Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: RHN004
MIFTS: 57

Rhinitis

Categories: Bone diseases, Respiratory diseases, Smell/Taste diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Rhinitis

About this section

MalaCards integrated aliases for Rhinitis:

Name: Rhinitis 12 29 54 43 15 17 71
Runny Nose 12

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Smell/Taste diseases Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4483
MeSH 43 D012220
NCIt 49 C34986
SNOMED-CT 67 70076002
UMLS 71 C0035455
Sources

Summaries for Rhinitis

About this section
Disease Ontology : 12 A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip.

MalaCards based summary : Rhinitis, also known as runny nose, is related to vasomotor rhinitis and chronic rhinitis, and has symptoms including rhinorrhea, sneezing and sinus congestion. An important gene associated with Rhinitis is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Zolmitriptan and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 74 Rhinitis, also known as coryza, is irritation and inflammation of the mucous membrane inside the nose.... more...

Sources

Related Diseases for Rhinitis

About this section

Diseases in the Rhinitis family:

Chronic Rhinitis

Diseases related to Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 620)
# Related Disease Score Top Affiliating Genes
1 vasomotor rhinitis 35.0 RNASE3 KNG1 IL5
2 chronic rhinitis 35.0 RNASE3 IL5 IL4 IL13 HRH1 EPX
3 ige responsiveness, atopic 33.9 RNASE3 IL5 IL4R IL4 IL13 IGHE
4 allergic rhinitis 33.8 VCAM1 RNASE3 NR3C1 NGF KNG1 IL5
5 pollen allergy 33.2 RNASE3 IL5 IL4R IL13 IGHE ICAM1
6 churg-strauss syndrome 33.0 RNASE3 IL5 CYSLTR1 CXCL8 CCL11
7 respiratory syncytial virus infectious disease 32.8 IL5 IL13 CCL5
8 allergic conjunctivitis 32.7 RNASE3 IL5 IL4 IL13 IGHE ICAM1
9 common cold 32.7 RNASE3 IL5 IL4 IL13 ICAM1 CYSLTR1
10 giant papillary conjunctivitis 32.6 RNASE3 IL4 CXCL8 CCL11
11 allergic asthma 32.4 VCAM1 RNASE3 IL5 IL4R IL4 IL13
12 dermatitis 32.2 IL5 IL4 IL13 IGHE CXCL8 CCL11
13 dermatitis, atopic 32.0 VCAM1 RNASE3 NGF IL5 IL4R IL4
14 cytokine deficiency 31.9 IL5 IL13
15 urticaria 31.9 RNASE3 IL5 IL4 IL13 IGHE HRH1
16 hypereosinophilic syndrome 31.6 RNASE3 IL5 IL4 IL13 IGHE EPX
17 conjunctivitis 31.6 RNASE3 IL5 IL4 IL13 IGHE ICAM1
18 respiratory allergy 31.5 RNASE3 IL5 IL4R IL4 IL13 CXCL8
19 sleep apnea 31.5 VCAM1 ICAM1 CXCL8
20 otitis media 31.4 RNASE3 IL5 IL4 IL13 IGHE ICAM1
21 food allergy 31.4 RNASE3 IL5 IL4R IL4 IL13 IGHE
22 gastroesophageal reflux 31.4 IL5 IL4 CXCL8 CCL11
23 bronchitis 31.2 RNASE3 IL5 IL4 IL13 IGHE CXCL8
24 proteasome-associated autoinflammatory syndrome 1 31.1 VCAM1 RNASE3 IL5 IL4 IL13 ICAM1
25 aspergillosis 31.1 IL5 IL4 EPX CXCL8 CCL5
26 drug allergy 31.1 IL5 IL4R IGHE CYP3A4
27 leprosy 3 31.0 IL5 IL4 CXCL8
28 contact dermatitis 31.0 NGF IL5 IL4 ICAM1 CXCL8
29 autoimmune disease 31.0 VCAM1 IL5 IL4 IL13 CXCL8 CCL5
30 angioedema 30.9 KNG1 IL5 IGHE HRH1
31 fibromyalgia 30.9 POMC NGF CXCL8
32 chlamydia 30.9 IL5 IL4 CXCL8
33 graves' disease 30.9 IL4 IL13 ICAM1 CCL5
34 intrinsic asthma 30.9 RNASE3 IL5 IL4 IL13 IGHE
35 milk allergy 30.8 RNASE3 IL5 IL4 IL13 IGHE
36 pulmonary disease, chronic obstructive 30.8 RNASE3 NR3C1 IL5 IL4 IL13 CXCL8
37 egg allergy 30.8 IL5 IL4 IL13 IGHE
38 lung disease 30.8 RNASE3 IL5 IL4 IL13 ICAM1 CXCL8
39 anxiety 30.8 POMC NR3C1 NGF CYP3A4
40 pneumonia 30.8 IL5 IL4 IL13 ICAM1 CXCL8 CCL5
41 allergic bronchopulmonary aspergillosis 30.8 IL5 IL4 IGHE EPX
42 irritable bowel syndrome 30.8 POMC NGF CXCL8
43 skin disease 30.8 RNASE3 IL5 IL4 IL13 ICAM1 HRH1
44 meningoencephalitis 30.8 NGF IL4 CCL5
45 latex allergy 30.8 RNASE3 IL5 IL4 IL13 IGHE
46 esophagitis, eosinophilic, 1 30.7 RNASE3 IL5 IL4 IL13 EPX CCL11
47 osteomyelitis 30.7 IL4 IL13 CXCL8 CCL5
48 chronic fatigue syndrome 30.7 POMC NR3C1 IL5 IL4 IL13 CXCL8
49 allergic contact dermatitis 30.7 IL5 IL4 ICAM1 CXCL8
50 peanut allergy 30.7 IL5 IL4 IL13 IGHE

