MCID: RTC003
MIFTS: 39

Root Caries

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Root Caries

MalaCards integrated aliases for Root Caries:

Name: Root Caries 12 55 44 15 73
Dental Caries of Root Surface 12
Cementum Caries 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14089
ICD9CM 35 521.08
MeSH 44 D017213
SNOMED-CT 68 30512007
ICD10 33 K02.2
UMLS 73 C0162644

Summaries for Root Caries

MalaCards based summary : Root Caries, also known as dental caries of root surface, is related to dental caries and aplasia of lacrimal and salivary glands. An important gene associated with Root Caries is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are BRCA1 Pathway and Transcription Ligand-dependent activation of the ESR1/SP pathway. The drugs Iodine and Cariostatic Agents have been mentioned in the context of this disorder. Affiliated tissues include bone and salivary gland, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Root Caries

Diseases related to Root Caries via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 dental caries 29.7 CD79A DSPP LTF
2 aplasia of lacrimal and salivary glands 10.1 DSPP LTF
3 periodontal disease 10.1
4 chronic graft versus host disease 10.1 ALB CD79A
5 focal dermal hypoplasia 10.1 ALB CD79A
6 protein-losing enteropathy 10.1 ALB CD79A
7 ulcerative stomatitis 10.1 ALB CD79A
8 hypersensitivity reaction type iii disease 10.1 ALB CD79A
9 lipoid nephrosis 10.1 ALB CD79A
10 meningoencephalitis 10.0 ALB CD79A
11 membranoproliferative glomerulonephritis 10.0 ALB CD79A
12 dysentery 10.0 ALB LTF
13 guillain-barre syndrome 10.0 ALB CD79A
14 iga glomerulonephritis 10.0 ALB CD79A
15 diabetes mellitus 10.0
16 mastitis 10.0 ALB LTF
17 otitis media 10.0 ALB CD79A
18 cholangitis, primary sclerosing 10.0 ALB LTF
19 membranous nephropathy 9.9 ALB CD79A
20 lymphosarcoma 9.9 CD79A SMARCA4
21 parotitis 9.9 ALB CD79A LTF
22 keratoconjunctivitis sicca 9.9 ALB CD79A LTF
23 alpha thalassemia-x-linked intellectual disability syndrome 9.9 SMARCA2 SMARCA4
24 schimke immunoosseous dysplasia 9.9 SMARCA2 SMARCA4
25 teeth hard tissue disease 9.9 DSPP GPI SMARCA2
26 alzheimer disease 9.9
27 diabetes mellitus, noninsulin-dependent 9.9
28 gingival recession 9.9
29 endocarditis 9.9
30 periodontitis 9.9
31 borjeson-forssman-lehmann syndrome 9.8 SMARCA2 SMARCA4
32 small cell carcinoma 9.8 SMARCA2 SMARCA4
33 gastrointestinal system disease 9.8 ALB LTF
34 coffin-siris syndrome 1 9.8 SMARCA2 SMARCA4
35 autosomal dominant non-syndromic intellectual disability 9.7 SMARCA2 SMARCA4
36 enamel erosion 9.7 GPI SMARCA2 SMARCA4
37 gingival disease 9.7 GPI SMARCA2 SMARCA4
38 tooth erosion 9.6 DSPP GPI SMARCA2 SMARCA4

Graphical network of the top 20 diseases related to Root Caries:



Diseases related to Root Caries

Symptoms & Phenotypes for Root Caries

GenomeRNAi Phenotypes related to Root Caries according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 CD79A LTF
2 Decreased viability GR00381-A-3 9.1 CD79A LTF
3 Decreased viability GR00402-S-2 9.1 CD79A LTF

MGI Mouse Phenotypes related to Root Caries:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ALB CD79A GPI LTF SMARCA2 SMARCA4
2 liver/biliary system MP:0005370 9.55 ALB CD79A GPI LTF SMARCA4
3 neoplasm MP:0002006 9.35 ALB CD79A LTF SMARCA2 SMARCA4
4 renal/urinary system MP:0005367 8.92 ALB CD79A SMARCA2 SMARCA4

