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MCID: RGH001
MIFTS: 47

Right Bundle Branch Block

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Right Bundle Branch Block

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MalaCards integrated aliases for Right Bundle Branch Block:

Name: Right Bundle Branch Block 12 29 54 6 15 71
Right Bundle Branch Block with Left Posterior Fascicular Block 12

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:13209
ICD9CM 34 426.51
SNOMED-CT 67 46319007
UMLS 71 C0085615 C0155704
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Summaries for Right Bundle Branch Block

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MalaCards based summary : Right Bundle Branch Block, also known as right bundle branch block with left posterior fascicular block, is related to progressive familial heart block, type ib and brugada syndrome 1. An important gene associated with Right Bundle Branch Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Developmental Biology and G-Beta Gamma Signaling. The drugs Carvedilol and Enalaprilat have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and kidney, and related phenotype is cardiovascular system.

Wikipedia : 74 A right bundle branch block (RBBB) is a heart block in the right bundle branch of the electrical... more...

Sources

Related Diseases for Right Bundle Branch Block

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Diseases related to Right Bundle Branch Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ib 34.5 TRPM4 SCN5A
2 brugada syndrome 1 33.5 SCN5A KCNH2
3 brugada syndrome 2 32.9 SCN5A GPD1L
4 ventricular fibrillation, paroxysmal familial, 1 32.9 SCN5A KCNH2 CACNA1C
5 brugada syndrome 9 32.9 SCN5A KCND3
6 brugada syndrome 5 32.8 SCN5A SCN1B KCND3
7 brugada syndrome 6 32.6 SCN5A KCNE3
8 brugada syndrome 4 32.1 SCN5A KCNH2 CACNB2 CACNA1C
9 cardiac conduction defect 31.1 SCN5A SCN1B KCNH2
10 inferior myocardial infarction 30.9 NPPB CA5B
11 left bundle branch hemiblock 30.9 SCN5A PKP2 NPPB NACC2 ACE
12 second-degree atrioventricular block 30.8 SCN5A SCN3B HCN4 CA5B
13 congestive heart failure 30.8 SCN5A NPPB CACNA1C ACE
14 wolff-parkinson-white syndrome 30.6 SCN5A NPPB KCNH2
15 atrial standstill 1 30.6 SCN5A SCN1B PKP2 NPPB ACE
16 progressive familial heart block 30.6 TRPM4 SCN5A SCN1B
17 anterolateral myocardial infarction 30.5 NPPB ACE
18 hypertrophic cardiomyopathy 30.4 SCN5A HCN4 CACNB2 CACNA1C ACE
19 sick sinus syndrome 30.4 SCN5A SCN3B SCN1B HCN4 CACNA1C
20 brugada syndrome 30.4 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2
21 atrial heart septal defect 30.4 SCN5A PRODH NPPB BMPR2 ACE
22 patent foramen ovale 30.2 TRPM4 NPPB CACNA1C ACE
23 pulmonary valve insufficiency 30.2 NPPB BMPR2 ACE
24 first-degree atrioventricular block 30.2 SCN5A DSG4 CA5B ACE
25 coronary artery anomaly 30.0 SCN5A NPPB KCNH2 ACE
26 tetralogy of fallot 29.9 SCN5A PRODH NPPB KCNH2 CA5B ACE
27 tricuspid valve insufficiency 29.9 NPPB CA5B BMPR2 ACE
28 cardiac arrhythmia 29.9 SCN5A PKP2 KCNH2 CACNA1C
29 atrioventricular block 29.8 TRPM4 SCN5A NPPB KCNH2 HCN4 CACNA1C
30 cardiac arrest 29.4 TRPM4 SCN5A NPPB KCNH2 HCN4 CACNB2
31 arrhythmogenic right ventricular cardiomyopathy 29.4 TRPM4 SCN5A PKP2 NPPB KCNH2 HCN4
32 sinoatrial node disease 29.3 SCN5A SCN3B SCN1B KCNH2 HCN4 GPD1L
33 third-degree atrioventricular block 29.1 SCN5A SCN1B NPPB HCN4 DSG4 CA5B
34 heart disease 28.7 SCN5A PRODH PKP2 NPPB KCNH2 HCN4
35 atrial fibrillation 28.7 SCN5A SCN3B SCN2B SCN1B NPPB KCNH2
36 dilated cardiomyopathy 28.2 SCN5A SCN2B PKP2 NPPB KCNH2 KCND3
37 long qt syndrome 27.9 TRPM4 SCN5A SCN1B PKP2 KCNH2 KCNE3
38 progressive familial heart block, type ia 12.3
39 brugada syndrome 3 11.5
40 brugada syndrome 7 11.5
41 brugada syndrome 8 11.5
42 acute myocardial infarction 10.8
43 heart septal defect 10.8
44 ventricular septal defect 10.7
45 myocardial infarction 10.7
46 syncope 10.7
47 ischemia 10.5
48 anteroseptal myocardial infarction 10.5
49 pulmonary embolism 10.5
50 cardiogenic shock 10.5

