MCID: RBS002
MIFTS: 36

Rubeosis Iridis

Categories: Eye diseases

Aliases & Classifications for Rubeosis Iridis

MalaCards integrated aliases for Rubeosis Iridis:

Name: Rubeosis Iridis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14000
ICD10 33 H21.1
ICD9CM 35 364.42
SNOMED-CT 68 51995000
UMLS 73 C0154916

Summaries for Rubeosis Iridis

MalaCards based summary : Rubeosis Iridis is related to microvascular complications of diabetes 5 and microvascular complications of diabetes 1. An important gene associated with Rubeosis Iridis is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are HIF-1 signaling pathway and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and heart.

Wikipedia : 76 Rubeosis iridis, also called neovascularization of the iris (NVI), is a medical condition of the iris of... more...

Related Diseases for Rubeosis Iridis

Diseases related to Rubeosis Iridis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 30.9 IGF1 INS VEGFA
2 microvascular complications of diabetes 1 30.8 IGF1 INS VEGFA
3 neovascular glaucoma 10.7
4 microvascular complications of diabetes 2 10.4
5 retinal vein occlusion 10.4
6 retinal detachment 10.3
7 retinoblastoma 10.3
8 cataract 10.3
9 central retinal vein occlusion 10.3
10 acute endophthalmitis 10.3 NDUFS4 VEGFA
11 severe nonproliferative diabetic retinopathy 10.2 INS VEGFA
12 degenerative myopia 10.2 CRYAA VEGFA
13 hemoglobin zurich 10.2 HBA2 HBB
14 methemoglobinemia, beta-globin type 10.2 HBA2 HBB
15 glutathione peroxidase deficiency 10.2 HBA2 HBB
16 nodular nonsuppurative panniculitis 10.2 CRYAA SERPINF2 SNRPE
17 secondary adrenal insufficiency 10.2 IGF1 INS
18 multiple sclerosis 10.2
19 sturge-weber syndrome 10.2
20 heart disease 10.2
21 carotid stenosis 10.2
22 uveitis 10.2
23 primary angle-closure glaucoma 10.2
24 melanoma 10.2
25 ischemia 10.2
26 adenoma 10.2
27 vasculitis 10.2
28 myotonic dystrophy 10.2
29 myotonia atrophica 10.2
30 weber syndrome 10.2
31 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.2 IGF1 INS
32 heinz body anemias 10.2 HBA2 HBB
33 type 1 diabetes mellitus 7 10.2 HBA2 INS
34 background diabetic retinopathy 10.2 HBA2 INS VEGFA
35 retinal vascular disease 10.1 HBA2 INS VEGFA
36 type 1 diabetes mellitus 11 10.1 HBA2 INS
37 pancreatic serous cystadenoma 10.1 SYP VEGFA
38 purulent endophthalmitis 10.1 NDUFS4 SYP VEGFA
39 type 1 diabetes mellitus 2 10.1 IGF2 INS
40 autosomal genetic disease 10.1 HBB INS VEGFA
41 immature cataract 10.1 CRYAA HBA2
42 gonadal disease 10.1 IGF1 INS VEGFA
43 pancreatic endocrine carcinoma 10.1 INS SYP
44 carcinoid syndrome 10.1 IGF1 SYP VEGFA
45 platelet aggregation, spontaneous 10.1 PF4 SERPINF2
46 pseudopapilledema 10.1 IGF1 IGF2
47 glucose metabolism disease 10.1 HBA2 IGF1 INS
48 acquired metabolic disease 10.1 HBA2 IGF1 INS
49 cerebral neuroblastoma 10.1 IGF2 SYP
50 cold urticaria 10.0 PF4 SERPINF2

Comorbidity relations with Rubeosis Iridis via Phenotypic Disease Network (PDN):


Hypertension, Essential Microvascular Complications of Diabetes 1
Microvascular Complications of Diabetes 7

Graphical network of the top 20 diseases related to Rubeosis Iridis:



Diseases related to Rubeosis Iridis

Symptoms & Phenotypes for Rubeosis Iridis

Drugs & Therapeutics for Rubeosis Iridis

Drugs for Rubeosis Iridis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 216974-75-3
2
Ranibizumab Approved Phase 4,Phase 3,Phase 1,Phase 2 347396-82-1 459903
3 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
4 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2
6 Anecortave Investigational Phase 2 10184-70-0
7 Pharmaceutical Solutions Phase 1

