MCID: RCK009
MIFTS: 20

Rickettsial Disease

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Rickettsial Disease

MalaCards integrated aliases for Rickettsial Disease:

Name: Rickettsial Disease 58
Rickettsiae Disease 58

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

UMLS via Orphanet 72 C0035585
Orphanet 58 ORPHA102021

Summaries for Rickettsial Disease

MalaCards based summary : Rickettsial Disease, also known as rickettsiae disease, is related to epidemic typhus and spotted fever. The drugs carbamide peroxide and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and monocytes.

Wikipedia : 74 Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus,... more...

Related Diseases for Rickettsial Disease

Diseases related to Rickettsial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 11.7
2 spotted fever 11.7
3 typhus-group rickettsiosis 11.2
4 scrub typhus 10.6
5 q fever 10.6
6 rocky mountain spotted fever 10.5
7 boutonneuse fever 10.4
8 rickettsialpox 10.3
9 exanthem 10.3
10 ehrlichiosis 10.1
11 brill-zinsser disease 10.1
12 vasculitis 10.1
13 african tick-bite fever 10.1
14 indian tick typhus 10.1
15 brucellosis 10.1
16 acute kidney failure 10.1
17 poliomyelitis 10.1
18 multiple sclerosis 10.0
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
20 human granulocytic anaplasmosis 10.0
21 endemic typhus 10.0
22 mumps 10.0
23 rabies 10.0
24 diphtheria 10.0
25 leptospirosis 10.0
26 chickenpox 10.0
27 encephalitis 10.0
28 headache 10.0
29 pfeiffer syndrome 9.8
30 retinal detachment 9.8
31 anencephaly 9.8
32 immune deficiency disease 9.8
33 ocular motor apraxia 9.8
34 pars planitis 9.8
35 human immunodeficiency virus type 1 9.8
36 leukemia, acute lymphoblastic 9.8
37 human monocytic ehrlichiosis 9.8
38 astrakhan spotted fever 9.8
39 flinders island spotted fever 9.8
40 variola major 9.8
41 sensorineural hearing loss 9.8
42 neuroretinitis 9.8
43 endocarditis 9.8
44 lymphocytic leukemia 9.8
45 meningoencephalitis 9.8
46 queensland tick typhus 9.8
47 japanese encephalitis 9.8
48 siberian tick typhus 9.8
49 trench fever 9.8
50 bartonellosis 9.8

Graphical network of the top 20 diseases related to Rickettsial Disease:



Diseases related to Rickettsial Disease

Symptoms & Phenotypes for Rickettsial Disease

Drugs & Therapeutics for Rickettsial Disease

Drugs for Rickettsial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved 124-43-6
2
Ethanol Approved 64-17-5 702

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rickettsial Disease in Febrile Hospitalised Patients in a Tertiary Referral Hospital in Bangladesh Completed NCT02339259
2 A Multicentre Observational Study to Describe the Prevalence of Scrub Typhus Defined as a Positive Rapid Diagnostic Test Among Selected Patients Presenting With Fever to Clinics in Myanmar Active, not recruiting NCT03269266

Search NIH Clinical Center for Rickettsial Disease

Genetic Tests for Rickettsial Disease

Anatomical Context for Rickettsial Disease

MalaCards organs/tissues related to Rickettsial Disease:

40
Kidney, Testes, Monocytes, Bone, Endothelial, Bone Marrow, Eye

Publications for Rickettsial Disease

Articles related to Rickettsial Disease:

(show top 50) (show all 275)
# Title Authors PMID Year
1
Real-time PCR assay with an endogenous internal amplification control for detection and quantification of Anaplasma marginale in bovine blood. 61
31784419 2020
2
Searching and finding the hidden treasure: Rickettsial disease among Dutch international travelers - a retrospective analysis. 61
31998942 2020
3
Computational selection of minimum length groESL operon required for Anaplasma species attribution and strain diversity analysis. 61
31562909 2019
4
Evaluation of oxidative stress in caprine anaplasmosis and effect of vitamin E-selenium in monitoring oxidative stress. 61
31838717 2019
5
Human Parasitism by Amblyomma parkeri Ticks Infected with Candidatus Rickettsia paranaensis, Brazil. 61
31742531 2019
6
Molecular characterization of Orientia tsutsugamushi causing scrub typhus among febrile patients in north-central Bangladesh. 61
31641512 2019
7
High Seroprevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae among Scrub Typhus Patients in South Korea. 61
31436153 2019
8
Purpuric rash and fever among hospitalized children aged 0-18 years: Comparison between clinical, laboratory, therapeutic and outcome features of patients with bacterial versus viral etiology. 61
30922715 2019
9
New and old hotspots for rickettsial spotted fever acquired in Tasmania, 2012-2017. 61
31268225 2019
10
The epidemiology and clinical features of rickettsial diseases in North Queensland, Australia: Implications for patient identification and management. 61
31318873 2019
11
A biosafety level-2 dose-dependent lethal mouse model of spotted fever rickettsiosis: Rickettsia parkeri Atlantic Rainforest strain. 61
31216274 2019
12
Inflammatory arthritis: a unique presentation of human anaplasmosis. 61
30539351 2019
13
Emerging Roles of Autophagy and Inflammasome in Ehrlichiosis. 61
31134081 2019
14
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
15
Vector Tick Transmission Model of Spotted Fever Rickettsiosis. 61
30315767 2019
16
Ocular manifestations of Rickettsia conorii in South India. 61
30451192 2018
17
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 61
29486240 2018
18
Acute multifocal retinitis: a retrospective review of 35 cases. 61
30328571 2018
19
A Severe Case of Murine Typhus Presenting With Anemia and Severe Thrombocytopenia. 61
29200167 2018
20
A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley, Los Angeles County, California. 61
29677221 2018
21
Detection and molecular characterisation of Ehrlichia canis in naturally infected dogs in South West Nigeria. 61
29580089 2018
22
Scrub Typhus: No Longer Restricted to the Tsutsugamushi Triangle. 61
30274409 2018
23
Canine Monocytic Ehrlichiosis among working dogs of organised kennels in India: A comprehensive analyses of clinico-pathology, serological and molecular epidemiological approach. 61
29254723 2017
24
Kikuchi-Fujimoto disease: an unusual presentation of meningitis in a returning traveller. 61
29170173 2017
25
Evaluation of a Spotted Fever Group Rickettsia Public Health Surveillance System in Tennessee. 61
28722610 2017
26
Spatio-temporal variations and genetic diversity of Anaplasma spp. in cattle from the North of Tunisia. 61
28888642 2017
27
Rickettsia felis Infection in Febrile Children, Ghana. 61
28115672 2017
28
Acute-phase diagnosis of murine and scrub typhus in Belgian travelers by polymerase chain reaction: a case report. 61
28407761 2017
29
Molecular detection of Rickettsia species in ticks collected from the southwestern provinces of the Republic of Korea. 61
28069059 2017
30
Rickettsial Disease in the Peruvian Amazon Basin. 61
27416029 2016
31
Molecular characterization of Ehrlichia canis infecting dogs, Buenos Aires. 61
27236582 2016
32
Scrub typhus and spotted fever among hospitalised children in South India: Clinical profile and serological epidemiology. 61
27514949 2016
33
Scrub Typhus Presenting with Bilateral Lateral Rectus Palsy in A Female. 61
27190871 2016
34
Prevalence of Rickettsia spp. in Ticks and Serological and Clinical Outcomes in Tick-Bitten Individuals in Sweden and on the Åland Islands. 61
27846275 2016
35
An update on the epidemiological situation of spotted fever in Brazil. 61
27555867 2016
36
[Late diagnosis of fatal invasive rickettsial disease in the Intensive Care Unit]. 61
28292166 2016
37
Minocycline as A Substitute for Doxycycline in Targeted Scenarios: A Systematic Review. 61
26719847 2015
38
A case of Mediterranean spotted fever associated with severe respiratory distress syndrome. 61
26344605 2015
39
Parinaud's oculoglandular syndrome revealing subclinical Rickettsia conorii infection. 61
26105087 2015
40
Relapsing Fever: Diagnosis Thanks to a Vigilant Hematology Laboratory. 61
26186517 2015
41
Targeted knockout of the Rickettsia rickettsii OmpA surface antigen does not diminish virulence in a mammalian model system. 61
25827414 2015
42
Aseptic meningitis outbreak associated with echovirus 30 among high school football players--Los Angeles County, California, 2014. 61
25551596 2015
43
Rickettsial infection among military personnel deployed in Northern Sri Lanka. 61
25527099 2014
44
Visual loss associated with rickettsial disease. 61
24171650 2014
45
Acute flaccid paralysis with anterior myelitis - California, June 2012-June 2014. 61
25299608 2014
46
[Clinical analysis of tsutsugamushi disease misdiagnosed as tonsillitis]. 61
24961137 2014
47
Ticks and spotted fever group rickettsiae of southeastern Virginia. 61
24201057 2014
48
Reduced disease in black abalone following mass mortality: phage therapy and natural selection. 61
24672512 2014
49
[Rickettsioses]. 61
24988165 2014
50
Fever in the returning traveler. 61
24176472 2013

Variations for Rickettsial Disease

Expression for Rickettsial Disease

Search GEO for disease gene expression data for Rickettsial Disease.

Pathways for Rickettsial Disease

GO Terms for Rickettsial Disease

Sources for Rickettsial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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