Graphical network of the top 20 diseases related to Rhinitis:



Diseases related to Rhinitis
Sources

Symptoms & Phenotypes for Rhinitis

About this section

UMLS symptoms related to Rhinitis:


rhinorrhea, sneezing, sinus congestion, nasal congestion (finding), nasal irritation, posterior rhinorrhea

MGI Mouse Phenotypes related to Rhinitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.03 FOXJ1 HRH1 ICAM1 IL13 IL4 IL4R
2 hematopoietic system MP:0005397 9.93 CCL11 CCL5 EPX HRH1 ICAM1 IL13
3 immune system MP:0005387 9.77 CCL11 CCL5 CYSLTR1 EPX HRH1 ICAM1
4 respiratory system MP:0005388 9.23 CCL11 CYSLTR1 FOXJ1 IL13 IL4 IL4R
Sources

Drugs & Therapeutics for Rhinitis

About this section

Drugs for Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 359)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
2
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
3
Dexlansoprazole Approved, Investigational Phase 4 103577-45-3, 138530-94-6 9578005
4
Promethazine Approved, Investigational Phase 4 60-87-7 4927
5
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
6
Loratadine Approved, Investigational Phase 4 79794-75-5 3957
7
Desloratadine Approved, Investigational Phase 4 100643-71-8 124087
8
Levocetirizine Approved Phase 4 130018-77-8 1549000
9
Fexofenadine Approved, Investigational Phase 4 83799-24-0 3348
10
Montelukast Approved Phase 4 158966-92-8 5281040
11
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
12
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
13
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
14
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
15
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
16 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
17
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
18
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
19
Racepinephrine Approved Phase 4 329-65-7 838
20
Sodium citrate Approved, Investigational Phase 4 68-04-2
21
Adenosine Approved, Investigational Phase 4 58-61-7 60961
22
Ethanol Approved Phase 4 64-17-5 702
23
Doxazosin Approved Phase 4 74191-85-8 3157
24
Theophylline Approved Phase 4 58-55-9 2153
25
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
26
Prazosin Approved Phase 4 19216-56-9 4893
27
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
28
Cetirizine Approved Phase 4 83881-51-0 2678
29
Budesonide Approved Phase 4 51333-22-3 63006 5281004
30
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
31
mometasone furoate Approved, Investigational, Vet_approved Phase 4 83919-23-7
32
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
33
Resveratrol Investigational Phase 4 501-36-0 445154
34
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
35
Tranilast Investigational Phase 4 53902-12-8 93543
36 Serotonin 5-HT1 Receptor Agonists Phase 4
37 Serotonin Receptor Agonists Phase 4
38 Oxazolidinones Phase 4
39 Proton Pump Inhibitors Phase 4
40 Purple Butterbur Phase 4
41 Hypnotics and Sedatives Phase 4
42 Antiemetics Phase 4
43 Anesthetics, Local Phase 4
44 Adrenergic alpha-Antagonists Phase 4
45 Adrenergic alpha-1 Receptor Antagonists Phase 4
46 Cholinergic Agents Phase 4
47 Cholinergic Antagonists Phase 4
48 Leukotriene Antagonists Phase 4
49
Beclomethasone Phase 4 4419-39-0 20469
50
Salmeterol xinafoate Phase 4 94749-08-3 56801

