Rocky Mountain Spotted Fever (RMSF)

Categories: Infectious diseases, Muscle diseases, Rare diseases
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Aliases & Classifications for Rocky Mountain Spotted Fever

MalaCards integrated aliases for Rocky Mountain Spotted Fever:

Name: Rocky Mountain Spotted Fever 11 19 58 75 2 43 14 71
Exanthematic Typhus of Sao Paulo 11
Brazillian Spotted 11
Sao Paulo Typhus 11
Fiebre Maculosa 11
Fiebre Manchada 11
So Paulo Fever 11
Typhus, Tick 71
Tick Typhus 11
Tobia Fever 11
Choix 11
Rmsf 19


Age Of Onset:

All ages 58


Orphanet: 58  
Rare infectious diseases

External Ids:

Disease Ontology 11 DOID:0050052
MeSH 43 D012373
MESH via Orphanet 44 D012373
ICD10 via Orphanet 32 A77.0
UMLS via Orphanet 72 C0035793
Orphanet 58 ORPHA83311
UMLS 71 C0035793 C0242137

Summaries for Rocky Mountain Spotted Fever

Orphanet: 58 A rare, acquired, life-threatening, infectious disease due to the tick-borne bacteria Rickettsia rickettsii characterized by an acute onset of fever, malaise, and severe headache, variably accompanied by myalgia, anorexia, nausea, vomiting, abdominal pain, and photophobia, associating (2-5 days after fever onset) a typically erythematous, blanching or non-blanching, maculopapluar rash with petechiae, starting on the wrists and ankles and progressing centrifugally to the palms and soles and centripetally to the arms, legs and trunk. Additonal variable features may include conjunctivitis, mucosal ulcers, post-inflammatory hyperpigmentation, jaundice, pneumonia, hepatomegaly, renal failure, meningismus, amnesia, optic disc edema, and ocular arterial occlusion.

MalaCards based summary: Rocky Mountain Spotted Fever, also known as exanthematic typhus of sao paulo, is related to queensland tick typhus and israeli tick typhus, and has symptoms including fever, abdominal pain and headache. An important gene associated with Rocky Mountain Spotted Fever is SLC17A5 (Solute Carrier Family 17 Member 5). The drugs Azithromycin and Doxycycline have been mentioned in the context of this disorder. Affiliated tissues include endothelial, salivary gland and skin.

GARD: 19 Rocky mountain spotted fever refers to an infection caused by the bacterium Rickettsia rickettsia. This particular bacterium is carried by certain species of ticks and spread to humans through the bites of infected ticks. Signs and symptoms of the condition generally develop approximately 2 to 14 days following the tick bite and may include fever, rash, headache, muscle pain, chills, and/or confusion. Some affected people may also experience diarrhea, nausea, vomiting, light sensitivity, hallucinations, and/or excessive thirst. Most cases occur in the spring and summer and are found in children. Risk factors for developing the condition include recent hiking or exposure to ticks in an area where the disease is known to occur.

Disease Ontology: 11 A spotted fever that has material basis in Rickettsia rickettsii, which is transmitted by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has symptom fever, has symptom headache, has symptom abdominal pain, and has symptom maculopapular rash progressing into papular or petechial rash.

CDC: 2 Rocky Mountain spotted fever (RMSF) is a bacterial disease spread through the bite of an infected tick. Most people who get sick with RMSF will have a fever, headache, and rash. RMSF can be deadly if not treated early with the right antibiotic.

Wikipedia: 75 Rocky Mountain spotted fever (RMSF) is a bacterial disease spread by ticks. It typically begins with a... more...

