MCID: RTR008
MIFTS: 47

Root Resorption

Categories: Oral diseases

Aliases & Classifications for Root Resorption

MalaCards integrated aliases for Root Resorption:

Name: Root Resorption 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14550
MeSH 44 D012391
UMLS 73 C0035851

Summaries for Root Resorption

MalaCards based summary : Root Resorption is related to tooth resorption and chronic apical periodontitis. An important gene associated with Root Resorption is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Chlorhexidine and Zinc have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and thyroid, and related phenotypes are hematopoietic system and growth/size/body region

Related Diseases for Root Resorption

Diseases related to Root Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 tooth resorption 31.4 CTSK DSPP TNFRSF11A TNFRSF11B TNFSF11
2 chronic apical periodontitis 30.1 TNFRSF11B TNFSF11
3 periodontitis 29.8 CTSK IL1A IL1B RUNX2 TNFRSF11B TNFSF11
4 pulpitis 29.7 DSPP IL1A IL1B
5 periodontal disease 29.5 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
6 hypercementosis 29.5 CTSK DSPP SPP1 TNFRSF11A
7 periapical periodontitis 29.5 DSPP IL1B TNFRSF11A TNFRSF11B TNFSF11
8 bone resorption disease 29.1 CALCA CTSK RUNX2 SPP1 TNFRSF11A TNFRSF11B
9 singleton-merten syndrome 1 11.1
10 ankylosis 10.3
11 prosthetic joint infection 10.2 IL1B TNFRSF11B
12 multicentric reticulohistiocytosis 10.2 TNFRSF11B TNFSF11
13 breast leiomyosarcoma 10.2 TNFRSF11A TNFSF11
14 kummell's disease 10.2 TNFRSF11B TNFSF11
15 osteopetrosis, autosomal recessive 7 10.2 TNFRSF11A TNFSF11
16 erdheim-chester disease 10.2 IL1B TNFSF11
17 vulvar vestibulitis syndrome 10.2 IL1B IL1RN
18 gastric cancer, hereditary diffuse 10.2 IL1B IL1RN
19 schnitzler syndrome 10.2 IL1B IL1RN
20 fibrogenesis imperfecta ossium 10.2 CALCA TNFRSF11B
21 osteosclerotic myeloma 10.2 IL1B IL1RN
22 periostitis 10.2 IL1RN TNFRSF11A
23 osteopetrosis, autosomal recessive 2 10.2 TNFRSF11A TNFSF11
24 chronic follicular conjunctivitis 10.2 IL1A IL1B
25 giant cell reparative granuloma 10.2 CALCA TNFRSF11A
26 acute cholangitis 10.2 CALCA IL1RN
27 periodontitis, chronic 10.1 IL1B TNFRSF11B TNFSF11
28 polyarticular onset juvenile idiopathic arthritis 10.1 TNFRSF11A TNFRSF11B TNFSF11
29 hemophilic arthropathy 10.1 TNFRSF11A TNFRSF11B TNFSF11
30 amyloid tumor 10.1 CALCA IL1RN
31 hydrarthrosis 10.1 IL1B IL1RN
32 familial expansile osteolysis 10.1 TNFRSF11A TNFRSF11B TNFSF11
33 joint disorders 10.1 IL1B IL1RN TNFSF11
34 irritant dermatitis 10.1 IL1A IL1B
35 cinca syndrome 10.1 IL1B IL1RN
36 dentin dysplasia, type ii 10.1 DSPP SPP1
37 dentin dysplasia 10.1 DSPP SPP1
38 aseptic meningitis 10.1 IL1B IL1RN
39 hypophosphatasia, adult 10.1 CALCA SPP1
40 stachybotrys chartarum 10.1 IL1A IL1B
41 limbal stem cell deficiency 10.1 IL1A IL1B
42 aneurysmal bone cysts 10.1 CALCA TNFRSF11A TNFSF11
43 dental pulp calcification 10.1 DSPP SPP1
44 endometrial disease 10.1 DSPP IL1B
45 dental pulp disease 10.1 DSPP IL1B
46 endosteal hyperostosis, autosomal dominant 10.1 CTSK TNFRSF11B TNFSF11
47 osteopetrosis 10.1 CTSK TNFRSF11A TNFSF11
48 secondary hyperparathyroidism of renal origin 10.1 CALCA TNFRSF11B
49 meningococcemia 10.0 IL1A IL1B IL1RN
50 idiopathic neutropenia 10.0 IL1A IL1B IL1RN