Comorbidity relations with Right Bundle Branch Block via Phenotypic Disease Network (PDN): (show all 27)


Acute Cystitis Aortic Valve Disease 1
Atrioventricular Block Benign Essential Hypertension
Bronchitis Chronic Pulmonary Heart Disease
Deficiency Anemia Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Left Bundle Branch Hemiblock Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Prostatic Hypertrophy Pulmonary Hypertension, Primary, 1
Respiratory Failure Sinoatrial Node Disease
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Tricuspid Valve Disease

Graphical network of the top 20 diseases related to Right Bundle Branch Block:



Diseases related to Right Bundle Branch Block
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Symptoms & Phenotypes for Right Bundle Branch Block

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MGI Mouse Phenotypes related to Right Bundle Branch Block:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.4 ACE BMPR2 CACNA1C CACNB2 HCN4 KCND3
Sources

Drugs & Therapeutics for Right Bundle Branch Block

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Drugs for Right Bundle Branch Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
2
Enalaprilat Approved Phase 4 76420-72-9 6917719
3
Enalapril Approved, Vet_approved Phase 4 75847-73-3 5362032 40466924
4
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
5 Neurotransmitter Agents Phase 4
6 Antihypertensive Agents Phase 4
7 HIV Protease Inhibitors Phase 4
8 Hormones Phase 4
9
protease inhibitors Phase 4
10 Adrenergic Antagonists Phase 4
11 Adrenergic alpha-Antagonists Phase 4
12 Adrenergic beta-Antagonists Phase 4
13 Antioxidants Phase 4
14 Natriuretic Peptide, Brain Phase 4
15 Vasodilator Agents Phase 4
16 Adrenergic Agents Phase 4
17 Protective Agents Phase 4
18 Calcium, Dietary Phase 4
19 calcium channel blockers Phase 4
20 Angiotensin-Converting Enzyme Inhibitors Phase 4
21 Bronchodilator Agents

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Carvedilol After Renin-angiotensin System Inhibition in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
2 Prevention of Early Readmission in Elderly Congestive Heart Failure Patients Completed NCT00000475 Phase 2
3 Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization Unknown status NCT00173342
4 Clinical Profile of Patients With Pulmonary Hypertension Due to Lung Diseases ( Single Center Experience) Unknown status NCT02774928
5 Postoperative Right Bundle Branch Block - Long-term Effect on the Right Ventricle in Children Operated for Ventricular Septal Defect Completed NCT01480908
6 Genetic Architecture of Heart Disease in Rural Brazil Completed NCT00023556
7 Imaging of Ventricular Reversed Remodeling After Double Lung Transplantation in Patients With Pulmonary Arterial Hypertension Completed NCT02391441
8 Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram Completed NCT00453700
9 SL-AF Trial - (Six Lead Identification of Atrial Fibrillation [AF]) Completed NCT02401451
10 Risk of Cardiovascular Disease in Soccer Referees: a Cross Sectional Study Completed NCT03171285
11 Novel Methods for Arrhythmia Detection: Chest Strap ECG and Wrist Band Photoplethysmography Compared to Holter-device for Atrial Fibrillation Detection Completed NCT03721601
12 Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease Completed NCT02315300
13 Biventricular Pacing in Children After Surgery for Congenital Heart Disease Completed NCT02806245
14 Predicting Hypoglycaemia and Arrhythmias in the Vulnerable Patient With Diabetes and Chronic Kidney Disease - Validation Study Completed NCT02778269
15 Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure, a Pilot Clinical Trial (The SPARK Trial) Recruiting NCT02441101
16 Ventricular Electrical Synchronization by Stimulating Left and Right Bundle Branches Area in Pacing-indicated Patients Recruiting NCT04023890
17 Permanent Left Bundle Branch Area Pacing for Atrioventricular Block Recruiting NCT03851315
18 Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction Recruiting NCT03524001
19 Chest Strap and PPG-device Compared to Holter-device for Atrial Fibrillation Detection: 24 Hour Study Recruiting NCT03507335
20 Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following Transcatheter Aortic Valve Replacement. The PROMOTE Study Not yet recruiting NCT04139616
21 Right Ventricular Pacing to Treat Right Ventricular Failure: A Single Arm Hemodynamic Study Not yet recruiting NCT04194632
22 Pacing Affects Cardiovascular Endpoints in Patients With Right Bundle-Branch Block (The PACE-RBBB Trial) Terminated NCT01169493