Interventional clinical trials:

(show top 50) (show all 1287)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Zolmitriptan by Sublingual Administration in the Treatment of Cluster Headache: A Multi-center Randomized Cross-controlled Trial Unknown status NCT03377257 Phase 4 zolmitriptan by sublingual administration;zolmitriptan by oral
2 Comparison of the Effect of Montelukast and Cetirizine on Allergic Inflammation Measured by Exhaled Nitric Oxide Concentration in Children With Seasonal Allergic Rhinitis Unknown status NCT00488176 Phase 4 montelukast;cetirizine;montelukast and cetirizine;placebo
3 Immunological Mechanisms of Oralair® (5 Grass Mix Sublingual Allergen Immunotherapy Tablet) in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
4 Assessment of Effectiveness and Safety of Annual Sublingual Immunotherapy in Children With Bronchial Asthma and/or Allergic Rhinitis Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
5 A Randomized, Parallel, Double-blind, Multi-center, Comparative Study to Exploratively Evaluate the Efficacy and Safety of Cosalin® Monotherapy vs. Cosalin® and Xarlin® Combination Therapy in Patients With Allergic Rhinitis Unknown status NCT01062139 Phase 4 Xarlin (Levocetirizine);Cosalin (Petasites hybridus CO2 extract)
6 The Evaluation of Singulair for the Treatment of Non-Allergic Rhinitis Eosinophil Syndrome (NARES) Unknown status NCT00406094 Phase 4 montelukast;placebo
7 SINOL + MucoAdâ„¢ (SMAN) Evaluation Trial: A Double-Blind, Cross-Over Comparison of SINOL and SMAN in Subjects With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
8 AZE/FLU Nasal Spray on Symptom Control, Nasal Mediators and Nasal Hyperresponsiveness in Allergic Rhinitis (AR) Unknown status NCT02238353 Phase 4 azelastine + fluticasone;Placebo
9 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate. A Randomized Controlled Trial Unknown status NCT02278081 Phase 4 lansoprazole;placebo
10 Evaluating Factors Involved in Dymista's Superior Clinical Efficacy to Fluticasone Propionate in the Treatment of Seasonal Allergic Rhinitis Unknown status NCT02402465 Phase 4 Placebo;Fluticasone propionate;Fluticasone/Azelastine nasal spray
11 Real Life Proof-of-Concept Study to Assess the Effect of Methylcellulose as add-on "Seal" to the In-season Pharmacologic Rescue Treatment in Subjects With Allergic Rhinitis Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
12 Comparing Treatment Efficacy With High and Medium Dose of Fluticasone in Combination With Salmeterol in COPD Patients Unknown status NCT01657487 Phase 4 Fluticasone/Salmeterol high dose
13 Changes in Exhaled Breath Temperature During the Pollen Season in Subjects With Allergic Rhinoconjunctivitis Sensitized to Grasses and Effect of Sublingual Immunotherapy Unknown status NCT01785394 Phase 4 5 grass allergen extract
14 Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
15 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
16 Randomized, Double Blind, Parallel Group, Placebo Controlled, Multi-Center Study of the Efficacy and Safety of Zyrtec® (Cetirizine HCl) Syrup vs. Claritin® (Loratadine) Syrup vs. Placebo in Treatment of Children With Seasonal Allergic Rhinitis (SAR) Completed NCT02932774 Phase 4 Cetirizine;Loratadine
17 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Effect of Long-Term Treatment With Rhinocort Aqua (Budesonide) Nasal Spray in Children With Perennial Allergic Rhinitis. Completed NCT00641212 Phase 4 Budesonide;Placebo
18 Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis Completed NCT00894231 Phase 4 levocetirizine (Xyzal);placebo