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to Root Resorption

Symptoms & Phenotypes for Root Resorption

MGI Mouse Phenotypes related to Root Resorption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CTSK IL1A IL1B IL1RN P2RX7 RUNX2
2 growth/size/body region MP:0005378 10.09 CTSK IL1B IL1RN P2RX7 RUNX2 SPP1
3 cardiovascular system MP:0005385 10.02 IL1A IL1B IL1RN P2RX7 RUNX2 SPP1
4 homeostasis/metabolism MP:0005376 10.02 CTSK IL1A IL1B IL1RN P2RX7 RUNX2
5 immune system MP:0005387 10.02 CTSK IL1A IL1B IL1RN P2RX7 RUNX2
6 craniofacial MP:0005382 10 CTSK IL1B RUNX2 SPP1 TNFRSF11A TNFRSF11B
7 integument MP:0010771 9.86 IL1A IL1B IL1RN P2RX7 RUNX2 SPP1
8 limbs/digits/tail MP:0005371 9.63 CTSK P2RX7 RUNX2 TNFRSF11A TNFRSF11B TNFSF11
9 neoplasm MP:0002006 9.35 IL1A IL1B SPP1 TNFRSF11A TNFSF11
10 skeleton MP:0005390 9.28 CTSK IL1B IL1RN P2RX7 RUNX2 SPP1

Drugs & Therapeutics for Root Resorption

Drugs for Root Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 2,Not Applicable 55-56-1 2713 9552079
2
Zinc Approved, Investigational Phase 2,Not Applicable 7440-66-6
3
Ethanol Approved Phase 2 64-17-5 702
4
Tetracycline Approved, Vet_approved Phase 2 60-54-8 5353990
5
Zinc oxide Approved Phase 2,Not Applicable 1314-13-2
6
Eugenol Approved Phase 2,Not Applicable 97-53-0 3314
7
Chloramphenicol Approved, Vet_approved Phase 2 56-75-7 5959 298
8
Chloramphenicol succinate Experimental Phase 2 3544-94-3
9 Anti-Infective Agents Phase 2,Early Phase 1,Not Applicable
10 Dermatologic Agents Phase 2,Not Applicable
11 Chlorhexidine gluconate Phase 2,Not Applicable
12 Pharmaceutical Solutions Phase 2,Not Applicable
13 Sunscreening Agents Phase 2
14 Radiation-Protective Agents Phase 2
15 Protective Agents Phase 2
16 Mitogens Phase 1
17
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
18
Racepinephrine Approved Not Applicable 329-65-7 838
19
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
20
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
21
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
22
Copper Approved, Investigational Not Applicable 7440-50-8 27099
23 Orange Approved Not Applicable
24
Alginic acid Approved, Investigational Not Applicable 9005-32-7
25
Calcium Carbonate Approved, Investigational Not Applicable 471-34-1
26
Formaldehyde Approved, Vet_approved Not Applicable 50-00-0 712
27
Simvastatin Approved Not Applicable 79902-63-9 54454
28
Neomycin Approved, Vet_approved Not Applicable 1404-04-2 8378
29
Bacitracin Approved, Vet_approved Not Applicable 1405-87-4 10909430 439542
30 Anesthetics, Local Not Applicable
31 Anesthetics Not Applicable
32 Disinfectants Early Phase 1,Not Applicable
33 Eusol Early Phase 1,Not Applicable
34 Sodium hypochlorite Early Phase 1,Not Applicable
35 Calcium, Dietary Not Applicable
36 Epinephryl borate Not Applicable
37 Keratolytic Agents Not Applicable
38 Antifungal Agents Not Applicable
39 Central Nervous System Depressants Not Applicable
40 Anti-Inflammatory Agents Not Applicable
41 Analgesics Not Applicable
42
Nickel Not Applicable 7440-02-0 934
43 Bone Density Conservation Agents Not Applicable
44 Anti-Bacterial Agents Not Applicable
45 Antibiotics, Antitubercular Not Applicable
46 Hypolipidemic Agents Not Applicable
47 Bacitracin zinc, neomycin sulfate, polymyxin B, drug combination Not Applicable
48 Polymyxins Not Applicable
49 Lipid Regulating Agents Not Applicable
50 Polymyxin B Not Applicable

