MCID: RFT001
MIFTS: 47

Rift Valley Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Rift Valley Fever

Summaries for Rift Valley Fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Rift Valley fever virus, which is transmitted by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has symptom jaundice, has symptom vomiting blood, has symptom passing blood in the feces, has symptom ecchymoses (caused by bleeding in the skin), has symptom bleeding from the nose or gums, has symptom menorrhagia and has symptom bleeding from venepuncture sites.

MalaCards based summary : Rift Valley Fever is related to west nile virus and dengue virus, and has symptoms including jaundice, menorrhagia and vomiting blood. An important gene associated with Rift Valley Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are 4-1BB Pathway and Immune response IFN alpha/beta signaling pathway. The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and brain, and related phenotypes are seizures and nausea and vomiting

CDC : 3 Rift Valley fever (RVF) is an acute, fever-causing viral disease most commonly observed in domesticated animals (such as cattle, buffalo, sheep, goats, and camels), with the ability to infect and cause illness in humans. The disease is caused by RVF virus (RVFV), a member of the genus Phlebovirus in the family Bunyaviridae. It was first reported in livestock by veterinary officers in Kenya’s Rift Valley in the early 1910s.

Wikipedia : 76 Rift Valley fever (RVF) is a viral disease that can cause mild to severe symptoms. The mild symptoms may... more...

Related Diseases for Rift Valley Fever

Diseases related to Rift Valley Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 west nile virus 30.7 CD209 IFITM3
2 dengue virus 30.2 CD209 IFITM3
3 coccidioidomycosis 11.6
4 viral infectious disease 11.0
5 encephalitis 10.6
6 crimean-congo hemorrhagic fever 10.5
7 hemorrhagic fever 10.5
8 brucellosis 10.4
9 hepatitis 10.3
10 chikungunya 10.3
11 q fever 10.3
12 west nile fever 10.3
13 influenza 10.3
14 skin disease 10.1
15 thrombocytopenia 10.1
16 tick-borne encephalitis 10.1
17 japanese encephalitis 10.1
18 disseminated intravascular coagulation 10.1
19 phlebotomus fever 10.1
20 hepatorenal syndrome 10.1
21 hepatitis a 10.1
22 uveitis 10.1
23 diarrhea 10.1
24 lymphogranuloma venereum 10.1
25 newcastle disease 10.1
26 vaccinia 10.1
27 plague 10.1
28 retinitis 10.1
29 avian influenza 10.1
30 hydranencephaly 10.1
31 viral encephalitis 10.1
32 lassa fever 10.1
33 venezuelan equine encephalitis 10.1
34 yellow fever 10.1
35 xanthogranulomatous cholecystitis 10.1
36 anterior uveitis 10.1
37 endotheliitis 10.1
38 severe acute respiratory syndrome 9.9 CD209 MX1
39 lichen planus 9.6 MX1 TP53

Graphical network of the top 20 diseases related to Rift Valley Fever:



Diseases related to Rift Valley Fever

Symptoms & Phenotypes for Rift Valley Fever

Symptoms:

12
  • jaundice
  • menorrhagia
  • vomiting blood
  • passing blood in the feces
  • ecchymoses (
  • bleeding from the nose or gums
  • bleeding from venepuncture sites

Human phenotypes related to Rift Valley Fever:

59 32 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
2 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
3 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
4 hallucinations 59 32 frequent (33%) Frequent (79-30%) HP:0000738
5 retinopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000488
6 photophobia 59 32 frequent (33%) Frequent (79-30%) HP:0000613
7 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
8 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
9 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
10 weight loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0001824
11 limitation of joint mobility 59 32 frequent (33%) Frequent (79-30%) HP:0001376
12 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952
13 anorexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002039
14 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
15 chemosis 59 32 frequent (33%) Frequent (79-30%) HP:0012375
16 vertigo 59 32 frequent (33%) Frequent (79-30%) HP:0002321
17 visual loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0000572
18 coma 59 32 occasional (7.5%) Occasional (29-5%) HP:0001259
19 purpura 59 32 occasional (7.5%) Occasional (29-5%) HP:0000979
20 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
21 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
22 meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001287
23 bruising susceptibility 59 32 occasional (7.5%) Occasional (29-5%) HP:0000978
24 hepatic failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001399
25 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
26 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
27 cardiac arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0001695
28 scotoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0000575
29 hemianopsia 59 Occasional (29-5%)
30 cholestasis 59 Occasional (29-5%)
31 abnormality of retinal arteries 59 Occasional (29-5%)
32 hemianopia 32 occasional (7.5%) HP:0012377
33 abnormal retinal artery morphology 32 occasional (7.5%) HP:0000630

