MCID: RGH001
MIFTS: 48

Right Bundle Branch Block

Categories: Cardiovascular diseases

Aliases & Classifications for Right Bundle Branch Block

MalaCards integrated aliases for Right Bundle Branch Block:

Name: Right Bundle Branch Block 12 29 54 6 15 71
Right Bundle Branch Block with Left Posterior Fascicular Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13209
ICD9CM 34 426.51
SNOMED-CT 67 46319007
UMLS 71 C0085615 C0155704

Summaries for Right Bundle Branch Block

MalaCards based summary : Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to brugada syndrome 2 and brugada syndrome 5. An important gene associated with Right Bundle Branch Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Developmental Biology and G-Beta Gamma Signaling. The drugs Enalapril and Carvedilol have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 A right bundle branch block (RBBB) is a heart block in the right bundle branch of the electrical... more...

Related Diseases for Right Bundle Branch Block

Diseases related to Right Bundle Branch Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 brugada syndrome 2 32.9 SCN5A GPD1L
2 brugada syndrome 5 32.9 SCN5A SCN1B KCND3
3 brugada syndrome 4 32.8 SCN5A CACNB2 CACNA1C
4 brugada syndrome 6 32.8 SCN5A KCNE3
5 wolff-parkinson-white syndrome 31.1 SCN5A NPPB HCN4
6 brugada syndrome 31.0 TRPM4 SCN5A SCN3B SCN2B SCN1B RANGRF
7 inferior myocardial infarction 30.9 NPPB CA5B
8 congestive heart failure 30.9 SCN5A NPPB CACNA1C ACE
9 second-degree atrioventricular block 30.9 SCN5A SCN3B HCN4 CA5B
10 atrial standstill 1 30.7 SCN5A SCN1B PKP2 NPPB ACE
11 anterolateral myocardial infarction 30.6 NPPB ACE
12 progressive familial heart block 30.6 TRPM4 SCN5A SCN1B
13 atrioventricular block 30.6 TRPM4 SCN5A NPPB HCN4 CACNA1C CA5B
14 left bundle branch hemiblock 30.6 SCN5A PKP2 NPPB NACC2 CA5B ACE
15 tetralogy of fallot 30.6 SCN5A PRODH NPPB CA5B ACE
16 first-degree atrioventricular block 30.2 SCN5A NPPB DSG4 ACE
17 arrhythmogenic right ventricular cardiomyopathy 30.2 TRPM4 SCN5A PKP2 NPPB HCN4 CACNB2
18 cardiac arrest 30.2 TRPM4 SCN5A NPPB HCN4 CACNB2 ACE
19 atrial heart septal defect 30.1 SCN5A PRODH NPPB HCN4 BMPR2 ACE
20 cardiac arrhythmia 30.1 SCN5A RANGRF PKP2 CACNA1C
21 pulmonary valve insufficiency 30.0 NPPB CA5B BMPR2 ACE
22 sinoatrial node disease 30.0 SCN5A SCN3B SCN1B KCND3 HCN4 CACNA1C
23 patent foramen ovale 30.0 TRPM4 NPPB ACE
24 tricuspid valve insufficiency 30.0 NPPB CA5B BMPR2 ACE
25 sick sinus syndrome 30.0 SCN5A SCN3B SCN1B RANGRF HCN4 CACNA1C
26 hypertrophic cardiomyopathy 29.5 TRPM4 SCN5A PKP2 NPPB HCN4 GPD1L
27 atrial fibrillation 29.5 SCN5A SCN3B SCN2B SCN1B NPPB KCND3
28 third-degree atrioventricular block 29.5 SCN5A NPPB HCN4 DSG4 CA5B ACE
29 left ventricular noncompaction 29.4 SCN5A SCN3B SCN2B PKP2 HCN4 GPD1L
30 heart disease 29.2 SCN5A PRODH PKP2 NPPB HCN4 CACNB2
31 dilated cardiomyopathy 29.1 SCN5A SCN2B PKP2 NPPB KCND3 HCN4
32 long qt syndrome 28.9 TRPM4 SCN5A SCN1B PKP2 KCNE3 KCND3
33 progressive familial heart block, type ib 12.6
34 brugada syndrome 1 12.4
35 progressive familial heart block, type ia 12.3
36 ventricular fibrillation, paroxysmal familial, 1 11.9
37 brugada syndrome 3 11.5
38 brugada syndrome 7 11.5
39 brugada syndrome 8 11.5
40 brugada syndrome 9 11.5
41 acute myocardial infarction 10.8
42 heart septal defect 10.8
43 ventricular septal defect 10.7
44 myocardial infarction 10.7
45 syncope 10.7
46 cardiac conduction defect 10.7
47 ischemia 10.5
48 anteroseptal myocardial infarction 10.5
49 pulmonary embolism 10.5
50 cardiogenic shock 10.5

