Root Resorption

Categories: Oral diseases

Aliases & Classifications for Root Resorption

MalaCards integrated aliases for Root Resorption:

Name: Root Resorption 12 43 15 71


External Ids:

Disease Ontology 12 DOID:14550
MeSH 43 D012391
UMLS 71 C0035851

Summaries for Root Resorption

MalaCards based summary : Root Resorption is related to ankylosis and tooth resorption. An important gene associated with Root Resorption is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Caseins and Fluorides have been mentioned in the context of this disorder. Affiliated tissues include bone, colon and thyroid, and related phenotypes are hematopoietic system and growth/size/body region

Related Diseases for Root Resorption

Diseases related to Root Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 393)
# Related Disease Score Top Affiliating Genes
1 ankylosis 31.4 TNFSF11 TNFRSF11B RUNX2
2 tooth resorption 31.4 TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2 IL1B
3 dental pulp necrosis 30.6 TNFSF11 DSPP DMP1
4 periodontitis, chronic 30.6 TNFSF11 TNFRSF11B IL6 IL1B
5 pulpitis 30.6 IL6 IL1B IL1A DSPP
6 gingival recession 30.5 IL6 IL1B DSPP
7 familial expansile osteolysis 30.4 TNFSF11 TNFRSF11B TNFRSF11A SPP1
8 endosteal hyperostosis, autosomal dominant 30.3 TNFSF11 TNFRSF11B CTSK
9 suppurative periapical periodontitis 30.2 IL6 IL1B DSPP
10 osteonecrosis 30.1 TNFSF11 TNFRSF11B RUNX2 IL1B
11 idiopathic hypercalciuria 30.1 VDR TNFSF11 IL1B
12 bacterial infectious disease 29.9 IL6 IL1RN IL1B IL1A
13 mammary paget's disease 29.8 TNFSF11 TNFRSF11B TNFRSF11A CTSK CALCA
14 dermatitis 29.5 IL6 IL4 IL1B IL1A
15 calcinosis 29.4 SPP1 SPARC DMP1 CALCA
16 fibrous dysplasia 29.1 TNFSF11 TNFRSF11B TNFRSF11A SPP1 SPARC RUNX2
17 gingivitis 29.0 MMP9 IL6 IL4 IL1B IL1A
18 rickets 28.9 VDR SPP1 DSPP DMP1 CALCA
19 bone resorption disease 28.7 VDR TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2
20 nephrolithiasis 28.6 VDR TNFRSF11B SPP1 MMP9 IL1RN IL1B
21 proteasome-associated autoinflammatory syndrome 1 28.6 MMP9 IL6 IL4 IL1RN IL1B IL1A
22 diabetes mellitus, type i 28.5 VDR IL6 IL4 IL1RN IL1B IFIH1
23 bone inflammation disease 28.1 TNFSF11 TNFRSF11B MMP9 IL6 IL4 IL1RN
24 myeloma, multiple 27.7 TNFSF11 TNFRSF11B SPP1 RUNX2 MMP9 IL6
25 periodontitis 27.7 VDR TNFSF11 TNFRSF11B SPP1 RUNX2 MMP9
26 osteoporosis 24.1 VDR TNFSF11 TNFRSF11B TNFRSF11A SPP1 SPARC
27 tooth ankylosis 11.8
28 permanent molars, secondary retention of 11.4
29 singleton-merten syndrome 1 11.3
30 singleton-merten syndrome 11.3
31 hair whorl 10.7
32 triiodothyronine receptor auxiliary protein 10.6
33 systemic onset juvenile idiopathic arthritis 10.6 IL1RN IL1B
34 malignant ovarian brenner tumor 10.5 TNFSF11 CALCA
35 vulvar vestibulitis syndrome 10.5 IL1RN IL1B
36 acute pericementitis 10.5 TNFSF11 IL1B
37 polyarticular onset juvenile idiopathic arthritis 10.5 TNFSF11 TNFRSF11B TNFRSF11A
38 hemophilic arthropathy 10.4 TNFSF11 TNFRSF11B TNFRSF11A
39 disseminated chorioretinitis 10.4 TNFSF11 TNFRSF11B TNFRSF11A
40 villonodular synovitis 10.4 TNFSF11 MMP9
41 teeth, supernumerary 10.4 RUNX2 DSPP
42 chondrocalcinosis 10.4 TNFRSF11B IL1RN IL1B
43 aneurysmal bone cysts 10.4 TNFSF11 TNFRSF11A CALCA
44 meningococcemia 10.4 IL1RN IL1B IL1A
45 uremic pruritus 10.4 IL6 IL1B
46 bullous impetigo 10.4 IL6 CALCA
47 cryopyrin-associated periodic syndrome 10.4 IL6 IL1RN
48 prosthetic joint infection 10.4 TNFRSF11B IL6 IL1B
49 cinca syndrome 10.4 IL1RN IL1B IL1A
50 cartilage disease 10.3 RUNX2 IL1RN IL1B