Drugs & Therapeutics for Rift Valley Fever

Drugs for Rift Valley Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety/Immunogenicity/Genetic Drift of MP-12 Rift Valley Fever Vaccine Completed NCT00415051 Phase 2
2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine Completed NCT00584194 Phase 2
3 Phase 2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine Recruiting NCT03609398 Phase 2
4 Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated Enrolling by invitation NCT00869713 Phase 2
5 Rift Valley Fever in Kenya Completed NCT00287014

Search NIH Clinical Center for Rift Valley Fever

Cochrane evidence based reviews: rift valley fever

Genetic Tests for Rift Valley Fever

Anatomical Context for Rift Valley Fever

MalaCards organs/tissues related to Rift Valley Fever:

41
Liver, Skin, Brain, Testes, T Cells, Monocytes, Endothelial

Publications for Rift Valley Fever

Articles related to Rift Valley Fever:

(show top 50) (show all 1004)
# Title Authors Year
1
Vascular permeability in the brain is a late pathogenic event during Rift Valley fever virus encephalitis in rats. ( 30396029 )
2019
2
Benefits of a one health approach: An example using Rift Valley fever. ( 29911162 )
2018
3
Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication. ( 29652799 )
2018
4
Enhanced surveillance for Rift Valley Fever in livestock during El NiA+o rains and threat of RVF outbreak, Kenya, 2015-2016. ( 29698487 )
2018
5
Expression of a Recombinant Nucleocapsid Protein of Rift Valley Fever Virus in Vero Cells as an Immunofluorescence Antigen and Its Use for Serosurveillance in Traditional Cattle Herds in Zambia. ( 29652643 )
2018
6
Mutation of adjacent cysteine residues in the NSs protein of Rift Valley fever virus results in loss of virulence in mice. ( 29530722 )
2018
7
Rift Valley Fever in Egypt and other African countries: Historical review, recent outbreaks and possibility of disease occurrence in Egypt. ( 29391128 )
2018
8
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. ( 29727450 )
2018
9
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound. ( 29386590 )
2018
10
Ecological distribution and population dynamics of Rift Valley fever virus mosquito vectors (Diptera, Culicidae) in Senegal. ( 29316967 )
2018
11
Peripheral Blood Biomarkers of Disease Outcome in a Monkey Model of Rift Valley Fever Encephalitis. ( 29118127 )
2018
12
Seroprevalence of Rift Valley Fever Virus Antibodies in Cattle in Mali, 2005-2014. ( 29363462 )
2018
13
Vector competence of Culex antennatus and Anopheles coustani mosquitoes for Rift Valley fever virus in Madagascar. ( 29383746 )
2018
14
Culex flavivirus infection in a Culex pipiens mosquito colony and its effects on vector competence for Rift Valley fever phlebovirus. ( 29792223 )
2018
15
Development of monoclonal antibodies to Rift Valley Fever Virus and their application in antigen detection and indirect immunofluorescence. ( 29894749 )
2018
16
Prevalence and risk factors of Rift Valley fever in humans and animals from Kabale district in Southwestern Uganda, 2016. ( 29723189 )
2018
17
Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates. ( 29742102 )
2018
18
Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters. ( 29864447 )
2018
19
Evaluation of Fluorescence Microsphere Immunoassay for Detection of Antibodies to Rift Valley Fever Virus Nucleocapsid Protein and Glycoproteins. ( 29563201 )
2018
20
Phosphoproteomic analysis reveals Smad protein family activation following Rift Valley fever virus infection. ( 29408900 )
2018
21
Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon. ( 29625611 )
2018
22
Datasets for mapping pastoralist movement patterns and risk zones of Rift Valley fever occurrence. ( 29276743 )
2018
23
A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting. ( 29707242 )
2018
24
Interspecific network centrality, host range and early-life development are associated with wildlife hosts of Rift Valley fever virus. ( 29756406 )
2018
25
Experimental transmission of West Nile Virus and Rift Valley Fever Virus by Culex pipiens from Lebanon. ( 29324834 )
2018
26
Correction: Phosphoproteomic analysis reveals Smad protein family activation following Rift Valley fever virus infection. ( 29543894 )