Drugs & Therapeutics for Root Caries

Drugs for Root Caries (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 2, Phase 3,Not Applicable 7553-56-2 807
2 Cariostatic Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
3 Protective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
4 Fluorides Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
5 Pharmaceutical Solutions Phase 2, Phase 3,Phase 3,Not Applicable
6
Imidacloprid Vet_approved Phase 2 105827-78-9 86418
7 Antihypertensive Agents Phase 2
8
Dopamine Approved Not Applicable 51-61-6, 62-31-7 681
9
Methamphetamine Approved, Illicit Not Applicable 537-46-2 10836
10
Povidone-iodine Approved Not Applicable 25655-41-8
11
Povidone Approved Not Applicable 9003-39-8
12 sodium fluoride Approved Not Applicable 7681-49-4
13 Calcium, Dietary Not Applicable
14 Neurotransmitter Agents Not Applicable
15 Neurotransmitter Uptake Inhibitors Not Applicable
16 Central Nervous System Stimulants Not Applicable
17 Sympathomimetics Not Applicable
18 Dopamine Uptake Inhibitors Not Applicable
19 Dopamine Agents Not Applicable
20 Bone Density Conservation Agents Not Applicable
21 Autonomic Agents Not Applicable
22 Peripheral Nervous System Agents Not Applicable
23 Adrenergic Agents Not Applicable
24 Acidophilus Not Applicable
25 Anti-Bacterial Agents Not Applicable
26 Photosensitizing Agents Not Applicable
27 Anti-Infective Agents Not Applicable
28 Fluorides, Topical Not Applicable
29 Anti-Infective Agents, Local Not Applicable
30 cadexomer iodine Not Applicable
31 Plasma Substitutes Not Applicable
32 Listerine Not Applicable
33 Blood Substitutes Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Fluoride Application on Preventing and Arresting Root Caries in Fluoridated and Non-fluoridated Areas Completed NCT02742142 Phase 2, Phase 3 silver diammine fluoride
2 Preventing and Arresting Dental Root Surface Caries in Community-dwelling Older Adults Completed NCT02360124 Phase 2, Phase 3 silver diammine fluoride
3 Healozone Study to Evaluate the Safety and Efficacy of the Use of Ozone for Management of Dental Caries Completed NCT00495495 Phase 2, Phase 3
4 Photobiomodulation in Salivary Production of Patients With Xerostomy Recruiting NCT03632096 Phase 2
5 Silver Diamine Fluoride and Gingivitis in Geriatric Patients Not yet recruiting NCT03445286 Phase 2
6 Non-invasive Treatment of Root Caries in Older Adults Unknown status NCT02647203 Phase 1 Self-administered fluoridated dentifrices
7 Treatment of Root Caries in an Older Irish Population. Unknown status NCT01866059 Not Applicable
8 Effect of Lozenges Containing Probiotic Lactobacilli on Enamel Demineralization Assed by QLF Completed NCT01738958 Not Applicable
9 Oral Health and People With Systemic Sclerosis Completed NCT01817361
10 Clinical Effect of Photoactivated Disinfection on Primary Root Carious Lesions After Partial Caries Removal Recruiting NCT03186352 Not Applicable
11 Intraoral Imaging at Clinical Crown Lengthening Recruiting NCT03064217 Not Applicable
12 Effectiveness on SDF Solution and PVP-I Combined NaF Varnish in Preventing Root Caries in Elders Active, not recruiting NCT03654820 Not Applicable
13 24-Month Clinical Performance of Different Restorative Materials in the Treatment of Root Caries Lesions Active, not recruiting NCT03722758 Not Applicable
14 5-year Clinical Evaluation of Cavity Lining on the Restoration Active, not recruiting NCT03802539 Not Applicable
15 Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers Active, not recruiting NCT03185104 Not Applicable Silver Diamine Fluoride;Distilled Water
16 Evaluation of Gingival Health Parameters in Hybrid CAD / CAM Crowns Produced After Different Retraction Processes Active, not recruiting NCT03816930 Not Applicable
17 Nobio Antimicrobial Particles Effect in a Split Mouth Model Not yet recruiting NCT03501784 Not Applicable