Search NIH Clinical Center for Right Bundle Branch Block

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Genetic Tests for Right Bundle Branch Block

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Genetic tests related to Right Bundle Branch Block:

# Genetic test Affiliating Genes
1 Right Bundle Branch Block 29
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Anatomical Context for Right Bundle Branch Block

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MalaCards organs/tissues related to Right Bundle Branch Block:

40
Heart, Testes, Kidney, Lung, Spinal Cord, Brain, Atrioventricular Node
Sources

Publications for Right Bundle Branch Block

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Articles related to Right Bundle Branch Block:

(show top 50) (show all 3308)
# Title Authors PMID Year
1
Brugada disease: chronology of discovery and paternity. Preliminary observations and historical aspects. 54 61
16943925 2003
2
A novel SCN5A mutation associated with idiopathic ventricular fibrillation without typical ECG findings of Brugada syndrome. 54 61
10940383 2000
3
Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. 54 61
10662748 2000
4
Clinical Presentations and Outcomes in Patients Presenting With Acute Cardiac Events and Right Bundle Branch Block. 61
31808355 2020
5
Early Repolarization Pattern and Left Ventricular Mass in Hypertrophic Cardiomyopathy. 61
32018270 2020
6
Differences in presentation and clinical outcomes between left or right bundle branch block and ST segment elevation in patients with acute myocardial infarction. 61
32030999 2020
7
Transient high-degree right bundle branch block masking the type 1 Brugada ECG pattern associated with possible transient early repolarization syndrome. 61
31343106 2020
8
New-onset complete right bundle branch block following successful balloon mitral valvuloplasty for mitral stenosis: a new phenomenon? 61
31948980 2020
9
Arrhythmogenic Left Ventricular Cardiomyopathy: A Clinical and CMR Study. 61
31953454 2020
10
Bidirectional Ventricular Tachycardia in a Women with Dilated Cardiomyopathy: A Case Report. 61
31938781 2020
11
Myocardial work is a predictor of exercise tolerance in patients with dilated cardiomyopathy and left ventricular dyssynchrony. 61
31515694 2020
12
Prognostic value of the 12-lead surface electrocardiogram in sarcomeric hypertrophic cardiomyopathy: data from the REMY French register. 61
31603495 2020
13
Rare Association of Takotsubo Cardiomyopathy with Right Bundle Branch Block in the Dual Setting of Asthma Exacerbation and Psychiatric Illness. 61
31959739 2020
14
Incidence and Predictors of Permanent Pacemaker Implantation in Patients Who Underwent Transcatheter Aortic Valve Replacement: Observation of a Chinese Population. 61
31722361 2020
15
Novel ultra-high-frequency electrocardiogram tool for the description of the ventricular depolarization pattern before and during cardiac resynchronization. 61
31788894 2020
16
Severe chronic kidney disease is associated with poor survival after initial CRT-defibrillator tachyarrhythmia therapy. 61
31674681 2020
17
Electrophysiological parameters and anatomical evaluation of left bundle branch pacing in an in vivo canine model. 61
31778271 2020
18
Typical BBB morphology and implantation depth of 3830 electrode predict QRS correction by left bundle branch area pacing. 61
31773756 2020
19
Late onset of new conduction disturbances requiring permanent pacemaker implantation following TAVI. 61
32005676 2020
20
Remifentanil-Induced Transient Right Bundle Branch Block During Hemorrhoidectomy 61
31726805 2019
21
Right Bundle Branch Block in Patients Undergoing Transcatheter Aortic Valve Implantation: Are There Clinical Implications? 61
31814348 2019
22
Resolution of right bundle branch block after a premature ventricular beat: What is the mechanism? 61
31890585 2019
23
