MCID: RTC003
MIFTS: 33

Root Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Root Caries

MalaCards integrated aliases for Root Caries:

Name: Root Caries 12 54 44 15 17 70
Dental Caries of Root Surface 12
Cementum Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14089
ICD9CM 34 521.08
MeSH 44 D017213
SNOMED-CT 67 30512007
ICD10 32 K02.2
UMLS 70 C0162644

Summaries for Root Caries

MalaCards based summary : Root Caries, also known as dental caries of root surface, is related to enamel caries and actinomycosis. An important gene associated with Root Caries is DSPP (Dentin Sialophosphoprotein). The drugs Protective Agents and Fluorides have been mentioned in the context of this disorder. Affiliated tissues include bone, salivary gland and neutrophil.

Related Diseases for Root Caries

Diseases related to Root Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 68)
# Related Disease Score Top Affiliating Genes
1 enamel caries 30.6 STATH AMELX
2 actinomycosis 30.1 STATH ALB
3 dental caries 30.1 STATH LTF DSPP CD79A AMELX ALB
4 gingival recession 10.7
5 periodontitis 10.4
6 hair whorl 10.3
7 glomerular disease 10.3 CD79A ALB
8 epilepsy, familial temporal lobe, 2 10.3 DSPP ALB
9 pleural empyema 10.3 CD79A ALB
10 calciphylaxis 10.2 CD79A ALB
11 arteriolosclerosis 10.2 CD79A ALB
12 acute poststreptococcal glomerulonephritis 10.2 CD79A ALB
13 clostridium difficile colitis 10.2 LTF ALB
14 giardiasis 10.2 CD79A ALB
15 gastric lymphoma 10.2 CD79A ALB
16 angular cheilitis 10.2 STATH ALB
17 focal dermal hypoplasia 10.2 CD79A ALB
18 henoch-schoenlein purpura 10.2 CD79A ALB
19 autosomal recessive hypophosphatemic rickets 10.2 STATH DSPP
20 hypersensitivity reaction type iii disease 10.2 CD79A ALB
21 gingivitis 10.2
22 amebiasis 10.2 CD79A ALB
23 bacteriuria 10.2 CD79A ALB
24 perinatal necrotizing enterocolitis 10.1 LTF ALB
25 proteinuria, chronic benign 10.1 CD79A ALB
26 protein-losing enteropathy 10.1 CD79A ALB
27 dentin caries 10.1
28 lipoid nephrosis 10.1 CD79A ALB
29 pulp degeneration 10.1 DSPP AMELX
30 dental pulp calcification 10.1 DSPP AMELX
31 parotitis 10.1 LTF CD79A ALB
32 keratoconjunctivitis sicca 10.1 LTF CD79A ALB
33 hypercementosis 10.1 DSPP AMELX
34 dental pulp necrosis 10.1 DSPP AMELX
35 acute apical periodontitis 10.1 STATH CST4
36 guillain-barre syndrome 10.1 CD79A ALB
37 dental pulp disease 10.1 DSPP AMELX
38 tooth resorption 10.1 DSPP AMELX
39 blepharitis 10.1 LTF CST4
40 trichodentoosseous syndrome 10.1 DSPP AMELX
41 syphilis 10.1 CD79A ALB
42 dental fluorosis 10.1 DSPP AMELX
43 enamel erosion 10.0 STATH AMELX
44 48,xyyy 10.0
45 meningoencephalitis 10.0 CD79A ALB
46 dentin dysplasia 10.0 DSPP AMELX
47 esophageal varix 9.9 CBX8 ALB
48 tooth erosion 9.9 STATH DSPP AMELX
49 teeth hard tissue disease 9.9 STATH DSPP AMELX
50 type 2 diabetes mellitus 9.9

Graphical network of the top 20 diseases related to Root Caries:



Diseases related to Root Caries

Symptoms & Phenotypes for Root Caries

Drugs & Therapeutics for Root Caries

Drugs for Root Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Protective Agents Phase 1, Phase 2
2 Fluorides Phase 1, Phase 2
3
Dopamine Approved Phase 1 62-31-7, 51-61-6 681
4
Methamphetamine Approved, Illicit Phase 1 537-46-2 10836
5 Neurotransmitter Agents Phase 1
6 Central Nervous System Stimulants Phase 1
7 Dopamine Agents Phase 1
8 Sympathomimetics Phase 1
9 Adrenergic Agents Phase 1
10 Dopamine Uptake Inhibitors Phase 1
11
Povidone-iodine Approved 25655-41-8
12
Povidone Approved 9003-39-8 131751496
13
Iodine Approved, Investigational 7553-56-2 807
14
Petrolatum Approved, Investigational 8009-03-8
15
sodium fluoride Approved 7681-49-4
16
Cadexomer iodine Experimental 94820-09-4
17
Imidacloprid Vet_approved 105827-78-9 86418
18 Anti-Bacterial Agents
19 Photosensitizing Agents
20 Anti-Infective Agents
21 Hormones
22 Calcium, Dietary
23 Carbopol 940
24 Anesthetics
25 Anesthetics, Local
26 Pharmaceutical Solutions
27 Fluorides, Topical
28 Listerine
29
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Non-invasive Therapy With Fluoridated Toothpastes for Root Caries in Independently-living Older Adults Completed NCT02647203 Phase 1, Phase 2 Self-administered fluoridated dentifrices
2 Clinical Evaluation of Nano Hydroxyapatite Reinforced Glass Ionomer Versus Conventional Glass Ionomer in Treatment of Root Caries in Geriatric Patients: A Randomized Controlled Clinical Trial Active, not recruiting NCT04701320 Phase 1 Conventional glass ionomer;Nano hydroxyapatite reinforced glass ionomer
3 Clinical Effect of Photoactivated Disinfection on Primary Root Carious Lesions After Partial Caries Removal Unknown status NCT03186352
4 Randomised Controlled Clinical Trial to Compare Restorative Materials in the Treatment of Root Caries in an Older Irish Population. Unknown status NCT01866059
5 Effectiveness of Using Silver Diammine Fluoride Solution and Combination of Povidone Iodine and Sodium Fluoride Varnish in Preventing Dental Root Caries in Elders: a Randomized, Double-blind, Non-inferiority Trial Unknown status NCT03654820
6 Randomized Double-blind Placebo-controlled Trial of Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers Unknown status NCT03185104 Silver Diamine Fluoride;Distilled Water
7 5-year Clinical Evaluation of Cavity Lining on the Restoration of Root Surface Caries Lesions: A Controlled Randomized Clinical Trial Unknown status NCT03802539
8 Nobio Antimicrobial Particles Effect in a Split Mouth Model Unknown status NCT03501784
9 Silver Diamine Fluoride Treatment of Active Root Caries Lesions in Older Adults: A Case Series Completed NCT04370080
10 The Use of Intraoral Imaging at Clinical Crown Lengthening Procedures Recruiting NCT03064217
11 Clinical Performance of a Micro-hybride Resin Based Composite in the Treatment of Cervical Caries Lesions: 36-month, Split-mouth, Randomized Clinical Trial Active, not recruiting NCT03722758
12 Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults Not yet recruiting NCT04255251 Early Phase 1 Silver Diammine Fluoride;Fluoride Varnishes
13 Excavation of Root Caries With Air-water Powder Stream vs Manual Excavation for Atraumatic Restorative Treatment in Older Patients: a Single-blind Randomized Controlled Trial Not yet recruiting NCT04822246
14 Comparison of the Efficacy of Silver Diamine Fluoride Solution and Sodium Fluoride Varnish for the Prevention and Arrest of Root Caries in a Group of Older Adults Suspended NCT04432415

Search NIH Clinical Center for Root Caries

Cochrane evidence based reviews: root caries

Genetic Tests for Root Caries

Anatomical Context for Root Caries

MalaCards organs/tissues related to Root Caries:

40
Bone, Salivary Gland, Neutrophil

Publications for Root Caries

Articles related to Root Caries:

(show top 50) (show all 1013)
# Title Authors PMID Year
1
Treatment of multiple gingival recessions using subepithelial connective tissue grafting with a single-incision technique. 54 61
19550105 2009
2
Gingival recession in young adults: occurrence, severity, and relationship to past orthodontic treatment and oral piercing. 61 54
18984397 2008
3
Micromorphological and micronanalytical characterization of stagnating and progressing root caries lesions. 54 61
17181998 2007
4
Effect of flexural load cycling on microleakage of extended root caries restorations. 54 61
15853110 2005
5
Inhibition of human pulpal gelatinases (MMP-2 and MMP-9) by zinc oxide cements. 54 61
15210026 2004
6
Bonding to root caries by a self-etching adhesive system containing MDPB. 61 54
15151333 2004
7
Treatment of root caries lesions with chlorhexidine-containing varnishes and dentin sealants. 54 61
14674495 2003
8
[Effects of dentine phosphoprotein on remineralization of demineralized dentine]. 61 54
12839639 2003
9
Thermal and chemical modification of dentin by 9-11-microm CO2 laser pulses of 5-100-micros duration. 54 61
12355574 2002
10
[Effect of sodium chloride treatment on remineralization of human root dentine caries in vitro]. 61 54
11955357 2002
11
Mutans streptococci in subgingival plaque of treated and untreated patients with periodontitis. 61 54
11422591 2001
12
Effects of mutans streptococci, Actinomyces species and Porphyromonas gingivalis on collagen degradation. 61 54
10575804 1999
13
Molecular pathogenesis of root dentin caries. 61 54
10522203 1999
14
Closing of dentinal tubules by glutardialdehyde treatment, a scanning electron microscopy study. 61 54
8085120 1994
15
Prevention of root caries with dentin adhesives. 54 61
8054192 1994
16
Studies on newly designed tooth surface treatments for adhesive composite restoration. 61 54
1581999 1992
17
Structural events in the caries process in enamel, cementum, and dentin. 61 54
2179314 1990
18
The accuracy of laser fluorescence (DIAGNOdent) in assessing caries lesion activity on root surfaces, around crown margins, and in furcations in older adults. 61
33758162 2021
19
Peripheral Blood Mesenchymal Stem Cells and Platelet Rich Fibrin Matrix in the Management of Class II Gingival Recession: A Case Report. 61
33681425 2021
20
Dental Restorative Materials for Elderly Populations. 61
33800358 2021
21
Candida albicans promotes tooth decay by inducing oral microbial dysbiosis. 61
33149208 2021
22
Association between root/coronal caries and individual factors in institutionalised elderly using ICDAS severity and activity. 61
33752655 2021
23
In Silico Modeling of Hyposalivation and Biofilm Dysbiosis in Root Caries. 61
33749365 2021
24
Studies on antimicrobial peptide-loaded nanomaterial for root caries restorations to inhibit periodontitis related pathogens in periodontitis care. 61
33153344 2021
25
Refocusing dental care: A risk-based preventative oral health programme for dentate older people in UK care homes. 61
33586205 2021
26
In vitro Study of the Role of Human Neutrophil Enzymes on Root Caries Progression. 61
33582660 2021
27
Silver diamine fluoride treatment of active root caries lesions in older adults: A case series. 61
33347946 2021
28
Influence of Implant-Tooth Proximity on Incidence of Caries in Teeth Adjacent to Implants in Molar Sites: A Retrospective Radiographic Analysis of 300 Consecutive Implants. 61
33481625 2021
29
What are the main factors associated with root caries? 61
33772123 2021
30
Silver Diamine Fluoride (SDF) in the management of root caries in elders: a systematic review and meta-analysis. 61
33515230 2021
31
Oral Health-Related Quality of Life, Oral Conditions, and Risk of Malnutrition in Older German People in Need of Care-A Cross-Sectional Study. 61
33499288 2021
32
Remineralising effects of fluoride varnishes containing calcium phosphate on artificial root caries lesions with adjunctive application of proanthocyanidin. 61
33267974 2021
33
Oral health and functional capacity of centenarians. 61
33335144 2020
34
Tests to detect and inform the diagnosis of root caries. 61
33284484 2020
35
Thermal Imaging of Root Caries In Vivo. 61
32866422 2020
36
How to Intervene in the Caries Process in Older Adults: A Joint ORCA and EFCD Expert Delphi Consensus Statement. 61
33291110 2020
37
Prevalence and severity of periodontal disease in a historical Austrian population. 61
32658361 2020
38
The effect of dentin age on the microshear bond strength and microleakage of glass-ionomer cements. 61
33354808 2020
39
Basic properties of novel S-PRG filler-containing cement. 61
32611989 2020
40
Inequalities in Untreated Root Caries and Affordability of Dental Services among Older American Adults. 61
33212971 2020
41
Diabetes mellitus and poor glycemic control increase the occurrence of coronal and root caries: a systematic review and meta-analysis. 61
32829477 2020
42
The burden of root caries: Updated perspectives and advances on management strategies. 61
33236462 2020
43
Anti-caries effect of fluoridated milk-based drink consumed by older adults on an in vitro root caries experimental model. 61
32854060 2020
44
The diagnosis of active root caries is difficult. 61
33037371 2020
45
Some topical fluoride agents may result in a small decrease in root caries compared with no treatment after 2 years. 61
32768145 2020
46
Prevention and management of periodontal diseases and dental caries in the older adults. 61
32844424 2020
47
Treatment of gingival recession: when and how? 61
32974929 2020
48
Status of dental caries and associated factors in Tibetan adults: findings from the fourth China National Oral Health Survey. 61
32894126 2020
49
The relationship between sucrose intake in coffee or tea, and root or coronal caries in an elderly Japanese population. 61
32212434 2020
50
Concentration dependence of quaternary ammonium monomer on the design of high-performance bioactive composite for root caries restorations. 61
32527499 2020

Variations for Root Caries

Expression for Root Caries

Search GEO for disease gene expression data for Root Caries.

Pathways for Root Caries

GO Terms for Root Caries

Cellular components related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 STATH LTF DSPP DCD CST4 AMELX

Biological processes related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.58 STATH LTF DCD
2 cellular protein metabolic process GO:0044267 9.5 LTF AMELX ALB
3 antimicrobial humoral response GO:0019730 9.43 LTF DCD
4 killing of cells of other organism GO:0031640 9.37 LTF DCD
5 ossification GO:0001503 9.33 STATH LTF DSPP
6 positive regulation of collagen biosynthetic process GO:0032967 9.26 CBX8 AMELX
7 retina homeostasis GO:0001895 9.13 LTF CST4 ALB
8 biomineral tissue development GO:0031214 8.8 STATH DSPP AMELX

Molecular functions related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase inhibitor activity GO:0004869 9.16 LTF CST4
2 structural constituent of tooth enamel GO:0030345 8.96 STATH AMELX
3 hydroxyapatite binding GO:0046848 8.62 STATH AMELX

Sources for Root Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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