MCID: RGH001
MIFTS: 47

Right Bundle Branch Block

Categories: Cardiovascular diseases

Aliases & Classifications for Right Bundle Branch Block

MalaCards integrated aliases for Right Bundle Branch Block:

Name: Right Bundle Branch Block 12 29 54 6 15 70
Right Bundle Branch Block with Left Posterior Fascicular Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13209
ICD9CM 34 426.51
SNOMED-CT 67 46319007
UMLS 70 C0085615 C0155704

Summaries for Right Bundle Branch Block

MalaCards based summary : Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome 1 and brugada syndrome 2. An important gene associated with Right Bundle Branch Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Developmental Biology and G-Beta Gamma Signaling. Affiliated tissues include heart, atrioventricular node and brain, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 A right bundle branch block (RBBB) is a heart block in the right bundle branch of the electrical... more...

Related Diseases for Right Bundle Branch Block

Diseases related to Right Bundle Branch Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
# Related Disease Score Top Affiliating Genes
1 brugada syndrome 1 32.5 SCN5A KCNH2 KCND3
2 brugada syndrome 2 32.5 SCN5A GPD1L
3 brugada syndrome 5 32.4 SCN5A SCN1B KCND3
4 brugada syndrome 6 32.4 SCN5A KCNE3
5 ventricular fibrillation, paroxysmal familial, 1 32.1 SCN5A KCNH2 CACNA1C
6 brugada syndrome 4 31.7 SCN5A KCNH2 CACNB2 CACNA1C
7 cardiac conduction defect 31.0 TRPM4 SCN5A SCN1B DSG2 CACNA1C
8 wolff-parkinson-white syndrome 30.9 TNNI3 SCN5A NPPB
9 anterolateral myocardial infarction 30.8 NPPB ACE
10 second-degree atrioventricular block 30.6 TNNI3 SCN5A SCN3B HCN4
11 left bundle branch hemiblock 30.6 TNNI3 SCN5A PKP2 NPPB DSG2 ACE
12 congestive heart failure 30.6 TNNI3 SCN5A NPPB CACNA1C ACE
13 inferior myocardial infarction 30.6 TNNI3 NPPB ACE
14 pulmonary embolism 30.5 TNNI3 NPPB ACE
15 myocarditis 30.4 TNNI3 NPPB ACE
16 angina pectoris 30.4 TNNI3 NPPB ACE
17 pulmonary valve insufficiency 30.3 NPPB BMPR2 ACE
18 heart valve disease 30.3 TNNI3 NPPB ACE
19 mitral valve insufficiency 30.2 TNNI3 NPPB ACE
20 patent foramen ovale 30.1 TRPM4 TNNI3 NPPB ACE
21 sick sinus syndrome 30.0 SCN5A SCN3B SCN1B RANGRF HCN4 CACNA1C
22 pericarditis 30.0 TNNI3 NPPB ACE
23 pericardial effusion 30.0 TNNI3 NPPB ACE
24 first-degree atrioventricular block 30.0 SCN5A NPPB KCNH2 ACE
25 pulmonary edema 30.0 TNNI3 NPPB ACE
26 atrial standstill 1 29.9 TNNI3 SCN5A SCN1B PKP2 NPPB DSG2
27 tetralogy of fallot 29.9 TNNI3 SCN5A PRODH NPPB KCNH2 ACE
28 atrioventricular block 29.9 TRPM4 TNNI3 SCN5A NPPB KCNH2 HCN4
29 atrial heart septal defect 29.9 TNNI3 SCN5A PRODH NPPB HCN4 BMPR2
30 tricuspid valve insufficiency 29.8 TNNI3 NPPB BMPR2 ACE
31 atrial fibrillation 29.5 SCN5A SCN3B SCN2B SCN1B NPPB KCNH2
32 third-degree atrioventricular block 29.4 SCN5A SCN1B NPPB KCNH2 HCN4 ACE
33 arrhythmogenic right ventricular cardiomyopathy 29.3 TRPM4 SCN5A PKP2 NPPB KCNH2 HCN4
34 cardiac arrhythmia 29.1 SCN5A SCN3B SCN1B RANGRF PKP2 KCNH2
35 lipoprotein quantitative trait locus 29.1 TNNI3 SCN5A PKP2 NPPB KCNH2 HCN4
36 cardiac arrest 28.8 TNNI3 SCN5A NPPB KCNH2 HCN4 DSG2
37 sinoatrial node disease 28.8 SCN5A SCN3B SCN1B RANGRF KCNH2 KCND3
38 brugada syndrome 28.8 TRPM4 TNNI3 SCN5A SCN3B SCN2B SCN1B
39 hypertrophic cardiomyopathy 28.1 TRPM4 TNNI3 SCN5A PKP2 NPPB KCNH2
40 heart disease 28.0 TNNI3 SCN5A PRODH PKP2 NPPB KCNH2
41 dilated cardiomyopathy 27.8 TNNI3 SCN5A SCN2B PKP2 NPPB KCNH2
42 long qt syndrome 27.6 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2
43 left ventricular noncompaction 27.1 TNNI3 SCN5A SCN3B SCN2B SCN1B RANGRF
44 progressive familial heart block, type ib 12.0
45 progressive familial heart block, type ia 11.9
46 brugada syndrome 3 11.4
47 brugada syndrome 7 11.4
48 brugada syndrome 8 11.4
49 brugada syndrome 9 11.4
50 acute myocardial infarction 10.9

