MCID: RFT001
MIFTS: 47

Rift Valley Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Rift Valley Fever

MalaCards integrated aliases for Rift Valley Fever:

Name: Rift Valley Fever 12 74 58 54 3 43 15 71 32

Characteristics:

Orphanet epidemiological data:

58
rift valley fever
Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Rift Valley Fever

CDC : 3 Rift Valley fever (RVF) is an acute, fever-causing viral disease most commonly observed in domesticated animals (such as cattle, buffalo, sheep, goats, and camels), with the ability to infect and cause illness in humans. The disease is caused by RVF virus (RVFV), a member of the genus Phlebovirus in the family Bunyaviridae. It was first reported in livestock by veterinary officers in Kenya's Rift Valley in the early 1910s. RVF is generally found in regions of eastern and southern Africa where sheep and cattle are raised, but the virus exists in most of sub-Saharan Africa, including west Africa and Madagascar. In September 2000, a RVF outbreak was reported in Saudi Arabia and subsequently, Yemen. This outbreak represents the first cases of Rift Valley fever identified outside Africa. Outbreaks of RVF can have major societal impacts, including significant economic losses and trade reductions. The virus most commonly affects livestock, causing disease and abortion in domesticated animals, an important income source for many. Outbreaks of disease in animal populations are called "epizootics." The most notable RVF epizootic occurred in Kenya in 1950-1951, resulting in the death of an estimated 100,000 sheep. Additionally, epizootic outbreaks of RVF increase the likelihood of contact between diseased animals and humans, which can lead to epidemics of RVF in humans. One example occurred in 1977 when the virus was detected in Egypt (possibly imported from infected domestic animals from Sudan) and caused a large outbreak of RVF among both animals and humans resulting in over 600 human deaths. Another example of RVF spillover into human populations occurred in west Africa in 1987, and was linked to construction of the Senegal River Project. The project caused flooding in the lower Senegal River area, altering ecological conditions and interactions between animals and humans. As a result, a large RVF outbreak occurred in animals and humans.

MalaCards based summary : Rift Valley Fever is related to west nile virus and newcastle disease, and has symptoms including jaundice, menorrhagia and vomiting blood. An important gene associated with Rift Valley Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Cytokine Signaling in Immune system and 4-1BB Pathway. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include liver, skin and brain, and related phenotypes are fatigue and fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Rift Valley fever virus, which is transmitted by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has symptom jaundice, has symptom vomiting blood, has symptom passing blood in the feces, has symptom ecchymoses (caused by bleeding in the skin), has symptom bleeding from the nose or gums, has symptom menorrhagia and has symptom bleeding from venepuncture sites.

Wikipedia : 74 Rift Valley fever (RVF) is a viral disease that can cause mild to severe symptoms. The mild symptoms may... more...

Related Diseases for Rift Valley Fever

Diseases related to Rift Valley Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 107)
# Related Disease Score Top Affiliating Genes
1 west nile virus 31.1 IFITM3 IFITM2 IFITM1 CD209
2 newcastle disease 30.9 TP53 EIF2S1 EIF2AK2
3 dengue virus 30.6 IFITM3 IFITM2 IFITM1 CD209
4 west nile fever 30.4 PRNT CD40LG CD209
5 lassa fever 30.4 IFITM3 CD40LG CD209
6 west nile encephalitis 30.3 PRNT CD40LG
7 phlebotomus fever 30.0 SAP30 PRNT GTF2H1 CD40LG
8 stomatitis 30.0 MX1 IFITM3 IFITM2 EIF2AK2 CD40LG
9 st. louis encephalitis 29.9 PRNT CD40LG
10 viral infectious disease 29.8 MX1 EIF2S1 EIF2AK2 CD40LG CD209
11 influenza 29.3 MX1 IFITM3 IFITM2 IFITM1 EIF2S1 EIF2AK2
12 coccidioidomycosis 11.7
13 encephalitis 10.9
14 neuroretinitis 10.9
15 retinitis 10.9
16 yemenite deaf-blind hypopigmentation syndrome 10.8
17 crimean-congo hemorrhagic fever 10.7
18 yellow fever 10.7
19 chikungunya 10.6
20 meningoencephalitis 10.6
21 vaccinia 10.6
22 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.6
23 disseminated intravascular coagulation 10.6
24 diarrhea 10.6
25 viral hemorrhagic fever 10.6
26 triiodothyronine receptor auxiliary protein 10.5
27 brucellosis 10.4
28 plague 10.4
29 venezuelan equine encephalitis 10.4
30 arbovirosis 10.4
31 japanese encephalitis 10.4
32 q fever 10.4
33 rabies 10.4
34 hepatorenal syndrome 10.4
35 neutropenia 10.4
36 skin disease 10.4
37 48,xyyy 10.4
38 ataxia and polyneuropathy, adult-onset 10.3
39 uveitis 10.3
40 thrombocytopenia 10.3
41 hemorrhagic disease 10.3
42 acute kidney failure 10.3
43 mouth disease 10.3
44 ebola hemorrhagic fever 10.3
45 avian influenza 10.3
46 hydranencephaly 10.3
47 poliomyelitis 10.3
48 lymphopenia 10.3
49 vasculitis 10.3
50 iridocyclitis 10.3

