MCID: RHN003
MIFTS: 37

Rhinosporidiosis

Categories: Infectious diseases

Aliases & Classifications for Rhinosporidiosis

MalaCards integrated aliases for Rhinosporidiosis:

Name: Rhinosporidiosis 12 44 15 17 70 32
Infection by Rhinosporidium Seeberi 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2409
ICD9CM 34 117.0
MeSH 44 D012227
SNOMED-CT 67 18140003
ICD10 32 B48.1
UMLS 70 C0035469

Summaries for Rhinosporidiosis

Disease Ontology : 12 A parasitic Ichthyosporea infectious disease that is a chronic granulomatous infection of the mucous membranes caused by the parasite Rhinosporidium seeberi, which manifests as vascular friable polyps that arise from the nasal mucosa or external structures of the eye. Disease of the skin, mouth, upper airways, ear, genitals, and rectum has also been observed.

MalaCards based summary : Rhinosporidiosis, also known as infection by rhinosporidium seeberi, is related to leprosy 3 and disease by infectious agent. An important gene associated with Rhinosporidiosis is TIA1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include eye, trachea and skin, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 Rhinosporidiosis is an infection caused by Rhinosporidium... more...

Related Diseases for Rhinosporidiosis

Diseases related to Rhinosporidiosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 229)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 30.3 IL4 CD8A CD68 CD4
2 disease by infectious agent 30.2 SERPINA1 IL4 CD8A CD4
3 fungal infectious disease 30.0 IL4 CLEC7A CD8A CD4
4 cryptococcosis 29.6 IL4 CLEC7A CD8A CD4
5 actinomycosis 29.4 IL4 FN1 CD68 CD4
6 immune deficiency disease 28.9 IL4 FN1 DNASE1 CD8A CD4
7 chronic rhinitis 10.9
8 chronic granulomatous disease 10.5
9 orbit lymphoma 10.4 TIA1 NCAM1
10 systemic epstein-barr virus-positive t-cell lymphoma of childhood 10.4 TIA1 NCAM1
11 bacterial esophagitis 10.4 CD68 CD4
12 xanthogranulomatous pyelonephritis 10.4 CD68 AOAH
13 cork-handlers' disease 10.4 CD8A CD4
14 necrotic uveal melanoma 10.4 CD8A CD4
15 lichen sclerosus et atrophicus 10.4 TIA1 CD8A
16 lethal midline granuloma 10.4 TIA1 NCAM1
17 granulomatous myositis 10.4 CD8A CD68
18 early yaws 10.4 CD8A CD4
19 ventilation pneumonitis 10.4 CD8A CD4
20 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
21 latent syphilis 10.4 CD8A CD4
22 lymphocytic gastritis 10.4 TIA1 CD8A
23 orbital cellulitis 10.4 NCAM1 CD4
24 type 1 diabetes mellitus 23 10.4 CD8A CD4
25 acute orbital inflammation 10.4 NCAM1 CD4
26 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
27 lymphohistiocytoid mesothelioma 10.4 CD8A CD68
28 parapsoriasis 10.4 CD8A CD4
29 gastroduodenitis 10.4 CD8A CD4
30 geniculate ganglionitis 10.4 IFNA2 CD4
31 primary syphilis 10.4 CD8A CD4
32 lymphomatoid granulomatosis 10.4 TIA1 IFNA2
33 norwegian scabies 10.4 CD8A CD4
34 bird fancier's lung 10.4 CD8A CD4
35 conjunctival pigmentation 10.4 IFNA2 CD68
36 skin sarcoidosis 10.3 CD8A CD4
37 nasal cavity lymphoma 10.3 TIA1 NCAM1
38 variola major 10.3 CD8A CD4
39 granuloma annulare 10.3 CD68 CD4
40 tertiary syphilis 10.3 CD8A CD4
41 spongiotic dermatitis 10.3 CD8A CD4
42 acute retinal necrosis syndrome 10.3 CD8A CD4
43 congenital granular cell tumor 10.3 SERPINA1 CD68
44 maxillary sinus inverted papilloma 10.3 DNASE1 CD8A
45 liver sarcoma 10.3 SERPINA1 CD68
46 gastrointestinal lymphoma 10.3 TIA1 NCAM1
47 cerebral lymphoma 10.3 CD8A CD4
48 oral tuberculosis 10.3 CD8A CD4
49 cerebritis 10.3 CD8A CD4
50 invasive malignant thymoma 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Rhinosporidiosis:



Diseases related to Rhinosporidiosis

Symptoms & Phenotypes for Rhinosporidiosis

GenomeRNAi Phenotypes related to Rhinosporidiosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.53 NCAM1
2 Decreased viability GR00240-S-1 9.53 TIA1
3 Decreased viability GR00249-S 9.53 IFNA21 TIA1
4 Decreased viability GR00342-S-2 9.53 CD4
5 Decreased viability GR00381-A-1 9.53 APOF CLEC7A TIA1
6 Decreased viability GR00381-A-2 9.53 CLEC7A
7 Decreased viability GR00381-A-3 9.53 APOF
8 Decreased viability GR00386-A-1 9.53 IFNA17 VGF
9 Decreased viability GR00402-S-2 9.53 APOF BMP2 CD8A IFNA21

MGI Mouse Phenotypes related to Rhinosporidiosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 AOAH BMP2 CD4 CD68 CD8A CLEC7A

Drugs & Therapeutics for Rhinosporidiosis

Search Clinical Trials , NIH Clinical Center for Rhinosporidiosis

Cochrane evidence based reviews: rhinosporidiosis

Genetic Tests for Rhinosporidiosis

Anatomical Context for Rhinosporidiosis

MalaCards organs/tissues related to Rhinosporidiosis:

40
Eye, Trachea, Skin, Bone, Tongue

Publications for Rhinosporidiosis

Articles related to Rhinosporidiosis:

(show top 50) (show all 548)
# Title Authors PMID Year
1
Nasal Rhinosporidiosis: Clinical Presentation, Clinical Findings, and Outcome in Dogs. 61
33770179 2021
2
Disseminated cutaneous rhinosporidiosis. 61
33666062 2021
3
Rhinosporidium seeberi: Is It a Fungi or Parasite? 61
33269573 2020
4
Case Report: Rhinosporidiosis, Case Report, and Literature Review. 61
33289469 2020
5
[Canine nasal rhinosporidiosis in Argentina]. 61
33168230 2020
6
Disseminated cutaneous rhinosporidiosis. 61
33106452 2020
7
Tracheobronchial rhinosporidiosis: an uncommon life-threatening benign cause of airway obstruction. 61
32874589 2020
8
18F-FDG PET/MRI of Rhinosporidiosis of the Upper Airways. 61
32657860 2020
9
Recurrent Disseminated Cutaneous Rhinosporidiosis - Where is the End? 61
32831384 2020
10
An Unexpected Host in a Soft-Tissue Lesion of Thigh. 61
33589209 2020
11
Rhinosporidiosis in Central India: A cross-sectional study from a tertiary care hospital in Chhattisgarh. 61
33747879 2020
12
Ocular rhinosporidiosis. 61
31608924 2020
13
An unexpected host in a soft-tissue lesion of thigh. 61
33154269 2020
14
Pharyngeal rhinosporidiosis. 61
32554456 2020
15
Isolated Primary Rhinosporidiosis of the Parotid Duct: A Rare Presentation. 61
32596180 2020
16
Disseminated Cutaneous Rhinosporidiosis: Revisited. 61
32565561 2020
17
Laryngeal rhinosporidiosis: An airway catastrophe averted. 61
32318507 2020
18
Calvarial involvement in disseminated rhinosporidiosis - A case report and literature review. 61
31898592 2020
19
Strawberry nose and rhinosporidiosis. 61
31147710 2020
20
Recurrent nasopharyngeal rhinosporidiosis: Case report from Qatar and review of the literature. 61
32685372 2020
21
Evaluation of diagnosed cases of eye rhinosporidiosis in a public hospital of Maranhão, Northeast Brazil. 61
31703563 2019
22
Diagnostic Evaluation of Chronic Nasal Obstruction Based on Nasal Endoscopy and CT Scan Paranasal Sinus. 61
31763274 2019
23
Series of Atypical Rhinosporidiosis: Our Experience in Western Part of West Bengal. 61
31763261 2019
24
Cluster of Nasal Rhinosporidiosis, Eastern Province, Rwanda. 61
31441764 2019
25
Maxillary rehabilitation after complete destruction by fungal osteomyelitis. 61
31854379 2019
26
Lacrimal sac rhinosporidiosis: case report and review of literature with a new grading system to optimize treatment. 61
31686971 2019
27
Rhinosporidiosis of the Lacrimal Sac. 61
30865068 2019
28
External dacryocystorhinostomy for isolated lacrimal sac rhinosporidiosis - A suitable alternative to dacryocystectomy. 61
31007236 2019
29
Rhinosporidiosis. 61
30943339 2019
30
Next-generation sequencing for hypothesis-free genomic detection of invasive tropical infections in poly-microbially contaminated, formalin-fixed, paraffin-embedded tissue samples - a proof-of-principle assessment. 61
30961537 2019
31
Cutaneous Rhinosporidiosis Presenting as Cutaneous Horn and Verrucous Plaque. 61
30984597 2019
32
Pharyngeal Rhinosporidiosis. 61
30843506 2019
33
[First case of ocular rhinosporidiosis in French Guiana]. 61
30119961 2019
34
Three unusual cases of parasites in eye. 61
30706886 2019
35
Lacrimal Sac Rhinosporidiosis and Surgical Management by Transnasal Endoscopic Excision: A Case Series. 61
30194840 2018
36
Palatal rhinosporidiosis: an unusual case report and review of the literature. 61
30637244 2018
37
Long-term use of Le Fort I osteotomy for the management of nasopharyngeal rhinosporidiosis: A case series. 61
30481854 2018
38
Rhinosporidiosis in Colombia: case series and literature review. 61
30033826 2018
39
Polymorphic presentation of disseminated cutaneous rhinosporidiosis in an immunocompetent individual. 61
30073987 2018
40
Nondisseminated rhinosporidiosis with multisite involvement in the head and neck. 61
30273436 2018
41
Nasopharyngeal rhinosporidiosis with intracranial extension masquerading as juvenile angiofibroma: an unusual entity. 61
29745260 2018
42
Partial regression of large anterior scleral staphyloma secondary to rhinosporidiosis after corneoscleral graft - a case report. 61
29486755 2018
43
Magnetic Resonance Imaging in Evaluation of Sinonasal Masses with Histopathological Correlation. 61
29459588 2018
44
Disseminated Cutaneous Rhinosporidiosis. 61
29551119 2018
45
Conjunctival Rhinosporidiosis with Lateral Rectus Muscle Involvement. 61
29403599 2018
46
A Rare Presentation of Rhinosporidiosis. 61
29238691 2017
47
Rhinosporidiosis. 61
28757369 2017
48
Rare case of disseminated rhinosporidiosis with chronic osteomyelitis of the calcaneum treated by a simple technique of negative pressure wound therapy. 61
29038194 2017
49
Penile rhinosporidiosis: An unusual presentation and review of literature. 61
28195081 2017
50
Bilateral Conjunctival Rhinosporidiosis in a Paediatric Patient. 61
29207747 2017

Variations for Rhinosporidiosis

Expression for Rhinosporidiosis

Search GEO for disease gene expression data for Rhinosporidiosis.

