SSSS
MCID: RTT001
MIFTS: 45

Ritter's Disease (SSSS)

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Ritter's Disease

MalaCards integrated aliases for Ritter's Disease:

Name: Ritter's Disease 12 15
Staphylococcal Scalded Skin Syndrome 12 76 59 55 44 73
Pemphigus Neonatorum 12 73
Toxic Epidermal Necrolysis, Subcorneal Type 12
Dermatitis Exfoliativa Neonatorum 12
Generalized Exfoliative Disease 59
Scalded Skin Syndrome 12
Ritter Disease 12
Ssss 59

Characteristics:

Orphanet epidemiological data:

59
staphylococcal scalded skin syndrome
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9063
ICD10 33 L00
ICD9CM 35 695.81
MeSH 44 D013206
NCIt 50 C85077
SNOMED-CT 68 87758007
Orphanet 59 ORPHA36236
MESH via Orphanet 45 D013206
UMLS via Orphanet 74 C0038165
ICD10 via Orphanet 34 L00

Summaries for Ritter's Disease

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has symptoms redness of skin, has symptom fluid-filled blister formation, has symptom fever and has symptom irritability.

MalaCards based summary : Ritter's Disease, also known as staphylococcal scalded skin syndrome, is related to pemphigus foliaceus and bullous impetigo, and has symptoms including fever, irritability and fluid-filled blister formation. An important gene associated with Ritter's Disease is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Keratinization and Apoptotic cleavage of cellular proteins. The drugs Anti-Infective Agents and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and colon, and related phenotypes are integument and vision/eye

Wikipedia : 76 Staphylococcal scalded skin syndrome (SSSS), also known as pemphigus neonatorum or Ritter''s disease, or... more...

Related Diseases for Ritter's Disease

Diseases related to Ritter's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 pemphigus foliaceus 30.5 DSG1 DSG2
2 bullous impetigo 30.5 DSG1 EDNRA EDNRB
3 pemphigus 30.1 DSG1 DSG2 DSG4
4 impetigo 29.7 DSG1 EDNRB HSF4
5 ichthyosis bullosa of siemens 11.1
6 recessive dystrophic epidermolysis bullosa-generalized other 11.1
7 dermatitis 10.7
8 mastocytosis 10.2
9 erythema multiforme 10.1
10 toxic shock syndrome 10.1
11 pyomyositis 10.1
12 homologous wasting disease 10.1
13 commensal bacterial infectious disease 10.0 DSG1 EDNRB
14 perinephritis 10.0 EDNRA EDNRB
15 radiation proctitis 10.0 EDNRA EDNRB
16 paraneoplastic pemphigus 10.0 DSG1 DSG2
17 cystic kidney disease 10.0 EDNRA EDNRB
18 hypotrichosis 9.9 DSG1 DSG4
19 autosomal dominant polycystic kidney disease 9.9 EDNRA EDNRB
20 epidermolytic hyperkeratosis 9.9
21 retinoblastoma 9.9
22 small cell cancer of the lung 9.9
23 lung cancer 9.9
24 netherton syndrome 9.9
25 congenital hemidysplasia with ichthyosiform erythroderma and limb defects 9.9
26 dermatitis herpetiformis, familial 9.9
27 dermatitis, atopic 9.9
28 severe cutaneous adverse reaction 9.9
29 kawasaki disease 9.9
30 psoriasis 14, pustular 9.9
31 arthritis 9.9
32 lymphoma 9.9
33 endocarditis 9.9
34 miliaria rubra 9.9
35 miliaria 9.9
36 epidermolysis bullosa 9.9
37 bilirubin metabolic disorder 9.9
38 septic arthritis 9.9
39 dermatitis herpetiformis 9.9
40 molluscum contagiosum 9.9
41 psoriasis 9.9
42 ophthalmia neonatorum 9.9
43 pustular psoriasis 9.9
44 autosomal dominant epidermolytic ichthyosis 9.9
45 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.9
46 migraine with or without aura 1 9.9 EDNRA EDNRB
47 connective tissue disease 9.8 EDNRA EDNRB
48 pemphigus vulgaris 9.8 DSG1 DSG2 DSG4
49 scarlet fever 9.7 EDNRA EDNRB HSF4

Graphical network of the top 20 diseases related to Ritter's Disease:



Diseases related to Ritter's Disease

Symptoms & Phenotypes for Ritter's Disease

Symptoms:

12
  • fever
  • irritability
  • fluid-filled blister formation

MGI Mouse Phenotypes related to Ritter's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 DSG1 DSG4 EDNRA EDNRB
2 vision/eye MP:0005391 8.92 DSG1 EDNRA EDNRB HSF4

Drugs & Therapeutics for Ritter's Disease

Drugs for Ritter's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents
2 Anti-Bacterial Agents
3 methicillin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276

Search NIH Clinical Center for Ritter's Disease

Cochrane evidence based reviews: staphylococcal scalded skin syndrome

Genetic Tests for Ritter's Disease

Anatomical Context for Ritter's Disease

MalaCards organs/tissues related to Ritter's Disease:

41
Skin, Bone, Colon, Lung, Liver, Bone Marrow, Kidney

Publications for Ritter's Disease

Articles related to Ritter's Disease:

(show top 50) (show all 256)
# Title Authors Year
1
A Unique Pattern of Staphylococcal Scalded Skin Syndrome-Like Erosions in Patients with Atopic Dermatitis: Dermatitis flammeus. ( 30413224 )
2018
2
Adult Staphylococcal Scalded Skin Syndrome Successfully Treated with Multimodal Therapy Including Intravenous Immunoglobulin. ( 28815266 )
2018
3
Staphylococcal Scalded Skin Syndrome Caused by a Rare Variant of Exfoliative-toxin-A+ S. aureus in an Adult Immunocompromised Woman. ( 28853493 )
2018
4
Epidemiology of staphylococcal scalded skin syndrome in U.S. children. ( 29077993 )
2018
5
Staphylococcal scalded skin syndrome: An uncommon symptomatology revealing an immune deficiency. ( 29248323 )
2018
6
Staphylococcal scalded skin syndrome: A pediatric dermatology case report. ( 29326825 )
2018
7
Epidemiology of staphylococcal scalded skin syndrome in the United States: A cross-sectional study, 2010-2014. ( 29332709 )
2018
8
Staphylococcal scalded skin syndrome in a 4-year-old child: a case report. ( 29378637 )
2018
9
Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management. ( 29508362 )
2018
10
Epidemiology of staphylococcal scalded skin syndrome in US adults. ( 29902545 )
2018
11
Variation in Diagnostic Test Use and Associated Outcomes in Staphylococcal Scalded Skin Syndrome at Children's Hospitals. ( 30139766 )
2018
12
Emergence of staphylococcal scalded skin syndrome associated with a new toxinogenic, methicillin-susceptible Staphylococcus aureus clone. ( 30418106 )
2018
13
Rapid containment of nosocomial transmission of a rare community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone, responsible for the Staphylococcal Scalded Skin Syndrome (SSSS). ( 28061866 )
2017
14
Staphylococcal scalded skin syndrome in an extremely preterm newborn: management in a neonatal intensive care unit. ( 28292962 )
2017
15
Recurrent Staphylococcal Scalded Skin Syndrome in an Extremely Low-Birth-Weight Neonate. ( 28674637 )
2017
16
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. ( 26603272 )
2016
17
Adult case of staphylococcal scalded skin syndrome differentiated from toxic epidermal necrolysis with the aid of dermoscopy. ( 26825551 )
2016
18
Staphylococcal Scalded Skin Syndrome: A Case Review. ( 26842534 )
2016
19
Severe case of staphylococcal scalded skin syndrome in a 5-year-old child - case report. ( 27099742 )
2016
20
Demographic and clinical characteristics and risk factors for Staphylococcal scalded skin syndrome in Hunan. ( 27241154 )
2016
21
A Systemic Review on Staphylococcal Scalded Skin Syndrome (SSSS): A Rare and Critical Disease of Neonates. ( 27651848 )
2016
22
Staphylococcal Scalded Skin Syndrome. ( 27771692 )
2016
23
Recognizing staphylococcal scalded skin syndrome. ( 27875404 )
2016
24
Long-term persistence of sequence type 89 methicillin-resistant Staphylococcus aureus isolated from cases of staphylococcal scalded skin syndrome in a Korean community. ( 27902366 )
2016
25
Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature. ( 29967859 )
2016
26
A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography. ( 25580955 )
2015
27
Effective Treatment of Staphylococcal Scalded Skin Syndrome with Platelet Microbicidal Protein in CBRB-Rb(8.17)1Iem Mice Model. ( 26044057 )
2015
28
Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants. ( 25194957 )
2015
29
Coexistence of staphylococcal scalded skin syndrome and acute graft-vs-host disease. ( 25337929 )
2015
30
Adult staphylococcal scalded skin syndrome successfully treated with plasma exchange. ( 25519855 )
2015
31
Staphylococcal scalded skin syndrome in an adult, immunocompetent patient. ( 25701548 )
2015
32
Staphylococcal Scalded Skin Syndrome in Neonate. ( 26167309 )
2015
33
Staphylococcal scalded skin syndrome in a premature newborn caused by methicillin-resistant Staphylococcus aureus: case report. ( 26648436 )
2015
34
Staphylococcal scalded skin syndrome in pregnancy. ( 26682300 )
2015
35
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. ( 25298068 )
2014
36
Staphylococcal scalded skin syndrome in neonates: an 8-year retrospective study in a single institution. ( 23557104 )
2014
37
Antibiotic sensitivity and resistance patterns in pediatric staphylococcal scalded skin syndrome. ( 24033633 )
2014
38
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults. ( 24841497 )
2014
39
Staphylococcal scalded skin syndrome in an immunocompetent adult, clinically mimicking toxic epidermal necrolysis. ( 25041582 )
2014
40
Staphylococcal Scalded Skin Syndrome in an Adult on Chemotherapy. ( 27047925 )
2014
41
A desquamating rash; staphylococcal scalded skin syndrome. ( 23260687 )
2013
42
Staphylococcal scalded skin syndrome. ( 23761500 )
2013
43
Mild staphylococcal scalded skin syndrome: an underdiagnosed clinical disorder. ( 21729032 )
2012
44
Staphylococcal scalded skin syndrome in the Czech Republic: an epidemiological study. ( 22035884 )
2012
45
Varicella infection in a neonate with subsequent staphylococcal scalded skin syndrome and fatal shock. ( 22854238 )
2012
46
Epidemiological data of staphylococcal scalded skin syndrome in France from 1997 to 2007 and microbiological characteristics of Staphylococcus aureus associated strains. ( 23078129 )
2012
47
Staphylococcal scalded skin syndrome due to burn wound infection. ( 23467312 )
2012
48
Nosocomial Staphylococcal scalded skin syndrome caused by intra-articular injection. ( 20579227 )
2011
49
Staphylococcal scalded skin syndrome in an extremely low-birth-weight neonate: molecular characterization and rapid detection by multiplex and real-time PCR of methicillin-resistant Staphylococcus aureus. ( 20831651 )
2011
50
Use of skin substitute dressings in the treatment of staphylococcal scalded skin syndrome in neonates and young infants. ( 21150225 )
2011

