MCID: RCK003
MIFTS: 28

Rickettsialpox

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Rickettsialpox

MalaCards integrated aliases for Rickettsialpox:

Name: Rickettsialpox 12 76 59 73
Rickettsiaceae Infections 44 73
Rickettsia Akari Spotted Fever 12
Vesicular Rickettsiosis 12

Characteristics:

Orphanet epidemiological data:

59
rickettsialpox
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:11103
ICD10 33 A79.1
ICD9CM 35 083.2
MeSH 44 D012288
SNOMED-CT 68 75096007
Orphanet 59 ORPHA83312
UMLS via Orphanet 74 C0035597
ICD10 via Orphanet 34 A79.1

Summaries for Rickettsialpox

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia akari, which is transmitted by house mouse mite (Liponyssoides sanguineus) found on mice and other rodents. The infection has symptom fever, has symptom chills, has symptom headache, has symptom myalgia, and has symptom papulovesicular rash.

MalaCards based summary : Rickettsialpox, also known as rickettsiaceae infections, is related to q fever and hepatitis, and has symptoms including fever, chills and headache. The drugs Doxycycline and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include testes.

Wikipedia : 76 Rickettsialpox is a mite-borne infectious illness caused by bacteria of the genus Rickettsia (Rickettsia... more...

Related Diseases for Rickettsialpox

Diseases related to Rickettsialpox via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 q fever 10.0
2 hepatitis 9.9
3 rocky mountain spotted fever 9.9
4 spotted fever 9.9
5 lymphocytic choriomeningitis 9.9

Graphical network of the top 20 diseases related to Rickettsialpox:



Diseases related to Rickettsialpox

Symptoms & Phenotypes for Rickettsialpox

Symptoms:

12
  • fever
  • chills
  • headache
  • myalgia
  • papulovesicular rash

Drugs & Therapeutics for Rickettsialpox

Drugs for Rickettsialpox (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 564-25-0 54671203
2
Azithromycin Approved Phase 4 83905-01-5 55185 447043
3 Anti-Bacterial Agents Phase 4,Phase 3,Not Applicable
4 Antibiotics, Antitubercular Phase 4,Not Applicable
5 Anti-Infective Agents Phase 4,Phase 3,Not Applicable
6 Antimalarials Phase 4,Phase 3,Not Applicable
7 Antiparasitic Agents Phase 4,Phase 3,Not Applicable
8 Antiprotozoal Agents Phase 4,Phase 3,Not Applicable
9 Antitubercular Agents Phase 4,Not Applicable
10
Telithromycin Approved Phase 3 191114-48-4 5462516 0
11
Rifampicin Approved Not Applicable 13292-46-1 5458213 5381226
12
Ethanol Approved 64-17-5 702
13 Cytochrome P-450 CYP3A Inducers Not Applicable
14 Nucleic Acid Synthesis Inhibitors Not Applicable
15 Antibodies Not Applicable
16 Immunoglobulins Not Applicable
17 Vaccines

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Scrub Typhus Antibiotic Resistance Trial Recruiting NCT03083197 Phase 4 Doxycycline 7 days;Doxycycline 3 days;Azithromycin 3 days
2 Controlled Trial: 5-Day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00351182 Phase 3 Telithromycin;Doxycycline
3 Causes of Fever in Bangladeshi Patients Unknown status NCT02339259
4 Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases Unknown status NCT01137175
5 Controlled Trial: 5-Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus Unknown status NCT00568711 Not Applicable doxycycline;rifampin
6 Rickettsial Genesis to Sarcoidosis in Denmark Completed NCT00326534
7 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830 Not Applicable
8 Scrub Typhus Infection Induced Cardiovascular Disease Recruiting NCT03274869
9 Scrub Typhus RDT Study Recruiting NCT03269266
10 Scrub Typhus Pediatric Immunology Study Recruiting NCT02398162
11 Eschar Investigations in Scrub Typhus Not yet recruiting NCT02915861
12 The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents Not yet recruiting NCT02876367

Search NIH Clinical Center for Rickettsialpox

Cochrane evidence based reviews: rickettsiaceae infections

Genetic Tests for Rickettsialpox

Anatomical Context for Rickettsialpox

MalaCards organs/tissues related to Rickettsialpox:

41
Testes

Publications for Rickettsialpox

Articles related to Rickettsialpox:

(show top 50) (show all 66)
# Title Authors Year
1
Rickettsia Akari (Rickettsialpox) ( 28846279 )
2017
2
Rickettsialpox in a Pediatric Patient. ( 28353525 )
2017
3
A case of rickettsialpox in Northern Europe. ( 22257655 )
2012
4
Human rickettsialpox, southeastern Mexico. ( 19861070 )
2009
5
Hepatitis in association with rickettsialpox. ( 18171106 )
2008
6
Isolation of Rickettsia akari from eschars of patients with rickettsialpox. ( 17038703 )
2006
7
Rickettsial infections around the world, part 2: rickettsialpox, the typhus group, and bioterrorism. ( 16392013 )
2005
8
Rickettsialpox: report of three cases and a review. ( 15577753 )
2004
9
Increased detection of rickettsialpox in a New York City hospital following the anthrax outbreak of 2001: use of immunohistochemistry for the rapid confirmation of cases in an era of bioterrorism. ( 14676069 )
2003
10
Rickettsialpox in New York City: a persistent urban zoonosis. ( 12860597 )
2003
11
Rickettsialpox in a patient with HIV infection. ( 12582406 )
2003
12
Rickettsialpox in Turkey. ( 14725263 )
2003
13
Rickettsialpox in North Carolina: a case report. ( 12095443 )
2002
14
Serologic evidence of rickettsialpox (Rickettsia akari) infection among intravenous drug users in inner-city Baltimore, Maryland. ( 10403316 )
1999
15
Monoclonal antibody-based immunohistochemical diagnosis of rickettsialpox: the macrophage is the principal target. ( 10349992 )
1999
16
Rickettsialpox-like illness in a traveler. ( 9290302 )
1997
17
Rickettsialpox. ( 9098640 )
1997
18
Rickettsialpox. ( 8727130 )
1996
19
Rickettsialpox in a New York City hospital, 1980 to 1989. ( 7969341 )
1994
20
Positive Weil-Felix reactions in a case of rickettsialpox. ( 2722341 )
1989
21
Does epizootic lymphocytic choriomeningitis prime the pump for epidemic rickettsialpox? ( 6658282 )
1983
22
Rickettsialpox. ( 6119522 )
1982
23
Host defenses in experimental rickettsialpox: genetics of natural resistance to infection. ( 7380561 )
1980
24
Host defenses in experimental rickettsialpox: resistance of C3H mouse sublines. ( 6106381 )
1980
25
Rickettsialpox. Case report and epidemiologic review. ( 480648 )
1979
26
Rickettsialpox. ( 5219966 )
1966
27
Rickettsialpox. ( 5220053 )
1966
28
Rickettsialpox: report of a serologically proved case in Cleveland. ( 13272868 )
1956
29
Studies of rickettsialpox. III. Life cycle of the mite vector, Allodermanyssus sanguineus. ( 13138588 )
1954
30
The relationship of the habits of the house mouse and the mouse mite (Allodermanyssus sanguineus) to the spread of rickettsialpox. ( 13065991 )
1953
31
Rickettsialpox. II. Recovery of Rickettsia akari from mites Allodermanyssus sanguineus, from West Hartford, Conn. ( 14949113 )
1952
32
The treatment of rickettsialpox with antibiotics. ( 13139180 )
1952
33
The relationship of the habits of the house mouse and the mouse mite (Allodermanyssus sanguineus) to the spread of rickettsialpox. ( 13136222 )
1952
34
Rickettsialpox; report of four apparent cases in Pennsylvania. ( 12985598 )
1952
35
Rickettsialpox. Report of a case. ( 14832092 )
1951
36
Rickettsialpox case due to laboratory infection. ( 14816492 )
1951
37
Studies of rickettsialpox. I. Recovery of the causative agent from house mice in Boston, Massachusetts. ( 14846793 )
1951
38
Rickettsialpox in Boston; report of a case. ( 14815716 )
1951
39
An undescribed fever resembling varicella and rickettsialpox; preliminary report of 11 cases seen in the transvaal. ( 15418314 )
1950
40
Treatment of rickettsialpox with aureomycin. ( 14771085 )
1950
41
Rickettsialpox and Q fever. ( 14772199 )
1950
42
Rickettsialpox--a new rickettsial disease with oral manifestations; review of literature and case report. ( 14780676 )
1950
43
Use of chloromycetin in a case of rickettsialpox. ( 15416964 )
1950
44
The experimental and clinical evaluation of terramycin against Rickettsia akari (rickettsialpox). ( 14783347 )
1950
45
Rickettsialpox; report of a serologically proved case occurring in a resident of Boston. ( 14780391 )
1950
46
Rickettsialpox; a clinical review with differential diagnostic notes. ( 18148043 )
1949
47
New locality records for Allodermanyssys sanguineus vector of rickettsialpox. ( 18133342 )
1949
48
Clinical aspects of rickettsialpox, Q. fever and Rocky Mountain spotted fever. ( 18142749 )
1949
49
Rickettsialpox; clinical and laboratory study of 12 hospitalized cases. ( 15394677 )
1949
50
The clinical manifestations and laboratory diagnosis of rickettsialpox. ( 15393018 )
1949

Variations for Rickettsialpox

Expression for Rickettsialpox

Search GEO for disease gene expression data for Rickettsialpox.

Pathways for Rickettsialpox

GO Terms for Rickettsialpox

Sources for Rickettsialpox

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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