MCID: RTR008
MIFTS: 44

Root Resorption

Categories: Oral diseases

Aliases & Classifications for Root Resorption

MalaCards integrated aliases for Root Resorption:

Name: Root Resorption 12 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:14550
MeSH 44 D012391
UMLS 70 C0035851

Summaries for Root Resorption

MalaCards based summary : Root Resorption is related to ankylosis and tooth resorption. An important gene associated with Root Resorption is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Simvastatin and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and bone marrow, and related phenotypes are hematopoietic system and growth/size/body region

Related Diseases for Root Resorption

Diseases related to Root Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 ankylosis 31.3 TNFSF11 TNFRSF11B RUNX2
2 tooth resorption 31.0 TNFSF11 TNFRSF11A SPP1 RUNX2 IL1B DSPP
3 chronic apical periodontitis 30.7 TNFSF11 TNFRSF11B IL1B
4 pulpitis 30.6 IL6 IL1B IL1A DSPP
5 dental pulp necrosis 30.6 TNFSF11 IL1B DSPP DMP1
6 periodontitis, chronic 30.5 TNFSF11 TNFRSF11B IL6 IL1B
7 familial expansile osteolysis 30.3 TNFSF11 TNFRSF11B TNFRSF11A SPP1
8 gingival recession 30.3 TNFSF11 IL6 IL1B DSPP
9 cleidocranial dysplasia 30.3 TNFSF11 SPP1 RUNX2
10 suppurative periapical periodontitis 30.1 IL6 IL1B DSPP
11 dental caries 30.1 SPP1 DSPP DMP1
12 sclerosteosis 30.1 TNFSF11 RUNX2 CTSK
13 mammary paget's disease 30.1 TNFSF11 TNFRSF11B TNFRSF11A CALCA
14 osteonecrosis 30.0 TNFSF11 TNFRSF11B RUNX2 IL1B
15 bone resorption disease 30.0 TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2 IL6
16 bacterial infectious disease 29.9 IL6 IL1RN IL1B IL1A
17 dermatitis 29.7 IL6 IL4 IL1B IL1A
18 lichen planus 29.6 IL6 IL4 IL1B
19 calcinosis 29.6 SPP1 SPARC DMP1 CALCA
20 dermatitis, atopic 29.6 IL6 IL4 IL1B IL1A
21 periodontitis 29.2 TNFSF11 RUNX2 MMP9 IL6 IL4 IL1RN
22 gingivitis 29.2 MMP9 IL6 IL4 IL1B IL1A
23 amelogenesis imperfecta 29.1 TNFSF11 RUNX2 MMP9 IL6 IL1B DSPP
24 proteasome-associated autoinflammatory syndrome 1 28.8 MMP9 IL6 IL4 IL1RN IL1B IL1A
25 bone inflammation disease 28.6 TNFSF11 MMP9 IL6 IL4 IL1RN IL1B
26 asthma 28.5 MMP9 IL6 IL4 IL1RN IL1B IL1A
27 type 2 diabetes mellitus 28.1 TNFSF11 TNFRSF11B SPP1 RUNX2 MMP9 IL6
28 tooth ankylosis 11.2
29 permanent molars, secondary retention of 11.2
30 singleton-merten syndrome 1 11.1
31 singleton-merten syndrome 11.1
32 hair whorl 10.7
33 triiodothyronine receptor auxiliary protein 10.7
34 vulvar vestibulitis syndrome 10.4 IL1RN IL1B
35 malignant ovarian brenner tumor 10.4 TNFSF11 CALCA
36 kummell's disease 10.4 TNFSF11 CALCA
37 multicentric reticulohistiocytosis 10.4 TNFSF11 TNFRSF11B
38 physiological polycythemia 10.4 IL6 IL1B
39 polyarticular onset juvenile idiopathic arthritis 10.3 TNFSF11 TNFRSF11B TNFRSF11A
40 hemophilic arthropathy 10.3 TNFSF11 TNFRSF11B TNFRSF11A
41 disseminated chorioretinitis 10.3 TNFSF11 TNFRSF11B TNFRSF11A
42 arachnoiditis 10.3 IL1B IL1A
43 uremic pruritus 10.3 IL6 IL1B
44 periostitis 10.3 TNFRSF11B TNFRSF11A IL1RN
45 meningococcemia 10.3 IL1RN IL1B IL1A
46 teeth, supernumerary 10.3 RUNX2 DSPP
47 aneurysmal bone cysts 10.3 TNFSF11 TNFRSF11A CALCA
48 cryopyrin-associated periodic syndrome 10.3 IL6 IL1RN
49 anaerobic pneumonia 10.3 IL6 IL1B
50 calcific tendinitis 10.3 SPP1 CTSK

