RMSF
MCID: RCK002
MIFTS: 34

Rocky Mountain Spotted Fever (RMSF)

Categories: Infectious diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Rocky Mountain Spotted Fever

MalaCards integrated aliases for Rocky Mountain Spotted Fever:

Name: Rocky Mountain Spotted Fever 12 73 20 58 3 15 70
Exanthematic Typhus of Sao Paulo 12
Brazillian Spotted 12
Sao Paulo Typhus 12
Fiebre Maculosa 12
Fiebre Manchada 12
So Paulo Fever 12
Typhus, Tick 70
Tick Typhus 12
Tobia Fever 12
Choix 12
Rmsf 20

Characteristics:

Orphanet epidemiological data:

58
rocky mountain spotted fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050052
MESH via Orphanet 45 D012373
ICD10 via Orphanet 33 A77.0
UMLS via Orphanet 71 C0035793
Orphanet 58 ORPHA83311
UMLS 70 C0035793 C0242137

Summaries for Rocky Mountain Spotted Fever

GARD : 20 Rocky Mountain spotted fever refers to an infection caused by the bacterium Rickettsia rickettsia. This particular bacterium is carried by certain species of ticks and spread to humans through the bites of infected ticks. Signs and symptoms of the condition generally develop approximately 2 to 14 days following the tick bite and may include fever, rash, headache, muscle pain, chills, and/or confusion. Some affected people may also experience diarrhea, nausea, vomiting, light sensitivity, hallucinations, and/or excessive thirst. Most cases occur in the spring and summer and are found in children. Risk factors for developing the condition include recent hiking or exposure to ticks in an area where the disease is known to occur. Rocky Mountain spotted fever is typically treated with antibiotics (such as doxycycline or tetracycline).

MalaCards based summary : Rocky Mountain Spotted Fever, also known as exanthematic typhus of sao paulo, is related to queensland tick typhus and israeli tick typhus, and has symptoms including fever, abdominal pain and headache. An important gene associated with Rocky Mountain Spotted Fever is SLC17A5 (Solute Carrier Family 17 Member 5). Affiliated tissues include endothelial, skin and brain.

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia rickettsii, which is transmitted by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has symptom fever, has symptom headache, has symptom abdominal pain, and has symptom maculopapular rash progressing into papular or petechial rash.

CDC : 3 Rocky Mountain spotted fever (RMSF) is a bacterial disease spread through the bite of an infected tick. Most people who get sick with RMSF will have a fever, headache, and rash. RMSF can be deadly if not treated early with the right antibiotic.

Wikipedia : 73 Rocky Mountain spotted fever (RMSF) is a bacterial disease spread by ticks. It typically begins with a... more...

Related Diseases for Rocky Mountain Spotted Fever

Diseases related to Rocky Mountain Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 queensland tick typhus 33.1 PLEKHG4 CS
2 israeli tick typhus 32.4 SPTBN2 PPP1R14A PLEKHG4
3 flinders island spotted fever 32.4 PLEKHG4 AFF2
4 spotted fever 32.1 SPTBN2 PPP1R14A PLEKHG4 HTRA1 CS AFF2
5 indian tick typhus 30.7 PPP1R14A PLEKHG4 AFF2
6 bronchopneumonia 30.4 GPT F3
7 splenic infarction 30.4 GPT F3
8 boutonneuse fever 30.4 SPTBN2 PPP1R14A PLEKHG4 PATL2 CS AFF2
9 endemic typhus 30.0 SPTBN2 PPP1R14A PLEKHG4 PCDHGB7 HTRA1 HSPD1
10 scrub typhus 29.9 SLC17A5 GPT F3
11 epidemic typhus 29.2 SPTBN2 SLC36A2 PPP1R14A PLEKHG4 PATL2 HTRA1
12 colorado tick fever 11.5
13 exanthem 11.2
14 thrombocytopenia 10.8
15 vasculitis 10.7
16 ehrlichiosis 10.7
17 rickettsial disease 10.7
18 disseminated intravascular coagulation 10.6
19 lyme disease 10.6
20 myocarditis 10.6
21 encephalitis 10.6
22 tularemia 10.6
23 acute kidney failure 10.6
24 pulmonary edema 10.6
25 kawasaki disease 10.5
26 meningoencephalitis 10.5
27 acute kidney tubular necrosis 10.5
28 measles 10.5
29 neutropenia 10.5
30 uveitis 10.5
31 toxic shock syndrome 10.5
32 purpura 10.5
33 tick infestation 10.5
34 kidney disease 10.5
35 ocular motor apraxia 10.4
36 interstitial nephritis 10.4
37 q fever 10.4
38 respiratory failure 10.4
39 glomerulonephritis 10.4
40 plague 10.4
41 appendicitis 10.4
42 neuropathy 10.4
43 iridocyclitis 10.4
44 meningitis 10.4
45 babesiosis 10.4
46 headache 10.4
47 spotted fever rickettsiosis 10.4
48 spinocerebellar ataxia 18 10.3 SPTBN2 PLEKHG4
49 cerebellar ataxia type 9 10.3 SPTBN2 PLEKHG4
50 tungiasis 10.3 PPP1R14A AFF2