Graphical network of the top 20 diseases related to Root Resorption:

Diseases related to Root Resorption

Symptoms & Phenotypes for Root Resorption

MGI Mouse Phenotypes related to Root Resorption:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 CALCR CTSK DMP1 IFIH1 IL1A IL1B
2 growth/size/body region MP:0005378 10.4 CTSK DMP1 IFIH1 IL1B IL1RN IL4
3 homeostasis/metabolism MP:0005376 10.39 CALCR CTSK DMP1 IFIH1 IL1A IL1B
4 immune system MP:0005387 10.39 CALCR CTSK DMP1 IFIH1 IL1A IL1B
5 cellular MP:0005384 10.34 CTSK DMP1 IFIH1 IL1RN IL4 IL6
6 cardiovascular system MP:0005385 10.28 DMP1 IL1A IL1B IL1RN IL6 MMP9
7 craniofacial MP:0005382 10.25 CTSK DMP1 IL1B IL4 RUNX2 SPARC
8 integument MP:0010771 10.25 IFIH1 IL1A IL1B IL1RN IL4 IL6
9 mortality/aging MP:0010768 10.13 CALCR IFIH1 IL1B IL1RN IL4 IL6
10 limbs/digits/tail MP:0005371 10.11 CALCR CTSK DMP1 MMP9 P2RX7 RUNX2
11 reproductive system MP:0005389 9.9 CTSK DMP1 IL1RN IL4 IL6 MMP9
12 neoplasm MP:0002006 9.86 IL1A IL1B IL6 MMP9 SPARC SPP1
13 respiratory system MP:0005388 9.56 CTSK IL4 IL6 MMP9 RUNX2 SPP1
14 skeleton MP:0005390 9.53 CALCR CTSK DMP1 IL1B IL1RN IL4

