MCID: RCK002
MIFTS: 41

Rocky Mountain Spotted Fever

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Rocky Mountain Spotted Fever

MalaCards integrated aliases for Rocky Mountain Spotted Fever:

Name: Rocky Mountain Spotted Fever 12 76 53 59 3 15 73
Rmsf 53 3
Exanthematic Typhus of Sao Paulo 12
Brazillian Spotted 12
Sao Paulo Typhus 12
Fiebre Maculosa 12
Fiebre Manchada 12
So Paulo Fever 12
Typhus, Tick 73
Tick Typhus 12
Tobia Fever 12
Choix 12

Characteristics:

Orphanet epidemiological data:

59
rocky mountain spotted fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050052
Orphanet 59 ORPHA83311
MESH via Orphanet 45 D012373
UMLS via Orphanet 74 C0035793
ICD10 via Orphanet 34 A77.0

Summaries for Rocky Mountain Spotted Fever

NIH Rare Diseases : 53 Rocky Mountain spotted fever refers to an infection caused by the bacterium Rickettsia rickettsia. This particular bacterium is carried by certain species of ticks and spread to humans through the bites of infected ticks. Signs and symptoms of the condition generally develop approximately 2 to 14 days following the tick bite and may include fever, rash, headache, muscle pain, chills, and/or confusion. Some affected people may also experience diarrhea, nausea, vomiting, light sensitivity, hallucinations, and/or excessive thirst. Most cases occur in the spring and summer and are found in children. Risk factors for developing the condition include recent hiking or exposure to ticks in an area where the disease is known to occur. Rocky Mountain spotted fever is typically treated with antibiotics (such as doxycycline or tetracycline).

MalaCards based summary : Rocky Mountain Spotted Fever, also known as rmsf, is related to epidemic typhus and queensland tick typhus, and has symptoms including fever, headache and abdominal pain. An important gene associated with Rocky Mountain Spotted Fever is SLC17A5 (Solute Carrier Family 17 Member 5), and among its related pathways/superpathways are NF-kappa B signaling pathway and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and monocytes.

CDC : 3 Rocky Mountain spotted fever (RMSF) is a bacterial disease spread through the bite of an infected tick. Most people who get sick with RMSF will have a fever, headache, and rash. RMSF can be deadly if not treated early with the right antibiotic.

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia rickettsii, which is transmitted by ticks (Dermacentor variabilis and Dermacentor andersoni). The infection has symptom fever, has symptom headache, has symptom abdominal pain, and has symptom maculopapular rash progressing into papular or petechial rash.

Wikipedia : 76 Rocky Mountain spotted fever (RMSF), also known as blue disease, is the most lethal and most frequently... more...

Related Diseases for Rocky Mountain Spotted Fever

Diseases related to Rocky Mountain Spotted Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 epidemic typhus 29.0 AFF2 CD40LG MRRF
2 queensland tick typhus 12.6
3 siberian tick typhus 12.6
4 colorado tick fever 11.7
5 spotted fever 11.4
6 ehrlichiosis 10.5
7 lyme disease 10.4
8 thrombocytopenia 10.4
9 encephalitis 10.4
10 endemic typhus 10.3
11 tularemia 10.3
12 measles 10.3
13 aging 10.2
14 kawasaki disease 10.2
15 boutonneuse fever 10.2
16 cerebritis 10.2
17 tick infestation 10.2
18 myocarditis 10.2
19 appendicitis 10.2
20 meningitis 10.2
21 endotheliitis 10.2
22 brill-zinsser disease 10.1 AFF2 CD40LG
23 tardive dyskinesia 10.1
24 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
25 adult respiratory distress syndrome 10.1
26 arthritis 10.1
27 glomerulonephritis 10.1
28 hepatitis 10.1
29 human monocytic ehrlichiosis 10.1
30 indian tick typhus 10.1
31 atrial fibrillation 10.1
32 eosinophilic meningitis 10.1
33 meningoencephalitis 10.1
34 thrombotic thrombocytopenic purpura 10.1
35 q fever 10.1
36 rickettsialpox 10.1
37 disseminated intravascular coagulation 10.1
38 tick paralysis 10.1
39 cardiac tamponade 10.1
40 sodoku disease 10.1
41 neurogenic bladder 10.1
42 uveitis 10.1
43 typhoid fever 10.1
44 adult-onset still's disease 10.1
45 thrombocytopenia due to platelet alloimmunization 10.1
46 vascular disease 10.1
47 pericarditis 10.1
48 cholecystitis 10.1
49 sensory peripheral neuropathy 10.1
50 orchitis 10.1

