MCID: RFT001
MIFTS: 50

Rift Valley Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Rift Valley Fever

MalaCards integrated aliases for Rift Valley Fever:

Name: Rift Valley Fever 12 73 58 54 3 44 15 70 32

Characteristics:

Orphanet epidemiological data:

58
rift valley fever
Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Rift Valley Fever

CDC : 3 Rift Valley fever (RVF) is an acute, fever-causing viral disease most commonly observed in domesticated animals (such as cattle, buffalo, sheep, goats, and camels), with the ability to infect and cause illness in humans. The disease is caused by RVF virus (RVFV), a member of the genus Phlebovirus in the family Bunyaviridae. It was first reported in livestock by veterinary officers in Kenya's Rift Valley in the early 1910s. RVF is generally found in regions of eastern and southern Africa where sheep and cattle are raised, but the virus exists in most of sub-Saharan Africa, including west Africa and Madagascar. In September 2000, a RVF outbreak was reported in Saudi Arabia and subsequently, Yemen. This outbreak represents the first cases of Rift Valley fever identified outside Africa. Outbreaks of RVF can have major societal impacts, including significant economic losses and trade reductions. The virus most commonly affects livestock, causing disease and abortion in domesticated animals, an important income source for many. Outbreaks of disease in animal populations are called "epizootics." The most notable RVF epizootic occurred in Kenya in 1950-1951, resulting in the death of an estimated 100,000 sheep. Additionally, epizootic outbreaks of RVF increase the likelihood of contact between diseased animals and humans, which can lead to epidemics of RVF in humans. One example occurred in 1977 when the virus was detected in Egypt (possibly imported from infected domestic animals from Sudan) and caused a large outbreak of RVF among both animals and humans resulting in over 600 human deaths. Another example of RVF spillover into human populations occurred in west Africa in 1987, and was linked to construction of the Senegal River Project. The project caused flooding in the lower Senegal River area, altering ecological conditions and interactions between animals and humans. As a result, a large RVF outbreak occurred in animals and humans.

MalaCards based summary : Rift Valley Fever is related to west nile virus and newcastle disease, and has symptoms including jaundice, menorrhagia and vomiting blood. An important gene associated with Rift Valley Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Cytokine Signaling in Immune system and 4-1BB Pathway. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include kidney, skin and eye, and related phenotypes are fatigue and fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Rift Valley fever virus, which is transmitted by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has symptom jaundice, has symptom vomiting blood, has symptom passing blood in the feces, has symptom ecchymoses (caused by bleeding in the skin), has symptom bleeding from the nose or gums, has symptom menorrhagia and has symptom bleeding from venepuncture sites.

Wikipedia : 73 Rift Valley fever (RVF) is a viral disease of humans and livestock that can cause mild to severe... more...

Related Diseases for Rift Valley Fever

Diseases related to Rift Valley Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 west nile virus 30.9 IFITM3 IFITM2 IFITM1 CD209
2 newcastle disease 30.6 TP53 EIF2S1 EIF2AK2
3 phlebotomus fever 30.3 SAP30 GTF2H2 GTF2H1
4 stomatitis 30.3 MX1 IFITM3 IFITM2 EIF2AK2
5 dengue virus 30.2 PABPC1 IFITM3 IFITM2 IFITM1 CD209
6 zika fever 30.1 IFNAR1 CD209
7 viral infectious disease 29.6 MX1 IFNAR1 EIF2S1 EIF2AK2 CD209
8 influenza 29.5 MX1 IFITM3 IFITM2 IFITM1 EIF2S1 EIF2AK2
9 coccidioidomycosis 11.7
10 encephalitis 10.9
11 neuroretinitis 10.8
12 retinitis 10.8
13 yemenite deaf-blind hypopigmentation syndrome 10.7
14 crimean-congo hemorrhagic fever 10.6
15 yellow fever 10.6
16 vaccinia 10.6
17 chikungunya 10.6
18 meningoencephalitis 10.6
19 triiodothyronine receptor auxiliary protein 10.5
20 disseminated intravascular coagulation 10.5
21 west nile encephalitis 10.5
22 west nile fever 10.5
23 viral hemorrhagic fever 10.5
24 disease by infectious agent 10.5
25 brucellosis 10.5
26 q fever 10.4
27 skin disease 10.4
28 plague 10.4
29 venezuelan equine encephalitis 10.4
30 arbovirosis 10.4
31 ataxia and polyneuropathy, adult-onset 10.3
32 japanese encephalitis 10.3
33 rabies 10.3
34 hepatorenal syndrome 10.3
35 hemorrhagic disease 10.3
36 mouth disease 10.3
37 lymphopenia 10.3
38 48,xyyy 10.3
39 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
40 ifap syndrome 2 10.2
41 uveitis 10.2
42 diarrhea 10.2
43 acute kidney failure 10.2
44 ebola hemorrhagic fever 10.2
45 avian influenza 10.2
46 hydranencephaly 10.2
47 poliomyelitis 10.2
48 iridocyclitis 10.2
49 lassa fever 10.2
50 cytokine deficiency 10.2