Related Diseases for Rocky Mountain Spotted Fever

Diseases related to Rocky Mountain Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 queensland tick typhus 32.6 SPTBN2 SLC36A2 PLEKHG4 CS AFF2
2 israeli tick typhus 32.3 SPTBN2 PPP1R14A PLEKHG4 CS
3 exanthem 31.4 GPT F3 CRP CD4
4 disseminated intravascular coagulation 31.1 GPT F3 CRP
5 kawasaki disease 30.8 HSPD1 GPT CRP
6 ehrlichiosis 30.8 HSPD1 GPT CS CD4
7 spotted fever 30.7 SPTBN2 SLC17A5 PPP1R14A PLEKHG4 HTRA1 HSPD1
8 indian tick typhus 30.5 PPP1R14A PLEKHG4 CS AFF2
9 cauda equina syndrome 30.5 F3 CRP
10 glanders 30.5 HSPD1 CD4
11 juvenile rheumatoid arthritis 30.4 HSPD1 CRP CD4
12 neuroretinitis 30.4 CRP CD4
13 bronchopneumonia 30.4 GPT CRP CD4
14 splenic infarction 30.4 GPT F3 CRP
15 cardiac tamponade 30.4 GPT F3 CRP
16 cerebritis 30.4 CRP CD4
17 tick infestation 30.4 HSPD1 CS CD4
18 boutonneuse fever 30.3 SPTBN2 PPP1R14A PLEKHG4 HTRA1 HSPD1 CS
19 cervical adenitis 30.3 HSPD1 CRP CD4
20 acute disseminated encephalomyelitis 30.2 HSPD1 CRP CD4
21 factor xi deficiency 30.2 GPT F3 CD4
22 babesiosis 30.2 HSPD1 GPT CRP CD4
23 papilledema 30.2 F3 CRP CD4
24 bacterial sepsis 30.2 F3 CRP CD4
25 chickenpox 30.2 GPT CRP CD4
26 bacterial pneumonia 30.2 GPT CRP CD4
27 respiratory failure 30.1 GPT F3 CRP CD4
28 alcohol use disorder 30.0 SLC17A5 GPT CRP CD4
29 african tick-bite fever 30.0 SPTBN2 PPP1R14A PLEKHG4 CS AFF2
30 urinary tract infection 29.9 GPT F3 CRP CD4
31 hemorrhagic disease 29.9 GPT F3 CRP CD4
32 hemophagocytic lymphohistiocytosis 29.9 GPT F3 CRP CD4
33 scrub typhus 29.8 SLC17A5 GPT F3 CRP
34 hepatitis a 29.8 GPT F3 CD4
35 endemic typhus 29.7 SPTBN2 SLC36A2 PPP1R14A PLEKHG4 HTRA1 HSPD1
36 epidemic typhus 29.4 SPTBN2 SLC36A2 PPP1R14A PLEKHG4 HTRA1 HSPD1
37 colorado tick fever 11.5
38 spotted fever rickettsiosis 11.5
39 selective intrauterine growth restriction 11.5
40 flinders island spotted fever 11.3
41 thrombocytopenia 10.7
42 vasculitis 10.7
43 rickettsial disease 10.7
44 lyme disease 10.6
45 myocarditis 10.6
46 tularemia 10.6
47 acute kidney failure 10.6
48 encephalitis 10.6
49 pulmonary edema 10.6
50 meningoencephalitis 10.5

Graphical network of the top 20 diseases related to Rocky Mountain Spotted Fever:

Diseases related to Rocky Mountain Spotted Fever

Symptoms & Phenotypes for Rocky Mountain Spotted Fever


  • fever
  • abdominal pain
  • headache
  • maculopapular rash progressing into papular

Drugs & Therapeutics for Rocky Mountain Spotted Fever

Drugs for Rocky Mountain Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Azithromycin Approved Phase 3 83905-01-5 447043
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
3 Anti-Bacterial Agents Phase 3
4 Anti-Infective Agents Phase 3
5 Antiprotozoal Agents Phase 3
6 Antiparasitic Agents Phase 3
7 Antimalarials Phase 3

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Efficacy of Azithromycin Plus Doxycycline Compared to Doxycycline Plus Placebo in Patients With Rocky Mountain Spotted Fever in Hospital General de Mexicali of ISESALUD and Hospital General No. 30 Instituto Mexicano Del Seguro Social Recruiting NCT05398055 Phase 3 Azithromycin + Doxycycline;Placebo + Doxycycline

