Aliases & Classifications for Root Resorption

MalaCards integrated aliases for Root Resorption:

Name: Root Resorption 12 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14550
MeSH 44 D012391
UMLS 73 C0035851

Summaries for Root Resorption

MalaCards based summary : Root Resorption is related to chronic apical periodontitis and tooth resorption. An important gene associated with Root Resorption is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Mitogens and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include bone and thyroid, and related phenotypes are hematopoietic system and growth/size/body region

Related Diseases for Root Resorption

Diseases related to Root Resorption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 chronic apical periodontitis 30.7 TNFRSF11B TNFSF11
2 tooth resorption 30.4 CTSK DSPP TNFRSF11A TNFRSF11B TNFSF11
3 pulpitis 28.9 DSPP IL1A IL1B
4 hypercementosis 28.9 CTSK DSPP SPP1 TNFRSF11A
5 periodontitis 28.2 CTSK IL1A IL1B RUNX2 TNFRSF11B TNFSF11
6 periodontal disease 27.9 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
7 singleton-merten syndrome 1 11.0
8 prosthetic joint infection 10.8 IL1B TNFRSF11B
9 multicentric reticulohistiocytosis 10.7 TNFRSF11B TNFSF11
10 kummell's disease 10.7 TNFRSF11B TNFSF11
11 breast leiomyosarcoma 10.7 TNFRSF11A TNFSF11
12 vulvar vestibulitis syndrome 10.7 IL1B IL1RN
13 autoimmune myocarditis 10.7 IL1B SPP1
14 gastric cancer, hereditary diffuse 10.6 IL1B IL1RN
15 schnitzler syndrome 10.6 IL1B IL1RN
16 cerebral artery occlusion 10.6 IL1B IL1RN
17 osteosclerotic myeloma 10.6 IL1B IL1RN
18 fibrogenesis imperfecta ossium 10.6 CALCA TNFRSF11B
19 periostitis 10.6 IL1RN TNFRSF11A
20 giant cell reparative granuloma 10.5 CALCA TNFRSF11A
21 periodontitis, chronic 10.5 IL1B TNFRSF11B TNFSF11
22 hydrarthrosis 10.5 IL1B IL1RN
23 polyarticular onset juvenile idiopathic arthritis 10.4 TNFRSF11A TNFRSF11B TNFSF11
24 hemophilic arthropathy 10.4 TNFRSF11A TNFRSF11B TNFSF11
25 cervicitis 10.4
26 familial expansile osteolysis 10.4 TNFRSF11A TNFRSF11B TNFSF11
27 joint disorders 10.4 IL1B IL1RN TNFSF11
28 amyloid tumor 10.4 CALCA IL1RN
29 cinca syndrome 10.4 IL1B IL1RN
30 hypophosphatasia, adult 10.4 CALCA SPP1
31 vaginal disease 10.4 DSPP IL1B
32 dentin dysplasia, type ii 10.4 DSPP SPP1
33 endometrial disease 10.3 DSPP IL1B
34 dental pulp disease 10.3 DSPP IL1B
35 dental pulp calcification 10.3 DSPP SPP1
36 aneurysmal bone cysts 10.3 CALCA TNFRSF11A TNFSF11
37 endosteal hyperostosis, autosomal dominant 10.2 CTSK TNFRSF11B TNFSF11
38 secondary hyperparathyroidism of renal origin 10.2 CALCA TNFRSF11B
39 teeth, supernumerary 10.2 DSPP RUNX2
40 osteopetrosis 10.2 CTSK TNFRSF11A TNFSF11
41 dentin dysplasia 10.2 DSPP SPP1
42 chronic follicular conjunctivitis 10.1 IL1A IL1B
43 osteonecrosis 10.1 RUNX2 TNFRSF11B TNFSF11
44 gingivitis 10.1
45 adult-onset still's disease 10.1 IL1B IL1RN
46 synovitis 10.1 IL1B IL1RN TNFRSF11B TNFSF11
47 breast adenocarcinoma 10.1 CALCA CTSK TNFSF11
48 irritant dermatitis 10.1 IL1A IL1B
49 trichorhinophalangeal syndrome, type i 10.0 RUNX2 TNFRSF11B
50 aortic valve disease 1 10.0 RUNX2 SPP1 TNFRSF11B