The Utility of Prophylactic Pacemaker Implantation in Right Bundle Branch Block Patients Pre-Transcatheter Aortic Valve Implantation. 61
31814341 2019
24
The QR-max index, a novel electrocardiographic index for the determination of left ventricular conduction delay and selection of cardiac resynchronization in patients with non-left bundle branch block. 61
31807986 2019
25
[Transcatheter aortic valve implantation and conduction disturbances]. 61
31668339 2019
26
Late ventricular standstill following an elective TAVI. 61
31852692 2019
27
Assessment of diagnostic accuracy of SanketLife - A wireless, pocket-sized ECG biosensor, in comparison to standard 12 lead ECG in the detection of cardiovascular diseases in a tertiary care setting. 61
31866552 2019
28
Arrhythmias in Severe Trazodone Overdose. 61
31879415 2019
29
The Evolving Role of Electrocardiography in Cardiac Resynchronization Therapy. 61
31828564 2019
30
Electrical parameters with His-bundle pacing: Considerations for automated programming. 61
31377421 2019
31
Wide QRS tachycardia associated with multiple accessory pathways in a patient with Wolff-Parkinson-White syndrome. 61
31762831 2019
32
Utility of 30-Day Continuous Ambulatory Monitoring to Identify Patients With Delayed Occurrence of Atrioventricular Block After Transcatheter Aortic Valve Replacement. 61
31833417 2019
33
Permanent left bundle branch area pacing for atrioventricular block: Feasibility, safety, and acute effect. 61
31048065 2019
34
Prospective evaluation of feasibility and electrophysiologic and echocardiographic characteristics of left bundle branch area pacing. 61
31136869 2019
35
Prognostic Value of Electrocardiography in Elderly Patients with Acute Pulmonary Embolism. 61
31247179 2019
36
Audit of a cardiac screening policy for elite Australian cricketers. 61
31956043 2019
37
A pacemaker lead in the left ventricle: An "unexpected" finding? 61
31762840 2019
38
Evaluation of mortality in bundle branch block patients from an electronic cohort: Clinical Outcomes in Digital Electrocardiography (CODE) study. 61
31653433 2019
39
[Complete heart block: A rare central venous catheter placement complication]. 61
31919328 2019
40
Left bundle branch pacing from distal His-bundle region by tricuspid valve annulus angiography. 61
31544273 2019
41
Pacemaker dependency after transcatheter aortic valve implantation: incidence, predictors and long-term outcomes. 61
31217147 2019
42
The yield of long-term electrocardiographic recordings in refractory focal epilepsy. 61
31637707 2019
43
Comparison of measures of ventricular delay on cardiac resynchronization therapy response. 61
31765805 2019
44
Pacemaker Implantation and Dependency After Transcatheter Aortic Valve Replacement in the REPRISE III Trial. 61
31640455 2019
45
Development of a Risk Score to Predict New Pacemaker Implantation After Transcatheter Aortic Valve Replacement. 61
31699374 2019
46
The impact of right bundle branch block on right ventricular size and function assessed by three-dimensional speckle-tracking echocardiography. 61
31630228 2019
47
Cardiac memory-related QT prolongation during right bundle-branch block in a patient with pre-existing left bundle-branch block. 61
31478279 2019
48
One-Year Follow-Up of Conduction Abnormalities After Transcatheter Aortic Valve Implantation With the SAPIEN 3 Valve. 61
31439281 2019
49
Characteristics and Prevalence of Premature Ventricular Complex: A Telemedicine Study. 61
31636796 2019
50
Atypical Electrocardiographic Presentations in Need of Primary Percutaneous Coronary Intervention. 61
31455501 2019
Sources

Variations for Right Bundle Branch Block

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ClinVar genetic disease variations for Right Bundle Branch Block:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 BMPR2 NM_001204.7(BMPR2):c.2948G>A (p.Arg983Gln)SNV Likely benign 333652 rs148099152 2:203424500-203424500 2:202559777-202559777
Sources