Drugs & Therapeutics for Root Resorption

Drugs for Root Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Caseins Phase 4
2 Fluorides Phase 4
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 9552079 2713
4 Chlorhexidine gluconate Phase 2
5 Mitogens Phase 1
Simvastatin Approved 79902-63-9 54454
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
Clotrimazole Approved, Vet_approved 23593-75-1 2812
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
Lidocaine Approved, Vet_approved 137-58-6 3676
Epinephrine Approved, Vet_approved 51-43-4 5816
Racepinephrine Approved 329-65-7 838
13 sodium fluoride Approved 7681-49-4
Ketorolac Approved 66635-83-4, 74103-06-3 3826
Diclofenac Approved, Vet_approved 15307-86-5 3033
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
leucovorin Approved 58-05-9 6006 143
Pemetrexed Approved, Investigational 137281-23-3, 150399-23-8 60843 446556
Copper Approved, Investigational 7440-50-8 27099
Hydrocodone Approved, Illicit, Investigational 125-29-1 5284569
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
Acetaminophen Approved 103-90-2 1983
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
24 Garlic Approved, Nutraceutical 8008-99-9
25 Anesthetics, Local
26 Hypolipidemic Agents
27 Lipid Regulating Agents
28 Hydroxymethylglutaryl-CoA Reductase Inhibitors
29 Anticholesteremic Agents
30 Antibiotics, Antitubercular
31 Antimetabolites
32 Sunscreening Agents
33 Radiation-Protective Agents
34 Anti-Infective Agents
35 Anti-Bacterial Agents
36 Antifungal Agents
37 Dermatologic Agents
38 Keratolytic Agents
39 Epinephryl borate
Bismuth 7440-69-9 16682734 105143
41 Anti-Infective Agents, Local
42 Listerine
43 Analgesics, Non-Narcotic
44 Cyclooxygenase Inhibitors
45 Anti-Inflammatory Agents
46 Antirheumatic Agents
47 Anti-Inflammatory Agents, Non-Steroidal
48 Eusol
49 Sodium hypochlorite
50 Anesthetics

Interventional clinical trials:

(show top 50) (show all 79)
# Name Status NCT ID Phase Drugs
1 The Use of MI Varnish for the Prevention and Reduction of White Spot Lesions in Orthodontic Treatment Completed NCT03446690 Phase 4 MI Varnish
2 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound in Human Subjects Unknown status NCT00423956 Phase 1, Phase 2
3 Histological Changes of The Dentinal-Pulp Complex and Root Resorption in Maxillary Premolars With Intrusive Orthodontic Movements Under a Low Power Laser Effect Completed NCT01642693 Phase 1, Phase 2
4 Evaluation of Effectiveness of Chlorhexidine Intracanal Medicament on Periodontal Healing in Concomitant Endodontic and Periodontal Disease With Communication : A Randomized Controlled Clinical Trial Completed NCT02627326 Phase 2
5 Periodontal Tissue Regeneration Using Autologous Periodontal Ligament Stem Cells: Randomized Controlled Clinical Trial Unknown status NCT01357785 Phase 1
6 Efficacy of Platelet-rich Plasma in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
7 Clinical/Numerical Study of the Effects of Periodontal Ligament Stress Level on the Rate Bodily Tooth Movement Completed NCT00099814 Phase 1
8 Clinical Observation for the Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206
9 A Randomized Clinical Trial to Evaluate Labial Alveolar Bone Thickness and Apical Root Resorption Between Two Kinds of Brackets Using CBCT Unknown status NCT02816489
10 A Comparative Clinical and Radiographic Study of 3Mixstatin vs Tri-Antibiotic Mix and Simvastatin in the Treatment of Primary Molars With Inflammatory Root Resorption A Randomized Clinical Trial Unknown status NCT03585751
11 Randomized Controlled Clinical Study Comparing Conventional and CAD/CAM-Based Treatment With Fixed Orthodontic Appliances Unknown status NCT00871026
12 Periodontally Accelerated Orthodontics - A Novel Technique For a Shortened Orthodontic Treatment With a Stable Result. A Clinical and Computerized Tomography Analysis Unknown status NCT01628575
13 Clinical Applicability of PBS® CIMMO Cement in Decoded Teeth Pulpotomies as Base and Restoration Unknown status NCT03200938
14 Assessment of Root Apex Position of Mandibular Molars and Premolars Linear to Inferior Alveolar Canal Among a Sample of Egyptian Population Using CBCT: A Cross Sectional Study Unknown status NCT03537209
15 Assessment of the Variations in the Number of Roots and the Root Canal System of the Permanent Mandibular First and Second Molars in a Sample of Egyptian Population Using Cone Beam Computed Tomography Unknown status NCT03530865
16 Compare the Clinical/Radiographic Outcomes of Potassium Nitrate in Polycarboxylate Cement and MTA as Pulpotomy Biomaterials Used for Asymptomatic Vital Immature Permanent Lower First Molars Unknown status NCT03166748
17 Treatment of Internal Inflammatory Root Resorption Using Injectable PRF Revascularization Technique: A Clinical Study With Cone Beam Computed Tomography Evaluation Completed NCT04410679
18 A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets Completed NCT03613285
19 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Completed NCT02822040
20 Detection of Orthodontically Induced Inflammatory Root Resorption From Gingival Crevicular Fluid by Proteomics Analysis: Split Mouth, Randomized Clinical Trial Completed NCT04291443
21 A Clinical Comparison of the Effectiveness of Two Types of Orthodontic Aligning Archwire Materials: A Randomized Clinical Trial Completed NCT04090931
22 Placebo-Controlled, Randomized, Double Blind Trial of Effect of Photobiomodulation Therapies On The Root Resorption Associated With Orthodontic Forces: A Pilot Study Using Micro Computed Tomography Completed NCT04044989
23 Evaluation of the Efficiency of Corticision on Accelerating of Leveling and Alignment Lower Crowded Incisors Using Cone Beam Computed Tomography - A Randomized Controlled Trial Completed NCT03310086
24 The Effect of OrthoPulse™ on the Rate of Orthodontic Tooth Movement During Alignment With Fixed Appliances Completed NCT02267811
25 Ectopic Eruption of Permanent First Molars: A Retrospective Study Completed NCT04282772