2018
27
Epidemiological surveillance of bovine viral diarrhea and rift valley fever infections in camel. ( 30410242 )
2018
28
CD4 T cells, CD8 T cells, and monocytes coordinate to prevent Rift Valley fever virus encephalitis. ( 30258000 )
2018
29
Quantifying the potential pathways and locations of Rift Valley fever virus entry into the United States. ( 28191786 )
2018
30
Packaging of Rift Valley fever virus pseudoviruses and establishment of a neutralization assay method. ( 28693302 )
2018
31
Understanding the legal trade of cattle and camels and the derived risk of Rift Valley Fever introduction into and transmission within Egypt. ( 29351273 )
2018
32
A phytosociological analysis and description of wetland vegetation and ecological factors associated with locations of high mortality for the 2010-11 Rift Valley fever outbreak in South Africa. ( 29462214 )
2018
33
Efficacy of different DNA and MVA prime-boost vaccination regimens against a Rift Valley fever virus (RVFV) challenge in sheep 12 weeks following vaccination. ( 29467018 )
2018
34
Expression of cytokines following vaccination of goats with a recombinant capripoxvirus vaccine expressing Rift Valley fever virus proteins. ( 29475501 )
2018
35
Rift Valley Fever: A survey of knowledge, attitudes, and practice of slaughterhouse workers and community members in Kabale District, Uganda. ( 29505579 )
2018
36
Neutralizing antibodies against flaviviruses, Babanki virus, and Rift Valley fever virus in Ugandan bats. ( 29511459 )
2018
37
Rift Valley fever vaccines: current and future needs. ( 29514112 )
2018
38
Competence of mosquitoes native to the United Kingdom to support replication and transmission of Rift Valley fever virus. ( 29776384 )
2018
39
Rift Valley fever in animals and humans: Current perspectives. ( 29857007 )
2018
40
Sero-prevalence and spatial distribution of Rift Valley fever infection among agro-pastoral and pastoral communities during Interepidemic period in the Serengeti ecosystem, northern Tanzania. ( 29898686 )
2018
41
Human Biomarkers of Outcome Following Rift Valley Fever Virus Infection. ( 29955891 )
2018
42
Effect of butylated hydroxyl toluene on the immune response of Rift Valley fever vaccine in a murine model. ( 30015236 )
2018
43
Environmental limits of Rift Valley fever revealed using ecoepidemiological mechanistic models. ( 30021855 )
2018
44
Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice. ( 30028878 )
2018
45
Systematic literature review of Rift Valley fever virus seroprevalence in livestock, wildlife and humans in Africa from 1968 to 2016. ( 30036382 )
2018
46
Seroprevalence and Virus Activity of Rift Valley Fever in Cattle in Eastern Region of Democratic Republic of the Congo. ( 30050953 )
2018
47
Susceptibility of White-Tailed Deer to Rift Valley Fever Virus. ( 30124402 )
2018
48
Rift Valley fever seroprevalence and abortion frequency among livestock of Kisoro district, South Western Uganda (2016): a prerequisite for zoonotic infection. ( 30176865 )
2018
49
Human Cases of Rift Valley Fever in South Africa, 2018. ( 30183525 )
2018
50
Equine immunoglobulin F(ab')2 fragments protect mice from Rift Valley fever virus infection. ( 30199846 )
2018

Variations for Rift Valley Fever

Expression for Rift Valley Fever

Search GEO for disease gene expression data for Rift Valley Fever.

Pathways for Rift Valley Fever

Pathways related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.93 BCL2L10 PRKCE TP53
2
Show member pathways
11.13 IFITM3 MX1 PRKCE TP53
3 10.82 CD209 CD83

GO Terms for Rift Valley Fever

Biological processes related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type I interferon signaling pathway GO:0060337 9.26 IFITM3 MX1
2 nucleotide-excision repair GO:0006289 9.16 GTF2H1 TP53
3 negative regulation of viral genome replication GO:0045071 8.96 IFITM3 MX1
4 apoptotic process GO:0006915 8.92 BCL2L10 MX1 PRKCE TP53

Molecular functions related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 BCL2L10 CD209 CD83 GTF2H1 IFITM3 MX1

Sources for Rift Valley Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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