Graphical network of the top 20 diseases related to Rift Valley Fever:



Diseases related to Rift Valley Fever

Symptoms & Phenotypes for Rift Valley Fever

Human phenotypes related to Rift Valley Fever:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
4 hallucinations 58 31 frequent (33%) Frequent (79-30%) HP:0000738
5 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
6 vertigo 58 31 frequent (33%) Frequent (79-30%) HP:0002321
7 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
8 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
9 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
10 limitation of joint mobility 58 31 frequent (33%) Frequent (79-30%) HP:0001376
11 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
12 chemosis 58 31 frequent (33%) Frequent (79-30%) HP:0012375
13 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
14 retinopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000488
15 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
16 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
17 purpura 58 31 occasional (7.5%) Occasional (29-5%) HP:0000979
18 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
19 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
20 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
21 bruising susceptibility 58 31 occasional (7.5%) Occasional (29-5%) HP:0000978
22 hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001399
23 lethargy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001254
24 scotoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0000575
25 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
26 hemianopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0012377
27 visual loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0000572
28 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695
29 abnormal retinal artery morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0000630
30 seizure 31 occasional (7.5%) HP:0001250
31 seizures 58 Occasional (29-5%)
32 cholestasis 58 Occasional (29-5%)

Symptoms:

12
  • jaundice
  • menorrhagia
  • vomiting blood
  • passing blood in the feces
  • ecchymoses
  • bleeding from the nose
  • bleeding from venepuncture sites

GenomeRNAi Phenotypes related to Rift Valley Fever according to GeneCards Suite gene sharing:

26 (show all 40)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.02 EIF2AK2 PRKCE
2 Decreased viability GR00221-A-2 10.02 EIF2AK2 GTF2H1
3 Decreased viability GR00221-A-3 10.02 EIF2AK2
4 Decreased viability GR00221-A-4 10.02 EIF2AK2 GTF2H1 PRKCE
5 Decreased viability GR00240-S-1 10.02 SAP30 TP53
6 Decreased viability GR00249-S 10.02 DDX17 IFITM1 MX1 TP53
7 Decreased viability GR00301-A 10.02 EIF2AK2
8 Decreased viability GR00381-A-1 10.02 GTF2H2 IFITM1
9 Decreased viability GR00386-A-1 10.02 EIF2S1 IFNAR1 RNASEK
10 Decreased viability GR00402-S-2 10.02 EIF2S1 PABPC1 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.85 FBXO3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.85 GTF2H2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.85 SLC4A1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.85 TP53
15 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.85 TP53
16 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.85 GTF2H2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.85 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.85 FBXO3
19 Increased shRNA abundance (Z-score > 2) GR00366-A-142 9.85 FBXO3 GTF2H2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.85 FBXO3
21 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.85 GTF2H2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.85 TP53
23 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.85 FBXO3
24 Increased shRNA abundance (Z-score > 2) GR00366-A-184 9.85 TP53
25 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.85 FBXO3 SLC4A1 TP53
26 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.85 TP53
27 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.85 FBXO3
28 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.85 FBXO3
29 Increased shRNA abundance (Z-score > 2) GR00366-A-20 9.85 TP53
30 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.85 GTF2H2
31 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.85 FBXO3 GTF2H2
32 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.85 TP53
33 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.85 GTF2H2
34 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.85 TP53
35 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.85 FBXO3
36 Increased shRNA abundance (Z-score > 2) GR00366-A-62 9.85 TP53
37 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.85 GTF2H2
38 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.85 FBXO3
39 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.85 SLC4A1
40 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.85 SLC4A1