Graphical network of the top 20 diseases related to Root Resorption:



Diseases related to Root Resorption

Symptoms & Phenotypes for Root Resorption

MGI Mouse Phenotypes related to Root Resorption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 IL1B SPP1 IL1RN CTSK P2RX7 IL1A
2 growth/size/body region MP:0005378 10.09 RUNX2 IL1B SPP1 IL1RN CTSK P2RX7
3 cardiovascular system MP:0005385 10.02 IL1A RUNX2 IL1B SPP1 IL1RN P2RX7
4 homeostasis/metabolism MP:0005376 10.02 RUNX2 IL1B SPP1 IL1RN CTSK P2RX7
5 immune system MP:0005387 10.02 RUNX2 IL1B SPP1 IL1RN CTSK P2RX7
6 craniofacial MP:0005382 10 RUNX2 IL1B SPP1 CTSK TNFRSF11B TNFSF11
7 integument MP:0010771 9.86 RUNX2 IL1B SPP1 IL1RN P2RX7 IL1A
8 limbs/digits/tail MP:0005371 9.63 RUNX2 CTSK P2RX7 TNFRSF11B TNFSF11 TNFRSF11A
9 neoplasm MP:0002006 9.35 IL1A IL1B SPP1 TNFSF11 TNFRSF11A
10 skeleton MP:0005390 9.28 IL1B SPP1 IL1RN TNFRSF11A CTSK P2RX7

