MCID: RHM014
MIFTS: 37

Rheumatoid Vasculitis

Categories: Bone diseases, Cardiovascular diseases, Rare diseases

Aliases & Classifications for Rheumatoid Vasculitis

MalaCards integrated aliases for Rheumatoid Vasculitis:

Name: Rheumatoid Vasculitis 20 54 71 32

Classifications:



External Ids:

ICD10 32 M05.2
UMLS 71 C0240903

Summaries for Rheumatoid Vasculitis

MalaCards based summary : Rheumatoid Vasculitis is related to vasculitis and scleritis. An important gene associated with Rheumatoid Vasculitis is SELE (Selectin E), and among its related pathways/superpathways are Measles and Interferon gamma signaling. Affiliated tissues include endothelial, monocytes and retina, and related phenotypes are cellular and hematopoietic system

Wikipedia : 74 Rheumatoid vasculitis is skin condition that is a typical feature of rheumatoid arthritis, presenting as... more...

Related Diseases for Rheumatoid Vasculitis

Diseases related to Rheumatoid Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 vasculitis 30.2 VCAM1 TNF SELE LTF ICAM1 CX3CL1
2 scleritis 30.2 TNF SELE
3 polyarteritis nodosa 30.1 VCAM1 SELE ICAM1 HLA-DRB1
4 central nervous system vasculitis 30.1 TNF HLA-DRB1
5 glomerulonephritis 29.9 VCAM1 MIF ICAM1
6 autoimmune disease 29.8 VCAM1 TNF MIF HLA-DRB1
7 crescentic glomerulonephritis 29.8 VCAM1 SELE ICAM1
8 synovitis 29.8 VCAM1 TNF SELE ICAM1
9 arthritis 29.8 VCAM1 TNF MIF ICAM1 HLA-DRB1
10 interstitial lung disease 29.7 TNF ICAM1 CD44
11 rheumatoid arthritis 28.5 VCAM1 TNF SRF SELE MIF ICAM1
12 mononeuritis multiplex 10.3
13 beryllium disease 10.3 TNF HLA-DRB1
14 chronic beryllium disease 10.3 TNF HLA-DRB1
15 nontuberculous mycobacterial lung disease 10.3 TNF HLA-DRB1
16 palindromic rheumatism 10.3 TNF HLA-DRB1
17 critical illness polyneuropathy 10.3 TNF SELE
18 heterophyiasis 10.3 SELE ICAM1
19 inflammatory and toxic neuropathy 10.3 TNF SELE
20 pustulosis palmaris et plantaris 10.3 TNF SELE
21 idiopathic neutropenia 10.3 TNF HLA-DRB1
22 african tick-bite fever 10.2 TNF SELE
23 background diabetic retinopathy 10.2 TNF ICAM1
24 plummer's disease 10.2 SELE ICAM1
25 macular degeneration, age-related, 9 10.2 VCAM1 ICAM1
26 alveolar echinococcosis 10.2 TNF HLA-DRB1
27 funisitis 10.2 TNF SELE
28 mooren's ulcer 10.2 VCAM1 ICAM1
29 limbal stem cell deficiency 10.2 VCAM1 ICAM1
30 cytomegalovirus retinitis 10.2 TNF HLA-DRB1
31 histoplasmosis 10.2 TNF HLA-DRB1
32 pityriasis rosea 10.2 HLA-DRB1 CX3CL1
33 purpura 10.2
34 chorioretinitis 10.2 TNF CX3CL1
35 post-thrombotic syndrome 10.2 VCAM1 ICAM1
36 intermediate uveitis 10.2 TNF HLA-DRB1
37 trachoma 10.2 TNF HLA-DRB1
38 aphthous stomatitis 10.2 TNF SELE HLA-DRB1
39 miller fisher syndrome 10.2 TNF SRF
40 lichen disease 10.1 TNF ICAM1
41 tungiasis 10.1 TNF MIF
42 guillain-barre syndrome 10.1 TNF ICAM1 HLA-DRB1
43 ocular cicatricial pemphigoid 10.1 MIF HLA-DRB1
44 rheumatic fever 10.1 TNF ICAM1 HLA-DRB1
45 oral lichen planus 10.1 VCAM1 ICAM1
46 toxicodendron dermatitis 10.1 TNF SELE ICAM1
47 endophthalmitis 10.1 TNF SELE ICAM1
48 sclerosing cholangitis 10.1 TNF ICAM1 HLA-DRB1
49 cholangitis 10.1 TNF ICAM1 HLA-DRB1
50 microscopic colitis 10.1 TNF HLA-DRB1