Comorbidity relations with Right Bundle Branch Block via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Aortic Valve Disease 1
Atrioventricular Block Benign Essential Hypertension
Bronchitis Chronic Pulmonary Heart Disease
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Left Bundle Branch Hemiblock Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Prostatic Hypertrophy Pulmonary Hypertension, Primary, 1
Respiratory Failure Sinoatrial Node Disease
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to Right Bundle Branch Block

Symptoms & Phenotypes for Right Bundle Branch Block

GenomeRNAi Phenotypes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.6 BMPR2
2 Decreased viability GR00221-A-1 9.6 BMPR2
3 Decreased viability GR00221-A-3 9.6 BMPR2
4 Decreased viability GR00221-A-4 9.6 BMPR2
5 Decreased viability GR00249-S 9.6 BMPR2 CACNA1C KCNE3 PRODH SCN1B SCN2B
6 Decreased viability GR00301-A 9.6 BMPR2
7 Decreased viability GR00381-A-1 9.6 NACC2 PRODH
8 Decreased viability GR00402-S-2 9.6 DSG4 NACC2 SCN1B SCN5A

MGI Mouse Phenotypes related to Right Bundle Branch Block:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.4 ACE BMPR2 CACNA1C CACNB2 HCN4 KCND3

Drugs & Therapeutics for Right Bundle Branch Block

Drugs for Right Bundle Branch Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
2
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
3
Enalaprilat Approved Phase 4 76420-72-9 6917719
4 Adrenergic alpha-Antagonists Phase 4
5 Adrenergic beta-Antagonists Phase 4
6 Antihypertensive Agents Phase 4
7 Natriuretic Peptide, Brain Phase 4
8 Adrenergic Agents Phase 4
9 Adrenergic Antagonists Phase 4
10 Antioxidants Phase 4
11 Hormones Phase 4
12 Vasodilator Agents Phase 4
13 Neurotransmitter Agents Phase 4
14 Adrenergic alpha-1 Receptor Antagonists Phase 4
15 Protective Agents Phase 4
16 Calcium, Dietary Phase 4
17 calcium channel blockers Phase 4
18
Calcium Nutraceutical Phase 4 7440-70-2 271
19 Bronchodilator Agents

Interventional clinical trials:

(show all 26)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Carvedilol After Renin-angiotensin System Inhibition in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
2 Prevention of Early Readmission in Elderly Congestive Heart Failure Patients Completed NCT00000475 Phase 2
3 Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization Unknown status NCT00173342
4 Clinical Profile of Patients With Pulmonary Hypertension Due to Lung Diseases ( Single Center Experience) Unknown status NCT02774928
5 Postoperative Right Bundle Branch Block - Long-term Effect on the Right Ventricle in Children Operated for Ventricular Septal Defect Completed NCT01480908
6 Genetic Architecture of Heart Disease in Rural Brazil Completed NCT00023556
7 Imaging of Ventricular Reversed Remodeling After Double Lung Transplantation in Patients With Pulmonary Arterial Hypertension Completed NCT02391441
8 Ventricular Electrical Synchronization by Stimulating Left and Right Bundle Branches Area in Pacing-indicated Patients Completed NCT04023890
9 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Completed NCT00453700
10 SL-AF Trial - (Six Lead Identification of Atrial Fibrillation [AF]) Completed NCT02401451
11 Risk of Cardiovascular Disease in Soccer Referees: a Cross Sectional Study Completed NCT03171285
12 Novel Methods for Arrhythmia Detection: Chest Strap ECG and Wrist Band Photoplethysmography Compared to Holter-device for Atrial Fibrillation Detection Completed NCT03721601
13 Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease Completed NCT02315300
14 Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease - Validation Study Completed NCT02778269
15 Biventricular Pacing in Children After Surgery for Congenital Heart Disease Completed NCT02806245
16 Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure, a Pilot Clinical Trial (The SPARK Trial) Recruiting NCT02441101
17 Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following Transcatheter Aortic Valve Replacement. The PROMOTE Study Recruiting NCT04139616
18 Permanent Left Bundle Branch Area Pacing for Atrioventricular Block Recruiting NCT03851315
19 Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction Recruiting NCT03524001
20 Right Ventricular Pacing to Treat Right Ventricular Failure: A Single Arm Hemodynamic Study Recruiting NCT04194632
21 Chest Strap and PPG-device Compared to Holter-device for Atrial Fibrillation Detection: 24 Hour Study Recruiting NCT03507335
22 1- Year Follow-up After TAVR Performed Without Systematic Intensive Care Unit Admission Recruiting NCT04335149
23 Comparison of Cardiac Function Between Left Bundle Branch Pacing and Right Ventricular Outflow Tract Septal Pacing in Pacemaker-dependent Patients Recruiting NCT04386473
24 Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block: an Observational and Prospective Study. Not yet recruiting NCT04328649
25 Accuracy of Cardiac Arrhythmias and Conduction Disorders Diagnosis Using Smartwatch (Apple Watch®) in Comparison to Conventional Electrocardiogram in Patients With Cardiovascular Disease Not yet recruiting NCT04437914
26 Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial) Terminated NCT01169493

Search NIH Clinical Center for Right Bundle Branch Block

Genetic Tests for Right Bundle Branch Block

Genetic tests related to Right Bundle Branch Block:

# Genetic test Affiliating Genes
1 Right Bundle Branch Block 29

Anatomical Context for Right Bundle Branch Block

MalaCards organs/tissues related to Right Bundle Branch Block:

40
Heart, Testes, Kidney, Lung, Brain, Atrioventricular Node, Spinal Cord

Publications for Right Bundle Branch Block

Articles related to Right Bundle Branch Block:

(show top 50) (show all 3355)
# Title Authors PMID Year
1
Brugada disease: chronology of discovery and paternity. Preliminary observations and historical aspects. 54 61
16943925 2003
2
A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. 61 54
10940383 2000
3
Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. 61 54
10662748 2000
4
Noncompaction cardiomyopathy and multiple coronary-cameral fistulae in an octogenarian. 61
32547659 2020
5
Electrocardiographic features of right bundle branch block in Netherland dwarf rabbits. 61
32323327 2020
6
Pacemaker and conduction disturbances in patients with atrial septal defect. 61
32498739 2020
7
Left bundle branch pacing improved heart function in a 10-year-old child after a 3-month follow-up. 61
32529257 2020
8
Autopsy evaluation of the implantation site of a his bundle pacing lead demonstrating selective capture. 61
32548908 2020
9
The impact of an ultra-trail on the dynamic of cardiac, inflammatory, renal and oxidative stress biological markers correlated with electrocardiogram and echocardiogram. 61
32539581 2020
10
Audit of a cardiac screening policy for elite Australian cricketers. 61
31956043 2020
11
Aortic Valve Calcification as a Predictor of Post-Transcatheter Aortic Valve Replacement Pacemaker Dependence. 61
32494325 2020
12
Clinical correlates and outcome of the patterns of premature ventricular beats in Olympic athletes: a long-term follow-up study. 61
32484042 2020
13
Cardiac rhythm abnormalities - An underestimated cardiovascular risk in adult patients with Mucopolysaccharidoses. 61
32241717 2020
14
Creation of sinus rhythm and paced maps using a single acquisition step: the "one acquisition-two maps" technique-a feasibility study. 61
32562193 2020
15
Electrocardiographic Findings in COVID-19: Insights on Mortality and Underlying Myocardial Processes. 61
32544622 2020
16
The heart in m.3243A>G carriers. 61
30128910 2020
17
QTc interval evaluation in patients with right bundle branch block or bifascicular blocks. 61
32427380 2020
18
A case of incessant bundle branch reentry tachycardia occurring after phase 3 right bundle branch block as a first manifestation of left ventricular noncompaction cardiomyopathy in a patient with bicuspid aortic valve. 61
32461894 2020
19
Keeping pace with the competition: His bundle versus biventricular pacing in heart failure. 61
32205478 2020
20
New-onset intrinsic and paced QRS morphology of right bundle branch block pattern after atrioventricular nodal ablation: Longitudinal dissociation or anatomical bifurcation? 61
32249456 2020
21
Evaluation of the incidence, timing, and potential recovery rates of complete atrioventricular block after transcatheter aortic valve implantation: a Japanese multicenter registry study. 61
32418052 2020
22
Elaborate evaluation of serial changes in electrocardiograms of atrial septal defects after transcatheter closure for a better understanding of the recovery process. 61
32468142 2020
23
Impact of Left Ventricular Outflow Tract Calcification on Pacemaker Implantation After Transcatheter Aortic Valve Implantation With Second-Generation Devices. 61
32045345 2020
24
Unique features of epicardial ventricular arrhythmias/premature ventricular complexes ablated from coronary venous system in veteran population. 61
32081685 2020
25
Validation of scoring system predicting permanent pacemaker implantation after transcatheter aortic valve replacement. 61
32270881 2020
26
Effect of transcatheter closure by AmplatzerTM Duct Occluder II in patients with small ventricular septal defect. 61
32462466 2020
27
Tachyarrhythmia discriminator for implantable cardioverter-defibrillators in bundle branch block. 61
32353586 2020
28
Electrical and mechanical dyssynchrony in patients with right bundle branch block. 61
30143955 2020
29
Electrical and mechanical dyssynchrony in patients with right bundle branch block. 61
30298370 2020
30
The impact of right bundle branch block on right ventricular size and function assessed by three-dimensional speckle-tracking echocardiography. 61
31630228 2020
31
Ventricular arrhythmias and risk stratification of cardiac sudden death in athletes. 61
32429629 2020
32
Arrhythmias in Relation to Mortality After Transcatheter Aortic Valve Replacement. 61
32325047 2020
33
The association of cannabis use and cardiac dysrhythmias: a systematic review. 61
32267189 2020
34
Comparison of measures of ventricular delay on cardiac resynchronization therapy response. 61
31765805 2020
35
Clinical Presentations and Outcomes in Patients Presenting With Acute Cardiac Events and Right Bundle Branch Block. 61
31808355 2020
36
Cardiac resynchronization therapy in a case with single ventricle and concommitant noncompaction cardiomyopathy. 61
32147646 2020
37
Complete atrioventricular block caused by pulmonary embolism: A case report and review of literature. 61
31248624 2020
38
Choose to fly higher rather than pacing around. 61
32159292 2020
39
Impact of the repositionable Evolut R CoreValve system on the need for a permanent pacemaker after transcatheter aortic valve implantation in patients with severe aortic stenosis. 61
31062927 2020
40
Electrocardiographic morphology during left bundle branch area pacing: Characteristics, underlying mechanisms, and clinical implications. 61
32045008 2020
41
An intelligent learning approach for improving ECG signal classification and arrhythmia analysis. 61
32143795 2020
42
Determinants of Sudden Cardiac Death in Adult Patients With Eisenmenger Syndrome. 61
32174228 2020
43
Risk Prediction Model for Cardiac Implantable Electronic Device Implantation After Transcatheter Aortic Valve Replacement. 61
32192680 2020
44
Ventricular Arrhythmias in Myocarditis: Characterization and Relationships With Myocardial Inflammation. 61
32138965 2020
45
Pacemaker implantation after aortic valve replacement: rapid-deployment Intuity® compared to conventional bioprostheses. 61
32215660 2020
46
[Analysis of immunological characteristics of dermatomyositis patients with myocardial involvement]. 61
32192287 2020
47
Assessment of diagnostic accuracy of SanketLife - A wireless, pocket-sized ECG biosensor, in comparison to standard 12 lead ECG in the detection of cardiovascular diseases in a tertiary care setting. 61
31866552 2020
48
Mechanisms of left ventricular dyssynchrony: A multinational SPECT study of patients with bundle branch block. 61
32060855 2020
49
[Brugada syndrome with complete right bundle branch block successfully treated with low dose quinidine: a case report]. 61
32135617 2020
50
Differences in presentation and clinical outcomes between left or right bundle branch block and ST segment elevation in patients with acute myocardial infarction. 61
32030999 2020