Graphical network of the top 20 diseases related to Rocky Mountain Spotted Fever:



Diseases related to Rocky Mountain Spotted Fever

Symptoms & Phenotypes for Rocky Mountain Spotted Fever

Symptoms:

12
  • fever
  • headache
  • abdominal pain
  • maculopapular rash progressing into papular or petechial rash

Drugs & Therapeutics for Rocky Mountain Spotted Fever

Drugs for Rocky Mountain Spotted Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 300 Antibody Diagnostic Test Kit Unknown status NCT01646411

Search NIH Clinical Center for Rocky Mountain Spotted Fever

Genetic Tests for Rocky Mountain Spotted Fever

Anatomical Context for Rocky Mountain Spotted Fever

MalaCards organs/tissues related to Rocky Mountain Spotted Fever:

41
Testes, Skin, Monocytes, Endothelial, Brain, Liver, Skeletal Muscle

Publications for Rocky Mountain Spotted Fever

Articles related to Rocky Mountain Spotted Fever:

(show top 50) (show all 532)
# Title Authors Year
1
Descriptions of two new cases of Rocky Mountain spotted fever in Panama, and coincident infection with Rickettsia rickettsii in Rhipicephalus sanguineus s.l. in an urban locality of Panama City, Panama. ( 29619916 )
2018
2
Possible Northward Introgression of a Tropical Lineage of Rhipicephalus sanguineus Ticks at a Site of Emerging Rocky Mountain Spotted Fever. ( 29553918 )
2018
3
Rocky Mountain spotted fever: brain imaging findings. ( 29500944 )
2018
4
The Evaluation and Management of Rocky Mountain Spotted Fever in the Emergency Department: a Review of the Literature. ( 29685474 )
2018
5
Medical knowledge related to Rocky Mountain spotted fever in Sonora, Mexico. ( 29617892 )
2018
6
Tick borne illness - Rocky mountain spotted fever. ( 29549965 )
2018
7
Rocky Mountain Spotted Fever and Pregnancy: Four Cases from Sonora, Mexico. ( 28722584 )
2017
8
Fatal Rocky Mountain Spotted Fever along the United States-Mexico Border, 2013-2016. ( 28930006 )
2017
9
Investigating the Adult Ixodid Tick Populations and Their Associated Anaplasma, Ehrlichia, and Rickettsia Bacteria at a Rocky Mountain Spotted Fever Hotspot in Western Tennessee. ( 28598270 )
2017
10
Tick, Rickettsia Rickettsiae (Rocky Mountain Spotted Fever) ( 28613631 )
2017
11
Rocky Mountain Spotted Fever. ( 28055518 )
2017
12
Immune Thrombocytopenia as a Consequence of Rocky Mountain Spotted Fever. ( 29279696 )
2017
13
Child Neurology: Rocky Mountain spotted fever encephalitis. ( 28289173 )
2017
14
Rocky Mountain spotted fever in Mexico: past, present, and future. ( 28365226 )
2017
15
Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States. ( 27172113 )
2016
16
Hierarchical Bayesian Spatio-Temporal Analysis of Climatic and Socio-Economic Determinants of Rocky Mountain Spotted Fever. ( 26942604 )
2016
17
Retrospective Study of Rocky Mountain Spotted Fever in Children. ( 27990680 )
2016
18
Estimation of Rickettsia rickettsii copy number in the blood of patients with Rocky Mountain spotted fever suggests cyclic diurnal trends in bacteraemia. ( 26724989 )
2016
19
Notes from the Field: Community-Based Prevention of Rocky Mountain Spotted Fever - Sonora, Mexico, 2016. ( 27880753 )
2016
20
Rocky Mountain spotted fever in Native Americans. ( 26333334 )
2015
21
Ongoing Cerebral Vasculitis During Treatment of Rocky Mountain Spotted Fever. ( 26294045 )
2015
22
Teaching NeuroImages: Starry-sky appearance in Rocky Mountain spotted fever. ( 26391418 )
2015
23
Risk Factors for Fatal Outcome From Rocky Mountain Spotted Fever in a Highly Endemic Area-Arizona, 2002-2011. ( 25697742 )
2015
24
Medical and Indirect Costs Associated with a Rocky Mountain Spotted Fever Epidemic in Arizona, 2002-2011. ( 26033020 )
2015
25
No Visible Dental Staining in Children Treated with Doxycycline for Suspected Rocky Mountain Spotted Fever. ( 25794784 )
2015
26