Comorbidity relations with Right Bundle Branch Block via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Aortic Valve Disease 1
Atrioventricular Block Benign Essential Hypertension
Bronchitis Chronic Pulmonary Heart Disease
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Left Bundle Branch Hemiblock Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Prostatic Hypertrophy Pulmonary Hypertension, Primary, 1
Respiratory Failure Sinoatrial Node Disease
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to Right Bundle Branch Block

Symptoms & Phenotypes for Right Bundle Branch Block

GenomeRNAi Phenotypes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.53 BMPR2
2 Decreased viability GR00221-A-1 9.53 BMPR2
3 Decreased viability GR00221-A-3 9.53 BMPR2
4 Decreased viability GR00221-A-4 9.53 BMPR2
5 Decreased viability GR00249-S 9.53 BMPR2 CACNA1C KCNE3 PRODH SCN1B SCN2B
6 Decreased viability GR00301-A 9.53 BMPR2
7 Decreased viability GR00381-A-1 9.53 PRODH
8 Decreased viability GR00402-S-2 9.53 SCN1B SCN5A

MGI Mouse Phenotypes related to Right Bundle Branch Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.83 ACE BMPR2 CACNA1C CACNB2 DSG2 HCN4
2 muscle MP:0005369 9.28 BMPR2 CACNA1C DSG2 HCN4 KCNH2 PKP2

Drugs & Therapeutics for Right Bundle Branch Block

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization Unknown status NCT00173342
2 Postoperative Right Bundle Branch Block - Long-term Effect on the Right Ventricle in Children Operated for Ventricular Septal Defect Completed NCT01480908
3 Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction Recruiting NCT03524001
4 Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure, a Pilot Clinical Trial (The SPARK Trial) Recruiting NCT02441101
5 Permanent Left Bundle Branch Area Pacing for Atrioventricular Block Recruiting NCT03851315
6 Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial) Terminated NCT01169493

Search NIH Clinical Center for Right Bundle Branch Block

Genetic Tests for Right Bundle Branch Block

Genetic tests related to Right Bundle Branch Block:

# Genetic test Affiliating Genes
1 Right Bundle Branch Block 29

Anatomical Context for Right Bundle Branch Block

MalaCards organs/tissues related to Right Bundle Branch Block:

40
Heart, Atrioventricular Node, Brain, Spinal Cord, Kidney, Myeloid, Endothelial

Publications for Right Bundle Branch Block

Articles related to Right Bundle Branch Block:

(show top 50) (show all 3509)
# Title Authors PMID Year
1
Brugada disease: chronology of discovery and paternity. Preliminary observations and historical aspects. 54 61
16943925 2003
2
A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. 61 54
10940383 2000
3
Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. 54 61
10662748 2000
4
Cardiac conduction abnormalities in patients with degenerated bioprostheses undergoing transcatheter aortic valve-in-valve implantations and their impact on long-term outcomes. 61
33592238 2021
5
Transcatheter aortic valve replacement performed with selective telemetry monitoring: A prospective study. 61
33621627 2021
6
Evaluation of the incidence, timing, and potential recovery rates of complete atrioventricular block after transcatheter aortic valve implantation: a Japanese multicenter registry study. 61
32418052 2021
7
Early and late post-operative arrhythmias after surgical myectomy: 45 years of follow-up. 61
33271205 2021
8
Case 288: Uhl Anomaly. 61
33750225 2021
9
Impact of Baseline Right Bundle Branch Block on Outcomes After Pulmonary Vein Isolation in Patients With Atrial Fibrillation. 61
33385350 2021
10
Epicardial adipose tissue predicted prolonged QTc interval in patients with arterial hypertension. 61
33183070 2021
11
Physiology-based electrocardiographic criteria for left bundle branch capture. 61
33677102 2021
12
[Long-term outcome of 48 unoperated adult patients with Ebstein's anomaly]. 61
33706460 2021
13
Predicting need for pacemaker implantation early and late after transcatheter aortic valve implantation. 61
32857905 2021
14
Role of Provocable Brugada ECG Pattern in The Correct Risk Stratification for Major Arrhythmic Events. 61
33801474 2021
15
A 32-Year-Old Man Diagnosed with Type II Brugada Syndrome on Preoperative Electrocardiogram 1 Week Before Elective Tympanoplasty. 61
33737506 2021
16
Pathological findings of myocardium in a patient with cardiac conduction defect associated with an SCN5A mutation. 61
33651170 2021
17
Association between electrocardiographic features and mortality in COVID-19 patients. 61
33742501 2021
18
Predictors of permanent pacemaker insertion after TAVR: A systematic review and updated meta-analysis. 61
33682218 2021
19
Is the left bundle branch pacing a choice to conquer the right bundle branch block?-A case report. 61
32896950 2021
20
Remote magnetic-guided ablation for three origins of idiopathic ventricular arrhythmias with right bundle branch block and superior axis. 61
33471947 2021
21
Alcohol-induced right bundle branch block is associated with a benign outcome in HOCM after alcohol septum ablation (ASA). 61
33772362 2021
22
Exploring the cause of conduction delays in patients with repaired Tetralogy of Fallot. 61
33751080 2021
23
The Footprints of Pacing Lead Position Using the 12-Lead Electrocardiograph. 61
33162365 2021
24
Automated detection of arrhythmia from electrocardiogram signal based on new convolutional encoded features with bidirectional long short-term memory network classifier. 61
33405209 2021
25
Predictors of pacemaker implantation after transcatheter aortic valve implantation according to kind of prosthesis and risk profile: a systematic review and contemporary meta-analysis. 61
33289527 2021
26
Clinical factors associated with the intraventricular conduction disturbances in Swiss middle-aged adults: The CoLaus|PsyCoLaus study. 61
33309760 2021
27
[Localization of ventricular premature contractions by 12-lead ECG]. 61
33533995 2021
28
Hybrid Transthoracic Periventricular Device Closure of Ventricular Septal Defects: Single- Center Experience. 61
33118345 2021
29
Belhassen Ventricular Tachycardia in a Child. 61
33654570 2021
30
A regularly irregular tachycardia with variable QRS morphologies - What is the mechanism? 61
33621799 2021
31
On the nonpathological nature of ST-segment elevation in lateral leads in patients with CRBBB. 61
33565606 2021
32
Alternating wide complex tachycardia after surgical aortic valve replacement. 61
33556500 2021
33
Correlation of cardiac function and cerebral perfusion in a murine model of subarachnoid hemorrhage. 61
33558609 2021
34
Predictors of permanent pacemaker implantation after ACURATE neo transcatheter heart valve implantation. 61
33373045 2021
35
Catheter ablation of an antidromic atrioventricular reentrant tachycardia using a slow, decrementally conducting accessory pathway in the great cardiac vein. 61
33001504 2021
36
Three-Dimensional Printing, Virtual Reality and Mixed Reality for Pulmonary Atresia: Early Surgical Outcomes Evaluation. 61
32863113 2021
37
Late-onset Hereditary ATTR Amyloidosis with a Novel p.P63S (P43S) Transthyretin Variant. 61
32999234 2021
38
Acute myocardial infarction with right bundle branch block at presentation: Prevalence and mortality. 61
33770645 2021
39
Right bundle branch block-type wide QRS complex tachycardia with a reversed R/S complex in lead V6: Development and validation of electrocardiographic differentiation criteria. 61
32927100 2021
40
In Hospital Outcomes of Patients With Right Bundle Branch Block and Anterior Wall ST-Segment Elevation Myocardial Infarction (From a Nationwide Study Using the National Inpatient Sample). 61
33147431 2021
41
ECG Changes in a Case of Posterior Myocardial Infarction in the Presence of Right Bundle Branch Block. 61
33728214 2021
42
A dual nodal response to the parahisian pacing and induction of the retrograde right bundle branch block maneuvers. 61
33664918 2021
43
How to Estimate QT Interval in Patients With Left or Right Bundle Branch Block: A Systematic Review. 61
33657070 2021
44
Periaortic Ventricular Tachycardias in Nonischemic Cardiomyopathy: Substrate and Electrocardiographic Correlations. 61
33417473 2021
45
Right bundle branch block ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathy more commonly originates from the right ventricle: Criteria for identifying chamber of origin. 61
32889109 2021
46
Standard ECG for differential diagnosis between Anderson-Fabry disease and hypertrophic cardiomyopathy. 61
33563631 2021
47
Electrocardiographic Strain Pattern Is a Major Determinant of Rehospitalization for Heart Failure After Transcatheter Aortic Valve Replacement. 61
33459031 2021
48
Evolution of high-grade atrioventricular conduction disorders after transcatheter aortic valve implantation in patients who underwent implantation of a pacemaker with specific mode-that minimizes ventricular pacing-activated. 61
33625762 2021
49
[Peri-ictal electrocardiographic alterations in paediatric epilepsy patients. A prospective study]. 61
33570157 2021
50
Brugada syndrome: Eligibility for subcutaneous implantable cardioverter-defibrillator after exercise stress test. 61
33436324 2021