Graphical network of the top 20 diseases related to Rift Valley Fever:



Diseases related to Rift Valley Fever

Symptoms & Phenotypes for Rift Valley Fever

Human phenotypes related to Rift Valley Fever:

58 31 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 hallucinations 58 31 frequent (33%) Frequent (79-30%) HP:0000738
4 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
5 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
6 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
7 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
8 vertigo 58 31 frequent (33%) Frequent (79-30%) HP:0002321
9 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
10 limitation of joint mobility 58 31 frequent (33%) Frequent (79-30%) HP:0001376
11 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
12 chemosis 58 31 frequent (33%) Frequent (79-30%) HP:0012375
13 retinopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000488
14 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
15 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
16 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
17 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
18 purpura 58 31 occasional (7.5%) Occasional (29-5%) HP:0000979
19 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
20 bruising susceptibility 58 31 occasional (7.5%) Occasional (29-5%) HP:0000978
21 hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001399
22 lethargy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001254
23 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
24 scotoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0000575
25 hemianopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0012377
26 visual loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0000572
27 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
28 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695
29 seizure 31 occasional (7.5%) HP:0001250
30 abnormal retinal artery morphology 31 occasional (7.5%) HP:0000630
31 seizures 58 Occasional (29-5%)
32 cholestasis 58 Occasional (29-5%)
33 abnormality of retinal arteries 58 Occasional (29-5%)

Symptoms:

12
  • jaundice
  • menorrhagia
  • vomiting blood
  • passing blood in the feces
  • ecchymoses
  • bleeding from the nose
  • bleeding from venepuncture sites

Drugs & Therapeutics for Rift Valley Fever

Drugs for Rift Valley Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parts A&B: Evaluation of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200), A Phase 2 Study Completed NCT00584194 Phase 2
2 Safety and Immunogenicity of Live-Attenuated MP-12 Rift Valley Fever Vaccine in Humans, and Genetic Characterization of Virus Isolates Recovered From the Blood of Vaccinated Volunteers: A Phase II Study Completed NCT00415051 Phase 2
3 A Phase 2 Open Label Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated, Dried, TSI-GSD 200, Lot 7, Run 2, in Adult Subjects at Risk of Exposure to Rift Valley Fever Virus Recruiting NCT03609398 Phase 2
4 Long-Term Open-Label Primary Vaccination and Booster Dose Study of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200) in At-Risk Adults Active, not recruiting NCT00869713 Phase 2
5 Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Completed NCT03055000 Phase 1
6 Late Outcomes of Rift Valley Fever in Kenya: Ijara Clinical Survey Completed NCT00287014

Search NIH Clinical Center for Rift Valley Fever

Cochrane evidence based reviews: rift valley fever

Genetic Tests for Rift Valley Fever

Anatomical Context for Rift Valley Fever

MalaCards organs/tissues related to Rift Valley Fever:

40
Liver, Skin, Brain, Testes, T Cells, Monocytes, Kidney

Publications for Rift Valley Fever

Articles related to Rift Valley Fever:

(show top 50) (show all 1878)
# Title Authors PMID Year
1
The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirus. 54 61
17970694 2007
2
Theoretical risk of genetic reassortment should not impede development of live, attenuated Rift Valley fever (RVF) vaccines commentary on the draft WHO RVF Target Product Profile. 61
32337506 2020
3
Transboundary Animal Diseases (TADs) affecting domestic and wild African ungulates: African swine fever, foot and mouth disease, Rift Valley fever (1996-2018). 61
32311588 2020
4
The V1016G mutation of the voltage-gated sodium channel (VGSC) gene contributes to the insecticide resistance of Aedes aegypti from Makassar, Indonesia. 61
32458116 2020
5
First serological evidence of the Rift Valley fever Phlebovirus in Tunisian camels. 61
32325049 2020
6
Risk assessment for the Rift Valley fever occurrence in China: Special concern in southwest border areas. 61
32568445 2020
7
Rift Valley Fever: Important Considerations for Risk Mitigation and Future Outbreaks. 61
32498264 2020
8
Mobile Laboratory Reveals the Circulation of Dengue Virus Serotype I of Asian Origin in Medina Gounass (Guediawaye), Senegal. 61
32560073 2020
9
Effect of Environmental Temperature on the Ability of Culex tarsalis and Aedes taeniorhynchus (Diptera: Culicidae) to Transmit Rift Valley Fever Virus. 61
32017863 2020
10
Rift Valley fever in northern Senegal: A modelling approach to analyse the processes underlying virus circulation recurrence. 61
32479505 2020
11
A genome-wide CRISPR-Cas9 screen reveals the requirement of host cell sulfation for Schmallenberg virus infection. 61
32522852 2020
12
The Cytocidal Spectrum of Bacillus thuringiensis Toxins: From Insects to Human Cancer Cells. 61
32384723 2020
13
Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. 61
32397953 2020
14
Novel Ionophores Active against La Crosse Virus Identified through Rapid Antiviral Screening. 61
32284379 2020
15
Reagents for detection of Rift Valley fever virus infection in sheep. 61
32450762 2020
16
Comparative analysis of codon usage patterns in Rift Valley fever virus. 61
32422647 2020
17
A DNA Vaccine Delivery Platform Based on Elastin-Like Recombinamer Nanosystems for Rift Valley Fever Virus. 61
32233501 2020
18
Early Pathogenesis of Wesselsbron Disease in Pregnant Ewes. 61
32414152 2020
19
Mapping livestock movements in Sahelian Africa. 61
32433590 2020
20
Genetic dissection of Rift Valley fever pathogenesis: Rvfs2 locus on mouse chromosome 11 enables survival to early-onset hepatitis. 61
32457349 2020
21
Neutralizing antibodies against Rift Valley fever virus in wild antelope in far northern KwaZulu-Natal, South Africa, indicate recent virus circulation. 61
31943795 2020
22
Relative Distribution, Diversity, and Bloodmeal Sources of Mosquitoes and Known Vectors of Rift Valley Fever Phlebovirus in Three Differing Ecosystems in Bura, Tana River County, Kenya. 61
31990632 2020
23
Systematic Review of Important Viral Diseases in Africa in Light of the 'One Health' Concept. 61
32325980 2020
24
Rift Valley Fever Outbreak, Mayotte, France, 2018-2019. 61
32186500 2020
25
Seroprevalence and associated risk factors of Rift Valley fever in cattle and selected wildlife species at the livestock/wildlife interface areas of Gonarezhou National Park, Zimbabwe. 61
32370521 2020
26
Identification of Bunyamwera and Possible Other Orthobunyavirus Infections and Disease in Cattle during a Rift Valley Fever Outbreak in Rwanda in 2018. 61
32314686 2020
27
Microencapsulated plasmids expressing Gn and Gc glycoproteins of Rift Valley Fever virus enhance humoral immune response in mice. 61
31983039 2020
28
Sero-Epidemiological Study of Selected Zoonotic and Abortifacient Pathogens in Cattle at a Wildlife-Livestock Interface in South Africa. 61
31841655 2020
29
Identification and RNAi Profile of a Novel Iflavirus Infecting Senegalese Aedes vexans arabiensis Mosquitoes. 61
32295109 2020
30
Multimeric single-domain antibody complexes protect against bunyavirus infections. 61
32314955 2020
31
Health of African Buffalos (Syncerus caffer) in Ruaha National Park, Tanzania. 61
31833815 2020
32
Elongin C Contributes to RNA Polymerase II Degradation by the Interferon Antagonist NSs of La Crosse Orthobunyavirus. 61
31941775 2020
33
Seroprevalence of some viral and bacterial zoonoses in domestic ruminants in Medina. 61
32219108 2020
34
Two monoclonal antibodies against glycoprotein Gn protect mice from Rift Valley Fever challenge by cooperative effects. 61
32160203 2020
35
Seroprevalence of Rift valley fever in South African domestic and wild suids (1999-2016). 61
31655018 2020
36
Chitosan and chitosan nanoparticles as adjuvant in local Rift Valley Fever inactivated vaccine. 61
32089983 2020
37
Current status and evolving approaches to African swine fever vaccine development. 61
31538406 2020
38
A comment on 'Seroprevalence of Rift Valley fever in South African domestic and wild suids (1999-2016)'. 61
31898395 2020
39
Patterns of Rift Valley fever virus seropositivity in domestic ruminants in central South Africa four years after a large outbreak. 61
32218486 2020
40
Methods for successful inactivation of Rift Valley fever virus in infected mosquitoes. 61
31794780 2020
41
Characterization of Two Neutralizing Antibodies against Rift Valley Fever Virus Gn Protein. 61
32120864 2020
42
Mechanisms of inter-epidemic maintenance of Rift Valley fever phlebovirus. 61
31870761 2020
43
The use of mice lacking type I or both type I and type II interferon responses in research on hemorrhagic fever viruses. Part 2: Vaccine efficacy studies. 61
31982149 2020
44
Co-expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants. 61
32096288 2020
45
Controlling mosquitoes with semiochemicals: a review. 61
32066499 2020
46
Mosquito-borne viral diseases in the Democratic Republic of the Congo: a review. 61
32103776 2020
47
Finding equipoise: CEPI revises its equitable access policy. 61
32005536 2020
48
MVA Vectored Vaccines Encoding Rift Valley Fever Virus Glycoproteins Protect Mice against Lethal Challenge in the Absence of Neutralizing Antibody Responses. 61
32059491 2020
49
High risk for human exposure to Rift Valley fever virus in communities living along livestock movement routes: A cross-sectional survey in Kenya. 61
32084127 2020
50
Lyophilized Matrix Containing Ready-to-Use Primers and Probe Solution for Standardization of Real-Time PCR and RT-qPCR Diagnostics in Virology. 61
32019076 2020