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Intraocular Bevacizumab (Avastin) for Rubeosis Iridis Completed NCT00557232 Phase 4 bevacizumab
2 Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion Completed NCT01710839 Phase 4 0.5mg Ranibizumab
3 Day Regimes of CONbercept on CytokinEs of PDR Patients Undergoing Vitrectomy - Trial (CONCEPT) Recruiting NCT03506750 Phase 4 IVC
4 Intravitreal Aflibercept or Ranibizumab for Rubeosis Iridis Completed NCT02641457 Phase 3 Aflibercept;Ranibizumab
5 Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients Completed NCT02396316 Phase 3 Aflibercept (Eylea, BAY 86-5321);Sham Injection
6 Central Vein Occlusion Study (CVOS) Completed NCT00000131 Phase 3
7 Bevacizumab and Long Acting Gas in Diabetic Vitrectomy Completed NCT00656435 Phase 3 Bevacizumab
8 An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases. Completed NCT01908816 Phase 3 ranibizumab
9 Study to Learn How the Drug Aflibercept Works in in Japanese Patients With Increased Eye Pressure That is Caused by New Blood Vessels Growing in the Eye (Neovascular Glaucoma or NVG). Safety of the Drug and Patients' Tolerability of the Drug Injection is Also Studied Recruiting NCT03639675 Phase 3 Aflibercept (EYLEA, BAY86-5321);Topical IOP-lowering drugs
10 Multicenter Clinical Study of Anti-VEGF Treatment on High Risk Diabetic Retinopathy (DR) Not yet recruiting NCT03452657 Phase 3 Ranibizumab
11 Adjuvant Intravitreal Bevacizumab in Pars Plana Vitrectomy for Diabetic Vitreous Hemorrhage Unknown status NCT01151722 Phase 2
12 Prevention of Retinal Non-perfusion in Central Retinal Vein Occlusion by Hydroxycarbamide Treatment. Unknown status NCT02957760 Phase 2 Hydroxycarbamid
13 Ranibizumab For Persistent Diabetic Macular Edema After Bevacizumab Unknown status NCT01845844 Phase 1, Phase 2 Ranibizumab 0.3mg/0.05cc
14 Treatment of Exudative and Vasogenic Chorioretinal Diseases Including Variants of AMD and Other CNV Related Maculopathy Completed NCT00470977 Phase 1, Phase 2 ranibizumab injection (0.5 mg)
15 Ranibizumab for Treatment of Persistent Diabetic Neovascularization Assessed by Wide-Field Imaging Completed NCT00606138 Phase 1, Phase 2 ranibizumab
16 Treatment of Rubeosis Iridis With Open-Label Anecortave Acetate Sterile Suspension ( 15 mg.). Terminated NCT00211471 Phase 2 anecortave acetate
17 Lucentis for New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
18 A Pilot Study for the Treatment of Iris Neovascularization With Macugen Completed NCT00295828 Phase 1
19 Use of Ranibizumab to Treat Rubeosis in Diabetics Prior to Cataract Surgery Completed NCT01069341 Phase 1 Ranibizumab
20 Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment Completed NCT00548197 Phase 1 Bevacizumab
21 Study of 2.0 mg Ranibizumab in Subjects With Ischemic Central Retinal Vein Occlusion (RAVE2) Terminated NCT01225146 Phase 1 ranibizumab
22 Intravitreal Bevacizumab for Neovascular Glaucoma Completed NCT00384631 Not Applicable Avastin
23 Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma Completed NCT01711879 Not Applicable Aflibercept
24 Intravitreal Bevacizumab Pretreatment for Reducing Preretinal Hemorrhage in Diabetic Vitrectomy Completed NCT00596505
25 Ultrasound Evaluation of Gastric Emptying in Diabetic Patients: a Comparison With Non-diabetic Controls Recruiting NCT03217630

Search NIH Clinical Center for Rubeosis Iridis

Genetic Tests for Rubeosis Iridis

Anatomical Context for Rubeosis Iridis

MalaCards organs/tissues related to Rubeosis Iridis:

41
Eye, Retina, Heart, Endothelial, Ovary, Pancreas, Pineal

Publications for Rubeosis Iridis

Articles related to Rubeosis Iridis:

(show top 50) (show all 93)
# Title Authors Year
1
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis. ( 29578513 )
2018
2
Topical Corticosteroid-Resolved Rubeosis Iridis with Neovascular Glaucoma Caused by Noninfectious Granulomatous Uveitis. ( 29681844 )
2018
3
Rubeosis iridis. ( 29881517 )
2017
4
Etiology and Features of Eyes with Rubeosis Iridis among Korean Patients: A Population-Based Single Center Study. ( 27490797 )
2016
5
Mobile lens-induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome. ( 26558230 )
2015
6
Intravitreal aflibercept for rubeosis iridis secondary to proliferative diabetic retinopathy. ( 27215012 )
2015
7
Rubeosis iridis in patients with diabetes: not forgetting oculoischaemic syndrome as a differential. ( 25404252 )
2014
8
Ranibizumab as adjuvant in the treatment of rubeosis iridis and neovascular glaucoma--results from a prospective interventional case series. ( 23893090 )
2013
9
An interesting case of rubeosis iridis with neovascular glaucoma in a young patient. ( 24600098 )
2013
10
Anterior segment ischemia with rubeosis iridis after a circular buckling operation treated successfully with an intravitreal bevacizumab injection: a case report and review of the literature. ( 22550771 )
2012
11
Effect on anterior chamber bevacizumab injection combined with seton implantation in treatment of rubeosis iridis in neovascular glaucoma. ( 21995758 )
2012
12
Rubeosis iridis as a sign of underlying carotid stenosis. ( 22939702 )
2012
13
Ciliary-body adenoma of the non-pigmented epithelium with rubeosis iridis treated with plaque brachytherapy and bevacizumab. ( 22814808 )
2012
14
Bilateral rubeosis iridis and rubeotic glaucoma due to peripheral occlusive vasculitis associated with multiple sclerosis. ( 21895514 )
2011
15
Rabbit rubeosis iridis induced by intravitreal latex-derived angiogenic fraction. ( 21599469 )
2011
16
Rubeosis iridis after bilateral cataract surgery and its spontaneous regression in a patient with myotonic dystrophy. ( 16765808 )
2006
17
Rapid improvement of rubeosis iridis from a single bevacizumab (Avastin) injection. ( 16508439 )
2006
18
Dilation of the minor arterial circle of the iris preceding rubeosis iridis during retinal vein occlusion. ( 15629321 )
2004
19
Treatment of rubeosis iridis with photodynamic therapy with verteporfin--A new therapeutic and prophylactic option for patients with the risk of neovascular glaucoma? ( 12566865 )
2003
20
Fluorescein angiography of extreme peripheral retina and rubeosis iridis in proliferative diabetic retinopathy. ( 10458295 )
1999
21
Iridopathy in eyes with proliferative diabetic retinopathy: detection of early stage of rubeosis iridis. ( 9438578 )
1998
22
Neovascular complications associated with rubeosis iridis and peripheral retinal detachment after retinal detachment surgery. ( 9744371 )
1998
23
Rubeosis iridis after vitrectomy for diabetic retinopathy. ( 9801886 )
1998
24
Peripheral transscleral retinal diode laser for rubeosis iridis. ( 9730191 )
1998
25
Rubeosis iridis in retinoblastoma. Histologic findings and the possible role of vascular endothelial growth factor in its induction. ( 9261311 )
1997
26
Peripheral transscleral retinal diode laser for rubeosis iridis. ( 9355190 )
1997
27
Regression of rubeosis iridis after trabeculectomy combined with mitomycin-C. ( 8858638 )
1996
28
Comparison between efficacy of full- and mild-scatter (panretinal) photocoagulation on the course of diabetic rubeosis iridis. ( 7506403 )
1993
29
Rubeosis iridis and neovascular glaucoma: II. Our own experiences with the treatment by cryocoagulation. ( 1364952 )
1992
30
Rubeosis iridis and neovascular glaucoma: I. Etiopathogenesis and treatment--the present state of the problem. ( 1364951 )
1992
31
Extracapsular cataract extraction in diabetics with rubeosis iridis. ( 1446764 )
1992
32
Acute onset of rubeosis iridis after diabetic vitrectomy can indicate peripheral traction retinal detachment. ( 1283355 )
1992
33
Ultrastructure and blood-iris barrier in experimental rubeosis iridis in rabbit. ( 1709217 )
1990
34
Peripheral retinal neovascularization and rubeosis iridis after a bilateral circular buckling operation. ( 2454062 )
1988
35
Optic disk neovascularization and rubeosis iridis after surgical resection of the optic nerve. ( 2456697 )
1988
36
Early electroretinography in unilateral central retinal vein occlusion as a predictor of rubeosis iridis. ( 2449883 )
1988
37
Radiation retinopathy as an experimental model for ischemic proliferative retinopathy and rubeosis iridis. ( 2438938 )
1987
38
Fundus-iris fluorescein angiography: evaluation of its use in the diagnosis of rubeosis iridis. ( 2420247 )
1986
39
Pars plana vitrectomy and intravitreal silicone oil injection in eyes with rubeosis iridis. ( 3955437 )
1986
40
Hypotony and experimental rubeosis iridis in primate eyes. A clinicopathologic study. ( 2428697 )
1986
41
Rubeosis iridis: preoperative iris fluorescein angiography and periocular steroids. ( 6201792 )
1984
42
The lens capsule and rubeosis iridis: an angiographic study. ( 6203631 )
1984
43
The myofibroblastic component of rubeosis iridis. ( 6193475 )
1983
44
Scanning electron microscopy of rubeosis iridis. ( 6188249 )
1982
45
Regression of diabetic rubeosis iridis following successful surgical reattachment of the retina by vitrectomy. ( 6101125 )
1982
46
A case of diabetic rubeosis iridis without significant observable retinopathy. ( 6184390 )
1982
47
Goniophotocoagulation in the management of rubeosis iridis. ( 6176826 )
1981
48
Rubeosis iridis in "pseudogliomas". ( 6160630 )
1980
49
Effects of argon laser photocoagulation on rubeosis iridis and angle neovascularization. ( 6157141 )
1980
50
Prognosis for rubeosis iridis following central retinal vein occlusion. ( 508688 )
1979