Interventional clinical trials:

(show top 50) (show all 74)
# Name Status NCT ID Phase Drugs
1 MEDCEM PC and MTA in Pulpotomies of Primary Molars Unknown status NCT02291120 Phase 4
2 Indirect Pulp Treatment in Primary Molars Completed NCT03770871 Phase 4 Dycal (Indirect pulp treatment);Vitrebond (Indirect pulp treatment)
3 Vital Pulp Treatment in Primary Teeth Recruiting NCT02298504 Phase 4 Mineral Trioxide Aggregate;Biodentin;Vitrebond
4 Light Cured Resin Modified Calcium Silicate Versus Light Cured Calcium Hydroxide in Indirect Pulp Treatment of Primary Molars Not yet recruiting NCT03791255 Phase 4 Calcium silicate liner;Calcium hydroxide liner
5 Biodentine Versus White MTA Pulpotomy Unknown status NCT01733420 Phase 3 Biodentine pulpotomy;White MTA pulpotomy;Tempophore pulpotomy
6 Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial Completed NCT02216942 Phase 3 Endodontic treatment using Vitapex;Endodontic treatment using Guedes Pinto
7 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound Unknown status NCT00423956 Phase 1, Phase 2
8 Histological Change of The Dentinal-Pulp Complex and Root Resorption Completed NCT01642693 Phase 1, Phase 2
9 Endodontic Treatment of Primary Teeth Using Mineral Trioxide Aggregate Paste Completed NCT02887456 Phase 2 Endodontic treatment using Vitapex;Endodontic treatment using MTA paste
10 Root Canal Treatment in Primary Molars With Necrotic Pulp Using Two Different Pulp Therapies Recruiting NCT03650036 Phase 2 Pulp Therapy CTZ Paste;Pulp Therapy ZOE Paste
11 Regenerative Ability of TAMP BG and BD in Pulpotomized Primary Teeth Terminated NCT03786302 Phase 2 TAMP bioglass;Biodentine
12 Use of PRP in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
13 Periodontal Ligament Stress Level and Tooth Movement Completed NCT00099814 Phase 1
14 Labial Alveolar Bone Thickness and Apical Root Resorption Changes Associated With Self-ligating Versus Conventional Brackets Unknown status NCT02816489 Not Applicable
15 Volumetric Analysis of Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206 Not Applicable
16 Periodontally Accelerated Orthodontics - A Novel Technique For a Shortened Orthodontic Treatment With a Stable Result. A Clinical and Computerized Tomography Analysis Unknown status NCT01628575
17 Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) - Based Planning and Creation of Orthodontic Appliances Unknown status NCT00871026 Not Applicable
18 Sodium Hypochlorite Pulpotomies in Primary Molars: Comparison With Conventional 20% Formocresol Pulpotomies Unknown status NCT02137967 Early Phase 1 2.5% NaOCl;20% Formocresol
19 Evaluation of Pulp Symptoms After Minimal Caries Removal in Treatment of Deep Caries Unknown status NCT02918903 Not Applicable
20 A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets Completed NCT03613285 Not Applicable
21 Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment Completed NCT02745626 Not Applicable
22 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Radiographs Completed NCT02822040
23 Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars Completed NCT03119779 Not Applicable MTA-Anglus;TheraCal
24 The Effect of Ultrasound on Orthodontic Tooth Movement Completed NCT01828164 Not Applicable
25 Micro-osteoperforations and Tooth Movement Completed NCT02473471 Not Applicable
26 Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth Completed NCT02740907
27 Assessment of Piezoelectric Periodontal Surgery Effects on Orthodontic Treatment: a Prospective Pilot Study Completed NCT02359760 Not Applicable
28 Checking Occlusion During Stainless Steel Crown Placement Completed NCT02437565 Not Applicable
29 Efficiency of Piezocision-assisted Orthodontic Treatment in Adult Patients Completed NCT02590835 Not Applicable
30 The Effect of Different Force Magnitudes on Maxillary Posterior Segment Intrusion Completed NCT02901678 Not Applicable
31 The Use of Corticotomy for Upper Incisors Retraction Completed NCT03149016 Not Applicable
32 Treatment of Crowding Without Extraction Using Self Ligating Brackets Completed NCT02996292 Not Applicable
33 Intermittent Vibrational Force and Orthodontic Tooth Movement Completed NCT02314975 Not Applicable
34 Acceleration of Lower Anterior Teeth Leveling and Alignment Using Corticision Completed NCT03310086 Not Applicable
35 Effect of Liners on Pulpal Outcome and Restoration Survival After Partial Caries Excavation Completed NCT03286959 Not Applicable
36 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291 Not Applicable
37 Clinical and Radiographic Evaluation of Biodentine Versus Formocresol Completed NCT03582319 Not Applicable
38 The Effect of Laser Combined With Pulp-capping Agents on Direct Pulp Capping Completed NCT02487329 Not Applicable
39 Clinical and Radiographic Evaluation of Indirect Pulp Capping in Primary and Permanent Teeth With Different Materials Completed NCT03606681 Not Applicable Calcium Hydroxide;Mineral Trioxide Aggregate;TheraCal LC
40 Effect of Micro-osteoperforation on the Rate of Canine Retraction Completed NCT03450278 Not Applicable
41 Evaluation of Post Operative Pain Following Indirect Pulp Capping Using Antibacterial Bonding System Completed NCT02930135 Not Applicable
42 Low-level Laser Therapy Versus Formocresol in Primary Molar Pulpotomies Completed NCT03782714 Not Applicable
43 Evaluation of Periodontal Ligament Distraction Using a Modified Surgical Technique for Retraction of Maxillary Canines Completed NCT03535285 Not Applicable
44 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229 Not Applicable
45 0.018 or 0.022 Bracket Slot System More Effective in Orthodontic Treatment? Completed NCT02080338 Not Applicable
46 Correlation Between Root Resorption and Dentin Sialoprotein Upon Application of Different Orthodontic Forces. Recruiting NCT03644537 Not Applicable
47 Efficacy of Injectable Platelet Rich Fibrin (i-PRF) in Enhancing Bone Quality Recruiting NCT03399760 Not Applicable
48 Evaluation of the Effects of Osteoperforation and Piezocorticision on Canine Retraction Recruiting NCT03308851 Not Applicable
49 The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances Recruiting NCT03202355 Not Applicable
50 Assessment of Vital Pulp Therapy in Permanent Molars Recruiting NCT03410134 Not Applicable