Search NIH Clinical Center for Rocky Mountain Spotted Fever

Cochrane evidence based reviews: rocky mountain spotted fever

Genetic Tests for Rocky Mountain Spotted Fever

Anatomical Context for Rocky Mountain Spotted Fever

Organs/tissues related to Rocky Mountain Spotted Fever:

MalaCards : Endothelial, Salivary Gland, Skin, Lymph Node, Breast, Bone Marrow, Skeletal Muscle

Publications for Rocky Mountain Spotted Fever

Articles related to Rocky Mountain Spotted Fever:

(show top 50) (show all 2044)
# Title Authors PMID Year
Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes. 62
36342274 2023
Benchmarked molecular docking integrated molecular dynamics stability analysis for prediction of SARS-CoV-2 papain-like protease inhibition by olive secoiridoids. 62
36338939 2023
Computational analysis of natural product B-Raf inhibitors. 62
36208592 2023
Interactive deciphering electron-shuttling characteristics of Coffea arabica leaves and potential bioenergy-steered anti-SARS-CoV-2 RdRp inhibitor via microbial fuel cells. 62
36405420 2023
Rational design of an anti-cancer peptide inhibiting CD147 / Cyp A interaction. 62
36128074 2023
Point mutation consideration in CcO protein of the electron transfer chain by MD simulation. 62
36037732 2022
Fimbristylis aestivalis Vahl: a potential source of cyclooxygenase-2 (COX-2) inhibitors. 62
36056995 2022
QSAR, homology modeling, and docking simulation on SARS-CoV-2 and pseudomonas aeruginosa inhibitors, ADMET, and molecular dynamic simulations to find a possible oral lead candidate. 62
35730025 2022
Integrated structure-guided computational design of novel substituted quinolizin-4-ones as Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. 62
36401950 2022
Substitution of PINK1 Gly411 modulates substrate receptivity and turnover. 62
36469690 2022
Detection of Rickettsia montanensis in Dermacentor variabilis in Northern Wisconsin. 62
36322883 2022
Knowledge, attitudes, and practices of Illinois medical professionals related to ticks and tick-borne disease. 62
36277108 2022
Emerging Spotted Fever Rickettsioses in the United States. 62
36336422 2022
Dermatological manifestations of tick-borne viral infections found in the United States. 62
36443864 2022
Immune Monitoring of Paediatric Patients Infected with Rickettsia rickettsii, Ehrlichia canis and Coinfected. 62
36422602 2022
Molecular Dynamics Study on Selected Bioactive Phytochemicals as Potential Inhibitors of HIV-1 Subtype C Protease. 62
36422295 2022
In silico design of a TLR4-mediating multiepitope chimeric vaccine against amyotrophic lateral sclerosis via advanced immunoinformatics. 62
35707959 2022
Structure and dynamic simulation-based interactions of benzenoids, pyrroles and organooxygen compounds for effective targeting of GPX4 in ischemic stroke. 62
36326469 2022
Single substitution in α-helix of active center enhanced thermostability of Aspergillus awamori exo-inulinase. 62
36473387 2022
An immunoinformatic approach employing molecular docking and molecular dynamics simulation for evaluation of l-asparaginase produced by Bacillus velezensis. 62
36377397 2022
Molecular modelling of SdiA protein by selected flavonoid and terpenes compounds to attenuate virulence in Klebsiella pneumoniae. 62
36416609 2022
The search for new efficient inhibitors of SARS-COV-2 through the De novo drug design developed by artificial intelligence. 62
36420665 2022
Synthesis, biological assessment, and computational investigations of nifedipine and monastrol analogues as anti-leishmanial major and anti-microbial agents. 62
36417095 2022
Oncoinformatic screening of the gene clusters involved in the HER2-positive breast cancer formation along with the in silico pharmacodynamic profiling of selective long-chain omega-3 fatty acids as the metastatic antagonists. 62
36445532 2022
Volatile compounds of Bacillus pseudomycoides induce growth and drought tolerance in wheat (Triticum aestivum L.). 62
36352019 2022