Rocky Mountain Spotted Fever Characterization and Comparison to Similar Illnesses in a Highly Endemic Area-Arizona, 2002-2011. ( 25697743 )
2015
27
"Rickettsia amblyommii" induces cross protection against lethal Rocky Mountain spotted fever in a guinea pig model. ( 25072985 )
2014
28
Inadequacy of IgM antibody tests for diagnosis of Rocky Mountain Spotted Fever. ( 25092818 )
2014
29
Clinical Profile and Predictors of Fatal Rocky Mountain Spotted Fever in Children from Sonora, Mexico. ( 25126856 )
2014
30
Murine cutaneous responses to the rocky mountain spotted fever vector, Dermacentor andersoni, feeding. ( 24847317 )
2014
31
Surface protein Adr2 of Rickettsia rickettsii induced protective immunity against Rocky Mountain spotted fever in C3H/HeN mice. ( 24582636 )
2014
32
Clinical presentation, convalescence, and relapse of rocky mountain spotted fever in dogs experimentally infected via tick bite. ( 25542001 )
2014
33
Phylogeography of Rickettsia rickettsii genotypes associated with fatal Rocky Mountain spotted fever. ( 24957541 )
2014
34
Why sulfonamides are contraindicated in Rocky Mountain spotted fever. ( 24612569 )
2014
35
Underdiagnoses of Fatal Rocky Mountain Spotted Fever with Co-Infections: Case Report of Infection with Rickettsia rickettsii and Streptococcus pyogenes. ( 25331804 )
2014
36
Community-based control of the brown dog tick in a region with high rates of Rocky Mountain spotted fever, 2012-2013. ( 25479289 )
2014
37
Atypical Rocky Mountain spotted fever with polyarticular arthritis. ( 24157965 )
2013
38
Rocky Mountain spotted fever in children. ( 23481111 )
2013
39
Rocky Mountain Spotted Fever in a patient treated with anti-TNF-alpha inhibitors. ( 23552004 )
2013
40
S. Burt Wolbach, Rocky Mountain spotted fever, and blood-sucking arthropods: triumph of an early investigative pathologist. ( 23256917 )
2013
41
Self-Reported Treatment Practices by Healthcare Providers Could Lead to Death from Rocky Mountain Spotted Fever. ( 24252781 )
2013
42
Knowledge, attitudes, and practices regarding Rocky Mountain spotted fever among healthcare providers, Tennessee, 2009. ( 23243110 )
2013
43
Modelling spatial concordance between Rocky Mountain spotted fever disease incidence and habitat probability of its vector Dermacentor variabilis (American dog tick). ( 23242684 )
2012
44
A fatal urban case of rocky mountain spotted fever presenting an eschar in San Jose, Costa Rica. ( 22855769 )
2012
45
Fatal Rocky Mountain spotted fever in the United States, 1999-2007. ( 22492159 )
2012
46
Occurrence of pathogenic fungi to Amblyomma cajennense in a rural area of Central Brazil and their activities against vectors of Rocky Mountain spotted fever. ( 22459109 )
2012
47
Rocky Mountain spotted fever. ( 22608123 )
2012
48
Trends in clinical diagnoses of Rocky Mountain spotted fever among American Indians, 2001-2008. ( 22232466 )
2012
49
Association between sepsis and Rocky Mountain spotted fever. ( 23220832 )
2012
50
Experimental infection of the tick Amblyomma cajennense, Cayenne tick, with Rickettsia rickettsii, the agent of Rocky Mountain spotted fever. ( 22007869 )
2012

Variations for Rocky Mountain Spotted Fever

Expression for Rocky Mountain Spotted Fever

Search GEO for disease gene expression data for Rocky Mountain Spotted Fever.

Pathways for Rocky Mountain Spotted Fever

Pathways related to Rocky Mountain Spotted Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.23 CD40LG NFKBIA
2
Show member pathways
11.02 CD40LG NFKBIA
3
Show member pathways
10.76 CD40LG NFKBIA
4 10.1 CD40LG NFKBIA

GO Terms for Rocky Mountain Spotted Fever

Biological processes related to Rocky Mountain Spotted Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 8.62 CD40LG NFKBIA

Sources for Rocky Mountain Spotted Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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