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SSSS
MCID: RTT001
MIFTS: 42

Ritter's Disease (SSSS)

Categories: Infectious diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Ritter's Disease

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MalaCards integrated aliases for Ritter's Disease:

Name: Ritter's Disease 12 15 17
Staphylococcal Scalded Skin Syndrome 12 74 58 54 44 71 32
Pemphigus Neonatorum 12 71
Toxic Epidermal Necrolysis, Subcorneal Type 12
Dermatitis Exfoliativa Neonatorum 12
Generalized Exfoliative Disease 58
Scalded Skin Syndrome 12
Ritter Disease 12
Ssss 58

Characteristics:

Orphanet epidemiological data:

58
staphylococcal scalded skin syndrome
Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:9063
ICD9CM 34 695.81
MeSH 44 D013206
NCIt 50 C85077
SNOMED-CT 67 87758007
ICD10 32 L00
MESH via Orphanet 45 D013206
ICD10 via Orphanet 33 L00
UMLS via Orphanet 72 C0038165
Orphanet 58 ORPHA36236
UMLS 71 C0038165 C0678185
Sources

Summaries for Ritter's Disease

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Disease Ontology : 12 A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has symptoms redness of skin, has symptom fluid-filled blister formation, has symptom fever and has symptom irritability.

MalaCards based summary : Ritter's Disease, also known as staphylococcal scalded skin syndrome, is related to bullous impetigo and scarlet fever, and has symptoms including fever, irritability and redness of skin. An important gene associated with Ritter's Disease is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, breast and bone marrow, and related phenotypes are immune system and digestive/alimentary

Wikipedia : 74 Staphylococcal scalded skin syndrome (SSSS) is a dermatological condition caused by Staphylococcus... more...

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Related Diseases for Ritter's Disease

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Diseases related to Ritter's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 bullous impetigo 31.1 EDNRB EDNRA DSG3 DSG1
2 scarlet fever 30.9 TST EDNRB EDNRA
3 pyomyositis 30.6 TST EDNRB
4 pemphigus foliaceus 30.5 DSG3 DSG2 DSG1
5 pyoderma 30.3 EDNRB DSG3 DSG1
6 keratosis 29.8 DSP DSG4 DSG2 DSG1
7 skin disease 29.8 DSP DSG4 DSG3 DSG2 DSG1 DSC3
8 impetigo 29.2 TST EDNRB EDNRA DSG4 DSG3 DSG2
9 pemphigus 28.9 DSP DSG4 DSG3 DSG2 DSG1 DSC3
10 bullous skin disease 28.1 DSP DSG4 DSG3 DSG2 DSG1 DSC3
11 ichthyosis bullosa of siemens 11.1
12 recessive dystrophic epidermolysis bullosa-generalized other 11.1
13 exanthem 10.5
14 staphylococcal scarlet fever 10.4
15 erythema multiforme 10.4
16 toxic shock syndrome 10.4
17 chickenpox 10.4
18 dermatitis 10.3
19 exfoliative dermatitis 10.3
20 stevens-johnson syndrome/toxic epidermal necrolysis 10.3
21 pulmonary arterial hypertension associated with connective tissue disease 10.3 EDNRB EDNRA
22 herpetiform pemphigus 10.3 DSG3 DSG1
23 tinea imbricata 10.3 DSG3 DSG1
24 radiation proctitis 10.3 EDNRB EDNRA
25 severe cutaneous adverse reaction 10.3
26 conjunctivitis 10.3
27 erythema multiforme major 10.3
28 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.3
29 acquired color blindness 10.3 EDNRB EDNRA
30 pemphigus vegetans 10.3 DSG1 DSC3
31 perinephritis 10.3 EDNRB EDNRA
32 transient refractive change 10.3 EDNRB EDNRA
33 pemphigoid gestationis 10.2 DSG3 DSG1
34 raynaud disease 10.2 EDNRB EDNRA
35 bacterial infectious disease 10.2
36 cellulitis 10.2
37 mastocytosis 10.2
38 waardenburg syndrome, type 4b 10.2 EDNRB EDNRA
39 chronic pulmonary heart disease 10.2 EDNRB EDNRA
40 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige 10.2 DSP DSG1
41 pemphigus erythematosus 10.2 DSP DSG3
42 striate palmoplantar keratoderma 10.1 DSP DSG1
43 diffuse palmoplantar keratoderma 10.1 DSP DSG1
44 staphyloenterotoxemia 10.1 TST SETBP1
45 dermatitis, atopic 10.1
46 exfoliation syndrome 10.1
47 disease by infectious agent 10.1
48 endocarditis 10.1
49 epidermolysis bullosa 10.1
50 acute kidney failure 10.1

Graphical network of the top 20 diseases related to Ritter's Disease:



Diseases related to Ritter's Disease
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Symptoms & Phenotypes for Ritter's Disease

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Symptoms:

12
  • • fever
  • • irritability
  • • redness of skin
  • • fluid-filled blister formation

