MCID: RFT001
MIFTS: 46

Rift Valley Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Rift Valley Fever

Summaries for Rift Valley Fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Rift Valley fever virus, which is transmitted by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has symptom jaundice, has symptom vomiting blood, has symptom passing blood in the feces, has symptom ecchymoses (caused by bleeding in the skin), has symptom bleeding from the nose or gums, has symptom menorrhagia and has symptom bleeding from venepuncture sites.

MalaCards based summary : Rift Valley Fever is related to hemorrhagic fever and dengue virus, and has symptoms including jaundice, vomiting blood and passing blood in the feces. An important gene associated with Rift Valley Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are 4-1BB Pathway and UVA-Induced MAPK Signaling. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related phenotypes are retinopathy and visual loss

CDC : 3 Rift Valley fever (RVF) is an acute, fever-causing viral disease most commonly observed in domesticated animals (such as cattle, buffalo, sheep, goats, and camels), with the ability to infect and cause illness in humans. The disease is caused by RVF virus (RVFV), a member of the genus Phlebovirus in the family Bunyaviridae. It was first reported in livestock by veterinary officers in Kenya’s Rift Valley in the early 1910s.

Wikipedia : 76 Rift Valley fever (RVF) is a viral disease that can cause mild to severe symptoms. The mild symptoms may... more...

Related Diseases for Rift Valley Fever

Diseases related to Rift Valley Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 hemorrhagic fever 31.0 CD209 CD40LG
2 dengue virus 29.9 CD209 IFITM3
3 west nile virus 29.6 CD209 IFITM3 MX1
4 coccidioidomycosis 11.4
5 encephalitis 10.4
6 crimean-congo hemorrhagic fever 10.4
7 brucellosis 10.3
8 secondary syphilis 10.3 CD209 CD40LG
9 facial hemiatrophy 10.2 CD40LG SLC4A1
10 hepatitis 10.2
11 q fever 10.2
12 dengue disease 10.2 CD209 CD40LG
13 chikungunya 10.1
14 mucositis 10.1
15 west nile fever 10.1
16 influenza 10.1
17 viral hemorrhagic fever 10.1
18 dengue hemorrhagic fever 10.1 CD209 CD40LG
19 leprosy 3 10.1 CD209 CD40LG
20 severe acute respiratory syndrome 10.0 CD209 CD40LG
21 multiple cranial nerve palsy 10.0 CD40LG TP53
22 skin disease 10.0
23 thrombocytopenia 10.0
24 tick-borne encephalitis 10.0
25 japanese encephalitis 10.0
26 disseminated intravascular coagulation 10.0
27 phlebotomus fever 10.0
28 hepatorenal syndrome 10.0
29 goiter 10.0
30 hepatitis a 10.0
31 uveitis 10.0
32 lymphogranuloma venereum 10.0
33 newcastle disease 10.0
34 retinitis 10.0
35 avian influenza 10.0
36 hydranencephaly 10.0
37 viral encephalitis 10.0
38 lassa fever 10.0
39 venezuelan equine encephalitis 10.0
40 yellow fever 10.0
41 type i 10.0
42 anterior uveitis 10.0
43 endotheliitis 10.0
44 mature b-cell neoplasm 9.9 CD40LG TP53
45 exanthema subitum 9.9 CD40LG CD83
46 encephalitozoonosis 9.7 CD40LG MX1
47 cutaneous lupus erythematosus 9.6 CD40LG MX1
48 rabies 9.3 CD40LG MX1
49 viral infectious disease 9.3 CD209 CD40LG MX1
50 lichen disease 9.1 CD40LG MX1 TP53

Graphical network of the top 20 diseases related to Rift Valley Fever:



Diseases related to Rift Valley Fever

Symptoms & Phenotypes for Rift Valley Fever

Symptoms:

12
  • jaundice
  • vomiting blood
  • passing blood in the feces
  • ecchymoses (
  • bleeding from the nose or gums
  • menorrhagia
  • bleeding from venepuncture sites

Human phenotypes related to Rift Valley Fever:

59 32 (show all 33)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 retinopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0000488
2 visual loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0000572
3 scotoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0000575
4 photophobia 59 32 frequent (33%) Frequent (79-30%) HP:0000613
5 hallucinations 59 32 frequent (33%) Frequent (79-30%) HP:0000738
6 jaundice 59 32 occasional (7.5%) Occasional (29-5%) HP:0000952
7 bruising susceptibility 59 32 occasional (7.5%) Occasional (29-5%) HP:0000978
8 purpura 59 32 occasional (7.5%) Occasional (29-5%) HP:0000979
9 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
10 lethargy 59 32 occasional (7.5%) Occasional (29-5%) HP:0001254
11 coma 59 32 occasional (7.5%) Occasional (29-5%) HP:0001259
12 meningitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001287
13 limitation of joint mobility 59 32 frequent (33%) Frequent (79-30%) HP:0001376
14 hepatic failure 59 32 occasional (7.5%) Occasional (29-5%) HP:0001399
15 cardiac arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0001695
16 weight loss 59 32 occasional (7.5%) Occasional (29-5%) HP:0001824
17 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
18 diarrhea 59 32 frequent (33%) Frequent (79-30%) HP:0002014
19 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%) HP:0002017
20 anorexia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002039
21 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
22 headache 59 32 frequent (33%) Frequent (79-30%) HP:0002315
23 vertigo 59 32 frequent (33%) Frequent (79-30%) HP:0002321
24 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
25 arthralgia 59 32 frequent (33%) Frequent (79-30%) HP:0002829
26 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
27 chemosis 59 32 frequent (33%) Frequent (79-30%) HP:0012375
28 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
29 abnormality of retinal arteries 59 Occasional (29-5%)
30 cholestasis 59 Occasional (29-5%)
31 hemianopsia 59 Occasional (29-5%)
32 abnormal retinal artery morphology 32 occasional (7.5%) HP:0000630
33 hemianopia 32 occasional (7.5%) HP:0012377

Drugs & Therapeutics for Rift Valley Fever

Drugs for Rift Valley Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety/Immunogenicity/Genetic Drift of MP-12 Rift Valley Fever Vaccine Completed NCT00415051 Phase 2
2 Safety and Immunogenicity Study of Rift Valley Fever Vaccine Completed NCT00584194 Phase 2
3 Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated Enrolling by invitation NCT00869713 Phase 2
4 Rift Valley Fever in Kenya Completed NCT00287014

Search NIH Clinical Center for Rift Valley Fever

Cochrane evidence based reviews: rift valley fever

Genetic Tests for Rift Valley Fever

Anatomical Context for Rift Valley Fever

MalaCards organs/tissues related to Rift Valley Fever:

41
Skin, Liver, Brain, Testes, T Cells, Endothelial, Kidney

Publications for Rift Valley Fever

Articles related to Rift Valley Fever:

(show top 50) (show all 679)
# Title Authors Year
1
Benefits of a one health approach: An example using Rift Valley fever. ( 29911162 )
2018
2
Combination Kinase Inhibitor Treatment Suppresses Rift Valley Fever Virus Replication. ( 29652799 )
2018
3
Enhanced surveillance for Rift Valley Fever in livestock during El NiA+o rains and threat of RVF outbreak, Kenya, 2015-2016. ( 29698487 )
2018
4
Expression of a Recombinant Nucleocapsid Protein of Rift Valley Fever Virus in Vero Cells as an Immunofluorescence Antigen and Its Use for Serosurveillance in Traditional Cattle Herds in Zambia. ( 29652643 )
2018
5
Mutation of adjacent cysteine residues in the NSs protein of Rift Valley fever virus results in loss of virulence in mice. ( 29530722 )
2018
6
Rift Valley Fever in Egypt and other African countries: Historical review, recent outbreaks and possibility of disease occurrence in Egypt. ( 29391128 )
2018
7
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. ( 29727450 )
2018
8
Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound. ( 29386590 )
2018
9
Ecological distribution and population dynamics of Rift Valley fever virus mosquito vectors (Diptera, Culicidae) in Senegal. ( 29316967 )
2018
10
Peripheral Blood Biomarkers of Disease Outcome in a Monkey Model of Rift Valley Fever Encephalitis. ( 29118127 )
2018
11
Seroprevalence of Rift Valley Fever Virus Antibodies in Cattle in Mali, 2005-2014. ( 29363462 )
2018
12
Vector competence of Culex antennatus and Anopheles coustani mosquitoes for Rift Valley fever virus in Madagascar. ( 29383746 )
2018
13
Culex flavivirus infection in a Culex pipiens mosquito colony and its effects on vector competence for Rift Valley fever phlebovirus. ( 29792223 )
2018
14
Development of monoclonal antibodies to Rift Valley Fever Virus and their application in antigen detection and indirect immunofluorescence. ( 29894749 )
2018
15
Prevalence and risk factors of Rift Valley fever in humans and animals from Kabale district in Southwestern Uganda, 2016. ( 29723189 )
2018
16
Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates. ( 29742102 )
2018
17
Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters. ( 29864447 )
2018
18
Evaluation of Fluorescence Microsphere Immunoassay for Detection of Antibodies to Rift Valley Fever Virus Nucleocapsid Protein and Glycoproteins. ( 29563201 )
2018
19
Phosphoproteomic analysis reveals Smad protein family activation following Rift Valley fever virus infection. ( 29408900 )
2018
20
Serological evidence of rift valley fever Phlebovirus and Crimean-Congo hemorrhagic fever orthonairovirus infections among pygmies in the east region of Cameroon. ( 29625611 )
2018
21
Datasets for mapping pastoralist movement patterns and risk zones of Rift Valley fever occurrence. ( 29276743 )
2018
22
A Rift Valley fever virus Gn ectodomain-based DNA vaccine induces a partial protection not improved by APC targeting. ( 29707242 )
2018
23
Interspecific network centrality, host range and early-life development are associated with wildlife hosts of Rift Valley fever virus. ( 29756406 )
2018
24
Experimental transmission of West Nile Virus and Rift Valley Fever Virus by Culex pipiens from Lebanon. ( 29324834 )
2018
25
Correction: Phosphoproteomic analysis reveals Smad protein family activation following Rift Valley fever virus infection. ( 29543894 )
2018
26
Human Biomarkers of Outcome following Rift Valley fever virus Infection. ( 29955891 )
2018
27
Sero-prevalence and spatial distribution of Rift Valley fever infection among agro-pastoral and pastoral communities during Interepidemic period in the Serengeti ecosystem, northern Tanzania. ( 29898686 )
2018
28
Competence of mosquitoes native to the United Kingdom to support replication and transmission of Rift Valley fever virus. ( 29776384 )
2018
29
Rift Valley fever in animals and humans: Current perspectives. ( 29857007 )
2018
30
Understanding the legal trade of cattle and camels and the derived risk of Rift Valley Fever introduction into and transmission within Egypt. ( 29351273 )
2018
31
Genetic stability of Rift Valley fever virus MP-12 vaccine during serial passages in culture cells. ( 29167748 )
2017
32
Innate Immune Basis for Rift Valley Fever Susceptibility in Mouse Models. ( 28769107 )
2017
33
Phylogeography of Rift Valley Fever Virus in Africa and the Arabian Peninsula. ( 28068340 )
2017
34
Climate Influence on Emerging Risk Areas for Rift Valley Fever Epidemics in Tanzania. ( 28719317 )
2017
35
Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids. ( 29267287 )
2017
36
Spatial, seasonal and climatic predictive models of Rift Valley fever disease across Africa. ( 28584173 )
2017
37
An equine herpesvirus type 1 (EHV-1) vector expressing Rift Valley fever virus (RVFV) Gn and Gc induces neutralizing antibodies in sheep. ( 28807043 )
2017
38
The first serological evidence for Rift Valley fever infection in the camel, goitered gazelle and Anatolian water buffaloes in Turkey. ( 28861841 )
2017
39
Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain. ( 29061350 )
2017
40
Seroepidemiological Survey of Rift Valley Fever Virus in Ruminants in Garissa, Kenya. ( 27929928 )
2017
41
Distinct virulence of Rift Valley fever phlebovirus strains from different genetic lineages in a mouse model. ( 29267298 )
2017
42
Alterations in the host transcriptome in vitro following Rift Valley fever virus infection. ( 29085037 )
2017
43
Rift Valley fever virus and European mosquitoes: vector competence of Culex pipiens and Stegomyia albopicta (=a88Aedes albopictus). ( 28782121 )
2017
44
Recent advances in the development of antiviral therapeutics for Rift Valley fever virus infection. ( 29181086 )
2017
45
Risk analysis of inter-species reassortment through a Rift Valley fever phlebovirus MP-12 vaccine strain. ( 28926632 )
2017
46
The sero-epidemiology of Rift Valley fever in people in the Lake Victoria Basin of western Kenya. ( 28686589 )
2017
47
Overlapping CD8+ and CD4+ T-cell epitopes identification for the progression of epitope-based peptide vaccine from nucleocapsid and glycoprotein of emerging Rift Valley fever virus using immunoinformatics approach. ( 29107145 )
2017
48
Reconstruction of Rift Valley fever transmission dynamics in Madagascar: estimation of force of infection from seroprevalence surveys using Bayesian modelling. ( 28051125 )
2017
49
Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments. ( 28915104 )
2017
50
Drivers for Rift Valley fever emergence in Mayotte: A Bayesian modelling approach. ( 28732006 )
2017

Variations for Rift Valley Fever

Expression for Rift Valley Fever

Search GEO for disease gene expression data for Rift Valley Fever.

Pathways for Rift Valley Fever

Pathways related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.93 CD40LG PRKCE TP53
2
Show member pathways
10.72 PRKCE TP53
3 10.68 CD40LG CD83

GO Terms for Rift Valley Fever

Cellular components related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD209 CD40LG CD83

Biological processes related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type I interferon signaling pathway GO:0060337 9.37 IFITM3 MX1
2 positive regulation of T cell proliferation GO:0042102 9.32 CD209 CD40LG
3 nucleotide-excision repair GO:0006289 9.26 GTF2H1 TP53
4 negative regulation of viral genome replication GO:0045071 9.16 IFITM3 MX1
5 leukocyte cell-cell adhesion GO:0007159 8.96 CD209 CD40LG
6 positive regulation of interleukin-10 production GO:0032733 8.62 CD40LG CD83

Sources for Rift Valley Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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