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to Root Resorption

Symptoms & Phenotypes for Root Resorption

MGI Mouse Phenotypes related to Root Resorption:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.38 CTSK DMP1 IL1A IL1B IL1RN IL4
2 growth/size/body region MP:0005378 10.37 CTSK DMP1 IL1B IL1RN IL4 IL6
3 homeostasis/metabolism MP:0005376 10.33 CTSK DMP1 IL1A IL1B IL1RN IL4
4 cellular MP:0005384 10.31 CTSK DMP1 IL1RN IL4 IL6 JAG1
5 immune system MP:0005387 10.31 CTSK DMP1 IL1A IL1B IL1RN IL4
6 cardiovascular system MP:0005385 10.29 DMP1 IL1A IL1B IL1RN IL6 JAG1
7 craniofacial MP:0005382 10.26 CTSK DMP1 IL1B IL4 JAG1 RUNX2
8 integument MP:0010771 10.22 IL1A IL1B IL1RN IL4 IL6 JAG1
9 digestive/alimentary MP:0005381 10.05 CTSK IL4 IL6 JAG1 MMP9 RUNX2
10 limbs/digits/tail MP:0005371 10.02 CTSK DMP1 MMP9 P2RX7 RUNX2 SPARC
11 neoplasm MP:0002006 9.92 IL1A IL1B IL6 MMP9 SPARC SPP1
12 reproductive system MP:0005389 9.91 CTSK IL1RN IL4 IL6 MMP9 RUNX2
13 skeleton MP:0005390 9.83 CTSK DMP1 IL1B IL1RN IL4 IL6
14 respiratory system MP:0005388 9.76 CTSK IL4 IL6 MMP9 RUNX2 SPP1
15 vision/eye MP:0005391 9.32 IL4 IL6 JAG1 MMP9 P2RX7 RUNX2

Drugs & Therapeutics for Root Resorption

Drugs for Root Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Simvastatin Approved 79902-63-9 54454
2
tannic acid Approved 1401-55-4
3
Molybdenum Approved 7439-98-7 185498
4
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
5
Ethanol Approved Early Phase 1 64-17-5 702
6
Eugenol Approved Early Phase 1 97-53-0 3314
7
Clotrimazole Approved, Vet_approved Early Phase 1 23593-75-1 2812
8
Zinc Approved, Investigational Early Phase 1 7440-66-6 32051
9
Miconazole Approved, Investigational, Vet_approved Early Phase 1 22916-47-8 4189
10
Zinc oxide Approved Early Phase 1 1314-13-2
11 Anesthetics
12 Anesthetics, Local
13 Antibiotics, Antitubercular
14 Anticholesteremic Agents
15 Hydroxymethylglutaryl-CoA Reductase Inhibitors
16 Antimetabolites
17 Lipid Regulating Agents
18 Hypolipidemic Agents
19 Pharmaceutical Solutions Early Phase 1
20 Anti-Bacterial Agents Early Phase 1
21 Anti-Infective Agents, Local Early Phase 1
22 Antiviral Agents Early Phase 1
23 Anti-Infective Agents Early Phase 1
24 Antifungal Agents Early Phase 1

