MCID: RGH001
MIFTS: 45

Right Bundle Branch Block

Categories: Cardiovascular diseases

Aliases & Classifications for Right Bundle Branch Block

MalaCards integrated aliases for Right Bundle Branch Block:

Name: Right Bundle Branch Block 12 29 55 6 15 73
Right Bundle Branch Block with Left Posterior Fascicular Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13209
ICD9CM 35 426.51
SNOMED-CT 68 46319007

Summaries for Right Bundle Branch Block

MalaCards based summary : Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to ventricular fibrillation, paroxysmal familial, 1 and brugada syndrome 2. An important gene associated with Right Bundle Branch Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Developmental Biology. The drugs Lithium carbonate and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and testes, and related phenotypes are cardiovascular system and nervous system

Wikipedia : 76 A right bundle branch block (RBBB) is a heart block in the right bundle branch of the electrical... more...

Related Diseases for Right Bundle Branch Block

Diseases related to Right Bundle Branch Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 ventricular fibrillation, paroxysmal familial, 1 32.7 CACNA1C SCN5A
2 brugada syndrome 2 32.3 GPD1L SCN5A
3 brugada syndrome 5 32.2 SCN1B SCN5A
4 brugada syndrome 31.0 CACNA1C CACNB2 GPD1L HCN4 KCND3 SCN1B
5 atrioventricular block 30.7 HCN4 SCN5A TRPM4
6 heart disease 30.4 BMPR2 CACNA1C HCN4 SCN5A
7 sinoatrial node disease 30.2 HCN4 SCN5A
8 atrial fibrillation 30.1 HCN4 SCN1B SCN2B SCN3B SCN5A
9 long qt syndrome 28.8 CACNA1C CACNB2 GPD1L HCN4 KCND3 SCN1B
10 progressive familial heart block, type ib 12.5
11 progressive familial heart block, type ia 12.1
12 brugada syndrome 1 12.1
13 brugada syndrome 3 11.4
14 brugada syndrome 4 11.4
15 brugada syndrome 6 11.4
16 brugada syndrome 7 11.4
17 brugada syndrome 8 11.4
18 brugada syndrome 9 11.4
19 myocardial infarction 11.0
20 acute myocardial infarction 10.8
21 tetralogy of fallot 10.6
22 atrial standstill 1 10.5
23 ventricular septal defect 10.5
24 arrhythmogenic right ventricular cardiomyopathy 10.4
25 left bundle branch hemiblock 10.4
26 pulmonary embolism 10.4
27 cardiac conduction defect 10.4
28 wolff-parkinson-white syndrome 10.4
29 ischemia 10.4
30 congestive heart failure 10.4
31 atrial heart septal defect 10.4
32 inferior myocardial infarction 10.3
33 arteries, anomalies of 10.3
34 coronary artery anomaly 10.3
35 second-degree atrioventricular block 10.3
36 anteroseptal myocardial infarction 10.3
37 hypertrophic cardiomyopathy 10.3
38 atrial septal aneurysm 10.3
39 facioscapulohumeral muscular dystrophy 1 10.2
40 rheumatoid arthritis 10.2
41 scleroderma, familial progressive 10.2
42 arthritis 10.2
43 rheumatic heart disease 10.2
44 chagas disease 10.2
45 dextrocardia 10.2
46 muscular dystrophy 10.2
47 syncope 10.2
48 familial sick sinus syndrome 10.1 HCN4 SCN5A
49 third-degree atrioventricular block 10.1 HCN4 SCN5A
50 long qt syndrome 9 10.1 HCN4 SCN5A

Comorbidity relations with Right Bundle Branch Block via Phenotypic Disease Network (PDN): (show all 29)


Acute Cystitis Aortic Valve Disease 1
Atrioventricular Block Benign Essential Hypertension
Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Left Bundle Branch Hemiblock Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Prostatic Hypertrophy Pulmonary Hypertension, Primary, 1
Respiratory Failure Sinoatrial Node Disease
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to Right Bundle Branch Block

Symptoms & Phenotypes for Right Bundle Branch Block

MGI Mouse Phenotypes related to Right Bundle Branch Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 BMPR2 CACNA1C CACNB2 HCN4 KCND3 SCN3B
2 nervous system MP:0003631 9.17 BMPR2 CACNA1C CACNB2 HCN4 SCN1B SCN2B

