Root Resorption

Categories: Oral diseases

Aliases & Classifications for Root Resorption

MalaCards integrated aliases for Root Resorption:

Name: Root Resorption 12 43 15 71


External Ids:

Disease Ontology 12 DOID:14550
MeSH 43 D012391
UMLS 71 C0035851

Summaries for Root Resorption

MalaCards based summary : Root Resorption is related to tooth resorption and chronic apical periodontitis. An important gene associated with Root Resorption is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Calcium and Calcium, Dietary have been mentioned in the context of this disorder. Affiliated tissues include bone, thyroid and heart, and related phenotypes are hematopoietic system and growth/size/body region

Related Diseases for Root Resorption

Diseases related to Root Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 tooth resorption 31.6 TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2 DSPP
2 chronic apical periodontitis 30.8 TNFSF11 TNFRSF11B IL1B
3 dental pulp necrosis 30.6 TNFSF11 DSPP DMP1
4 periodontitis, chronic 30.6 TNFSF11 TNFRSF11B IL6 IL1B
5 pulpitis 30.6 IL6 IL1B IL1A DSPP
6 familial expansile osteolysis 30.4 TNFSF11 TNFRSF11B TNFRSF11A
7 endosteal hyperostosis, autosomal dominant 30.3 TNFSF11 TNFRSF11B CTSK
8 osteonecrosis 30.2 TNFSF11 TNFRSF11B RUNX2
9 idiopathic hypercalciuria 30.1 VDR TNFSF11 IL1B
10 bacterial infectious disease 29.9 IL6 IL1RN IL1B IL1A
11 mammary paget's disease 29.8 TNFSF11 TNFRSF11B TNFRSF11A CTSK CALCA
12 nephrolithiasis, calcium oxalate 29.5 VDR SPP1 CALCR CALCA
13 dental caries 29.5 VDR DSPP DMP1
14 calcinosis 29.4 SPP1 SPARC DMP1 CALCA
15 fibrous dysplasia 29.4 SPP1 SPARC RUNX2 IL6 CALCA
16 rickets 29.2 VDR SPP1 DSPP DMP1
17 gingivitis 29.0 MMP9 IL6 IL4 IL1B IL1A
18 bone resorption disease 28.9 VDR TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2
19 proteasome-associated autoinflammatory syndrome 1 28.5 MMP9 IL6 IL4 IL1RN IL1B IL1A
20 bone inflammation disease 28.4 TNFSF11 TNFRSF11B MMP9 IL6 IL4 IL1RN
21 myeloma, multiple 27.9 TNFSF11 TNFRSF11B SPP1 RUNX2 MMP9 IL6
22 periodontitis 27.3 VDR TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2
23 osteoporosis 24.0 VDR TNFSF11 TNFRSF11B TNFRSF11A SPP1 SPARC
24 tooth ankylosis 11.7
25 permanent molars, secondary retention of 11.4
26 singleton-merten syndrome 1 11.3
27 singleton-merten syndrome 11.3
28 hair whorl 10.7
29 ankylosis 10.6
30 triiodothyronine receptor auxiliary protein 10.6
31 systemic onset juvenile idiopathic arthritis 10.6 IL1RN IL1B
32 malignant ovarian brenner tumor 10.5 TNFSF11 CALCA
33 vulvar vestibulitis syndrome 10.5 IL1RN IL1B
34 polyarticular onset juvenile idiopathic arthritis 10.5 TNFSF11 TNFRSF11B TNFRSF11A
35 hemophilic arthropathy 10.4 TNFSF11 TNFRSF11B TNFRSF11A
36 teeth, supernumerary 10.4 RUNX2 DSPP
37 multicentric carpotarsal osteolysis syndrome 10.4 TNFSF11 TNFRSF11B TNFRSF11A
38 villonodular synovitis 10.4 TNFSF11 MMP9
39 osteosclerotic myeloma 10.4 IL6 IL1B
40 periostitis 10.4 TNFRSF11B TNFRSF11A IL1RN
41 aneurysmal bone cysts 10.4 TNFSF11 TNFRSF11A CALCA
42 meningococcemia 10.4 IL1RN IL1B IL1A
43 bullous impetigo 10.4 IL6 CALCA
44 uremic pruritus 10.4 IL6 IL1B
45 cryopyrin-associated periodic syndrome 10.4 IL6 IL1RN
46 prosthetic joint infection 10.4 TNFRSF11B IL6 IL1B
47 indolent myeloma 10.3 IL6 IL1RN IL1B
48 craniometaphyseal dysplasia, autosomal dominant 10.3 TNFSF11 TNFRSF11B RUNX2
49 multicentric reticulohistiocytosis 10.3 TNFSF11 TNFRSF11B
50 teeth hard tissue disease 10.3 TNFSF11 TNFRSF11B DSPP

