MCID: RHN002
MIFTS: 37

Rhinoscleroma

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Rhinoscleroma

MalaCards integrated aliases for Rhinoscleroma:

Name: Rhinoscleroma 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11336
ICD9CM 35 040.1
MeSH 44 D012226
SNOMED-CT 68 72409005
UMLS 73 C0035468

Summaries for Rhinoscleroma

Disease Ontology : 12 A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

MalaCards based summary : Rhinoscleroma is related to rhinosporidiosis and chronic rhinitis. An important gene associated with Rhinoscleroma is RHNO1 (RAD9-HUS1-RAD1 Interacting Nuclear Orphan 1), and among its related pathways/superpathways are NF-kappaB Signaling and Lung fibrosis. The drugs Gemifloxacin and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include trachea, testes and skin, and related phenotype is neoplasm.

Wikipedia : 76 Rhinoscleroma, or simply scleroma, is a chronic granulomatous bacterial disease of the nose that can... more...

Related Diseases for Rhinoscleroma

Diseases related to Rhinoscleroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 rhinosporidiosis 29.6 CD68 DCXR NCAM1 RHNO1 SERPINA1
2 chronic rhinitis 11.4
3 rosai-dorfman disease 10.2
4 mastoiditis 10.2 RHNO1 SLC29A3
5 frontal sinusitis 10.2 DCXR RHNO1
6 ethmoid sinusitis 10.2 DCXR RHNO1
7 rhinitis 10.1
8 selective igg deficiency disease 10.1 CD19 NCAM1
9 plasma protein metabolism disease 10.1 CD19 SERPINA1
10 cd3zeta deficiency 10.1 CCR2 NCAM1
11 rectum squamous cell carcinoma 10.1 DCXR TNFRSF1B
12 solitary osseous plasmacytoma 10.1 CD19 NCAM1
13 plasma cell neoplasm 10.0 CD19 NCAM1
14 monoclonal gammopathy of uncertain significance 10.0 CD19 NCAM1
15 cystadenofibroma 10.0 NCAM1 SERPINA1
16 lung lymphoma 10.0 CD19 NCAM1
17 orbital plasma cell granuloma 10.0 NCAM1 TNFRSF1B
18 panniculitis 10.0 NCAM1 SERPINA1
19 chronic orbital inflammation 10.0 NCAM1 TNFRSF1B
20 transient arthritis 10.0 SERPINA1 TNFRSF1B
21 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
22 papilloma 10.0
23 inverted papilloma 10.0
24 erdheim-chester disease 10.0
25 atrophic rhinitis 10.0
26 exophthalmos 10.0
27 lipogranulomatosis 10.0
28 mature b-cell neoplasm 10.0 CD19 NCAM1
29 phacolytic glaucoma 10.0 CD68 SERPINA1
30 adult xanthogranuloma 9.9 CD68 SERPINA1
31 inflammatory mfh 9.9 CD68 SERPINA1
32 cogan syndrome 9.9 SERPINA1 TNFRSF1B
33 leukocyte disease 9.9 CD19 NCAM1
34 lymphatic system cancer 9.9 CD19 NCAM1 SPN
35 erythema elevatum diutinum 9.9 CD68 TNFRSF1B
36 anterior scleritis 9.9 CD19 NCAM1 TNFRSF1B
37 acute salpingitis 9.8 CD68 TNFRSF1B
38 lymphoma, mucosa-associated lymphoid type 9.8 CD19 SPN
39 melkersson-rosenthal syndrome 9.8 CD68 TNFRSF1B
40 reticulohistiocytic granuloma 9.8 CD68 SERPINA1 SPN
41 aleukemic leukemia cutis 9.7 CD68 NCAM1 SPN
42 granulomatous myositis 9.7 CD68 NCAM1 TNFRSF1B
43 pericoronitis 9.6 CD19 CD68 NCAM1 TNFRSF1B
44 parasitic ichthyosporea infectious disease 9.5 CD68 DCXR NCAM1 RHNO1 SERPINA1