Drugs & Therapeutics for Rift Valley Fever

Drugs for Rift Valley Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parts A&B: Evaluation of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200), A Phase 2 Study Completed NCT00584194 Phase 2
2 Safety and Immunogenicity of Live-Attenuated MP-12 Rift Valley Fever Vaccine in Humans, and Genetic Characterization of Virus Isolates Recovered From the Blood of Vaccinated Volunteers: A Phase II Study Completed NCT00415051 Phase 2
3 A Phase 2 Open Label Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated, Dried, TSI-GSD 200, Lot 7, Run 2, in Adult Subjects at Risk of Exposure to Rift Valley Fever Virus Recruiting NCT03609398 Phase 2
4 Long-Term Open-Label Primary Vaccination and Booster Dose Study of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200) in At-Risk Adults Active, not recruiting NCT00869713 Phase 2
5 A Phase I Study to Determine the Safety and Immunogenicity of the Candidate Rift Valley Fever Virus (RVFV) Vaccine ChAdOx1 RVF Among Healthy Adult Volunteers in Uganda Not yet recruiting NCT04672824 Phase 1
6 Late Outcomes of Rift Valley Fever in Kenya: Ijara Clinical Survey Completed NCT00287014
7 A Phase I Study to Determine the Safety & Immunogenicity of the Candidate Rift Valley Fever Virus (RVFV) Vaccine ChAdOx1 RVF in UK Healthy Adult Volunteers Not yet recruiting NCT04754776 Early Phase 1

Search NIH Clinical Center for Rift Valley Fever

Cochrane evidence based reviews: rift valley fever

Genetic Tests for Rift Valley Fever

Anatomical Context for Rift Valley Fever

MalaCards organs/tissues related to Rift Valley Fever:

40
Kidney, Skin, Eye, Testis, T Cells, Bone Marrow, Whole Blood

Publications for Rift Valley Fever

Articles related to Rift Valley Fever:

(show top 50) (show all 1980)
# Title Authors PMID Year
1
The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirus. 54 61
17970694 2007
2
Ocular manifestations of emerging viral diseases. 61
33514902 2021
3
A comprehensive review on the antiviral activities of chalcones. 61
33232192 2021
4
A serological and hematological study on Rift valley fever and associated risk factors in aborted sheep at Kurdistan province in west of Iran. 61
33609990 2021
5
Farmers' preference and willingness to pay for a multivalent lumpy skin disease and Rift Valley fever novel vaccine: A discrete choice experiment in the Free State province, South Africa. 61
33631510 2021
6
Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition. 61
33782133 2021
7
Black rats (Rattus rattus) as potential reservoir hosts for Rift Valley fever phlebovirus: experimental infection results in viral replication and shedding without clinical manifestation. 61
33794070 2021
8
Visualizing the ribonucleoprotein content of single bunyavirus virions reveals more efficient genome packaging in the arthropod host. 61
33753850 2021
9
Laboratory demonstration of the vertical transmission of Rift Valley fever virus by Culex tarsalis mosquitoes. 61
33750981 2021
10
Vaccine Efficacy of Self-Assembled Multimeric Protein Scaffold Particles Displaying the Glycoprotein Gn Head Domain of Rift Valley Fever Virus. 61
33806789 2021
11
The role of livestock movements in the spread of Rift Valley fever virus in animals and humans in Mayotte, 2018-19. 61
33684126 2021
12
Myeloid-like γδ T cell subset in the immune response to an experimental Rift Valley fever vaccine in sheep. 61
33454621 2021
13
The Change P82L in the Rift Valley Fever Virus NSs Protein Confers Attenuation in Mice. 61
33805122 2021
14
Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya. 61
33770095 2021
15
A Review on Emerging Infectious Diseases Prioritized Under the 2018 WHO Research and Development Blueprint: Lessons from the Indian Context. 61
33316200 2021
16
[Biological characteristics and permissiveness to viruses of diploid kidney cells strain from the bat Nathusius' pipistrelle (Pipistrellus nathusii Keyserling & Blasius, 1839; Chiroptera: Microchiroptera: Vespertilionidae)]. 61
33683063 2021
17
Sero-surveillance of emerging viral diseases in camels and cattle in Nouakchott, Mauritania: an abattoir study. 61
33666802 2021
18
Surveillance of the major pathogenic arboviruses of public health concern in Gabon, Central Africa: increased risk of West Nile virus and dengue virus infections. 61
33731022 2021
19
Next-generation diagnostics: virus capture facilitates a sensitive viral diagnosis for epizootic and zoonotic pathogens including SARS-CoV-2. 61
33610182 2021
20
The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing. 61
33652597 2021
21
First Detection of the West Nile Virus Koutango Lineage in Sandflies in Niger. 61
33668365 2021
22
The ring finger protein 213 gene (Rnf213) contributes to Rift Valley fever resistance in mice. 61
33420513 2021
23
Rift Valley fever: a threat to pregnant women hiding in plain sight? 61
33597209 2021
24
Epidemiology and serological detection of Rift Valley Fever disease in farm animals in southern Egypt. 61
33567844 2021
25
Production of small ruminant morbillivirus, rift valley fever virus and lumpy skin disease virus in CelCradle™ -500A bioreactors. 61
33639955 2021
26
Development of Rift valley fever encephalitis in rats is mediated by early infection of olfactory epithelium and neuroinvasion across the cribriform plate. 61
33231535 2021
27
Indigenous knowledge of Rift Valley Fever among Somali nomadic pastoralists and its implications on public health delivery approaches in Ijara sub-County, North Eastern Kenya. 61
33617555 2021
28
Plant nutrient quality impacts survival and reproductive fitness of the dengue vector Aedes aegypti. 61
33397448 2021
29
ANTIBODY PREVALENCE TO AFRICAN SWINE FEVER VIRUS, MYCOBACTERIUM BOVIS, FOOT-AND-MOUTH DISEASE VIRUS, RIFT VALLEY FEVER VIRUS, INFLUENZA A VIRUS, AND BRUCELLA AND LEPTOSPIRA SPP. IN FREE-RANGING WARTHOG (PHACOCHOERUS AFRICANUS) POPULATIONS IN SOUTH AFRICA. 61
33635986 2021
30
In Vitro Evaluation of Anti-Rift Valley Fever Virus, Antioxidant and Anti-Inflammatory Activity of South African Medicinal Plant Extracts. 61
33572659 2021
31
Correction: Reanalysis of the 2000 Rift Valley fever outbreak in Southwestern Arabia. 61
33684149 2021
32
Retrospective phylogenetic analyses of formalin-fixed paraffin-embedded samples from the 2011 Rift Valley fever outbreak in South Africa, through sequencing of targeted regions. 61
33164863 2021
33
Reproducing the Rift Valley fever virus mosquito-lamb-mosquito transmission cycle. 61
33446733 2021
34
A single vaccination with four-segmented rift valley fever virus prevents vertical transmission of the wild-type virus in pregnant ewes. 61
33420095 2021
35
Rift Valley Fever and Crimean-Congo Hemorrhagic Fever Viruses in Ruminants, Jordan. 61
33496248 2021
36
Sero-prevalence of brucellosis, Q-fever and Rift Valley fever in humans and livestock in Somali Region, Ethiopia. 61
33493173 2021
37
Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases. 61
33692745 2021
38
Sero-prevalence of West Nile virus and Rift Valley fever virus infections among cattle under extensive production system in South Omo area, southern Ethiopia. 61
33415465 2021
39
Development of a Simian RNA Polymerase I Promoter-Driven Reverse Genetics for the Rescue of Recombinant Rift Valley Fever Virus from Vero Cells. 61
33441343 2021
40
It's risky to wander in September: Modelling the epidemic potential of Rift Valley fever in a Sahelian setting. 61
33137548 2020
41
Safety and immunogenicity of the Rift Valley fever arMP-12 ΔNSm21/384 candidate vaccine in pregnant ewes. 61
32793877 2020
42
Operationalizing the One Health Approach in Uganda: Challenges and Opportunities. 61
33009732 2020
43
Alteration in the Culex pipiens transcriptome reveals diverse mechanisms of the mosquito immune system implicated upon Rift Valley fever phlebovirus exposure. 61
33301456 2020
44
Evaluation of public and animal health risks in case of a delayed post-mortem inspection in ungulates. 61
33304413 2020
45
The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion. 61
33087469 2020
46
Unique Outbreak of Rift Valley Fever in Sudan, 2019. 61
33219787 2020
47
Recombinant Rift Valley fever viruses encoding bluetongue virus (BTV) antigens: Immunity and efficacy studies upon a BTV-4 challenge. 61
33275608 2020
48
Human DDX17 Unwinds Rift Valley Fever Virus Non-Coding RNAs. 61
33374561 2020
49
Genetic Diversity of Rift Valley Fever Strains Circulating in Namibia in 2010 and 2011. 61
33339456 2020
50
Large herbivore loss has complex effects on mosquito ecology and vector-borne disease risk. 61
33170555 2020