Expression for Right Bundle Branch Block

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Search GEO for disease gene expression data for Right Bundle Branch Block.
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Pathways for Right Bundle Branch Block

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Pathways related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 13.29 SCN5A SCN3B SCN2B SCN1B PKP2 DSG4
2
G-Beta Gamma Signaling 63
Show member pathways
 12.8 SCN5A SCN3B SCN2B SCN1B CACNB2 CACNA1C
3
Cardiac conduction 65
Show member pathways
 12.54 SCN5A SCN3B SCN2B SCN1B KCNH2 KCNE3
4
cGMP-PKG signaling pathway 36
Show member pathways
 12.3 SCN5A SCN1B NPPB CACNB2 CACNA1C
5
Dopamine-DARPP32 Feedback onto cAMP Pathway 63
12.08 KCNH2 KCNE3 KCND3 CACNB2 CACNA1C
6
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.94 SCN5A SCN3B KCNH2 GPD1L
7
L1CAM interactions 65
Show member pathways
 11.77 SCN5A SCN3B SCN2B SCN1B
8
Phase 0 - rapid depolarisation 65
Show member pathways
 11.37 SCN5A SCN3B SCN2B SCN1B KCNE3 CACNB2
9
Antiarrhythmic Pathway, Pharmacodynamics 60
11.07 SCN5A SCN3B SCN2B SCN1B KCNH2 KCNE3
10
Interaction between L1 and Ankyrins 65
11.03 SCN5A SCN3B SCN2B SCN1B
Sources

GO Terms for Right Bundle Branch Block

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Cellular components related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.37 TRPM4 SCN5A SCN3B SCN2B SCN1B KCNH2
2 integral component of membrane GO:0016021 10.17 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2
3 plasma membrane GO:0005886 9.83 TRPM4 SCN5A SCN3B SCN1B PKP2 KCNH2
4 voltage-gated potassium channel complex GO:0008076 9.63 KCNH2 KCNE3 KCND3
5 intercalated disc GO:0014704 9.54 SCN5A SCN1B PKP2
6 L-type voltage-gated calcium channel complex GO:1990454 9.48 CACNB2 CACNA1C
7 sarcolemma GO:0042383 9.46 SCN5A KCND3 CACNB2 CACNA1C
8 sodium channel complex GO:0034706 9.43 TRPM4 SCN1B
9 T-tubule GO:0030315 9.43 SCN5A SCN1B CACNA1C
10 spanning component of plasma membrane GO:0044214 9.4 TRPM4 BMPR2
11 voltage-gated sodium channel complex GO:0001518 8.92 SCN5A SCN3B SCN2B SCN1B

