MCID: RHN002
MIFTS: 36

Rhinoscleroma

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Rhinoscleroma

MalaCards integrated aliases for Rhinoscleroma:

Name: Rhinoscleroma 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:11336
ICD9CM 34 040.1
MeSH 44 D012226
SNOMED-CT 67 72409005
UMLS 70 C0035468

Summaries for Rhinoscleroma

Disease Ontology : 12 A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis.

MalaCards based summary : Rhinoscleroma is related to histiocytosis and leprosy 3. An important gene associated with Rhinoscleroma is SLC29A3 (Solute Carrier Family 29 Member 3), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Tight junction. The drugs Ciprofloxacin and Gemifloxacin have been mentioned in the context of this disorder. Affiliated tissues include trachea, skin and lymph node.

Wikipedia : 73 Rhinoscleroma, is a chronic granulomatous bacterial disease of the nose that can sometimes infect the... more...

Related Diseases for Rhinoscleroma

Diseases related to Rhinoscleroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 29.3 SLC29A3 CD1C CD1A
2 leprosy 3 28.5 CD68 CD1E CD1D CD1C CD1B CD1A
3 erdheim-chester disease 28.2 CD1E CD1D CD1C CD1B CD1A
4 exophthalmos 28.2 CD68 CD1E CD1D CD1C CD1B CD1A
5 histiocytosis-lymphadenopathy plus syndrome 27.6 SLC29A3 CD68 CD1E CD1D CD1C CD1B
6 chronic rhinitis 11.0
7 chronic granulomatous disease 10.4
8 disease by infectious agent 10.2
9 rhinitis 10.2
10 hansen's disease 10.2
11 rosai-dorfman disease 10.2
12 syphilis 10.1
13 atrophic rhinitis 10.1
14 rhinosporidiosis 10.1
15 granulomatous orchitis 10.0 CD68 CD1E
16 predominantly cortical thymoma 10.0 CD1E CD1A
17 tolosa-hunt syndrome 10.0 CD1E CD1A
18 multicentric reticulohistiocytosis 10.0 CD68 CD1E
19 paracoccidioidomycosis 10.0
20 sarcoidosis 1 10.0
21 dendritic cell thymoma 10.0 CD1E CD1A
22 multifocal motor neuropathy 9.9 CD1E CD1A
23 oral hairy leukoplakia 9.9 CD1E CD1A
24 pityriasis rosea 9.9 CD1E CD1A
25 kimura disease 9.9 CD1E CD1A
26 dendritic cell tumor 9.8 CD68 CD1A
27 tracheal stenosis 9.8
28 inverted papilloma 9.8
29 papilloma 9.8
30 basal cell carcinoma 9.8
31 enthesopathy 9.8
32 squamous cell papilloma 9.8
33 mikulicz disease 9.8
34 neutropenia 9.8
35 allergic disease 9.8
36 lepromatous leprosy 9.8
37 tuberculoid leprosy 9.8
38 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.8
39 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
40 kala-azar 1 9.8
41 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
42 leishmaniasis 9.8
43 amyloidosis 9.8
44 asrar facharzt haque syndrome 9.8
45 malakoplakia 9.8
46 anoxia 9.8
47 dysphagia 9.8
48 headache 9.8
49 mite infestation 9.8 CD1B CD1A
50 skin sarcoidosis 9.7 CD1C CD1B

Comorbidity relations with Rhinoscleroma via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Rhinoscleroma:



Diseases related to Rhinoscleroma

Symptoms & Phenotypes for Rhinoscleroma

Drugs & Therapeutics for Rhinoscleroma

Drugs for Rhinoscleroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Early Phase 1 85721-33-1 2764
2
Gemifloxacin Approved, Investigational Early Phase 1 175463-14-6 9571107 5464436
3
Rifampicin Approved Early Phase 1 13292-46-1 5381226 5458213
4 Antibiotics, Antitubercular Early Phase 1
5 Cytochrome P-450 Enzyme Inhibitors Early Phase 1
6 Anti-Bacterial Agents Early Phase 1
7 Anti-Infective Agents Early Phase 1
8 Antitubercular Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment of the Safety, Side Effects and Efficacy of Interventional Cryotherapy for the Eradication of Benign Airway Disease("ICE THE BAD") Terminated NCT00747461 Phase 4
2 Gemifloxacin Versus Ciprofloxacin Versus Rifampicin in Treatment of Rhinoscleroma Unknown status NCT03326050 Early Phase 1 Gemifloxacin;Ciprofloxacin;Rifampicin

Search NIH Clinical Center for Rhinoscleroma

Cochrane evidence based reviews: rhinoscleroma

Genetic Tests for Rhinoscleroma

Anatomical Context for Rhinoscleroma

MalaCards organs/tissues related to Rhinoscleroma:

40
Trachea, Skin, Lymph Node, Bone, Monocytes

Publications for Rhinoscleroma

Articles related to Rhinoscleroma:

(show top 50) (show all 394)
# Title Authors PMID Year
1
Peripheral Cardiopulmonary Bypass in Two Patients With Symptomatic Tracheal Masses: Perioperative Challenges. 61
33339662 2021
2
Algorithmic Approach to Fibroinflammatory Sinonasal Tract Lesions. 61
33723762 2021
3
Topical ciprofloxacin as treatment for rhinoscleroma in a series of 23 patients. 61
33650263 2021
4
Rebellious headache revealing an extensive rhinoscleroma: A case report and review of the literature. 61
33643651 2021
5
Extranodal natural killer/T cell lymphoma with involvement of the bilateral submandibular lymph node mimicking a rhinoscleroma: a diagnostic challenge. 61
32446996 2021
6
[Tracheal rhinoscleroma]. 61
32278063 2020
7
Correlation Between Nasal and Laryngeal Lesions of Rhinoscleroma in Patients of Upper Egypt. 61
32826120 2020
8
Changes in the pattern of rhinoscleroma in Egypt: updated experience. 61
31533871 2019
9
[Rhinoscleroma misdiagnosed as a septal cyst:a case report]. 61
31163536 2019
10
Report of a case of giant rhinoscleroma: CT and MRI. 61
30931141 2018
11
Rhinoscleroma. 61
30168726 2018
12
Long-term follow-up of repair of external nasal deformities in rhinoscleroma patients. 61
30322780 2018
13
Rhinoscleroma: Report of an Erratic Palatal Swelling. 61
30294174 2018
14
Social geography of Rhinoscleroma and qualitatively and quantitatively abnormal cell-mediated immunity. 61
29578083 2018
15
Rhinoscleroma: An Unusual Presentation. 61
29854642 2018
16
[Rhinoscleroma of the cavum with expression in cervical lymph nodes: about a case]. 61
30364372 2018
17
[Rhinoscleroma: a rare chronic infection of the nasal cavities]. 61
31448004 2018
18
Rhinoscleroma pathogenesis: The type K3 capsule of Klebsiella rhinoscleromatis is a virulence factor not involved in Mikulicz cells formation. 61
29381692 2018
19
Rhinoscleroma: a chronic infectious disease of poor areas with characteristic histological features - report of a series of six cases. 61
28420289 2018
20
Granulomatous & histiocytic dermatitides. 61
28094163 2017
21
Role of Histopathology in Differentiating Primary Atrophic Rhinitis from Atrophic Stage of Rhinoscleroma. 61
28239581 2017
22
[Rhinoscleroma affects the nasal cavity and sinuses:a report of 2 cases and literature review]. 61
29871166 2016
23
A case of lobar pneumonia and sepsis with death caused by invasive Klebsiella rhinoscleromatis infection. 61
27184935 2016
24
Laryngeal involvement of rhinoscleroma. 61
26340893 2016
25
A case of laryngeal rhinoscleroma. 61
26778445 2016
26
Rhinoscleroma with intracranial extension: A rare case. 61
27147167 2016
27
Tracheal rhinoscleroma. 61
26769262 2016
28
Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae. 61
27293924 2016
29
[Rhinoscleroma disease accompanied with laryngotracheal stenosis: a case report]. 61
26930922 2015
30
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. 61
29021044 2015
31
Topical mitomycin C as an adjunct to surgical debulking and medical treatment in rhinoscleroma. 61
26163236 2015
32
Images in Clinical Medicine. Rhinoscleroma. 61
26083225 2015
33
Rhinoscleroma of nose extruding into oral cavity. 61
25933455 2015
34
Rhinoscleroma: a detailed histopathological diagnostic insight. 61
26339415 2015
35
The involvement of upper airway in Wegener's granulomatosis - about four cases. 61
26193239 2015
36
Unexpected pathologies in patients referred for endoscopic DCR. 61
24477341 2014
37
Granulomatous disease in the head and neck: developing a differential diagnosis. 61
25208278 2014
38
Rhinoscleroma in a 5-year-old Portuguese Child. 61
24445824 2014
39
Rhinoscleroma: a case series report and review of the literature. 61
23904142 2014
40
Emperipolesis is not pathognomonic for Rosai-Dorfman disease: rhinoscleroma mimicking Rosai-Dorfman disease, a clinical series. 61
24238175 2013
41
[Giant rhinoscleroma]. 61
23827273 2013
42
[Expression and significance of IgG4 in inflammatory disease of nasal cavity and paranasal sinuses]. 61
24060072 2013
43
A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes. 61
23554169 2013
44
Rhinoscleroma presenting as a nasal-palatal mass with airway obstruction. 61
24358881 2013
45
Rhinoscleroma in an immigrant from Egypt: a case report. 61
23379711 2012
46
[One case report of Rosai-Dorfman disease in nasal cavity and nasal sinuses]. 61
23373249 2012
47
[Rhinoscleroma: two cases in Bobo-Dioulasso in Burkina Faso]. 61
23361106 2012
48
Histopathological study of lesions of nose and paranasal sinuses. 61
23998035 2012
49
Rhinoscleroma in an urban nonendemic setting. 61
22166959 2012
50
Coexistence of rhinoscleroma with Rosai-Dorfman disease: is rhinoscleroma a cause of this disease? 61
22643208 2012