Variations for Right Bundle Branch Block

ClinVar genetic disease variations for Right Bundle Branch Block:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 BMPR2 NM_001204.7(BMPR2):c.2948G>A (p.Arg983Gln)SNV Conflicting interpretations of pathogenicity 333652 rs148099152 2:203424500-203424500 2:202559777-202559777

Expression for Right Bundle Branch Block

Search GEO for disease gene expression data for Right Bundle Branch Block.

Pathways for Right Bundle Branch Block

Pathways related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 SCN5A SCN3B SCN2B SCN1B PKP2 DSG4
2
Show member pathways
12.78 SCN5A SCN3B SCN2B SCN1B CACNB2 CACNA1C
3
Show member pathways
12.54 SCN5A SCN3B SCN2B SCN1B RANGRF KCNE3
4
Show member pathways
12.27 SCN5A SCN1B NPPB CACNB2 CACNA1C
5 12.12 KCNE3 KCND3 CACNB2 CACNA1C
6
Show member pathways
11.72 SCN5A SCN3B SCN2B SCN1B
7
Show member pathways
11.43 SCN5A SCN3B SCN2B SCN1B RANGRF KCNE3
8 11.03 SCN5A SCN3B SCN2B SCN1B
9 11.02 SCN5A SCN3B SCN2B SCN1B KCNE3 KCND3

GO Terms for Right Bundle Branch Block

Cellular components related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.37 TRPM4 SCN5A SCN3B SCN2B SCN1B RANGRF
2 integral component of membrane GO:0016021 10.25 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2
3 plasma membrane GO:0005886 10.03 TRPM4 SCN5A SCN3B SCN1B RANGRF PKP2
4 caveola GO:0005901 9.58 SCN5A RANGRF BMPR2
5 sarcolemma GO:0042383 9.56 SCN5A KCND3 CACNB2 CACNA1C
6 T-tubule GO:0030315 9.5 SCN5A SCN1B CACNA1C
7 L-type voltage-gated calcium channel complex GO:1990454 9.48 CACNB2 CACNA1C
8 spanning component of plasma membrane GO:0044214 9.46 TRPM4 BMPR2
9 sodium channel complex GO:0034706 9.37 TRPM4 SCN1B
10 intercalated disc GO:0014704 9.26 SCN5A SCN1B RANGRF PKP2
11 voltage-gated sodium channel complex GO:0001518 8.92 SCN5A SCN3B SCN2B SCN1B