Biological processes related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.14 TRPM4 SCN5A SCN3B SCN2B SCN1B KCNH2
2 transmembrane transport GO:0055085 10.13 TRPM4 SCN5A KCNH2 KCND3 HCN4 CACNA1C
3 sodium ion transport GO:0006814 9.98 SCN5A SCN3B SCN2B SCN1B HCN4
4 sodium ion transmembrane transport GO:0035725 9.96 SCN5A SCN3B SCN2B SCN1B HCN4
5 potassium ion transport GO:0006813 9.94 KCNH2 KCNE3 KCND3 HCN4
6 potassium ion transmembrane transport GO:0071805 9.94 KCNH2 KCNE3 KCND3 HCN4
7 cardiac muscle contraction GO:0060048 9.89 SCN5A SCN3B SCN2B SCN1B KCNH2
8 regulation of membrane potential GO:0042391 9.86 TRPM4 KCNH2 HCN4
9 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.85 SCN5A SCN1B KCNH2 KCNE3
10 ventricular cardiac muscle cell action potential GO:0086005 9.85 SCN5A SCN3B PKP2 KCNH2 KCNE3 GPD1L
11 positive regulation of sodium ion transport GO:0010765 9.83 SCN5A SCN3B SCN1B PKP2 GPD1L
12 regulation of heart rate GO:0002027 9.81 SCN5A HCN4 GPD1L
13 regulation of sodium ion transmembrane transporter activity GO:2000649 9.81 SCN3B SCN2B SCN1B GPD1L
14 cardiac muscle cell action potential involved in contraction GO:0086002 9.8 SCN5A SCN3B SCN2B SCN1B PKP2 CACNA1C
15 membrane depolarization GO:0051899 9.79 SCN5A SCN3B SCN1B
16 membrane depolarization during action potential GO:0086010 9.79 SCN5A SCN3B KCNH2
17 potassium ion export across plasma membrane GO:0097623 9.78 KCNH2 KCNE3 KCND3
18 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.78 SCN5A SCN3B SCN2B SCN1B
19 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.77 KCNH2 KCNE3 KCND3
20 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.77 TRPM4 PKP2 CACNA1C
21 membrane depolarization during AV node cell action potential GO:0086045 9.76 TRPM4 SCN5A CACNB2 CACNA1C
22 cardiac conduction GO:0061337 9.76 TRPM4 SCN5A SCN3B SCN1B KCNH2 KCND3
23 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.75 SCN5A SCN3B GPD1L
24 SA node cell action potential GO:0086015 9.74 SCN5A SCN3B HCN4
25 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.73 SCN5A SCN3B SCN2B SCN1B HCN4 CACNA1C
26 membrane depolarization during atrial cardiac muscle cell action potential GO:0098912 9.71 SCN5A CACNB2 CACNA1C
27 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.7 TRPM4 SCN5A SCN1B
28 sodium ion import across plasma membrane GO:0098719 9.68 TRPM4 HCN4
29 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.68 PKP2 CACNA1C
30 negative regulation of systemic arterial blood pressure GO:0003085 9.67 NPPB BMPR2
31 membrane repolarization GO:0086009 9.67 KCNH2 KCND3
32 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.67 KCNH2 KCND3
33 atrial cardiac muscle cell action potential GO:0086014 9.66 SCN5A SCN3B
34 membrane repolarization during action potential GO:0086011 9.66 KCNH2 KCNE3
35 membrane depolarization during SA node cell action potential GO:0086046 9.65 SCN5A HCN4
36 response to pyrethroid GO:0046684 9.65 SCN2B SCN1B
37 regulation of ion transmembrane transport GO:0034765 9.65 SCN5A SCN3B SCN2B SCN1B KCNH2 KCNE3
38 negative regulation of potassium ion export across plasma membrane GO:1903765 9.63 KCNH2 KCNE3
39 membrane depolarization during bundle of His cell action potential GO:0086048 9.62 TRPM4 SCN5A
40 regulation of heart rate by cardiac conduction GO:0086091 9.4 TRPM4 SCN5A SCN3B SCN2B SCN1B PKP2

Molecular functions related to Right Bundle Branch Block according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.8 TRPM4 SCN5A KCNH2 HCN4 CACNA1C
2 potassium channel activity GO:0005267 9.78 KCNH2 KCNE3 KCND3 HCN4
3 sodium channel regulator activity GO:0017080 9.77 SCN3B SCN2B SCN1B PKP2 GPD1L
4 voltage-gated potassium channel activity GO:0005249 9.76 KCNH2 KCNE3 KCND3 HCN4
5 calcium channel activity GO:0005262 9.74 TRPM4 CACNB2 CACNA1C
6 sodium channel activity GO:0005272 9.72 SCN5A SCN3B SCN2B SCN1B HCN4
7 voltage-gated sodium channel activity GO:0005248 9.65 SCN5A SCN3B SCN2B SCN1B HCN4
8 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.61 KCNH2 KCNE3 KCND3
9 high voltage-gated calcium channel activity GO:0008331 9.56 CACNB2 CACNA1C
10 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.55 KCNH2 KCND3
11 sodium channel inhibitor activity GO:0019871 9.54 SCN3B SCN1B
12 voltage-gated calcium channel activity involved in cardiac muscle cell action potential GO:0086007 9.52 CACNB2 CACNA1C
13 voltage-gated calcium channel activity involved in AV node cell action potential GO:0086056 9.51 CACNB2 CACNA1C
14 ion channel binding GO:0044325 9.5 SCN5A SCN3B SCN1B PKP2 KCNE3 KCND3
15 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.49 SCN5A SCN1B
16 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.46 SCN5A SCN3B SCN2B SCN1B
17 voltage-gated ion channel activity GO:0005244 9.23 SCN5A SCN3B SCN2B SCN1B KCNH2 KCND3
Sources

Sources for Right Bundle Branch Block

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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