Variations for Rift Valley Fever

Expression for Rift Valley Fever

Search GEO for disease gene expression data for Rift Valley Fever.

Pathways for Rift Valley Fever

Pathways related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 TP53 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
2
Show member pathways
12.25 TP53 PRKCE EIF2S1 EIF2AK2 CD40LG
3
Show member pathways
12.14 TP53 SAP30 MX1 EIF2S1 EIF2AK2 CD209
4
Show member pathways
12.05 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
5
Show member pathways
11.31 TP53 PRKCE MX1 IFITM3 IFITM2 IFITM1
6
Show member pathways
11.28 PABPC1 EIF2S1 EIF2AK2

GO Terms for Rift Valley Fever

Cellular components related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.5 TP53 SLC4A1 RNASEK PRKCE PABPC1 MX1

Biological processes related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10 PRKCE MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
2 innate immune response GO:0045087 9.95 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2 CD209
3 type I interferon signaling pathway GO:0060337 9.67 MX1 IFITM3 IFITM2 IFITM1
4 response to virus GO:0009615 9.65 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
5 defense response to virus GO:0051607 9.63 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2 DDX17
6 response to interferon-gamma GO:0034341 9.61 IFITM3 IFITM2 IFITM1
7 negative regulation of viral entry into host cell GO:0046597 9.58 IFITM3 IFITM2 IFITM1
8 response to interferon-beta GO:0035456 9.5 IFITM3 IFITM2 IFITM1
9 negative regulation of viral genome replication GO:0045071 9.35 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
10 response to interferon-alpha GO:0035455 8.92 IFITM3 IFITM2 IFITM1 EIF2AK2

Sources for Rift Valley Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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