Search NIH Clinical Center for Root Resorption

Cochrane evidence based reviews: root resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

MalaCards organs/tissues related to Root Resorption:

41
Bone, Colon, Thyroid, Heart, Kidney, Tonsil

Publications for Root Resorption

Articles related to Root Resorption:

(show top 50) (show all 1005)
# Title Authors Year
1
Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats. ( 29607672 )
2018
2
The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis. ( 29617793 )
2018
3
Factors Associated to Apical Root Resorption after Orthodontic Treatment. ( 29875885 )
2018
4
Volumetric evaluation of root resorption on the upper incisors using cone beam computed tomography after 1 year of orthodontic treatment in adult patients with marginal bone loss. ( 29911905 )
2018
5
A comparative study of the effect of the intrusion arch and straight wire mechanics on incisor root resorption: A randomized, controlled trial. ( 28985106 )
2018
6
Root resorption due to orthodontic treatment using self-ligating and conventional brackets : AA cone-beam computed tomography study. ( 29651519 )
2018
7
Evaluation of orthodontically induced external root resorption following orthodontic treatment using cone beam computed tomography (CBCT): a systematic review and meta-analysis. ( 29771300 )
2018
8
Apical root resorption during orthodontic treatment with clear aligners: A retrospective study using cone-beam computed tomography. ( 29853242 )
2018
9
Accuracy of Digital Periapical Radiography and Cone-beam Computed Tomography for Diagnosis of Natural and Simulated External Root Resorption. ( 29884337 )
2018
10
Comparison between Two Radiological Methods for Assessment of Tooth Root Resorption: An In Vitro Study. ( 29687001 )
2018
11
Obturation quality of calcium silicate-based cements placed with different techniques in teeth with perforating internal root resorption: a micro-computed tomographic study. ( 29872920 )
2018
12
Evaluation of root resorption after comprehensive orthodontic treatment using cone beam computed tomography (CBCT): a meta-analysis. ( 29945577 )
2018
13
Effect of EMD on the orthodontically induced root resorption repair process in rats. ( 29396597 )
2018
14
The ins and outs of root resorption. ( 29747189 )
2018
15
Incidence of Root Resorption after the Replantation of Avulsed Teeth: A Meta-analysis. ( 29866405 )
2018
16
The effects of three modified Hank's balanced salt solutions on root resorption of late replanted teeth: A pilot study. ( 29545029 )
2018
17
Physical properties of root cementum: Part 26. Effects of micro-osteoperforations on orthodontic root resorption: A microcomputed tomography study. ( 29407497 )
2018
18
Intrinsic Hormone-Like Molecules and External Root Resorption During Orthodontic Tooth Movement. A Systematic Review and Meta-Analysis in Preclinical <i>in-Vivo</i> Research. ( 29643818 )
2018
19
Autotransplantation, Surgical Repositioning of Retained Canine, and Apical Filling of Two Incisors with Root Resorption. ( 29707027 )
2018
20
Bilateral root resorption of maxillary i-8rst permanent molars by unerupted second molars associated with orthodontic distalisation. ( 29976113 )
2018
21
A pilot study of the metabolomic profiles of saliva from female orthodontic patients with external apical root resorption. ( 29291387 )
2018
22
Effects of loxoprofen on the apical root resorption during orthodontic tooth movement in rats. ( 29694352 )
2018
23
External apical root resorption. ( 29287651 )
2018
24
Antagonistic effect of IL1 variants in periodontitis and external apical root resorption: Evidence from a literature review. ( 30142580 )
2018
25
Effects of systemic medication on root resorption associated with orthodontic tooth movement: a systematic review of animal studies. ( 29992228 )