Drugs & Therapeutics for Right Bundle Branch Block

Drugs for Right Bundle Branch Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 103)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lithium carbonate Approved Phase 4 554-13-2
2
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
3
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
4
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
5 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Not Applicable
6 Psychotropic Drugs Phase 4,Phase 3
7 GABA Agents Phase 4
8 Neurotransmitter Agents Phase 4,Phase 2
9 Anticonvulsants Phase 4,Phase 2
10 Antimanic Agents Phase 4
11 Tranquilizing Agents Phase 4,Phase 3
12 Antipsychotic Agents Phase 4,Phase 3
13 Antidepressive Agents Phase 4
14 Diuretics, Potassium Sparing Phase 4
15 Excitatory Amino Acid Antagonists Phase 4
16 Sodium Channel Blockers Phase 4
17 Excitatory Amino Acids Phase 4
18 Calcium, Dietary Phase 4
19 calcium channel blockers Phase 4
20
Tolvaptan Approved Phase 3 150683-30-0 216237
21
rituximab Approved Phase 3 174722-31-7 10201696
22 Antiprotozoal Agents Phase 3,Phase 2
23 Antiparasitic Agents Phase 3,Phase 2
24 Anti-Infective Agents Phase 3,Phase 2,Phase 1
25 Vasopressins Phase 3
26 Natriuretic Agents Phase 3
27 Arginine Vasopressin Phase 3
28 Hormones Phase 3
29 Benzonidazole Phase 3
30 Immunologic Factors Phase 3
31 Immunosuppressive Agents Phase 3
32 Antirheumatic Agents Phase 3
33 Bendamustine Hydrochloride Phase 3
34 Alkylating Agents Phase 3
35 Antineoplastic Agents, Alkylating Phase 3
36
Pyrimethamine Approved, Investigational, Vet_approved Phase 2 58-14-0 4993
37
leucovorin Approved Phase 2 58-05-9 6006 143
38
Sulfadoxine Approved, Investigational Phase 2 2447-57-6 17134
39
Ipratropium Approved Phase 2 60205-81-4, 22254-24-6 43232
40
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
41
Piperaquine Experimental, Investigational Phase 2 4085-31-8 5079497
42
Dihydroartemisinin Experimental, Investigational Phase 2 71939-50-9 6918483
43 Folate Phase 2
44 Anti-Infective Agents, Urinary Phase 2
45 Vitamin B9 Phase 2
46 Vitamin B Complex Phase 2
47 Artemisinine Phase 2
48 Fanasil, pyrimethamine drug combination Phase 2
49 Folic Acid Antagonists Phase 2
50 Antimalarials Phase 2