Drugs & Therapeutics for Root Resorption

Drugs for Root Resorption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Mitogens Phase 1
2
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
3
Copper Approved, Investigational Not Applicable 7440-50-8 27099
4
Salicylic acid Approved, Investigational, Vet_approved Not Applicable 69-72-7 338
5
Miconazole Approved, Investigational, Vet_approved Not Applicable 22916-47-8 4189
6
Chlorhexidine Approved, Vet_approved Not Applicable 55-56-1 9552079 2713
7
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
8
Racepinephrine Approved Not Applicable 329-65-7 838
9
Alginic acid Approved, Investigational Not Applicable 9005-32-7
10
Menthol Approved Not Applicable 2216-51-5 16666
11
Zinc Approved, Investigational Not Applicable 7440-66-6 23994
12
Zinc oxide Approved Not Applicable 1314-13-2
13 Orange Approved, Nutraceutical Not Applicable
14 Sodium hypochlorite Early Phase 1
15 Anesthetics Not Applicable
16 Anesthetics, Local Not Applicable
17 Disinfectants Early Phase 1
18 Eusol Early Phase 1
19 Anti-Infective Agents Early Phase 1,Not Applicable
20
Nickel Not Applicable 7440-02-0 934
21 Chlorhexidine gluconate Not Applicable
22 Analgesics Not Applicable
23 Central Nervous System Depressants Not Applicable
24 Dermatologic Agents Not Applicable
25 Anti-Bacterial Agents Not Applicable
26 Epinephryl borate Not Applicable
27 Antibiotics, Antitubercular Not Applicable
28 Antifungal Agents Not Applicable
29 Keratolytic Agents Not Applicable
30 Anti-Inflammatory Agents Not Applicable
31 Bone Density Conservation Agents Not Applicable
32 Calcium, Dietary Not Applicable
33 Coagulants Not Applicable
34 Hemostatics Not Applicable
35 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show top 50) (show all 58)
# Name Status NCT ID Phase Drugs
1 MEDCEM PC and MTA in Pulpotomies of Primary Molars Unknown status NCT02291120 Phase 4
2 Vital Pulp Treatment in Primary Teeth Recruiting NCT02298504 Phase 4 Mineral Trioxide Aggregate;Biodentin;Vitrebond
3 Biodentine Versus White MTA Pulpotomy Unknown status NCT01733420 Phase 3 Biodentine pulpotomy;White MTA pulpotomy;Tempophore pulpotomy
4 Endodontic Treatment of Necrotic Primary Teeth With Guedes Pinto Paste: A Randomized Clinical Trial Completed NCT02216942 Phase 3 Endodontic treatment using Vitapex;Endodontic treatment using Guedes Pinto
5 Repair of Orthodontically-induced Tooth Root Resorption by Ultrasound Unknown status NCT00423956 Phase 1, Phase 2
6 Histological Change of The Dentinal-Pulp Complex and Root Resorption Completed NCT01642693 Phase 1, Phase 2
7 Endodontic Treatment of Primary Teeth Using Mineral Trioxide Aggregate Paste Completed NCT02887456 Phase 2 Endodontic treatment using Vitapex;Endodontic treatment using MTA paste
8 Use of PRP in Treatment of Mandibular Traumatic Bone Cyst Completed NCT01944410 Phase 1
9 Periodontal Ligament Stress Level and Tooth Movement Completed NCT00099814 Phase 1
10 Labial Alveolar Bone Thickness and Apical Root Resorption Changes Associated With Self-ligating Versus Conventional Brackets Unknown status NCT02816489 Not Applicable
11 Volumetric Analysis of Root Resorption With Mini-Screw Implant Anchorage-assisted Retraction of Maxillary Incisors Unknown status NCT02221206 Not Applicable
12 Periodontally Accelerated Orthodontics - A Novel Technique For a Shortened Orthodontic Treatment With a Stable Result. A Clinical and Computerized Tomography Analysis Unknown status NCT01628575
13 Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) - Based Planning and Creation of Orthodontic Appliances Unknown status NCT00871026 Not Applicable
14 Sodium Hypochlorite Pulpotomies in Primary Molars: Comparison With Conventional 20% Formocresol Pulpotomies Unknown status NCT02137967 Early Phase 1 2.5% NaOCl;20% Formocresol
15 Comparison of Oral Hygiene & Root Resorption During Orthodontic Treatment Completed NCT02745626 Not Applicable
16 An Evaluation of Root Length Measurements Using Intraoral Scan and Panoramic Radiographs Completed NCT02822040