Variations for Rhinoscleroma

Expression for Rhinoscleroma

Search GEO for disease gene expression data for Rhinoscleroma.

Pathways for Rhinoscleroma

GO Terms for Rhinoscleroma

Cellular components related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.02 SLC29A3 CD68 CD1E CD1D CD1C CD1B
2 plasma membrane GO:0005886 9.93 SLC29A3 CD68 CD1D CD1C CD1B CD1A
3 integral component of membrane GO:0016021 9.91 SLC29A3 CD68 CD1E CD1D CD1C CD1B
4 extracellular space GO:0005615 9.8 CD1E CD1D CD1C CD1B CD1A
5 integral component of plasma membrane GO:0005887 9.73 CD1E CD1D CD1C CD1A
6 external side of plasma membrane GO:0009897 9.65 CD1E CD1D CD1C CD1B CD1A
7 lysosomal membrane GO:0005765 9.62 SLC29A3 CD68 CD1D CD1B
8 endosome membrane GO:0010008 9.55 CD68 CD1D CD1C CD1B CD1A
9 lysosome GO:0005764 9.43 SLC29A3 CD68 CD1E CD1D CD1C CD1B
10 endosome GO:0005768 9.17 SLC29A3 CD68 CD1E CD1D CD1C CD1B

Biological processes related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 CD1E CD1D CD1C CD1B CD1A
2 adaptive immune response GO:0002250 9.71 CD1E CD1C CD1B CD1A
3 immune response GO:0006955 9.65 CD1E CD1D CD1C CD1B CD1A
4 regulation of immune response GO:0050776 9.62 CD1D CD1C CD1B CD1A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
6 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
7 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Rhinoscleroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Rhinoscleroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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