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania Completed NCT00261443 Phase 4 Lithium or Valproate with placebo (PBO);Lithium or Valproate with Aripiprazole
2 A Phase IV Study of the Safety and Efficacy of Aripiprazole in Combination With Lamotrigine in the Long-Term Maintenance Treatment of Patients With Bipolar I Disorder With A Recent Manic or Mixed Episode Completed NCT00277212 Phase 4 Lamotrigine + Aripiprazole;Lamotrigine + Placebo
3 Effects of Titrated Oral Tolvaptan 15-60 mg Once Daily (QD) on Cognitive and Neurological Function in Elderly Hyponatremic Patients Completed NCT00550459 Phase 3 Tolvaptan;Placebo
4 Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Clinical Trial Completed NCT02386358 Phase 3 Benznidazole;Placebo
5 Aripiprazole for Schizophrenia Outpatients Completing BMS Clinical Trials Completed NCT00239356 Phase 3 Aripiprazole
6 Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Completed NCT01073163 Phase 3 Bendamustine;Rituximab
7 Oral Aripiprazole Open-Label Rollover Study Completed NCT01001702 Phase 3 Aripiprazole
8 Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania Unknown status NCT02909712 Phase 2 sulfadoxine-pyrimethamine (SP);dihydroartemisinin-piperaquine (DHA-PQP)
9 4 Week Switch Study in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease Completed NCT01587924 Phase 2 GSK1278863;rhEPO
10 An Investigation Of The Interaction Of GSK961081 With Inhaled Beta-Agonist And Anti-Muscarinic Drugs. Completed NCT00674817 Phase 2 400 microgrammes GSK961081;1200 microgrammes GSK961081
11 The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) at Doses up to 80 Micrograms/Hour (mcg/hr) and Naltrexone on Electrocardiogram (ECG) Intervals in Healthy Volunteers Completed NCT01999114 Phase 1 Buprenorphine transdermal patch;Naltrexone tablet;Placebos (for TDS and for naltrexone and for moxifloxacin);Moxifloxacin tablet
12 Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder Completed NCT01423916 Phase 1 OPC-34712 (4mg);Moxifloxacin;OPC-34712 (12mg);Placebo
13 Study to Assess the Effect of Macitentan on the Electrocardiogram (ECG) in Healthy Male and Female Subjects Completed NCT02050802 Phase 1 Moxifloxacin 400 mg;Macitentan 10 mg;Macitentan 30 mg
14 Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization Unknown status NCT00173342
15 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Unknown status NCT00453700 Not Applicable
16 Right Bundle Branch Block After Surgical Closure of Ventricular Septal Defect Completed NCT01480908 Not Applicable
17 Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease Completed NCT02315300 Not Applicable
18 Hybrid Closure of Congenital Heart Disease Completed NCT02794584 Not Applicable sufentanil anesthesia
19 Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure (The SPARK Trial) Recruiting NCT02441101 Not Applicable
20 Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction. The Study Tests the Superiority of Right Ventricular Bifocal Stimulation Over VVI Implantable Defibrillator in Right Bundle Branch Block and Heart Failure. Recruiting NCT03524001 Not Applicable
21 His Bundle Pacing in Bradycardia and Heart Failure Recruiting NCT03008291
22 Edwards SAPIEN 3 PPI Registry Recruiting NCT03497611
23 Prospective European Multicenter Study on Aortic Valve Replacement: (E-AVR Registry) Recruiting NCT03143361
24 STIMTAVI : Evolution of Atrioventricular Conduction Disorders After TAVI Active, not recruiting NCT03338582
25 Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial) Terminated NCT01169493 Not Applicable

Search NIH Clinical Center for Right Bundle Branch Block

Genetic Tests for Right Bundle Branch Block

Genetic tests related to Right Bundle Branch Block:

# Genetic test Affiliating Genes
1 Right Bundle Branch Block 29

Anatomical Context for Right Bundle Branch Block

MalaCards organs/tissues related to Right Bundle Branch Block:

41
Heart, Kidney, Testes, Lung, Brain, Spinal Cord, Atrioventricular Node

Publications for Right Bundle Branch Block

Articles related to Right Bundle Branch Block:

(show top 50) (show all 704)
# Title Authors Year
1
Heart rate variability is impaired in adults after closure of ventricular septal defect in childhood: A novel finding associated with right bundle branch block. ( 30454724 )
2019
2
Acute biventricular hemodynamic effects of cardiac resynchronization therapy in right bundle branch block. ( 29800750 )
2018
3
A wide complex tachycardia with atypical right bundle branch block QRS morphology: What is the mechanism? ( 29727501 )
2018
4
Clinical characteristics and value in early reperfusion therapy for new onset right bundle branch block in patients with acute myocardial infarction. ( 29467855 )
2018
5
An interesting case of narrow QRS tachycardia with incomplete right bundle branch block morphology: What is the mechanism? ( 29683541 )
2018
6
Prognostic value of new-onset right bundle-branch block in acute myocardial infarction patients: a systematic review and meta-analysis. ( 29576967 )
2018
7
Persistent ventricular preexcitation despite right bundle branch block. ( 29407483 )
2018
8
Utility of incomplete right bundle branch block as an isolated ECG finding in children undergoing initial cardiac evaluation. ( 29431296 )
2018
9
An interesting case of wide QRS tachycardia with right bundle branch block morphology: What is the mechanism? ( 29781518 )
2018
10
Right bundle branch block and conduction disturbances in Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy. ( 29804172 )
2018
11
Prognostic impact of right bundle branch block in hospitalized patients with idiopathic dilated cardiomyopathy: a single-center cohort study. ( 30318986 )
2018
12
Right bundle branch block in patients with suspected myocardial infarction. ( 30362813 )
2018
13
Wide QRS tachycardia with right bundle branch block QRS morphology that is almost identical to that during sinus rhythm: What is the mechanism? ( 29676823 )
2018
14
Right bundle branch block and cardiovascular morbidity and mortality in healthy patients. ( 30139583 )
2018
15
Electrical and mechanical dyssynchrony in patients with right bundle branch block. ( 30143955 )
2018
16
Electrical and mechanical dyssynchrony in patients with right bundle branch block. ( 30298370 )
2018
17
Permanent His Bundle Pacing for Cardiac Resynchronization Therapy in Patients With Heart Failure and Right Bundle Branch Block. ( 30354292 )
2018
18
Recruitment of Complete Right Bundle Branch Block by Permanent Para-Hisian Pacing. ( 30464132 )
2018
19
Alternating Wenckebach cycles with right bundle branch block. ( 30497760 )
2018
20
Atypical ischemic repolarization in right bundle branch block. ( 30553984 )
2018
21
Annals Consult Guys - New Right Bundle Branch Block and Newly Diagnosed Alzheimer's: What to Do? ( 30557441 )
2018
22
The relevance of looking for right bundle branch block in catheter ablation of Ebstein's anomaly. ( 28666538 )
2017
23
Association between right ventricular systolic function and electromechanical delay in patients with right bundle branch block. ( 28238566 )
2017
24
Right bundle branch block and anterior wall ST elevation myocardial infarction. ( 28840315 )
2017
25
Wenckebach pattern in right bundle branch block - benign or not? ( 28340894 )
2017
26
Differentiating the QRS Morphology of Posterior Fascicular Ventricular Tachycardia From Right Bundle Branch Block and Left Anterior Hemiblock Aberrancy. ( 28899954 )
2017
27
Resolution of the functional retrograde right bundle branch block during antidromic atrioventricular reciprocating tachycardia. ( 29387543 )
2017
28
Recurrent extensive anterior myocardial infarction with left and right bundle branch block. ( 29034539 )
2017
29
Successful catheter ablation of focal ventricular tachycardia originating from right bundle branch without making right bundle branch block, using pharmacologic induction by landiolol. ( 29296582 )
2017
30
Right bundle branch block pattern after uncomplicated right ventricular outflow tract pacing in a patient with a left sided superior vena cava and corrected tetralogy of Fallot. ( 29183713 )
2017
31
AV nodal reentrant tachycardia with a 2:1 right bundle branch block missed as bidirectional ventricular tachycardia in the first superficial evaluation. ( 28125405 )
2017
32
Patients with right bundle branch block and concomitant delayed left ventricular activation respond to cardiac resynchronization therapy. ( 29294014 )
2017
33
Think beyond right bundle branch block in atrial septal defect. ( 28994692 )
2017
34
Clinical Impact of Baseline Right Bundle Branch Block in Patients Undergoing Transcatheter Aortic Valve Replacement. ( 28734885 )
2017
35
Pre-Transcatheter Aortic Valve Replacement Right Bundle Branch Block: A Bundle of Trouble. ( 28734886 )
2017
36
Transcatheter Heart Valve Selection and Permanent Pacemaker Implantation in Patients With Pre-Existent Right Bundle Branch Block. ( 28258051 )
2017
37
The electromechanical substrate for response to cardiac resynchronization therapy in patients with right bundle branch block. ( 29086988 )
2017
38
Complete right bundle branch block and QRS-T discordance can be the initial clue to detect S-ICD ineligibility. ( 28034575 )
2016
39
Right ventricular failure predicted from right bundle branch block: cardiac magnetic resonance imaging validation. ( 27747166 )
2016
40
Rare Manifestation of Digoxin Toxicity: Right Bundle Branch Block. ( 28104974 )
2016
41
Sodium channel blockade unmasked Brugada electrocardiographic pattern in a patient with complete right bundle branch block and early repolarization in the lateral leads. ( 27830074 )
2016
42
An interventricular and right intraventricular dyssynchrony related to right bundle branch block appearance as cause of RVOT gradient decrease in a HCM patient. ( 26802821 )
2016
43
Transient complete right bundle branch block following right heart catheterization in children - a report of two cases. ( 27980554 )
2016
44
ECG Case of the Month: IRREGULARLY IRREGULAR CARDIAC RHYTHM IN AN 87-YEAR-OLD WOMAN. MULTIFOCAL ATRIAL TACHYCARDIA; RIGHT BUNDLE BRANCH BLOCK. ( 26986865 )
2016
45
Prognostic Significance of Right Bundle Branch Block for Patients with Acute Myocardial Infarction: A Systematic Review and Meta-Analysis. ( 27017617 )
2016
46
Exercise left ventricular ejection fraction predicts events in right bundle branch block. ( 26634337 )
2016
47
Right bundle branch block and SIQIII-type patterns for risk stratification in acute pulmonary embolism. ( 27083328 )
2016
48
Comorbidities of Chronic Complete Right Bundle Branch Block and Correlations With Coronary Angiographic Findings. ( 26802764 )
2016
49
Postoperative right bundle branch block after closure of ventricular septal defect predicts lower peak heart rate in adulthood. ( 26655532 )
2016
50
Transient right bundle branch block in a patient with acute pulmonary embolism. ( 27817836 )
2016