Search NIH Clinical Center for Root Caries

Cochrane evidence based reviews: root caries

Genetic Tests for Root Caries

Anatomical Context for Root Caries

MalaCards organs/tissues related to Root Caries:

41
Bone, Salivary Gland

Publications for Root Caries

Articles related to Root Caries:

(show top 50) (show all 349)
# Title Authors Year
1
Remineralization Potential of Mints Containing Bioactive Agents in Artificially Induced Root Caries. ( 29414808 )
2018
2
Cross-polarization reflectance imaging of root caries and dental calculus on extracted teeth at wavelengths from 400-2350-nm. ( 29952066 )
2018
3
Assessment of root caries under wet and dry conditions using swept-source optical coherence tomography (SS-OCT). ( 29962412 )
2018
4
Contextual and Individual Determinants of Root Caries in Older People. ( 29393150 )
2018
5
Cariogenicity of a Milk-Based Drink Used as a Dietary Supplement for Older Adults Using a Root Caries Experimental Model. ( 29945138 )
2018
6
Root caries prevention via sodium fluoride, chlorhexidine and silver diamine fluoride in vitro. ( 29387999 )
2018
7
Comparison of efficacy of dental varnish containing fluoride either with CPP-ACP or bioglass on root caries: Ex vivo study. ( 29673685 )
2018
8
Effect of Green Tea Varnish on Depth of Root Caries. ( 29422461 )
2018
9
Root caries: From prevalence to therapy. ( 29795505 )
2018
10
A literature review and hypothesis for the etiologies of cervical and root caries. ( 29349909 )
2018
11
Use of a Modified Matrix Band Technique to Restore Subgingival Root Caries. ( 29570028 )
2018
12
Novel multifunctional nanocomposite for root caries restorations to inhibit periodontitis-related pathogens. ( 30552930 )
2018
13
Systematic review finds that silver diamine fluoride is effective for both root caries prevention and arrest in older adults. ( 29930359 )
2018
14
Root caries incidence and increment in the population - A systematic review, meta-analysis and meta-regression of longitudinal studies. ( 29935998 )
2018
15
Assessment of oral health-related quality of life as a function of non-invasive treatment with high-fluoride toothpastes for root caries lesions in community-dwelling elderly. ( 30028021 )
2018
16
Silver diamine fluoride seems to be effective in preventing and arresting root caries in older adults compared with placebo, but there is very low certainty in the magnitude of the benefit. ( 30119828 )
2018
17
Root caries experience in Germany 1997 to 2014: Analysis of trends and identification of risk factors. ( 30165190 )
2018
18
How Root Caries Differs between Middle-aged People and the Elderly: Findings from the 4th National Oral Health Survey of China. ( 30255173 )
2018
19
Gingival recession and root caries in the ageing population: a critical evaluation of treatments. ( 28266119 )
2017
20
Assessment of Root Caries Lesion Activity and Its Histopathological Features. ( 29050022 )
2017
21
Four-year incidence rate and predictors of root caries among community-dwelling south Brazilian older adults. ( 28921685 )
2017
22
Conventional Preventive Therapies (Fluoride) on Root Caries Lesions. ( 29050025 )
2017
23
State-of-the-art cosmetic restorative treatment for combating root caries. ( 28475077 )
2017
24
Endogenous Enzymes in Root Caries. ( 29050019 )
2017
25
Cost-effectiveness of root caries preventive treatments. ( 27984089 )
2017
26
Management of Cavitated Root Caries Lesions: Minimum Intervention and Alternatives. ( 29050028 )
2017
27
Association between Root Caries and Depressive Symptoms among Elders in Carlos Barbosa, RS, Brazil. ( 28492755 )
2017
28
Root caries experience among Australian adults. ( 28488339 )
2017
29