17 Effect of Pulpotomy Using TheraCal Versus MTA on Survival Rate of Cariously-Exposed Vital Permanent Molars Completed NCT03119779 Not Applicable MTA-Anglus;TheraCal
18 The Effect of Ultrasound on Orthodontic Tooth Movement Completed NCT01828164 Not Applicable
19 Micro-osteoperforations and Tooth Movement Completed NCT02473471 Not Applicable
20 Premolar Autotransplantation in Juvenile Dentition: Quantitative Assessment of Vertical Bone and Soft Tissue Growth Completed NCT02740907
21 Assessment of Piezoelectric Periodontal Surgery Effects on Orthodontic Treatment: a Prospective Pilot Study Completed NCT02359760 Not Applicable
22 Checking Occlusion During Stainless Steel Crown Placement Completed NCT02437565 Not Applicable
23 Efficiency of Piezocision-assisted Orthodontic Treatment in Adult Patients Completed NCT02590835 Not Applicable
24 Intermittent Vibrational Force and Orthodontic Tooth Movement Completed NCT02314975 Not Applicable
25 Effect of Liners on Pulpal Outcome and Restoration Survival After Partial Caries Excavation Completed NCT03286959 Not Applicable
26 Antimicrobial Pastes and Clinical Cases of Apexogenesis Completed NCT03112291 Not Applicable
27 The Effect of Laser Combined With Pulp-capping Agents on Direct Pulp Capping Completed NCT02487329 Not Applicable
28 Effect of Micro-osteoperforation on the Rate of Canine Retraction Completed NCT03450278 Not Applicable
29 Evaluation of Post Operative Pain Following Indirect Pulp Capping Using Antibacterial Bonding System Completed NCT02930135 Not Applicable
30 Evaluation of Periodontal Ligament Distraction Using a Modified Surgical Technique for Retraction of Maxillary Canines Completed NCT03535285 Not Applicable
31 Efficacy and the Safety Study of RD94 in Patients With Endodontic Care Completed NCT01737229 Not Applicable
32 0.018 or 0.022 Bracket Slot System More Effective in Orthodontic Treatment? Completed NCT02080338 Not Applicable
33 Orthodontic Archwire Comparison Trial Recruiting NCT02983084 Not Applicable
34 Efficacy of Injectable Platelet Rich Fibrin (i-PRF) in Enhancing Bone Quality Recruiting NCT03399760 Not Applicable
35 Evaluation of the Effects of Osteoperforation and Piezocorticision on Canine Retraction Recruiting NCT03308851 Not Applicable
36 The Effect of Different Force Magnitudes on Maxillary Posterior Segment Intrusion Recruiting NCT02901678 Not Applicable
37 The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances Recruiting NCT03202355 Not Applicable
38 Assessment of Vital Pulp Therapy in Permanent Molars Recruiting NCT03410134 Not Applicable
39 Mechanized Instrumentation for Endodontic Treatment of Primary Teeth Recruiting NCT03453658 Not Applicable
40 Closed Window vs. Open Window Technique in Management of Palatally Impacted Canines Recruiting NCT02582645 Not Applicable
41 Crossbow Versus Forsus Springs in Mild to Moderate Class II Malocclusion Cases Active, not recruiting NCT01530516 Not Applicable
42 Application of Different Biomaterials in the Preservation of Vital Pulp in Carious Deciduous Teeth Active, not recruiting NCT03220360 Not Applicable
43 The Effect of OrthoPulse™ Photobiomodulation on Tooth Movement and Treatment Time When Used With Invisalign Treatment Active, not recruiting NCT02954133 Not Applicable
44 The Impact of Surgical Technique on PDC Active, not recruiting NCT02186548 Not Applicable
45 The Use of Corticotomy for Upper Incisors Retraction Active, not recruiting NCT03149016 Not Applicable
46 Treatment of Crowding Without Extraction Using Self Ligating Brackets Active, not recruiting NCT02996292 Not Applicable
47 Biomarkers of Orthodontic Tooth Movement With Fixed Appliances and Vibration Appliance Therapy Active, not recruiting NCT02119455 Not Applicable
48 Acceleration of Lower Anterior Teeth Leveling and Alignment Using Corticision Active, not recruiting NCT03310086 Not Applicable
49 Evaluation of Distal Movement of Maxillary Dentition With Zygomatic Miniplates Using Cone Beam Computed Tomography Active, not recruiting NCT03467555 Not Applicable
50 Comparison of MedCem MTA and Formocresol Used in Pulpotomies in Primary Teeth. Active, not recruiting NCT01962077 Not Applicable