Biological processes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.18 TRPM4 SCN5A SCN3B SCN2B SCN1B KCNE3
2 transmembrane transport GO:0055085 10.07 TRPM4 SCN5A KCND3 HCN4 CACNA1C
3 sodium ion transport GO:0006814 9.97 SCN5A SCN3B SCN2B SCN1B HCN4
4 sodium ion transmembrane transport GO:0035725 9.93 SCN5A SCN3B SCN2B SCN1B HCN4
5 cardiac muscle contraction GO:0060048 9.88 SCN5A SCN3B SCN2B SCN1B
6 cardiac conduction GO:0061337 9.87 TRPM4 SCN5A SCN3B SCN1B KCND3 CACNB2
7 regulation of heart rate GO:0002027 9.85 SCN5A RANGRF HCN4 GPD1L
8 regulation of membrane potential GO:0042391 9.84 TRPM4 RANGRF HCN4
9 regulation of sodium ion transmembrane transporter activity GO:2000649 9.83 SCN3B SCN2B SCN1B RANGRF GPD1L
10 regulation of ion transmembrane transport GO:0034765 9.81 SCN5A SCN3B SCN2B SCN1B KCNE3 KCND3
11 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.8 SCN5A SCN3B SCN2B SCN1B
12 ventricular cardiac muscle cell action potential GO:0086005 9.8 SCN5A SCN3B PKP2 KCNE3 GPD1L
13 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.78 SCN5A SCN1B KCNE3
14 membrane depolarization GO:0051899 9.77 SCN5A SCN3B SCN1B
15 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.77 TRPM4 PKP2 CACNA1C
16 positive regulation of sodium ion transport GO:0010765 9.77 SCN5A SCN3B SCN1B PKP2 GPD1L
17 membrane depolarization during AV node cell action potential GO:0086045 9.76 TRPM4 SCN5A CACNB2 CACNA1C
18 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.74 SCN5A SCN3B GPD1L
19 SA node cell action potential GO:0086015 9.73 SCN5A SCN3B HCN4
20 cardiac muscle cell action potential involved in contraction GO:0086002 9.73 SCN5A SCN3B SCN2B SCN1B PKP2 CACNA1C
21 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.7 SCN5A CACNB2 CACNA1C
22 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.69 TRPM4 SCN5A SCN1B
23 positive regulation of protein localization to cell surface GO:2000010 9.67 RANGRF GPD1L
24 sodium ion import across plasma membrane GO:0098719 9.67 TRPM4 HCN4
25 membrane depolarization during action potential GO:0086010 9.66 SCN5A SCN3B
26 potassium ion export across plasma membrane GO:0097623 9.66 KCNE3 KCND3
27 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.65 PKP2 CACNA1C
28 negative regulation of systemic arterial blood pressure GO:0003085 9.65 NPPB BMPR2
29 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.65 KCNE3 KCND3
30 atrial cardiac muscle cell action potential GO:0086014 9.64 SCN5A SCN3B
31 regulation of sodium ion transmembrane transport GO:1902305 9.64 SCN5A RANGRF
32 regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 9.63 RANGRF HCN4
33 regulation of membrane depolarization GO:0003254 9.63 RANGRF HCN4
34 membrane depolarization during SA node cell action potential GO:0086046 9.62 SCN5A HCN4
35 response to pyrethroid GO:0046684 9.62 SCN2B SCN1B
36 membrane depolarization during bundle of His cell action potential GO:0086048 9.61 TRPM4 SCN5A
37 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.43 SCN5A SCN3B SCN2B SCN1B HCN4 CACNA1C
38 regulation of heart rate by cardiac conduction GO:0086091 9.36 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2

Molecular functions related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.8 TRPM4 SCN5A KCND3 HCN4 CACNA1C
2 calcium channel activity GO:0005262 9.73 TRPM4 CACNB2 CACNA1C
3 sodium channel activity GO:0005272 9.72 SCN5A SCN3B SCN2B SCN1B HCN4
4 potassium channel activity GO:0005267 9.71 KCNE3 KCND3 HCN4
5 voltage-gated potassium channel activity GO:0005249 9.69 KCNE3 KCND3 HCN4
6 voltage-gated sodium channel activity GO:0005248 9.67 SCN5A SCN2B SCN1B HCN4
7 sodium channel regulator activity GO:0017080 9.63 SCN3B SCN2B SCN1B RANGRF PKP2 GPD1L
8 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.56 SCN5A SCN3B SCN2B SCN1B
9 ion channel binding GO:0044325 9.56 SCN5A SCN3B SCN1B RANGRF PKP2 KCNE3
10 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.55 KCNE3 KCND3
11 high voltage-gated calcium channel activity GO:0008331 9.52 CACNB2 CACNA1C
12 sodium channel inhibitor activity GO:0019871 9.49 SCN3B SCN1B
13 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.48 CACNB2 CACNA1C
14 voltage-gated calcium channel activity involved in AV node cell action potential GO:0086056 9.46 CACNB2 CACNA1C
15 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.43 SCN5A SCN1B
16 voltage-gated ion channel activity GO:0005244 9.28 SCN5A SCN3B SCN2B SCN1B KCNE3 KCND3

Sources for Right Bundle Branch Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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