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound in Human Subjects Unknown status NCT00423956 Phase 1, Phase 2
2 Histological Changes of The Dentinal-Pulp Complex and Root Resorption in Maxillary Premolars With Intrusive Orthodontic Movements Under a Low Power Laser Effect Completed NCT01642693 Phase 1, Phase 2
3 Correlation Between Root Resorption and Dentin Sialoprotein Upon Application of Different Orthodontic Forces, a Split-mouth Technique, a Randomized Clinical Trial Unknown status NCT03644537
4 A Randomized Clinical Trial to Evaluate Labial Alveolar Bone Thickness and Apical Root Resorption Between Two Kinds of Brackets Using CBCT Unknown status NCT02816489
5 Clinical Observation for the Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206
6 A Comparative Clinical and Radiographic Study of 3Mixstatin vs Tri-Antibiotic Mix and Simvastatin in the Treatment of Primary Molars With Inflammatory Root Resorption A Randomized Clinical Trial Unknown status NCT03585751
7 Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technique: A Clinical Study With Cone Beam Computed Tomography Evaluation Completed NCT04410679
8 Curve of Spee: Speed of Leveling Using Different Orthodontic Archwire Size and Material - A Randomized Clinical Trial Completed NCT04549948
9 A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets Completed NCT03613285
10 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Completed NCT02822040
11 Detection of Orthodontically Induced Inflammatory Root Resorption From Gingival Crevicular Fluid by Proteomics Analysis: Split Mouth, Randomized Clinical Trial Completed NCT04291443
12 The Effect of Two Different Types of Forces on Possible Root Resorption in Relation to Dentin Phosphoprotein Levels: A Randomized Controlled Clinical Trial Completed NCT04825665
13 The Effect of Twelve Weeks of Mechanical Vibration on Root Resorption: A Micro-Ct Study Completed NCT04686617
14 Comparison of Root Resorption, Microbial Colonization & Gingival Health Between Clear Aligners, Self-Ligating Brackets & Conventional Brackets- A Randomized Controlled Clinical Trial Completed NCT02745626
15 Placebo-Controlled, Randomized, Double Blind Trial of Effect of Photobiomodulation Therapies On The Root Resorption Associated With Orthodontic Forces: A Pilot Study Using Micro Computed Tomography Completed NCT04044989
16 Use of Biomarkers in Early Surgery Patients to Determine Effectiveness of Regional Acceleratory Phenomenon and Its Effect on Root Resorption Completed NCT04823325
17 Evaluation of Corticision-Based Acceleration of Lower Anterior Teeth Alignment on Root Resorption and Dehiscence Formation Using CBCT Completed NCT04601662
18 Three-dimensional Volumetric/ Linear Analysis and Axial Classification of Root Resorptions Using Cone Beam Computed Tomography: A Retrospective Study Completed NCT04617301
19 Frequency of External Root Resorption and Distal Caries in Mandibular Second Molars Associated With Mandibular Impacted Third Molars in a Sample of Egyptian Population Using CBCT: A Hospital-Based Cross-Sectional Study Not yet recruiting NCT03981367
20 A Comparison Between the Uses of 70% Ethanol With Saline as a Root Canal Irrigation Solution in Pulpectomy With Zinc Oxide Eugenol in Primary Molars: a Randomized Controlled Trial. Not yet recruiting NCT04669392 Early Phase 1 70% Ethanol

Search NIH Clinical Center for Root Resorption

Cochrane evidence based reviews: root resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

MalaCards organs/tissues related to Root Resorption:

40
Bone, Thyroid, Bone Marrow, Cortex, Smooth Muscle, Monocytes, Endothelial

Publications for Root Resorption

Articles related to Root Resorption:

(show top 50) (show all 3490)
# Title Authors PMID Year
1
Rehearsal's effect on recall and comprehension of orthodontic informed consent. 61
33573895 2021
2
Orthodontic Tooth Movement Studied by Finite Element Analysis: an Update. What Can We Learn from These Simulations? 61
33538966 2021
3
Effects of different splinting times on surgically extruded teeth with a crown-root fracture: A randomized controlled trial. 61
33179388 2021
4
Notch signaling inhibition protects against root resorption in experimental immature tooth movement in rats. 61
33568273 2021
5
Traumatic dental injuries and pulp sequelae in an adolescent population. 61
33220150 2021
6
Risk factors for maxillary impacted canine-linked severe lateral incisor root resorption. 61
33795087 2021
7
Autotransplantation of a completely developed impacted maxillary canine: A 7-year follow-up case report. 61
33810831 2021
8
Effectiveness of the Socket Shield Technique in Dental Implant: A Systematic Review. 61
33692284 2021
9
Success, Survival Rate, and Soft Tissue Esthetic of Tooth Autotransplantation. 61
33245974 2021
10
[Surgical uprighting of partially impacted second molars]. 61
33734222 2021
11
Effect of root surface treatment with denusomab after delayed tooth replantation. 61
32728940 2021
12
Effect of micro-osteoperforations on external apical root resorption: A randomized controlled trial. 61
33678624 2021
13
A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption. 61
33804739 2021
14
Effects of different wavelengths of low-level laser therapy on orthodontically induced inflammatory root resorption in rats investigated with micro-computerized tomography. 61
33518440 2021
15
Pathophysiological mechanisms of root resorption after dental trauma: a systematic scoping review. 61
33771147 2021
16
Incisive canal remodelling following maximum anterior retraction reduces apical root resorption. 61
33369873 2021
17
The role of EphB4/ephrinB2 signaling in root repair after orthodontically-induced root resorption. 61
33487501 2021
18
Orthodontically induced root resorption: A critical analysis of finite element studies' input and output. 61
33785230 2021
19
Mid-Term Outcomes And Periodontal Prognostic Factors Of Autotransplanted Third Molars: A Retrospective Cohort Study. 61
33764523 2021
20
The impact of platelet-rich fibrin (PRF) on delayed tooth replantation: A preliminary animal study. 61
33650725 2021
21
Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial. 61
33653326 2021
22
An Orthodontic Approach for Garre's Sclerosing Osteomyelitis of the Mandible. 61
33803857 2021
23
Prevalence of Lateral Radiolucency, Apical Root Resorption and Periapical Lesions in Portuguese Patients: A CBCT Cross-Sectional Study with a Worldwide Overview. 61
33762535 2021
24
Effects of maxillary incisor inclination on dentoalveolar changes in class II division 1 and 2 non-extraction treatment for Caucasian children - A retrospective study using CBCT. 61
33309514 2021
25
The miR-155-5p inhibits osteoclast differentiation through targeting CXCR2 in orthodontic root resorption. 61
33760254 2021
26
Allergies/asthma and root resorption: a systematic review. 61
33718992 2021
27
Intermittent parathyroid hormone promotes cementogenesis via ephrinB2-EPHB4 forward signaling. 61
32740946 2021
28
Central Odontogenic Fibroma with Giant Cell Granuloma-Like Lesion: A Report of an Additional Case and Review of Literature. 61
32212049 2021
29
Enucleation of Recurrent Central Odontogenic Fibroma and Bone Regeneration of the Osseous Defect with Enamel Matrix Derivative and Bone Allograft. Case Report with 5-Year Follow-up. 61
33773076 2021
30
Cell-Based Therapy for Tooth Replantation Following Avulsion: A Systematic Review. 61
33593127 2021
31
Simplifying the approach of open bite treatment with aligners and selective micro-osteoperforations: An adult case report. 61
33358878 2021
32
Microcracks on the Rat Root Surface Induced by Orthodontic Force, Crack Extension Simulation, and Proteomics Study. 61
33686616 2021
33
Comparison of radiographical characteristics and diagnostic accuracy of intraosseous jaw lesions on panoramic radiographs and CBCT. 61
32941743 2021
34
Comparative evaluation of Stainless-steel wires and brackets coated with nanoparticles of Chitosan or Zinc oxide upon friction: An in vitro study. 61
33610486 2021
35
Complications Following One-Stage Versus Two-Stage Surgical Treatment of Transverse Maxillary Hypoplasia. 61
33757746 2021
36
The effectiveness of surgical adjunctive procedures in the acceleration of orthodontic tooth movement: A systematic review of systematic reviews and meta-analysis. 61
33546565 2021
37
The effect of soy and whole milk as a means to store avulsed teeth: A histometric study. 61
32813934 2021
38
Role of c-Fos in orthodontic tooth movement: an in vivo study using transgenic mice. 61
32803442 2021
39
Ectopic eruption of the first permanent molar: Predictive factors for irreversible outcome. 61
33546831 2021
40
Intranuclear Delivery of Nuclear Factor-Kappa B p65 in a Rat Model of Tooth Replantation. 61
33671455 2021
41
Comparison of Three-Dimensional and Conventional Orthodontic Imaging Modalities for Localization of Impacted Maxillary Canines in Patients With Alveolar Cleft. 61
32783463 2021
42
The variability of electric pulp response thresholds in primary molars: a clinical study. 61
33616886 2021
43
Impact of intraoral non-pharmacological non-surgical adjunctive interventions on orthodontically induced inflammatory root resorption in humans: A systematic review. 61
33567160 2021
44
Influence of different types of rapid maxillary expansion on root resorption: a systematic review. 61
33723935 2021
45
Effect of photobiomodulation on external root resorption during orthodontic tooth movement - a randomized controlled trial. 61
33610485 2021
46
Immunocytochemical characterization of primary teeth pulp stem cells from three stages of resorption in serum-free medium. 61
32955751 2021
47
Management of a partially edentulous patient with idiopathic root resorption by using digital and conventional implant planning technologies. 61
33637326 2021
48
Effects of root-cortex relationship, root shape, and impaction side on treatment duration and root resorption of impacted canines. 61
33604600 2021
49
Is Inflammation a Friend or Foe for Orthodontic Treatment?: Inflammation in Orthodontically Induced Inflammatory Root Resorption and Accelerating Tooth Movement. 61
33673606 2021
50
Automated tooth segmentation as an innovative tool to assess 3D-tooth movement and root resorption in rodents. 61
33531044 2021