Search NIH Clinical Center for Root Resorption

Cochrane evidence based reviews: root resorption

Genetic Tests for Root Resorption

Anatomical Context for Root Resorption

MalaCards organs/tissues related to Root Resorption:

41
Bone, Thyroid

Publications for Root Resorption

Articles related to Root Resorption:

(show top 50) (show all 679)
# Title Authors Year
1
Lithium chloride reduces orthodontically induced root resorption and affects tooth root movement in rats. ( 29607672 )
2018
2
The effect of biologic factors and adjunctive therapies on orthodontically induced inflammatory root resorption: a systematic review and meta-analysis. ( 29617793 )
2018
3
Factors Associated to Apical Root Resorption after Orthodontic Treatment. ( 29875885 )
2018
4
Volumetric evaluation of root resorption on the upper incisors using cone beam computed tomography after 1 year of orthodontic treatment in adult patients with marginal bone loss. ( 29911905 )
2018
5
A comparative study of the effect of the intrusion arch and straight wire mechanics on incisor root resorption: A randomized, controlled trial. ( 28985106 )
2018
6
Root resorption due to orthodontic treatment using self-ligating and conventional brackets : AA cone-beam computed tomography study. ( 29651519 )
2018
7
Evaluation of orthodontically induced external root resorption following orthodontic treatment using cone beam computed tomography (CBCT): a systematic review and meta-analysis. ( 29771300 )
2018
8
Apical root resorption during orthodontic treatment with clear aligners: A retrospective study using cone-beam computed tomography. ( 29853242 )
2018
9
Accuracy of Digital Periapical Radiography and Cone-beam Computed Tomography for Diagnosis of Natural and Simulated External Root Resorption. ( 29884337 )
2018
10
Comparison between Two Radiological Methods for Assessment of Tooth Root Resorption: An In Vitro Study. ( 29687001 )
2018
11
Obturation quality of calcium silicate-based cements placed with different techniques in teeth with perforating internal root resorption: a micro-computed tomographic study. ( 29872920 )
2018
12
Evaluation of root resorption after comprehensive orthodontic treatment using cone beam computed tomography (CBCT): a meta-analysis. ( 29945577 )
2018
13
Effect of EMD on the orthodontically induced root resorption repair process in rats. ( 29396597 )
2018
14
The ins and outs of root resorption. ( 29747189 )
2018
15
Incidence of Root Resorption after the Replantation of Avulsed Teeth: A Meta-analysis. ( 29866405 )
2018
16
The effects of three modified Hank's balanced salt solutions on root resorption of late replanted teeth: A pilot study. ( 29545029 )
2018
17
Physical properties of root cementum: Part 26. Effects of micro-osteoperforations on orthodontic root resorption: A microcomputed tomography study. ( 29407497 )
2018
18
Intrinsic Hormone-Like Molecules and External Root Resorption During Orthodontic Tooth Movement. A Systematic Review and Meta-Analysis in Preclinical <i>in-Vivo</i> Research. ( 29643818 )
2018
19
Autotransplantation, Surgical Repositioning of Retained Canine, and Apical Filling of Two Incisors with Root Resorption. ( 29707027 )
2018
20
Bilateral root resorption of maxillary i-8rst permanent molars by unerupted second molars associated with orthodontic distalisation. ( 29976113 )
2018
21
A pilot study of the metabolomic profiles of saliva from female orthodontic patients with external apical root resorption. ( 29291387 )
2018
22
Effects of loxoprofen on the apical root resorption during orthodontic tooth movement in rats. ( 29694352 )
2018
23
External apical root resorption. ( 29287651 )
2018
24
External apical root resorption diagnosis by using FII human dentine fraction and salivary IGg. ( 29628427 )
2018
25
Effect of root canal obturation with calcium silicate materials on pH change in simulated root resorption defects. ( 29714703 )
2018
26
Comparison of 4 and 6A weeks of rest period for repair of root resorption. ( 28670661 )
2017
27
Management of root resorption with mineral trioxide aggregate complicated by a luxation injury: report of a case with six-year follow-up. ( 28065972 )
2017
28
Multidisciplinary approach for replacement a8"root resorption following severe intrusive luxation: a8"A case report of decoronation. ( 28555199 )
2017
29
Some historical musings on tooth/root resorption. ( 29354305 )
2017
30
Cellular and Molecular Pathways Leading to External Root Resorption. ( 27811065 )
2017
31
Analysis of the association of clinical factors and IL4 gene polymorphisms with root resorption in avulsed teeth after 1A year of replantation. ( 28617966 )
2017
32
Assessment of Root Resorption and Root Shape by Periapical and Panoramic Radiographs: A Comparative Study. ( 28621278 )
2017
33
Comparison between anterior segmental osteotomy versus conventional orthodontic treatment in root resorption: a radiographic study using cone-beam computed tomography. ( 29204418 )
2017
34
Decoronation: An Alternative Treatment for Replacement Root Resorption. ( 28573052 )
2017
35
Dimensional Evaluation of Root Resorption Areas in Differing Severity of Chronic Periodontitis: A Scanning Electron Microscopic Study. ( 29042731 )
2017
36
Effects of short-term in-vivo studies on orthodontic root resorption paradigms. ( 28651756 )
2017
37
A preliminary investigation of short-termA cytokineA expression in gingival crevicular fluid secondary to high-level orthodontic forces and the associated root resorption: case series analytical study. ( 28762151 )
2017
38
Management of Invasive Cervical Root Resorption in a Mandibular Canine Using Biodentine as a Restorative Material: A Case Report. ( 28808471 )
2017
39
The effect of low-level laser therapy on orthodontically induced root resorption: a pilot double blind randomized controlled trial. ( 29016741 )
2017
40
Incisor root resorption in class II division 2 patients in relation to orthodontic treatment. ( 29161376 )
2017
41
The Role of Varicella Zoster Virus in the Development of Periapical Pathoses and Root Resorption: A Systematic Review. ( 28662875 )
2017
42
Piezocision and root resorption: AA biased conclusion? ( 28554442 )
2017
43
Markers in blood and saliva for prediction of orthodontically induced inflammatory root resorption: a retrospective case controlled-study. ( 28782095 )
2017
44
Comparative study of root resorption of maxillary incisors in patients treated with lingual and buccal orthodontics. ( 28737425 )
2017
45
The relationships between the arrangement of teeth, root resorption, and dental maturity in bovine mandibular incisors. ( 29090124 )
2017
46
The Alpha 7 Nicotinic Acetylcholine Receptor of Deciduous Dental Pulp Stem Cells Regulates Osteoclastogenesis During Physiological Root Resorption. ( 28494644 )
2017
47
Diagnostic accuracy of phosphor plate systems and conventional radiography in the detection of simulated internal root resorption. ( 28754080 )
2017
48
Effects of corticopuncture (CP) and low-level laser therapy (LLLT) on the rate of tooth movement and root resorption in rats using micro-CT evaluation. ( 29282560 )
2017
49
Three consecutive days of application of LED therapy is necessary to inhibit experimentally induced root resorption in rats: a microtomographic study. ( 27796672 )
2017
50
Management of Ankylotic Root Resorption Following Dental Trauma: A Short Review and Proposal of a Treatment Protocol. ( 28761940 )
2017