Graphical network of the top 20 diseases related to Root Resorption:

Diseases related to Root Resorption

Symptoms & Phenotypes for Root Resorption

MGI Mouse Phenotypes related to Root Resorption:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.43 CALCR CTSK DMP1 IFIH1 IL1A IL1B
2 growth/size/body region MP:0005378 10.4 CTSK DMP1 IFIH1 IL1B IL1RN IL4
3 homeostasis/metabolism MP:0005376 10.39 CALCR CTSK DMP1 IFIH1 IL1A IL1B
4 immune system MP:0005387 10.39 CALCR CTSK DMP1 IFIH1 IL1A IL1B
5 cellular MP:0005384 10.34 CTSK DMP1 IFIH1 IL1RN IL4 IL6
6 cardiovascular system MP:0005385 10.28 DMP1 IL1A IL1B IL1RN IL6 MMP9
7 craniofacial MP:0005382 10.25 CTSK DMP1 IL1B IL4 RUNX2 SPARC
8 integument MP:0010771 10.25 IFIH1 IL1A IL1B IL1RN IL4 IL6
9 mortality/aging MP:0010768 10.13 CALCR IFIH1 IL1B IL1RN IL4 IL6
10 limbs/digits/tail MP:0005371 10.11 CALCR CTSK DMP1 MMP9 P2RX7 RUNX2
11 reproductive system MP:0005389 9.9 CTSK DMP1 IL1RN IL4 IL6 MMP9
12 neoplasm MP:0002006 9.86 IL1A IL1B IL6 MMP9 SPARC SPP1
13 respiratory system MP:0005388 9.56 CTSK IL4 IL6 MMP9 RUNX2 SPP1
14 skeleton MP:0005390 9.53 CALCR CTSK DMP1 IL1B IL1RN IL4

Drugs & Therapeutics for Root Resorption

Drugs for Root Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 75)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
2 Calcium, Dietary Phase 4
3 Caseins Phase 4
4 Fluorides Phase 4
5 Anti-Infective Agents Phase 2
6 Anti-Infective Agents, Local Phase 2
7 Dermatologic Agents Phase 2
8 Chlorhexidine gluconate Phase 2
9 Disinfectants Phase 2
10 Mitogens Phase 1
Salicylic acid Approved, Investigational, Vet_approved 69-72-7 338
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
leucovorin Approved 58-05-9 6006 143
Pemetrexed Approved, Investigational 150399-23-8, 137281-23-3 446556 60843
Epinephrine Approved, Vet_approved 51-43-4 5816
Lidocaine Approved, Vet_approved 137-58-6 3676
Racepinephrine Approved 329-65-7 838
Ketorolac Approved 74103-06-3, 66635-83-4 3826
Diclofenac Approved, Vet_approved 15307-86-5 3033
20 sodium fluoride Approved 7681-49-4
Copper Approved, Investigational 7440-50-8 27099
Hydrocodone Approved, Illicit, Investigational 125-29-1 5284569
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
Acetaminophen Approved 103-90-2 1983
Simvastatin Approved 79902-63-9 54454
Bacitracin Approved, Vet_approved 1405-87-4 439542 10909430
Polymyxin B Approved, Vet_approved 1404-26-8
Neomycin Approved, Vet_approved 1404-04-2 8378
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
30 Garlic Approved, Nutraceutical
31 Anesthetics, Local
32 Radiation-Protective Agents
33 Sunscreening Agents
34 Nutrients
35 Trace Elements
36 Micronutrients
37 Keratolytic Agents
38 Antifungal Agents
39 Folic Acid Antagonists
40 Vitamin B Complex
41 Vitamin B9
42 Folate
43 Epinephryl borate
Bismuth 7440-69-9 16682734 105143
45 Anti-Inflammatory Agents
46 Analgesics, Non-Narcotic
47 Anti-Inflammatory Agents, Non-Steroidal
48 Cyclooxygenase Inhibitors
49 Ketorolac Tromethamine
50 Antirheumatic Agents

Interventional clinical trials:

(show top 50) (show all 70)
# Name Status NCT ID Phase Drugs
1 The Use of MI Varnish for the Prevention and Reduction of White Spot Lesions in Orthodontic Treatment Completed NCT03446690 Phase 4 MI Varnish
2 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound in Human Subjects Unknown status NCT00423956 Phase 1, Phase 2
3 Histological Changes of The Dentinal-Pulp Complex and Root Resorption in Maxillary Premolars With Intrusive Orthodontic Movements Under a Low Power Laser Effect Completed NCT01642693 Phase 1, Phase 2
4 Evaluation of Effectiveness of Chlorhexidine Intracanal Medicament on Periodontal Healing in Concomitant Endodontic and Periodontal Disease With Communication : A Randomized Controlled Clinical Trial Completed NCT02627326 Phase 2
5 Periodontal Tissue Regeneration Using Autologous Periodontal Ligament Stem Cells: Randomized Controlled Clinical Trial Unknown status NCT01357785 Phase 1
6 Efficacy of Platelet-rich Plasma in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
7 Clinical/Numerical Study of the Effects of Periodontal Ligament Stress Level on the Rate Bodily Tooth Movement Completed NCT00099814 Phase 1
8 Clinical Observation for the Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206
9 A Randomized Clinical Trial to Evaluate Labial Alveolar Bone Thickness and Apical Root Resorption Between Two Kinds of Brackets Using CBCT Unknown status NCT02816489
10 Randomized Controlled Clinical Study Comparing Conventional and CAD/CAM-Based Treatment With Fixed Orthodontic Appliances Unknown status NCT00871026
11 Periodontally Accelerated Orthodontics - A Novel Technique For a Shortened Orthodontic Treatment With a Stable Result. A Clinical and Computerized Tomography Analysis Unknown status NCT01628575
12 Clinical Applicability of PBS® CIMMO Cement in Decoded Teeth Pulpotomies as Base and Restoration Unknown status NCT03200938
13 Compare the Clinical/Radiographic Outcomes of Potassium Nitrate in Polycarboxylate Cement and MTA as Pulpotomy Biomaterials Used for Asymptomatic Vital Immature Permanent Lower First Molars Unknown status NCT03166748
14 A Comparative CT Evaluation of the Amount of Root Resorption in Self-ligating Versus Conventional Brackets Completed NCT03613285
15 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Completed NCT02822040
16 A Clinical Comparison of the Effectiveness of Two Types of Orthodontic Aligning Archwire Materials: A Randomized Clinical Trial Completed NCT04090931
17 Placebo-Controlled, Randomized, Double Blind Trial of Effect of Photobiomodulation Therapies On The Root Resorption Associated With Orthodontic Forces: A Pilot Study Using Micro Computed Tomography Completed NCT04044989
18 Evaluation of the Efficiency of Corticision on Accelerating of Leveling and Alignment Lower Crowded Incisors Using Cone Beam Computed Tomography - A Randomized Controlled Trial Completed NCT03310086
19 The Effect of OrthoPulse™ on the Rate of Orthodontic Tooth Movement During Alignment With Fixed Appliances Completed NCT02267811
20 Assessment of Piezoelectric Periodontal Surgery Effects on Orthodontic Treatment: a Prospective Pilot Study Completed NCT02359760
21 Evaluation of Low-Level Laser Therapy (LLLT) Effectiveness in Accelerating Orthodontic Tooth Movement For Dental Crowding Cases: A Randomized Controlled Clinial Trial Completed NCT02568436
22 Evaluation of Treatment Outcomes of Corticotomy-accelerated Upper Incisors' Retraction: A Randomized Controlled Trial Completed NCT03149016
23 Evaluation of the Combined Effect of Corticotomy and Low Level Laser Therapy on the Rate of Orthodontic Tooth Movement: Split Mouth Randomized Clinical Trial Completed NCT03906084
24 Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth Completed NCT02740907
25 Comparison of Root Resorption, Microbial Colonization & Gingival Health Between Clear Aligners, Self-Ligating Brackets & Conventional Brackets- A Randomized Controlled Clinical Trial Completed NCT02745626
26 Checking Occlusion During Stainless Steel Crown Placement in Children Under General Anesthesia - Evaluation of a Novel Technique Completed NCT02437565
