MCID: RTT001
MIFTS: 41

Ritter's Disease

Categories: Skin diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Ritter's Disease

MalaCards integrated aliases for Ritter's Disease:

Name: Ritter's Disease 12 15
Staphylococcal Scalded Skin Syndrome 12 76 59 55 44 73
Pemphigus Neonatorum 12 73
Toxic Epidermal Necrolysis, Subcorneal Type 12
Dermatitis Exfoliativa Neonatorum 12
Generalized Exfoliative Disease 59
Scalded Skin Syndrome 12
Ritter Disease 12
Ssss 59

Characteristics:

Orphanet epidemiological data:

59
staphylococcal scalded skin syndrome
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9063
ICD10 33 L00
ICD9CM 35 695.81
MeSH 44 D013206
NCIt 50 C85077
Orphanet 59 ORPHA36236
MESH via Orphanet 45 D013206
UMLS via Orphanet 74 C0038165
ICD10 via Orphanet 34 L00

Summaries for Ritter's Disease

Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has symptoms redness of skin, has symptom fluid-filled blister formation, has symptom fever and has symptom irritability.

MalaCards based summary : Ritter's Disease, also known as staphylococcal scalded skin syndrome, is related to pemphigus foliaceus and bullous impetigo, and has symptoms including fluid-filled blister formation, fever and irritability. An important gene associated with Ritter's Disease is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Keratinization and Apoptotic cleavage of cellular proteins. The drugs methicillin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin and colon, and related phenotypes are integument and vision/eye

Wikipedia : 76 Staphylococcal scalded skin syndrome (SSSS), also known as pemphigus neonatorum or Ritter\'s disease, or... more...

Related Diseases for Ritter's Disease

Graphical network of the top 20 diseases related to Ritter's Disease:



Diseases related to Ritter's Disease

Symptoms & Phenotypes for Ritter's Disease

Symptoms:

12
  • fluid-filled blister formation
  • fever
  • irritability

MGI Mouse Phenotypes related to Ritter's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 DSG1 DSG4 EDNRA EDNRB
2 vision/eye MP:0005391 8.92 DSG1 EDNRA EDNRB HSF4

Drugs & Therapeutics for Ritter's Disease

Drugs for Ritter's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 methicillin
2 Anti-Bacterial Agents
3 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Underlying Mechanisms For S. Aureus Infection And Colonization Of Skin in People With Atopic Dermatitis With And Without Eczema Herpeticum (MRSA) Completed NCT00822276

Search NIH Clinical Center for Ritter's Disease

Cochrane evidence based reviews: staphylococcal scalded skin syndrome

Genetic Tests for Ritter's Disease

Anatomical Context for Ritter's Disease

MalaCards organs/tissues related to Ritter's Disease:

41
Skin, Colon

Publications for Ritter's Disease

Articles related to Ritter's Disease:

(show top 50) (show all 58)
# Title Authors Year
1
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. ( 26603272 )
2016
2
A case report of differentiating staphylococcal scalded skin syndrome and toxic epidermal necrolysis by optical coherence tomography. ( 25580955 )
2015
3
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. ( 25298068 )
2014
4
Bullous congenital ichthyosiform erythroderma clinically resembling neonatal staphylococcal scalded skin syndrome. ( 19635120 )
2009
5
Cytokine and nitric oxide production in an adult patient with staphylococcal scalded skin syndrome. ( 19245172 )
2008
6
[Atypical staphylococcal scalded skin syndrome: it could be battered child syndrome]. ( 18610724 )
2008
7
Staphylococcal scalded skin syndrome and toxic shock syndrome after tooth extraction. ( 18485528 )
2008
8
Staphylococcal scalded skin syndrome as a complication of septic arthritis. ( 17714529 )
2007
9
Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome. ( 16757607 )
2006
10
Diagnostic dilemma: extremely low birth weight baby with staphylococcal scalded-skin syndrome or toxic epidermal necrolysis. ( 17066068 )
2006
11
Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome. ( 17065642 )
2006
12
Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins. ( 15815014 )
2005
13
Molluscum contagiosum prevents progression of staphylococcal scalded skin syndrome. ( 16091916 )
2005
14
Netherton syndrome: report of two Taiwanese siblings with staphylococcal scalded skin syndrome and mutation of SPINK5. ( 15656819 )
2005
15
Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome. ( 15545999 )
2004
16
Treatment of bullous impetigo and the staphylococcal scalded skin syndrome in infants. ( 15482208 )
2004
17
Miliaria crystallina complicating staphylococcal scalded skin syndrome. ( 14709532 )
2004
18
Staphylococcal scalded skin syndrome complicating acute generalized pustular psoriasis. ( 12121398 )
2002
19
Staphylococcal scalded skin syndrome related to an exfoliative toxin A- and B-producing strain in preterm infants. ( 12447663 )
2002
20
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. ( 12093888 )
2002
21
Recent developments in staphylococcal scalded skin syndrome. ( 11442563 )
2001
22
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. ( 11062541 )
2000
23
Staphylococcal scalded skin syndrome: exfoliative toxin A (ETA) induces serine protease activity when combined with A431 cells. ( 10447140 )
1999
24
Toxin involvement in staphylococcal scalded skin syndrome. ( 9431380 )
1997
25
Stevens-Johnson syndrome, epidermolysis bullosa, staphylococcal scalded skin syndrome, and dermatitis herpetiformis. ( 9269599 )
1997
26
[Immunological investigations on pathogenesis of staphylococcal scalded skin syndrome]. ( 7602798 )
1995
27
Pyomyositis and staphylococcal scalded skin syndrome. ( 8453207 )
1993
28
Picture of the month. Ritter's disease (neonatal staphylococcal scalded skin syndrome). ( 1558075 )
1992
29
Diffuse cutaneous mastocytosis mimicking staphylococcal scalded-skin syndrome: report of three cases. ( 1923984 )
1991
30
Nosocomial scalded skin syndrome. Ritter's disease caused by phage group 3 Staphylococcus aureus. ( 6449146 )
1980
31
Staphylococcal ophthalmia neonatorum and the staphylococcal scalded skin syndrome. ( 517609 )
1979
32
Atopic dermatitis and Ritter's disease: differential diagnosis by means of total and specific serum IgE. ( 147160 )
1978
33
Staphylococcal scalded skin syndrome. II. Serum level of anti exfoliatin and anti alpha-toxin in patients with staphylococcal scalded skin syndrome or bullous impetigo. ( 15461328 )
1977
34
Toxic epidermal necrolysis (TEN; Ritter's disease) and staphylococcal scalded skin syndrome (SSSS). A description and review. ( 780034 )
1976
35
Total and specific IgE levels as a means of differentiating Ritter's disease from atopic dermatitis. ( 127536 )
1975
36
New type of exfoliatin obtained from staphylococcal strains, belonging to phage groups other than group II, isolated from patients with impetigo and Ritter's disease. ( 4139120 )
1974
37
Epidemic boric acid poisoning simulating staphylococcal toxic epidermal necrolysis of the newborn infant: Ritter's disease. ( 4251286 )
1970
38
Haemolysin and enzyme patterns of coagulase-positive staphylococci isolated from toxic epidermal necrolysis, Ritter's disease and impetigo contagiosa. ( 4252396 )
1969
39
Toxic epidermal necrolysis (the scalded skin syndrome). Its association in two cases with pathogenic staphylococci and its similarity in infancy to Ritter's disease. ( 4222069 )
1966
40
RITTER'S DISEASE. ( 14291657 )
1965
41
Epidemic staphylococcal pyoderma associated with Ritter's disease and the appearance of phage type 3B/71. ( 13975789 )
1963
42
Ritter's disease: exfoliative dermatitis of the newborn. ( 13869919 )
1962
43
An outbreak of exfoliative dermatitis of the newborn (Ritter's disease) due to Staphylococcus aureus, phage-type 55/71. ( 13867356 )
1962
44
An outbreak of Ritter's disease. ( 13763310 )
1961
45
Some interesting but rare disorders seen in pediatric practice with case report of Ritter's disease with recovery. ( 13502281 )
1958
46
Ritter's disease (dermatitis exfoliativa neonatorum) with recovery. ( 13464996 )
1957
47
Dermatitis exfoliativa neonatorum; Ritter's disease. ( 13468377 )
1957
48
Ritter's disease with recovery. ( 13166184 )
1954
49
Impetigo and acute infectious exfoliative dermatitis of the newborn infant (Ritter's disease). ( 14955740 )
1952
50
Ritter's disease and sclerema; report on two rare cases in infants. ( 14921951 )
1952

Variations for Ritter's Disease

Expression for Ritter's Disease

Search GEO for disease gene expression data for Ritter's Disease.

Pathways for Ritter's Disease

Pathways related to Ritter's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.79 DSG1 DSG2 DSG4
2
Show member pathways
11.39 DSG1 DSG2
3 10.98 EDNRA EDNRB
4 10.49 EDNRA EDNRB
5 10.1 EDNRA EDNRB

GO Terms for Ritter's Disease

Cellular components related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral plasma membrane GO:0016328 9.16 DSG1 DSG2
2 cornified envelope GO:0001533 9.13 DSG1 DSG2 DSG4
3 desmosome GO:0030057 8.8 DSG1 DSG2 DSG4

Biological processes related to Ritter's Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.65 DSG1 DSG2 DSG4
2 keratinization GO:0031424 9.54 DSG1 DSG2 DSG4
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.51 EDNRA EDNRB
4 cell-cell adhesion GO:0098609 9.49 DSG1 DSG4
5 regulation of blood pressure GO:0008217 9.46 EDNRA EDNRB
6 response to progesterone GO:0032570 9.43 DSG1 DSG2
7 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.43 DSG1 DSG2 DSG4
8 maternal process involved in female pregnancy GO:0060135 9.4 DSG1 DSG2
9 vasoconstriction GO:0042310 9.32 EDNRA EDNRB
10 enteric nervous system development GO:0048484 9.16 EDNRA EDNRB
11 cornification GO:0070268 9.13 DSG1 DSG2 DSG4
12 endothelin receptor signaling pathway GO:0086100 8.62 EDNRA EDNRB

Molecular functions related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.13 DSG1 DSG2 DSG4
2 endothelin receptor activity GO:0004962 8.62 EDNRA EDNRB

Sources for Ritter's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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