19 A Comparison of Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine in the Treatment of Seasonal Allergic Rhinitis Completed NCT00502775 Phase 4 fluticasone furoate, fexofenadine
20 Safety and Efficacy of Olopatadine 0.6% and Azelastine 137 Mcg in Vasomotor Rhinitis Completed NCT00979615 Phase 4 Olopatadine HCL (Patanase) Nasal Spray, 0.6%;Azelastine HCl (Astelin) Nasal Spray, 137 mcg
21 Allergic Rhinitis Changes the Sinus Microbiome Completed NCT01852513 Phase 4 QNASL;Placebo nasal spray
22 Evaluation of the Sensory Attributes of Olopatadine 0.6% and Azelastine 137mcg Nasal Sprays in Patients w/Allergic Rhinitis Completed NCT00772304 Phase 4 Olopatadine 0.6% / Azelastine 137 mcg
23 A Comparison of Fluticasone Furoate Nasal Spray Versus Oral Fexofenadine in the Treatment of Seasonal Allergic Rhinitis Completed NCT00435461 Phase 4 Fluticasone furoate and fexofenadine
24 Evaluation of Efficacy, Using the Number of Comfortable Days and the Safety of Levocetirizine Dihydrochloride, Administered Once Daily in the Evening for 30 Days, to Subjects Suffering From Perennial Allergic Rhinitis to House Dust Mites Completed NCT00521131 Phase 4 Levocetirizine dihydrochloride
25 The Addition of Vitamin D to Fluticasone Propionate in the Management of Seasonal Allergic Rhinitis Completed NCT01103934 Phase 4 Vitamin D3;Placebo;Fluticasone Propionate
26 A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine 5 mg Once Daily Given for 2 Weeks in Subjects 18 yr of Age and Older With Seasonal Allergic Rhinitis Completed NCT00621959 Phase 4 levocetirizine dihydrochloride;placebo
27 A Double-masked, Randomized, Parallel Group, Comparison of Olopatadine 0.6% and Fluticasone Proprionate 50mcg Nasal Sprays in a Two Week Seasonal Allergic Rhinitis Trial Completed NCT00691665 Phase 4 Olopatadine HCL Nasal Spray, 0.6%;Fluticasone Propionate Nasal Spray, 50 mcg
28 Efficacy of Mite Allergen Vaccine Among Thai Patients With Allergic Rhinitis Completed NCT01115595 Phase 4
29 A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicenter Study to Evaluate the Efficacy and Safety of Once-Daily Intranasal Administration of Fluticasone Furoate Nasal Spray 110mcg in Adult and Adolescent Subjects 12 Years of Age and Older With Perennial Allergic Rhinitis (PAR) Completed NCT00609674 Phase 4 Fluticasone furoate nasal spray;Placebo
30 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Multicenter, Two-Year Study to Evaluate the Ocular Safety of Once-Daily, Fluticasone Furoate Nasal Spray 110mcg in Adults and Adolescents 12 Years of Age and Older With Perennial Allergic Rhinitis Completed NCT00682643 Phase 4 fluticasone furoate nasal spray;vehicle placebo nasal spray
31 Trial to Compare the Efficacy and Safety of Levocetirizine 5 mg od and Fexofenadine 120 mg od in Reducing Symptoms of Seasonal Allergic Rhinitis in Grass Pollen Sensitized Adults Completed NCT00542607 Phase 4 levocetirizine dihydrochloride
32 A Pilot, Open, Monocenter, Randomized Two Parallel Groups, Clinical Efficacy Trial: Comparison Continuous Versus on Demand Regimen of Treatment With Levocetirizine 5 mg Oral Tablets, Once a Day, in Adults Suffering From Persistent Allergic Rhinitis (PER) Over 6 Months Completed NCT00160680 Phase 4 Levocetirizine
33 A Multicentre, Double-blind, Parallel, Randomized, Placebo-controlled Study : Evaluation of the Efficacy and Safety of Levocetirizine 5 mg and Desloratadine 5 mg Administered Orally as Capsules Once Daily, in the Morning, Over 2 Weeks in Patients Suffering From Allergic Rhinitis (AR) Completed NCT00160589 Phase 4 Levocetirizine