MGI Mouse Phenotypes related to Ritter's Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.85 CDH17 DSC1 DSG2 DSG3 DSG4 DSP
2 digestive/alimentary MP:0005381 9.73 CDH17 DSG2 DSG3 DSP EDNRA EDNRB
3 integument MP:0010771 9.61 DSC1 DSC3 DSG1 DSG2 DSG3 DSG4
4 vision/eye MP:0005391 9.32 DSC1 DSC2 DSC3 DSG1 DSG2 DSG3
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Drugs & Therapeutics for Ritter's Disease

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Search Clinical Trials , NIH Clinical Center for Ritter's Disease

Cochrane evidence based reviews: staphylococcal scalded skin syndrome

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Genetic Tests for Ritter's Disease

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Anatomical Context for Ritter's Disease

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MalaCards organs/tissues related to Ritter's Disease:

40
Skin, Breast, Bone Marrow, Kidney, T Cells, Neutrophil
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Publications for Ritter's Disease

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Articles related to Ritter's Disease:

(show top 50) (show all 501)
# Title Authors PMID Year
1
[Desmoglein, the target molecule in autoimmunity and infection]. 54 61
17075192 2006
2
Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins. 54 61
15815014 2005
3
Understanding the mechanism of action of the exfoliative toxins of Staphylococcus aureus. 61 54
14625102 2003
4
Genetic analysis of exfoliative toxin A-producing Staphylococcus aureus isolated from mastitic cow's milk. 61 54
11118740 2001
5
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. 54 61
11062541 2000
6
Mutational analysis of the superantigen staphylococcal exfoliative toxin A (ETA). 61 54
10657676 2000
7
An exfoliative toxin A-converting phage isolated from Staphylococcus aureus strain ZM. 61 54
10789506 2000
8
Staphylococcal scalded skin syndrome: exfoliative toxin A (ETA) induces serine protease activity when combined with A431 cells. 54 61
10447140 1999
9
The structure of the superantigen exfoliative toxin A suggests a novel regulation as a serine protease. 61 54
9048539 1997
10
Action of staphylococcal exfoliative toxins on epidermal cell cultures and organotypic skin. 61 54
1703553 1990
11
Staphylococcal scalded-skin syndrome in preterm infants: A case report. 61
32656763 2021
12
Complete Genome Sequence of Exfoliative Toxin-Producing Staphylococcus aureus Strain MSSA_SSSS_01, Obtained from a Case of Staphylococcal Scalded-Skin Syndrome. 61
33574109 2021
13
Antimicrobial Resistance and Molecular Analysis of Staphylococcus aureus in Staphylococcal Scalded Skin Syndrome among Children in Korea. 61
33463096 2021
14
Staphylococcal scalded skin syndrome: An epidemiological and clinical review of 84 cases. 61
33283348 2020
15
Comparison of adult vs. paediatric inpatients with staphylococcal scalded skin syndrome: a retrospective database analysis. 61
33217773 2020
16
Kawasaki disease mimickers. 61
33249696 2020
17
Synergistic antimicrobial activity of melittin with clindamycin on the expression of encoding exfoliative toxin in Staphylococcus aureus. 61
32450143 2020
18
Vancomycin for severe staphylococcal scalded skin syndrome. 61
32596982 2020
19
The Role of Gram Staining in Staphylococcal Scalded Skin Syndrome. 61
32399357 2020
20
The spectrum of staphylococcal scalded skin syndrome: a case series in children. 61
31587342 2020
21
Pediatric dermatology emergencies. 61
32352437 2020
22
Clindamycin induced toxic epidermal necrolysis versus Staphylococcal scalded skin syndrome: a case report. 61
32395254 2020
23
[Staphylococcal scalded skin syndrome in a pediatric patient with atopic dermatitis]. 61
31984705 2020
24
Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells. 61
31740530 2020
25
Dermatoscopy in life-threatening and severe acute rashes. 61
32197741 2020
26
Perinatal chikungunya induced scalded skin syndrome. 61
33088712 2020
27
Neonatal staphylococcal scalded skin syndrome in a breastfed neonate. 61
31420893 2020
28
Increasing Numbers of Staphylococcal Scalded Skin Syndrome Cases Caused by ST121 in Houston, Texas. 61
31725120 2020
29
Antibiotic sensitivity and clinical outcomes in staphylococcal scalded skin syndrome. 61
31626359 2020
30
Presentation and Management of Staphylococcal Scalded Skin Syndrome in a Child After a Burn Injury: A Case Report. 61
31679026 2020
31
A Desquamating Skin Rash in a Pediatric Patient. 61
31061964 2019
32
Staphylococcal Scalded Skin Syndrome: A Pediatric Dermatological Emergency. 61
31033660 2019
33
Comparative Study of Frozen and Paraffin-Embedded Sections: Evaluation of Inflammatory Dermatoses. 61
30772956 2019
34
Reliability and accuracy of smartphones for paediatric infectious disease consultations for children with rash in the paediatric emergency department. 61
30704422 2019
35
Neonatal Skin Emergencies. 61
30653641 2019
36
Emergence of staphylococcal scalded skin syndrome associated with a new toxinogenic, methicillin-susceptible Staphylococcus aureus clone. 61
30418106 2019
37
Diffuse cutaneous mastocytosis: Case report and literature review. 61
30187958 2018
38
Epidemiology of staphylococcal scalded skin syndrome in US adults. 61
29902545 2018
39
Variation in Diagnostic Test Use and Associated Outcomes in Staphylococcal Scalded Skin Syndrome at Children's Hospitals. 61
30139766 2018
40
Staphylococcal-scalded skin syndrome: evaluation, diagnosis, and management. 61
29508362 2018
41
Rational design of methicillin resistance staphylococcus aureus inhibitors through 3D-QSAR, molecular docking and molecular dynamics simulations. 61
29475176 2018
42
Acrodermatitis acidaemica. 61
29336047 2018
43
Epidemiology of staphylococcal scalded skin syndrome in U.S. children. 61
29077993 2018
44
An outbreak of skin infections in neonates due to a Staphylococcus aureus strain producing the exfoliative toxin A. 61
29110142 2018
45
Epidemiology of staphylococcal scalded skin syndrome in the United States: A cross-sectional study, 2010-2014. 61
29332709 2018
46
Staphylococcal scalded skin syndrome: An uncommon symptomatology revealing an immune deficiency. 61
29248323 2018
47
Staphylococcal scalded skin syndrome in a 4-year-old child: a case report. 61
29378637 2018
48
A Unique Pattern of Staphylococcal Scalded Skin Syndrome-Like Erosions in Patients with Atopic Dermatitis: Dermatitis flammeus. 61
30413224 2018
49
Adult Staphylococcal Scalded Skin Syndrome Successfully Treated with Multimodal Therapy Including Intravenous Immunoglobulin. 61
28815266 2018
50
Staphylococcal Scalded Skin Syndrome Caused by a Rare Variant of Exfoliative-toxin-A+ S. aureus in an Adult Immunocompromised Woman. 61
28853493 2018
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Variations for Ritter's Disease

