MCID: RTC003
MIFTS: 37

Root Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Root Caries

MalaCards integrated aliases for Root Caries:

Name: Root Caries 12 55 44 15 73
Dental Caries of Root Surface 12
Cementum Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14089
ICD9CM 35 521.08
MeSH 44 D017213
SNOMED-CT 68 234975001 30512007
ICD10 33 K02.2
UMLS 73 C0162644

Summaries for Root Caries

MalaCards based summary : Root Caries, also known as dental caries of root surface, is related to gingivitis and dental caries. An important gene associated with Root Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Iodine and Fluorides have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are homeostasis/metabolism and liver/biliary system

Related Diseases for Root Caries

Diseases related to Root Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 gingivitis 30.3 CD79A LTF
2 dental caries 29.6 CD79A DSPP LTF
3 aplasia of lacrimal and salivary glands 10.4 DSPP LTF
4 acute diarrhea 10.4 CD79A LTF
5 dentin caries 10.4 DSPP GPI
6 chickenpox 10.4 CD79A LTF
7 cork-handlers' disease 10.4 ALB CD79A
8 ostertagiasis 10.4 ALB CD79A
9 dermatitis, atopic, 3 10.4 ALB CD79A
10 orthostatic proteinuria 10.4 ALB CD79A
11 yellow nail syndrome 10.3 ALB CD79A
12 marasmus 10.3 ALB CD79A
13 chronic graft versus host disease 10.3 ALB CD79A
14 aging 10.3
15 diffuse glomerulonephritis 10.3 ALB CD79A
16 focal dermal hypoplasia 10.3 ALB CD79A
17 non-secretory myeloma 10.3 ALB CD79A
18 primary sjögren syndrome 10.3 CD79A LTF
19 hypersensitivity reaction type iii disease 10.3 ALB CD79A
20 shigellosis 10.3 CD79A LTF
21 protein-losing enteropathy 10.3 ALB CD79A
22 ulcerative stomatitis 10.3 ALB CD79A
23 pneumocystosis 10.3 ALB CD79A
24 autoimmune disease of urogenital tract 10.3 ALB CD79A
25 periodontitis 10.3
26 lipoid nephrosis 10.3 ALB CD79A
27 protein-energy malnutrition 10.3 ALB CD79A
28 meningoencephalitis 10.3 ALB CD79A
29 membranoproliferative glomerulonephritis 10.3 ALB CD79A
30 guillain-barre syndrome 10.2 ALB CD79A
31 extrinsic allergic alveolitis 10.2 ALB CD79A
32 obstructive jaundice 10.2 ALB CD79A
33 primary bacterial infectious disease 10.2 ALB CD79A
34 intestinal disease 10.2 ALB CD79A
35 mastitis 10.1 ALB LTF
36 hypersensitivity reaction disease 10.1 ALB CD79A
37 schistosomiasis 10.1 ALB CD79A
38 bronchitis 10.1 ALB CD79A
39 end stage renal failure 10.1 ALB CD79A
40 respiratory system disease 10.0 ALB CD79A
41 otitis media 10.0 ALB CD79A
42 periodontal disease 10.0
43 urinary system disease 10.0 ALB CD79A
44 diabetes mellitus 9.9
45 cervicitis 9.9
46 iga glomerulonephritis 9.9 ALB CD79A
47 parotitis 9.8 ALB CD79A LTF
48 dysentery 9.8 ALB CD79A LTF
49 acquired immunodeficiency syndrome 9.8 ALB CD79A
50 keratoconjunctivitis sicca 9.8 ALB CD79A LTF

Graphical network of the top 20 diseases related to Root Caries:



Diseases related to Root Caries

Symptoms & Phenotypes for Root Caries

MGI Mouse Phenotypes related to Root Caries:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ALB CD79A GPI LTF SMARCA2 SMARCA4
2 liver/biliary system MP:0005370 9.55 ALB CD79A GPI LTF SMARCA4
3 neoplasm MP:0002006 9.35 ALB CD79A LTF SMARCA2 SMARCA4
4 renal/urinary system MP:0005367 8.92 ALB CD79A SMARCA2 SMARCA4