Variations for Root Resorption

Expression for Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for Root Resorption

Pathways related to Root Resorption according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 TNFSF11 TNFRSF11B TNFRSF11A P2RX7 MMP9 IL6
2
Show member pathways
13.63 TNFSF11 TNFRSF11B TNFRSF11A IL6 IL4 IL1RN
3
Show member pathways
13.24 TNFSF11 TNFRSF11B TNFRSF11A MMP9 IL6 IL4
4
Show member pathways
12.67 P2RX7 IL6 IL1RN IL1B IL1A
5
Show member pathways
12.65 SPP1 SPARC MMP9 DSPP DMP1 CTSK
6
Show member pathways
12.55 JAG1 IL6 IL4 IL1B IL1A
7
Show member pathways
12.53 TNFSF11 TNFRSF11B TNFRSF11A IL1B IL1A
8 12.51 TNFSF11 TNFRSF11A IL4 IL1RN IL1B
9
Show member pathways
12.43 TNFSF11 TNFRSF11A IL1RN IL1B
10
Show member pathways
12.37 TNFSF11 TNFRSF11B TNFRSF11A CTSK
11
Show member pathways
12.29 MMP9 IL6 IL4 IL1B
12 12.13 IL6 IL1RN IL1B IL1A
13 11.95 TNFSF11 TNFRSF11B TNFRSF11A IL1B IL1A CTSK
14 11.93 MMP9 IL6 IL4 IL1B IL1A
15 11.92 MMP9 JAG1 IL6 IL1B
16 11.89 MMP9 IL6 IL4 IL1B IL1A
17 11.88 TNFSF11 TNFRSF11A IL1B
18 11.88 SPARC IL6 IL1B IL1A
19 11.86 IL6 IL1B IL1A
20 11.84 IL6 IL4 IL1B IL1A
21 11.82 SPP1 SPARC RUNX2 IL6
22
Show member pathways
11.81 IL6 IL4 IL1B
23
Show member pathways
11.76 TNFSF11 TNFRSF11B TNFRSF11A
24 11.72 IL6 IL1B IL1A
25 11.71 RUNX2 IL6 IL1B
26 11.7 TNFSF11 TNFRSF11A IL6 IL1B IL1A CTSK
27 11.64 SPP1 RUNX2 MMP9
28
Show member pathways
11.61 MMP9 IL6 IL1B IL1A
29 11.57 SPARC DSPP DMP1
30 11.49 IL6 IL1B IL1A
31 11.48 SPP1 RUNX2 MMP9
32 11.43 SPP1 MMP9 IL6 IL4 IL1B CALCA
33 11.41 IL6 IL4 IL1RN IL1B IL1A
34 11.38 TNFSF11 SPP1 RUNX2
35 11.31 IL6 IL1B IL1A
36 11.27 IL6 IL4 IL1B
37 11.17 IL6 IL4 IL1B IL1A
38 10.96 TNFSF11 SPP1 IL6 IL4 IL1B IL1A
39 10.93 TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2 IL6
40 10.83 TNFSF11 TNFRSF11B
41 10.75 IL6 IL4 IL1B
42 10.56 TNFSF11 TNFRSF11B TNFRSF11A SPP1 CTSK
43 10.5 IL1B IL1A