Variations for Right Bundle Branch Block

ClinVar genetic disease variations for Right Bundle Branch Block:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BMPR2 NM_001204.6(BMPR2): c.2948G> A (p.Arg983Gln) single nucleotide variant Likely benign rs148099152 GRCh38 Chromosome 2, 202559777: 202559777
2 BMPR2 NM_001204.6(BMPR2): c.2948G> A (p.Arg983Gln) single nucleotide variant Likely benign rs148099152 GRCh37 Chromosome 2, 203424500: 203424500

Expression for Right Bundle Branch Block

Search GEO for disease gene expression data for Right Bundle Branch Block.

Pathways for Right Bundle Branch Block

Pathways related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 CACNA1C CACNB2 SCN1B SCN2B SCN3B SCN5A
2
Show member pathways
13.15 CACNA1C CACNB2 SCN1B SCN2B SCN3B SCN5A
3
Show member pathways
12.71 CACNA1C CACNB2 SCN1B SCN2B SCN3B SCN5A
4
Show member pathways
12.48 CACNA1C CACNB2 SCN1B SCN5A TRPM4
5
Show member pathways
12.43 CACNA1C CACNB2 KCND3 SCN1B SCN2B SCN3B
6
Show member pathways
12.32 SCN1B SCN2B SCN3B SCN5A
7
Show member pathways
12.18 BMPR2 CACNA1C CACNB2
8 12.04 CACNA1C CACNB2 KCND3
9 11.88 GPD1L SCN3B SCN5A
10
Show member pathways
11.72 SCN1B SCN2B SCN3B SCN5A
11
Show member pathways
11.31 CACNA1C CACNB2 SCN1B SCN2B SCN3B SCN5A
12 11.23 CACNA1C CACNB2
13 11.09 CACNA1C CACNB2
14 11.03 SCN1B SCN2B SCN3B SCN5A
15 10.97 CACNA1C CACNB2 HCN4 KCND3 SCN1B SCN2B

GO Terms for Right Bundle Branch Block

Cellular components related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.85 BMPR2 CACNA1C CACNB2 GPD1L HCN4 KCND3
2 Z disc GO:0030018 9.61 CACNA1C SCN3B SCN5A
3 intercalated disc GO:0014704 9.51 SCN1B SCN5A
4 T-tubule GO:0030315 9.49 SCN1B SCN5A
5 voltage-gated calcium channel complex GO:0005891 9.48 CACNA1C CACNB2
6 L-type voltage-gated calcium channel complex GO:1990454 9.4 CACNA1C CACNB2
7 sodium channel complex GO:0034706 9.37 SCN1B TRPM4
8 spanning component of plasma membrane GO:0044214 9.32 BMPR2 TRPM4
9 sarcolemma GO:0042383 9.26 CACNA1C CACNB2 KCND3 SCN5A
10 voltage-gated sodium channel complex GO:0001518 8.92 SCN1B SCN2B SCN3B SCN5A
11 integral component of membrane GO:0016021 10.11 BMPR2 CACNA1C HCN4 KCND3 SCN1B SCN2B
12 membrane GO:0016020 10 BMPR2 CACNA1C CACNB2 GPD1L HCN4 KCND3