Variations for Right Bundle Branch Block

ClinVar genetic disease variations for Right Bundle Branch Block:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 BMPR2 NM_001204.7(BMPR2):c.2948G>A (p.Arg983Gln) SNV Uncertain significance 333652 rs148099152 GRCh37: 2:203424500-203424500
GRCh38: 2:202559777-202559777

Expression for Right Bundle Branch Block

Search GEO for disease gene expression data for Right Bundle Branch Block.

Pathways for Right Bundle Branch Block

Pathways related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.31 SCN5A SCN3B SCN2B SCN1B PKP2 DSG2
2
Show member pathways
12.86 SCN5A SCN3B SCN2B SCN1B CACNB2 CACNA1C
3
Show member pathways
12.62 TNNI3 SCN5A SCN3B SCN2B SCN1B RANGRF
4
Show member pathways
12.3 TNNI3 SCN5A SCN1B NPPB CACNB2 CACNA1C
5 12.12 KCNH2 KCNE3 KCND3 CACNB2 CACNA1C
6
Show member pathways
12.05 TNNI3 CACNB2 CACNA1C ACE
7 11.97 SCN5A SCN3B KCNH2 GPD1L
8 11.92 PKP2 DSG2 CACNB2 CACNA1C
9
Show member pathways
11.8 SCN5A SCN3B SCN2B SCN1B
10 11.64 TNNI3 CACNB2 CACNA1C
11
Show member pathways
11.43 SCN5A SCN3B SCN2B SCN1B RANGRF KCNE3
12 11.07 SCN5A SCN3B SCN2B SCN1B KCNH2 KCNE3
13 11.03 SCN5A SCN3B SCN2B SCN1B