Variations for Ritter's Disease

Expression for Ritter's Disease

Search GEO for disease gene expression data for Ritter's Disease.

Pathways for Ritter's Disease

Pathways related to Ritter's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 DSG1 DSG2 DSG4
2
Show member pathways
11.39 DSG1 DSG2
3 10.98 EDNRA EDNRB
4 10.49 EDNRA EDNRB
5 10.1 EDNRA EDNRB

GO Terms for Ritter's Disease

Cellular components related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.16 DSG1 DSG2
2 cornified envelope GO:0001533 9.13 DSG1 DSG2 DSG4
3 desmosome GO:0030057 8.8 DSG1 DSG2 DSG4

Biological processes related to Ritter's Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.65 DSG1 DSG2 DSG4
2 keratinization GO:0031424 9.54 DSG1 DSG2 DSG4
3 cell-cell adhesion GO:0098609 9.49 DSG1 DSG4
4 regulation of blood pressure GO:0008217 9.46 EDNRA EDNRB
5 response to progesterone GO:0032570 9.43 DSG1 DSG2
6 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.43 DSG1 DSG2 DSG4
7 maternal process involved in female pregnancy GO:0060135 9.4 DSG1 DSG2
8 vasoconstriction GO:0042310 9.32 EDNRA EDNRB
9 enteric nervous system development GO:0048484 9.16 EDNRA EDNRB
10 cornification GO:0070268 9.13 DSG1 DSG2 DSG4
11 endothelin receptor signaling pathway GO:0086100 8.62 EDNRA EDNRB

Molecular functions related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.13 DSG1 DSG2 DSG4
2 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Ritter's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....