Variations for Rubeosis Iridis

Expression for Rubeosis Iridis

Search GEO for disease gene expression data for Rubeosis Iridis.

Pathways for Rubeosis Iridis

Pathways related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.5 IGF1 INS VEGFA
2 11.33 IGF1 SYP VEGFA
3 11.14 IGF1 IGF2 VEGFA
4 10.86 IGF1 IGF2 INS
5 10.48 IGF1 INS VEGFA

GO Terms for Rubeosis Iridis

Cellular components related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 HBA2 HBB IGF1 IGF2 INS PF4
2 extracellular region GO:0005576 9.61 APEH HBA2 HBB IGF1 IGF2 INS
3 endocytic vesicle lumen GO:0071682 9.37 HBA2 HBB
4 hemoglobin complex GO:0005833 9.32 HBA2 HBB
5 haptoglobin-hemoglobin complex GO:0031838 9.16 HBA2 HBB
6 platelet alpha granule lumen GO:0031093 9.02 IGF1 IGF2 PF4 SERPINF2 VEGFA

Biological processes related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.65 IGF1 IGF2 INS PF4 VEGFA
2 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.5 IGF1 IGF2 VEGFA
3 positive regulation of glycolytic process GO:0045821 9.43 IGF1 INS
4 positive regulation of insulin receptor signaling pathway GO:0046628 9.4 IGF2 INS
5 oxygen transport GO:0015671 9.37 HBA2 HBB
6 positive regulation of mitotic nuclear division GO:0045840 9.33 IGF1 IGF2 INS
7 positive regulation of glycogen biosynthetic process GO:0045725 9.13 IGF1 IGF2 INS
8 platelet degranulation GO:0002576 9.02 IGF1 IGF2 PF4 SERPINF2 VEGFA

Molecular functions related to Rubeosis Iridis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.58 IGF1 IGF2 INS
2 protease binding GO:0002020 9.54 INS NDUFS7 SERPINF2
3 oxygen carrier activity GO:0005344 9.32 HBA2 HBB
4 organic acid binding GO:0043177 9.26 HBA2 HBB
5 haptoglobin binding GO:0031720 9.16 HBA2 HBB
6 insulin receptor binding GO:0005158 9.13 IGF1 IGF2 INS
7 insulin-like growth factor receptor binding GO:0005159 8.8 IGF1 IGF2 INS

Sources for Rubeosis Iridis

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