Graphical network of the top 20 diseases related to Rocky Mountain Spotted Fever:



Diseases related to Rocky Mountain Spotted Fever

Symptoms & Phenotypes for Rocky Mountain Spotted Fever

Symptoms:

12
  • fever
  • abdominal pain
  • headache
  • maculopapular rash progressing into papular

Drugs & Therapeutics for Rocky Mountain Spotted Fever

Search Clinical Trials , NIH Clinical Center for Rocky Mountain Spotted Fever

Genetic Tests for Rocky Mountain Spotted Fever

Anatomical Context for Rocky Mountain Spotted Fever

MalaCards organs/tissues related to Rocky Mountain Spotted Fever:

40
Endothelial, Skin, Brain, Bone Marrow, Lymph Node, Kidney, Salivary Gland

Publications for Rocky Mountain Spotted Fever

Articles related to Rocky Mountain Spotted Fever:

(show top 50) (show all 1136)
# Title Authors PMID Year
1
Isolation of Rickettsia rickettsii in Rocky Mountain Spotted Fever Outbreak, Panama. 61
33755006 2021
2
Assessment of the Pathogenicity of Rickettsia amblyommatis, Rickettsia bellii, and Rickettsia montanensis in a Guinea Pig Model. 61
33600263 2021
3
Detection of Rickettsia amblyommatis and Ehrlichia chaffeensis in Amblyomma americanum Inhabiting Two Urban Parks in Oklahoma. 61
33733878 2021
4
Diversity of rickettsiae in domestic, synanthropic, and sylvatic mammals and their ectoparasites in a spotted fever-epidemic region at the western US-Mexico border. 61
33667026 2021
5
Recent advances in understanding tick and rickettsiae interactions. 61
33713348 2021
6
Likely Geographic Distributional Shifts among Medically Important Tick Species and Tick-Associated Diseases under Climate Change in North America: A Review. 61
33807736 2021
7
Isolate-Dependent Differences in Clinical, Pathological, and Transcriptional Profiles following In Vitro and In Vivo Infections with Rickettsia rickettsii. 61
33495273 2021
8
Dermacentor variabilis is the Predominant Dermacentor spp. (Acari: Ixodidae) Feeding on Dogs and Cats Throughout the United States. 61
33615364 2021
9
Surveillance for Vector-borne Diseases Among Active and Reserve Component Service Members, U.S. Armed Forces, 2016-2020. 61
33636087 2021
10
Significant Growth by Rickettsia Species within Human Macrophage-Like Cells Is a Phenotype Correlated with the Ability to Cause Disease in Mammals. 61
33669499 2021
11
A Space-Time Permutation Scan Statistic for Evaluating County-Level Tickborne Disease Clusters in Indiana, 2009-2016. 61
33156708 2021
12
Knowledge, Attitudes, and Practices Related to Rocky Mountain Spotted Fever in Hermosillo, México. 61
33219641 2021
13
Epidemiology and Clinical Features of Rocky Mountain Spotted Fever from Enhanced Surveillance, Sonora, Mexico: 2015-2018. 61
33146112 2021
14
Behavioral characteristics and endosymbionts of two potential tularemia and Rocky Mountain spotted fever tick vectors. 61
33207056 2020
15
Meningoencephalitis Due to Spotted Fever Rickettsioses, Including Rocky Mountain Spotted Fever. 61
33370041 2020
16
Exploring the Niche of Rickettsia montanensis (Rickettsiales: Rickettsiaceae) Infection of the American Dog Tick (Acari: Ixodidae), Using Multiple Species Distribution Model Approaches. 61
33274379 2020
17
The intracellular bacterium Rickettsia rickettsii exerts an inhibitory effect on the apoptosis of tick cells. 61
33261663 2020
18
The guinea pig model for tick-borne spotted fever rickettsioses: A second look. 61
32993947 2020
19
What's eating you? human flea (Pulex irritans). 61
33465194 2020
20
Surveillance of spotted fever rickettsioses at Army installations in the U.S. Central and Atlantic regions, 2012-2018. 61
32991196 2020
21
New Jersey-Wide Survey of Spotted Fever Group Rickettsia (Proteobacteria: Rickettsiaceae) in Dermacentor variabilis and Amblyomma americanum (Acari: Ixodida: Ixodidae). 61
32588804 2020
22
The Ability of the Invasive Asian Longhorned Tick Haemaphysalis longicornis (Acari: Ixodidae) to Acquire and Transmit Rickettsia rickettsii (Rickettsiales: Rickettsiaceae), the Agent of Rocky Mountain Spotted Fever, Under Laboratory Conditions. 61