26 Mandibular Molar Protraction Assisted by Temporary Anchorage Device and Piezoelectric Corticotomy Completed NCT04338789
27 Evaluation of Low-Level Laser Therapy (LLLT) Effectiveness in Accelerating Orthodontic Tooth Movement For Dental Crowding Cases: A Randomized Controlled Clinial Trial Completed NCT02568436
28 Assessment of Piezoelectric Periodontal Surgery Effects on Orthodontic Treatment: a Prospective Pilot Study Completed NCT02359760
29 Efficacy of Micro-osteoperforations on the Rate of Maxillary Canine Retraction: A Randomized Controlled Trial Completed NCT04383600
30 Evaluation of the Efficacy of Laser-assisted Flapless Corticotomy in Accelerating Canine Retraction: A Split-mouth Randomized Controlled Clinical Trial Completed NCT04316403
31 Evaluation of Treatment Outcomes of Corticotomy-accelerated Upper Incisors' Retraction: A Randomized Controlled Trial Completed NCT03149016
32 Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth Completed NCT02740907
33 Evaluation of the Combined Effect of Corticotomy and Low Level Laser Therapy on the Rate of Orthodontic Tooth Movement: Split Mouth Randomized Clinical Trial Completed NCT03906084
34 Comparison of Root Resorption, Microbial Colonization & Gingival Health Between Clear Aligners, Self-Ligating Brackets & Conventional Brackets- A Randomized Controlled Clinical Trial Completed NCT02745626
35 Checking Occlusion During Stainless Steel Crown Placement in Children Under General Anesthesia - Evaluation of a Novel Technique Completed NCT02437565
36 Evaluation of Post-operative Discomforts in Children After Extraction of Temporary Teeth _ DEXTRAFANT _ RC16_0183 Completed NCT03878173
37 Is the 0.018-inch or the 0.022-inch Bracket Slot System More Effective in Orthodontic Treatment? A Randomized Clinical Trial. Completed NCT02080338
38 Evaluation the Efficacy of Rapid and Slow Maxillary Expansion in Posterior Crossbite Treatment Using Cone Beam Computed Tomography Completed NCT03667508
39 Micro-osteoperforations and Tooth Movement: A Randomized Controlled Clinical Trial Completed NCT02473471
40 Effect of Micro-osteoperforation on the Rate of Canine Retraction: A Split Mouth Randomized Controlled Trial Completed NCT03450278
41 The Effect of Pulpotomy (Partial or Complete) Using Resin-Modified Calcium Silicate Versus MTA-Anglus on Survival Rate of Cariously-Exposed Vital Young Permanent Molars:A Randomized Clinical Trial Completed NCT03119779 MTA-Anglus;TheraCal
42 Evaluation of the Levels of Pain and Discomfort Between Piezosurgery-assisted Corticotomy Versus Traditional Method of Aligning Crowded Lower Anterior Teeth: a Randomized Controlled Trial Completed NCT02975765
43 Evaluation of the Efficacy of Flapless Corticotomy Accomplished by Piezosurgery in Accelerating Orthodontic Treatment of Crowding in Adults: a Randomized Controlled Trial Completed NCT02977221
44 Is Biodentine, as Successful as, Mineral Trioxide Aggregate for Pulpotomy of Primary Molars? A Split Mouth Clinical Trial Completed NCT03686475
45 Evaluation the Efficacy of Flapless Corticotomy Accomplished by Either Hard-laser or Piezosurgey in Accelerating Upper Canine Retraction and Evaluation of the Dento-alveolar Changes and the Levels of Acceptance and Discomfort. Completed NCT02606331
46 Comparison of Clinpro™ 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste, Clinpro™ Tooth Crème, and MI-Paste Plus for the Prevention and Reduction of White Spot Lesions in Orthodontic Treatment Completed NCT03440996
47 The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo on Postoperative Pain in Teeth With Irreversible Pulpitis and Apical Periodontitis Completed NCT03116672 one dose ketorolac 10 mg;One dose Diclofenac;Placebo oral capsule
48 Factors Affecting the Pulpal Prognosis of Injured Teeth Completed NCT03845426
49 Success Rate of Three Capping Materials Used in Pulpotomy of Primary Molars: A Randomized Clinical Trial Completed NCT03833557
50 Evaluation of Distal Movement of Maxillary Dentition With Zygomatic Miniplates: a Clinical Study Using Cone Beam Computed Tomography Completed NCT03467555

