Aliases & Classifications for Rubeosis Iridis

MalaCards integrated aliases for Rubeosis Iridis:

Name: Rubeosis Iridis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14000
ICD10 33 H21.1
ICD9CM 35 364.42
SNOMED-CT 68 51995000
UMLS 73 C0154916

Summaries for Rubeosis Iridis

MalaCards based summary : Rubeosis Iridis is related to microvascular complications of diabetes 5 and severe nonproliferative diabetic retinopathy. An important gene associated with Rubeosis Iridis is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

Wikipedia : 76 Rubeosis iridis, also called neovascularization of the iris (NVI), is a medical condition of the iris of... more...

Related Diseases for Rubeosis Iridis

Diseases related to Rubeosis Iridis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 31.2 IGF1 INS VEGFA
2 severe nonproliferative diabetic retinopathy 10.8 INS VEGFA
3 hemoglobin zurich 10.8 HBA2 HBB
4 methemoglobinemia, beta-globin type 10.8 HBA2 HBB
5 glutathione peroxidase deficiency 10.8 HBA2 HBB
6 secondary adrenal insufficiency 10.7 IGF1 INS
7 hemopericardium 10.7 PLG RPTOR
8 degenerative myopia 10.7 CRYAA VEGFA
9 large cell carcinoma with rhabdoid phenotype 10.7 ENO2 VEGFA
10 nodular nonsuppurative panniculitis 10.7 CRYAA SERPINF2 SNRPE
11 brain stem infarction 10.7 MRPS22 PLG
12 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.7 IGF1 INS
13 intestinal impaction 10.6 PLG SERPINF2
14 vitreous detachment 10.6 PLG VEGFA
15 heinz body anemias 10.6 HBA2 HBB
16 type 1 diabetes mellitus 2 10.6 IGF2 INS
17 ureter small cell carcinoma 10.5 ENO2 SYP
18 blood group, globoside system 10.5 CRYAA PLG VEGFA
19 neovascular glaucoma 10.5
20 retinitis 10.5
21 sleep apnea 10.5 IGF1 INS VEGFA
22 malignant sertoli cell tumor 10.5 ENO2 SYP
23 urinary bladder small cell neuroendocrine carcinoma 10.5 ENO2 SYP
24 auditory system cancer 10.5 ENO2 SYP
25 sinonasal undifferentiated carcinoma 10.5 ENO2 SYP
26 sensory organ benign neoplasm 10.5 ENO2 SYP
27 gallbladder small cell carcinoma 10.5 ENO2 SYP
28 alpha-2-plasmin inhibitor deficiency 10.5 PLG SERPINF2
29 duodenal somatostatinoma 10.4 ENO2 INS
30 pancreatic somatostatinoma 10.4 ENO2 SYP
31 cutaneous ganglioneuroma 10.4 ENO2 SYP
32 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
33 small cell carcinoma of the bladder 10.4 ENO2 SYP
34 glucose metabolism disease 10.4 HBA2 IGF1 INS
35 papillary tumor of the pineal region 10.4 ENO2 SYP
36 arteries, anomalies of 10.4 INS PLG VEGFA
37 orbital cancer 10.4 ENO2 SYP
38 acquired metabolic disease 10.4 HBA2 IGF1 INS
39 middle ear adenoma 10.4 ENO2 SYP
40 ovarian carcinosarcoma 10.4 ENO2 SYP
41 posterolateral myocardial infarction 10.4 PF4 PLG
42 cell type benign neoplasm 10.4 IGF1 INS SYP
43 fetal macrosomia 10.3 IGF1 IGF2 INS
44 endocrine pancreas disease 10.3 IGF1 IGF2 INS
45 pulmonary large cell neuroendocrine carcinoma 10.3 ENO2 SYP
46 pancreas disease 10.3 IGF1 IGF2 INS
47 atypical follicular adenoma 10.3 ENO2 SYP
48 hemangioblastoma 10.3 ENO2 SYP VEGFA
49 type 1 diabetes mellitus 7 10.3 HBA2 INS
50 giant hemangioma 10.3 PLG SERPINF2

Comorbidity relations with Rubeosis Iridis via Phenotypic Disease Network (PDN):


Hypertension, Essential Microvascular Complications of Diabetes 1
Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Rubeosis Iridis:



Diseases related to Rubeosis Iridis

Symptoms & Phenotypes for Rubeosis Iridis

Drugs & Therapeutics for Rubeosis Iridis

Drugs for Rubeosis Iridis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
3 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Anecortave Investigational Phase 2 10184-70-0
6 Pharmaceutical Solutions Phase 1