GO Terms for Right Bundle Branch Block

Cellular components related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.34 TRPM4 SCN5A SCN3B SCN2B SCN1B RANGRF
2 integral component of membrane GO:0016021 10.17 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2
3 plasma membrane GO:0005886 10.06 TRPM4 SCN5A SCN3B SCN1B RANGRF PKP2
4 voltage-gated potassium channel complex GO:0008076 9.65 KCNH2 KCNE3 KCND3
5 caveola GO:0005901 9.63 SCN5A RANGRF BMPR2
6 sarcolemma GO:0042383 9.56 SCN5A KCND3 CACNB2 CACNA1C
7 T-tubule GO:0030315 9.54 SCN5A SCN1B CACNA1C
8 spanning component of plasma membrane GO:0044214 9.51 TRPM4 BMPR2
9 L-type voltage-gated calcium channel complex GO:1990454 9.49 CACNB2 CACNA1C
10 sodium channel complex GO:0034706 9.4 TRPM4 SCN1B
11 voltage-gated sodium channel complex GO:0001518 9.26 SCN5A SCN3B SCN2B SCN1B
12 intercalated disc GO:0014704 9.02 SCN5A SCN1B RANGRF PKP2 DSG2

Biological processes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.14 TRPM4 SCN5A KCNH2 KCND3 HCN4 CACNA1C
2 ion transport GO:0006811 10.14 TRPM4 SCN5A SCN3B SCN2B SCN1B KCNH2
3 ion transmembrane transport GO:0034220 10.04 TRPM4 SCN5A SCN3B SCN1B KCNH2
4 sodium ion transport GO:0006814 10 SCN5A SCN3B SCN2B SCN1B HCN4
5 sodium ion transmembrane transport GO:0035725 9.98 SCN5A SCN3B SCN2B SCN1B HCN4
6 potassium ion transport GO:0006813 9.95 KCNH2 KCNE3 KCND3 HCN4
7 potassium ion transmembrane transport GO:0071805 9.95 KCNH2 KCNE3 KCND3 HCN4
8 regulation of membrane potential GO:0042391 9.93 TRPM4 RANGRF KCNH2 HCN4
9 cardiac muscle contraction GO:0060048 9.91 TNNI3 SCN5A SCN3B SCN2B SCN1B KCNH2
10 regulation of heart rate GO:0002027 9.88 SCN5A RANGRF HCN4 GPD1L
11 regulation of sodium ion transmembrane transporter activity GO:2000649 9.88 SCN3B SCN2B SCN1B RANGRF GPD1L
12 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.86 SCN5A SCN1B KCNH2 KCNE3
13 positive regulation of sodium ion transport GO:0010765 9.85 SCN5A SCN3B SCN1B PKP2 GPD1L
14 ventricular cardiac muscle cell action potential GO:0086005 9.85 SCN5A SCN3B PKP2 KCNH2 KCNE3 GPD1L
15 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.83 TRPM4 PKP2 DSG2 CACNA1C
16 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.81 SCN5A SCN3B SCN2B SCN1B
17 membrane depolarization GO:0051899 9.8 SCN5A SCN3B SCN1B
18 membrane depolarization during AV node cell action potential GO:0086045 9.8 TRPM4 SCN5A CACNB2 CACNA1C
19 cardiac muscle cell action potential involved in contraction GO:0086002 9.8 SCN5A SCN3B SCN2B SCN1B PKP2 CACNA1C
20 membrane depolarization during action potential GO:0086010 9.79 SCN5A SCN3B KCNH2
21 potassium ion export across plasma membrane GO:0097623 9.79 KCNH2 KCNE3 KCND3
22 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.78 KCNH2 KCNE3 KCND3
23 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.77 SCN5A SCN3B GPD1L
24 cardiac conduction GO:0061337 9.76 TRPM4 SCN5A SCN3B SCN1B KCNH2 KCND3
25 SA node cell action potential GO:0086015 9.74 SCN5A SCN3B HCN4
26 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.73 SCN5A SCN3B SCN2B SCN1B HCN4 CACNA1C
27 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.72 SCN5A CACNB2 CACNA1C
28 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.71 TRPM4 SCN5A SCN1B
29 sodium ion import across plasma membrane GO:0098719 9.7 TRPM4 HCN4
30 positive regulation of protein localization to cell surface GO:2000010 9.7 RANGRF GPD1L
31 heart contraction GO:0060047 9.7 TNNI3 ACE
32 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.7 PKP2 CACNA1C
33 negative regulation of systemic arterial blood pressure GO:0003085 9.69 NPPB BMPR2
34 membrane repolarization GO:0086009 9.69 KCNH2 KCND3
35 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.69 KCNH2 KCND3
36 atrial cardiac muscle cell action potential GO:0086014 9.68 SCN5A SCN3B
37 membrane repolarization during action potential GO:0086011 9.68 KCNH2 KCNE3
38 regulation of sodium ion transmembrane transport GO:1902305 9.68 SCN5A RANGRF
39 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.68 RANGRF HCN4
40 regulation of membrane depolarization GO:0003254 9.67 RANGRF HCN4
41 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.67 PKP2 DSG2
42 desmosome organization GO:0002934 9.67 PKP2 DSG2
43 membrane depolarization during SA node cell action potential GO:0086046 9.66 SCN5A HCN4
44 response to pyrethroid GO:0046684 9.65 SCN2B SCN1B
45 regulation of ion transmembrane transport GO:0034765 9.65 SCN5A SCN3B SCN2B SCN1B KCNH2 KCNE3
46 negative regulation of potassium ion export across plasma membrane GO:1903765 9.64 KCNH2 KCNE3
47 membrane depolarization during bundle of His cell action potential GO:0086048 9.63 TRPM4 SCN5A
48 regulation of heart rate by cardiac conduction GO:0086091 9.44 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2

