MCID: RBS002
MIFTS: 32

Rubeosis Iridis

Categories: Eye diseases

Aliases & Classifications for Rubeosis Iridis

MalaCards integrated aliases for Rubeosis Iridis:

Name: Rubeosis Iridis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:14000
ICD9CM 34 364.42
SNOMED-CT 67 51995000
ICD10 32 H21.1
UMLS 71 C0154916

Summaries for Rubeosis Iridis

MalaCards based summary : Rubeosis Iridis is related to neovascular glaucoma and central retinal vein occlusion. An important gene associated with Rubeosis Iridis is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Cell adhesion_ECM remodeling and Cell adhesion_Plasmin signaling. The drugs Antineoplastic Agents, Immunological and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain.

Wikipedia : 74 Rubeosis iridis, is a medical condition of the iris of the eye in which new abnormal blood vessels... more...

Related Diseases for Rubeosis Iridis

Diseases related to Rubeosis Iridis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 neovascular glaucoma 31.2 VEGFA PLG
2 central retinal vein occlusion 30.8 VEGFA PLG
3 branch retinal artery occlusion 30.1 VEGFA PLG FANCG
4 retinal artery occlusion 30.1 VEGFA PLG FANCG
5 central retinal artery occlusion 30.1 VEGFA PLG FANCG
6 intraocular pressure quantitative trait locus 11.0
7 microvascular complications of diabetes 5 10.9
8 retinal detachment 10.8
9 retinal vein occlusion 10.7
10 microvascular complications of diabetes 1 10.7
11 microvascular complications of diabetes 2 10.7
12 uveitis 10.7
13 retinal ischemia 10.6
14 retinoblastoma 10.5
15 familial retinoblastoma 10.5
16 cataract 10.5
17 vitreoretinopathy, neovascular inflammatory 10.4
18 iritis 10.4
19 retinal vascular disease 10.4
20 eye disease 10.4
21 vasculitis 10.4
22 iridocyclitis 10.4
23 vitreoretinopathy 10.4
24 choroid cancer 10.3 VEGFA FANCG
25 chorioretinal scar 10.3 VEGFA FANCG
26 hypertensive retinopathy 10.2 VEGFA FANCG
27 multiple sclerosis 10.2
28 sarcoidosis 1 10.2
29 sturge-weber syndrome 10.2
30 yemenite deaf-blind hypopigmentation syndrome 10.2
31 open-angle glaucoma 10.2
32 blind hypotensive eye 10.2
33 allergic hypersensitivity disease 10.2
34 optic neuritis 10.2
35 intermediate uveitis 10.2
36 carotid stenosis 10.2
37 diabetic cataract 10.2
38 primary angle-closure glaucoma 10.2
39 ectropion 10.2
40 vascular disease 10.2
41 neuritis 10.2
42 melanoma 10.2
43 hemoglobin c disease 10.2
44 demyelinating disease 10.2
45 adenoma 10.2
46 myotonic dystrophy 10.2
47 47,xyy 10.2
48 weber syndrome 10.2
49 acquired color blindness 10.1 PRSS21 LAMA3
50 cholesterol embolism 9.9 PLG MARCHF2

Comorbidity relations with Rubeosis Iridis via Phenotypic Disease Network (PDN):


Hypertension, Essential Microvascular Complications of Diabetes 1
Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Rubeosis Iridis:



Diseases related to Rubeosis Iridis

Symptoms & Phenotypes for Rubeosis Iridis

Drugs & Therapeutics for Rubeosis Iridis

Drugs for Rubeosis Iridis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antineoplastic Agents, Immunological Phase 4
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3 Anecortave Investigational Phase 2 10184-70-0
4
Triamcinolone Approved, Vet_approved 124-94-7 31307
5 Hormone Antagonists
6 Immunologic Factors
7 Triamcinolone hexacetonide
8 Anti-Inflammatory Agents
9 triamcinolone acetonide
10 Triamcinolone diacetate
11 glucocorticoids
12 Immunosuppressive Agents
13 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The RAVE (Rubeosis Anit-VEgf) Trial, Utilizes Monthly Intravitreal Bevazizumab (Avastin) Injections for 12 Months to See if Total VEGF Blockade Will Prevent Neovascular Glaucoma and Eliminate the Need for Panretinal Photocoagulation in Patients With Ischemic Central Retinal Vein Occlusion Completed NCT00557232 Phase 4 bevacizumab
2 Intravitreal Aflibercept or Ranibizumab for Rubeosis Iridis Completed NCT02641457 Phase 3 Aflibercept;Ranibizumab
3 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy With Intravitreal Injection of Lucentis (Ranibizumab Injection) Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
4 Phase 2 Ziv-aflibercept in Ocular Disease Short and Long-term Study Recruiting NCT02486484 Phase 2 ziv-aflibercept
5 Treatment of Rubeosis Iridis With Open-Label Anecortave Acetate Sterile Suspension (15mg.). Terminated NCT00211471 Phase 2 anecortave acetate
6 Randomized Controlled Trial of Lucentis in the Management of New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
7 Ranibizumab in Subjects With Dense Cataract and Rubeosis Due to Proliferative Diabetic Retinopathy (PDR) Completed NCT01069341 Phase 1 Ranibizumab
8 Comparative,Randomized Study Between Intravitreal Triamcinolone Acetonide and Air-Fluid Exchange in Eyes With Post Vitrectomy Diabetic Vitreous Hemorrhage Unknown status NCT00300014
9 Randomized, Controlled Trial in Patients With Senile Cataract to Evaluate the Efficacy of Ultrasound-free Femtosecond Laser (FLACS) Cataract Surgery (USFREE), Compared to Traditional Phacoemulsification Surgery Using Ultrasound. Completed NCT03050008

Search NIH Clinical Center for Rubeosis Iridis

Genetic Tests for Rubeosis Iridis

Anatomical Context for Rubeosis Iridis

MalaCards organs/tissues related to Rubeosis Iridis:

40
Eye, Retina, Brain, Endothelial, Heart, Lung, Myeloid

Publications for Rubeosis Iridis

Articles related to Rubeosis Iridis:

(show top 50) (show all 400)
# Title Authors PMID Year
1
Orbital Diffuse Large B-Cell Lymphoma Initially Presenting as Neovascular Glaucoma. 61
31593042 2020
2
Rubeosis Iridis With Budding New Vessels. 61
31830222 2019
3
UPARANT is an effective antiangiogenic agent in a mouse model of rubeosis iridis. 61
31243519 2019
4
The uPAR System as a Potential Therapeutic Target in the Diseased Eye. 61
31426601 2019
5
MicroPulse™ transscleral cyclophotocoagulation in the treatment of canine glaucoma: Preliminary results (12 dogs). 61
30109763 2019
6
Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy. 61
30899298 2019
7
Current management of diabetic tractional retinal detachments. 61
30451175 2018
8
Neoadjuvant proton beam irradiation vs. adjuvant ruthenium brachytherapy in transscleral resection of uveal melanoma. 61
29907945 2018
9
Amalric triangular sign in a case of central retinal artery occlusion combined with posterior ciliary artery occlusion - Case report. 61
30094393 2018
10
Microbial keratitis-induced endophthalmitis: incidence, symptoms, therapy, visual prognosis and outcomes. 61
29724209 2018
11
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis. 61
29578513 2018
12
Topical Corticosteroid-Resolved Rubeosis Iridis with Neovascular Glaucoma Caused by Noninfectious Granulomatous Uveitis. 61
29681844 2018
13
Bilateral Hypopyon Uveitis in Chronic Myeloid Leukemia. 61
29344492 2017
14
Forceps trauma in a newborn presenting as iris heterochromia. 61
28870796 2017
15
[Retinal Vein Occlusion - Which Treatment When?] 61
28376554 2017
16
Neovascularization of the iris in retinoschisis. 61
29260089 2017
17
LONG-TERM RESULTS OF TOTAL RETINECTOMY IN CASES WITH ADVANCED PROLIFERATIVE VITREORETINOPATHY. 61
27828913 2017
18
VITREORETINAL SURGERY FOR PATIENTS WITH SEVERE EXUDATIVE AND PROLIFERATIVE MANIFESTATIONS OF RETINAL CAPILLARY HEMANGIOBLASTOMA BECAUSE OF VON HIPPEL-LINDAU DISEASE. 61
27533771 2017
19
Rubeosis iridis. 61
29881517 2017
20
INTRAOCULAR PRESSURE IN SOUTHERN ROCKHOPPER (EUDYPTES CHRYSOCOME) AND MACARONI PENGUINS (EUDYPTES CHRYSOLOPHUS): EVALUATION OF INFLUENCING FACTORS. 61
27010282 2016
21
Etiology and Features of Eyes with Rubeosis Iridis among Korean Patients: A Population-Based Single Center Study. 61
27490797 2016
22
Intravitreal aflibercept for rubeosis iridis secondary to proliferative diabetic retinopathy. 61
27215012 2015
23
[Ocular ischemic syndrome]. 61
25480566 2015
24
[Anti-VEGF therapy in the treatment of anterior segment neovascularization secondary to central retinal vein occlusion]. 61
25956562 2015
25
Efficacy and safety of intravitreal bevacizumab in eyes with neovascular glaucoma undergoing Ahmed glaucoma valve implantation: 2-year follow-up. 61
24989855 2015
26
Treatment with sodium hyaluronate eye drops in a patient who had early-onset bleb leakage after trabeculectomy with mitomycin C. 61
26664245 2015
27
Mobile lens-induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome. 61
26558230 2015
28
[Immediate improvement of ischemic oculopathy after stenting for internal carotid artery stenosis]. 61
25475037 2014
29
The effect of central retinal venous pressure in patients with central retinal vein occlusion and a high mean area of nonperfusion. 61
25037752 2014
30
Rubeosis iridis in patients with diabetes: not forgetting oculoischaemic syndrome as a differential. 61
25404252 2014
31
Advanced exudative retinopathy with neovascular glaucoma as the clinical presentation of diabetes mellitus and severe combined hyperlipidemia: a case report. 61
25816546 2014
32
Clinical manifestations of central retinal artery occlusion in eyes of proliferative diabetic retinopathy with previous vitrectomy and panretinal photocoagulation. 61
24743637 2014
33
Prevalence and causes of visual impairment in diabetic patients in Tunisia, North Africa. 61
24924439 2014
34
Histopathology of streptococcus mitis/oralis endophthalmitis after intravitreal injection with bevacizumab: a report of 7 patients. 61
24439760 2014
35
Medical management of acute ocular hypertension in a western screech owl (Megascops kennicottii). 61
24881152 2014
36
Ranibizumab as adjuvant in the treatment of rubeosis iridis and neovascular glaucoma--results from a prospective interventional case series. 61
23893090 2013
37
Retrospective analysis of the success and safety of Gold Micro Shunt Implantation in glaucoma. 61
23865804 2013
38
An interesting case of rubeosis iridis with neovascular glaucoma in a young patient. 61
24600098 2013
39
The use of intravitreal ranibizumab to treat neovascular glaucoma because of retinal amyloid angiopathy in familial amyloidosis transthyretin v30m related. 61
25390540 2013
40
Choroidal paraganglioma with metastases to the fellow eye. 61
23525329 2013
41
[Ocular ischemic syndrome--a case report]. 61
24386788 2013
42
Rubeosis iridis as a sign of underlying carotid stenosis. 61
22939702 2012
43
[Ocular ischemic syndrome with rubeosis iridis]. 61
22525726 2012
44
Ciliary-body adenoma of the non-pigmented epithelium with rubeosis iridis treated with plaque brachytherapy and bevacizumab. 61
22814808 2012
45
Effect on anterior chamber bevacizumab injection combined with seton implantation in treatment of rubeosis iridis in neovascular glaucoma. 61
21995758 2012
46
Study of clinical applications and safety for Pascal® laser photocoagulation in retinal vascular disorders. 61
20163363 2012
47
[Neovascular glaucoma--etipathogeny and diagnosis]. 61
23424756 2012
48
Anterior segment ischemia with rubeosis iridis after a circular buckling operation treated successfully with an intravitreal bevacizumab injection: a case report and review of the literature. 61
22550771 2012
49
Bilateral rubeosis iridis and rubeotic glaucoma due to peripheral occlusive vasculitis associated with multiple sclerosis. 61
21895514 2011
50
A case of cholesterosis bulbi with secondary glaucoma treated by vitrectomy and intravitreal bevacizumab. 61
21976948 2011

Variations for Rubeosis Iridis

Expression for Rubeosis Iridis

Search GEO for disease gene expression data for Rubeosis Iridis.

Pathways for Rubeosis Iridis

Pathways related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.94 PLG LAMA3
2 10.65 VEGFA PLG
3 10.11 PLG LAMA3

GO Terms for Rubeosis Iridis

Biological processes related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ovarian follicle development GO:0001541 8.96 VEGFA FANCG
2 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 8.62 VEGFA PLG

Sources for Rubeosis Iridis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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