Graphical network of the top 20 diseases related to Rheumatoid Vasculitis:



Diseases related to Rheumatoid Vasculitis

Symptoms & Phenotypes for Rheumatoid Vasculitis

MGI Mouse Phenotypes related to Rheumatoid Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.02 CD44 CX3CL1 ICAM1 LTF MIF SELE
2 hematopoietic system MP:0005397 10.02 CD44 CX3CL1 ICAM1 LTF MIF REN
3 cardiovascular system MP:0005385 10.01 CD44 CX3CL1 ICAM1 REN SELE SRF
4 homeostasis/metabolism MP:0005376 9.96 CD44 CX3CL1 ICAM1 LTF MIF REN
5 immune system MP:0005387 9.85 CD44 CX3CL1 ICAM1 LTF MIF REN
6 neoplasm MP:0002006 9.35 CD44 ICAM1 LTF MIF TNF
7 normal MP:0002873 9.1 CD44 LTF MIF REN SELE SRF

Drugs & Therapeutics for Rheumatoid Vasculitis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective, Multicenter, Post-Market Clinical Follow-Up Study to Evaluate the Safety and Effectiveness of the JOURNEY™ II XR Total Knee System Active, not recruiting NCT03136887

Search NIH Clinical Center for Rheumatoid Vasculitis

Genetic Tests for Rheumatoid Vasculitis

Anatomical Context for Rheumatoid Vasculitis

MalaCards organs/tissues related to Rheumatoid Vasculitis:

40
Endothelial, Monocytes, Retina, T Cells, Neutrophil, Colon, Salivary Gland

Publications for Rheumatoid Vasculitis

Articles related to Rheumatoid Vasculitis:

(show top 50) (show all 369)
# Title Authors PMID Year
1
ICAM-1, E-selectin, and TNF alpha expression in labial salivary glands of patients with rheumatoid vasculitis. 61 54
9059140 1997
2
Anti-lactoferrin autoantibodies: relation between epitopes and iron-binding domain. 54 61
8864834 1996
3
Gout masquerading as rheumatoid vasculitis. 54 61
8182655 1994
4
[Is the expression of TNF-alpha and cell adhesion molecules a marker of development of rheumatoid vasculitis?]. 61 54
8009014 1993
5
Interferon III-related IL28RA variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub-phenotypes. 61
33269531 2021
6
Efficacy and safety of rituximab in peripheral ulcerative keratitis associated with rheumatoid arthritis. 61
33510042 2021
7
Concomitant Large Loculated Pleural and Pericardial Effusions in a Patient with Rheumatoid Arthritis on Methotrexate. 61
33482962 2020
8
Possible Cerebral Vasculitis in a Case with Rheumatoid Arthritis. 61
33087675 2020
9
Biological therapy in rheumatoid vasculitis: a systematic review. 61
33058033 2020
10
Rheumatoid vasculitis: study of 41 cases. 61
32147187 2020
11
Refractory rheumatoid vasculitis complicated by cytomegalovirus reactivation as a manifestation of immune reconstitution inflammatory syndrome. 61
32613063 2020
12
Leprosy mimicking rheumatoid vasculitis with scleromalacia perforans. 61
32624492 2020
13
Rituximab Therapy for Systemic Rheumatoid Vasculitis: Indications, Outcomes, and Adverse Events. 61
31203225 2020
14
Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades. 61
31735796 2020
15
Marked Effectiveness of Intravenous Immunoglobulin Therapy Against Intractable Lower Leg Ulcers in Two Patients With Rheumatoid Vasculitis. 61
32015258 2020
16
Cutaneous diffuse large B-cell lymphoma mimicking rheumatoid vasculitis. 61
31081032 2020
17
Glucocorticoid-sensitive Paroxysmal Atrial Fibrillation, Sick Sinus Syndrome, and Mitral Regurgitation in a Patient with Malignant Rheumatoid Vasculitis. 61
31292399 2019
18
Rheumatoid Vasculitis: Is It Always a Late Manifestation of Rheumatoid Arthritis? 61
31728237 2019
19
Intracerebral Hemorrhage in a Patient with Untreated Rheumatoid Arthritis: Case Report and Literature Review. 61
31534869 2019
20
Extra-articular Manifestations and Comorbidity in Rheumatoid Arthritis: Potential Impact of Pre-Rheumatoid Arthritis Prevention. 61
31196641 2019
21
A case of rheumatoid vasculitis with acquired reactive perforating collagenosis. 61
27846744 2019
22
Small vessel multi-organ vasculitis and marantic endocarditis complicating rheumatoid arthritis. 61
31070579 2019
23
[Rare erosive arthritis and dermatitis syndrome in Whipple's disease]. 61
30719572 2019
24
Acute Pulmonary Hypertension Crisis after Adalimumab Reduction in Rheumatoid Vasculitis. 61
30773522 2019
25
Vasculitic neuropathy associated with Rheumatoid Arthritis, a case report. 61
31723390 2019
26
A Vanishing Entity: Rheumatoid Vasculitis. 61
30006132 2018
27
Detrimental Effects of Endovascular Intervention in Active Rheumatoid Vasculitis. 61
29984217 2018
28
Skin manifestations of rheumatoid arthritis. 61
29368864 2018
29
Abatacept as a Therapeutic Option for Rheumatoid Vasculitis. 61
29930884 2018
30
In vasculitis of small muscular arteries, activation of vessel-infiltrating CD8 T cells seems to be antigen-independent. 61
29128969 2018
31
Pyoderma gangrenosum and pyogenic arthritis presenting as severe sepsis in a rheumatoid arthritis patient treated with golimumab. 61
29075910 2018
32
Rheumatoid Arthritis: A Brief Overview of the Treatment. 61
30173215 2018
33
Skin Manifestations of Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, and Spondyloarthritides. 61
28752373 2017
34
Clinical utility of anti-C1q antibody in primary and secondary vasculitic conditions. 61
29114186 2017
35
Current clinical evidence of tocilizumab for the treatment of ANCA-associated vasculitis: a prospective case series for microscopic polyangiitis in a combination with corticosteroids and literature review. 61
28733791 2017
36
A Case of Rheumatoid Vasculitis Involving Hepatic Artery in Early Rheumatoid Arthritis. 61
28581281 2017
37
Rheumatoid Vasculitis: A Diminishing Yet Devastating Menace. 61
28631066 2017
38
Can rheumatoid vasculitis predate a diagnosis of rheumatoid arthritis? 61
28293454 2017
39
A case of new-onset rheumatoid vasculitis becoming evident in the course of treatment for Pneumocystis jirovecii pneumonia. 61
28539558 2017
40
Incidence and classification of cutaneous manifestations in rheumatoid arthritis. 61
27886444 2016
41
Rheumatoid vasculitis: early presentation of rheumatoid arthritis. 61
27873751 2016
42
Refractory rheumatoid vasculitis-a therapeutic dilemma. 61
28031846 2016
43
Refractory rheumatoid vasculitis. 61
28031844 2016
44
New onset of rheumatoid vasculitis during abatacept therapy and subsequent improvement after rituximab. 61
27052429 2016
45
Vasculitis and inflammatory arthritis. 61
27964796 2016
46
Poster 94 Mononeuritis Multiplex Secondary to HCV Cryoglobulinemia and Rheumatoid Vasculitis: A Case Report. 61
27672862 2016
47
A case of rheumatoid vasculitis. 61
27037329 2016
48
Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis. 61
26955985 2016
49
Skin Signs of Rheumatoid Arthritis and its Therapy-Induced Cutaneous Side Effects. 61
26649439 2016
50
Burning vasculitis. 61
27118745 2016

Variations for Rheumatoid Vasculitis

Expression for Rheumatoid Vasculitis

Search GEO for disease gene expression data for Rheumatoid Vasculitis.