Search NIH Clinical Center for Root Resorption

Cochrane evidence based reviews: root resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

MalaCards organs/tissues related to Root Resorption:

Bone, Colon, Thyroid, Bone Marrow, Testes, Monocytes, Heart

Publications for Root Resorption

Articles related to Root Resorption:

(show top 50) (show all 3297)
# Title Authors PMID Year
Baicalin inhibits root resorption during tooth movement in a rodent model. 61
32470833 2020
Effects of estrogen on root repair after orthodontically induced root resorption in ovariectomized rats. 61
32507529 2020
Clear Aligner Therapy May Not Prevent But May Decrease the Incidence of External Root Resorption Compared to Full Fixed Appliances. 61
32473807 2020
Effects of mesenchymal stem cell transfer on orthodontically induced root resorption and orthodontic tooth movement during orthodontic arch expansion protocols: an experimental study in rats. 61
31143928 2020
Influence of anti-allergic drugs used systemically on the process of root resorption during delayed tooth replantation: A study in rats. 61
31845526 2020
The effects of binge alcohol exposure on tooth movement and associated root resorption in rats. 61
32574660 2020
Injectable RANKL sustained release formulations to accelerate orthodontic tooth movement. 61
31147678 2020
Designing a mandibular advancement device with topology optimization for a partially edentulous patient. 61
31590981 2020
A cone-beam computed tomographic assessment of the proximity of the maxillary canine and posterior teeth to the maxillary sinus floor: Lessons from 4778 roots. 61
32487309 2020
Treatment of severely decayed anterior primary teeth with short-post technique (Mushroom Restorations) under general anesthesia. 61
32525114 2020
[Therapeutic effect analysis of skeletal class Ⅲ malocclusion treatment by transmission straight wire technique]. 61
32573139 2020
Strengthening effect of bioceramic cement when used to repair simulated internal resorption cavities in endodontically treated teeth. 61
32559025 2020
Influence of adjacent teeth restored with metal posts in the detection of simulated internal root resorptions using CBCT. 61
32535964 2020
Effect of Orthodontic Treatment on Tooth Autotransplantation: Systematic Review of Controlled Clinical Trials. 61
32542634 2020
Implant and Prosthetic Treatment in Esthetic Zone with Alveolar Ridge Preservation and Autotransplantation: Clinical Case Report with 16-year Follow-up. 61
32507781 2020
Anti-inflammatory and anti-resorptive efficacy of adrenergic blockers on late replanted rat incisors. 61
31647601 2020
Effects of photobiomodulation at different wavelengths on orthodontically induced root resorption in orthodontic retention period: a micro-CT and RT-PCR study. 61
32399713 2020
Risk factors for external root resorption of maxillary second molars due to impacted third molars as evaluated using cone beam computed tomography. 61
31676229 2020
Unilateral maxillary central incisor root resorption after orthodontic treatment for Angle Class II, division 1 malocclusion with significant maxillary midline deviation: A possible correlation with root proximity to the incisive canal. 61
32475849 2020
Evaluation of Risk Factors for External Root Resorption and Dental Caries of Second Molars Associated With Impacted Third Molars. 61
32504563 2020
Diagnostic efficacy of different cone beam computed tomography scanning protocols in the detection of chemically simulated external root resorption. 61
32423729 2020
Root resorption and ensuing cementum repair by Wnt/β-catenin dependent mechanism. 61
32381434 2020
A case of Invasive Cervical Root Resorption in a 12 y.o. female patient. 61
32323702 2020
Association between root resorption and tooth development: A quantitative clinical study. 61
32354433 2020
Apical root resorption after orthodontic treatment in patients with unilateral cleft lip and palate. 61
31410675 2020
The importance of bioceramics and computed tomography in the late clinical management of a horizontal root fracture: A case report. 61
32509236 2020
Orthodontic treatment recommendation and expected adverse reactions in patients with a history of dental trauma: A survey among general dentists, paediatric dentists, and orthodontic specialists. 61
31803975 2020
Severity and prevalence of root resorption in maxillary canine impaction. 61
32448562 2020
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. 61
32368796 2020
Biomechanical influence of anchorages on orthodontic space closing mechanics by sliding method. 61
32162244 2020
Survival of avulsed permanent incisors in children following delayed replantation. 61
32367869 2020
Comparison of dental outcomes in patients with nonsyndromic complete unilateral cleft lip and palate who receive secondary alveolar bone grafting before or after emergence of the permanent maxillary canine. 61
32354440 2020
Early Jurassic dinosaur fetal dental development and its significance for the evolution of sauropod dentition. 61
32382025 2020
Comparative analysis of panoramic radiography and cone-beam computed tomography in treatment planning of palatally displaced canines. 61
32354444 2020
NLRP3 inflammasome mediates M1 macrophage polarization and IL-1β production in inflammatory root resorption. 61
31976565 2020
Development of a clinical practice guideline for orthodontically induced external apical root resorption. 61
31087032 2020
Small case series suggests positive outcomes of vital pulp therapy for treating invasive cervical root resorption. 61
32005443 2020
Effect of photobiomodulation therapies on the root resorption associated with orthodontic forces: a pilot study using micro computed tomography. 61
31773372 2020
Effect of interleukin-33 on cementoblast-mediated cementum repair during orthodontic tooth movement. 61
31986333 2020
Clinical outcomes of 79 traumatically intruded permanent teeth in Chinese children and adolescents: A retrospective study. 61
31638331 2020
Epidemiological, clinical, and 3-dimentional CBCT radiographic characterizations of supernumerary teeth in a non-syndromic adult population: a single-institutional study from 60,104 Chinese subjects. 61
32333176 2020
Effect of micro-osteoperforation on the rate of orthodontic tooth movement-a systematic review and a meta-analysis. 61
31215993 2020
A bibliometric analysis of the top 50 most cited articles published in the Dental Traumatology. 61
31800153 2020
Delayed diagnosis of displaced and impacted canines - a prospective longitudinal study. 61
31556769 2020
Effect of Low Intensity Pulsed Ultrasound (LIPUS) on Tooth Movement and Root Resorption: A Prospective Multi-Center Randomized Controlled Trial. 61
32188053 2020
Evaluation of Root Resorption, Tooth Inclination and Changes in Supporting Bone in Class II Malocclusion Patients Treated with Forsus Appliance. 61
32284895 2020
Effects of five levels of noise reduction applied to indirect digital radiography on diagnostic accuracy of external apical root resorption. 61
32435435 2020
Effectiveness of five instruments when removing calcium hydroxide paste from simulated internal root resorption cavities in extracted maxillary central incisors. 61
31566756 2020
Bond strength of cemented fiber posts to teeth with simulated internal root resorption. 61
32190199 2020
Incidence of root resorption after concussion, subluxation, lateral luxation, intrusion, and extrusion: a systematic review. 61
31953685 2020