34 A Monocenter, Double-blind, Randomized Trial, With Two Parallel Groups Comparing the Clinical Efficacy of Levocetirizine 5 mg Capsules and Desloratadine 5 mg Capsules Taken Once a Day Over 3 Weeks of Treatment in Adult Subjects Suffering From Seasonal Allergic Rhinitis (SAR) Due to Grass Pollen Completed NCT00160537 Phase 4 Levocetirizine
35 Evaluation of NasoNebâ„¢ Delivery of an Intranasal Steroid in the Treatment of Perennial Allergic Rhinitis Completed NCT01270256 Phase 4 Budesonide;Placebo
36 Effects of Hypertonic Saline Solution (NACL 3%+NAHCO3) on Nasal Inflammation in Children With Allergic Rhinitis. RinASol- Pilot Study (Allergic Rhinitis Solution) Completed NCT02729012 Phase 4 hypertonic saline solution (NACL 3%+NAHCO3)
37 Efficacy and Safety of Nasonex vs. Placebo in Subjects With SAR and Concomitant Asthma Completed NCT00070707 Phase 4 Mometasone;Placebo;Albuterol/Salbutamol
38 A Monitored Release Study On The Efficacy And Safety of Fexofenadine (Telfast®) 30mg Pediatric Tablets On Filipino Children Aged 6 To 11 for The Relief of Perennial And Intermittent Allergic Rhinitis. Completed NCT00741897 Phase 4 Fexofenadine
39 A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Evaluating the Efficacy and Impact on Health-related Quality of Life of Levocetirizine 5 mg Once Daily Given for 2 Weeks in Subjects 18 yr of Age and Older With Seasonal Allergic Rhinitis Completed NCT00653224 Phase 4 levocetirizine dihydrochloride;placebo
40 Proteomic Profiling for Influenza Vaccination Completed NCT00133588 Phase 4
41 Prospective, Randomized, Controlled, Observer-Blind Trial to Measure the Efficacy, Safety and Immunogenicity of Trivalent Inactivated Influenza Vaccine and the Safety and Immunogenicity of Quadrivalent Meningococcal Polysaccharide Diphtheria Conjugate Vaccine in Pregnant Malian Women and Their Infants up to 6 Months of Age Completed NCT01430689 Phase 4
42 The Efficacy and Safety of Hyeonggaeyeongyo-tang for Chronic Rhinitis According to Pattern Identification in Korean Medicine Completed NCT02477293 Phase 4 Hyeonggaeyeongyo-tang
43 Molecular and Cellular Mechanism in Rhinitis Allergic Patients Treated With GRAZAX® Completed NCT02437786 Phase 4 GRAZAX
44 Korean Study of "Real-World" Montelukast Use in Mild Asthmatic Children With Concomitant Allergic Rhinitis Completed NCT00442559 Phase 4 montelukast sodium;inhaled corticosteroid
45 Montelukast as a Controller of Atopic Syndrome Completed NCT00559546 Phase 4 montelukast
46 Quality of Life in Asthma and Rhinitis Allergic With Singulair Completed NCT00380705 Phase 4 MK0476, Singulair, montelukast sodium / Duration of Treatment: 8 Weeks
47 Elaboration of Patient-friendly Treatment Strategy With Capsaicin Nasal Spray in Patients With Idiopathic Rhinitis Completed NCT02288156 Phase 4 Capsaicin;placebo
48 A Multi-center, Open-label, Non-comparative Study of the Relief of Nasal Symptoms and Tolerability in Subjects With Seasonal Allergic Rhinitis (SAR) Treated With Aerius. Completed NCT00805584 Phase 4 desloratadine
49 A Multi-Centre, Double-Blind, Randomised Comparison Of The Effects Of Desloratadine (Aerius®) And Placebo In The Relief Of Nasal Symptom Scores In Subjects With Seasonal Allergic Rhinitis (Sar) To Cypress Pollen Completed NCT00867191 Phase 4 Placebo;Desloratadine
50 Single-Center, Double-Blind, Randomized , Parallel Study Comparing Onset of Action, Efficacy & Safety of a Single-Dose of Fexofenadine HCl 180 mg vs Montelukast Na 10 mg & Placebo in Treating Seasonal Allergic Rhinitis Subjects in an Allergen Exposure Unit (Study I) Completed NCT00637611 Phase 4 Fexofenadine HCl