27 Is the 0.018-inch or the 0.022-inch Bracket Slot System More Effective in Orthodontic Treatment? A Randomized Clinical Trial. Completed NCT02080338
28 Evaluation the Efficacy of Rapid and Slow Maxillary Expansion in Posterior Crossbite Treatment Using Cone Beam Computed Tomography Completed NCT03667508
29 Evaluation of Post-operative Discomforts in Children After Extraction of Temporary Teeth _ DEXTRAFANT _ RC16_0183 Completed NCT03878173
30 Effect of Micro-osteoperforation on the Rate of Canine Retraction: A Split Mouth Randomized Controlled Trial Completed NCT03450278
31 The Effect of Pulpotomy (Partial or Complete) Using Resin-Modified Calcium Silicate Versus MTA-Anglus on Survival Rate of Cariously-Exposed Vital Young Permanent Molars:A Randomized Clinical Trial Completed NCT03119779 MTA-Anglus;TheraCal
32 Micro-osteoperforations and Tooth Movement: A Randomized Controlled Clinical Trial Completed NCT02473471
33 Evaluation of the Efficacy of Flapless Corticotomy Accomplished by Piezosurgery in Accelerating Orthodontic Treatment of Crowding in Adults: a Randomized Controlled Trial Completed NCT02977221
34 Evaluation of the Levels of Pain and Discomfort Between Piezosurgery-assisted Corticotomy Versus Traditional Method of Aligning Crowded Lower Anterior Teeth: a Randomized Controlled Trial Completed NCT02975765
35 Is Biodentine, as Successful as, Mineral Trioxide Aggregate for Pulpotomy of Primary Molars? A Split Mouth Clinical Trial Completed NCT03686475
36 The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo on Postoperative Pain in Teeth With Irreversible Pulpitis and Apical Periodontitis Completed NCT03116672 one dose ketorolac 10 mg;One dose Diclofenac;Placebo oral capsule
37 Success Rate of Three Capping Materials Used in Pulpotomy of Primary Molars: A Randomized Clinical Trial Completed NCT03833557
38 Comparison of Clinpro™ 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste, Clinpro™ Tooth Crème, and MI-Paste Plus for the Prevention and Reduction of White Spot Lesions in Orthodontic Treatment Completed NCT03440996
39 Evaluation the Efficacy of Flapless Corticotomy Accomplished by Either Hard-laser or Piezosurgey in Accelerating Upper Canine Retraction and Evaluation of the Dento-alveolar Changes and the Levels of Acceptance and Discomfort. Completed NCT02606331
40 Evaluation of Distal Movement of Maxillary Dentition With Zygomatic Miniplates: a Clinical Study Using Cone Beam Computed Tomography Completed NCT03467555
41 Evaluation the Dento-alveolar Changes After Platelet Rich Fibrin (i-PRF) Injection During Upper Canine Retraction Using Cone-beam Computed Tomography (CBCT) Completed NCT03399760
42 Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy: A Randomized Clinical Trial Completed NCT02119455
43 Correlation Between Root Resorption and Dentin Sialoprotein Upon Application of Different Orthodontic Forces, a Split-mouth Technique, a Randomized Clinical Trial Recruiting NCT03644537
44 Micro-osteoperforations To Reduce Orthodontic Treatment Duration: Randomised Controlled Clinical Trial Recruiting NCT03888560
45 Evaluation of the Effects of Osteoperforation and Piezocorticision on Canine Retraction: Randomized Controlled Clinical Trial. Recruiting NCT03308851
46 Autotransplantation of Teeth With Advanced or Completed Root Development With Intraoperative Extra-corporal Apicoectomy Recruiting NCT04041518
47 Evaluation of Low-Level Laser Therapy (LLLT) and Flapless Corticopuncture Effect on Accelerating Implant-Supported En-Masse Retraction of the Six Maxillary Anterior Teeth (Clinical Randomized Controlled Trial) Recruiting NCT03999307
48 Closed Window Technique Versus Open Window Technique in Management of Palatally Impacted Canines. A Randomized Clinical Trial Recruiting NCT02582645
49 Factors Affecting the Pulpal Prognosis of Injured Teeth Recruiting NCT03845426
50 A Three Dimensional Comparative Evaluation of Distal Movement of Entire Maxillary Dentition Using Infrazygomatic Crest Miniscrews and Zygomatic Miniplates: A Randomized Clinical Trial Recruiting NCT04191070