GO Terms for Root Resorption

Cellular components related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNFSF11 TNFRSF11B SPP1 SPARC MMP9 IL6
2 extracellular region GO:0005576 9.5 TNFSF11 TNFRSF11B SPP1 SPARC MMP9 JAG1
3 extracellular matrix GO:0031012 9.46 TNFRSF11B MMP9 DSPP DMP1

Biological processes related to Root Resorption according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.04 TNFRSF11A RUNX2 IL6 IL4 IL1B
2 positive regulation of gene expression GO:0010628 9.98 TNFSF11 RUNX2 P2RX7 IL6 IL4 IL1B
3 cellular protein metabolic process GO:0044267 9.93 SPP1 IL6 DMP1 CALCA
4 inflammatory response GO:0006954 9.93 SPP1 IL6 IL1RN IL1B IL1A CALCA
5 immune response GO:0006955 9.91 TNFSF11 IL6 IL4 IL1RN IL1B IL1A
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNFSF11 TNFRSF11A IL6 IL1B
7 skeletal system development GO:0001501 9.87 TNFRSF11B RUNX2 MMP9 DSPP
8 interleukin-1-mediated signaling pathway GO:0070498 9.83 IL1RN IL1B IL1A
9 positive regulation of interleukin-6 production GO:0032755 9.83 IL6 IL1B IL1A
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 TNFSF11 TNFRSF11A IL6 IL1B
11 positive regulation of osteoblast differentiation GO:0045669 9.81 RUNX2 JAG1 IL6
12 response to glucocorticoid GO:0051384 9.8 SPARC IL6 IL1RN
13 extracellular matrix organization GO:0030198 9.8 TNFRSF11B SPP1 SPARC MMP9 DSPP DMP1
14 positive regulation of T cell proliferation GO:0042102 9.79 IL6 IL4 IL1B
15 positive regulation of interleukin-8 production GO:0032757 9.77 IL6 IL1B CALCA
16 biomineral tissue development GO:0031214 9.72 SPP1 DSPP DMP1
17 positive regulation of vascular endothelial growth factor production GO:0010575 9.71 IL6 IL1B IL1A
18 monocyte chemotaxis GO:0002548 9.71 TNFSF11 TNFRSF11A IL6 CALCA
19 cytokine-mediated signaling pathway GO:0019221 9.7 TNFSF11 MMP9 IL6 IL4 IL1RN IL1B
20 positive regulation of neuroinflammatory response GO:0150078 9.65 IL6 IL1B
21 positive regulation of bone resorption GO:0045780 9.65 TNFSF11 TNFRSF11A SPP1
22 regulation of neuroinflammatory response GO:0150077 9.64 MMP9 IL6
23 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.61 IL6 IL1RN
24 vascular endothelial growth factor production GO:0010573 9.61 IL6 IL1B
25 TNFSF11-mediated signaling pathway GO:0071847 9.58 TNFSF11 TNFRSF11A
26 positive regulation of immature T cell proliferation in thymus GO:0033092 9.58 IL1B IL1A
27 fever generation GO:0001660 9.56 IL1B IL1A
28 embryo implantation GO:0007566 9.56 SPP1 MMP9 IL1B CALCA
29 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.51 TNFSF11 TNFRSF11A
30 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.49 TNFSF11 TNFRSF11A
31 negative regulation of bone resorption GO:0045779 9.26 TNFRSF11B P2RX7 IL6 CALCA
32 ossification GO:0001503 9.23 TNFSF11 TNFRSF11A SPP1 SPARC RUNX2 MMP9

Molecular functions related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.43 SPP1 SPARC DMP1
2 interleukin-1 receptor binding GO:0005149 9.33 IL1RN IL1B IL1A
3 collagen binding GO:0005518 9.26 SPARC MMP9 DSPP CTSK
4 cytokine activity GO:0005125 9.23 TNFSF11 TNFRSF11B SPP1 IL6 IL4 IL1RN

Sources for Root Resorption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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