Search NIH Clinical Center for Rhinitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ephedra vulgaris preparation
Ephedrine
Ephedrine hydrochloride
Ephedrine sulfate
EPHEDRINE TANNATE
Hyoscyamine
Hyoscyamine hydrobromide
Hyoscyamine Sulfate
Naphazoline
Naphazoline Hydrochloride
Oxymetazoline
Oxymetazoline hydrochloride
Phenylpropanolamine

Cochrane evidence based reviews: rhinitis

Sources

Genetic Tests for Rhinitis

About this section

Genetic tests related to Rhinitis:

# Genetic test Affiliating Genes
1 Rhinitis 29
Sources

Anatomical Context for Rhinitis

About this section

MalaCards organs/tissues related to Rhinitis:

40
Testes, Skin, T Cells, Lung, Eye, Neutrophil, Pituitary
Sources

Publications for Rhinitis

About this section

Articles related to Rhinitis:

(show top 50) (show all 26967)
# Title Authors PMID Year
1
The role of mast cell-derived secreted phospholipases A2 in respiratory allergy. 54 61
20219624 2010
2
[Evaluating total serum IgE levels and peripheral eosinophil count in asthma and rhinitis]. 54 61
20502102 2010
3
Reduced helminth burden increases allergen skin sensitization but not clinical allergy: a randomized, double-blind, placebo-controlled trial in Vietnam. 61 54
19758373 2010
4
Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. 54 61
19796796 2009
5
Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. 54 61
18948425 2009
6
Association of single nucleotide polymorphisms in the eosinophil peroxidase gene with allergic rhinitis in the Czech population. 61 54
19439985 2009
7
Advances in upper airway diseases and allergen immunotherapy in 2007. 54 61
18694591 2008
8
Rhinitis and onset of asthma: a longitudinal population-based study. 54 61
18805333 2008
9
Change in prevalence of atopic dermatitis between 1986 and 2001 among children. 54 61
18702887 2008
10
Paediatric allergy diagnosis in primary care is improved by in vitro allergen-specific IgE testing. 54 61
18312533 2008
11
Recent progress in allergen immunotherapy. 54 61
18319521 2008
12
Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort. 54 61
18037162 2008
13
Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study. 61 54
17822449 2007
14
Anti-IgE in allergic asthma and rhinitis: an update. 54 61
17961096 2007
15
A recombinant humanized anti-IgE monoclonal antibody (omalizumab) in the therapy of moderate-to-severe allergic asthma. 54 61
19075985 2007
16
[Clinical observation on treatment of children's mild continuous asthma by Fangchuan Mixture combined with flixotide]. 54 61
18173144 2007
17
A phase 3 randomized controlled trial of the efficacy and safety of atrasentan in men with metastatic hormone-refractory prostate cancer. 54 61
17886253 2007
18
Systemic and local eosinophil inflammation during the birch pollen season in allergic patients with predominant rhinitis or asthma. 54 61
17967188 2007
19
Allergic asthma and rhinitis caused by household rabbit exposure: identification of serum-specific IgE and its allergens. 54 61
17982229 2007
20
Polymorphisms of histamine-metabolizing enzymes and clinical manifestations of asthma and allergic rhinitis. 61 54
17651147 2007
21
Mediators and cytokines in allergic and viral-triggered rhinitis. 54 61
17883911 2007
22
Up-regulation of protease-activated receptor 2 in allergic rhinitis. 61 54
17727088 2007
23
Cysteinyl-leukotriene levels in sputum differentiate asthma from rhinitis patients with or without bronchial hyperresponsiveness. 61 54
17581201 2007
24
Asthma and rhinitis symptoms in individuals from different socioeconomic levels in a Brazilian city. 61 54
17619568 2007
25
Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. 61 54
17337294 2007
26
What's new in paediatric sleep? 54 61
17419982 2007
27
Inverse relation between nasal fluid Clara Cell Protein 16 levels and symptoms and signs of rhinitis in allergen-challenged patients with intermittent allergic rhinitis. 54 61
17298427 2007
28
Uteroglobin-related protein 1 and clara cell protein in induced sputum of patients with asthma and rhinitis. 61 54
17218572 2007
29
Subjects with non-allergic non-infectious perennial rhinitis do not show nasal hyper-responsiveness to bradykinin. 54 61
17043856 2007
30
Applicability of extracellular electrical impedance tomography in monitoring respiratory tract inflammation. 54 61
17323861 2007
31
Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis. 61 54
17125552 2006
32
The role of allergic rhinitis in nasal responses to sudden temperature changes. 54 61
17088139 2006
33
Management of asthma with anti-immunoglobulin E: a review of clinical trials of omalizumab. 54 61
16949266 2006
34
[Is the seric eosinophil cationic protein level a valuable tool of diagnosis in clinical practice?]. 61 54
16647168 2006
35
Association between angiotensin-converting enzyme gene polymorphism and childhood allergic rhinitis in Taiwan. 61 54
16926975 2006
36
Atopy patch testing in children with asthma and rhinitis symptoms allergic to house dust mite. 54 61
16846452 2006
37
Intercellular adhesion molecule 1 and tumor necrosis factor alpha in asthma and persistent allergic rhinitis: relationship with disease severity. 54 61
16892784 2006
38
Determination of structure and transcriptional regulation of CYSLTR1 and an association study with asthma and rhinitis. 61 54
16771777 2006
39
Low prevalence of the intrinsic form of atopic dermatitis among adult patients. 54 61
16629795 2006
40
Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. 61 54
16433854 2006
41
Lack of association between the IL13 variant Arg110Gln and susceptibility to cedar pollinosis in a Japanese population. 61 54
16272823 2006
42
Sensitization to blackgram in patients with bronchial asthma and rhinitis: clinical evaluation and characterization of allergens. 61 54
16364164 2006
43
[Serum eosinophil cationic protein (ECP) in patients with perennial rhinitis and atopic dermatitis, allergic to house dust mites]. 54 61
16521419 2005
44
Efficacy of intramuscular BCG polysaccharide nucleotide on mild to moderate bronchial asthma accompanied with allergic rhinitis: a randomized, double blind, placebo-controlled study. 61 54
16232343 2005
45
Major lymphocyte populations and T-cell expression of ICAM-1 and L-selectin adhesion molecules in Kuwaitis with asthma and rhinitis. 61 54
17290844 2005
46
Double-blind comparative study of cluster and conventional immunotherapy schedules with Dermatophagoides pteronyssinus. 54 61
15990782 2005
47
Low levels of CC16 in nasal fluid of children with birch pollen-induced rhinitis. 61 54
15813809 2005
48
Immunological characterization of a recombinant tropomyosin from a new indoor source, Lepisma saccharina. 54 61
15836758 2005
49
Aspirin sensitivity: implications for patients with coronary artery disease. 61 54
15613671 2004
50
[Allergic rhinitis and bronchial hyperreactivity]. 54 61
15617661 2004
Sources