Search NIH Clinical Center for Root Resorption

Cochrane evidence based reviews: root resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

MalaCards organs/tissues related to Root Resorption:

Bone, Thyroid, Heart, Colon, Lung, Bone Marrow, Testes

Publications for Root Resorption

Articles related to Root Resorption:

(show top 50) (show all 3247)
# Title Authors PMID Year
Inhibitory effects of resveratrol on orthodontic tooth movement and associated root resorption in rats. 61
31887570 2020
A clinical comparison of the effectiveness of two types of orthodontic aligning archwire materials: a multicentre randomized clinical trial. 61
32011678 2020
Impact of pharmacologic inhibition of tooth movement on periodontal and tooth root tissues during orthodontic force application. 61
31593373 2020
Odontogenic keratocyst and ameloblastoma: radiographic evaluation. 61
32030659 2020
Incidence of incisor root resorption associated with the position of the impacted maxillary canines: A cone-beam computed tomographic study. 61
31901285 2020
Prevalence and severity of apical root resorption during orthodontic treatment with clear aligners and fixed appliances: a cone beam computed tomography study. 61
31903505 2020
Periodontal healing by periodontal ligament fiber with or without cells: A preclinical study of the decellularized periodontal ligament in a tooth replantation model. 61
31347702 2020
The role of sphingosine-1-phosphate signaling pathway in cementocyte mechanotransduction. 61
31941604 2020
Endodontic management of an autotransplanted mandibular third molar: A simplified approach. 61
31937403 2020
Atypical extraction treatment for failing replanted maxillary and mandibular incisors with space closure of 2 mandibular incisors in the same quadrant. 61
31901269 2020
Effects of systematic bisphosphonate use in patients under orthodontic treatment: a systematic review. 61
31009953 2020
Juvenile ossifying fibroma of the jaws and paranasal sinuses: a systematic review of the cases reported in the literature. 61
31285096 2020
Effect of interleukin-33 on cementoblast-mediated cementum repair during orthodontic tooth movement. 61
31986333 2020
External apical root resorption after nonextraction orthodontic treatment with labial vs. lingual fixed appliances. 61
31792608 2020
Clinical and histopathological characterization of root resorption in replanted teeth: Two case reports. 61
32011510 2020
Central giant cell granulomas of the jaws: retrospective radiographic analysis of 13 patients. 61
30825099 2020
Comparison of orthodontic root resorption of root-filled and vital teeth using micro-computed tomography. 61
31306075 2020
Incidence of root resorption after concussion, subluxation, lateral luxation, intrusion, and extrusion: a systematic review. 61
31953685 2020
Small case series suggests positive outcomes of vital pulp therapy for treating invasive cervical root resorption. 61
32005443 2020
NLRP3 inflammasome mediates M1 macrophage polarization and IL-1β production in inflammatory root resorption. 61
31976565 2020
Incisor root resorption associated with palatally displaced maxillary canines: Analysis and prediction using discriminant function analysis. 61
31901286 2020
Influence of anti-allergic drugs used systemically on the process of root resorption during delayed tooth replantation: A study in rats. 61
31845526 2019
External root resorption in maxillary and mandibular second molars associated with impacted third molars: a cone-beam computed tomographic study. 61
30793243 2019
Impact of CBCT on treatment decision related to surgical removal of impacted maxillary third molars: does CBCT change the surgical approach? 61
31452392 2019
[Risk during orthodontic treatment of the impacted teeth]. 61
31874481 2019
Effectiveness of miniscrew-supported maxillary incisor intrusion in deep-bite correction: A systematic review and meta-analysis. 61
31816252 2019
A bibliometric analysis of the top 50 most cited articles published in the Dental Traumatology. 61
31800153 2019
Influence of Trigonella foenum graecum seed extract as root canal irrigation agent on root surfaces: A scanning electron microscope/energy dispersive X-ray analysis study. 61
31444946 2019
Stable deep bite correction with true mandibular incisor intrusion in a late adolescent patient with skeletal deep bite: A case report. 61
31477527 2019
Root repair after damage due to screw insertion for orthodontic miniplate placement. 61
31824593 2019
[Research progress on the pathogenesis of inflammatory external root resorption]. 61
31875446 2019
Orthodontic treatment recommendation and expected adverse reactions in patients with a history of dental trauma: A survey among general dentists, paediatric dentists, and orthodontic specialists. 61
31803975 2019
CD8+ T lymphocytes enhance the anabolic effect of intermittent parathyroid hormone on cementoblasts. 61
31679847 2019
Microbiological Aspects of Traumatic Injuries. 61
31623904 2019
Microbiological aspects of traumatic injuries. 61
31125490 2019
Regenerative Endodontics: A Potential Solution for External Root Resorption (Case Series). 61
31813579 2019
Mini implants osseointegration, molar intrusion and root resorption in Sinclair minipigs. 61
31495755 2019
Phototherapy is unable to exert beneficial effects on orthodontic tooth movement in rat molars. 61
30920868 2019
Fourteen Years After Delayed Replantation of an Avulsed Permanent Tooth: Clinical Features and Outcomes. 61
31584555 2019
Biomarkers in the gingival crevicular fluid used to detect root resorption in patients undergoing orthodontic treatment: A systematic review. 61
31207100 2019
Effect of photobiomodulation therapies on the root resorption associated with orthodontic forces: a pilot study using micro computed tomography. 61
31773372 2019
Outcome of orthodontic treatment in subjects with periodontal disease. Part III: a CBCT study of external apical root resorption. 61
31165877 2019
Do electrical current and laser therapies improve bone remodeling during an orthodontic treatment with corticotomy? 61
30771000 2019
Effects of piezocision in orthodontic tooth movement: A systematic review of comparative studies. 61
31700581 2019
The Effectiveness of Micro-osteoperforations during Canine Retraction: A Three-dimensional Randomized Clinical Trial. 61
32039085 2019
Effects of Er:YAG Laser on the Attachment of Human Periodontal Ligament Fibroblasts to Denuded Root Surfaces Simulating Delayed Replantation Cases: An In Vitro Study. 61
31742487 2019
Optimal force magnitude for bodily orthodontic tooth movement with fixed appliances: A systematic review. 61
31677666 2019
The long-term fate of persisting deciduous molars and canines in 42 patients with severe hypodontia: a 12-year follow-up. 61
31750517 2019
[Three-dimensional finite element analysis on en-mass retraction of anterior teeth with clear aligner]. 61
31683382 2019
Intentional Replantation with an Atraumatic Extraction System in Teeth with Extensive Cervical Resorption. 61
31477262 2019

