safety and Effectiveness PMCF Recruiting NCT03136887

Search NIH Clinical Center for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

Anatomical Context for Rheumatoid Vasculitis

MalaCards organs/tissues related to Rheumatoid Vasculitis:

42
Skin, Endothelial, Salivary Gland, Colon, Bone, Neutrophil, Retina

Publications for Rheumatoid Vasculitis

Articles related to Rheumatoid Vasculitis:

(show top 50) (show all 148)
# Title Authors Year
1
Acute Pulmonary Hypertension Crisis after Adalimumab Reduction in Rheumatoid Vasculitis. ( 30773522 )
2019
2
Abatacept as a Therapeutic Option for Rheumatoid Vasculitis. ( 29930884 )
2018
3
Detrimental Effects of Endovascular Intervention in Active Rheumatoid Vasculitis. ( 29984217 )
2018
4
A Vanishing Entity: Rheumatoid Vasculitis. ( 30006132 )
2018
5
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? ( 28293454 )
2017
6
A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. ( 28581281 )
2017
7
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia. ( 28539558 )
2017
8
Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace. ( 28631066 )
2017
9
Recurrent Stenosis of the Ileum Caused by Rheumatoid Vasculitis. ( 27041172 )
2016
10
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. ( 27672862 )
2016
11
Rheumatoid vasculitis: early presentation of rheumatoid arthritis. ( 27873751 )
2016
12
New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab. ( 27052429 )
2016
13
Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. ( 26955985 )
2016
14
Refractory rheumatoid vasculitis-a therapeutic dilemma. ( 28031846 )
2016
15
A case of rheumatoid vasculitis with acquired reactive perforating collagenosis. ( 27846744 )
2016
16
A case of rheumatoid vasculitis. ( 27037329 )
2016
17
Refractory rheumatoid vasculitis. ( 28031844 )
2016
18
New insight into the rheumatoid vasculitis. ( 26402981 )
2015
19
Rheumatoid Vasculitis. ( 26278313 )
2015
20
The dramatic effect of dapsone on cutaneous bullous and pustular rheumatoid vasculitis on the sole. ( 25865233 )
2015
21
Rheumatoid vasculitis - Case report. ( 25772654 )
2015
22
Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna : A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis. ( 26555550 )
2015
23
The role of KIR2DL3/HLA-C*0802 in Brazilian patients with rheumatoid vasculitis. ( 26106958 )
2015
24
Rheumatoid vasculitis: going, going, but not yet gone. ( 25952359 )
2015
25
Severe gangrene accompanied by varicella zoster virus-related vasculitis mimicking rheumatoid vasculitis. ( 24761143 )
2014
26
Rheumatoid arthritis: Rheumatoid vasculitis--down but not out. ( 24595091 )
2014
27
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. ( 24533557 )
2014
28
Rheumatoid vasculitis: an update. ( 25405822 )
2014
29
Systemic rheumatoid vasculitis in the era of modern immunosuppressive therapy. ( 24108586 )
2014
30
Peripheral ulcerative keratitis as the presenting feature of systemic rheumatoid vasculitis without joint involvement. ( 24234515 )
2013
31
Successful treatment of rheumatoid vasculitis-associated skin ulcer with a TNF-I+ antagonist. ( 23557520 )
2013
32
Successful treatment of digital tip necrosis in rheumatoid vasculitis with anti-CD20 antibody rituximab. ( 23319024 )
2013
33
Tocilizumab improves systemic rheumatoid vasculitis with necrotizing crescentic glomerulonephritis. ( 23494445 )
2013
34
The rapid efficacy of abatacept in a patient with rheumatoid vasculitis. ( 22124545 )
2012
35
Foot ulcers caused by rheumatoid vasculitis in a patient with rheumatoid arthritis undergoing etanercept treatment. ( 23154729 )
2012
36
Association of HLA-DRB5*01 with protection against cutaneous manifestations of rheumatoid vasculitis in Brazilian patients. ( 22641591 )
2012
37
Elevated serum levels of macrophage migration inhibitory factor and their significant correlation with rheumatoid vasculitis disease activity. ( 21607712 )
2012
38
Cerebral rheumatoid vasculitis: a case report. ( 22974191 )
2012
39
Successful treatment with humanised anti-interleukin 6 receptor antibody for multidrug-refractory and anti-tumour necrosis factor-resistant systemic rheumatoid vasculitis. ( 21385558 )
2011
40
Case of severe liver damage after the induction of tocilizumab therapy for rheumatoid vasculitis. ( 21435128 )
2011
41
Rheumatoid vasculitis: vanishing menace or target for new treatments? ( 20842467 )
2010
42
Are anti-cyclic citrullinated peptide autoantibodies seromarkers for rheumatoid vasculitis in a cohort of patients with systemic vasculitis? ( 20107034 )
2010
43
Rheumatoid vasculitis of crural muscles confirmed by muscle biopsy in the absence of inflammatory myopathy: histologic and MRI study. ( 19639318 )
2010
44
Decline in rheumatoid vasculitis prevalence among US veterans: a retrospective cross-sectional study. ( 19714622 )
2009
45
Disseminated herpes zoster mimicking rheumatoid vasculitis in a rheumatoid arthritis patient on etanercept. ( 19648728 )
2009
46
Successful treatment of rheumatoid vasculitis-associated cutaneous ulcers using rituximab in two patients with rheumatoid arthritis. ( 18411212 )
2008
47
Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody. ( 18711097 )
2008
48
Nasal tip necrosis--an unusual presentation of rheumatoid vasculitis. ( 17318275 )
2007
49
A case of rheumatoid vasculitis involving the gastrointestinal tract in early disease. ( 17908700 )
2007
50
Systemic rheumatoid vasculitis: a review. ( 17023257 )
2006