32338290 2020
23
Comparative Analysis of Infection by Rickettsia rickettsii Sheila Smith and Taiaçu Strains in a Murine Model. 61
32927666 2020
24
Risk Factors for Scrub Typhus, Murine Typhus, and Spotted Fever Seropositivity in Urban Areas, Rural Plains, and Peri-Forest Hill Villages in South India: A Cross-Sectional Study. 61
32458785 2020
25
Serosurvey of arthropod-borne diseases among shelter dogs in the Cumberland Gap Region of the United States. 61
32605566 2020
26
Meningoencephalitis due to Spotted Fever Rickettsioses, Including Rocky Mountain Spotted Fever. 61
31412360 2020
27
Tickborne Diseases: Diagnosis and Management. 61
32352736 2020
28
Comparative analysis of the midgut microbiota of two natural tick vectors of Rickettsia rickettsii. 61
31904432 2020
29
Selective fragmentation of the trans-Golgi apparatus by Rickettsia rickettsii. 61
32421751 2020
30
Rickettsia spp. Infecting Lone Star Ticks (Amblyomma americanum) (Acari: Ixodidae) in Monmouth County, New Jersey. 61
31912880 2020
31
Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy. 61
32414479 2020
32
Molecular detection of Rickettsia species in ticks collected in the Mexico-USA transboundary region. 61
32249393 2020
33
Ecology and Epidemiology of Tickborne Pathogens, Washington, USA, 2011-2016. 61
32187009 2020
34
COYOTES (CANIS LATRANS) IN ARIZONA, USA, EXHIBIT IMMUNE AND GENETIC EVIDENCE OF RICKETTSIAL INFECTIONS. 61
31658430 2020
35
Community-based prevention of epidemic Rocky Mountain spotted fever among minority populations in Sonora, Mexico, using a One Health approach. 61
31819997 2020
36
Spotted fever group rickettsiae canine serosurveillance near the US-Mexico border in California. 61
31769616 2020
37
Antibody Titers Reactive With Rickettsia rickettsii in Blood Donors and Implications for Surveillance of Spotted Fever Rickettsiosis in the United States. 61
31267128 2020
38
Molecular Detection of Spotted Fever Group Rickettsiae (Rickettsiales: Rickettsiaceae) in Dermacentor variabilis (Acari: Ixodidae) Collected Along the Platte River in South Central Nebraska. 61
31576408 2020
39
Documentation of the Expansion of the Gulf Coast Tick (Amblyomma maculatum) and Rickettsia parkeri: First Report in Illinois. 61
31958375 2020
40
Expanding Recognition of Rickettsia parkeri Rickettsiosis in Southern Arizona, 2016-2017. 61
31638478 2020
41
Gastrointestinal and hepatic symptoms of tickborne diseases. 61
32972180 2020
42
Reported County-Level Distribution of the American Dog Tick (Acari: Ixodidae) in the Contiguous United States. 61
31368492 2020
43
Detection of Bartonella spp. in dogs after infection with Rickettsia rickettsii. 61
31891215 2020
44
Is Rocky Mountain spotted fever the only disease of the spotted fever group rickettsioses found in Mexico? 61
33186342 2020
45
Needlestick-Associated Rocky Mountain Spotted Fever, Brazil. 61
32187008 2020
46
An exploratory analysis of demography and movement patterns of dogs: New insights in the ecology of endemic Rocky Mountain-Spotted Fever in Mexicali, Mexico. 61
32437470 2020
47
Brain Death Secondary to Rocky Mountain Spotted Fever Encephalitis. 61
32426169 2020
48
Seroprevalence of spotted fever group rickettsiae in canines along the United States-Mexico border. 61
31441594 2019
49
Knowledge and prevention of tickborne diseases among Hispanic and non-Hispanic residents of Maryland and Virginia. 61
31478316 2019
50
Susceptibility of Rickettsia rickettsii to Tigecycline in a Cell Culture Assay and Animal Model for Rocky Mountain Spotted Fever. 61
31516114 2019

Variations for Rocky Mountain Spotted Fever

Expression for Rocky Mountain Spotted Fever

Search GEO for disease gene expression data for Rocky Mountain Spotted Fever.

Pathways for Rocky Mountain Spotted Fever

GO Terms for Rocky Mountain Spotted Fever

Sources for Rocky Mountain Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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