Variations for Root Resorption

Expression for Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for Root Resorption

Pathways related to Root Resorption according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
13.07 SPP1 P2RX7 MMP9 IL6 IL1B IFIH1
Show member pathways
Show member pathways
Show member pathways
Show member pathways
12.3 MMP9 IL6 IL4 IL1B
9 12.21 VDR IL6 IL1B IL1A
Show member pathways
12.19 IL6 IL1RN IL1B IL1A
11 12.15 IL6 IL1RN IL1B IL1A
Show member pathways
12 MMP9 IL6 IL4 IL1B
13 11.97 MMP9 IL6 IL4 IL1B IL1A
14 11.93 MMP9 IL6 IL4 IL1B IL1A
15 11.89 SPARC IL6 IL1B IL1A
16 11.85 IL6 IL4 IL1B IL1A
19 11.75 IL6 IL1B IL1A
20 11.73 IL6 IL1B IL1A
21 11.71 RUNX2 IL6 IL1B
22 11.65 SPP1 RUNX2 MMP9
23 11.65 MMP9 IL6 IL4 IL1RN IL1B
Show member pathways
11.62 MMP9 IL6 IL1B IL1A
25 11.59 SPARC DSPP DMP1
26 11.53 SPP1 MMP9 IL6 IL4 IL1B CALCA
27 11.5 IL6 IL1B IL1A
28 11.48 SPP1 RUNX2 MMP9
29 11.46 IL6 IL4 IL1RN IL1B IL1A
30 11.35 VDR TNFSF11 SPP1 RUNX2
31 11.33 IL6 IL1B IL1A
32 11.33 IL6 IL1B IL1A
33 11.27 IL6 IL4 IL1B
34 11.2 IL6 IL4 IL1B IL1A
36 11 TNFSF11 SPP1 IL6 IL4 IL1B IL1A
38 10.5 IL1B IL1A

GO Terms for Root Resorption

Cellular components related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 TNFSF11 TNFRSF11B SPP1 SPARC MMP9 IL6
2 vesicle GO:0031982 9.56 SPP1 SPARC IL1RN IL1B
3 extracellular matrix GO:0031012 9.55 TNFRSF11B SPARC MMP9 DSPP DMP1
4 extracellular region GO:0005576 9.47 TNFSF11 TNFRSF11B SPP1 SPARC MMP9 IL6