Variations for Rheumatoid Vasculitis

Expression for Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for Rheumatoid Vasculitis

Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 CD44 HLA-DRB1 ICAM1 TNF VCAM1
2
Show member pathways
12.3 CD44 HLA-DRB1 ICAM1 VCAM1
3
Show member pathways
12.18 CD44 ICAM1 SELE VCAM1
4 12.11 HLA-DRB1 ICAM1 SRF TNF VCAM1
5
Show member pathways
12.03 CD44 MIF SELE
6
Show member pathways
11.94 CD44 ICAM1 VCAM1
7 11.92 HLA-DRB1 ICAM1 SELE VCAM1
8 11.88 ICAM1 SELE TNF VCAM1
9 11.84 CD44 ICAM1 VCAM1
10 11.82 ICAM1 MIF TNF
11 11.79 ICAM1 TNF VCAM1
12 11.71 CD44 HLA-DRB1 TNF
13 11.71 ICAM1 SELE TNF VCAM1
14 11.69 ICAM1 TNF VCAM1
15 11.66 HLA-DRB1 ICAM1 TNF
16 11.4 CX3CL1 ICAM1 SELE TNF VCAM1
17 11.31 ICAM1 SELE VCAM1
18 11.25 ICAM1 SELE TNF VCAM1
19 11.07 HLA-DRB1 TNF
20 11.02 ICAM1 SELE TNF VCAM1
21 10.93 TNF VCAM1
22
Show member pathways
10.82 ICAM1 MIF SELE TNF VCAM1
23 10.7 ICAM1 TNF VCAM1

GO Terms for Rheumatoid Vasculitis

Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 CD44 HLA-DRB1 ICAM1 LTF MIF VCAM1
2 extracellular space GO:0005615 9.56 CX3CL1 ICAM1 LTF MIF REN SELE
3 external side of plasma membrane GO:0009897 9.46 HLA-DRB1 ICAM1 TNF VCAM1
4 membrane raft GO:0045121 9.43 ICAM1 SELE TNF
5 cell surface GO:0009986 9.23 CD44 CX3CL1 HLA-DRB1 ICAM1 LTF MIF

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.95 CD44 CX3CL1 ICAM1 SELE VCAM1
2 cytokine-mediated signaling pathway GO:0019221 9.86 CX3CL1 ICAM1 TNF VCAM1
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.81 CX3CL1 LTF TNF
4 response to hypoxia GO:0001666 9.81 ICAM1 SRF VCAM1
5 extracellular matrix organization GO:0030198 9.8 CD44 ICAM1 TNF VCAM1
6 inflammatory response GO:0006954 9.8 CD44 CX3CL1 MIF SELE TNF
7 cellular response to tumor necrosis factor GO:0071356 9.79 CX3CL1 ICAM1 VCAM1
8 cell-matrix adhesion GO:0007160 9.77 CD44 SRF VCAM1
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.76 CD44 ICAM1 MIF
10 response to lipopolysaccharide GO:0032496 9.76 ICAM1 REN SELE VCAM1
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.74 CD44 MIF TNF
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CX3CL1 ICAM1 LTF TNF
13 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.65 CX3CL1 TNF
14 cell aging GO:0007569 9.65 ICAM1 MIF
15 negative regulation of interleukin-6 production GO:0032715 9.65 CX3CL1 TNF
16 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.65 ICAM1 SELE VCAM1
17 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.65 CD44 CX3CL1 ICAM1 MIF TNF
18 positive regulation of cytokine secretion GO:0050715 9.64 MIF TNF
19 microglial cell activation GO:0001774 9.63 CX3CL1 TNF
20 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.62 CD44 MIF
21 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.61 CD44 MIF
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 CD44 TNF
23 angiogenesis involved in wound healing GO:0060055 9.6 CX3CL1 SRF
24 leukocyte migration involved in inflammatory response GO:0002523 9.58 CX3CL1 SELE
25 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.54 ICAM1 TNF
26 leukocyte cell-cell adhesion GO:0007159 9.54 ICAM1 SELE VCAM1
27 membrane to membrane docking GO:0022614 9.52 ICAM1 VCAM1
28 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.51 MIF TNF
29 leukocyte tethering or rolling GO:0050901 9.5 SELE TNF VCAM1
30 interferon-gamma-mediated signaling pathway GO:0060333 9.46 CD44 HLA-DRB1 ICAM1 VCAM1
31 leukocyte migration GO:0050900 9.35 CD44 ICAM1 MIF SELE TNF
32 cell-cell adhesion GO:0098609 9.02 CD44 CX3CL1 ICAM1 SRF VCAM1

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.33 CD44 ICAM1 SELE
2 chemoattractant activity GO:0042056 9.26 CX3CL1 MIF
3 cytokine activity GO:0005125 9.13 CX3CL1 MIF TNF
4 integrin binding GO:0005178 8.8 CX3CL1 ICAM1 VCAM1

Sources for Rheumatoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....