2018
26
Effect of caspases and RANKL induced by heavy force in orthodontic root resorption. ( 30003059 )
2018
27
Apical root displacement is a critical risk factor for apical root resorption after orthodontic treatment. ( 30124322 )
2018
28
Effect of continuous versus intermittent orthodontic forces on root resorption: A microcomputed tomography study. ( 30124325 )
2018
29
To what extent are impacted canines associated with root resorption of the adjacent tooth?: A systematic review with meta-analysis. ( 30165975 )
2018
30
Physical properties of root cementum: Part 27. Effect of low-level laser therapy on the repair of orthodontically induced inflammatory root resorption: A double-blind, split-mouth, randomized controlled clinical trial. ( 30173835 )
2018
31
Effects of continuous force application for extrusive tipping movement on periapical root resorption in the rat mandibular first molar. ( 30206533 )
2018
32
Case Report: Root resorption caused after pulp death of adjacent primary molar. ( 30228878 )
2018
33
There is probably high variability in the incidence of root resorption after replantation of avulsed teeth across and within types of teeth and resorption. ( 30241921 )
2018
34
What Are the Risk Factors for External Root Resorption of Second Molars Associated With Impacted Third Molars? A Cone-Beam Computed Tomography Study. ( 30265857 )
2018
35
Comparison of the Demirjian and Root Resorption Methods to Estimate Dental Age in Radiographic Images. ( 30345953 )
2018
36
Root resorption of maxillary incisors after traction of unilateral vs bilateral impacted canines with reinforced anchorage. ( 30384935 )
2018
37
Sodium percarbonate as a novel intracoronal bleaching agent: assessment of the associated risk of cervical root resorption. ( 30388301 )
2018
38
Clinical Management of Root Resorption: A Report of Three Cases. ( 30405991 )
2018
39
Dynamic Evaluation of Orthodontically-Induced Tooth Movement, Root Resorption, and Alveolar Bone Remodeling in Rats by in Vivo Micro-Computed Tomography. ( 30448850 )
2018
40
Association between genetic polymorphisms and external apical root resorption: A systematic review and meta-analysis. ( 30450332 )
2018
41
Is Short Root Anomaly (SRA) a risk factor for increased external apical root resorption in orthodontic patients? A retrospective case control study using cone beam computerized tomography. ( 30451366 )
2018
42
Orthodontic - Surgical management in a Class II case with idiopathic root resorption. ( 30453104 )
2018
43
Contact of the incisive canal and upper central incisors causing root resorption after retraction with orthodontic mini-implants: A CBCT study. ( 30484326 )
2018
44
Maxillary Central Incisor Root Resorption due to Canine Impaction after Trauma. Is the Canine Substitution for Maxillary Incisors a suitable Treatment Option? Two Case Reports. ( 30531165 )
2018
45
Prevalence and risk factors of root resorption of adjacent teeth in maxillary canine impaction, among untreated children and adolescents. ( 30535143 )
2018
46
Effect of brightness and contrast variation for detectability of root resorption lesions in digital intraoral radiographs. ( 30535816 )
2018
47
Regenerative endodontic treatment of perforated internal root resorption: a case report. ( 28439906 )
2018
48
Evaluating the Amount of Tooth Movement and Root Resorption during Canine Retraction with Friction versus Frictionless Mechanics Using Cone Beam Computed Tomography. ( 29531610 )
2018
49
External apical root resorption diagnosis by using FII human dentine fraction and salivary IGg. ( 29628427 )
2018
50
Effect of root canal obturation with calcium silicate materials on pH change in simulated root resorption defects. ( 29714703 )
2018