Pathways for Rhinosporidiosis

Pathways related to Rhinosporidiosis according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 SERPINA1 NCAM1 IL4 IFNA21 IFNA2 IFNA17
2
Show member pathways
13.11 NCAM1 IL4 IFNA21 IFNA2 IFNA17 FN1
3 12.52 IL4 IFNA21 IFNA2 IFNA17 FN1 BMP2
4
Show member pathways
12.48 IL4 IFNA21 IFNA2 IFNA17 CD8A CD4
5
Show member pathways
12.32 IL4 IFNA21 IFNA2 IFNA17
6
Show member pathways
12.19 IL4 IFNA21 IFNA2 IFNA17
7 11.99 IFNA21 IFNA2 IFNA17 CLEC7A
8
Show member pathways
11.98 IL4 IFNA21 IFNA2 IFNA17 BMP2
9 11.71 IL4 CD8A CD4
10 11.68 NCAM1 FN1 BMP2
11 11.65 IFNA21 IFNA2 IFNA17
12 11.36 NCAM1 IL4 CD8A CD4
13 11.25 IFNA21 IFNA2 IFNA17
14 11.16 NCAM1 IL4 IFNA2 CD8A CD68 CD4
15 11.13 NCAM1 IFNA2 CD8A CD4

GO Terms for Rhinosporidiosis

Cellular components related to Rhinosporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.63 NCAM1 DUOX2 DUOX1 CLEC7A CD4 BMP2
2 extracellular space GO:0005615 9.61 VGF SERPINA1 IL4 IFNA21 IFNA2 IFNA17
3 extracellular region GO:0005576 9.44 VGF SERPINA1 NCAM1 IL4 IFNA21 IFNA2
4 NADPH oxidase complex GO:0043020 9.26 DUOX2 DUOX1

Biological processes related to Rhinosporidiosis according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 NRL IL4 FN1 CLEC7A BMP2
2 adaptive immune response GO:0002250 9.97 IFNA21 IFNA2 IFNA17 CD8A CD4
3 blood coagulation GO:0007596 9.84 SERPINA1 IFNA21 IFNA2 IFNA17
4 type I interferon signaling pathway GO:0060337 9.72 IFNA21 IFNA2 IFNA17
5 humoral immune response GO:0006959 9.7 IFNA21 IFNA2 IFNA17
6 response to cAMP GO:0051591 9.69 VGF DUOX2 DUOX1
7 response to exogenous dsRNA GO:0043330 9.67 IFNA21 IFNA2 IFNA17
8 B cell proliferation GO:0042100 9.65 IFNA21 IFNA2 IFNA17
9 positive regulation of wound healing GO:0090303 9.61 DUOX2 DUOX1 CLEC7A
10 hormone biosynthetic process GO:0042446 9.58 DUOX2 DUOX1
11 T cell activation involved in immune response GO:0002286 9.58 IFNA21 IFNA2 IFNA17
12 hydrogen peroxide biosynthetic process GO:0050665 9.56 DUOX2 DUOX1
13 B cell differentiation GO:0030183 9.56 IL4 IFNA21 IFNA2 IFNA17
14 defense response GO:0006952 9.55 IFNA21 IFNA2 IFNA17 DUOX2 DUOX1
15 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.54 IFNA21 IFNA2 IFNA17
16 natural killer cell activation involved in immune response GO:0002323 9.5 IFNA21 IFNA2 IFNA17
17 cuticle development GO:0042335 9.46 DUOX2 DUOX1
18 T cell activation GO:0042110 9.26 IL4 CLEC7A CD8A CD4
19 cytokine-mediated signaling pathway GO:0019221 9.23 IL4 IFNA21 IFNA2 IFNA17 FN1 DUOX2

Molecular functions related to Rhinosporidiosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.55 IL4 IFNA21 IFNA2 IFNA17 BMP2
2 superoxide-generating NADPH oxidase activity GO:0016175 9.32 DUOX2 DUOX1
3 NAD(P)H oxidase activity GO:0016174 9.26 DUOX2 DUOX1
4 type I interferon receptor binding GO:0005132 9.13 IFNA21 IFNA2 IFNA17
5 cytokine receptor binding GO:0005126 8.92 IL4 IFNA21 IFNA2 IFNA17

Sources for Rhinosporidiosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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