Comorbidity relations with Rhinoscleroma via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Rhinoscleroma:



Diseases related to Rhinoscleroma

Symptoms & Phenotypes for Rhinoscleroma

MGI Mouse Phenotypes related to Rhinoscleroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CCR2 CD19 SLC29A3 SPN TNFRSF1B

Drugs & Therapeutics for Rhinoscleroma

Drugs for Rhinoscleroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Gemifloxacin Approved, Investigational Early Phase 1 175463-14-6 5464436 9571107
2
Ciprofloxacin Approved, Investigational Early Phase 1 85721-33-1 2764
3
Rifampicin Approved Early Phase 1 13292-46-1 5458213 5381226
4 Cytochrome P-450 Enzyme Inhibitors Early Phase 1
5 Anti-Infective Agents Early Phase 1
6 Antibiotics, Antitubercular Early Phase 1
7 Topoisomerase Inhibitors Early Phase 1
8 Fluoroquinolones Early Phase 1
9 Cytochrome P-450 CYP3A Inducers Early Phase 1
10 Antitubercular Agents Early Phase 1
11 Cytochrome P-450 CYP1A2 Inhibitors Early Phase 1
12 Nucleic Acid Synthesis Inhibitors Early Phase 1
13 Anti-Bacterial Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Interventional Cryotherapy for the Eradication of Benign Airway Disease ("ICE the BAD") Terminated NCT00747461 Phase 4
2 Comparison Between Rifampicin and Gemifloxacin and Ciprofloxacin in Treatment of Rhinoscleroma Not yet recruiting NCT03326050 Early Phase 1 Gemifloxacin;Ciprofloxacin;Rifampicin

Search NIH Clinical Center for Rhinoscleroma

Cochrane evidence based reviews: rhinoscleroma

Genetic Tests for Rhinoscleroma

Anatomical Context for Rhinoscleroma

MalaCards organs/tissues related to Rhinoscleroma:

41
Trachea, Testes, Skin, Lymph Node, Bone, Lung, B Cells

Publications for Rhinoscleroma

Articles related to Rhinoscleroma:

(show top 50) (show all 214)
# Title Authors Year
1
Rhinoscleroma pathogenesis: The type K3 capsule of Klebsiella rhinoscleromatis is a virulence factor not involved in Mikulicz cells formation. ( 29381692 )
2018
2
Social geography of Rhinoscleroma and qualitatively and quantitatively abnormal cell-mediated immunity. ( 29578083 )
2018
3
Rhinoscleroma: An Unusual Presentation. ( 29854642 )
2018
4
Rhinoscleroma. ( 30168726 )
2018
5
Rhinoscleroma: Report of an Erratic Palatal Swelling. ( 30294174 )
2018
6
Long-term follow-up of repair of external nasal deformities in rhinoscleroma patients. ( 30322780 )
2018
7
Role of Histopathology in Differentiating Primary Atrophic Rhinitis from Atrophic Stage of Rhinoscleroma. ( 28239581 )
2017
8
Rhinoscleroma: a chronic infectious disease of poor areas with characteristic histological features - report of a series of six cases. ( 28420289 )
2017
9
Rhinoscleroma with intracranial extension: A rare case. ( 27147167 )
2016
10
Tracheal rhinoscleroma. ( 26769262 )
2016
11
Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae. ( 27293924 )
2016
12
A case of laryngeal rhinoscleroma. ( 26778445 )
2016
13
Rhinoscleroma: a detailed histopathological diagnostic insight. ( 26339415 )
2015
14
Laryngeal involvement of rhinoscleroma. ( 26340893 )
2015
15
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. ( 29021044 )
2015
16
Images in Clinical Medicine. Rhinoscleroma. ( 26083225 )
2015
17
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. ( 26163236 )
2015
18
Rhinoscleroma of nose extruding into oral cavity. ( 25933455 )
2015
19
Rhinoscleroma in a 5-year-old Portuguese Child. ( 24445824 )
2014
20
Emperipolesis is not pathognomonic for Rosai-Dorfman disease: rhinoscleroma mimicking Rosai-Dorfman disease, a clinical series. ( 24238175 )
2013
21
Rhinoscleroma: a case series report and review of the literature. ( 23904142 )
2013
22
Rhinoscleroma presenting as a nasal-palatal mass with airway obstruction. ( 24358881 )
2013
23
A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes. ( 23554169 )
2013
24
Coexistence of rhinoscleroma with Rosai-Dorfman disease: is rhinoscleroma a cause of this disease? ( 22643208 )
2012
25
Rhinoscleroma in an immigrant from Egypt: a case report. ( 23379711 )
2012
26
Rhinoscleroma: a case series. ( 22337196 )
2012
27
Rhinoscleroma with involvement of the maxillary sinus, orbital floor, and temporomandibular joint: a case report. ( 21549476 )
2012
28
Rhinoscleroma in an urban nonendemic setting. ( 22166959 )
2012
29
Cytohistological features of rhinoscleroma. ( 22234117 )
2011
30
Pathology quiz case 1. Rhinoscleroma. ( 22006786 )
2011
31
Rhinoscleroma: a retrospective study of pathologic and clinical features. ( 21453653 )
2011
32
Rhinoscleroma: an updated experience through the last 10 years. ( 21198342 )
2011
33
PCR-based identification of Klebsiella pneumoniae subsp. rhinoscleromatis, the agent of rhinoscleroma. ( 21629720 )
2011
34
Airway management of an unusual case of recurrent rhinoscleroma. ( 21897516 )
2011
35
B lymphocyte subsets in patients with rhinoscleroma. ( 21493362 )
2011
36
Retrospective study of the rhinoscleroma about 14 cases in ENT departments of university hospitals (CA'te d'Ivoire). ( 21256101 )
2011
37
Rhinoscleroma: case report. ( 20015775 )
2010
38
Septal rhinoscleroma. ( 21217987 )
2010
39
Rhinoscleroma: a case report. ( 21225500 )
2010
40
Rhinoscleroma causing severe bilateral nasal obstruction. ( 20563449 )
2010
41
Tracheobronchial rhinoscleroma. ( 23168595 )
2009
42
Bilateral nasal vestibular stenosis: a case of rhinoscleroma and review of surgical techniques. ( 23120507 )
2008
43
Rhinoscleroma in a young adult with chronic rhinitis and dyspnea. ( 18816882 )
2008
44
Rhinoscleroma: a French national retrospective study of epidemiological and clinical features. ( 18947330 )
2008
45
Rhinoscleroma of the sinuses. ( 19146007 )
2008
46
Radiology quiz case 2. Rhinoscleroma and cervical emphysema. ( 17576916 )
2007
47
Test and teach. Number 39. Diagnosis: Rhinoscleroma. ( 17886103 )
2007
48
Rhinoscleroma: a clinicopathological study from the Gulf region. ( 17304395 )
2007
49
Rhinoscleroma: case report. ( 17143439 )
2006
50
Simultaneous occurrence of nasal and cervical rhinoscleroma. ( 16930003 )
2006

Variations for Rhinoscleroma

Expression for Rhinoscleroma

Search GEO for disease gene expression data for Rhinoscleroma.

Pathways for Rhinoscleroma

Pathways related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 CCR2 CD19 NCAM1 TNFRSF1B
2 11.17 CCR2 SERPINA1
3 11.05 CD19 SPN
4 11 CD19 NCAM1 SPN
5 10.99 CD19 CD68 NCAM1 SPN
6 10.95 CCR2 TNFRSF1B

GO Terms for Rhinoscleroma

Cellular components related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.13 CCR2 CD19 NCAM1
2 microvillus GO:0005902 8.62 DCXR SPN

Biological processes related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8.96 CCR2 SPN
2 cellular defense response GO:0006968 8.8 CCR2 CD19 SPN

Sources for Rhinoscleroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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