Variations for Root Resorption

Expression for Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for Root Resorption

Pathways related to Root Resorption according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CTSK IL1A IL1B IL1RN P2RX7 TNFRSF11A
2
Show member pathways
13.11 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.45 IL1B TNFRSF11A TNFRSF11B TNFSF11
4 12.35 IL1B IL1RN TNFRSF11A TNFSF11
5
Show member pathways
12.3 IL1A IL1B TNFRSF11A TNFRSF11B TNFSF11
6
Show member pathways
12.25 IL1B IL1RN TNFRSF11A TNFSF11
7
Show member pathways
12.18 CTSK TNFRSF11A TNFRSF11B TNFSF11
8
Show member pathways
12.1 IL1A IL1B IL1RN
9
Show member pathways
12 IL1A IL1B IL1RN
10 11.96 IL1A IL1B IL1RN
11 11.74 CTSK IL1A IL1B TNFRSF11A TNFRSF11B TNFSF11
12 11.66 IL1B TNFRSF11A TNFSF11
13 11.61 CTSK IL1A IL1B TNFRSF11A TNFSF11
14 11.41 CALCA IL1B SPP1
15 11.27 IL1A IL1B IL1RN
16 11.17 IL1A IL1B
17 11.17 IL1A IL1B
18 11.09 RUNX2 SPP1 TNFSF11
19 11.08 TNFRSF11B TNFSF11
20 11.06 IL1A IL1B
21 10.99 IL1A IL1B TNFSF11
22 10.88 CALCA IL1A IL1B RUNX2 SPP1 TNFRSF11A
23 10.82 IL1A IL1B SPP1 TNFSF11
24 10.69 TNFRSF11B TNFSF11
25 10.56 CTSK SPP1 TNFRSF11A TNFRSF11B TNFSF11
26 10.3 IL1A IL1B

GO Terms for Root Resorption

Cellular components related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CALCA CTSK IL1A IL1B IL1RN SPP1
2 vesicle GO:0031982 9.33 IL1B IL1RN SPP1
3 extracellular region GO:0005576 9.28 CALCA CTSK DSPP IL1A IL1B IL1RN