Variations for Rift Valley Fever

Expression for Rift Valley Fever

Search GEO for disease gene expression data for Rift Valley Fever.

Pathways for Rift Valley Fever

Pathways related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 TP53 MX1 IFNAR1 IFITM3 IFITM2 IFITM1
2
Show member pathways
12.33 TP53 PRKCE EIF2S1 EIF2AK2
3
Show member pathways
12.21 TP53 SAP30 MX1 IFNAR1 EIF2S1 EIF2AK2
4
Show member pathways
12.12 MX1 IFNAR1 IFITM3 IFITM2 IFITM1 EIF2AK2
5 11.98 TP53 GTF2H2 GTF2H1 EIF2AK2
6
Show member pathways
11.38 TP53 PRKCE MX1 IFNAR1 IFITM3 IFITM2
7
Show member pathways
11.28 PABPC1 EIF2S1 EIF2AK2
8
Show member pathways
10.79 MX1 IFNAR1 EIF2AK2

GO Terms for Rift Valley Fever

Cellular components related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.03 TP53 SLC4A1 RNASEK PRKCE PABPC1 MX1
2 transcription factor TFIIH holo complex GO:0005675 8.96 GTF2H2 GTF2H1
3 transcription factor TFIIH core complex GO:0000439 8.62 GTF2H2 GTF2H1

Biological processes related to Rift Valley Fever according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.97 PRKCE MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
2 innate immune response GO:0045087 9.95 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2 CD209
3 defense response to virus GO:0051607 9.8 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2 DDX17
4 nucleotide-excision repair GO:0006289 9.67 TP53 GTF2H2 GTF2H1
5 type I interferon signaling pathway GO:0060337 9.65 MX1 IFNAR1 IFITM3 IFITM2 IFITM1
6 response to interferon-gamma GO:0034341 9.63 IFITM3 IFITM2 IFITM1
7 response to virus GO:0009615 9.63 MX1 IFNAR1 IFITM3 IFITM2 IFITM1 EIF2AK2
8 negative regulation of viral entry into host cell GO:0046597 9.61 IFITM3 IFITM2 IFITM1
9 response to interferon-beta GO:0035456 9.58 IFITM3 IFITM2 IFITM1
10 nucleotide-excision repair, DNA duplex unwinding GO:0000717 9.54 GTF2H2 GTF2H1
11 nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006295 9.52 GTF2H2 GTF2H1
12 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.51 GTF2H2 GTF2H1
13 negative regulation of viral genome replication GO:0045071 9.35 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
14 response to interferon-alpha GO:0035455 8.92 IFITM3 IFITM2 IFITM1 EIF2AK2

Molecular functions related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.58 TP53 SLC4A1 SAP30 RNASEK PRKCE PABPC1

Sources for Rift Valley Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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