Variations for Root Resorption

Expression for Root Resorption

Search GEO for disease gene expression data for Root Resorption.

Pathways for Root Resorption

Pathways related to Root Resorption according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CTSK IL1A IL1B IL1RN P2RX7 TNFRSF11A
2
Show member pathways
13.11 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
3
Show member pathways
12.44 IL1B TNFRSF11A TNFRSF11B TNFSF11
4 12.35 IL1B IL1RN TNFRSF11A TNFSF11
5
Show member pathways
12.25 IL1B IL1RN TNFRSF11A TNFSF11
6
Show member pathways
12.2 IL1A IL1B TNFRSF11A TNFSF11
7
Show member pathways
12.18 CTSK TNFRSF11A TNFRSF11B TNFSF11
8
Show member pathways
12.09 IL1A IL1B IL1RN
9
Show member pathways
12 IL1A IL1B IL1RN
10 11.96 IL1A IL1B IL1RN
11 11.74 CTSK IL1A IL1B TNFRSF11A TNFRSF11B TNFSF11
12 11.66 IL1B TNFRSF11A TNFSF11
13 11.61 CTSK IL1A IL1B TNFRSF11A TNFSF11
14 11.41 CALCA IL1B SPP1
15 11.27 IL1A IL1B IL1RN
16 11.16 IL1A IL1B
17 11.16 IL1A IL1B
18 11.09 RUNX2 SPP1 TNFSF11
19 11.07 IL1A IL1B
20 11.06 TNFRSF11B TNFSF11
21 10.88 CALCA IL1A IL1B RUNX2 SPP1 TNFRSF11A
22 10.69 TNFRSF11B TNFSF11
23 10.56 CTSK SPP1 TNFRSF11A TNFRSF11B TNFSF11
24 10.3 IL1A IL1B

GO Terms for Root Resorption

Cellular components related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CALCA CTSK IL1A IL1B IL1RN SPP1
2 vesicle GO:0031982 9.33 IL1B IL1RN SPP1
3 extracellular region GO:0005576 9.28 CALCA CTSK DSPP IL1A IL1B IL1RN

