MCID: RFT001
MIFTS: 47

Rift Valley Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Rift Valley Fever

MalaCards integrated aliases for Rift Valley Fever:

Name: Rift Valley Fever 12 74 58 54 3 43 15 71 32

Characteristics:

Orphanet epidemiological data:

58
rift valley fever
Prevalence: <1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


Summaries for Rift Valley Fever

CDC : 3 Rift Valley fever (RVF) is an acute, fever-causing viral disease most commonly observed in domesticated animals (such as cattle, buffalo, sheep, goats, and camels), with the ability to infect and cause illness in humans. The disease is caused by RVF virus (RVFV), a member of the genus Phlebovirus in the family Bunyaviridae. It was first reported in livestock by veterinary officers in Kenya's Rift Valley in the early 1910s. RVF is generally found in regions of eastern and southern Africa where sheep and cattle are raised, but the virus exists in most of sub-Saharan Africa, including west Africa and Madagascar. In September 2000, a RVF outbreak was reported in Saudi Arabia and subsequently, Yemen. This outbreak represents the first cases of Rift Valley fever identified outside Africa. Outbreaks of RVF can have major societal impacts, including significant economic losses and trade reductions. The virus most commonly affects livestock, causing disease and abortion in domesticated animals, an important income source for many. Outbreaks of disease in animal populations are called "epizootics." The most notable RVF epizootic occurred in Kenya in 1950-1951, resulting in the death of an estimated 100,000 sheep. Additionally, epizootic outbreaks of RVF increase the likelihood of contact between diseased animals and humans, which can lead to epidemics of RVF in humans. One example occurred in 1977 when the virus was detected in Egypt (possibly imported from infected domestic animals from Sudan) and caused a large outbreak of RVF among both animals and humans resulting in over 600 human deaths. Another example of RVF spillover into human populations occurred in west Africa in 1987, and was linked to construction of the Senegal River Project. The project caused flooding in the lower Senegal River area, altering ecological conditions and interactions between animals and humans. As a result, a large RVF outbreak occurred in animals and humans.

MalaCards based summary : Rift Valley Fever is related to west nile virus and dengue virus, and has symptoms including jaundice, menorrhagia and vomiting blood. An important gene associated with Rift Valley Fever is CD209 (CD209 Molecule), and among its related pathways/superpathways are Cytokine Signaling in Immune system and 4-1BB Pathway. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and brain, and related phenotypes are fatigue and fever

Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in Rift Valley fever virus, which is transmitted by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has symptom jaundice, has symptom vomiting blood, has symptom passing blood in the feces, has symptom ecchymoses (caused by bleeding in the skin), has symptom bleeding from the nose or gums, has symptom menorrhagia and has symptom bleeding from venepuncture sites.

Wikipedia : 74 Rift Valley fever (RVF) is a viral disease that can cause mild to severe symptoms. The mild symptoms may... more...

Related Diseases for Rift Valley Fever

Diseases related to Rift Valley Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 west nile virus 31.0 IFITM3 IFITM2 IFITM1 CD209
2 dengue virus 30.6 IFITM3 IFITM2 IFITM1 CD209
3 phlebotomus fever 30.5 SAP30 GTF2H1 CD40LG
4 west nile fever 30.1 PRNT CD40LG CD209
5 stomatitis 29.9 MX1 IFITM3 IFITM2 EIF2AK2 CD40LG
6 viral infectious disease 29.6 MX1 EIF2S1 EIF2AK2 CD40LG CD209
7 st. louis encephalitis 29.6 PRNT CD40LG
8 coccidioidomycosis 11.7
9 encephalitis 10.9
10 neuroretinitis 10.8
11 retinitis 10.8
12 yemenite deaf-blind hypopigmentation syndrome 10.8
13 crimean-congo hemorrhagic fever 10.7
14 yellow fever 10.7
15 chikungunya 10.6
16 meningoencephalitis 10.6
17 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.6
18 vaccinia 10.6
19 disseminated intravascular coagulation 10.5
20 diarrhea 10.5
21 viral hemorrhagic fever 10.5
22 triiodothyronine receptor auxiliary protein 10.5
23 west nile encephalitis 10.5
24 brucellosis 10.4
25 newcastle disease 10.4
26 plague 10.4
27 venezuelan equine encephalitis 10.4
28 arbovirosis 10.4
29 japanese encephalitis 10.4
30 q fever 10.4
31 rabies 10.4
32 hepatorenal syndrome 10.4
33 neutropenia 10.4
34 48,xyyy 10.4
35 ataxia and polyneuropathy, adult-onset 10.3
36 uveitis 10.3
37 acute kidney failure 10.3
38 skin disease 10.3
39 ebola hemorrhagic fever 10.3
40 avian influenza 10.3
41 hydranencephaly 10.3
42 poliomyelitis 10.3
43 lymphopenia 10.3
44 vasculitis 10.3
45 iridocyclitis 10.3
46 lassa fever 10.3
47 choroid cancer 10.2 IFITM2 GTF2H1
48 renal cell carcinoma, nonpapillary 10.1
49 immunoglobulin switch sequences 10.1
50 antigen defined by monoclonal antibody aj9 10.1