Biological processes related to Root Resorption according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.97 IL1A IL1B IL1RN TNFSF11
2 response to drug GO:0042493 9.92 IL1B IL1RN P2RX7 TNFRSF11B
3 cytokine-mediated signaling pathway GO:0019221 9.91 IL1A IL1B IL1RN TNFSF11
4 positive regulation of gene expression GO:0010628 9.89 IL1A IL1B P2RX7 RUNX2 TNFSF11
5 extracellular matrix organization GO:0030198 9.87 DSPP SPP1 TNFRSF11B
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.85 IL1B IL1RN TNFSF11
7 response to lipopolysaccharide GO:0032496 9.84 IL1B P2RX7 TNFRSF11A
8 skeletal system development GO:0001501 9.83 DSPP RUNX2 TNFRSF11B
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL1B TNFRSF11A TNFSF11
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.81 IL1B TNFRSF11A TNFSF11
11 positive regulation of JNK cascade GO:0046330 9.79 IL1B IL1RN TNFSF11
12 tumor necrosis factor-mediated signaling pathway GO:0033209 9.75 TNFRSF11A TNFRSF11B TNFSF11
13 positive regulation of interleukin-6 production GO:0032755 9.74 IL1B IL1RN P2RX7
14 interleukin-1-mediated signaling pathway GO:0070498 9.73 IL1A IL1B IL1RN
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.7 IL1A IL1B
16 monocyte chemotaxis GO:0002548 9.7 CALCA TNFRSF11A TNFSF11
17 response to interleukin-1 GO:0070555 9.69 IL1RN TNFRSF11A
18 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.69 IL1A IL1B
19 embryo implantation GO:0007566 9.69 CALCA IL1B SPP1
20 osteoclast differentiation GO:0030316 9.68 TNFRSF11A TNFSF11
21 positive regulation of cytokine secretion GO:0050715 9.68 IL1A P2RX7
22 positive regulation of interleukin-8 production GO:0032757 9.68 CALCA IL1B
23 positive regulation of mitotic nuclear division GO:0045840 9.68 IL1A IL1B
24 positive regulation of vascular endothelial growth factor production GO:0010575 9.67 IL1A IL1B
25 bone resorption GO:0045453 9.66 CTSK TNFSF11
26 response to vitamin D GO:0033280 9.65 IL1B SPP1
27 response to ATP GO:0033198 9.64 IL1B P2RX7
28 mammary gland alveolus development GO:0060749 9.64 TNFRSF11A TNFSF11
29 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.63 IL1A IL1B
30 response to carbohydrate GO:0009743 9.62 DSPP IL1B
31 ossification GO:0001503 9.62 DSPP RUNX2 TNFRSF11A TNFSF11
32 positive regulation of JUN kinase activity GO:0043507 9.61 IL1B IL1RN TNFRSF11A
33 ectopic germ cell programmed cell death GO:0035234 9.6 IL1A IL1B
34 negative regulation of glutamate secretion GO:0014050 9.59 IL1B IL1RN
35 positive regulation of prostaglandin secretion GO:0032308 9.58 IL1B P2RX7
36 chronic inflammatory response to antigenic stimulus GO:0002439 9.55 IL1B IL1RN
37 TNFSF11-mediated signaling pathway GO:0071847 9.54 TNFRSF11A TNFSF11
38 fever generation GO:0001660 9.48 IL1A IL1B
39 positive regulation of estradiol secretion GO:2000866 9.46 IL1B SPP1
40 positive regulation of bone resorption GO:0045780 9.43 SPP1 TNFRSF11A TNFSF11
41 inflammatory response GO:0006954 9.43 CALCA IL1A IL1B IL1RN P2RX7 SPP1
42 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.4 TNFRSF11A TNFSF11
43 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.37 TNFRSF11A TNFSF11
44 negative regulation of bone resorption GO:0045779 9.33 CALCA P2RX7 TNFRSF11B
45 regulation of signaling receptor activity GO:0010469 9.17 CALCA IL1A IL1B IL1RN SPP1 TNFRSF11B

Molecular functions related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.93 CALCA CTSK DSPP IL1A IL1B IL1RN
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
3 cytokine activity GO:0005125 9.1 IL1A IL1B IL1RN SPP1 TNFRSF11B TNFSF11

Sources for Root Resorption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
49 NCI
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54 NINDS
55 Novoseek
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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