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Intraocular Bevacizumab (Avastin) for Rubeosis Iridis Completed NCT00557232 Phase 4 bevacizumab
2 Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion Completed NCT01710839 Phase 4 0.5mg Ranibizumab
3 Day Regimes of CONbercept on CytokinEs of PDR Patients Undergoing Vitrectomy - Trial (CONCEPT) Recruiting NCT03506750 Phase 4 IVC
4 Intravitreal Aflibercept or Ranibizumab for Rubeosis Iridis Completed NCT02641457 Phase 3 Aflibercept;Ranibizumab
5 Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients Completed NCT02396316 Phase 3 Aflibercept (Eylea, BAY 86-5321);Sham Injection
6 Central Vein Occlusion Study (CVOS) Completed NCT00000131 Phase 3
7 Bevacizumab and Long Acting Gas in Diabetic Vitrectomy Completed NCT00656435 Phase 3 Bevacizumab
8 An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases. Completed NCT01908816 Phase 3 ranibizumab
9 Multicenter Clinical Study of Anti-VEGF Treatment on High Risk Diabetic Retinopathy (DR) Not yet recruiting NCT03452657 Phase 3 Ranibizumab
10 Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Diabetic Vitreous Hemorrhage Unknown status NCT01151722 Phase 2
11 Ranibizumab For Persistent Diabetic Macular Edema After Bevacizumab Unknown status NCT01845844 Phase 1, Phase 2 Ranibizumab 0.3mg/0.05cc
12 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
13 Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imaging Completed NCT00606138 Phase 1, Phase 2 ranibizumab
14 Prevention of Retinal Non-perfusion in Central Retinal Vein Occlusion by Hydroxycarbamide Treatment. Recruiting NCT02957760 Phase 2 Hydroxycarbamid
15 Treatment of Rubeosis Iridis With Open-Label Anecortave Acetate Sterile Suspension ( 15 mg.). Terminated NCT00211471 Phase 2 anecortave acetate
16 Lucentis for New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
17 Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment Unknown status NCT00548197 Phase 1 Bevacizumab
18 A Pilot Study for the Treatment of Iris Neovascularization With Macugen Completed NCT00295828 Phase 1
19 Use of Ranibizumab to Treat Rubeosis in Diabetics Prior to Cataract Surgery Completed NCT01069341 Phase 1 Ranibizumab
20 Study of 2.0 mg Ranibizumab in Subjects With Ischemic Central Retinal Vein Occlusion (RAVE2) Terminated NCT01225146 Phase 1 ranibizumab
21 Intravitreal Bevacizumab for Neovascular Glaucoma Completed NCT00384631 Not Applicable Avastin
22 Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma Completed NCT01711879 Not Applicable Aflibercept
23 Intravitreal Bevacizumab Pretreatment for Reducing Preretinal Hemorrhage in Diabetic Vitrectomy Completed NCT00596505
24 Ultrasound Evaluation of Gastric Emptying in Diabetic Patients: a Comparison With Non-diabetic Controls Recruiting NCT03217630

Search NIH Clinical Center for Rubeosis Iridis

Genetic Tests for Rubeosis Iridis

Anatomical Context for Rubeosis Iridis

MalaCards organs/tissues related to Rubeosis Iridis:

41
Eye, Retina, Endothelial, Heart

Publications for Rubeosis Iridis

Articles related to Rubeosis Iridis:

(show top 50) (show all 91)
# Title Authors Year
1
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis. ( 29578513 )
2018
2
Topical Corticosteroid-Resolved Rubeosis Iridis with Neovascular Glaucoma Caused by Noninfectious Granulomatous Uveitis. ( 29681844 )
2018
3
Rubeosis iridis. ( 29881517 )
2017
4
Etiology and Features of Eyes with Rubeosis Iridis among Korean Patients: A Population-Based Single Center Study. ( 27490797 )
2016
5
Mobile lens-induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome. ( 26558230 )
2015
6
Intravitreal aflibercept for rubeosis iridis secondary to proliferative diabetic retinopathy. ( 27215012 )
2015
7
Rubeosis iridis in patients with diabetes: not forgetting oculoischaemic syndrome as a differential. ( 25404252 )
2014
8
Ranibizumab as adjuvant in the treatment of rubeosis iridis and neovascular glaucoma--results from a prospective interventional case series. ( 23893090 )
2013
9
An interesting case of rubeosis iridis with neovascular glaucoma in a young patient. ( 24600098 )
2013
10
Anterior segment ischemia with rubeosis iridis after a circular buckling operation treated successfully with an intravitreal bevacizumab injection: a case report and review of the literature. ( 22550771 )
2012
11
Effect on anterior chamber bevacizumab injection combined with seton implantation in treatment of rubeosis iridis in neovascular glaucoma. ( 21995758 )
2012
12
Rubeosis iridis as a sign of underlying carotid stenosis. ( 22939702 )
2012
13
Ciliary-body adenoma of the non-pigmented epithelium with rubeosis iridis treated with plaque brachytherapy and bevacizumab. ( 22814808 )
2012
14
Bilateral rubeosis iridis and rubeotic glaucoma due to peripheral occlusive vasculitis associated with multiple sclerosis. ( 21895514 )
2011
15
Rabbit rubeosis iridis induced by intravitreal latex-derived angiogenic fraction. ( 21599469 )
2011
16
Rubeosis iridis after bilateral cataract surgery and its spontaneous regression in a patient with myotonic dystrophy. ( 16765808 )
2006
17
Rapid improvement of rubeosis iridis from a single bevacizumab (Avastin) injection. ( 16508439 )
2006
18
Dilation of the minor arterial circle of the iris preceding rubeosis iridis during retinal vein occlusion. ( 15629321 )
2004
19
Treatment of rubeosis iridis with photodynamic therapy with verteporfin--A new therapeutic and prophylactic option for patients with the risk of neovascular glaucoma? ( 12566865 )
2003
20
Fluorescein angiography of extreme peripheral retina and rubeosis iridis in proliferative diabetic retinopathy. ( 10458295 )
1999
21
Iridopathy in eyes with proliferative diabetic retinopathy: detection of early stage of rubeosis iridis. ( 9438578 )
1998
22
Neovascular complications associated with rubeosis iridis and peripheral retinal detachment after retinal detachment surgery. ( 9744371 )
1998
23
Rubeosis iridis after vitrectomy for diabetic retinopathy. ( 9801886 )
1998
24
Peripheral transscleral retinal diode laser for rubeosis iridis. ( 9730191 )
1998
25
Rubeosis iridis in retinoblastoma. Histologic findings and the possible role of vascular endothelial growth factor in its induction. ( 9261311 )
1997
26
Peripheral transscleral retinal diode laser for rubeosis iridis. ( 9355190 )
1997
27
Regression of rubeosis iridis after trabeculectomy combined with mitomycin-C. ( 8858638 )
1996
28
Comparison between efficacy of full- and mild-scatter (panretinal) photocoagulation on the course of diabetic rubeosis iridis. ( 7506403 )
1993
29
Rubeosis iridis and neovascular glaucoma: II. Our own experiences with the treatment by cryocoagulation. ( 1364952 )
1992
30
Rubeosis iridis and neovascular glaucoma: I. Etiopathogenesis and treatment--the present state of the problem. ( 1364951 )
1992
31
Extracapsular cataract extraction in diabetics with rubeosis iridis. ( 1446764 )
1992
32
Acute onset of rubeosis iridis after diabetic vitrectomy can indicate peripheral traction retinal detachment. ( 1283355 )
1992
33
Ultrastructure and blood-iris barrier in experimental rubeosis iridis in rabbit. ( 1709217 )
1990
34
Peripheral retinal neovascularization and rubeosis iridis after a bilateral circular buckling operation. ( 2454062 )
1988
35
Optic disk neovascularization and rubeosis iridis after surgical resection of the optic nerve. ( 2456697 )
1988
36
Early electroretinography in unilateral central retinal vein occlusion as a predictor of rubeosis iridis. ( 2449883 )
1988
37
Radiation retinopathy as an experimental model for ischemic proliferative retinopathy and rubeosis iridis. ( 2438938 )
1987
38
Fundus-iris fluorescein angiography: evaluation of its use in the diagnosis of rubeosis iridis. ( 2420247 )
1986
39
Pars plana vitrectomy and intravitreal silicone oil injection in eyes with rubeosis iridis. ( 3955437 )
1986
40
Hypotony and experimental rubeosis iridis in primate eyes. A clinicopathologic study. ( 2428697 )
1986
41
Rubeosis iridis: preoperative iris fluorescein angiography and periocular steroids. ( 6201792 )
1984
42
The lens capsule and rubeosis iridis: an angiographic study. ( 6203631 )
1984
43
Scanning electron microscopy of rubeosis iridis. ( 6188249 )
1982
44
Regression of diabetic rubeosis iridis following successful surgical reattachment of the retina by vitrectomy. ( 6101125 )
1982
45
A case of diabetic rubeosis iridis without significant observable retinopathy. ( 6184390 )
1982
46
Goniophotocoagulation in the management of rubeosis iridis. ( 6176826 )
1981
47
Rubeosis iridis in "pseudogliomas". ( 6160630 )
1980
48
Effects of argon laser photocoagulation on rubeosis iridis and angle neovascularization. ( 6157141 )
1980
49
Prognosis for rubeosis iridis following central retinal vein occlusion. ( 508688 )
1979
50
Development and classification of rubeosis iridis in diabetic eye disease. ( 435423 )
1979