Graphical network of the top 20 diseases related to Rift Valley Fever:



Diseases related to Rift Valley Fever

Symptoms & Phenotypes for Rift Valley Fever

Human phenotypes related to Rift Valley Fever:

58 31 (show all 32)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
3 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002017
4 hallucinations 58 31 frequent (33%) Frequent (79-30%) HP:0000738
5 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
6 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
7 limitation of joint mobility 58 31 frequent (33%) Frequent (79-30%) HP:0001376
8 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
9 chemosis 58 31 frequent (33%) Frequent (79-30%) HP:0012375
10 vertigo 58 31 frequent (33%) Frequent (79-30%) HP:0002321
11 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
12 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
13 seizures 58 31 occasional (7.5%) Occasional (29-5%) HP:0001250
14 encephalitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002383
15 retinopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000488
16 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
17 gastrointestinal hemorrhage 58 31 occasional (7.5%) Occasional (29-5%) HP:0002239
18 jaundice 58 31 occasional (7.5%) Occasional (29-5%) HP:0000952
19 anorexia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002039
20 hemianopia 58 31 occasional (7.5%) Occasional (29-5%) HP:0012377
21 visual loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0000572
22 hepatic failure 58 31 occasional (7.5%) Occasional (29-5%) HP:0001399
23 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
24 purpura 58 31 occasional (7.5%) Occasional (29-5%) HP:0000979
25 meningitis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001287
26 bruising susceptibility 58 31 occasional (7.5%) Occasional (29-5%) HP:0000978
27 lethargy 58 31 occasional (7.5%) Occasional (29-5%) HP:0001254
28 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695
29 scotoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0000575
30 abnormal retinal artery morphology 31 occasional (7.5%) HP:0000630
31 cholestasis 58 Occasional (29-5%)
32 abnormality of retinal arteries 58 Occasional (29-5%)

Symptoms:

12
  • jaundice
  • menorrhagia
  • vomiting blood
  • passing blood in the feces
  • ecchymoses
  • bleeding from the nose
  • bleeding from venepuncture sites

Drugs & Therapeutics for Rift Valley Fever

Drugs for Rift Valley Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Parts A&B: Evaluation of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200), A Phase 2 Study Completed NCT00584194 Phase 2
2 Safety and Immunogenicity of Live-Attenuated MP-12 Rift Valley Fever Vaccine in Humans, and Genetic Characterization of Virus Isolates Recovered From the Blood of Vaccinated Volunteers: A Phase II Study Completed NCT00415051 Phase 2
3 A Phase 2 Open Label Safety and Immunogenicity Study of Rift Valley Fever Vaccine, Inactivated, Dried, TSI-GSD 200, Lot 7, Run 2, in Adult Subjects at Risk of Exposure to Rift Valley Fever Virus Recruiting NCT03609398 Phase 2
4 Long-Term Open-Label Primary Vaccination and Booster Dose Study of the Safety and Immunogenicity of Rift Valley Fever Vaccine, Inactivated, Dried (TSI-GSD 200) in At-Risk Adults Active, not recruiting NCT00869713 Phase 2
5 Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Completed NCT03055000 Phase 1
6 Late Outcomes of Rift Valley Fever in Kenya: Ijara Clinical Survey Completed NCT00287014

Search NIH Clinical Center for Rift Valley Fever

Cochrane evidence based reviews: rift valley fever

Genetic Tests for Rift Valley Fever

Anatomical Context for Rift Valley Fever

MalaCards organs/tissues related to Rift Valley Fever:

40
Liver, Skin, Brain, Kidney, Testes, T Cells, Monocytes

Publications for Rift Valley Fever

Articles related to Rift Valley Fever:

(show top 50) (show all 1832)
# Title Authors PMID Year
1
The antiviral potential of interferon-induced cotton rat Mx proteins against orthomyxovirus (influenza), rhabdovirus, and bunyavirus. 54 61
17970694 2007
2
Methods for successful inactivation of Rift Valley fever virus in infected mosquitoes. 61
31794780 2020
3
Effect of Environmental Temperature on the Ability of Culex tarsalis and Aedes taeniorhynchus (Diptera: Culicidae) to Transmit Rift Valley Fever Virus. 61
32017863 2020
4
Rift Valley fever virus targets the maternal-foetal interface in ovine and human placentas. 61
31961862 2020
5
Lesions and Cellular Tropism of Natural Rift Valley Fever Virus Infection in Young Lambs. 61
31842723 2020
6
Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine. 61
31910225 2020
7
Developing vaccines against epidemic-prone emerging infectious diseases. 61
31776599 2020
8
Finding equipoise: CEPI revises its equitable access policy. 61
32005536 2020
9
Lyophilized Matrix Containing Ready-to-Use Primers and Probe Solution for Standardization of Real-Time PCR and RT-qPCR Diagnostics in Virology. 61
32019076 2020
10
Elongin C contributes to RNA polymerase II degradation by the interferon antagonist NSs of La Crosse orthobunyavirus. 61
31941775 2020
11
The use of mice lacking type I or both type I and type II interferon responses in research on hemorrhagic fever viruses. Part 2: Vaccine efficacy studies. 61
31982149 2020
12
Relative Distribution, Diversity, and Bloodmeal Sources of Mosquitoes and Known Vectors of Rift Valley Fever Phlebovirus in Three Differing Ecosystems in Bura, Tana River County, Kenya. 61
31990632 2020
13
Neutralizing antibodies against Rift Valley fever virus in wild antelope in far northern KwaZulu-Natal, South Africa, indicate recent virus circulation. 61
31943795 2020
14
Zwiesel bat banyangvirus, a potentially zoonotic Huaiyangshan banyangvirus (Formerly known as SFTS)-like banyangvirus in Northern bats from Germany. 61
31992832 2020
15
The challenging management of Rift Valley Fever in humans: literature review of the clinical disease and algorithm proposal. 61
31969141 2020
16
Microencapsulated plasmids expressing Gn and Gc glycoproteins of Rift Valley Fever virus enhance humoral immune response in mice. 61
31983039 2020
17
A comment on 'Seroprevalence of Rift Valley fever in South African domestic and wild suids (1999-2016)'. 61
31898395 2020
18
Rift Valley Fever Virus: Propagation, Quantification, and Storage. 61
31763765 2019
19
Mechanisms of inter-epidemic maintenance of Rift Valley fever phlebovirus. 61
31870761 2019
20
Candidate vaccines for human Rift Valley fever. 61
31478397 2019
21
Prevalence and identification of arthropod-transmitted viruses in Kassala state, Eastern Sudan. 61
30716013 2019
22
Common vole (Microtus arvalis) and bank vole (Myodes glareolus) derived permanent cell lines differ in their susceptibility and replication kinetics of animal and zoonotic viruses. 61
31513859 2019
23
Health of African Buffalos (Syncerus caffer) in Ruaha National Park, Tanzania. 61
31833815 2019
24
Sero-Epidemiological Study of Selected Zoonotic and Abortifacient Pathogens in Cattle at a Wildlife-Livestock Interface in South Africa. 61
31841655 2019
25
CEPI: Driving Progress Towards Epidemic Preparedness And Response. 61
31673694 2019
26
Structure and function of the Toscana virus cap-snatching endonuclease. 61
31584100 2019
27
Simian adenovirus vector production for early-phase clinical trials: A simple method applicable to multiple serotypes and using entirely disposable product-contact components. 61
31047679 2019
28
Willingness to pay for a Rift valley fever (RVF) vaccine among Kenyan cattle producers. 61
31525647 2019
29
Rescue of infectious Arumowot virus from cloned cDNA: Posttranslational degradation of Arumowot virus NSs protein in human cells. 61
31751340 2019
30
Development of Rift Valley fever (RVF) vaccine by genetic joining of the RVF-glycoprotein Gn with the strong adjuvant subunit B of cholera toxin (CTB) and expression in bacterial system. 61
31762643 2019
31
Antiviral and virucidal activities of Lucilia cuprina maggots' excretion/secretion (Diptera: Calliphoridae): first work. 61
31844722 2019
32
Seroprevalence of Rift Valley fever in cattle of smallholder farmers in Kwilu Province in the Democratic Republic of Congo. 61
31250252 2019
33
Seroprevalence of Rift valley fever in South African domestic and wild suids (1999-2016). 61
31655018 2019
34
Rift Valley fever virus in small ruminants in the Democratic Republic of the Congo. 61
31714136 2019
35
Genetically Modified Rabies Virus Vector-Based Rift Valley Fever Virus Vaccine is Safe and Induces Efficacious Immune Responses in Mice. 61
31597372 2019
36
Health risk assessment at mass gatherings: a report of the camel festival in Saudi Arabia. 61
31625590 2019
37
Genomic Characterization of Rift Valley Fever Virus, South Africa, 2018. 61
31538932 2019
38
TRIM69 Inhibits Vesicular Stomatitis Indiana Virus. 61
31375575 2019
39
Nuclear pore protein Nup98 is involved in replication of Rift Valley fever virus and nuclear import of virulence factor NSs. 61
31671053 2019
40
Field-captured Aedes vexans (Meigen, 1830) is a competent vector for Rift Valley fever phlebovirus in Europe. 61
31619269 2019
41
Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine. 61
31635418 2019
42
A strand-specific real-time quantitative RT-PCR assay for distinguishing the genomic and antigenomic RNAs of Rift Valley fever phlebovirus. 61
31315022 2019
43
Evaluation of an Indirect Enzyme-Linked Immunosorbent Assay Based on Recombinant Baculovirus-Expressed Rift Valley Fever Virus Nucleoprotein as the Diagnostic Antigen. 61
31366690 2019
44
Development and validation of a pen side test for Rift Valley fever. 61
31509527 2019
45
Mobile phone-based surveillance for animal disease in rural communities: implications for detection of zoonoses spillover. 61
31401960 2019
46
NSs Filament Formation Is Important but Not Sufficient for RVFV Virulence In Vivo. 61
31500343 2019
47
Current status and evolving approaches to African swine fever vaccine development. 61
31538406 2019
48
Schlafen 11 Restricts Flavivirus Replication. 61
31118262 2019
49
Lethal Mutagenesis of Rift Valley Fever Virus Induced by Favipiravir. 61
31085519 2019
50
Rift Valley fever: biology and epidemiology. 61
31310198 2019