Drugs & Therapeutics for Root Caries

Drugs for Root Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 2, Phase 3 7553-56-2 807
2 Fluorides Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
3 Protective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
4 Cariostatic Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
5 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3,Not Applicable
6
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
7
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
8 Anti-Bacterial Agents Not Applicable
9 Photosensitizing Agents Not Applicable
10 Anti-Infective Agents Not Applicable
11 Adrenergic Agents Not Applicable
12 Central Nervous System Stimulants Not Applicable
13 Neurotransmitter Agents Not Applicable
14 Neurotransmitter Uptake Inhibitors Not Applicable
15 Dopamine Agents Not Applicable
16 Dopamine Uptake Inhibitors Not Applicable
17 Peripheral Nervous System Agents Not Applicable
18 Autonomic Agents Not Applicable
19 Bone Density Conservation Agents Not Applicable
20 Calcium, Dietary Not Applicable
21 Acidophilus Nutraceutical Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas Completed NCT02742142 Phase 2, Phase 3 silver diammine fluoride
2 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults Completed NCT02360124 Phase 2, Phase 3 silver diammine fluoride
3 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed NCT00495495 Phase 2, Phase 3
4 Silver Diamine Fluoride and Gingivitis in Geriatric Patients Not yet recruiting NCT03445286 Phase 2 Chlorhexidine
5 Non-invasive Treatment of Root Caries in Older Adults Unknown status NCT02647203 Phase 1 Self-administered fluoridated dentifrices
6 Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF Completed NCT01738958 Not Applicable
7 Oral Health and People With Systemic Sclerosis Completed NCT01817361
8 Clinical Effect of Photoactivated Disinfection on Primary Root Carious Lesions After Partial Caries Removal Recruiting NCT03186352 Not Applicable
9 Intraoral Imaging at Clinical Crown Lengthening Recruiting NCT03064217 Not Applicable
10 Treatment of Root Caries in an Older Irish Population. Active, not recruiting NCT01866059 Not Applicable
11 Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers Active, not recruiting NCT03185104 Not Applicable Silver Diamine Fluoride;Distilled Water
12 Nobio Antimicrobial Particles Effect in a Split Mouth Model Not yet recruiting NCT03501784 Not Applicable

Search NIH Clinical Center for Root Caries

Cochrane evidence based reviews: root caries

Genetic Tests for Root Caries

Anatomical Context for Root Caries

MalaCards organs/tissues related to Root Caries:

41
Bone

Publications for Root Caries

Articles related to Root Caries:

(show top 50) (show all 341)
# Title Authors Year
1
Remineralization Potential of Mints Containing Bioactive Agents in Artificially Induced Root Caries. ( 29414808 )
2018
2
Cross-polarization reflectance imaging of root caries and dental calculus on extracted teeth at wavelengths from 400-2350-nm. ( 29952066 )
2018
3
Assessment of root caries under wet and dry conditions using swept-source optical coherence tomography (SS-OCT). ( 29962412 )
2018
4
Contextual and Individual Determinants of Root Caries in Older People. ( 29393150 )
2018
5
Cariogenicity of a Milk-Based Drink Used as a Dietary Supplement for Older Adults Using a Root Caries Experimental Model. ( 29945138 )
2018
6
Root caries prevention via sodium fluoride, chlorhexidine and silver diamine fluoride in vitro. ( 29387999 )
2018
7
Comparison of efficacy of dental varnish containing fluoride either with CPP-ACP or bioglass on root caries: Ex vivo study. ( 29673685 )
2018
8
Effect of Green Tea Varnish on Depth of Root Caries. ( 29422461 )
2018
9
Root caries: From prevalence to therapy. ( 29795505 )
2018
10
A literature review and hypothesis for the etiologies of cervical and root caries. ( 29349909 )
2018
11
Use of a Modified Matrix Band Technique to Restore Subgingival Root Caries. ( 29570028 )
2018
12
Systematic review finds that silver diamine fluoride is effective for both root caries prevention and arrest in older adults. ( 29930359 )
2018
13
Root caries incidence and increment in the population - a systematic review, meta-analysis and meta-regression of longitudinal studies. ( 29935998 )
2018
14
Gingival recession and root caries in the ageing population: a critical evaluation of treatments. ( 28266119 )
2017
15
Assessment of Root Caries Lesion Activity and Its Histopathological Features. ( 29050022 )
2017
16
Four-year incidence rate and predictors of root caries among community-dwelling south Brazilian older adults. ( 28921685 )
2017
17
Conventional Preventive Therapies (Fluoride) on Root Caries Lesions. ( 29050025 )
2017
18
State-of-the-art cosmetic restorative treatment for combating root caries. ( 28475077 )
2017
19
Endogenous Enzymes in Root Caries. ( 29050019 )
2017
20
Cost-effectiveness of root caries preventive treatments. ( 27984089 )
2017
21
Management of Cavitated Root Caries Lesions: Minimum Intervention and Alternatives. ( 29050028 )
2017
22
Association between Root Caries and Depressive Symptoms among Elders in Carlos Barbosa, RS, Brazil. ( 28492755 )
2017
23
Root caries experience among Australian adults. ( 28488339 )
2017
24
Evaluation of the Cariogram for root caries prediction. ( 28456556 )
2017
25
Incidence, Prevalence and Global Distribution of Root Caries. ( 29050015 )
2017
26
Monitoring of Root Caries Lesions. ( 29050023 )
2017
27
Synergistic effects of proanthocyanidin, tri-calcium phosphate and fluoride on artificial root caries and dentine collagen. ( 28183611 )
2017
28
Status and progress of treatment methods for root caries in the last decade: a literature review. ( 28833210 )
2017
29
Root caries analysis in working population of 35-44 years of age (Spain). ( 28809367 )
2017
30
Effectiveness of DIAGNOdent in Detecting Root Caries Without Dental Scaling Among Community-dwelling Elderly. ( 27957565 )
2016
31
Randomized clinical trial on arresting dental root caries through silver diamine fluoride applications in community-dwelling elders. ( 27713457 )
2016
32
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care. ( 26687774 )
2016
33
Prevalence of root caries among elders living in residential homes of Bengaluru city, India. ( 27398175 )
2016
34
INVESTIGATING THE ADDITION OF COLLAGEN AND ITS INTEGRIN BINDING SEQUENCE (RGD) TO GLASS POLYALKENOATE; IN TERMS OF MATERIAL AND CELLULAR PROPERTIES TO EXPLORE A MORE BIOCOMPATIBLE METHOD OF ROOT CARIES RESTORATION. ( 27662793 )
2016
35
Actinomyces spp. gene expression in root caries lesions. ( 27640531 )
2016
36
Randomized clinical trial on arresting dental root caries through silver diammine fluoride applications in community-dwelling elders. ( 27208876 )
2016
37
Ecological Hypothesis of Dentin and Root Caries. ( 27458979 )
2016
38
Activity assessment of root caries lesions with thermal and near-IR imaging methods. ( 27060450 )
2016
39
Ecological hypothesis of dentin and root caries. ( 27713451 )
2016
40
Risk indicators associated with root caries in independently living older adults. ( 27208875 )
2016
41
Clinical outcome of root caries restorations using ART and rotary techniques in institutionalized elders. ( 27253146 )
2016
42
A Predictive Model for Root Caries Incidence. ( 27160516 )
2016
43
Root caries: Risk indicators associated with root caries in independently living older adults. ( 27608575 )
2016
44
Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078422 )
2015
45
The Dietary Approaches to Stop Hypertension Diet and New and Recurrent Root Caries Events in Men. ( 26280256 )
2015
46
Root Caries: Causes, Prevention, and Treatment. ( 26775536 )
2015
47
Effect of over-the-counter fluoridated products regimens on root caries inhibition. ( 26299400 )
2015
48
Development of a multifunctional adhesive system for prevention of root caries and secondary caries. ( 26187532 )
2015
49
Root Caries in Older Adults. ( 26357814 )
2015
50
Topical agents for root caries prevention. ( 25909930 )
2015

Variations for Root Caries

Expression for Root Caries

Search GEO for disease gene expression data for Root Caries.

Pathways for Root Caries

Pathways related to Root Caries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Root Caries

Cellular components related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.26 DSPP LTF
2 humoral immune response GO:0006959 9.16 GPI LTF
3 retina homeostasis GO:0001895 8.96 ALB LTF
4 ATP-dependent chromatin remodeling GO:0043044 8.62 SMARCA2 SMARCA4

Molecular functions related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-dependent ATPase activity GO:0008094 8.96 SMARCA2 SMARCA4
2 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Root Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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