Variations for Rhinitis

About this section
Sources

Expression for Rhinitis

About this section
Search GEO for disease gene expression data for Rhinitis.
Sources

Pathways for Rhinitis

About this section

Pathways related to Rhinitis according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.93 VCAM1 RNASE3 POMC IL5 IL4R IL4
2
PEDF Induced Signaling 63
Show member pathways
 13.64 NR3C1 NGF IL5 IL4R IL4 IL13
3
TGF-Beta Pathway 63
Show member pathways
 13.5 NGF IL5 IL4R IL4 IL13 ICAM1
4
Akt Signaling 63
Show member pathways
 13.37 NGF IL5 IL4R IL4 IL13 CXCL8
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.25 VCAM1 POMC IL5 IL4R IL4 IL13
6
PAK Pathway 63
Show member pathways
 13.24 NGF IL5 IL4R IL4 IL13 CXCL8
7
Allograft rejection 1 36
Show member pathways
 12.8 RNASE3 IL5 IL4 IL13 ICAM1 EPX
8
Pathways in cancer 36
12.79 KNG1 IL5 IL4R IL4 IL13 CXCL8
9
Development IGF-1 receptor signaling 22
Show member pathways
 12.33 IL4R IL4 IGHE HRH1 CCL11
10
Immune response CCR3 signaling in eosinophils 22
Show member pathways
 12.29 ICAM1 CXCL8 CCL5 CCL11
11
IL-17 Family Signaling Pathways 64
Show member pathways
 12.27 IL5 IL4 IL13 CXCL8 CCL11
12
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.23 NGF IL5 IL4 IL13 CXCL8
13
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.14 NR3C1 NGF IL13 CXCL8
14
AGE-RAGE signaling pathway in diabetic complications 36
11.84 VCAM1 ICAM1 CXCL8
15
Hematopoietic cell lineage 36
11.83 IL5 IL4R IL4
16
Rheumatoid arthritis 36
11.8 ICAM1 CXCL8 CCL5
17
Innate Lymphoid Cells Differentiation 64
11.73 IL5 IL4 IL13
18
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.71 IL5 IL4 CXCL8
19
IL4-mediated signaling events 1
11.63 IL5 IL4R IL4 IGHE CCL11
20
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.6 VCAM1 NR3C1 ICAM1 CXCL8
21
Malaria 36
11.51 VCAM1 ICAM1 CXCL8
22
Interleukin-10 signaling 65
11.46 IL4 IL13 ICAM1 CXCL8 CCL5
23
Immune response_Role of integrins in NK cells cytotoxicity 22
11.45 VCAM1 ICAM1 CXCL8
24
Lung fibrosis 1
11.43 IL5 IL4 IL13 CXCL8 CCL5 CCL11
25
Glucocorticoid receptor regulatory network 1
11.41 POMC NR3C1 IL5 IL4 IL13 ICAM1
26
Th2 Differentiation 64
11.38 IL5 IL4R IL4 IL13 CCL11
27
African trypanosomiasis 36
11.36 VCAM1 KNG1 ICAM1
28
Interleukin-4 and 13 signaling 65
11.33 VCAM1 POMC IL4R IL4 IL13 IGHE
29
Inflammatory Response Pathway 1
11.29 IL5 IL4R IL4
30
Development and heterogeneity of the ILC family 1
11.27 IL5 IL4 IL13
31
Cytokines and Inflammatory Response 1
11.21 IL5 IL4 IL13
32
OX40 Pathway 63
11.15 IL5 IL4 IL13
33
IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.92 VCAM1 IL4R IL4
34
G-protein signaling_Rap2B regulation pathway 22
10.92 NGF IL5 IL4 IL13 CXCL8 CCL5
35
IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types 64
10.64 IL5 IL4R IL4 IL13
Sources