Molecular functions related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.88 TRPM4 SCN5A KCNH2 KCND3 HCN4 CACNA1C
2 potassium channel activity GO:0005267 9.78 KCNH2 KCNE3 KCND3 HCN4
3 voltage-gated potassium channel activity GO:0005249 9.76 KCNH2 KCNE3 KCND3 HCN4
4 calcium channel activity GO:0005262 9.75 TRPM4 CACNB2 CACNA1C
5 sodium channel activity GO:0005272 9.72 SCN5A SCN3B SCN2B SCN1B HCN4
6 voltage-gated sodium channel activity GO:0005248 9.67 SCN5A SCN2B SCN1B HCN4
7 sodium channel regulator activity GO:0017080 9.63 SCN3B SCN2B SCN1B RANGRF PKP2 GPD1L
8 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.61 KCNH2 KCNE3 KCND3
9 high voltage-gated calcium channel activity GO:0008331 9.57 CACNB2 CACNA1C
10 sodium channel inhibitor activity GO:0019871 9.56 SCN3B SCN1B
11 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.56 SCN5A SCN3B SCN2B SCN1B
12 ion channel binding GO:0044325 9.56 SCN5A SCN3B SCN1B RANGRF PKP2 KCNE3
13 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.55 KCNH2 KCND3
14 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.54 PKP2 DSG2
15 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.52 CACNB2 CACNA1C
16 voltage-gated calcium channel activity involved in AV node cell action potential GO:0086056 9.51 CACNB2 CACNA1C
17 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.49 SCN5A SCN1B
18 voltage-gated ion channel activity GO:0005244 9.32 SCN5A SCN3B SCN2B SCN1B KCNH2 KCNE3

Sources for Right Bundle Branch Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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