Variations for Rubeosis Iridis

Expression for Rubeosis Iridis

Search GEO for disease gene expression data for Rubeosis Iridis.

Pathways for Rubeosis Iridis

Pathways related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 HBB IGF1 IGF2 PF4 PLG SERPINF2
2
Show member pathways
12.65 IGF1 INS PLG RPTOR VEGFA
3 11.51 IGF1 SYP VEGFA
4 11.36 IGF1 IGF2 VEGFA
5 11.28 IGF1 IGF2 PLG
6 11.26 ENO2 IGF1 INS VEGFA
7 11.16 IGF1 IGF2 INS
8 11.01 IGF1 INS VEGFA
9 10.57 PLG SERPINF2
10 10.12 IGF1 IGF2 PLG

GO Terms for Rubeosis Iridis

Cellular components related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 APEH HBA2 HBB IGF1 IGF2 INS
2 extracellular space GO:0005615 9.65 ENO2 HBA2 HBB IGF1 IGF2 INS
3 blood microparticle GO:0072562 9.62 HBA2 HBB PLG SERPINF2
4 endocytic vesicle lumen GO:0071682 9.43 HBA2 HBB
5 hemoglobin complex GO:0005833 9.4 HBA2 HBB
6 haptoglobin-hemoglobin complex GO:0031838 9.26 HBA2 HBB
7 platelet alpha granule lumen GO:0031093 9.1 IGF1 IGF2 PF4 PLG SERPINF2 VEGFA
8 extracellular exosome GO:0070062 10.07 APEH CRYAA ENO2 HBA2 HBB IGF2

Biological processes related to Rubeosis Iridis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 CRYAA IGF1 IGF2 INS VEGFA
2 regulation of signaling receptor activity GO:0010469 9.83 IGF1 IGF2 INS PF4 VEGFA
3 cellular protein metabolic process GO:0044267 9.78 IGF1 IGF2 INS PLG
4 glucose homeostasis GO:0042593 9.72 IGF1 IGF2 INS
5 response to glucose GO:0009749 9.7 IGF1 IGF2 INS
6 response to insulin GO:0032868 9.67 IGF1 IGF2 INS
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.63 IGF1 IGF2 INS
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.62 IGF1 IGF2 INS VEGFA
9 response to nutrient levels GO:0031667 9.58 IGF1 IGF2 INS
10 oxygen transport GO:0015671 9.56 HBA2 HBB
11 positive regulation of mitotic nuclear division GO:0045840 9.54 IGF1 IGF2 INS
12 negative regulation of fibrinolysis GO:0051918 9.51 PLG SERPINF2
13 positive regulation of insulin receptor signaling pathway GO:0046628 9.43 IGF1 IGF2 INS
14 response to organic substance GO:0010033 9.35 IGF1 IGF2 INS SERPINF2 SLC6A1
15 positive regulation of glycogen biosynthetic process GO:0045725 9.33 IGF1 IGF2 INS
16 platelet degranulation GO:0002576 9.1 IGF1 IGF2 PF4 PLG SERPINF2 VEGFA

Molecular functions related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.54 IGF1 IGF2 INS
2 insulin receptor binding GO:0005158 9.33 IGF1 IGF2 INS
3 oxygen carrier activity GO:0005344 9.32 HBA2 HBB
4 haptoglobin binding GO:0031720 9.26 HBA2 HBB
5 insulin-like growth factor receptor binding GO:0005159 9.13 IGF1 IGF2 INS
6 receptor activator activity GO:0030546 8.8 IGF1 IGF2 INS

Sources for Rubeosis Iridis

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