Biological processes related to Root Resorption according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.29 VDR TNFRSF11B TNFRSF11A SPP1 IL6 IL4
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.2 VDR TNFSF11 RUNX2 IL6 IL4 IL1B
3 immune response GO:0006955 10.06 TNFSF11 IL6 IL4 IL1RN IL1B IL1A
4 cellular protein metabolic process GO:0044267 9.96 SPP1 IL6 DMP1 CALCA
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.94 TNFSF11 IL1RN IL1B IL1A
6 response to lipopolysaccharide GO:0032496 9.93 TNFRSF11A SPARC P2RX7 IL1B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 TNFSF11 TNFRSF11A IL6 IL1B
8 cellular response to lipopolysaccharide GO:0071222 9.91 VDR IL6 IL1RN IL1B IL1A
9 inflammatory response GO:0006954 9.91 SPP1 P2RX7 IL6 IL1RN IL1B IL1A
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 TNFSF11 TNFRSF11A IL6 IL1B
11 skeletal system development GO:0001501 9.88 VDR TNFRSF11B RUNX2 MMP9 DSPP
12 extracellular matrix organization GO:0030198 9.88 TNFRSF11B SPP1 SPARC MMP9 DSPP DMP1
13 cytokine-mediated signaling pathway GO:0019221 9.87 TNFSF11 MMP9 IL6 IL4 IL1RN IL1B
14 neutrophil chemotaxis GO:0030593 9.85 IL1RN IL1B IL1A
15 positive regulation of JNK cascade GO:0046330 9.84 TNFSF11 IL1RN IL1B IL1A
16 positive regulation of T cell proliferation GO:0042102 9.83 IL6 IL4 IL1B
17 response to glucocorticoid GO:0051384 9.8 SPARC IL6 IL1RN CALCR
18 biomineral tissue development GO:0031214 9.78 SPP1 DSPP DMP1
19 osteoclast differentiation GO:0030316 9.77 TNFSF11 TNFRSF11A CALCR
20 monocyte chemotaxis GO:0002548 9.76 TNFSF11 TNFRSF11A IL6 CALCA
21 positive regulation of vascular endothelial growth factor production GO:0010575 9.74 IL6 IL1B IL1A
22 embryo implantation GO:0007566 9.73 SPP1 MMP9 IL1B CALCA
23 positive regulation of bone resorption GO:0045780 9.7 TNFSF11 TNFRSF11A SPP1
24 positive regulation of neuroinflammatory response GO:0150078 9.67 IL6 IL1B
25 regulation of neuroinflammatory response GO:0150077 9.67 MMP9 IL6
26 amylin receptor signaling pathway GO:0097647 9.65 CALCR CALCA
27 ectopic germ cell programmed cell death GO:0035234 9.65 IL1B IL1A
28 positive regulation of interleukin-6 production GO:0032755 9.65 P2RX7 IL6 IL1RN IL1B IL1A
29 positive regulation of prostaglandin secretion GO:0032308 9.64 P2RX7 IL1B
30 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.62 IL6 IL1RN
31 TNFSF11-mediated signaling pathway GO:0071847 9.61 TNFSF11 TNFRSF11A
32 fever generation GO:0001660 9.59 IL1B IL1A
33 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.56 TNFSF11 TNFRSF11A
34 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.55 TNFSF11 TNFRSF11A
35 negative regulation of bone resorption GO:0045779 9.46 TNFRSF11B P2RX7 IL6 CALCA
36 ossification GO:0001503 9.43 TNFSF11 TNFRSF11A SPARC RUNX2 DSPP DMP1
37 positive regulation of gene expression GO:0010628 9.28 VDR TNFSF11 RUNX2 P2RX7 IL6 IL4

Molecular functions related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 VDR TNFSF11 TNFRSF11B TNFRSF11A SPP1 SPARC
2 signaling receptor activity GO:0038023 9.67 VDR TNFRSF11B TNFRSF11A P2RX7
3 collagen binding GO:0005518 9.46 SPARC MMP9 DSPP CTSK
4 extracellular matrix binding GO:0050840 9.43 SPP1 SPARC DMP1
5 cytokine activity GO:0005125 9.23 TNFSF11 TNFRSF11B SPP1 IL6 IL4 IL1RN
6 interleukin-1 receptor binding GO:0005149 9.13 IL1RN IL1B IL1A

Sources for Root Resorption

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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