Biological processes related to Root Resorption according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.92 IL1A IL1B P2RX7 RUNX2
2 cytokine-mediated signaling pathway GO:0019221 9.88 IL1A IL1B IL1RN TNFSF11
3 extracellular matrix organization GO:0030198 9.85 DSPP SPP1 TNFRSF11B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 IL1A IL1B TNFSF11
5 response to lipopolysaccharide GO:0032496 9.83 IL1B P2RX7 TNFRSF11A TNFRSF11B
6 skeletal system development GO:0001501 9.82 DSPP RUNX2 TNFRSF11B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.82 IL1B TNFRSF11A TNFSF11
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNFRSF11A TNFRSF11B TNFSF11
9 immune response GO:0006955 9.8 IL1A IL1B IL1RN TNFRSF11A TNFRSF11B TNFSF11
10 positive regulation of DNA binding transcription factor activity GO:0051091 9.79 IL1B TNFRSF11A TNFSF11
11 interleukin-1-mediated signaling pathway GO:0070498 9.77 IL1A IL1B IL1RN
12 apoptotic signaling pathway GO:0097190 9.75 P2RX7 TNFRSF11A TNFRSF11B
13 positive regulation of JNK cascade GO:0046330 9.72 IL1A IL1B TNFSF11
14 positive regulation of interleukin-6 production GO:0032755 9.71 IL1A IL1B P2RX7
15 ossification GO:0001503 9.71 DSPP RUNX2 TNFRSF11A TNFSF11
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 IL1A IL1B
17 biomineral tissue development GO:0031214 9.68 DSPP SPP1
18 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.68 IL1A IL1B
19 osteoclast differentiation GO:0030316 9.67 TNFRSF11A TNFSF11
20 positive regulation of cytokine secretion GO:0050715 9.67 IL1A P2RX7
21 positive regulation of interleukin-8 production GO:0032757 9.67 CALCA IL1B
22 monocyte chemotaxis GO:0002548 9.67 CALCA TNFRSF11A TNFSF11
23 positive regulation of vascular endothelial growth factor production GO:0010575 9.66 IL1A IL1B
24 positive regulation of mitotic nuclear division GO:0045840 9.66 IL1A IL1B
25 bone resorption GO:0045453 9.65 CTSK TNFSF11
26 embryo implantation GO:0007566 9.65 CALCA IL1B SPP1
27 response to ATP GO:0033198 9.64 IL1B P2RX7
28 mammary gland alveolus development GO:0060749 9.63 TNFRSF11A TNFSF11
29 positive regulation of ossification GO:0045778 9.62 CALCA P2RX7
30 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.61 IL1A IL1B
31 positive regulation of monocyte chemotactic protein-1 production GO:0071639 9.6 IL1A IL1B
32 ectopic germ cell programmed cell death GO:0035234 9.57 IL1A IL1B
33 positive regulation of prostaglandin secretion GO:0032308 9.56 IL1B P2RX7
34 positive regulation of bone resorption GO:0045780 9.54 SPP1 TNFRSF11A TNFSF11
35 TNFSF11-mediated signaling pathway GO:0071847 9.51 TNFRSF11A TNFSF11
36 regulation of signaling receptor activity GO:0010469 9.5 CALCA IL1A IL1B IL1RN SPP1 TNFRSF11B
37 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.46 TNFRSF11A TNFSF11
38 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.43 TNFRSF11A TNFSF11
39 negative regulation of bone resorption GO:0045779 9.43 CALCA P2RX7 TNFRSF11B
40 fever generation GO:0001660 9.33 IL1A IL1B IL1RN
41 inflammatory response GO:0006954 9.23 CALCA IL1A IL1B IL1RN P2RX7 SPP1

Molecular functions related to Root Resorption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 9.16 TNFRSF11A TNFRSF11B
2 interleukin-1 receptor binding GO:0005149 9.13 IL1A IL1B IL1RN
3 cytokine activity GO:0005125 9.1 IL1A IL1B IL1RN SPP1 TNFRSF11B TNFSF11

Sources for Root Resorption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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