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Expression for Ritter's Disease

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Search GEO for disease gene expression data for Ritter's Disease.
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Pathways for Ritter's Disease

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Pathways related to Ritter's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 12.97 DSP DSG4 DSG3 DSG2 DSG1 DSC3
2
Keratinization 65
Show member pathways
 11.68 DSP DSG4 DSG3 DSG2 DSG1 DSC3
3
Arrhythmogenic right ventricular cardiomyopathy 36 1
11.62 DSP DSG2 DSC2
4
Apoptotic cleavage of cellular proteins 65
Show member pathways
 11.32 DSP DSG3 DSG2 DSG1
5
Endothelin Pathways 1
10.9 EDNRB EDNRA
6
Prostaglandin Synthesis and Regulation 1
10.8 EDNRB EDNRA
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GO Terms for Ritter's Disease

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Cellular components related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.1 SCIN EDNRB EDNRA DSP DSG4 DSG3
2 cell junction GO:0030054 9.96 SCIN DSP DSG4 DSG3 DSG2 DSG1
3 cell-cell junction GO:0005911 9.76 DSP DSG4 DSG3 DSG2 DSG1 DSC3
4 ficolin-1-rich granule membrane GO:0101003 9.58 DSP DSG1 DSC1
5 desmosome GO:0030057 9.56 DSP DSG4 DSG3 DSG2 DSG1 DSC3
6 intercalated disc GO:0014704 9.54 DSP DSG2 DSC2
7 cornified envelope GO:0001533 9.23 DSP DSG4 DSG3 DSG2 DSG1 DSC3

Biological processes related to Ritter's Disease according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.92 DSG4 DSG3 DSG2 DSG1 DSC3 DSC2
2 keratinization GO:0031424 9.86 DSP DSG4 DSG3 DSG2 DSG1 DSC3
3 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.76 DSG4 DSG3 DSG2 DSG1 DSC3 DSC2
4 regulation of heart rate by cardiac conduction GO:0086091 9.61 DSP DSG2 DSC2
5 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.58 DSP DSG2 DSC2
6 cornification GO:0070268 9.56 DSP DSG4 DSG3 DSG2 DSG1 DSC3
7 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.54 DSP DSG2 DSC2
8 maternal process involved in female pregnancy GO:0060135 9.52 DSG2 DSG1
9 vasoconstriction GO:0042310 9.51 EDNRB EDNRA
10 enteric nervous system development GO:0048484 9.49 EDNRB EDNRA
11 endothelin receptor signaling pathway GO:0086100 9.48 EDNRB EDNRA
12 desmosome organization GO:0002934 9.46 DSP DSG2
13 cell-cell adhesion GO:0098609 9.28 DSP DSG4 DSG3 DSG2 DSG1 DSC3

Molecular functions related to Ritter's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.97 SCIN DSG4 DSG3 DSG2 DSG1 DSC3
2 calcium ion binding GO:0005509 9.28 SCIN DSG4 DSG3 DSG2 DSG1 DSC3
3 gamma-catenin binding GO:0045295 9.26 DSG1 DSC3
4 endothelin receptor activity GO:0004962 9.16 EDNRB EDNRA
5 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.13 DSP DSG2 DSC2
Sources

Sources for Ritter's Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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