Variations for Root Resorption

Expression for Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for Root Resorption

Pathways related to Root Resorption according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.69 P2RX7 IL6 IL1RN IL1B IL1A
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.3 MMP9 IL6 IL4 IL1B
10 12.2 VDR IL6 IL1B IL1A
11 12.14 IL6 IL1RN IL1B IL1A
12 11.95 MMP9 IL6 IL4 IL1B IL1A
13 11.9 SPARC IL6 IL1B IL1A
14 11.89 MMP9 IL6 IL4 IL1B IL1A
15 11.86 IL6 IL4 IL1B IL1A
16 11.84 SPP1 SPARC RUNX2 IL6
Show member pathways
11.81 IL6 IL4 IL1B
Show member pathways
21 11.73 IL6 IL1B IL1A
22 11.71 RUNX2 IL6 IL1B
23 11.65 SPP1 RUNX2 MMP9
Show member pathways
11.62 MMP9 IL6 IL1B IL1A
25 11.58 SPARC DSPP DMP1
26 11.53 SPP1 MMP9 IL6 IL4 IL1B CALCA
27 11.49 IL6 IL1B IL1A
28 11.48 SPP1 RUNX2 MMP9
29 11.46 IL6 IL4 IL1RN IL1B IL1A
30 11.35 VDR TNFSF11 SPP1 RUNX2
31 11.33 IL6 IL1B IL1A
32 11.32 IL6 IL1B IL1A
33 11.27 IL6 IL4 IL1B
34 11.17 IL6 IL4 IL1B IL1A
36 10.99 TNFSF11 SPP1 IL6 IL4 IL1B IL1A
37 10.75 IL6 IL4 IL1B
39 10.5 IL1B IL1A

GO Terms for Root Resorption

Cellular components related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNFSF11 TNFRSF11B SPP1 SPARC MMP9 IL6
2 vesicle GO:0031982 9.56 SPP1 SPARC IL1RN IL1B
3 extracellular matrix GO:0031012 9.55 TNFRSF11B SPARC MMP9 DSPP DMP1
4 extracellular region GO:0005576 9.47 TNFSF11 TNFRSF11B SPP1 SPARC MMP9 IL6