Biological processes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.97 CACNA1C CACNB2 HCN4 KCND3 SCN1B SCN2B
2 sodium ion transport GO:0006814 9.93 HCN4 SCN1B SCN2B SCN3B SCN5A
3 sodium ion transmembrane transport GO:0035725 9.88 HCN4 SCN1B SCN2B SCN3B SCN5A
4 cardiac muscle contraction GO:0060048 9.86 SCN1B SCN2B SCN3B SCN5A
5 ion transmembrane transport GO:0034220 9.84 CACNA1C SCN5A TRPM4
6 chemical synaptic transmission GO:0007268 9.84 CACNB2 SCN1B SCN2B
7 calcium ion transport GO:0006816 9.82 CACNA1C CACNB2 TRPM4
8 calcium ion transmembrane transport GO:0070588 9.81 CACNA1C CACNB2 TRPM4
9 regulation of sodium ion transmembrane transporter activity GO:2000649 9.8 GPD1L SCN1B SCN2B SCN3B
10 regulation of heart rate GO:0002027 9.77 GPD1L HCN4 SCN5A
11 membrane depolarization GO:0051899 9.76 SCN1B SCN3B SCN5A
12 positive regulation of sodium ion transport GO:0010765 9.76 GPD1L SCN1B SCN3B SCN5A
13 regulation of ion transmembrane transport GO:0034765 9.76 CACNA1C CACNB2 HCN4 KCND3 SCN1B SCN2B
14 ventricular cardiac muscle cell action potential GO:0086005 9.75 GPD1L SCN3B SCN5A
15 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.74 GPD1L SCN3B SCN5A
16 cardiac conduction GO:0061337 9.73 CACNA1C SCN1B SCN3B TRPM4
17 SA node cell action potential GO:0086015 9.72 HCN4 SCN3B SCN5A
18 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.71 SCN1B SCN2B SCN3B SCN5A
19 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.7 CACNA1C CACNB2 SCN5A
20 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.69 SCN1B SCN5A TRPM4
21 membrane depolarization during AV node cell action potential GO:0086045 9.67 CACNA1C CACNB2 SCN5A TRPM4
22 calcium ion import GO:0070509 9.66 CACNA1C CACNB2
23 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 SCN1B SCN5A
24 positive regulation of heart rate GO:0010460 9.65 SCN3B TRPM4
25 cardiac muscle cell action potential involved in contraction GO:0086002 9.65 CACNA1C SCN1B SCN2B SCN3B SCN5A
26 membrane depolarization during action potential GO:0086010 9.64 SCN3B SCN5A
27 sodium ion import across plasma membrane GO:0098719 9.63 HCN4 TRPM4
28 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.63 CACNA1C TRPM4
29 atrial cardiac muscle cell action potential GO:0086014 9.62 SCN3B SCN5A
30 membrane depolarization during SA node cell action potential GO:0086046 9.61 HCN4 SCN5A
31 response to pyrethroid GO:0046684 9.61 SCN1B SCN2B
32 regulation of heart rate by cardiac conduction GO:0086091 9.61 CACNA1C CACNB2 HCN4 KCND3 SCN1B SCN2B
33 membrane depolarization during bundle of His cell action potential GO:0086048 9.6 SCN5A TRPM4
34 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.1 CACNA1C HCN4 SCN1B SCN2B SCN3B SCN5A
35 transmembrane transport GO:0055085 10.02 CACNA1C HCN4 KCND3 SCN5A TRPM4

Molecular functions related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 9.77 GPD1L KCND3 SCN1B SCN3B SCN5A
2 ion channel activity GO:0005216 9.73 CACNA1C HCN4 SCN5A TRPM4
3 calmodulin binding GO:0005516 9.71 CACNA1C SCN5A TRPM4
4 calcium channel activity GO:0005262 9.7 CACNA1C CACNB2 TRPM4
5 sodium channel regulator activity GO:0017080 9.62 GPD1L SCN1B SCN2B SCN3B
6 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.56 SCN1B SCN2B SCN3B SCN5A
7 voltage-gated calcium channel activity GO:0005245 9.55 CACNA1C CACNB2
8 voltage-gated sodium channel activity GO:0005248 9.55 HCN4 SCN1B SCN2B SCN3B SCN5A
9 high voltage-gated calcium channel activity GO:0008331 9.51 CACNA1C CACNB2
10 voltage-gated ion channel activity GO:0005244 9.5 CACNA1C HCN4 KCND3 SCN1B SCN2B SCN3B
11 sodium channel inhibitor activity GO:0019871 9.49 SCN1B SCN3B
12 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.48 CACNA1C CACNB2
13 voltage-gated calcium channel activity involved in AV node cell action potential GO:0086056 9.46 CACNA1C CACNB2
14 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.4 SCN1B SCN5A
15 sodium channel activity GO:0005272 9.1 HCN4 SCN1B SCN2B SCN3B SCN5A TRPM4

Sources for Right Bundle Branch Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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