GO Terms for Rhinitis

About this section

Cellular components related to Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 RNASE3 POMC NGF KNG1 IL5 IL4R
2 extracellular space GO:0005615 9.47 VCAM1 RNASE3 POMC NGF KNG1 IL5

Biological processes related to Rhinitis according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.11 POMC KNG1 HRH1 CYSLTR1 CXCL8 CCL5
2 signal transduction GO:0007165 10.07 POMC NR3C1 IL5 IL4R IL4 HRH1
3 chemotaxis GO:0006935 9.84 CYSLTR1 CXCL8 CCL5 CCL11
4 cellular response to interferon-gamma GO:0071346 9.8 ICAM1 CCL5 CCL11
5 positive regulation of cold-induced thermogenesis GO:0120162 9.8 IL4R IL4 IL13
6 cellular response to tumor necrosis factor GO:0071356 9.8 ICAM1 CXCL8 CCL5 CCL11
7 neutrophil chemotaxis GO:0030593 9.77 CXCL8 CCL5 CCL11
8 chemokine-mediated signaling pathway GO:0070098 9.76 CXCL8 CCL5 CCL11
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.75 IL4 IL13 CCL5
10 positive regulation of T cell proliferation GO:0042102 9.73 VCAM1 IL4 CCL5
11 inflammatory response GO:0006954 9.7 KNG1 IL5 IL13 HRH1 CXCL8 CCL5
12 positive regulation of B cell proliferation GO:0030890 9.69 IL5 IL4 IL13
13 negative regulation of endothelial cell apoptotic process GO:2000352 9.65 IL4 IL13 ICAM1
14 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.62 CXCL8 CCL5
15 cellular response to interleukin-1 GO:0071347 9.62 ICAM1 CXCL8 CCL5 CCL11
16 macrophage activation GO:0042116 9.61 IL4 IL13
17 neutrophil activation GO:0042119 9.61 CXCL8 CCL5
18 leukocyte cell-cell adhesion GO:0007159 9.61 VCAM1 ICAM1 CCL5
19 positive regulation of interleukin-10 secretion GO:2001181 9.6 IL4 IL13
20 eosinophil chemotaxis GO:0048245 9.58 HRH1 CCL5 CCL11
21 immune response GO:0006955 9.56 IL5 IL4R IL4 IL13 IGHE CXCL8
22 positive regulation of immunoglobulin production GO:0002639 9.55 IL4R IL13
23 membrane to membrane docking GO:0022614 9.52 VCAM1 ICAM1
24 negative regulation of complement-dependent cytotoxicity GO:1903660 9.46 IL4 IL13
25 positive regulation of mast cell degranulation GO:0043306 9.43 IL4R IL4 IL13
26 cytokine-mediated signaling pathway GO:0019221 9.36 VCAM1 POMC IL5 IL4R IL4 IL13

Molecular functions related to Rhinitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.13 CXCL8 CCL5 CCL11
2 cytokine activity GO:0005125 9.1 IL5 IL4 IL13 CXCL8 CCL5 CCL11
Sources

Sources for Rhinitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....