Evaluation of the Cariogram for root caries prediction. ( 28456556 )
2017
30
Incidence, Prevalence and Global Distribution of Root Caries. ( 29050015 )
2017
31
Monitoring of Root Caries Lesions. ( 29050023 )
2017
32
Synergistic effects of proanthocyanidin, tri-calcium phosphate and fluoride on artificial root caries and dentine collagen. ( 28183611 )
2017
33
Status and progress of treatment methods for root caries in the last decade: a literature review. ( 28833210 )
2017
34
Root caries analysis in working population of 35-44 years of age (Spain). ( 28809367 )
2017
35
Effectiveness of DIAGNOdent in Detecting Root Caries Without Dental Scaling Among Community-dwelling Elderly. ( 27957565 )
2016
36
Randomized clinical trial on arresting dental root caries through silver diamine fluoride applications in community-dwelling elders. ( 27713457 )
2016
37
An alternate technique of care using silver fluoride followed by stannous fluoride in the management of root caries in aged care. ( 26687774 )
2016
38
Prevalence of root caries among elders living in residential homes of Bengaluru city, India. ( 27398175 )
2016
39
INVESTIGATING THE ADDITION OF COLLAGEN AND ITS INTEGRIN BINDING SEQUENCE (RGD) TO GLASS POLYALKENOATE; IN TERMS OF MATERIAL AND CELLULAR PROPERTIES TO EXPLORE A MORE BIOCOMPATIBLE METHOD OF ROOT CARIES RESTORATION. ( 27662793 )
2016
40
Actinomyces spp. gene expression in root caries lesions. ( 27640531 )
2016
41
Randomized clinical trial on arresting dental root caries through silver diammine fluoride applications in community-dwelling elders. ( 27208876 )
2016
42
Ecological Hypothesis of Dentin and Root Caries. ( 27458979 )
2016
43
Activity assessment of root caries lesions with thermal and near-IR imaging methods. ( 27060450 )
2016
44
Ecological hypothesis of dentin and root caries. ( 27713451 )
2016
45
Risk indicators associated with root caries in independently living older adults. ( 27208875 )
2016
46
Clinical outcome of root caries restorations using ART and rotary techniques in institutionalized elders. ( 27253146 )
2016
47
A Predictive Model for Root Caries Incidence. ( 27160516 )
2016
48
Root caries: Risk indicators associated with root caries in independently living older adults. ( 27608575 )
2016
49
Letter to the Editor, "Systematic Review on Noninvasive Treatment of Root Caries Lesions". ( 26078422 )
2015
50
The Dietary Approaches to Stop Hypertension Diet and New and Recurrent Root Caries Events in Men. ( 26280256 )
2015

Variations for Root Caries

Expression for Root Caries

Search GEO for disease gene expression data for Root Caries.

Pathways for Root Caries

Pathways related to Root Caries according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 SMARCA2 SMARCA4
2
Show member pathways
10.47 SMARCA2 SMARCA4

GO Terms for Root Caries

Cellular components related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA2 SMARCA4
2 nBAF complex GO:0071565 8.96 SMARCA2 SMARCA4
3 npBAF complex GO:0071564 8.62 SMARCA2 SMARCA4

Biological processes related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.32 DSPP LTF
2 chromatin remodeling GO:0006338 9.26 SMARCA2 SMARCA4
3 humoral immune response GO:0006959 9.16 GPI LTF
4 retina homeostasis GO:0001895 8.96 ALB LTF
5 ATP-dependent chromatin remodeling GO:0043044 8.62 SMARCA2 SMARCA4

Molecular functions related to Root Caries according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-dependent ATPase activity GO:0008094 8.96 SMARCA2 SMARCA4
2 hydrolase activity, acting on acid anhydrides GO:0016817 8.62 SMARCA2 SMARCA4

Sources for Root Caries

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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