Current insights and molecular docking studies of the drugs under clinical trial as rdrp inhibitors in COVID-19 treatment. 62
36345244 2022
Pharmacophore modelling, docking and molecular dynamic simulation studies in the discovery of potential human renin inhibitors. 62
35932508 2022
A designed peptide-based vaccine to combat Brucella melitensis, B. suis and B. abortus: Harnessing an epitope mapping and immunoinformatics approach. 62
36115112 2022
Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE scoring, dynamic studies, and pharmacokinetic prediction. 62
36318405 2022
Molecular modeling, docking and dynamics studies of fenugreek (Trigonella foenum-graecum) α-amylase. 62
36369783 2022
Potential of paracetamol for reproductive disruption: molecular interaction, dynamics, and MM-PBSA based in-silico assessment. 62
36253940 2022
A computational study on strontium ion modified hydroxyapatite-fibronectin interactions. 62
36373734 2022
Analyzing PKC Gamma (+ 19,506 A/G) polymorphism as a promising genetic marker for HCV-induced hepatocellular carcinoma. 62
36451234 2022
Molecular Dynamics Simulations to Decipher the Role of Phosphorylation of SARS-CoV-2 Nonstructural Proteins (nsps) in Viral Replication. 62
36366534 2022
Deep-learning based repurposing of FDA-approved drugs against Candida albicans dihydrofolate reductase and molecular dynamics study. 62
33879017 2022
In Silico Identification of Promising New Pyrazole Derivative-Based Small Molecules for Modulating CRMP2, C-RAF, CYP17, VEGFR, C-KIT, and HDAC-Application towards Cancer Therapeutics. 62
36354673 2022
Phylogenic analysis of coronavirus genome and molecular studies on potential anti-COVID-19 agents from selected FDA-approved drugs. 62
33749538 2022
Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: an in silico study. 62
33970805 2022
MurC ligase of multi-drug resistant Salmonella Typhi can be inhibited by novel Curcumin derivative: Evidence from molecular docking and dynamics simulations. 62
35985453 2022
The interaction analysis between human serum albumin with chlorpyrifos and its derivatives through sub-atomic docking and molecular dynamics simulation techniques. 62
36105863 2022
Identification and molecular modeling of novel endogenous activator proteins of Sirt-1: an in silico study. 62
36229233 2022
An understanding of coronavirus and exploring the molecular dynamics simulations to find promising candidates against the Mpro of nCoV to combat the COVID-19: A systematic review. 62
36288640 2022
In silico study of inhibitory capacity of sacubitril/valsartan toward neprilysin and angiotensin receptor. 62
36321085 2022
Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Rosmarinus officinalis against Alzheimer's Disease. 62
36364071 2022
Modification and application of highly active alkaline pectin lyase. 62
36210372 2022
Virtual screening and molecular dynamics simulation study of abyssomicins as potential inhibitors of COVID-19 virus main protease and spike protein. 62
36300522 2022
Characterization of Synovial Fluid Components: Albumin-Chondroitin Sulfate Interactions Seen through Molecular Dynamics. 62
36234275 2022
Screening, Docking, and Molecular Dynamics Study of Natural Compounds as an Anti-HER2 for the Management of Breast Cancer. 62
36362883 2022
In silico, in vitro VEGFR-2 inhibition, and anticancer activity of a 3-(hydrazonomethyl)naphthalene-2-ol derivative. 62
36184591 2022
Molecular modeling, molecular dynamics simulation, and essential dynamics analysis of grancalcin: An upregulated biomarker in experimental autoimmune encephalomyelitis mice. 62
36340004 2022

Variations for Rocky Mountain Spotted Fever

Expression for Rocky Mountain Spotted Fever

Search GEO for disease gene expression data for Rocky Mountain Spotted Fever.

Pathways for Rocky Mountain Spotted Fever

GO Terms for Rocky Mountain Spotted Fever

Sources for Rocky Mountain Spotted Fever

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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