Biological processes related to Root Resorption according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 VDR TNFRSF11B TNFRSF11A SPP1 IL6 IL4
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.21 VDR TNFSF11 RUNX2 IL6 IL4 IL1B
3 immune response GO:0006955 10 TNFSF11 IL6 IL4 IL1RN IL1B IL1A
4 cellular protein metabolic process GO:0044267 9.97 SPP1 IL6 DMP1 CALCA
5 cellular response to lipopolysaccharide GO:0071222 9.94 VDR IL6 IL1B IL1A
6 response to lipopolysaccharide GO:0032496 9.93 TNFRSF11A SPARC P2RX7 IL1B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 TNFSF11 TNFRSF11A IL6 IL1B
8 skeletal system development GO:0001501 9.88 VDR TNFRSF11B RUNX2 MMP9 DSPP
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.87 TNFSF11 TNFRSF11A IL6 IL1B
10 inflammatory response GO:0006954 9.87 SPP1 P2RX7 IL6 IL1RN IL1B IL1A
11 extracellular matrix organization GO:0030198 9.85 TNFRSF11B SPP1 SPARC MMP9 DSPP DMP1
12 positive regulation of T cell proliferation GO:0042102 9.84 IL6 IL4 IL1B
13 positive regulation of interleukin-6 production GO:0032755 9.82 P2RX7 IL6 IL1B
14 response to glucocorticoid GO:0051384 9.8 SPARC IL6 IL1RN CALCR
15 cytokine-mediated signaling pathway GO:0019221 9.8 TNFSF11 MMP9 IL6 IL4 IL1RN IL1B
16 positive regulation of interleukin-6 secretion GO:2000778 9.79 IL1B IL1A IFIH1
17 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.77 IL4 IL1B IL1A
18 biomineral tissue development GO:0031214 9.77 SPP1 DSPP DMP1
19 osteoclast differentiation GO:0030316 9.75 TNFSF11 TNFRSF11A CALCR
20 positive regulation of vascular endothelial growth factor production GO:0010575 9.73 IL6 IL1B IL1A
21 monocyte chemotaxis GO:0002548 9.73 TNFSF11 TNFRSF11A IL6 CALCA
22 embryo implantation GO:0007566 9.71 SPP1 MMP9 IL1B CALCA
23 inflammatory response to antigenic stimulus GO:0002437 9.7 IL1RN IL1B IL1A
24 positive regulation of bone resorption GO:0045780 9.69 TNFSF11 TNFRSF11A SPP1
25 positive regulation of chemokine biosynthetic process GO:0045080 9.68 IL4 IL1B
26 positive regulation of neuroinflammatory response GO:0150078 9.68 IL6 IL1B
27 regulation of neuroinflammatory response GO:0150077 9.67 MMP9 IL6
28 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.66 IL6 IL1RN
29 amylin receptor signaling pathway GO:0097647 9.65 CALCR CALCA
30 ectopic germ cell programmed cell death GO:0035234 9.65 IL1B IL1A
31 positive regulation of prostaglandin secretion GO:0032308 9.65 P2RX7 IL1B
32 TNFSF11-mediated signaling pathway GO:0071847 9.61 TNFSF11 TNFRSF11A
33 positive regulation of immature T cell proliferation in thymus GO:0033092 9.61 IL1B IL1A
34 positive regulation of gene expression GO:0010628 9.61 VDR TNFSF11 RUNX2 P2RX7 IL6 IL4
35 fever generation GO:0001660 9.58 IL1B IL1A
36 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.55 TNFSF11 TNFRSF11A
37 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.54 TNFSF11 TNFRSF11A
38 negative regulation of bone resorption GO:0045779 9.46 TNFRSF11B P2RX7 IL6 CALCA
39 ossification GO:0001503 9.17 TNFSF11 TNFRSF11A SPP1 SPARC RUNX2 DSPP

Molecular functions related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 VDR TNFSF11 TNFRSF11B TNFRSF11A SPP1 SPARC
2 signaling receptor activity GO:0038023 9.67 VDR TNFRSF11B TNFRSF11A P2RX7
3 collagen binding GO:0005518 9.46 SPARC MMP9 DSPP CTSK
4 extracellular matrix binding GO:0050840 9.43 SPP1 SPARC DMP1
5 cytokine activity GO:0005125 9.23 TNFSF11 TNFRSF11B SPP1 IL6 IL4 IL1RN
6 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Root Resorption

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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