Variations for Rift Valley Fever

Expression for Rift Valley Fever

Search GEO for disease gene expression data for Rift Valley Fever.

Pathways for Rift Valley Fever

Pathways related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.02 TP53 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
2
Show member pathways
12.25 TP53 PRKCE EIF2S1 EIF2AK2 CD40LG
3
Show member pathways
12.14 TP53 SAP30 MX1 EIF2S1 EIF2AK2 CD209
4
Show member pathways
12.05 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
5
Show member pathways
11.31 TP53 PRKCE MX1 IFITM3 IFITM2 IFITM1
6
Show member pathways
11.28 PABPC1 EIF2S1 EIF2AK2

GO Terms for Rift Valley Fever

Cellular components related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.5 TP53 SLC4A1 RNASEK PRKCE PABPC1 MX1

Biological processes related to Rift Valley Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.95 PRKCE MX1 IFITM1 EIF2AK2 DDX17 CD209
2 innate immune response GO:0045087 9.93 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2 CD209
3 type I interferon signaling pathway GO:0060337 9.67 MX1 IFITM3 IFITM2 IFITM1
4 response to virus GO:0009615 9.65 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
5 defense response to virus GO:0051607 9.63 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2 DDX17
6 response to interferon-gamma GO:0034341 9.61 IFITM3 IFITM2 IFITM1
7 negative regulation of viral entry into host cell GO:0046597 9.58 IFITM3 IFITM2 IFITM1
8 response to interferon-beta GO:0035456 9.5 IFITM3 IFITM2 IFITM1
9 negative regulation of viral genome replication GO:0045071 9.35 MX1 IFITM3 IFITM2 IFITM1 EIF2AK2
10 response to interferon-alpha GO:0035455 8.92 IFITM3 IFITM2 IFITM1 EIF2AK2

Sources for Rift Valley Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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