Pathways for Rheumatoid Vasculitis

Pathways related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 TNF ICAM1 HLA-DRB1 CD44
2
Show member pathways
12.32 VCAM1 ICAM1 HLA-DRB1 CD44
3
Show member pathways
12.18 VCAM1 SELE ICAM1 CD44
4 12.12 TNF SRF ICAM1 HLA-DRB1
5
Show member pathways
12.04 SELE MIF CD44
6
Show member pathways
11.96 VCAM1 ICAM1 CD44
7 11.91 VCAM1 SELE ICAM1 HLA-DRB1
8 11.85 VCAM1 ICAM1 CD44
9 11.85 VCAM1 TNF SELE ICAM1
10 11.83 TNF MIF ICAM1
11 11.8 VCAM1 TNF ICAM1
12 11.75 VCAM1 TNF ICAM1
13 11.72 TNF HLA-DRB1 CD44
14 11.68 TNF ICAM1 HLA-DRB1
15 11.67 VCAM1 TNF SELE ICAM1
16 11.51 VCAM1 TNF ICAM1
17 11.4 VCAM1 TNF SELE ICAM1 CX3CL1
18 11.29 VCAM1 SELE ICAM1
19 11.26 VCAM1 TNF SELE ICAM1
20 11.08 TNF HLA-DRB1
21 11.02 VCAM1 TNF SELE ICAM1
22 10.94 VCAM1 TNF
23
Show member pathways
10.82 VCAM1 TNF SELE MIF ICAM1
24 10.7 VCAM1 TNF ICAM1

GO Terms for Rheumatoid Vasculitis

Cellular components related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.85 VCAM1 TNF SELE REN MIF LTF
2 integral component of plasma membrane GO:0005887 9.73 VCAM1 TNF SELE ICAM1 HLA-DRB1 CD44
3 external side of plasma membrane GO:0009897 9.62 VCAM1 TNF ICAM1 HLA-DRB1
4 extracellular space GO:0005615 9.61 VCAM1 TNF SELE REN MIF LTF
5 cell surface GO:0009986 9.23 VCAM1 TNF MIF LTF ICAM1 HLA-DRB1

Biological processes related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.95 MIF LTF CX3CL1 CD44
2 cell adhesion GO:0007155 9.95 VCAM1 SELE ICAM1 CX3CL1 CD44
3 cytokine-mediated signaling pathway GO:0019221 9.86 VCAM1 TNF ICAM1 CX3CL1
4 extracellular matrix organization GO:0030198 9.84 VCAM1 TNF ICAM1 CD44
5 response to hypoxia GO:0001666 9.82 VCAM1 SRF ICAM1
6 negative regulation of cell migration GO:0030336 9.81 SRF MIF CX3CL1
7 cellular response to tumor necrosis factor GO:0071356 9.81 VCAM1 ICAM1 CX3CL1
8 inflammatory response GO:0006954 9.8 TNF SELE MIF CX3CL1 CD44
9 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.78 TNF LTF HLA-DRB1 CX3CL1
10 cell-matrix adhesion GO:0007160 9.77 VCAM1 SRF CD44
11 response to lipopolysaccharide GO:0032496 9.76 VCAM1 SELE REN ICAM1
12 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.75 MIF ICAM1 CD44
13 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.74 TNF MIF CD44
14 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 TNF LTF ICAM1 CX3CL1
15 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.67 VCAM1 SELE ICAM1
16 negative regulation of apoptotic signaling pathway GO:2001234 9.65 TNF CX3CL1
17 microglial cell activation GO:0001774 9.65 TNF CX3CL1
18 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF CD44
19 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.62 TNF ICAM1
20 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.62 MIF CD44
21 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 9.61 MIF CD44
22 leukocyte migration involved in inflammatory response GO:0002523 9.61 SELE CX3CL1
23 negative regulation of amyloid-beta clearance GO:1900222 9.6 TNF SRF
24 angiogenesis involved in wound healing GO:0060055 9.58 SRF CX3CL1
25 interferon-gamma-mediated signaling pathway GO:0060333 9.56 VCAM1 ICAM1 HLA-DRB1 CD44
26 leukocyte migration GO:0050900 9.55 TNF SELE MIF ICAM1 CD44
27 leukocyte cell-cell adhesion GO:0007159 9.54 VCAM1 SELE ICAM1
28 positive regulation of I-kappaB phosphorylation GO:1903721 9.52 TNF CX3CL1
29 membrane to membrane docking GO:0022614 9.51 VCAM1 ICAM1
30 leukocyte tethering or rolling GO:0050901 9.5 VCAM1 TNF SELE
31 cell-cell adhesion GO:0098609 9.35 VCAM1 SRF ICAM1 CX3CL1 CD44
32 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.1 TNF MIF ICAM1 HLA-DRB1 CX3CL1 CD44

Molecular functions related to Rheumatoid Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.8 VCAM1 ICAM1 CX3CL1

Sources for Rheumatoid Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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